2HUWA

X-ray crystal structure of the grb2 sh2 domain complexed to a constrained and cyclopropane-derived ligand
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
101
structure length
101
Chain Sequence
MKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Ligand Preorganization May Be Accompanied by Entropic Penalties in Protein-Ligand Interactions.
pubmed doi rcsb
molecule tags Hormone/growth factor
source organism Homo sapiens
molecule keywords Growth factor receptor-bound protein 2
total genus 25
structure length 101
sequence length 101
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-07-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00017 SH2 SH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 2huwA00
3PQZA 1SHBA 1HCSB 2C0IA 4OHEA 4EY0A 2EU0A 1O4KA 4U17A 4F59A 3HIZB 1YVHA 2CIAA 2Y1MA 1OO4A 1O4JA 1OPLA 1QCFA 2EO3A 2DVJA 3BUXB 2H8HA 1TZEE 5EHRA 4EIHA 1O46A 3HCKA 1AYBA 1X6CA 2IUGA 1O4LA 2DLYA 5IBSA 1LUMA 2LNXA 1KC2A 3EAZA 3IMDA 3S8LA 4P9ZA 4E93A 1MILA 2EKXA 1BM2A 3OVEA 5HKZA 4A4CA 1BG1A 2MC1A 3VS5A 4ROJA 2KK6A 1IJRA 3IN7A 3GXWA 1O47A 2LCTA 4U1PA 4FL3A 1LCKA 2C9WA 1LCJA 1BHFA 1FBZA 1M27A 1O4FA 1A07A 2PLDA 1AYDA 2DM0A 2VIFA 2AUGA 2AOBA 1AOUF 5DF6A 4JEGA 4F5BA 1A1CA 1O4CA 5EELA 3QWYA 1GRIA 3HHMB 2CI9A 1BHHB 2CRHA 3OB2B 3TL0A 1BMBA 4GPLB 2CS0A 3CWGA 1O43A 2LNWA 1TCEA 3CBLA 2HDXA 2YU7A 4X6SA 3VS1A 1O4RA 1SHDA 2XP1A 2KNOA 4XZ0A 3VRNA 3TKZA 5I6VA 1PICA 1WQUA 4K45A 4P9VA 1YVLA 3EACA 1KSWA 3OB1B 1FYRA 3US4A 1OO3A 1AYCA 2JYQA 1M61A 1LKLA 1A08A 2MRJA 1SPSA 2OZOA 3CD3A 5HKWA 5GJIA 2OQ1A 3PSKA 1JWOA 2BBUA 3VS2A 1SHAA 3CXLA 5J3XA 4JGHA 1CWDL 1B47A 4NWFA 1BFJA 1O45A 4GL9E 2L3TA 1O4BA 1QADA 1R1QA 3N8MA 1Y1UA 3VS6A 1X0NA 4GWFA 2GE9A 3UF4A 1I3ZA 1O4DA 1SKJA 2Y1NA 4K2RA 1NRVA 3KFJA 2HDVA 2RVFA 1A1EA 1O4QA 3T04A 4K44A 4TZIA 2RMXA 1JYRA 3IMJA 3ZNIA 4H34A 2HCKA 2K79B 2EL8A 2C0OA 1O44A 2EYYA 3M7FA 5DC4A 2LQWA 2DCRA 