2AOAA

Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the grb2 sh2 domain
Total Genus 19
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
19
sequence length
93
structure length
93
Chain Sequence
HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of a High-affinity Macrocyclic Peptide Mimetic in Complex with the Grb2 SH2 Domain.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Growth factor receptor-bound protein 2
total genus 19
structure length 93
sequence length 93
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-08-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00017 SH2 SH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 2aoaA00
2L4KA 3N7YA 5GJHA 1F2FA 2XP1A 2Y1NA 1WQUA 4F59A 3HHMB 3PFVA 3VRRA 3CBLA 5AXIA 2CBLA 1KA6A 3MXYA 2FO0A 5DC9A 1HCSB 5KAZA 2C0IA 2HUWA 1CWEA 1FU5A 1BFJA 4EY0A 1O4DA 3VS6A 2RVFA 1O4QA 1AYDA 2H8HA 2KK6A 2EYVA 1Z3KA 1A81A 1GHUA 1O4NA 5DF6A 2OZOA 2KNOA 3T04A 1A07A 2IUHA 1O4EA 2MRKA 4E68A 2LQNA 2RMXA 4OHIA 2GE9A 1NZLA 3PS5A 1LUIA 3HCKA 1O4IA 1SPSA 3OB2B 2K7AB 3WA4A 2SHPA 1KA7A 4GWFA 1IJRA 1BHHB 4TZIA 1O4AA 5D0JA 1O4PA 2K79B 1BHHA 1SHBA 4NWFA 4X6SA 2EO6A 4JGHA 3VS5A 1BF5A 1SHAA 2C9WA 4OHEA 1UUSA 3GXWA 1BLJA 3IN7A 3VRNA 3PJPA 2L6KA 3MAZA 2IZVA 2QMSA 2CIAA 1M61A 1A08A 1AYAA 3M7FA 3PSKA 1OO4A 1AOTF 3BUMB 1O46A 3UF4A 1A09A 1MILA 3HIZB 2SRCA 1NRVA 2GSBA 2VIFA 2AOBA 4P9VA 1NZVA 1AYCA 3C7IA 3KFJA 4QSYA 3QWXX 3OB1B 2ECDA 2ETZA 1OO3A 1RPYA 2H5KA 3VS3A 2L3TA 2DM0A 1O4FA 1FYRA 2EL8A 5EHPA 4FL2A 4FBNA 1G83A 2PLEA 3TL0A 3ZNIA 5HKWA 1GRIA 2CR4A 1A1BA 1O4CA 1BFIA 2IUGA 3OP0A 1LCJA 1O4HA 2CRHA 1D1ZA 1P13A 4OHDA 2HDVA 4K44A 2EOBA 4JE4A 2DVJA 1D4TA 1O49A 3VS2A 5DC4A 4K2RA 1PICA 3CD3A 2OQ1A 3OVEA 4ROJA 5J3XA 4H1OA 3S8NA 1Y1UA 4E93A 3K2MA 1X27A 1LUMA 1BG1A 3VRZA 1R1SA 3BUXB 3VRYA 4K45A 3CXLA 1KSWA 3OV1A 1D4WA 3VROA 3VS7A 4M4ZA 1IS0A 2LCTA 1O4OA 4F5AA 1QADA 5HKZA 1OPKA 4JEGA 1O44A 1AOUF 1JYRA 5EELA 1A1AA 2YSXA 2PLDA 2DX0A 4OHHA 5HKYA 2PNAA 5BO4A 5EG3B 1O4RA 1CJ1A 2H46E 3VGOA 4WWQA 2DCRA 4DGXA 2MC1A 1CWDL 2EO3A 3S8OA 2HMHA 2AUGA 3VRPA 3PLFB 4OHLA 4EIHA 2JYQA 4XZ1A 2HCKA 1X6CA 2EYYA 1BMBA 3S8LA 1LUKA 1H9OA 4K11A 1O4GA 1SPRA 1CSZA 1F1WA 2DLYA 1O4LA 1O42A 4U17A 1A1CA 1R1QA 1O4BA 1TCEA 1HCTB 4U1PA 2EYZA 2MK2A 1LUNA 1O4KA 3EAZA 2CI8A 2LNWA 4LUEA 1B47A 2PNBA 3PQZA 3S9KA 2LNXA 4L1BB 4F5BA 1JYUA 1XA6A 1FHSA 1X0NA 3IMDA 