2AOAA

Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the grb2 sh2 domain
Total Genus 19
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
19
sequence length
93
structure length
93
Chain Sequence
HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Growth factor receptor-bound protein 2
total genus 19
structure length 93
sequence length 93
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-08-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00017 SH2 SH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 2aoaA00
3TL0A 2EYYA 3M7FA 4OHHA 2H5KA 4E93A 3BUWB 3VGOA 2C0IA 1HCSB 2C0TA 1O4OA 3VS7A 4EIHA 1BFJA 3MAZA 1IS0A 1TZEE 1TCEA 5EEQA 3K2MA 5KAZA 5DF6A 3PLFB 2DVJA 1AOUF 1A1AA 4LUEA 3BKBA 1RJAA 1LUIA 1SHAA 2LQWA 1O4MA 5HKWA 3MXYA 1RPYA 2IUGA 1SPRA 1Y57A 2EKXA 2JYQA 2L3TA 2CRHA 1A1EA 1O4PA 2CI8A 1FU5A 1LCJA 5EELA 3ZNIA 4H34A 1A09A 4OHDA 1O43A 3VS6A 4H1OA 1D1ZA 5DC0B 3UYOA 2AUGA 2ABLA 1BG1A 1FU6A 1FHSA 1O4QA 4OHEA 3C7IA 5EG3B 3VRRA 1QADA 1OO3A 1O4HA 1P13A 3VS1A 3BUXB 1A08A 1LUNA 2LNXA 1R1PA 4X6SA 5IBMA 1LCKA 4TZIA 1SPSA 4K45A 1IJRA 3OB2B 1A07A 1JYRA 1LUMA 1O4AA 3VS4A 3T04A 2MRJA 4K44A 5CDWA 1O47A 2YU7A 2GE9A 3PJPA 1BKMA 1O49A 2VIFA 3IMJA 1LKLA 5J3XA 2LCTA 1X27A 2CBLA 1O4BA 1O4RA 1PICA 2ETZA 3VRZA 1M61A 4OHLA 1O48A 2CR4A 3NHNA 1UUSA 3GXXA 1CJ1A 3OVEA 1LKKA 3S9KA 1NRVA 3S8LA 2HCKA 1F2FA 5AXIA 1YVHA 2Y1NA 1QCFA 2EO6A 2MC1A 2RSYA 1O46A 1SHDA 1F1WA 3WA4A 2B3OA 3VROA 2L6KA 1JU5A 2SRCA 1K9AA 1G83A 2QMSA 1RQQC 2FCIA 3N84A 2OQ1A 3VS3A 1A1BA 3HIZB 1BHHB 1BF5A 2GSBA 1ZFPE 1A81A 1MW4A 3CBLA 2MQIA 1FBZA 5IBSA 4GPLB 3BUOB 5HKYA 2IZVA 2DX0A 1BHHA 5DC4A 4U1PA 1CSZA 1QG1E 2EYZA 3CWGA 3HCKA 2AOBA 1R1QA 1LUKA 2Y1MA 2OZOA 4JGHA 4U17A 4A4BA 3GQIB 4P9ZA 2L4KA 1KSWA 1AYCA 2CIAA 2K7AB 2MRKA 2ECDA 3EAZA 1O4LA 1BLKA 1YVLA 2EO3A 1FYRA 5GJIA 1FBVA 1H9OA 5BO4A 1AYBA 2H8HA 5EHPA 4JEGA 3S8NA 1R1SA 4F5AA 1FMKA 4NWGA 1HCTB 2LQNA 1BMBA 2PTKA 1O45A 3PSJA 3GXWA 3N7YA 3PS5A 3S8OA 1JWOA 1WQUA 1XA6A 1O41A 2AOAA 2Y3AB 1X6CA 3VS5A 3TKZA 1X0NA 2PNBA 1JYUA 1UURA 2MK2A 3IN8A 1BFIA 3HHMB 2PNAA 1A1CA 2DLZA 3PFVA 4D8KA 4NWFA 1BKLA 3QWXX 3OB1B 5D0JA 1O4EA 1CSYA 1OPKA 4QSYA 1AYDA 1AYAA 1BHFA 3PSKA 2C0OA 2EYVA 2BBUA 1OO4A 4A4CA 2YSXA 1D4WA 4FL2A 1KA7A 2C9WA 5DC9A 4F5BA 3IN7A 2RMXA 3CD3A 1MILA 3VRYA 4P9VA 4L1BB 4K11A 3KFJA 4ROJA 1GRIA 1KA6A 2HMHA 3IMDA 1Z3KA 1AOTF 