2AOAA

Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the grb2 sh2 domain
Total Genus 19
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
19
sequence length
93
structure length
93
Chain Sequence
HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Growth factor receptor-bound protein 2
total genus 19
structure length 93
sequence length 93
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-08-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00017 SH2 SH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 2aoaA00
1FHSA 3QWXX 4A4BA 1O4QA 1R1SA 2RVFA 4JEGA 1FBVA 2PNBA 2FO0A 4L1BB 1NZVA 4U1PA 4H1OA 4XZ1A 5GJHA 3VRQA 1BF5A 1ZFPE 3IMDA 3IN8A 1JYUA 1A81A 1JWOA 1QCFA 4XZ0A 4DGPA 4GPLB 4LUEA 2AOBA 1A07A 1D4TA 5AULA 5HKZA 4ROJA 5D0JA 1O48A 3ZNIA 3VRZA 2AOAA 1BG1A 1WQUA 1X6CA 2RSYA 4D8KA 4WWQA 2CIAA 4EY0A 1QG1E 2BBUA 1BKLA 3IN7A 1SPSA 3VS4A 2CI8A 1AOTF 2EOBA 1O4EA 1AYBA 2L3TA 1BHHA 4A4CA 5DC4A 1CWDL 5CDWA 3BUNB 2C0OA 1JYQA 2DX0A 1BHFA 3PLFB 1TZEE 2DLZA 1O4LA 3HIZB 1Z3KA 3VROA 3CBLA 1O4KA 2PLDA 2IUIA 4U17A 1BLKA 1CSYA 3VRYA 5BO4A 2MQIA 1SHAA 2RORA 3OP0A 2RMXA 2XP1A 3S8NA 5DF6A 1XA6A 1O4CA 3VS3A 1AYAA 1JU5A 2H46E 5DC9A 2K7AB 1BMBA 1F2FA 1MILA 4F5AA 1A08A 5IBSA 1O4FA 4OHDA 3BUXB 4F59A 1O45A 2HMHA 2EO6A 2MRJA 1LKLA 1CSZA 3VRRA 1D1ZA 1A1CA 2MK2A 1KC2A 1NZLA 2H5KA 3VS0A 1O4OA 1RQQC 3HHMB 1A1BA 1R1QA 2EYVA 4TZIA 5DC0B 1AOUF 1O4DA 4LUDA 2YSXA 2L6KA 3OB2B 3TKZA 2ABLA 2JYQA 3QWYA 2CBLA 4K45A 1B47A 3UF4A 1O42A 1GRIA 3K2MA 3T04A 4OHIA 4NWGA 3S9KA 2YU7A 1O4HA 1X0NA 5EHRA 1OO4A 1LKKA 5J3XA 2OZOA 1CWEA 5GJIA 1O4NA 1SKJA 4FBNA 1RPYA 5EELA 2KK6A 3GXXA 1FYRA 4K44A 3PSJA 1O47A 1O43A 3VS5A 3VS2A 2DM0A 1M27A 4JGHA 3TL0A 2QMSA 3VS1A 1YVLA 1KA7A 2AUGA 1Y1UA 4JE4A 1SPRA 2C0TA 1BFJA 1AYDA 2MC1A 3KFJA 5HKYA 1YVHA 1IS0A 4E93A 3EACA 5EHPA 1GHUA 1BHHB 4OHEA 5EG3B 1OO3A 1K9AA 3EAZA 2K79B 1I3ZA 1BLJA 1HCTB 1KSWA 2B3OA 1FMKA 4GL9E 2DVJA 2Y3AB 5KAZA 4NWFA 3IMJA 3VS6A 1KA6A 4GWFA 1O46A 1R1PA 2CI9A 1FU6A 1Y57A 1AD5A 2EU0A 4EIHA 5I6VA 3MXCA 5EEQA 1O4BA 1TCEA 1RJAA 1BM2A 1AYCA 3US4A 2HDVA 1LUIA 3NHNA 2EKXA 1AB2A 3BUOB 1O4AA 2MRKA 1IJRA 2GE9A 2SRCA 3VGOA 3OV1A 1P13A 1BKMA 2LNWA 2GSBA 3S8LA 4OHHA 3GXWA 3WA4A 1JYRA 3CD3A 1BFIA 2VIFA 2Y1NA 3BKBA 3N84A 2EL8A 2ETZA 2EYYA 3N7YA 5AXIA 4OHLA 1OPKA 2IUGA 3MAZA 1X27A 1PICA 2L4KA 4P9ZA 3S8OA 5HKWA 1A1EA 2SHPA 3PJPA 