2PTKA 3VS0A 1O4MA 2RSYA 5CDWA 2EKXA 2C0TA 3IN8A 3BUOB 1FBZA 1O47A 1LCKA 3N84A 1JWOA 2HDXA 5EHRA 1R1PA 1O45A 1ZFPE 2MRJA 3GQIB 1BM2A 1BLKA 2C0OA 1O4JA 1BKLA 3IMJA 3BKBA 4A4BA 5I6VA 1Y57A 1CSYA 4FL3A 2Y3AB 3EACA 3TKZA 2LQWA 4A4CA 1O48A 2YU7A 4XZ0A 1AD5A 1KC2A 1JU5A 1LKLA 1SKJA 5AULA 5GJIA 5IBMA 1OPLA 1YVHA 2FCIA 3MXCA 2AOAA 2EU0A 1A1EA 4LUDA 2Y1MA 1AYBA 1SHDA 2CI9A 3US4A 4D8KA 5EEQA 1UURA 3NHNA 1JYQA 1BKMA 3N8MA 2BBUA 1QG1E 4GL9E 3QWYA 2RORA 4H34A 1O43A 2ABLA 1RJAA 1K9AA 1YVLA 4GPLB 2CS0A 1I3ZA 3BUWB 4DGPA 1FBVA 5IBSA 1TZEE 1FU6A 1O41A 1QCFA 3GXXA 3BUNB 1FMKA 3VS1A 1LKKA 2DLZA 4P9ZA 3UYOA 1BHFA 5DC0B 4NWGA 3VRQA 2IUIA 1M27A 1MW4A 1AB2A 1RQQC 2MQIA 3CWGA 2B3OA 3PSJA 3VS4A
chains in the Genus database with same CATH superfamily
2L4KA 3N7YA 5GJHA 1F2FA 2XP1A 2Y1NA 1WQUA 4F59A 3HHMB 3PFVA 3VRRA 3CBLA 5AXIA 2CBLA 1KA6A 3MXYA 2FO0A 5DC9A 1HCSB 5KAZA 2C0IA 2HUWA 1CWEA 1FU5A 1BFJA 4EY0A 1O4DA 3VS6A 2RVFA 1O4QA 1AYDA 2H8HA 2KK6A 2EYVA 1Z3KA 1A81A 1GHUA 1O4NA 5DF6A 2OZOA 2KNOA 3T04A 1A07A 2IUHA 1O4EA 2MRKA 4E68A 2LQNA 2RMXA 4OHIA 2GE9A 1NZLA 3PS5A 1LUIA 3HCKA 1O4IA 1SPSA 3OB2B 2K7AB 3WA4A 2SHPA 1KA7A 4GWFA 1IJRA 1BHHB 4TZIA 1O4AA 5D0JA 1O4PA 2K79B 1BHHA 1SHBA 4NWFA 4X6SA 2EO6A 4JGHA 3VS5A 1BF5A 3K2TA 1SHAA 2C9WA 4OHEA 1UUSA 3GXWA 1BLJA 3IN7A 3VRNA 3PJPA 2L6KA 3MAZA 2IZVA 2QMSA 2CIAA 1M61A 1A08A 1AYAA 3M7FA 3PSKA 1OO4A 1AOTF 3BUMB 1O46A 3UF4A 1A09A 1MILA 3HIZB 2SRCA 1NRVA 2GSBA 2VIFA 2AOBA 4P9VA 1NZVA 1AYCA 3C7IA 3KFJA 4QSYA 3QWXX 3OB1B 2ECDA 2ETZA 1OO3A 1RPYA 2H5KA 3VS3A 3LYVA 2KGYA 2L3TA 2DM0A 1O4FA 1FYRA 2EL8A 5EHPA 4FL2A 4FBNA 1G83A 2PLEA 3TL0A 3ZNIA 5HKWA 1GRIA 2CR4A 1A1BA 1O4CA 1BFIA 2IUGA 3OP0A 1LCJA 1O4HA 2CRHA 1D1ZA 1P13A 4OHDA 2HDVA 4K44A 2EOBA 4JE4A 2DVJA 1D4TA 1O49A 3VS2A 5DC4A 4K2RA 1PICA 3CD3A 2OQ1A 3OVEA 4ROJA 5J3XA 4H1OA 3S8NA 1Y1UA 4E93A 3K2MA 1X27A 1LUMA 1BG1A 3VRZA 1R1SA 3BUXB 3VRYA 4K45A 3CXLA 1KSWA 3OV1A 1D4WA 3VROA 3VS7A 4M4ZA 1IS0A 2LCTA 1O4OA 4F5AA 1QADA 5HKZA 1OPKA 4JEGA 1O44A 1AOUF 1JYRA 5EELA 1A1AA 2YSXA 2PLDA 2DX0A 4OHHA 5HKYA 2PNAA 5BO4A 5EG3B 1O4RA 1CJ1A 2H46E 3VGOA 4WWQA 2DCRA 4DGXA 2MC1A 1CWDL 2EO3A 3S8OA 2HMHA 2AUGA 3VRPA 3PLFB 4OHLA 4EIHA 2JYQA 4XZ1A 2HCKA 1X6CA 2EYYA 1BMBA 3S8LA 1LUKA 1H9OA 4K11A 1O4GA 1SPRA 1CSZA 1F1WA 2DLYA 1O4LA 1O42A 4U17A 1A1CA 1R1QA 1O4BA 1TCEA 1HCTB 4U1PA 2EYZA 2MK2A 1LUNA 1O4KA 3EAZA 2CI8A 2LNWA 