1Y1UA 2HDVA 1O4KA 4XZ0A 1JYQA 3OP0A 1O4CA 1O4NA 2FO0A 5AULA 1CWEA 4DGXA 1BM2A 2PLEA 1D4TA 3CXLA 4XZ1A 1O4FA 1GHUA 5I6VA 2SHPA 3BUNB 2K79B 4WWQA 4GL9E 1AB2A 2RVFA 1M27A 2HDXA 1KC2A 4JE4A 4EY0A 4E68A 2KNOA 2PLDA 3VRNA 5EHRA 2DLYA 1SHBA 3PQZA 3VS0A 4M4ZA 3N8MA 2DCRA 2CI9A 1CWDL 2H46E 1NZLA 1SKJA 4OHIA 1O44A 3OV1A 4FL3A 2EL8A 1O4GA 1BLJA 1OPLA 2RORA 2CS0A 1O4DA 3UF4A 2XP1A 4K2RA 1O4IA 3VS2A 4DGPA 1NZVA 3VRQA 2IUHA 3VRPA 4F59A 1I3ZA 3BUMB 1AD5A 3MXCA 2LNWA 4LUDA 5GJHA 5HKZA 1B47A 1O42A 1O4JA 2HUWA 4FBNA 3US4A 3QWYA 4GWFA 2EU0A 2KK6A 3EACA 2DM0A 2IUIA 2EOBA
chains in the Genus database with same CATH superfamily
3TL0A 2EYYA 3M7FA 4OHHA 2H5KA 4E93A 3BUWB 3VGOA 2C0IA 1HCSB 2C0TA 1O4OA 3VS7A 4EIHA 1BFJA 3MAZA 1IS0A 1TZEE 1TCEA 5EEQA 3K2MA 5KAZA 5DF6A 3PLFB 2DVJA 1AOUF 1A1AA 4LUEA 3BKBA 1RJAA 1LUIA 1SHAA 2LQWA 1O4MA 5HKWA 3MXYA 1RPYA 2IUGA 1SPRA 1Y57A 2EKXA 2JYQA 2L3TA 2CRHA 1A1EA 1O4PA 2CI8A 1FU5A 1LCJA 5EELA 3ZNIA 4H34A 1A09A 4OHDA 1O43A 3VS6A 4H1OA 1D1ZA 5DC0B 3UYOA 2AUGA 2ABLA 1BG1A 1FU6A 1FHSA 1O4QA 4OHEA 3C7IA 5EG3B 3VRRA 1QADA 1OO3A 1O4HA 1P13A 3VS1A 3BUXB 1A08A 1LUNA 2LNXA 1R1PA 4X6SA 5IBMA 1LCKA 4TZIA 1SPSA 4K45A 1IJRA 3OB2B 1A07A 1JYRA 1LUMA 1O4AA 3VS4A 3T04A 2MRJA 4K44A 5CDWA 1O47A 3LYVA 2YU7A 2GE9A 3PJPA 1BKMA 1O49A 2VIFA 3IMJA 1LKLA 5J3XA 2LCTA 1X27A 2CBLA 1O4BA 1O4RA 1PICA 2ETZA 3VRZA 1M61A 4OHLA 1O48A 2CR4A 3NHNA 1UUSA 3GXXA 1CJ1A 3OVEA 1LKKA 3S9KA 1NRVA 3S8LA 2HCKA 1F2FA 5AXIA 1YVHA 2Y1NA 1QCFA 2EO6A 2MC1A 2RSYA 1O46A 1SHDA 1F1WA 3WA4A 2B3OA 3VROA 2L6KA 1JU5A 2SRCA 1K9AA 1G83A 2QMSA 1RQQC 2FCIA 3N84A 2OQ1A 3VS3A 1A1BA 3HIZB 1BHHB 1BF5A 2GSBA 1ZFPE 1A81A 1MW4A 3CBLA 2MQIA 1FBZA 5IBSA 4GPLB 3BUOB 5HKYA 2IZVA 2DX0A 1BHHA 5DC4A 4U1PA 1CSZA 1QG1E 2EYZA 3CWGA 3HCKA 2AOBA 1R1QA 1LUKA 2Y1MA 2OZOA 4JGHA 4U17A 4A4BA 3GQIB 4P9ZA 2L4KA 1KSWA 1AYCA 2CIAA 2K7AB 2MRKA 2ECDA 3EAZA 1O4LA 1BLKA 1YVLA 2EO3A 1FYRA 5GJIA 1FBVA 1H9OA 5BO4A 1AYBA 2H8HA 5EHPA 4JEGA 3S8NA 1R1SA 4F5AA 1FMKA 4NWGA 1HCTB 2LQNA 1BMBA 2PTKA 3K2TA 1O45A 3PSJA 3GXWA 3N7YA 3PS5A 3S8OA 1JWOA 1WQUA 1XA6A 1O41A 2AOAA 2Y3AB 1X6CA 3VS5A 3TKZA 1X0NA 2PNBA 1JYUA 1UURA 2MK2A 3IN8A 1BFIA 3HHMB 2PNAA 1A1CA 2DLZA 3PFVA 4D8KA 4NWFA 1BKLA 3QWXX 3OB1B 5D0JA 1O4EA 1CSYA 1OPKA 4QSYA 1AYDA 1AYAA 1BHFA 3PSKA 2C0OA 2EYVA 2BBUA 1OO4A 4A4CA 2YSXA 1D4WA 4FL2A 1KA7A 2C9WA 5DC9A 4F5BA 3IN7A 