2HUWA

X-ray crystal structure of the grb2 sh2 domain complexed to a constrained and cyclopropane-derived ligand
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
101
structure length
101
Chain Sequence
MKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ligand Preorganization May Be Accompanied by Entropic Penalties in Protein-Ligand Interactions.
pubmed doi rcsb
molecule tags Hormone/growth factor
source organism Homo sapiens
molecule keywords Growth factor receptor-bound protein 2
total genus 25
structure length 101
sequence length 101
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-07-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00017 SH2 SH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 2huwA00
1A1AA 1A08A 3VRQA 2FO0A 3PLFB 4F59A 4U17A 2PLEA 3WA4A 1O44A 1A81A 1F2FA 3UF4A 2MRJA 1PICA 3S8OA 2BBUA 2OZOA 1UURA 2IUIA 2L6KA 3MAZA 1O4JA 2DLYA 5EHPA 2XP1A 2EYZA 2H5KA 4LUEA 4GL9E 1ZFPE 2PNBA 5HKZA 2DM0A 1O43A 1TZEE 3S8LA 1O48A 1SPSA 3K2MA 4XZ1A 1LUNA 5DC9A 2LCTA 3IN8A 1CSZA 1BFIA 1BKMA 1AOUF 1O4CA 1KC2A 1O4PA 3VRRA 3S8NA 2EKXA 1FMKA 1FYRA 2CS0A 2KNOA 1X27A 4A4CA 4NWGA 1OPLA 1O45A 2KK6A 3HHMB 5DC0B 1D1ZA 2H8HA 3HIZB 1TCEA 2JYQA 3NHNA 1O4GA 5GJIA 3PSKA 3PQZA 3IN7A 1X0NA 1CWEA 2EO6A 3HCKA 3QWYA 1SPRA 4ROJA 1BFJA 3US4A 5EG3B 4NWFA 2GSBA 1O49A 4F5AA 2RSYA 4JE4A 1BM2A 4M4ZA 1JU5A 2AOBA 5AXIA 1O4AA 2HDXA 4X6SA 2PLDA 1QADA 2CR4A 1O4BA 1O46A 3ZNIA 1R1QA 3CBLA 1XA6A 1YVLA 1Z3KA 3IMJA 3VS5A 4K11A 2ECDA 1LUMA 2EO3A 3VS2A 3GXXA 1AB2A 5D0JA 1O4MA 2MK2A 3OV1A 1IS0A 1SHDA 2SRCA 4U1PA 2EU0A 3PJPA 3T04A 4OHDA 1JYRA 1NRVA 3IMDA 2DX0A 3QWXX 3BUMB 2EYYA 2HUWA 1SKJA 3TL0A 5DF6A 5I6VA 3PFVA 1M27A 1UUSA 2HDVA 4P9ZA 1G83A 1A09A 4D8KA 1MILA 2ETZA 1LCKA 2IUGA 1MW4A 1RPYA 3PS5A 1WQUA 1CJ1A 1A1BA 4WWQA 1FBVA 2EL8A 3TKZA 5HKYA 4EIHA 2Y1NA 3N84A 3N7YA 1CSYA 3KFJA 1R1SA 2PTKA 3BUXB 4E93A 2QMSA 2RORA 1BHFA 2C0IA 2CBLA 1BHHB 1GRIA 1HCTB 1P13A 1O4LA 1NZLA 1CWDL 1R1PA 4OHEA 2IZVA 3VS0A 4A4BA 4K44A 2RMXA 1BLKA 5EELA 1D4WA 3CD3A 1IJRA 2DCRA 1LUIA 2B3OA 1O4HA 3MXYA 1BLJA 1YVHA 4K45A 1O4RA 2SHPA 1O4OA 1FBZA 1O4NA 1A07A 3VS4A 4DGPA 1Y57A 2RVFA 1AYBA 3GXWA 1LUKA 2C0OA 1HCSB 1RQQC 2C0TA 1O42A 1RJAA 1FU5A 2CI8A 1QCFA 3BUNB 3UYOA 1LCJA 4EY0A 2K79B 2K7AB 1AD5A 3VS6A 2C9WA 2CIAA 5EHRA 2FCIA 5AULA 3BKBA 2YU7A 1LKLA 2DVJA 4XZ0A 3C7IA 1LKKA 3VS7A 1O4EA 2DLZA 2L3TA 5EEQA 2H46E 