4LUEA 1B47A 2PNBA 3PQZA 3S9KA 2LNXA 4L1BB 4F5BA 1JYUA 1XA6A 1FHSA 1X0NA 3IMDA 2PTKA 3VS0A 1O4MA 2RSYA 5CDWA 2EKXA 2C0TA 3IN8A 3BUOB 1FBZA 1O47A 1LCKA 3N84A 1JWOA 2HDXA 5EHRA 1R1PA 1O45A 1ZFPE 2MRJA 3GQIB 1BM2A 1BLKA 2C0OA 1O4JA 1BKLA 3IMJA 3BKBA 4A4BA 5I6VA 1Y57A 1CSYA 4FL3A 2Y3AB 3EACA 3TKZA 2LRAA 2LQWA 4A4CA 1O48A 2YU7A 4XZ0A 1AD5A 1KC2A 1JU5A 1LKLA 1SKJA 5AULA 5GJIA 5IBMA 1OPLA 1YVHA 2FCIA 3MXCA 2AOAA 2EU0A 1A1EA 4LUDA 2Y1MA 1AYBA 1SHDA 2CI9A 3US4A 4D8KA 5EEQA 1UURA 3NHNA 1JYQA 1BKMA 3N8MA 2BBUA 1QG1E 4GL9E 3QWYA 2RORA 4H34A 1O43A 2ABLA 1RJAA 1K9AA 1YVLA 4GPLB 2CS0A 1I3ZA 3BUWB 4DGPA 1FBVA 5IBSA 1TZEE 1FU6A 1O41A 1QCFA 3GXXA 3BUNB 1FMKA 3VS1A 1LKKA 2DLZA 4P9ZA 3UYOA 1BHFA 5DC0B 4NWGA 3VRQA 2IUIA 1M27A 1MW4A 1AB2A 1RQQC 2MQIA 3CWGA 2B3OA 3PSJA 3VS4A
chains in the Genus database with same CATH topology
2L4KA 3N7YA 5GJHA 1F2FA 2XP1A 2Y1NA 1WQUA 4F59A 3HHMB 3PFVA 3VRRA 3CBLA 5AXIA 2CBLA 1KA6A 3MXYA 2FO0A 5DC9A 1HCSB 5KAZA 2C0IA 2HUWA 1CWEA 1FU5A 1BFJA 4EY0A 1O4DA 3VS6A 2RVFA 1O4QA 1AYDA 2H8HA 2KK6A 2EYVA 1Z3KA 1A81A 1GHUA 1O4NA 5DF6A 2OZOA 2KNOA 3T04A 1A07A 2IUHA 1O4EA 2MRKA 4E68A 2LQNA 2RMXA 4OHIA 2GE9A 1NZLA 3PS5A 1LUIA 3HCKA 1O4IA 1SPSA 3OB2B 2K7AB 3WA4A 2SHPA 1KA7A 4GWFA 1IJRA 1BHHB 4TZIA 1O4AA 5D0JA 1O4PA 2K79B 1BHHA 1SHBA 4NWFA 4X6SA 2EO6A 4JGHA 3VS5A 1BF5A 1SHAA 2C9WA 4OHEA 1UUSA 3GXWA 1BLJA 3IN7A 3VRNA 3PJPA 2L6KA 3MAZA 2IZVA 2QMSA 2CIAA 1M61A 1A08A 1AYAA 3M7FA 3PSKA 1OO4A 1AOTF 3BUMB 1O46A 3UF4A 1A09A 1MILA 3HIZB 2SRCA 1NRVA 2GSBA 2VIFA 2AOBA 4P9VA 1NZVA 1AYCA 3C7IA 3KFJA 4QSYA 3QWXX 3OB1B 2ECDA 2ETZA 1OO3A 1RPYA 2H5KA 3VS3A 2L3TA 2DM0A 1O4FA 1FYRA 2EL8A 5EHPA 4FL2A 4FBNA 1G83A 2PLEA 3TL0A 3ZNIA 5HKWA 1GRIA 2CR4A 1A1BA 1O4CA 1BFIA 2IUGA 3OP0A 1LCJA 1O4HA 2CRHA 1D1ZA 1P13A 4OHDA 2HDVA 4K44A 2EOBA 4JE4A 2DVJA 1D4TA 1O49A 3VS2A 5DC4A 4K2RA 1PICA 3CD3A 2OQ1A 3OVEA 4ROJA 5J3XA 4H1OA 3S8NA 1Y1UA 4E93A 3K2MA 1X27A 1LUMA 1BG1A 3VRZA 1R1SA 3BUXB 3VRYA 4K45A 3CXLA 1KSWA 3OV1A 1D4WA 3VROA 3VS7A 4M4ZA 1IS0A 2LCTA 1O4OA 4F5AA 1QADA 5HKZA 1OPKA 4JEGA 1O44A 1AOUF 1JYRA 5EELA 1A1AA 2YSXA 2PLDA 2DX0A 4OHHA 5HKYA 2PNAA 5BO4A 5EG3B 1O4RA 1CJ1A 2H46E 3VGOA 4WWQA 2DCRA 4DGXA 2MC1A 1CWDL 2EO3A 3S8OA 2HMHA 2AUGA 3VRPA 3PLFB 4OHLA 4EIHA 2JYQA 4XZ1A 2HCKA 1X6CA 2EYYA 1BMBA 3S8LA 1LUKA 1H9OA 4K11A 1O4GA 1SPRA 1CSZA 1F1WA 2DLYA 1O4LA 1O42A 4U17A 1A1CA 1R1QA 