2RMXA 3CD3A 1MILA 3VRYA 4P9VA 4L1BB 4K11A 3KFJA 4ROJA 1GRIA 1KA6A 2LRAA 2HMHA 3IMDA 1Z3KA 1AOTF 1Y1UA 2HDVA 1O4KA 4XZ0A 2KGYA 1JYQA 3OP0A 1O4CA 1O4NA 2FO0A 5AULA 1CWEA 4DGXA 1BM2A 2PLEA 1D4TA 3CXLA 4XZ1A 1O4FA 1GHUA 5I6VA 2SHPA 3BUNB 2K79B 4WWQA 4GL9E 1AB2A 2RVFA 1M27A 2HDXA 1KC2A 4JE4A 4EY0A 4E68A 2KNOA 2PLDA 3VRNA 5EHRA 2DLYA 1SHBA 3PQZA 3VS0A 4M4ZA 3N8MA 2DCRA 2CI9A 1CWDL 2H46E 1NZLA 1SKJA 4OHIA 1O44A 3OV1A 4FL3A 2EL8A 1O4GA 1BLJA 1OPLA 2RORA 2CS0A 1O4DA 3UF4A 2XP1A 4K2RA 1O4IA 3VS2A 4DGPA 1NZVA 3VRQA 2IUHA 3VRPA 4F59A 1I3ZA 3BUMB 1AD5A 3MXCA 2LNWA 4LUDA 5GJHA 5HKZA 1B47A 1O42A 1O4JA 2HUWA 4FBNA 3US4A 3QWYA 4GWFA 2EU0A 2KK6A 3EACA 2DM0A 2IUIA 2EOBA
chains in the Genus database with same CATH topology
3TL0A 2EYYA 3M7FA 4OHHA 2H5KA 4E93A 3BUWB 3VGOA 2C0IA 1HCSB 2C0TA 1O4OA 3VS7A 4EIHA 1BFJA 3MAZA 1IS0A 1TZEE 1TCEA 5EEQA 3K2MA 5KAZA 5DF6A 3PLFB 2DVJA 1AOUF 1A1AA 4LUEA 3BKBA 1RJAA 1LUIA 1SHAA 2LQWA 1O4MA 5HKWA 3MXYA 1RPYA 2IUGA 1SPRA 1Y57A 2EKXA 2JYQA 2L3TA 2CRHA 1A1EA 1O4PA 2CI8A 1FU5A 1LCJA 5EELA 3ZNIA 4H34A 1A09A 4OHDA 1O43A 3VS6A 4H1OA 1D1ZA 5DC0B 3UYOA 2AUGA 2ABLA 1BG1A 1FU6A 1FHSA 1O4QA 4OHEA 3C7IA 5EG3B 3VRRA 1QADA 1OO3A 1O4HA 1P13A 3VS1A 3BUXB 1A08A 1LUNA 2LNXA 1R1PA 4X6SA 5IBMA 1LCKA 4TZIA 1SPSA 4K45A 1IJRA 3OB2B 1A07A 1JYRA 1LUMA 1O4AA 3VS4A 3T04A 2MRJA 4K44A 5CDWA 1O47A 2YU7A 2GE9A 3PJPA 1BKMA 1O49A 2VIFA 3IMJA 1LKLA 5J3XA 2LCTA 1X27A 2CBLA 1O4BA 1O4RA 1PICA 2ETZA 3VRZA 1M61A 4OHLA 1O48A 2CR4A 3NHNA 1UUSA 3GXXA 1CJ1A 3OVEA 1LKKA 3S9KA 1NRVA 3S8LA 2HCKA 1F2FA 5AXIA 1YVHA 2Y1NA 1QCFA 2EO6A 2MC1A 2RSYA 1O46A 1SHDA 1F1WA 3WA4A 2B3OA 3VROA 2L6KA 1JU5A 2SRCA 1K9AA 1G83A 2QMSA 1RQQC 2FCIA 3N84A 2OQ1A 3VS3A 1A1BA 3HIZB 1BHHB 1BF5A 2GSBA 1ZFPE 1A81A 1MW4A 3CBLA 2MQIA 1FBZA 5IBSA 4GPLB 3BUOB 5HKYA 2IZVA 2DX0A 1BHHA 5DC4A 4U1PA 1CSZA 1QG1E 2EYZA 3CWGA 3HCKA 2AOBA 1R1QA 1LUKA 2Y1MA 2OZOA 4JGHA 4U17A 4A4BA 3GQIB 4P9ZA 2L4KA 1KSWA 1AYCA 2CIAA 2K7AB 2MRKA 2ECDA 3EAZA 1O4LA 1BLKA 1YVLA 2EO3A 1FYRA 5GJIA 1FBVA 1H9OA 5BO4A 1AYBA 2H8HA 5EHPA 4JEGA 3S8NA 1R1SA 4F5AA 1FMKA 4NWGA 1HCTB 2LQNA 1BMBA 2PTKA 1O45A 3PSJA 3GXWA 3N7YA 3PS5A 3S8OA 1JWOA 1WQUA 1XA6A 1O41A 2AOAA 2Y3AB 1X6CA 3VS5A 3TKZA 1X0NA 2PNBA 1JYUA 1UURA 2MK2A 3IN8A 1BFIA 3HHMB 2PNAA 1A1CA 2DLZA 3PFVA 4D8KA 4NWFA 1BKLA 3QWXX 3OB1B 5D0JA 1O4EA 1CSYA 1OPKA 4QSYA 1AYDA 1AYAA 