2OQ1A 4FBNA 2MQIA 1O4IA 1F1WA 1D4TA 2LNXA 3OVEA 1AYDA 4FL2A 1AOTF 2VIFA 1QG1E 1O4FA 3VS1A 1K9AA 1O4QA 5BO4A 3OP0A 2HMHA 4QSYA 1KA7A 1GHUA 3PSJA 2PNAA 2HCKA 4OHHA 1BG1A 4H1OA 4F5BA 2CRHA 4L1BB 1O41A 2LQNA 1BF5A 1KSWA 5KAZA 3EACA 1KA6A 2GE9A 3GQIB 1B47A 5DC4A 4FL3A 1H9OA 2EOBA 1A1CA 1OPKA 1AYCA 1JYQA 1I3ZA 3VS3A 5CDWA 3CWGA 3CXLA 3VROA 1BMBA 2AOAA 4DGXA 3BUWB 2YSXA 2AUGA 3N8MA 3S9KA 1A1EA 1JWOA 1O4DA 4K2RA 2LNWA 3VRPA 2CI9A 2LQWA 4OHLA 4GPLB 4P9VA 1BKLA 1SHBA 5IBMA 1M61A 4E68A 1O47A 3MXCA 5IBSA 4JEGA 2EYVA 2IUHA 3BUOB 5HKWA 2Y3AB 1FU6A 1Y1UA 1SHAA 3EAZA 4JGHA 3VGOA 1NZVA 1O4KA 1OO3A 4TZIA 1X6CA 3VRZA 1OO4A 2Y1MA 5J3XA 1BHHA 3OB2B 3M7FA 5GJHA 4LUDA 1JYUA 1FHSA 3VRYA 2MRKA 3OB1B 2L4KA 3VRNA 2MC1A 4OHIA 4H34A 4GWFA 2ABLA 1AYAA
chains in the Genus database with same CATH superfamily
3LYVA 1A1AA 1A08A 3VRQA 2FO0A 3PLFB 4F59A 4U17A 2PLEA 3WA4A 1O44A 1A81A 1F2FA 3UF4A 2MRJA 1PICA 3S8OA 2BBUA 2OZOA 1UURA 2IUIA 2L6KA 3MAZA 1O4JA 2DLYA 5EHPA 2XP1A 2EYZA 2H5KA 4LUEA 4GL9E 1ZFPE 2PNBA 5HKZA 2DM0A 1O43A 1TZEE 3S8LA 1O48A 1SPSA 3K2MA 4XZ1A 1LUNA 5DC9A 2LCTA 3IN8A 1CSZA 1BFIA 1BKMA 1AOUF 1O4CA 1KC2A 1O4PA 3VRRA 3S8NA 2EKXA 1FMKA 1FYRA 2CS0A 2KNOA 1X27A 4A4CA 4NWGA 1OPLA 1O45A 2KK6A 3HHMB 5DC0B 1D1ZA 2H8HA 3HIZB 1TCEA 2JYQA 3NHNA 1O4GA 5GJIA 3PSKA 3PQZA 3IN7A 1X0NA 1CWEA 2EO6A 3HCKA 3QWYA 1SPRA 4ROJA 1BFJA 3US4A 5EG3B 4NWFA 2GSBA 1O49A 4F5AA 2RSYA 4JE4A 1BM2A 4M4ZA 1JU5A 2AOBA 5AXIA 1O4AA 2HDXA 4X6SA 2PLDA 1QADA 2CR4A 1O4BA 1O46A 3ZNIA 1R1QA 3CBLA 1XA6A 1YVLA 1Z3KA 3IMJA 3VS5A 4K11A 2ECDA 1LUMA 2EO3A 3VS2A 3GXXA 1AB2A 5D0JA 1O4MA 2MK2A 3OV1A 1IS0A 1SHDA 2SRCA 4U1PA 2EU0A 3PJPA 3T04A 4OHDA 1JYRA 1NRVA 3IMDA 2DX0A 3QWXX 3BUMB 2EYYA 2HUWA 1SKJA 3TL0A 5DF6A 5I6VA 3PFVA 1M27A 1UUSA 2HDVA 4P9ZA 1G83A 1A09A 4D8KA 1MILA 2ETZA 1LCKA 2IUGA 1MW4A 1RPYA 3PS5A 1WQUA 1CJ1A 1A1BA 4WWQA 1FBVA 2EL8A 3TKZA 5HKYA 4EIHA 2Y1NA 3N84A 3N7YA 1CSYA 3KFJA 2LRAA 1R1SA 2PTKA 3BUXB 4E93A 2QMSA 2RORA 1BHFA 2C0IA 2CBLA 2KGYA 1BHHB 1GRIA 1HCTB 1P13A 1O4LA 1NZLA 1CWDL 1R1PA 4OHEA 2IZVA 3VS0A 4A4BA 4K44A 2RMXA 1BLKA 5EELA 1D4WA 3CD3A 1IJRA 2DCRA 1LUIA 2B3OA 1O4HA 3MXYA 1BLJA 1YVHA 4K45A 1O4RA 2SHPA 1O4OA 1FBZA 1O4NA 1A07A 3VS4A 4DGPA 1Y57A 2RVFA 1AYBA 3GXWA 1LUKA 2C0OA 1HCSB 1RQQC 2C0TA 1O42A 1RJAA 1FU5A 2CI8A 1QCFA 3BUNB 3UYOA 1LCJA 4EY0A 2K79B 2K7AB 1AD5A 3VS6A 2C9WA 2CIAA 5EHRA 2FCIA 5AULA 3BKBA 