1A81A 1A1AA 2SRCA 1MW4A 3N7YA 1FBVA 1UUSA 3K2MA 5GJHA 1FU6A 1Z3KA 3VS0A 2B3OA 2MRKA 3VROA 1AB2A 1LUIA 3PFVA 2IUHA 1O4GA 2DX0A 4XZ1A 1O4MA 1O4IA 1NZLA 1A09A 1O4EA 3C7IA 4OHLA 2CR4A 1OPKA 1R1PA 2H5KA 2PLEA 2K7AB 1O4OA 2Y3AB 2FO0A 3VS3A 1AYAA 4F5AA 1R1SA 2CBLA 1Y57A 2PNAA 1BLKA 2QMSA 3MXYA 2IZVA 2FCIA 1HCTB 4NWGA 5DC9A 2RSYA 3VGOA 4QSYA 3IN8A 2RORA 3PJPA 2MK2A 1D1ZA 1RJAA 1G83A 1SPRA 1A1BA 3VRQA 1CWEA 2ABLA 2ETZA 1BKLA 1RPYA 4K11A 4L1BB 3VRYA 2H46E 5EEQA 5KAZA 1BFIA 1NZVA 4H1OA 1GHUA 1F1WA 1AD5A 1O42A 5EG3B 4LUDA 2YSXA 4OHIA 4JE4A 5CDWA 3PSJA 3NHNA 3QWXX 5D0JA 1O4AA 1H9OA 1O4HA 1F2FA 4E68A 1BLJA 1CJ1A 1O4PA 2PTKA 1O49A 5BO4A 3S8OA 3GXXA 1XA6A 1IS0A 3S8NA 4D8KA 1O41A 4DGPA 2HUWA 1O48A 3VS4A 5AULA 1KA7A 1FU5A 1FHSA 3MAZA 5EHPA 3S9KA 1LKKA 1CSZA 1O4NA 1ZFPE 3BKBA 4FBNA 3BUMB 2LQNA 1JYQA 2L4KA 3PS5A 4DGXA 5HKYA 3UYOA 4OHHA 2EYZA 3N84A 5AXIA 2EO6A 1UURA 2EYVA 3VRZA 1QG1E 3WA4A 2CI8A 2GSBA 2SHPA 3VS7A 4FL2A 4LUEA 1JU5A 3MXCA 1X27A 4OHDA 3BUNB 4A4BA 1D4TA 1BHHA 2C0TA 3GQIB 1D4WA 3VRPA 2ECDA 3OP0A 1KA6A 2EOBA 2MQIA 3OV1A 2L6KA 4M4ZA 1FMKA 1CSYA 1LUNA 1JYUA 1P13A 2IUIA 1K9AA 3BUOB 2DLZA 1BF5A 2AOAA 5IBMA 1BKMA 3PLFB 1LUKA 2HMHA 5DC0B 3VRRA 3BUWB 4WWQA 1AOTF 1RQQC 2PNBA
chains in the Genus database with same CATH superfamily
3PQZA 1SHBA 1HCSB 2C0IA 4OHEA 4EY0A 2EU0A 1O4KA 4U17A 4F59A 3HIZB 1YVHA 2CIAA 2Y1MA 1OO4A 1O4JA 1OPLA 1QCFA 2EO3A 2DVJA 3BUXB 2H8HA 1TZEE 5EHRA 4EIHA 1O46A 3HCKA 1AYBA 1X6CA 2IUGA 1O4LA 2DLYA 5IBSA 1LUMA 2LNXA 1KC2A 3EAZA 3IMDA 3S8LA 4P9ZA 4E93A 1MILA 2EKXA 1BM2A 3OVEA 5HKZA 4A4CA 1BG1A 2MC1A 3VS5A 4ROJA 2KK6A 1IJRA 3IN7A 3GXWA 1O47A 2LCTA 4U1PA 4FL3A 1LCKA 2C9WA 1LCJA 1BHFA 1FBZA 1M27A 1O4FA 1A07A 2PLDA 1AYDA 2DM0A 2VIFA 2AUGA 2AOBA 1AOUF 5DF6A 4JEGA 4F5BA 1A1CA 1O4CA 5EELA 3QWYA 1GRIA 3HHMB 2CI9A 1BHHB 2CRHA 3OB2B 3TL0A 3LYVA 1BMBA 4GPLB 2CS0A 3CWGA 1O43A 2LNWA 1TCEA 3CBLA 2HDXA 2YU7A 4X6SA 3VS1A 1O4RA 