1BHFA 3PSKA 2C0OA 2EYVA 2BBUA 1OO4A 4A4CA 2YSXA 1D4WA 4FL2A 1KA7A 2C9WA 5DC9A 4F5BA 3IN7A 2RMXA 3CD3A 1MILA 3VRYA 4P9VA 4L1BB 4K11A 3KFJA 4ROJA 1GRIA 1KA6A 2HMHA 3IMDA 1Z3KA 1AOTF 1Y1UA 2HDVA 1O4KA 4XZ0A 1JYQA 3OP0A 1O4CA 1O4NA 2FO0A 5AULA 1CWEA 4DGXA 1BM2A 2PLEA 1D4TA 3CXLA 4XZ1A 1O4FA 1GHUA 5I6VA 2SHPA 3BUNB 2K79B 4WWQA 4GL9E 1AB2A 2RVFA 1M27A 2HDXA 1KC2A 4JE4A 4EY0A 4E68A 2KNOA 2PLDA 3VRNA 5EHRA 2DLYA 1SHBA 3PQZA 3VS0A 4M4ZA 3N8MA 2DCRA 2CI9A 1CWDL 2H46E 1NZLA 1SKJA 4OHIA 1O44A 3OV1A 4FL3A 2EL8A 1O4GA 1BLJA 1OPLA 2RORA 2CS0A 1O4DA 3UF4A 2XP1A 4K2RA 1O4IA 3VS2A 4DGPA 1NZVA 3VRQA 2IUHA 3VRPA 4F59A 1I3ZA 3BUMB 1AD5A 3MXCA 2LNWA 4LUDA 5GJHA 5HKZA 1B47A 1O42A 1O4JA 2HUWA 4FBNA 3US4A 3QWYA 4GWFA 2EU0A 2KK6A 3EACA 2DM0A 2IUIA 2EOBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TL0 A;  2EYY A;  3M7F A;  4OHH A;  2H5K A;  4E93 A;  3BUW B;  3VGO A;  2C0I A;  1HCS B;  2C0T A;  1O4O A;  3VS7 A;  4EIH A;  1BFJ A;  3MAZ A;  1IS0 A;  1TZE E;  1TCE A;  5EEQ A;  3K2M A;  5KAZ A;  5DF6 A;  3PLF B;  2DVJ A;  1AOU F;  1A1A A;  4LUE A;  3BKB A;  1RJA A;  1LUI A;  1SHA A;  2LQW A;  1O4M A;  5HKW A;  3MXY A;  1RPY A;  2IUG A;  1SPR A;  1Y57 A;  2EKX A;  2JYQ A;  2L3T A;  2CRH A;  1A1E A;  1O4P A;  2CI8 A;  1FU5 A;  1LCJ A;  5EEL A;  3ZNI A;  4H34 A;  1A09 A;  4OHD A;  1O43 A;  3VS6 A;  4H1O A;  1D1Z A;  5DC0 B;  3UYO A;  2AUG A;  2ABL A;  1BG1 A;  1FU6 A;  1FHS A;  1O4Q A;  4OHE A;  3C7I A;  5EG3 B;  3VRR A;  1QAD A;  1OO3 A;  1O4H A;  1P13 A;  3VS1 A;  3BUX B;  1A08 A;  1LUN A;  2LNX A;  1R1P A;  4X6S A;  5IBM A;  1LCK A;  4TZI A;  1SPS A;  4K45 A;  1IJR A;  3OB2 B;  1A07 A;  1JYR A;  1LUM A;  1O4A A;  3VS4 A;  3T04 A;  2MRJ A;  4K44 A;  5CDW A;  1O47 A;  2YU7 A;  2GE9 A;  3PJP A;  1BKM A;  1O49 A;  2VIF A;  3IMJ A;  1LKL A;  5J3X A;  2LCT A;  1X27 A;  2CBL A;  1O4B A;  1O4R A;  1PIC A;  2ETZ A;  3VRZ A;  1M61 A;  4OHL A;  1O48 A;  2CR4 A;  3NHN A;  1UUS A;  3GXX A;  1CJ1 A;  3OVE A;  1LKK A;  3S9K A;  1NRV A;  3S8L A;  2HCK A;  1F2F A;  5AXI A;  1YVH A;  2Y1N A;  1QCF A;  2EO6 A;  2MC1 A;  2RSY A;  1O46 A;  1SHD A;  1F1W A;  3WA4 A;  2B3O A;  3VRO A;  2L6K A;  1JU5 A;  2SRC A;  1K9A A;  1G83 A;  2QMS A;  1RQQ C;  2FCI A;  3N84 A;  2OQ1 A;  3VS3 A;  1A1B A;  3HIZ B;  1BHH B;  1BF5 A;  2GSB A;  1ZFP E;  1A81 A;  1MW4 A;  3CBL A;  2MQI A;  