2YU7A 1LKLA 2DVJA 4XZ0A 3C7IA 1LKKA 3VS7A 1O4EA 2DLZA 2L3TA 5EEQA 2H46E 2OQ1A 4FBNA 2MQIA 1O4IA 1F1WA 1D4TA 2LNXA 3OVEA 1AYDA 4FL2A 1AOTF 2VIFA 1QG1E 1O4FA 3VS1A 1K9AA 1O4QA 5BO4A 3OP0A 2HMHA 4QSYA 1KA7A 1GHUA 3PSJA 2PNAA 2HCKA 4OHHA 1BG1A 4H1OA 4F5BA 2CRHA 4L1BB 1O41A 2LQNA 1BF5A 1KSWA 5KAZA 3EACA 1KA6A 2GE9A 3GQIB 1B47A 5DC4A 4FL3A 1H9OA 2EOBA 1A1CA 1OPKA 1AYCA 1JYQA 1I3ZA 3VS3A 3K2TA 5CDWA 3CWGA 3CXLA 3VROA 1BMBA 2AOAA 4DGXA 3BUWB 2YSXA 2AUGA 3N8MA 3S9KA 1A1EA 1JWOA 1O4DA 4K2RA 2LNWA 3VRPA 2CI9A 2LQWA 4OHLA 4GPLB 4P9VA 1BKLA 1SHBA 5IBMA 1M61A 4E68A 1O47A 3MXCA 5IBSA 4JEGA 2EYVA 2IUHA 3BUOB 5HKWA 2Y3AB 1FU6A 1Y1UA 1SHAA 3EAZA 4JGHA 3VGOA 1NZVA 1O4KA 1OO3A 4TZIA 1X6CA 3VRZA 1OO4A 2Y1MA 5J3XA 1BHHA 3OB2B 3M7FA 5GJHA 4LUDA 1JYUA 1FHSA 3VRYA 2MRKA 3OB1B 2L4KA 3VRNA 2MC1A 4OHIA 4H34A 4GWFA 2ABLA 1AYAA
chains in the Genus database with same CATH topology
1A1AA 1A08A 3VRQA 2FO0A 3PLFB 4F59A 4U17A 2PLEA 3WA4A 1O44A 1A81A 1F2FA 3UF4A 2MRJA 1PICA 3S8OA 2BBUA 2OZOA 1UURA 2IUIA 2L6KA 3MAZA 1O4JA 2DLYA 5EHPA 2XP1A 2EYZA 2H5KA 4LUEA 4GL9E 1ZFPE 2PNBA 5HKZA 2DM0A 1O43A 1TZEE 3S8LA 1O48A 1SPSA 3K2MA 4XZ1A 1LUNA 5DC9A 2LCTA 3IN8A 1CSZA 1BFIA 1BKMA 1AOUF 1O4CA 1KC2A 1O4PA 3VRRA 3S8NA 2EKXA 1FMKA 1FYRA 2CS0A 2KNOA 1X27A 4A4CA 4NWGA 1OPLA 1O45A 2KK6A 3HHMB 5DC0B 1D1ZA 2H8HA 3HIZB 1TCEA 2JYQA 3NHNA 1O4GA 5GJIA 3PSKA 3PQZA 3IN7A 1X0NA 1CWEA 2EO6A 3HCKA 3QWYA 1SPRA 4ROJA 1BFJA 3US4A 5EG3B 4NWFA 2GSBA 1O49A 4F5AA 2RSYA 4JE4A 1BM2A 4M4ZA 1JU5A 2AOBA 5AXIA 1O4AA 2HDXA 4X6SA 2PLDA 1QADA 2CR4A 1O4BA 1O46A 3ZNIA 1R1QA 3CBLA 1XA6A 1YVLA 1Z3KA 3IMJA 3VS5A 4K11A 2ECDA 1LUMA 2EO3A 3VS2A 3GXXA 1AB2A 5D0JA 1O4MA 2MK2A 3OV1A 1IS0A 1SHDA 2SRCA 4U1PA 2EU0A 3PJPA 3T04A 4OHDA 1JYRA 1NRVA 3IMDA 2DX0A 3QWXX 3BUMB 2EYYA 2HUWA 1SKJA 3TL0A 5DF6A 5I6VA 3PFVA 1M27A 1UUSA 2HDVA 4P9ZA 1G83A 1A09A 4D8KA 1MILA 2ETZA 1LCKA 2IUGA 1MW4A 1RPYA 3PS5A 1WQUA 1CJ1A 1A1BA 4WWQA 1FBVA 2EL8A 3TKZA 5HKYA 4EIHA 2Y1NA 3N84A 3N7YA 1CSYA 3KFJA 1R1SA 2PTKA 3BUXB 4E93A 2QMSA 2RORA 1BHFA 2C0IA 2CBLA 1BHHB 1GRIA 1HCTB 1P13A 1O4LA 1NZLA 1CWDL 1R1PA 4OHEA 2IZVA 3VS0A 4A4BA 4K44A 2RMXA 1BLKA 5EELA 1D4WA 3CD3A 1IJRA 2DCRA 1LUIA 2B3OA 1O4HA 3MXYA 1BLJA 1YVHA 4K45A 1O4RA 2SHPA 1O4OA 1FBZA 1O4NA 1A07A 3VS4A 4DGPA 1Y57A 2RVFA 1AYBA 3GXWA 1LUKA 2C0OA 1HCSB 1RQQC 2C0TA 1O42A 1RJAA 1FU5A 2CI8A 1QCFA 3BUNB 3UYOA 1LCJA 4EY0A 2K79B 