2KGYA 1SHDA 2XP1A 2KNOA 4XZ0A 3VRNA 3TKZA 5I6VA 1PICA 1WQUA 4K45A 4P9VA 1YVLA 3EACA 1KSWA 3OB1B 1FYRA 3US4A 1OO3A 1AYCA 2JYQA 1M61A 1LKLA 1A08A 2MRJA 1SPSA 2OZOA 3CD3A 5HKWA 5GJIA 2OQ1A 3PSKA 1JWOA 2BBUA 3VS2A 1SHAA 3CXLA 5J3XA 4JGHA 1CWDL 1B47A 4NWFA 1BFJA 1O45A 4GL9E 2L3TA 1O4BA 1QADA 3K2TA 1R1QA 3N8MA 1Y1UA 3VS6A 1X0NA 4GWFA 2GE9A 3UF4A 1I3ZA 1O4DA 1SKJA 2Y1NA 4K2RA 1NRVA 3KFJA 2HDVA 2RVFA 1A1EA 1O4QA 3T04A 4K44A 4TZIA 2RMXA 1JYRA 3IMJA 3ZNIA 4H34A 2HCKA 2K79B 2EL8A 2C0OA 1O44A 2EYYA 3M7FA 5DC4A 2LQWA 2DCRA 1A81A 1A1AA 2SRCA 1MW4A 3N7YA 1FBVA 1UUSA 3K2MA 5GJHA 1FU6A 1Z3KA 3VS0A 2B3OA 2MRKA 3VROA 1AB2A 1LUIA 3PFVA 2IUHA 1O4GA 2DX0A 4XZ1A 1O4MA 1O4IA 1NZLA 1A09A 1O4EA 3C7IA 4OHLA 2CR4A 1OPKA 1R1PA 2H5KA 2PLEA 2K7AB 1O4OA 2Y3AB 2FO0A 3VS3A 1AYAA 4F5AA 1R1SA 2CBLA 1Y57A 2PNAA 1BLKA 2QMSA 3MXYA 2IZVA 2FCIA 1HCTB 4NWGA 5DC9A 2RSYA 3VGOA 4QSYA 3IN8A 2RORA 3PJPA 2MK2A 1D1ZA 1RJAA 1G83A 1SPRA 1A1BA 3VRQA 1CWEA 2ABLA 2ETZA 1BKLA 1RPYA 4K11A 4L1BB 3VRYA 2H46E 5EEQA 5KAZA 1BFIA 1NZVA 4H1OA 1GHUA 1F1WA 1AD5A 1O42A 5EG3B 4LUDA 2YSXA 4OHIA 4JE4A 5CDWA 3PSJA 3NHNA 3QWXX 5D0JA 1O4AA 1H9OA 1O4HA 1F2FA 4E68A 1BLJA 1CJ1A 1O4PA 2PTKA 1O49A 5BO4A 3S8OA 3GXXA 1XA6A 1IS0A 3S8NA 4D8KA 1O41A 4DGPA 2HUWA 1O48A 3VS4A 5AULA 1KA7A 1FU5A 1FHSA 3MAZA 5EHPA 3S9KA 1LKKA 1CSZA 1O4NA 1ZFPE 3BKBA 4FBNA 3BUMB 2LQNA 1JYQA 2L4KA 3PS5A 4DGXA 5HKYA 3UYOA 4OHHA 2EYZA 3N84A 5AXIA 2EO6A 1UURA 2EYVA 3VRZA 1QG1E 3WA4A 2CI8A 2GSBA 2SHPA 3VS7A 4FL2A 4LUEA 1JU5A 3MXCA 2LRAA 1X27A 4OHDA 3BUNB 4A4BA 1D4TA 1BHHA 2C0TA 3GQIB 1D4WA 3VRPA 2ECDA 3OP0A 1KA6A 2EOBA 2MQIA 3OV1A 2L6KA 4M4ZA 1FMKA 1CSYA 1LUNA 1JYUA 1P13A 2IUIA 1K9AA 3BUOB 2DLZA 1BF5A 2AOAA 5IBMA 1BKMA 3PLFB 1LUKA 2HMHA 5DC0B 3VRRA 3BUWB 4WWQA 1AOTF 1RQQC 2PNBA
chains in the Genus database with same CATH topology