1O4BA 1TCEA 1HCTB 4U1PA 2EYZA 2MK2A 1LUNA 1O4KA 3EAZA 2CI8A 2LNWA 4LUEA 1B47A 2PNBA 3PQZA 3S9KA 2LNXA 4L1BB 4F5BA 1JYUA 1XA6A 1FHSA 1X0NA 3IMDA 2PTKA 3VS0A 1O4MA 2RSYA 5CDWA 2EKXA 2C0TA 3IN8A 3BUOB 1FBZA 1O47A 1LCKA 3N84A 1JWOA 2HDXA 5EHRA 1R1PA 1O45A 1ZFPE 2MRJA 3GQIB 1BM2A 1BLKA 2C0OA 1O4JA 1BKLA 3IMJA 3BKBA 4A4BA 5I6VA 1Y57A 1CSYA 4FL3A 2Y3AB 3EACA 3TKZA 2LQWA 4A4CA 1O48A 2YU7A 4XZ0A 1AD5A 1KC2A 1JU5A 1LKLA 1SKJA 5AULA 5GJIA 5IBMA 1OPLA 1YVHA 2FCIA 3MXCA 2AOAA 2EU0A 1A1EA 4LUDA 2Y1MA 1AYBA 1SHDA 2CI9A 3US4A 4D8KA 5EEQA 1UURA 3NHNA 1JYQA 1BKMA 3N8MA 2BBUA 1QG1E 4GL9E 3QWYA 2RORA 4H34A 1O43A 2ABLA 1RJAA 1K9AA 1YVLA 4GPLB 2CS0A 1I3ZA 3BUWB 4DGPA 1FBVA 5IBSA 1TZEE 1FU6A 1O41A 1QCFA 3GXXA 3BUNB 1FMKA 3VS1A 1LKKA 2DLZA 4P9ZA 3UYOA 1BHFA 5DC0B 4NWGA 3VRQA 2IUIA 1M27A 1MW4A 1AB2A 1RQQC 2MQIA 3CWGA 2B3OA 3PSJA 3VS4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2L4K A;  3N7Y A;  5GJH A;  1F2F A;  2XP1 A;  2Y1N A;  1WQU A;  4F59 A;  3HHM B;  3PFV A;  3VRR A;  3CBL A;  5AXI A;  2CBL A;  1KA6 A;  3MXY A;  2FO0 A;  5DC9 A;  1HCS B;  5KAZ A;  2C0I A;  2HUW A;  1CWE A;  1FU5 A;  1BFJ A;  4EY0 A;  1O4D A;  3VS6 A;  2RVF A;  1O4Q A;  1AYD A;  2H8H A;  2KK6 A;  2EYV A;  1Z3K A;  1A81 A;  1GHU A;  1O4N A;  5DF6 A;  2OZO A;  2KNO A;  3T04 A;  1A07 A;  2IUH A;  1O4E A;  2MRK A;  4E68 A;  2LQN A;  2RMX A;  4OHI A;  2GE9 A;  1NZL A;  3PS5 A;  1LUI A;  3HCK A;  1O4I A;  1SPS A;  3OB2 B;  2K7A B;  3WA4 A;  2SHP A;  1KA7 A;  4GWF A;  1IJR A;  1BHH B;  4TZI A;  1O4A A;  5D0J A;  1O4P A;  2K79 B;  1BHH A;  1SHB A;  4NWF A;  4X6S A;  2EO6 A;  4JGH A;  3VS5 A;  1BF5 A;  1SHA A;  2C9W A;  4OHE A;  1UUS A;  3GXW A;  1BLJ A;  3IN7 A;  3VRN A;  3PJP A;  2L6K A;  3MAZ A;  2IZV A;  2QMS A;  2CIA A;  1M61 A;  1A08 A;  1AYA A;  3M7F A;  3PSK A;  1OO4 A;  1AOT F;  3BUM B;  1O46 A;  3UF4 A;  1A09 A;  1MIL A;  3HIZ B;  2SRC A;  1NRV A;  2GSB A;  2VIF A;  2AOB A;  4P9V A;  1NZV A;  1AYC A;  3C7I A;  3KFJ A;  4QSY A;  3QWX X;  3OB1 B;  2ECD A;  2ETZ A;  1OO3 A;  1RPY A;  2H5K A;  3VS3 A;  2L3T A;  2DM0 A;  1O4F A;  1FYR A;  2EL8 A;  5EHP A;  4FL2 A;  4FBN A;  1G83 A;  2PLE A;  3TL0 A;  3ZNI A;  5HKW A;  1GRI A;  2CR4 A;  1A1B A;  1O4C A;  1BFI A;  2IUG A;  3OP0 A;  1LCJ A;  1O4H A;  2CRH A;  1D1Z A;  1P13 A;  4OHD A;  2HDV A;  4K44 A;  2EOB A;  4JE4 A;  2DVJ A;  1D4T A;  1O49 