1FBZ A;  5IBS A;  4GPL B;  3BUO B;  5HKY A;  2IZV A;  2DX0 A;  1BHH A;  5DC4 A;  4U1P A;  1CSZ A;  1QG1 E;  2EYZ A;  3CWG A;  3HCK A;  2AOB A;  1R1Q A;  1LUK A;  2Y1M A;  2OZO A;  4JGH A;  4U17 A;  4A4B A;  3GQI B;  4P9Z A;  2L4K A;  1KSW A;  1AYC A;  2CIA A;  2K7A B;  2MRK A;  2ECD A;  3EAZ A;  1O4L A;  1BLK A;  1YVL A;  2EO3 A;  1FYR A;  5GJI A;  1FBV A;  1H9O A;  5BO4 A;  1AYB A;  2H8H A;  5EHP A;  4JEG A;  3S8N A;  1R1S A;  4F5A A;  1FMK A;  4NWG A;  1HCT B;  2LQN A;  1BMB A;  2PTK A;  1O45 A;  3PSJ A;  3GXW A;  3N7Y A;  3PS5 A;  3S8O A;  1JWO A;  1WQU A;  1XA6 A;  1O41 A;  2AOA A;  2Y3A B;  1X6C A;  3VS5 A;  3TKZ A;  1X0N A;  2PNB A;  1JYU A;  1UUR A;  2MK2 A;  3IN8 A;  1BFI A;  3HHM B;  2PNA A;  1A1C A;  2DLZ A;  3PFV A;  4D8K A;  4NWF A;  1BKL A;  3QWX X;  3OB1 B;  5D0J A;  1O4E A;  1CSY A;  1OPK A;  4QSY A;  1AYD A;  1AYA A;  1BHF A;  3PSK A;  2C0O A;  2EYV A;  2BBU A;  1OO4 A;  4A4C A;  2YSX A;  1D4W A;  4FL2 A;  1KA7 A;  2C9W A;  5DC9 A;  4F5B A;  3IN7 A;  2RMX A;  3CD3 A;  1MIL A;  3VRY A;  4P9V A;  4L1B B;  4K11 A;  3KFJ A;  4ROJ A;  1GRI A;  1KA6 A;  2HMH A;  3IMD A;  1Z3K A;  1AOT F;  1Y1U A;  2HDV A;  1O4K A;  4XZ0 A;  1JYQ A;  3OP0 A;  1O4C A;  1O4N A;  2FO0 A;  5AUL A;  1CWE A;  4DGX A;  1BM2 A;  2PLE A;  1D4T A;  3CXL A;  4XZ1 A;  1O4F A;  1GHU A;  5I6V A;  2SHP A;  3BUN B;  2K79 B;  4WWQ A;  4GL9 E;  1AB2 A;  2RVF A;  1M27 A;  2HDX A;  1KC2 A;  4JE4 A;  4EY0 A;  4E68 A;  2KNO A;  2PLD A;  3VRN A;  5EHR A;  2DLY A;  1SHB A;  3PQZ A;  3VS0 A;  4M4Z A;  3N8M A;  2DCR A;  2CI9 A;  1CWD L;  2H46 E;  1NZL A;  1SKJ A;  4OHI A;  1O44 A;  3OV1 A;  4FL3 A;  2EL8 A;  1O4G A;  1BLJ A;  1OPL A;  2ROR A;  2CS0 A;  1O4D A;  3UF4 A;  2XP1 A;  4K2R A;  1O4I A;  3VS2 A;  4DGP A;  1NZV A;  3VRQ A;  2IUH A;  3VRP A;  4F59 A;  1I3Z A;  3BUM B;  1AD5 A;  3MXC A;  2LNW A;  4LUD A;  5GJH A;  5HKZ A;  1B47 A;  1O42 A;  1O4J A;  2HUW A;  4FBN A;  3US4 A;  3QWY A;  4GWF A;  2EU0 A;  2KK6 A;  3EAC A;  2DM0 A;  2IUI A;  2EOB A; 
#chains in the Genus database with same CATH topology