3PQZA 1SHBA 1HCSB 2C0IA 4OHEA 4EY0A 2EU0A 1O4KA 4U17A 4F59A 3HIZB 1YVHA 2CIAA 2Y1MA 1OO4A 1O4JA 1OPLA 1QCFA 2EO3A 2DVJA 3BUXB 2H8HA 1TZEE 5EHRA 4EIHA 1O46A 3HCKA 1AYBA 1X6CA 2IUGA 1O4LA 2DLYA 5IBSA 1LUMA 2LNXA 1KC2A 3EAZA 3IMDA 3S8LA 4P9ZA 4E93A 1MILA 2EKXA 1BM2A 3OVEA 5HKZA 4A4CA 1BG1A 2MC1A 3VS5A 4ROJA 2KK6A 1IJRA 3IN7A 3GXWA 1O47A 2LCTA 4U1PA 4FL3A 1LCKA 2C9WA 1LCJA 1BHFA 1FBZA 1M27A 1O4FA 1A07A 2PLDA 1AYDA 2DM0A 2VIFA 2AUGA 2AOBA 1AOUF 5DF6A 4JEGA 4F5BA 1A1CA 1O4CA 5EELA 3QWYA 1GRIA 3HHMB 2CI9A 1BHHB 2CRHA 3OB2B 3TL0A 1BMBA 4GPLB 2CS0A 3CWGA 1O43A 2LNWA 1TCEA 3CBLA 2HDXA 2YU7A 4X6SA 3VS1A 1O4RA 1SHDA 2XP1A 2KNOA 4XZ0A 3VRNA 3TKZA 5I6VA 1PICA 1WQUA 4K45A 4P9VA 1YVLA 3EACA 1KSWA 3OB1B 1FYRA 3US4A 1OO3A 1AYCA 2JYQA 1M61A 1LKLA 1A08A 2MRJA 1SPSA 2OZOA 3CD3A 5HKWA 5GJIA 2OQ1A 3PSKA 1JWOA 2BBUA 3VS2A 1SHAA 3CXLA 5J3XA 4JGHA 1CWDL 1B47A 4NWFA 1BFJA 1O45A 4GL9E 2L3TA 1O4BA 1QADA 1R1QA 3N8MA 1Y1UA 3VS6A 1X0NA 4GWFA 2GE9A 3UF4A 1I3ZA 1O4DA 1SKJA 2Y1NA 4K2RA 1NRVA 3KFJA 2HDVA 2RVFA 1A1EA 1O4QA 3T04A 4K44A 4TZIA 2RMXA 1JYRA 3IMJA 3ZNIA 4H34A 2HCKA 2K79B 2EL8A 2C0OA 1O44A 2EYYA 3M7FA 5DC4A 2LQWA 2DCRA 1A81A 1A1AA 2SRCA 1MW4A 3N7YA 1FBVA 1UUSA 3K2MA 5GJHA 1FU6A 1Z3KA 3VS0A 2B3OA 2MRKA 3VROA 1AB2A 1LUIA 3PFVA 2IUHA 1O4GA 2DX0A 4XZ1A 1O4MA 1O4IA 1NZLA 1A09A 1O4EA 3C7IA 4OHLA 2CR4A 1OPKA 1R1PA 2H5KA 2PLEA 2K7AB 1O4OA 2Y3AB 2FO0A 3VS3A 1AYAA 4F5AA 1R1SA 2CBLA 1Y57A 2PNAA 1BLKA 2QMSA 3MXYA 2IZVA 2FCIA 1HCTB 4NWGA 5DC9A 2RSYA 3VGOA 4QSYA 3IN8A 2RORA 3PJPA 2MK2A 1D1ZA 1RJAA 1G83A 1SPRA 1A1BA 3VRQA 1CWEA 2ABLA 2ETZA 1BKLA 1RPYA 4K11A 4L1BB 3VRYA 2H46E 5EEQA 5KAZA 1BFIA 1NZVA 4H1OA 1GHUA 1F1WA 1AD5A 1O42A 5EG3B 4LUDA 2YSXA 4OHIA 4JE4A 5CDWA 3PSJA 3NHNA 3QWXX 5D0JA 1O4AA 1H9OA 1O4HA 1F2FA 4E68A 1BLJA 1CJ1A 1O4PA 2PTKA 1O49A 5BO4A 3S8OA 3GXXA 1XA6A 1IS0A 3S8NA 4D8KA 1O41A 4DGPA 2HUWA 1O48A 3VS4A 5AULA 1KA7A 1FU5A 1FHSA 3MAZA 5EHPA 3S9KA 1LKKA 1CSZA 1O4NA 1ZFPE 3BKBA 4FBNA 3BUMB 2LQNA 1JYQA 2L4KA 3PS5A 4DGXA 5HKYA 3UYOA 4OHHA 2EYZA 