2K7AB 1AD5A 3VS6A 2C9WA 2CIAA 5EHRA 2FCIA 5AULA 3BKBA 2YU7A 1LKLA 2DVJA 4XZ0A 3C7IA 1LKKA 3VS7A 1O4EA 2DLZA 2L3TA 5EEQA 2H46E 2OQ1A 4FBNA 2MQIA 1O4IA 1F1WA 1D4TA 2LNXA 3OVEA 1AYDA 4FL2A 1AOTF 2VIFA 1QG1E 1O4FA 3VS1A 1K9AA 1O4QA 5BO4A 3OP0A 2HMHA 4QSYA 1KA7A 1GHUA 3PSJA 2PNAA 2HCKA 4OHHA 1BG1A 4H1OA 4F5BA 2CRHA 4L1BB 1O41A 2LQNA 1BF5A 1KSWA 5KAZA 3EACA 1KA6A 2GE9A 3GQIB 1B47A 5DC4A 4FL3A 1H9OA 2EOBA 1A1CA 1OPKA 1AYCA 1JYQA 1I3ZA 3VS3A 5CDWA 3CWGA 3CXLA 3VROA 1BMBA 2AOAA 4DGXA 3BUWB 2YSXA 2AUGA 3N8MA 3S9KA 1A1EA 1JWOA 1O4DA 4K2RA 2LNWA 3VRPA 2CI9A 2LQWA 4OHLA 4GPLB 4P9VA 1BKLA 1SHBA 5IBMA 1M61A 4E68A 1O47A 3MXCA 5IBSA 4JEGA 2EYVA 2IUHA 3BUOB 5HKWA 2Y3AB 1FU6A 1Y1UA 1SHAA 3EAZA 4JGHA 3VGOA 1NZVA 1O4KA 1OO3A 4TZIA 1X6CA 3VRZA 1OO4A 2Y1MA 5J3XA 1BHHA 3OB2B 3M7FA 5GJHA 4LUDA 1JYUA 1FHSA 3VRYA 2MRKA 3OB1B 2L4KA 3VRNA 2MC1A 4OHIA 4H34A 4GWFA 2ABLA 1AYAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1A1A A;  1A08 A;  3VRQ A;  2FO0 A;  3PLF B;  4F59 A;  4U17 A;  2PLE A;  3WA4 A;  1O44 A;  1A81 A;  1F2F A;  3UF4 A;  2MRJ A;  1PIC A;  3S8O A;  2BBU A;  2OZO A;  1UUR A;  2IUI A;  2L6K A;  3MAZ A;  1O4J A;  2DLY A;  5EHP A;  2XP1 A;  2EYZ A;  2H5K A;  4LUE A;  4GL9 E;  1ZFP E;  2PNB A;  5HKZ A;  2DM0 A;  1O43 A;  1TZE E;  3S8L A;  1O48 A;  1SPS A;  3K2M A;  4XZ1 A;  1LUN A;  5DC9 A;  2LCT A;  3IN8 A;  1CSZ A;  1BFI A;  1BKM A;  1AOU F;  1O4C A;  1KC2 A;  1O4P A;  3VRR A;  3S8N A;  2EKX A;  1FMK A;  1FYR A;  2CS0 A;  2KNO A;  1X27 A;  4A4C A;  4NWG A;  1OPL A;  1O45 A;  2KK6 A;  3HHM B;  5DC0 B;  1D1Z A;  2H8H A;  3HIZ B;  1TCE A;  2JYQ A;  3NHN A;  1O4G A;  5GJI A;  3PSK A;  3PQZ A;  3IN7 A;  1X0N A;  1CWE A;  2EO6 A;  3HCK A;  3QWY A;  1SPR A;  4ROJ A;  1BFJ A;  3US4 A;  5EG3 B;  4NWF A;  2GSB A;  1O49 A;  4F5A A;  2RSY A;  4JE4 A;  1BM2 A;  4M4Z A;  1JU5 A;  2AOB A;  5AXI A;  1O4A A;  2HDX A;  4X6S A;  2PLD A;  1QAD A;  2CR4 A;  1O4B A;  1O46 A;  3ZNI A;  1R1Q A;  3CBL A;  1XA6 A;  1YVL A;  1Z3K A;  3IMJ A;  3VS5 A;  4K11 A;  2ECD A;  1LUM A;  2EO3 A;  3VS2 A;  3GXX A;  1AB2 A;  5D0J A;  1O4M A;  2MK2 A;  3OV1 A;  1IS0 A;  1SHD A;  2SRC A;  4U1P A;  2EU0 A;  3PJP A;  3T04 A;  4OHD A;  1JYR A;  1NRV A;  3IMD A;  2DX0 A;  3QWX X;  3BUM B;  2EYY A;  2HUW A;  1SKJ A;  3TL0 A;  5DF6 A;  5I6V A;  3PFV A;  1M27 A;  1UUS A;  2HDV A;  4P9Z A;  1G83 A;  1A09 A;  