2CRHA 1LUKA 3M7FA 1O4RA 1MW4A 1OPLA 2IUHA 1LCJA 3GQIB 3HCKA 5IBMA 4FL2A 3UYOA 1H9OA 4E68A 2HCKA 3N8MA 1O4JA 2ECDA 1SHDA 1O41A 3CWGA 2IZVA 1F1WA 2LNXA 2H8HA 2CS0A 1UUSA 3OB1B 1O49A 1QADA 1D4WA 1SHBA 1G83A 2LQNA 3BUMB 2PTKA 3MXYA 4F5BA 3CXLA 4DGXA 4K2RA 3OVEA 4K11A 2LCTA 1CJ1A 2C0IA 2HDXA 3PFVA 1O4PA 4M4ZA 1A09A 1A1AA 3VRPA 4QSYA 4X6SA 2OQ1A 4FL3A 2Y1MA 2HUWA 1FU5A 1NRVA 2KNOA 3PSKA 2DLYA 2EYZA 2FCIA 2PNAA 2DCRA 1M61A 2CR4A 1HCSB 1O4MA 1LUMA 1O4GA 2C9WA 3PS5A 4P9VA 1FBZA 3PQZA 1O44A 4H34A 3C7IA 1LUNA 3VS7A 1LCKA 1UURA 1O4IA 3BUWB 2EO3A 3VRNA 2LQWA 2PLEA
chains in the Genus database with same CATH superfamily
1FHSA 3QWXX 4A4BA 1O4QA 1R1SA 2RVFA 4JEGA 1FBVA 2LRAA 2PNBA 2FO0A 4L1BB 1NZVA 4U1PA 4H1OA 3K2TA 4XZ1A 5GJHA 3VRQA 1BF5A 1ZFPE 3IMDA 3IN8A 1JYUA 1A81A 1JWOA 1QCFA 4XZ0A 4DGPA 4GPLB 4LUEA 2AOBA 1A07A 1D4TA 5AULA 5HKZA 4ROJA 2KGYA 5D0JA 1O48A 3ZNIA 3VRZA 2AOAA 1BG1A 1WQUA 1X6CA 2RSYA 4D8KA 4WWQA 2CIAA 4EY0A 1QG1E 2BBUA 1BKLA 3IN7A 1SPSA 3VS4A 2CI8A 1AOTF 2EOBA 1O4EA 1AYBA 2L3TA 1BHHA 4A4CA 5DC4A 1CWDL 5CDWA 3BUNB 2C0OA 1JYQA 2DX0A 1BHFA 3PLFB 1TZEE 2DLZA 1O4LA 3HIZB 1Z3KA 3VROA 3CBLA 1O4KA 2PLDA 2IUIA 4U17A 1BLKA 1CSYA 3VRYA 5BO4A 2MQIA 1SHAA 2RORA 3OP0A 2RMXA 2XP1A 3S8NA 5DF6A 1XA6A 1O4CA 3VS3A 1AYAA 1JU5A 2H46E 5DC9A 2K7AB 1BMBA 1F2FA 1MILA 4F5AA 1A08A 5IBSA 1O4FA 4OHDA 3BUXB 4F59A 1O45A 2HMHA 2EO6A 2MRJA 1LKLA 1CSZA 3VRRA 1D1ZA 1A1CA 2MK2A 1KC2A 1NZLA 2H5KA 3VS0A 1O4OA 1RQQC 3HHMB 1A1BA 1R1QA 2EYVA 4TZIA 5DC0B 1AOUF 1O4DA 4LUDA 2YSXA 2L6KA 3OB2B 3TKZA 2ABLA 2JYQA 3QWYA 2CBLA 4K45A 1B47A 3UF4A 1O42A 1GRIA 3K2MA 3T04A 4OHIA 4NWGA 3S9KA 2YU7A 1O4HA 1X0NA 5EHRA 1OO4A 1LKKA 5J3XA 2OZOA 1CWEA 5GJIA 1O4NA 1SKJA 4FBNA 1RPYA 5EELA 2KK6A 3GXXA 1FYRA 4K44A 3PSJA 1O47A 1O43A 3VS5A 3VS2A 2DM0A 1M27A 4JGHA 3TL0A 2QMSA 3VS1A 1YVLA 1KA7A 2AUGA 1Y1UA 4JE4A 1SPRA 2C0TA 1BFJA 1AYDA 2MC1A 3KFJA 5HKYA 1YVHA 1IS0A 4E93A 3EACA 5EHPA 1GHUA 1BHHB 4OHEA 5EG3B 1OO3A 1K9AA 3EAZA 2K79B 1I3ZA 1BLJA 1HCTB 1KSWA 2B3OA 1FMKA 4GL9E 2DVJA 2Y3AB 5KAZA 4NWFA 3IMJA 3VS6A 1KA6A 4GWFA 1O46A 1R1PA 2CI9A 1FU6A 1Y57A 1AD5A 2EU0A 4EIHA 5I6VA 3MXCA 5EEQA 1O4BA 1TCEA 1RJAA 1BM2A 1AYCA 3US4A 2HDVA 1LUIA 3NHNA 2EKXA 1AB2A 3BUOB 1O4AA 2MRKA 1IJRA 2GE9A 2SRCA 3VGOA 3OV1A 1P13A 1BKMA 2LNWA 2GSBA 3S8LA 4OHHA 3GXWA 3WA4A 1JYRA 3CD3A 1BFIA 2VIFA 2Y1NA 3BKBA 3N84A 2EL8A 2ETZA 