 3TL0 A;  2EYY A;  3M7F A;  4OHH A;  2H5K A;  4E93 A;  3BUW B;  3VGO A;  2C0I A;  1HCS B;  2C0T A;  1O4O A;  3VS7 A;  4EIH A;  1BFJ A;  3MAZ A;  1IS0 A;  1TZE E;  1TCE A;  5EEQ A;  3K2M A;  5KAZ A;  5DF6 A;  3PLF B;  2DVJ A;  1AOU F;  1A1A A;  4LUE A;  3BKB A;  1RJA A;  1LUI A;  1SHA A;  2LQW A;  1O4M A;  5HKW A;  3MXY A;  1RPY A;  2IUG A;  1SPR A;  1Y57 A;  2EKX A;  2JYQ A;  2L3T A;  2CRH A;  1A1E A;  1O4P A;  2CI8 A;  1FU5 A;  1LCJ A;  5EEL A;  3ZNI A;  4H34 A;  1A09 A;  4OHD A;  1O43 A;  3VS6 A;  4H1O A;  1D1Z A;  5DC0 B;  3UYO A;  2AUG A;  2ABL A;  1BG1 A;  1FU6 A;  1FHS A;  1O4Q A;  4OHE A;  3C7I A;  5EG3 B;  3VRR A;  1QAD A;  1OO3 A;  1O4H A;  1P13 A;  3VS1 A;  3BUX B;  1A08 A;  1LUN A;  2LNX A;  1R1P A;  4X6S A;  5IBM A;  1LCK A;  4TZI A;  1SPS A;  4K45 A;  1IJR A;  3OB2 B;  1A07 A;  1JYR A;  1LUM A;  1O4A A;  3VS4 A;  3T04 A;  2MRJ A;  4K44 A;  5CDW A;  1O47 A;  3LYV A;  2YU7 A;  2GE9 A;  3PJP A;  1BKM A;  1O49 A;  2VIF A;  3IMJ A;  1LKL A;  5J3X A;  2LCT A;  1X27 A;  2CBL A;  1O4B A;  1O4R A;  1PIC A;  2ETZ A;  3VRZ A;  1M61 A;  4OHL A;  1O48 A;  2CR4 A;  3NHN A;  1UUS A;  3GXX A;  1CJ1 A;  3OVE A;  1LKK A;  3S9K A;  1NRV A;  3S8L A;  2HCK A;  1F2F A;  5AXI A;  1YVH A;  2Y1N A;  1QCF A;  2EO6 A;  2MC1 A;  2RSY A;  1O46 A;  1SHD A;  1F1W A;  3WA4 A;  2B3O A;  3VRO A;  2L6K A;  1JU5 A;  2SRC A;  1K9A A;  1G83 A;  2QMS A;  1RQQ C;  2FCI A;  3N84 A;  2OQ1 A;  3VS3 A;  1A1B A;  3HIZ B;  1BHH B;  1BF5 A;  2GSB A;  1ZFP E;  1A81 A;  1MW4 A;  3CBL A;  2MQI A;  1FBZ A;  5IBS A;  4GPL B;  3BUO B;  5HKY A;  2IZV A;  2DX0 A;  1BHH A;  5DC4 A;  4U1P A;  1CSZ A;  1QG1 E;  2EYZ A;  3CWG A;  3HCK A;  2AOB A;  1R1Q A;  1LUK A;  2Y1M A;  2OZO A;  4JGH A;  4U17 A;  4A4B A;  3GQI B;  4P9Z A;  2L4K A;  1KSW A;  1AYC A;  2CIA A;  2K7A B;  2MRK A;  2ECD A;  3EAZ A;  1O4L A;  1BLK A;  1YVL A;  2EO3 A;  1FYR A;  5GJI A;  1FBV A;  1H9O A;  5BO4 A;  1AYB A;  2H8H A;  5EHP A;  4JEG A;  3S8N A;  1R1S A;  4F5A A;  1FMK A;  4NWG A;  1HCT B;  2LQN A;  1BMB A;  2PTK A;  3K2T A;  1O45 A;  3PSJ A;  3GXW A;  3N7Y A;  3PS5 A;  3S8O A;  1JWO A;  1WQU A;  1XA6 A;  1O41 A;  2AOA A;  2Y3A B;  1X6C A;  3VS5 A;  3TKZ A;  1X0N A;  2PNB A;  1JYU A;  1UUR A;  2MK2 A;  3IN8 A;  1BFI A;  3HHM B;  2PNA A;  1A1C A;  2DLZ A;  3PFV A;  4D8K A;  4NWF A;  1BKL A;  3QWX X;  3OB1 B;  5D0J A;  1O4E A;  1CSY A;  1OPK A;  4QSY A;  1AYD A;  1AYA A;  1BHF A;  3PSK A;  2C0O A;  2EYV A;  2BBU A;  1OO4 A;  4A4C A;  2YSX A;  1D4W A;  4FL2 A;  1KA7 A;  2C9W A;  5DC9 A;  4F5B A;  3IN7 A;  2RMX A;  3CD3 A;  1MIL A;  3VRY A;  4P9V A;  