4D8K A;  1MIL A;  2ETZ A;  1LCK A;  2IUG A;  1MW4 A;  1RPY A;  3PS5 A;  1WQU A;  1CJ1 A;  1A1B A;  4WWQ A;  1FBV A;  2EL8 A;  3TKZ A;  5HKY A;  4EIH A;  2Y1N A;  3N84 A;  3N7Y A;  1CSY A;  3KFJ A;  1R1S A;  2PTK A;  3BUX B;  4E93 A;  2QMS A;  2ROR A;  1BHF A;  2C0I A;  2CBL A;  1BHH B;  1GRI A;  1HCT B;  1P13 A;  1O4L A;  1NZL A;  1CWD L;  1R1P A;  4OHE A;  2IZV A;  3VS0 A;  4A4B A;  4K44 A;  2RMX A;  1BLK A;  5EEL A;  1D4W A;  3CD3 A;  1IJR A;  2DCR A;  1LUI A;  2B3O A;  1O4H A;  3MXY A;  1BLJ A;  1YVH A;  4K45 A;  1O4R A;  2SHP A;  1O4O A;  1FBZ A;  1O4N A;  1A07 A;  3VS4 A;  4DGP A;  1Y57 A;  2RVF A;  1AYB A;  3GXW A;  1LUK A;  2C0O A;  1HCS B;  1RQQ C;  2C0T A;  1O42 A;  1RJA A;  1FU5 A;  2CI8 A;  1QCF A;  3BUN B;  3UYO A;  1LCJ A;  4EY0 A;  2K79 B;  2K7A B;  1AD5 A;  3VS6 A;  2C9W A;  2CIA A;  5EHR A;  2FCI A;  5AUL A;  3BKB A;  2YU7 A;  1LKL A;  2DVJ A;  4XZ0 A;  3C7I A;  1LKK A;  3VS7 A;  1O4E A;  2DLZ A;  2L3T A;  5EEQ A;  2H46 E;  2OQ1 A;  4FBN A;  2MQI A;  1O4I A;  1F1W A;  1D4T A;  2LNX A;  3OVE A;  1AYD A;  4FL2 A;  1AOT F;  2VIF A;  1QG1 E;  1O4F A;  3VS1 A;  1K9A A;  1O4Q A;  5BO4 A;  3OP0 A;  2HMH A;  4QSY A;  1KA7 A;  1GHU A;  3PSJ A;  2PNA A;  2HCK A;  4OHH A;  1BG1 A;  4H1O A;  4F5B A;  2CRH A;  4L1B B;  1O41 A;  2LQN A;  1BF5 A;  1KSW A;  5KAZ A;  3EAC A;  1KA6 A;  2GE9 A;  3GQI B;  1B47 A;  5DC4 A;  4FL3 A;  1H9O A;  2EOB A;  1A1C A;  1OPK A;  1AYC A;  1JYQ A;  1I3Z A;  3VS3 A;  5CDW A;  3CWG A;  3CXL A;  3VRO A;  1BMB A;  2AOA A;  4DGX A;  3BUW B;  2YSX A;  2AUG A;  3N8M A;  3S9K A;  1A1E A;  1JWO A;  1O4D A;  4K2R A;  2LNW A;  3VRP A;  2CI9 A;  2LQW A;  4OHL A;  4GPL B;  4P9V A;  1BKL A;  1SHB A;  5IBM A;  1M61 A;  4E68 A;  1O47 A;  3MXC A;  5IBS A;  4JEG A;  2EYV A;  2IUH A;  3BUO B;  5HKW A;  2Y3A B;  1FU6 A;  1Y1U A;  1SHA A;  3EAZ A;  4JGH A;  3VGO A;  1NZV A;  1O4K A;  1OO3 A;  4TZI A;  1X6C A;  3VRZ A;  1OO4 A;  2Y1M A;  5J3X A;  1BHH A;  3OB2 B;  3M7F A;  5GJH A;  4LUD A;  1JYU A;  1FHS A;  3VRY A;  2MRK A;  3OB1 B;  2L4K A;  3VRN A;  2MC1 A;  4OHI A;  4H34 A;  4GWF A;  2ABL A;  1AYA A; 
#chains in the Genus database with same CATH topology