2EYYA 3N7YA 5AXIA 4OHLA 1OPKA 2IUGA 3MAZA 1X27A 1PICA 2L4KA 4P9ZA 3S8OA 5HKWA 1A1EA 2SHPA 3PJPA 2CRHA 1LUKA 3M7FA 1O4RA 1MW4A 1OPLA 2IUHA 1LCJA 3GQIB 3HCKA 5IBMA 4FL2A 3UYOA 1H9OA 4E68A 2HCKA 3N8MA 1O4JA 2ECDA 1SHDA 1O41A 3CWGA 2IZVA 1F1WA 2LNXA 2H8HA 2CS0A 1UUSA 3OB1B 1O49A 1QADA 1D4WA 1SHBA 1G83A 2LQNA 3BUMB 2PTKA 3MXYA 4F5BA 3CXLA 4DGXA 4K2RA 3OVEA 4K11A 2LCTA 1CJ1A 2C0IA 2HDXA 3PFVA 1O4PA 4M4ZA 1A09A 1A1AA 3VRPA 4QSYA 4X6SA 2OQ1A 4FL3A 2Y1MA 2HUWA 1FU5A 1NRVA 2KNOA 3PSKA 2DLYA 2EYZA 2FCIA 2PNAA 2DCRA 1M61A 2CR4A 1HCSB 1O4MA 1LUMA 1O4GA 2C9WA 3PS5A 4P9VA 1FBZA 3LYVA 3PQZA 1O44A 4H34A 3C7IA 1LUNA 3VS7A 1LCKA 1UURA 1O4IA 3BUWB 2EO3A 3VRNA 2LQWA 2PLEA
chains in the Genus database with same CATH topology
1FHSA 3QWXX 4A4BA 1O4QA 1R1SA 2RVFA 4JEGA 1FBVA 2PNBA 2FO0A 4L1BB 1NZVA 4U1PA 4H1OA 4XZ1A 5GJHA 3VRQA 1BF5A 1ZFPE 3IMDA 3IN8A 1JYUA 1A81A 1JWOA 1QCFA 4XZ0A 4DGPA 4GPLB 4LUEA 2AOBA 1A07A 1D4TA 5AULA 5HKZA 4ROJA 5D0JA 1O48A 3ZNIA 3VRZA 2AOAA 1BG1A 1WQUA 1X6CA 2RSYA 4D8KA 4WWQA 2CIAA 4EY0A 1QG1E 2BBUA 1BKLA 3IN7A 1SPSA 3VS4A 2CI8A 1AOTF 2EOBA 1O4EA 1AYBA 2L3TA 1BHHA 4A4CA 5DC4A 1CWDL 5CDWA 3BUNB 2C0OA 1JYQA 2DX0A 1BHFA 3PLFB 1TZEE 2DLZA 1O4LA 3HIZB 1Z3KA 3VROA 3CBLA 1O4KA 2PLDA 2IUIA 4U17A 1BLKA 1CSYA 3VRYA 5BO4A 2MQIA 1SHAA 2RORA 3OP0A 2RMXA 2XP1A 3S8NA 5DF6A 1XA6A 1O4CA 3VS3A 1AYAA 1JU5A 2H46E 5DC9A 2K7AB 1BMBA 1F2FA 1MILA 4F5AA 1A08A 5IBSA 1O4FA 4OHDA 3BUXB 4F59A 1O45A 2HMHA 2EO6A 2MRJA 1LKLA 1CSZA 3VRRA 1D1ZA 1A1CA 2MK2A 1KC2A 1NZLA 2H5KA 3VS0A 1O4OA 1RQQC 3HHMB 1A1BA 1R1QA 2EYVA 4TZIA 5DC0B 1AOUF 1O4DA 4LUDA 2YSXA 2L6KA 3OB2B 3TKZA 2ABLA 2JYQA 3QWYA 2CBLA 4K45A 1B47A 3UF4A 1O42A 1GRIA 3K2MA 3T04A 4OHIA 4NWGA 3S9KA 2YU7A 1O4HA 1X0NA 5EHRA 1OO4A 1LKKA 5J3XA 2OZOA 1CWEA 5GJIA 1O4NA 1SKJA 4FBNA 1RPYA 5EELA 2KK6A 3GXXA 1FYRA 4K44A 3PSJA 1O47A 1O43A 3VS5A 3VS2A 2DM0A 1M27A 4JGHA 3TL0A 2QMSA 3VS1A 1YVLA 1KA7A 2AUGA 1Y1UA 4JE4A 1SPRA 2C0TA 1BFJA 1AYDA 2MC1A 3KFJA 5HKYA 1YVHA 1IS0A 4E93A 3EACA 5EHPA 1GHUA 1BHHB 4OHEA 5EG3B 1OO3A 1K9AA 3EAZA 2K79B 1I3ZA 1BLJA 1HCTB 1KSWA 2B3OA 1FMKA 4GL9E 2DVJA 2Y3AB 5KAZA 4NWFA 3IMJA 3VS6A 1KA6A 4GWFA 1O46A 1R1PA 2CI9A 1FU6A 1Y57A 1AD5A 2EU0A 4EIHA 5I6VA 3MXCA 5EEQA 1O4BA 1TCEA 1RJAA 1BM2A 1AYCA 3US4A 2HDVA 1LUIA 3NHNA 2EKXA 1AB2A 3BUOB 1O4AA 2MRKA 1IJRA 2GE9A 2SRCA 3VGOA 3OV1A 1P13A 1BKMA 2LNWA 