4L1B B;  4K11 A;  3KFJ A;  4ROJ A;  1GRI A;  1KA6 A;  2LRA A;  2HMH A;  3IMD A;  1Z3K A;  1AOT F;  1Y1U A;  2HDV A;  1O4K A;  4XZ0 A;  2KGY A;  1JYQ A;  3OP0 A;  1O4C A;  1O4N A;  2FO0 A;  5AUL A;  1CWE A;  4DGX A;  1BM2 A;  2PLE A;  1D4T A;  3CXL A;  4XZ1 A;  1O4F A;  1GHU A;  5I6V A;  2SHP A;  3BUN B;  2K79 B;  4WWQ A;  4GL9 E;  1AB2 A;  2RVF A;  1M27 A;  2HDX A;  1KC2 A;  4JE4 A;  4EY0 A;  4E68 A;  2KNO A;  2PLD A;  3VRN A;  5EHR A;  2DLY A;  1SHB A;  3PQZ A;  3VS0 A;  4M4Z A;  3N8M A;  2DCR A;  2CI9 A;  1CWD L;  2H46 E;  1NZL A;  1SKJ A;  4OHI A;  1O44 A;  3OV1 A;  4FL3 A;  2EL8 A;  1O4G A;  1BLJ A;  1OPL A;  2ROR A;  2CS0 A;  1O4D A;  3UF4 A;  2XP1 A;  4K2R A;  1O4I A;  3VS2 A;  4DGP A;  1NZV A;  3VRQ A;  2IUH A;  3VRP A;  4F59 A;  1I3Z A;  3BUM B;  1AD5 A;  3MXC A;  2LNW A;  4LUD A;  5GJH A;  5HKZ A;  1B47 A;  1O42 A;  1O4J A;  2HUW A;  4FBN A;  3US4 A;  3QWY A;  4GWF A;  2EU0 A;  2KK6 A;  3EAC A;  2DM0 A;  2IUI A;  2EOB A; 
#chains in the Genus database with same CATH homology
 3TL0 A;  2EYY A;  3M7F A;  4OHH A;  2H5K A;  4E93 A;  3BUW B;  3VGO A;  2C0I A;  1HCS B;  2C0T A;  1O4O A;  3VS7 A;  4EIH A;  1BFJ A;  3MAZ A;  1IS0 A;  1TZE E;  1TCE A;  5EEQ A;  3K2M A;  5KAZ A;  5DF6 A;  3PLF B;  2DVJ A;  1AOU F;  1A1A A;  4LUE A;  3BKB A;  1RJA A;  1LUI A;  1SHA A;  2LQW A;  1O4M A;  5HKW A;  3MXY A;  1RPY A;  2IUG A;  1SPR A;  1Y57 A;  2EKX A;  2JYQ A;  2L3T A;  2CRH A;  1A1E A;  1O4P A;  2CI8 A;  1FU5 A;  1LCJ A;  5EEL A;  3ZNI A;  4H34 A;  1A09 A;  4OHD A;  1O43 A;  3VS6 A;  4H1O A;  1D1Z A;  5DC0 B;  3UYO A;  2AUG A;  2ABL A;  1BG1 A;  1FU6 A;  1FHS A;  1O4Q A;  4OHE A;  3C7I A;  5EG3 B;  3VRR A;  1QAD A;  1OO3 A;  1O4H A;  1P13 A;  3VS1 A;  3BUX B;  1A08 A;  1LUN A;  2LNX A;  1R1P A;  4X6S A;  5IBM A;  1LCK A;  4TZI A;  1SPS A;  4K45 A;  1IJR A;  3OB2 B;  1A07 A;  1JYR A;  1LUM A;  1O4A A;  3VS4 A;  3T04 A;  2MRJ A;  4K44 A;  5CDW A;  1O47 A;  2YU7 A;  2GE9 A;  3PJP A;  1BKM A;  1O49 A;  2VIF A;  3IMJ A;  1LKL A;  5J3X A;  2LCT A;  1X27 A;  2CBL A;  1O4B A;  1O4R A;  1PIC A;  2ETZ A;  3VRZ A;  1M61 A;  4OHL A;  1O48 A;  2CR4 A;  3NHN A;  1UUS A;  3GXX A;  1CJ1 A;  3OVE A;  1LKK A;  3S9K A;  1NRV A;  3S8L A;  2HCK A;  1F2F A;  5AXI A;  1YVH A;  2Y1N A;  1QCF A;  2EO6 A;  2MC1 A;  2RSY A;  1O46 A;  1SHD A;  1F1W A;  3WA4 