 3LYV A;  1A1A A;  1A08 A;  3VRQ A;  2FO0 A;  3PLF B;  4F59 A;  4U17 A;  2PLE A;  3WA4 A;  1O44 A;  1A81 A;  1F2F A;  3UF4 A;  2MRJ A;  1PIC A;  3S8O A;  2BBU A;  2OZO A;  1UUR A;  2IUI A;  2L6K A;  3MAZ A;  1O4J A;  2DLY A;  5EHP A;  2XP1 A;  2EYZ A;  2H5K A;  4LUE A;  4GL9 E;  1ZFP E;  2PNB A;  5HKZ A;  2DM0 A;  1O43 A;  1TZE E;  3S8L A;  1O48 A;  1SPS A;  3K2M A;  4XZ1 A;  1LUN A;  5DC9 A;  2LCT A;  3IN8 A;  1CSZ A;  1BFI A;  1BKM A;  1AOU F;  1O4C A;  1KC2 A;  1O4P A;  3VRR A;  3S8N A;  2EKX A;  1FMK A;  1FYR A;  2CS0 A;  2KNO A;  1X27 A;  4A4C A;  4NWG A;  1OPL A;  1O45 A;  2KK6 A;  3HHM B;  5DC0 B;  1D1Z A;  2H8H A;  3HIZ B;  1TCE A;  2JYQ A;  3NHN A;  1O4G A;  5GJI A;  3PSK A;  3PQZ A;  3IN7 A;  1X0N A;  1CWE A;  2EO6 A;  3HCK A;  3QWY A;  1SPR A;  4ROJ A;  1BFJ A;  3US4 A;  5EG3 B;  4NWF A;  2GSB A;  1O49 A;  4F5A A;  2RSY A;  4JE4 A;  1BM2 A;  4M4Z A;  1JU5 A;  2AOB A;  5AXI A;  1O4A A;  2HDX A;  4X6S A;  2PLD A;  1QAD A;  2CR4 A;  1O4B A;  1O46 A;  3ZNI A;  1R1Q A;  3CBL A;  1XA6 A;  1YVL A;  1Z3K A;  3IMJ A;  3VS5 A;  4K11 A;  2ECD A;  1LUM A;  2EO3 A;  3VS2 A;  3GXX A;  1AB2 A;  5D0J A;  1O4M A;  2MK2 A;  3OV1 A;  1IS0 A;  1SHD A;  2SRC A;  4U1P A;  2EU0 A;  3PJP A;  3T04 A;  4OHD A;  1JYR A;  1NRV A;  3IMD A;  2DX0 A;  3QWX X;  3BUM B;  2EYY A;  2HUW A;  1SKJ A;  3TL0 A;  5DF6 A;  5I6V A;  3PFV A;  1M27 A;  1UUS A;  2HDV A;  4P9Z A;  1G83 A;  1A09 A;  4D8K A;  1MIL A;  2ETZ A;  1LCK A;  2IUG A;  1MW4 A;  1RPY A;  3PS5 A;  1WQU A;  1CJ1 A;  1A1B A;  4WWQ A;  1FBV A;  2EL8 A;  3TKZ A;  5HKY A;  4EIH A;  2Y1N A;  3N84 A;  3N7Y A;  1CSY A;  3KFJ A;  2LRA A;  1R1S A;  2PTK A;  3BUX B;  4E93 A;  2QMS A;  2ROR A;  1BHF A;  2C0I A;  2CBL A;  2KGY A;  1BHH B;  1GRI A;  1HCT B;  1P13 A;  1O4L A;  1NZL A;  1CWD L;  1R1P A;  4OHE A;  2IZV A;  3VS0 A;  4A4B A;  4K44 A;  2RMX A;  1BLK A;  5EEL A;  1D4W A;  3CD3 A;  1IJR A;  2DCR A;  1LUI A;  2B3O A;  1O4H A;  3MXY A;  1BLJ A;  1YVH A;  4K45 A;  1O4R A;  2SHP A;  1O4O A;  1FBZ A;  1O4N A;  1A07 A;  3VS4 A;  4DGP A;  1Y57 A;  2RVF A;  1AYB A;  3GXW A;  1LUK A;  2C0O A;  1HCS B;  1RQQ C;  2C0T A;  1O42 A;  1RJA A;  1FU5 A;  2CI8 A;  1QCF A;  3BUN B;  3UYO A;  1LCJ A;  4EY0 A;  2K79 B;  2K7A B;  1AD5 A;  3VS6 A;  2C9W A;  2CIA A;  5EHR A;  2FCI A;  5AUL A;  3BKB A;  2YU7 A;  1LKL A;  2DVJ A;  4XZ0 A;  3C7I A;  1LKK A;  3VS7 A;  1O4E A;  2DLZ A;  2L3T A;  5EEQ A;  2H46 E;  2OQ1 A;  4FBN A;  2MQI A;  1O4I A;  1F1W A;  1D4T A;  2LNX A;  3OVE A;  1AYD A;  4FL2 A;  1AOT F;  2VIF A;  1QG1 