A;  3VS2 A;  5DC4 A;  4K2R A;  1PIC A;  3CD3 A;  2OQ1 A;  3OVE A;  4ROJ A;  5J3X A;  4H1O A;  3S8N A;  1Y1U A;  4E93 A;  3K2M A;  1X27 A;  1LUM A;  1BG1 A;  3VRZ A;  1R1S A;  3BUX B;  3VRY A;  4K45 A;  3CXL A;  1KSW A;  3OV1 A;  1D4W A;  3VRO A;  3VS7 A;  4M4Z A;  1IS0 A;  2LCT A;  1O4O A;  4F5A A;  1QAD A;  5HKZ A;  1OPK A;  4JEG A;  1O44 A;  1AOU F;  1JYR A;  5EEL A;  1A1A A;  2YSX A;  2PLD A;  2DX0 A;  4OHH A;  5HKY A;  2PNA A;  5BO4 A;  5EG3 B;  1O4R A;  1CJ1 A;  2H46 E;  3VGO A;  4WWQ A;  2DCR A;  4DGX A;  2MC1 A;  1CWD L;  2EO3 A;  3S8O A;  2HMH A;  2AUG A;  3VRP A;  3PLF B;  4OHL A;  4EIH A;  2JYQ A;  4XZ1 A;  2HCK A;  1X6C A;  2EYY A;  1BMB A;  3S8L A;  1LUK A;  1H9O A;  4K11 A;  1O4G A;  1SPR A;  1CSZ A;  1F1W A;  2DLY A;  1O4L A;  1O42 A;  4U17 A;  1A1C A;  1R1Q A;  1O4B A;  1TCE A;  1HCT B;  4U1P A;  2EYZ A;  2MK2 A;  1LUN A;  1O4K A;  3EAZ A;  2CI8 A;  2LNW A;  4LUE A;  1B47 A;  2PNB A;  3PQZ A;  3S9K A;  2LNX A;  4L1B B;  4F5B A;  1JYU A;  1XA6 A;  1FHS A;  1X0N A;  3IMD A;  2PTK A;  3VS0 A;  1O4M A;  2RSY A;  5CDW A;  2EKX A;  2C0T A;  3IN8 A;  3BUO B;  1FBZ A;  1O47 A;  1LCK A;  3N84 A;  1JWO A;  2HDX A;  5EHR A;  1R1P A;  1O45 A;  1ZFP E;  2MRJ A;  3GQI B;  1BM2 A;  1BLK A;  2C0O A;  1O4J A;  1BKL A;  3IMJ A;  3BKB A;  4A4B A;  5I6V A;  1Y57 A;  1CSY A;  4FL3 A;  2Y3A B;  3EAC A;  3TKZ A;  2LQW A;  4A4C A;  1O48 A;  2YU7 A;  4XZ0 A;  1AD5 A;  1KC2 A;  1JU5 A;  1LKL A;  1SKJ A;  5AUL A;  5GJI A;  5IBM A;  1OPL A;  1YVH A;  2FCI A;  3MXC A;  2AOA A;  2EU0 A;  1A1E A;  4LUD A;  2Y1M A;  1AYB A;  1SHD A;  2CI9 A;  3US4 A;  4D8K A;  5EEQ A;  1UUR A;  3NHN A;  1JYQ A;  1BKM A;  3N8M A;  2BBU A;  1QG1 E;  4GL9 E;  3QWY A;  2ROR A;  4H34 A;  1O43 A;  2ABL A;  1RJA A;  1K9A A;  1YVL A;  4GPL B;  2CS0 A;  1I3Z A;  3BUW B;  4DGP A;  1FBV A;  5IBS A;  1TZE E;  1FU6 A;  1O41 A;  1QCF A;  3GXX A;  3BUN B;  1FMK A;  3VS1 A;  1LKK A;  2DLZ A;  4P9Z A;  3UYO A;  1BHF A;  5DC0 B;  4NWG A;  3VRQ A;  2IUI A;  1M27 A;  1MW4 A;  1AB2 A;  1RQQ C;  2MQI A;  3CWG A;  2B3O A;  3PSJ A;  3VS4 A; 
#chains in the Genus database with same CATH topology