A;  2B3O A;  3VRO A;  2L6K A;  1JU5 A;  2SRC A;  1K9A A;  1G83 A;  2QMS A;  1RQQ C;  2FCI A;  3N84 A;  2OQ1 A;  3VS3 A;  1A1B A;  3HIZ B;  1BHH B;  1BF5 A;  2GSB A;  1ZFP E;  1A81 A;  1MW4 A;  3CBL A;  2MQI A;  1FBZ A;  5IBS A;  4GPL B;  3BUO B;  5HKY A;  2IZV A;  2DX0 A;  1BHH A;  5DC4 A;  4U1P A;  1CSZ A;  1QG1 E;  2EYZ A;  3CWG A;  3HCK A;  2AOB A;  1R1Q A;  1LUK A;  2Y1M A;  2OZO A;  4JGH A;  4U17 A;  4A4B A;  3GQI B;  4P9Z A;  2L4K A;  1KSW A;  1AYC A;  2CIA A;  2K7A B;  2MRK A;  2ECD A;  3EAZ A;  1O4L A;  1BLK A;  1YVL A;  2EO3 A;  1FYR A;  5GJI A;  1FBV A;  1H9O A;  5BO4 A;  1AYB A;  2H8H A;  5EHP A;  4JEG A;  3S8N A;  1R1S A;  4F5A A;  1FMK A;  4NWG A;  1HCT B;  2LQN A;  1BMB A;  2PTK A;  1O45 A;  3PSJ A;  3GXW A;  3N7Y A;  3PS5 A;  3S8O A;  1JWO A;  1WQU A;  1XA6 A;  1O41 A;  2AOA A;  2Y3A B;  1X6C A;  3VS5 A;  3TKZ A;  1X0N A;  2PNB A;  1JYU A;  1UUR A;  2MK2 A;  3IN8 A;  1BFI A;  3HHM B;  2PNA A;  1A1C A;  2DLZ A;  3PFV A;  4D8K A;  4NWF A;  1BKL A;  3QWX X;  3OB1 B;  5D0J A;  1O4E A;  1CSY A;  1OPK A;  4QSY A;  1AYD A;  1AYA A;  1BHF A;  3PSK A;  2C0O A;  2EYV A;  2BBU A;  1OO4 A;  4A4C A;  2YSX A;  1D4W A;  4FL2 A;  1KA7 A;  2C9W A;  5DC9 A;  4F5B A;  3IN7 A;  2RMX A;  3CD3 A;  1MIL A;  3VRY A;  4P9V A;  4L1B B;  4K11 A;  3KFJ A;  4ROJ A;  1GRI A;  1KA6 A;  2HMH A;  3IMD A;  1Z3K A;  1AOT F;  1Y1U A;  2HDV A;  1O4K A;  4XZ0 A;  1JYQ A;  3OP0 A;  1O4C A;  1O4N A;  2FO0 A;  5AUL A;  1CWE A;  4DGX A;  1BM2 A;  2PLE A;  1D4T A;  3CXL A;  4XZ1 A;  1O4F A;  1GHU A;  5I6V A;  2SHP A;  3BUN B;  2K79 B;  4WWQ A;  4GL9 E;  1AB2 A;  2RVF A;  1M27 A;  2HDX A;  1KC2 A;  4JE4 A;  4EY0 A;  4E68 A;  2KNO A;  2PLD A;  3VRN A;  5EHR A;  2DLY A;  1SHB A;  3PQZ A;  3VS0 A;  4M4Z A;  3N8M A;  2DCR A;  2CI9 A;  1CWD L;  2H46 E;  1NZL A;  1SKJ A;  4OHI A;  1O44 A;  3OV1 A;  4FL3 A;  2EL8 A;  1O4G A;  1BLJ A;  1OPL A;  2ROR A;  2CS0 A;  1O4D A;  3UF4 A;  2XP1 A;  4K2R A;  1O4I A;  3VS2 A;  4DGP A;  1NZV A;  3VRQ A;  2IUH A;  3VRP A;  4F59 A;  1I3Z A;  3BUM B;  1AD5 A;  3MXC A;  2LNW A;  4LUD A;  5GJH A;  5HKZ A;  1B47 A;  1O42 A;  1O4J A;  2HUW A;  4FBN A;  3US4 A;  3QWY A;  4GWF A;  2EU0 A;  2KK6 A;  3EAC A;  2DM0 A;  2IUI A;  2EOB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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