E;  1O4F A;  3VS1 A;  1K9A A;  1O4Q A;  5BO4 A;  3OP0 A;  2HMH A;  4QSY A;  1KA7 A;  1GHU A;  3PSJ A;  2PNA A;  2HCK A;  4OHH A;  1BG1 A;  4H1O A;  4F5B A;  2CRH A;  4L1B B;  1O41 A;  2LQN A;  1BF5 A;  1KSW A;  5KAZ A;  3EAC A;  1KA6 A;  2GE9 A;  3GQI B;  1B47 A;  5DC4 A;  4FL3 A;  1H9O A;  2EOB A;  1A1C A;  1OPK A;  1AYC A;  1JYQ A;  1I3Z A;  3VS3 A;  3K2T A;  5CDW A;  3CWG A;  3CXL A;  3VRO A;  1BMB A;  2AOA A;  4DGX A;  3BUW B;  2YSX A;  2AUG A;  3N8M A;  3S9K A;  1A1E A;  1JWO A;  1O4D A;  4K2R A;  2LNW A;  3VRP A;  2CI9 A;  2LQW A;  4OHL A;  4GPL B;  4P9V A;  1BKL A;  1SHB A;  5IBM A;  1M61 A;  4E68 A;  1O47 A;  3MXC A;  5IBS A;  4JEG A;  2EYV A;  2IUH A;  3BUO B;  5HKW A;  2Y3A B;  1FU6 A;  1Y1U A;  1SHA A;  3EAZ A;  4JGH A;  3VGO A;  1NZV A;  1O4K A;  1OO3 A;  4TZI A;  1X6C A;  3VRZ A;  1OO4 A;  2Y1M A;  5J3X A;  1BHH A;  3OB2 B;  3M7F A;  5GJH A;  4LUD A;  1JYU A;  1FHS A;  3VRY A;  2MRK A;  3OB1 B;  2L4K A;  3VRN A;  2MC1 A;  4OHI A;  4H34 A;  4GWF A;  2ABL A;  1AYA A; 
#chains in the Genus database with same CATH homology
 1A1A A;  1A08 A;  3VRQ A;  2FO0 A;  3PLF B;  4F59 A;  4U17 A;  2PLE A;  3WA4 A;  1O44 A;  1A81 A;  1F2F A;  3UF4 A;  2MRJ A;  1PIC A;  3S8O A;  2BBU A;  2OZO A;  1UUR A;  2IUI A;  2L6K A;  3MAZ A;  1O4J A;  2DLY A;  5EHP A;  2XP1 A;  2EYZ A;  2H5K A;  4LUE A;  4GL9 E;  1ZFP E;  2PNB A;  5HKZ A;  2DM0 A;  1O43 A;  1TZE E;  3S8L A;  1O48 A;  1SPS A;  3K2M A;  4XZ1 A;  1LUN A;  5DC9 A;  2LCT A;  3IN8 A;  1CSZ A;  1BFI A;  1BKM A;  1AOU F;  1O4C A;  1KC2 A;  1O4P A;  3VRR A;  3S8N A;  2EKX A;  1FMK A;  1FYR A;  2CS0 A;  2KNO A;  1X27 A;  4A4C A;  4NWG A;  1OPL A;  1O45 A;  2KK6 A;  3HHM B;  5DC0 B;  1D1Z A;  2H8H A;  3HIZ B;  1TCE A;  2JYQ A;  3NHN A;  1O4G A;  5GJI A;  3PSK A;  3PQZ A;  3IN7 A;  1X0N A;  1CWE A;  2EO6 A;  3HCK A;  3QWY A;  1SPR A;  4ROJ A;  1BFJ A;  3US4 A;  5EG3 B;  4NWF A;  2GSB A;  1O49 A;  4F5A A;  2RSY A;  4JE4 A;  1BM2 A;  4M4Z A;  1JU5 A;  2AOB A;  5AXI A;  1O4A A;  2HDX A;  4X6S A;  2PLD A;  1QAD A;  2CR4 A;  1O4B A;  1O46 A;  3ZNI A;  1R1Q A;  3CBL A;  1XA6 A;  1YVL A;  1Z3K A;  3IMJ A;  3VS5 A;  4K11 A;  2ECD A;  1LUM A;  2EO3 A;  3VS2 A;  3GXX A;  1AB2 A;  5D0J A;  1O4M A;  2MK2 A;  3OV1 A;  1IS0 A;  1SHD A;  2SRC A;  4U1P A;  2EU0 A;  3PJP A;  3T04 A;  4OHD A;  1JYR A;  1NRV A;  3IMD A;  2DX0 A;  