2GSBA 3S8LA 4OHHA 3GXWA 3WA4A 1JYRA 3CD3A 1BFIA 2VIFA 2Y1NA 3BKBA 3N84A 2EL8A 2ETZA 2EYYA 3N7YA 5AXIA 4OHLA 1OPKA 2IUGA 3MAZA 1X27A 1PICA 2L4KA 4P9ZA 3S8OA 5HKWA 1A1EA 2SHPA 3PJPA 2CRHA 1LUKA 3M7FA 1O4RA 1MW4A 1OPLA 2IUHA 1LCJA 3GQIB 3HCKA 5IBMA 4FL2A 3UYOA 1H9OA 4E68A 2HCKA 3N8MA 1O4JA 2ECDA 1SHDA 1O41A 3CWGA 2IZVA 1F1WA 2LNXA 2H8HA 2CS0A 1UUSA 3OB1B 1O49A 1QADA 1D4WA 1SHBA 1G83A 2LQNA 3BUMB 2PTKA 3MXYA 4F5BA 3CXLA 4DGXA 4K2RA 3OVEA 4K11A 2LCTA 1CJ1A 2C0IA 2HDXA 3PFVA 1O4PA 4M4ZA 1A09A 1A1AA 3VRPA 4QSYA 4X6SA 2OQ1A 4FL3A 2Y1MA 2HUWA 1FU5A 1NRVA 2KNOA 3PSKA 2DLYA 2EYZA 2FCIA 2PNAA 2DCRA 1M61A 2CR4A 1HCSB 1O4MA 1LUMA 1O4GA 2C9WA 3PS5A 4P9VA 1FBZA 3PQZA 1O44A 4H34A 3C7IA 1LUNA 3VS7A 1LCKA 1UURA 1O4IA 3BUWB 2EO3A 3VRNA 2LQWA 2PLEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FHS A;  3QWX X;  4A4B A;  1O4Q A;  1R1S A;  2RVF A;  4JEG A;  1FBV A;  2PNB A;  2FO0 A;  4L1B B;  1NZV A;  4U1P A;  4H1O A;  4XZ1 A;  5GJH A;  3VRQ A;  1BF5 A;  1ZFP E;  3IMD A;  3IN8 A;  1JYU A;  1A81 A;  1JWO A;  1QCF A;  4XZ0 A;  4DGP A;  4GPL B;  4LUE A;  2AOB A;  1A07 A;  1D4T A;  5AUL A;  5HKZ A;  4ROJ A;  5D0J A;  1O48 A;  3ZNI A;  3VRZ A;  2AOA A;  1BG1 A;  1WQU A;  1X6C A;  2RSY A;  4D8K A;  4WWQ A;  2CIA A;  4EY0 A;  1QG1 E;  2BBU A;  1BKL A;  3IN7 A;  1SPS A;  3VS4 A;  2CI8 A;  1AOT F;  2EOB A;  1O4E A;  1AYB A;  2L3T A;  1BHH A;  4A4C A;  5DC4 A;  1CWD L;  5CDW A;  3BUN B;  2C0O A;  1JYQ A;  2DX0 A;  1BHF A;  3PLF B;  1TZE E;  2DLZ A;  1O4L A;  3HIZ B;  1Z3K A;  3VRO A;  3CBL A;  1O4K A;  2PLD A;  2IUI A;  4U17 A;  1BLK A;  1CSY A;  3VRY A;  5BO4 A;  2MQI A;  1SHA A;  2ROR A;  3OP0 A;  2RMX A;  2XP1 A;  3S8N A;  5DF6 A;  1XA6 A;  1O4C A;  3VS3 A;  1AYA A;  1JU5 A;  2H46 E;  5DC9 A;  2K7A B;  1BMB A;  1F2F A;  1MIL A;  4F5A A;  1A08 A;  5IBS A;  1O4F A;  4OHD A;  3BUX B;  4F59 A;  1O45 A;  2HMH A;  2EO6 A;  2MRJ A;  1LKL A;  1CSZ A;  3VRR A;  1D1Z A;  1A1C A;  2MK2 A;  1KC2 A;  1NZL A;  2H5K A;  3VS0 A;  1O4O A;  1RQQ C;  3HHM B;  1A1B A;  1R1Q A;  2EYV A;  4TZI A;  5DC0 B;  1AOU F;  1O4D A;  4LUD A;  2YSX A;  2L6K A;  3OB2 B;  3TKZ A;  2ABL A;  2JYQ A;  3QWY A;  2CBL A;  4K45 A;  1B47 A;  3UF4 A;  1O42 A;  1GRI A;  3K2M A;  3T04 A;  4OHI A;  4NWG A;  3S9K A;  2YU7 A;  1O4H A;  1X0N A;  5EHR A;  1OO4 A;  1LKK A;  5J3X A;  2OZO A;  1CWE A;  