 2L4K A;  3N7Y A;  5GJH A;  1F2F A;  2XP1 A;  2Y1N A;  1WQU A;  4F59 A;  3HHM B;  3PFV A;  3VRR A;  3CBL A;  5AXI A;  2CBL A;  1KA6 A;  3MXY A;  2FO0 A;  5DC9 A;  1HCS B;  5KAZ A;  2C0I A;  2HUW A;  1CWE A;  1FU5 A;  1BFJ A;  4EY0 A;  1O4D A;  3VS6 A;  2RVF A;  1O4Q A;  1AYD A;  2H8H A;  2KK6 A;  2EYV A;  1Z3K A;  1A81 A;  1GHU A;  1O4N A;  5DF6 A;  2OZO A;  2KNO A;  3T04 A;  1A07 A;  2IUH A;  1O4E A;  2MRK A;  4E68 A;  2LQN A;  2RMX A;  4OHI A;  2GE9 A;  1NZL A;  3PS5 A;  1LUI A;  3HCK A;  1O4I A;  1SPS A;  3OB2 B;  2K7A B;  3WA4 A;  2SHP A;  1KA7 A;  4GWF A;  1IJR A;  1BHH B;  4TZI A;  1O4A A;  5D0J A;  1O4P A;  2K79 B;  1BHH A;  1SHB A;  4NWF A;  4X6S A;  2EO6 A;  4JGH A;  3VS5 A;  1BF5 A;  3K2T A;  1SHA A;  2C9W A;  4OHE A;  1UUS A;  3GXW A;  1BLJ A;  3IN7 A;  3VRN A;  3PJP A;  2L6K A;  3MAZ A;  2IZV A;  2QMS A;  2CIA A;  1M61 A;  1A08 A;  1AYA A;  3M7F A;  3PSK A;  1OO4 A;  1AOT F;  3BUM B;  1O46 A;  3UF4 A;  1A09 A;  1MIL A;  3HIZ B;  2SRC A;  1NRV A;  2GSB A;  2VIF A;  2AOB A;  4P9V A;  1NZV A;  1AYC A;  3C7I A;  3KFJ A;  4QSY A;  3QWX X;  3OB1 B;  2ECD A;  2ETZ A;  1OO3 A;  1RPY A;  2H5K A;  3VS3 A;  3LYV A;  2KGY A;  2L3T A;  2DM0 A;  1O4F A;  1FYR A;  2EL8 A;  5EHP A;  4FL2 A;  4FBN A;  1G83 A;  2PLE A;  3TL0 A;  3ZNI A;  5HKW A;  1GRI A;  2CR4 A;  1A1B A;  1O4C A;  1BFI A;  2IUG A;  3OP0 A;  1LCJ A;  1O4H A;  2CRH A;  1D1Z A;  1P13 A;  4OHD A;  2HDV A;  4K44 A;  2EOB A;  4JE4 A;  2DVJ A;  1D4T A;  1O49 A;  3VS2 A;  5DC4 A;  4K2R A;  1PIC A;  3CD3 A;  2OQ1 A;  3OVE A;  4ROJ A;  5J3X A;  4H1O A;  3S8N A;  1Y1U A;  4E93 A;  3K2M A;  1X27 A;  1LUM A;  1BG1 A;  3VRZ A;  1R1S A;  3BUX B;  3VRY A;  4K45 A;  3CXL A;  1KSW A;  3OV1 A;  1D4W A;  3VRO A;  3VS7 A;  4M4Z A;  1IS0 A;  2LCT A;  1O4O A;  4F5A A;  1QAD A;  5HKZ A;  1OPK A;  4JEG A;  1O44 A;  1AOU F;  1JYR A;  5EEL A;  1A1A A;  2YSX A;  2PLD A;  2DX0 A;  4OHH A;  5HKY A;  2PNA A;  5BO4 A;  5EG3 B;  1O4R A;  1CJ1 A;  2H46 E;  3VGO A;  4WWQ A;  2DCR A;  4DGX A;  2MC1 A;  1CWD L;  2EO3 A;  3S8O A;  2HMH A;  2AUG A;  3VRP A;  3PLF B;  4OHL A;  4EIH A;  2JYQ A;  4XZ1 A;  2HCK A;  1X6C A;  2EYY A;  1BMB A;  3S8L A;  1LUK A;  1H9O A;  4K11 A;  1O4G A;  1SPR A;  1CSZ A;  1F1W A;  2DLY A;  1O4L A;  1O42 A;  4U17 A;  1A1C A;  1R1Q A;  1O4B A;  1TCE A;  1HCT B;  4U1P A;  2EYZ A;  2MK2 A;  1LUN A;  1O4K A;  3EAZ A;  2CI8 A;  2LNW A;  4LUE A;  1B47 A;  2PNB A;  3PQZ A;  3S9K A;  2LNX A;  4L1B B;  4F5B A;  1JYU A;  1XA6 A;  1FHS A;  1X0N A;  3IMD A;  2PTK A;  3VS0 A;  1O4M A;  2RSY A;  5CDW A;  2EKX