3QWX X;  3BUM B;  2EYY A;  2HUW A;  1SKJ A;  3TL0 A;  5DF6 A;  5I6V A;  3PFV A;  1M27 A;  1UUS A;  2HDV A;  4P9Z A;  1G83 A;  1A09 A;  4D8K A;  1MIL A;  2ETZ A;  1LCK A;  2IUG A;  1MW4 A;  1RPY A;  3PS5 A;  1WQU A;  1CJ1 A;  1A1B A;  4WWQ A;  1FBV A;  2EL8 A;  3TKZ A;  5HKY A;  4EIH A;  2Y1N A;  3N84 A;  3N7Y A;  1CSY A;  3KFJ A;  1R1S A;  2PTK A;  3BUX B;  4E93 A;  2QMS A;  2ROR A;  1BHF A;  2C0I A;  2CBL A;  1BHH B;  1GRI A;  1HCT B;  1P13 A;  1O4L A;  1NZL A;  1CWD L;  1R1P A;  4OHE A;  2IZV A;  3VS0 A;  4A4B A;  4K44 A;  2RMX A;  1BLK A;  5EEL A;  1D4W A;  3CD3 A;  1IJR A;  2DCR A;  1LUI A;  2B3O A;  1O4H A;  3MXY A;  1BLJ A;  1YVH A;  4K45 A;  1O4R A;  2SHP A;  1O4O A;  1FBZ A;  1O4N A;  1A07 A;  3VS4 A;  4DGP A;  1Y57 A;  2RVF A;  1AYB A;  3GXW A;  1LUK A;  2C0O A;  1HCS B;  1RQQ C;  2C0T A;  1O42 A;  1RJA A;  1FU5 A;  2CI8 A;  1QCF A;  3BUN B;  3UYO A;  1LCJ A;  4EY0 A;  2K79 B;  2K7A B;  1AD5 A;  3VS6 A;  2C9W A;  2CIA A;  5EHR A;  2FCI A;  5AUL A;  3BKB A;  2YU7 A;  1LKL A;  2DVJ A;  4XZ0 A;  3C7I A;  1LKK A;  3VS7 A;  1O4E A;  2DLZ A;  2L3T A;  5EEQ A;  2H46 E;  2OQ1 A;  4FBN A;  2MQI A;  1O4I A;  1F1W A;  1D4T A;  2LNX A;  3OVE A;  1AYD A;  4FL2 A;  1AOT F;  2VIF A;  1QG1 E;  1O4F A;  3VS1 A;  1K9A A;  1O4Q A;  5BO4 A;  3OP0 A;  2HMH A;  4QSY A;  1KA7 A;  1GHU A;  3PSJ A;  2PNA A;  2HCK A;  4OHH A;  1BG1 A;  4H1O A;  4F5B A;  2CRH A;  4L1B B;  1O41 A;  2LQN A;  1BF5 A;  1KSW A;  5KAZ A;  3EAC A;  1KA6 A;  2GE9 A;  3GQI B;  1B47 A;  5DC4 A;  4FL3 A;  1H9O A;  2EOB A;  1A1C A;  1OPK A;  1AYC A;  1JYQ A;  1I3Z A;  3VS3 A;  5CDW A;  3CWG A;  3CXL A;  3VRO A;  1BMB A;  2AOA A;  4DGX A;  3BUW B;  2YSX A;  2AUG A;  3N8M A;  3S9K A;  1A1E A;  1JWO A;  1O4D A;  4K2R A;  2LNW A;  3VRP A;  2CI9 A;  2LQW A;  4OHL A;  4GPL B;  4P9V A;  1BKL A;  1SHB A;  5IBM A;  1M61 A;  4E68 A;  1O47 A;  3MXC A;  5IBS A;  4JEG A;  2EYV A;  2IUH A;  3BUO B;  5HKW A;  2Y3A B;  1FU6 A;  1Y1U A;  1SHA A;  3EAZ A;  4JGH A;  3VGO A;  1NZV A;  1O4K A;  1OO3 A;  4TZI A;  1X6C A;  3VRZ A;  1OO4 A;  2Y1M A;  5J3X A;  1BHH A;  3OB2 B;  3M7F A;  5GJH A;  4LUD A;  1JYU A;  1FHS A;  3VRY A;  2MRK A;  3OB1 B;  2L4K A;  3VRN A;  2MC1 A;  4OHI A;  4H34 A;  4GWF A;  2ABL A;  1AYA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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