5GJI A;  1O4N A;  1SKJ A;  4FBN A;  1RPY A;  5EEL A;  2KK6 A;  3GXX A;  1FYR A;  4K44 A;  3PSJ A;  1O47 A;  1O43 A;  3VS5 A;  3VS2 A;  2DM0 A;  1M27 A;  4JGH A;  3TL0 A;  2QMS A;  3VS1 A;  1YVL A;  1KA7 A;  2AUG A;  1Y1U A;  4JE4 A;  1SPR A;  2C0T A;  1BFJ A;  1AYD A;  2MC1 A;  3KFJ A;  5HKY A;  1YVH A;  1IS0 A;  4E93 A;  3EAC A;  5EHP A;  1GHU A;  1BHH B;  4OHE A;  5EG3 B;  1OO3 A;  1K9A A;  3EAZ A;  2K79 B;  1I3Z A;  1BLJ A;  1HCT B;  1KSW A;  2B3O A;  1FMK A;  4GL9 E;  2DVJ A;  2Y3A B;  5KAZ A;  4NWF A;  3IMJ A;  3VS6 A;  1KA6 A;  4GWF A;  1O46 A;  1R1P A;  2CI9 A;  1FU6 A;  1Y57 A;  1AD5 A;  2EU0 A;  4EIH A;  5I6V A;  3MXC A;  5EEQ A;  1O4B A;  1TCE A;  1RJA A;  1BM2 A;  1AYC A;  3US4 A;  2HDV A;  1LUI A;  3NHN A;  2EKX A;  1AB2 A;  3BUO B;  1O4A A;  2MRK A;  1IJR A;  2GE9 A;  2SRC A;  3VGO A;  3OV1 A;  1P13 A;  1BKM A;  2LNW A;  2GSB A;  3S8L A;  4OHH A;  3GXW A;  3WA4 A;  1JYR A;  3CD3 A;  1BFI A;  2VIF A;  2Y1N A;  3BKB A;  3N84 A;  2EL8 A;  2ETZ A;  2EYY A;  3N7Y A;  5AXI A;  4OHL A;  1OPK A;  2IUG A;  3MAZ A;  1X27 A;  1PIC A;  2L4K A;  4P9Z A;  3S8O A;  5HKW A;  1A1E A;  2SHP A;  3PJP A;  2CRH A;  1LUK A;  3M7F A;  1O4R A;  1MW4 A;  1OPL A;  2IUH A;  1LCJ A;  3GQI B;  3HCK A;  5IBM A;  4FL2 A;  3UYO A;  1H9O A;  4E68 A;  2HCK A;  3N8M A;  1O4J A;  2ECD A;  1SHD A;  1O41 A;  3CWG A;  2IZV A;  1F1W A;  2LNX A;  2H8H A;  2CS0 A;  1UUS A;  3OB1 B;  1O49 A;  1QAD A;  1D4W A;  1SHB A;  1G83 A;  2LQN A;  3BUM B;  2PTK A;  3MXY A;  4F5B A;  3CXL A;  4DGX A;  4K2R A;  3OVE A;  4K11 A;  2LCT A;  1CJ1 A;  2C0I A;  2HDX A;  3PFV A;  1O4P A;  4M4Z A;  1A09 A;  1A1A A;  3VRP A;  4QSY A;  4X6S A;  2OQ1 A;  4FL3 A;  2Y1M A;  2HUW A;  1FU5 A;  1NRV A;  2KNO A;  3PSK A;  2DLY A;  2EYZ A;  2FCI A;  2PNA A;  2DCR A;  1M61 A;  2CR4 A;  1HCS B;  1O4M A;  1LUM A;  1O4G A;  2C9W A;  3PS5 A;  4P9V A;  1FBZ A;  3PQZ A;  1O44 A;  4H34 A;  3C7I A;  1LUN A;  3VS7 A;  1LCK A;  1UUR A;  1O4I A;  3BUW B;  2EO3 A;  3VRN A;  2LQW A;  2PLE A; 
#chains in the Genus database with same CATH topology