A;  2C0T A;  3IN8 A;  3BUO B;  1FBZ A;  1O47 A;  1LCK A;  3N84 A;  1JWO A;  2HDX A;  5EHR A;  1R1P A;  1O45 A;  1ZFP E;  2MRJ A;  3GQI B;  1BM2 A;  1BLK A;  2C0O A;  1O4J A;  1BKL A;  3IMJ A;  3BKB A;  4A4B A;  5I6V A;  1Y57 A;  1CSY A;  4FL3 A;  2Y3A B;  3EAC A;  3TKZ A;  2LRA A;  2LQW A;  4A4C A;  1O48 A;  2YU7 A;  4XZ0 A;  1AD5 A;  1KC2 A;  1JU5 A;  1LKL A;  1SKJ A;  5AUL A;  5GJI A;  5IBM A;  1OPL A;  1YVH A;  2FCI A;  3MXC A;  2AOA A;  2EU0 A;  1A1E A;  4LUD A;  2Y1M A;  1AYB A;  1SHD A;  2CI9 A;  3US4 A;  4D8K A;  5EEQ A;  1UUR A;  3NHN A;  1JYQ A;  1BKM A;  3N8M A;  2BBU A;  1QG1 E;  4GL9 E;  3QWY A;  2ROR A;  4H34 A;  1O43 A;  2ABL A;  1RJA A;  1K9A A;  1YVL A;  4GPL B;  2CS0 A;  1I3Z A;  3BUW B;  4DGP A;  1FBV A;  5IBS A;  1TZE E;  1FU6 A;  1O41 A;  1QCF A;  3GXX A;  3BUN B;  1FMK A;  3VS1 A;  1LKK A;  2DLZ A;  4P9Z A;  3UYO A;  1BHF A;  5DC0 B;  4NWG A;  3VRQ A;  2IUI A;  1M27 A;  1MW4 A;  1AB2 A;  1RQQ C;  2MQI A;  3CWG A;  2B3O A;  3PSJ A;  3VS4 A; 
#chains in the Genus database with same CATH homology
 2L4K A;  3N7Y A;  5GJH A;  1F2F A;  2XP1 A;  2Y1N A;  1WQU A;  4F59 A;  3HHM B;  3PFV A;  3VRR A;  3CBL A;  5AXI A;  2CBL A;  1KA6 A;  3MXY A;  2FO0 A;  5DC9 A;  1HCS B;  5KAZ A;  2C0I A;  2HUW A;  1CWE A;  1FU5 A;  1BFJ A;  4EY0 A;  1O4D A;  3VS6 A;  2RVF A;  1O4Q A;  1AYD A;  2H8H A;  2KK6 A;  2EYV A;  1Z3K A;  1A81 A;  1GHU A;  1O4N A;  5DF6 A;  2OZO A;  2KNO A;  3T04 A;  1A07 A;  2IUH A;  1O4E A;  2MRK A;  4E68 A;  2LQN A;  2RMX A;  4OHI A;  2GE9 A;  1NZL A;  3PS5 A;  1LUI A;  3HCK A;  1O4I A;  1SPS A;  3OB2 B;  2K7A B;  3WA4 A;  2SHP A;  1KA7 A;  4GWF A;  1IJR A;  1BHH B;  4TZI A;  1O4A A;  5D0J A;  1O4P A;  2K79 B;  1BHH A;  1SHB A;  4NWF A;  4X6S A;  2EO6 A;  4JGH A;  3VS5 A;  1BF5 A;  1SHA A;  2C9W A;  4OHE A;  1UUS A;  3GXW A;  1BLJ A;  3IN7 A;  3VRN A;  3PJP A;  2L6K A;  3MAZ A;  2IZV A;  2QMS A;  2CIA A;  1M61 A;  1A08 A;  1AYA A;  3M7F A;  3PSK A;  1OO4 A;  1AOT F;  3BUM B;  1O46 A;  3UF4 A;  1A09 A;  1MIL A;  3HIZ B;  2SRC A;  1NRV A;  2GSB A;  2VIF A;  2AOB A;  4P9V A;  1NZV A;  1AYC A;  3C7I A;  3KFJ A;  4QSY A;  3QWX X;  3OB1 B;  2ECD A;  2ETZ A;  1OO3 A;  1RPY A;  2H5K A;  3VS3 A;  2L3T A;  2DM0 A;  1O4F A;  1FYR A;  2EL8 A;  5EHP A;  4FL2 A;  4FBN A;  1G83 A;  2PLE A;  3TL0 A;  3ZNI A;  5HKW A;  1GRI A;  2CR4 A;  1A1B A;  1O4C A;  1BFI A;  2IUG A;  3OP0 A;  1LCJ A;  1O4H A;  2CRH A;  1D1Z A;  1P13 A;  4OHD A;  2HDV A;  4K44 A;  2EOB A;  4JE4 A;  2DVJ A;  1D4T A;  1O49 A;  3VS2 A;  5DC4 A;  4K2R A;  1PIC A;  3CD3 A;  2OQ1 A;  3OVE A;  4ROJ A;  5J3X A;  4H1O A;  3S8N A;  1Y1U A;  4E93 A;  3K2M A;  1X27 A;  1LUM A;  1BG1 A;  3VRZ A;  1R1S A;  3BUX B;  3VRY A;  4K45 A;  3CXL A;  1KSW A;  3OV1 A;  1D4W A;  3VRO A;  3VS7 A;  4M4Z A;  1IS0 A;  2LCT A;  1O4O A;  4F5A A;  1QAD A;  5HKZ A;  1OPK A;  4JEG A;  1O44 A;  1AOU F;  1JYR A;  5EEL A;  1A1A A;  2YSX A;  2PLD A;  2DX0 A;  4OHH A;  5HKY A;  2PNA A;  5BO4 A;  5EG3 B;  1O4R A;  1CJ1 A;  2H46 E;  3VGO A;  4WWQ A;  2DCR A;  4DGX A;  2MC1 A;  1CWD L;  2EO3 A;  3S8O A;  2HMH A;  2AUG A;  3VRP A;  3PLF B;  4OHL A;  4EIH A;  2JYQ A;  4XZ1 A;  2HCK A;  1X6C A;  2EYY A;  1BMB A;  3S8L A;  1LUK A;  1H9O A;  4K11 A;  1O4G A;  1SPR A;  1CSZ A;  1F1W A;  2DLY A;  1O4L A;  1O42 A;  4U17 A;  1A1C A;  1R1Q A;  1O4B A;  1TCE A;  1HCT B;  4U1P A;  2EYZ A;  2MK2 A;  1LUN A;  1O4K A;  3EAZ A;  2CI8 A;  2LNW A;  4LUE A;  1B47 A;  2PNB A;  3PQZ A;  3S9K A;  2LNX A;  4L1B B;  4F5B A;  1JYU A;  1XA6 A;  1FHS A;  1X0N A;  3IMD A;  2PTK A;  3VS0 A;  1O4M A;  2RSY A;  5CDW A;  2EKX A;  2C0T A;  3IN8 A;  3BUO B;  1FBZ A;  1O47 A;  1LCK A;  3N84 A;  1JWO A;  2HDX A;  5EHR A;  1R1P A;  1O45 A;  1ZFP E;  2MRJ A;  3GQI B;  1BM2 A;  1BLK A;  2C0O A;  1O4J A;  1BKL A;  3IMJ A;  3BKB A;  4A4B A;  5I6V A;  1Y57 A;  1CSY A;  4FL3 A;  2Y3A B;  3EAC A;  3TKZ A;  2LQW A;  4A4C A;  1O48 A;  2YU7 A;  4XZ0 A;  1AD5 A;  1KC2 A;  1JU5 A;  1LKL A;  1SKJ A;  5AUL A;  5GJI A;  5IBM A;  1OPL A;  1YVH A;  2FCI A;  3MXC A;  2AOA A;  2EU0 A;  1A1E A;  4LUD A;  2Y1M A;  1AYB A;  1SHD A;  2CI9 A;  3US4 A;  4D8K A;  5EEQ A;  1UUR A;  3NHN A;  1JYQ A;  1BKM A;  3N8M A;  2BBU A;  1QG1 E;  4GL9 E;  3QWY A;  2ROR A;  4H34 A;  1O43 A;  2ABL A;  1RJA A;  1K9A A;  1YVL A;  4GPL B;  2CS0 A;  1I3Z A;  3BUW B;  4DGP A;  1FBV A;  5IBS A;  1TZE E;  1FU6 A;  1O41 A;  1QCF A;  3GXX A;  3BUN B;  1FMK A;  3VS1 A;  1LKK A;  2DLZ A;  4P9Z A;  3UYO A;  1BHF A;  5DC0 B;  4NWG A;  3VRQ A;  2IUI A;  1M27 A;  1MW4 A;  1AB2 A;  1RQQ C;  2MQI A;  3CWG A;  2B3O A;  3PSJ A;  3VS4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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