 1FHS A;  3QWX X;  4A4B A;  1O4Q A;  1R1S A;  2RVF A;  4JEG A;  1FBV A;  2LRA A;  2PNB A;  2FO0 A;  4L1B B;  1NZV A;  4U1P A;  4H1O A;  3K2T A;  4XZ1 A;  5GJH A;  3VRQ A;  1BF5 A;  1ZFP E;  3IMD A;  3IN8 A;  1JYU A;  1A81 A;  1JWO A;  1QCF A;  4XZ0 A;  4DGP A;  4GPL B;  4LUE A;  2AOB A;  1A07 A;  1D4T A;  5AUL A;  5HKZ A;  4ROJ A;  2KGY A;  5D0J A;  1O48 A;  3ZNI A;  3VRZ A;  2AOA A;  1BG1 A;  1WQU A;  1X6C A;  2RSY A;  4D8K A;  4WWQ A;  2CIA A;  4EY0 A;  1QG1 E;  2BBU A;  1BKL A;  3IN7 A;  1SPS A;  3VS4 A;  2CI8 A;  1AOT F;  2EOB A;  1O4E A;  1AYB A;  2L3T A;  1BHH A;  4A4C A;  5DC4 A;  1CWD L;  5CDW A;  3BUN B;  2C0O A;  1JYQ A;  2DX0 A;  1BHF A;  3PLF B;  1TZE E;  2DLZ A;  1O4L A;  3HIZ B;  1Z3K A;  3VRO A;  3CBL A;  1O4K A;  2PLD A;  2IUI A;  4U17 A;  1BLK A;  1CSY A;  3VRY A;  5BO4 A;  2MQI A;  1SHA A;  2ROR A;  3OP0 A;  2RMX A;  2XP1 A;  3S8N A;  5DF6 A;  1XA6 A;  1O4C A;  3VS3 A;  1AYA A;  1JU5 A;  2H46 E;  5DC9 A;  2K7A B;  1BMB A;  1F2F A;  1MIL A;  4F5A A;  1A08 A;  5IBS A;  1O4F A;  4OHD A;  3BUX B;  4F59 A;  1O45 A;  2HMH A;  2EO6 A;  2MRJ A;  1LKL A;  1CSZ A;  3VRR A;  1D1Z A;  1A1C A;  2MK2 A;  1KC2 A;  1NZL A;  2H5K A;  3VS0 A;  1O4O A;  1RQQ C;  3HHM B;  1A1B A;  1R1Q A;  2EYV A;  4TZI A;  5DC0 B;  1AOU F;  1O4D A;  4LUD A;  2YSX A;  2L6K A;  3OB2 B;  3TKZ A;  2ABL A;  2JYQ A;  3QWY A;  2CBL A;  4K45 A;  1B47 A;  3UF4 A;  1O42 A;  1GRI A;  3K2M A;  3T04 A;  4OHI A;  4NWG A;  3S9K A;  2YU7 A;  1O4H A;  1X0N A;  5EHR A;  1OO4 A;  1LKK A;  5J3X A;  2OZO A;  1CWE A;  5GJI A;  1O4N A;  1SKJ A;  4FBN A;  1RPY A;  5EEL A;  2KK6 A;  3GXX A;  1FYR A;  4K44 A;  3PSJ A;  1O47 A;  1O43 A;  3VS5 A;  3VS2 A;  2DM0 A;  1M27 A;  4JGH A;  3TL0 A;  2QMS A;  3VS1 A;  1YVL A;  1KA7 A;  2AUG A;  1Y1U A;  4JE4 A;  1SPR A;  2C0T A;  1BFJ A;  1AYD A;  2MC1 A;  3KFJ A;  5HKY A;  1YVH A;  1IS0 A;  4E93 A;  3EAC A;  5EHP A;  1GHU A;  1BHH B;  4OHE A;  5EG3 B;  1OO3 A;  1K9A A;  3EAZ A;  2K79 B;  1I3Z A;  1BLJ A;  1HCT B;  1KSW A;  2B3O A;  1FMK A;  4GL9 E;  2DVJ A;  2Y3A B;  5KAZ A;  4NWF A;  3IMJ A;  3VS6 A;  1KA6 A;  4GWF A;  1O46 A;  1R1P A;  2CI9 A;  1FU6 A;  1Y57 A;  1AD5 A;  2EU0 A;  4EIH A;  5I6V A;  3MXC A;  5EEQ A;  1O4B A;  1TCE A;  1RJA A;  1BM2 A;  1AYC A;  3US4 A;  2HDV A;  1LUI A;  3NHN A;  2EKX A;  1AB2 A;  3BUO B;  1O4A A;  2MRK A;  1IJR A;  2GE9 A;  2SRC A;  3VGO A;  3OV1 A;  1P13 A;  1BKM A;  2LNW A;  2GSB A;  3S8L A;  4OHH A;  3GXW A;  3WA4 A;  1JYR A;  3CD3 A;  1BFI A;  2VIF A;  2Y1N A;  3BKB A;  3N84 A;  2EL8 A;  2ETZ A;  2EYY A;  3N7Y A;  5AXI A;  4OHL A;  1OPK A;  2IUG A;  3MAZ A;  1X27 A;  1PIC A;  2L4K A;  4P9Z A;  3S8O A;  5HKW A;  1A1E A;  2SHP A;  3PJP A;  2CRH A;  1LUK A;  3M7F A;  1O4R A;  1MW4 A;  1OPL A;  2IUH A;  1LCJ A;  3GQI B;  3HCK A;  5IBM A;  4FL2 A;  3UYO A;  1H9O A;  4E68 A;  2HCK A;  3N8M A;  1O4J A;  2ECD A;  1SHD A;  1O41 A;  3CWG A;  2IZV A;  1F1W A;  2LNX A;  2H8H A;  2CS0 A;  1UUS A;  3OB1 B;  1O49 A;  1QAD A;  1D4W A;  1SHB A;  1G83 A;  2LQN A;  3BUM B;  2PTK A;  3MXY A;  4F5B A;  3CXL A;  4DGX A;  4K2R A;  3OVE A;  4K11 A;  2LCT A;  1CJ1 A;  2C0I A;  2HDX A;  3PFV A;  1O4P A;  4M4Z A;  1A09 A;  1A1A A;  3VRP A;  4QSY A;  4X6S A;  2OQ1 A;  4FL3 A;  2Y1M A;  2HUW A;  1FU5 A;  1NRV A;  2KNO A;  3PSK A;  2DLY A;  2EYZ A;  2FCI A;  2PNA A;  2DCR A;  1M61 A;  2CR4 A;  1HCS B;  1O4M A;  1LUM A;  1O4G A;  2C9W A;  3PS5 A;  4P9V A;  1FBZ A;  3LYV A;  3PQZ A;  1O44 A;  4H34 A;  3C7I A;  1LUN A;  3VS7 A;  1LCK A;  1UUR A;  1O4I A;  3BUW B;  2EO3 A;  3VRN A;  2LQW A;  2PLE A; 
#chains in the Genus database with same CATH homology
 1FHS A;  3QWX X;  4A4B A;  1O4Q A;  1R1S A;  2RVF A;  4JEG A;  1FBV A;  2PNB A;  2FO0 A;  4L1B B;  1NZV A;  4U1P A;  4H1O A;  4XZ1 A;  5GJH A;  3VRQ A;  1BF5 A;  1ZFP E;  3IMD A;  3IN8 A;  1JYU A;  1A81 A;  1JWO A;  1QCF A;  4XZ0 A;  4DGP A;  4GPL B;  4LUE A;  2AOB A;  1A07 A;  1D4T A;  5AUL A;  5HKZ A;  4ROJ A;  5D0J A;  1O48 A;  3ZNI A;  3VRZ A;  2AOA A;  1BG1 A;  1WQU A;  1X6C A;  2RSY A;  4D8K A;  4WWQ A;  2CIA A;  4EY0 A;  1QG1 E;  2BBU A;  1BKL A;  3IN7 A;  1SPS A;  3VS4 A;  2CI8 A;  1AOT F;  2EOB A;  1O4E A;  1AYB A;  2L3T A;  1BHH A;  4A4C A;  5DC4 A;  1CWD L;  5CDW A;  3BUN B;  2C0O A;  1JYQ A;  2DX0 A;  1BHF A;  3PLF B;  1TZE E;  2DLZ A;  1O4L A;  3HIZ B;  1Z3K A;  3VRO A;  3CBL A;  1O4K A;  2PLD A;  2IUI A;  4U17 A;  1BLK A;  1CSY A;  3VRY A;  5BO4 A;  2MQI A;  1SHA A;  2ROR A;  3OP0 A;  2RMX A;  2XP1 A;  3S8N A;  5DF6 A;  1XA6 A;  1O4C A;  3VS3 A;  1AYA A;  1JU5 A;  2H46 E;  5DC9 A;  2K7A B;  1BMB A;  1F2F A;  1MIL A;  4F5A A;  1A08 A;  5IBS A;  1O4F A;  4OHD A;  3BUX B;  4F59 A;  1O45 A;  2HMH A;  2EO6 A;  2MRJ A;  1LKL A;  1CSZ A;  3VRR A;  1D1Z A;  1A1C A;  2MK2 A;  1KC2 A;  1NZL A;  2H5K A;  3VS0 A;  1O4O A;  1RQQ C;  3HHM B;  1A1B A;  1R1Q A;  2EYV A;  4TZI A;  5DC0 B;  1AOU F;  1O4D A;  4LUD A;  2YSX A;  2L6K A;  3OB2 B;  3TKZ A;  2ABL A;  2JYQ A;  3QWY A;  2CBL A;  4K45 A;  1B47 A;  3UF4 A;  1O42 A;  1GRI A;  3K2M A;  3T04 A;  4OHI A;  4NWG A;  3S9K A;  2YU7 A;  1O4H A;  1X0N A;  5EHR A;  1OO4 A;  1LKK A;  5J3X A;  2OZO A;  1CWE A;  5GJI A;  1O4N A;  1SKJ A;  4FBN A;  1RPY A;  5EEL A;  2KK6 A;  3GXX A;  1FYR A;  4K44 A;  3PSJ A;  1O47 A;  1O43 A;  3VS5 A;  3VS2 A;  2DM0 A;  1M27 A;  4JGH A;  3TL0 A;  2QMS A;  3VS1 A;  1YVL A;  1KA7 A;  2AUG A;  1Y1U A;  4JE4 A;  1SPR A;  2C0T A;  1BFJ A;  1AYD A;  2MC1 A;  3KFJ A;  5HKY A;  1YVH A;  1IS0 A;  4E93 A;  3EAC A;  5EHP A;  1GHU A;  1BHH B;  4OHE A;  5EG3 B;  1OO3 A;  1K9A A;  3EAZ A;  2K79 B;  1I3Z A;  1BLJ A;  1HCT B;  1KSW A;  2B3O A;  1FMK A;  4GL9 E;  2DVJ A;  2Y3A B;  5KAZ A;  4NWF A;  3IMJ A;  3VS6 A;  1KA6 A;  4GWF A;  1O46 A;  1R1P A;  2CI9 A;  1FU6 A;  1Y57 A;  1AD5 A;  2EU0 A;  4EIH A;  5I6V A;  3MXC A;  5EEQ A;  1O4B A;  1TCE A;  1RJA A;  1BM2 A;  1AYC A;  3US4 A;  2HDV A;  1LUI A;  3NHN A;  2EKX A;  1AB2 A;  3BUO B;  1O4A A;  2MRK A;  1IJR A;  2GE9 A;  2SRC A;  3VGO A;  3OV1 A;  1P13 A;  1BKM A;  2LNW A;  2GSB A;  3S8L A;  4OHH A;  3GXW A;  3WA4 A;  1JYR A;  3CD3 A;  1BFI A;  2VIF A;  2Y1N A;  3BKB A;  3N84 A;  2EL8 A;  2ETZ A;  2EYY A;  3N7Y A;  5AXI A;  4OHL A;  1OPK A;  2IUG A;  3MAZ A;  1X27 A;  1PIC A;  2L4K A;  4P9Z A;  3S8O A;  5HKW A;  1A1E A;  2SHP A;  3PJP A;  2CRH A;  1LUK A;  3M7F A;  1O4R A;  1MW4 A;  1OPL A;  2IUH A;  1LCJ A;  3GQI B;  3HCK A;  5IBM A;  4FL2 A;  3UYO A;  1H9O A;  4E68 A;  2HCK A;  3N8M A;  1O4J A;  2ECD A;  1SHD A;  1O41 A;  3CWG A;  2IZV A;  1F1W A;  2LNX A;  2H8H A;  2CS0 A;  1UUS A;  3OB1 B;  1O49 A;  1QAD A;  1D4W A;  1SHB A;  1G83 A;  2LQN A;  3BUM B;  2PTK A;  3MXY A;  4F5B A;  3CXL A;  4DGX A;  4K2R A;  3OVE A;  4K11 A;  2LCT A;  1CJ1 A;  2C0I A;  2HDX A;  3PFV A;  1O4P A;  4M4Z A;  1A09 A;  1A1A A;  3VRP A;  4QSY A;  4X6S A;  2OQ1 A;  4FL3 A;  2Y1M A;  2HUW A;  1FU5 A;  1NRV A;  2KNO A;  3PSK A;  2DLY A;  2EYZ A;  2FCI A;  2PNA A;  2DCR A;  1M61 A;  2CR4 A;  1HCS B;  1O4M A;  1LUM A;  1O4G A;  2C9W A;  3PS5 A;  4P9V A;  1FBZ A;  3PQZ A;  1O44 A;  4H34 A;  3C7I A;  1LUN A;  3VS7 A;  1LCK A;  1UUR A;  1O4I A;  3BUW B;  2EO3 A;  3VRN A;  2LQW A;  2PLE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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