3N84A 5AXIA 2EO6A 1UURA 2EYVA 3VRZA 1QG1E 3WA4A 2CI8A 2GSBA 2SHPA 3VS7A 4FL2A 4LUEA 1JU5A 3MXCA 1X27A 4OHDA 3BUNB 4A4BA 1D4TA 1BHHA 2C0TA 3GQIB 1D4WA 3VRPA 2ECDA 3OP0A 1KA6A 2EOBA 2MQIA 3OV1A 2L6KA 4M4ZA 1FMKA 1CSYA 1LUNA 1JYUA 1P13A 2IUIA 1K9AA 3BUOB 2DLZA 1BF5A 2AOAA 5IBMA 1BKMA 3PLFB 1LUKA 2HMHA 5DC0B 3VRRA 3BUWB 4WWQA 1AOTF 1RQQC 2PNBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3PQZ A;  1SHB A;  1HCS B;  2C0I A;  4OHE A;  4EY0 A;  2EU0 A;  1O4K A;  4U17 A;  4F59 A;  3HIZ B;  1YVH A;  2CIA A;  2Y1M A;  1OO4 A;  1O4J A;  1OPL A;  1QCF A;  2EO3 A;  2DVJ A;  3BUX B;  2H8H A;  1TZE E;  5EHR A;  4EIH A;  1O46 A;  3HCK A;  1AYB A;  1X6C A;  2IUG A;  1O4L A;  2DLY A;  5IBS A;  1LUM A;  2LNX A;  1KC2 A;  3EAZ A;  3IMD A;  3S8L A;  4P9Z A;  4E93 A;  1MIL A;  2EKX A;  1BM2 A;  3OVE A;  5HKZ A;  4A4C A;  1BG1 A;  2MC1 A;  3VS5 A;  4ROJ A;  2KK6 A;  1IJR A;  3IN7 A;  3GXW A;  1O47 A;  2LCT A;  4U1P A;  4FL3 A;  1LCK A;  2C9W A;  1LCJ A;  1BHF A;  1FBZ A;  1M27 A;  1O4F A;  1A07 A;  2PLD A;  1AYD A;  2DM0 A;  2VIF A;  2AUG A;  2AOB A;  1AOU F;  5DF6 A;  4JEG A;  4F5B A;  1A1C A;  1O4C A;  5EEL A;  3QWY A;  1GRI A;  3HHM B;  2CI9 A;  1BHH B;  2CRH A;  3OB2 B;  3TL0 A;  1BMB A;  4GPL B;  2CS0 A;  3CWG A;  1O43 A;  2LNW A;  1TCE A;  3CBL A;  2HDX A;  2YU7 A;  4X6S A;  3VS1 A;  1O4R A;  1SHD A;  2XP1 A;  2KNO A;  4XZ0 A;  3VRN A;  3TKZ A;  5I6V A;  1PIC A;  1WQU A;  4K45 A;  4P9V A;  1YVL A;  3EAC A;  1KSW A;  3OB1 B;  1FYR A;  3US4 A;  1OO3 A;  1AYC A;  2JYQ A;  1M61 A;  1LKL A;  1A08 A;  2MRJ A;  1SPS A;  2OZO A;  3CD3 A;  5HKW A;  5GJI A;  2OQ1 A;  3PSK A;  1JWO A;  2BBU A;  3VS2 A;  1SHA A;  3CXL A;  5J3X A;  4JGH A;  1CWD L;  1B47 A;  4NWF A;  1BFJ A;  1O45 A;  4GL9 E;  2L3T A;  1O4B A;  1QAD A;  1R1Q A;  3N8M A;  1Y1U A;  3VS6 A;  1X0N A;  4GWF A;  2GE9 A;  3UF4 A;  1I3Z A;  1O4D A;  1SKJ A;  2Y1N A;  4K2R A;  1NRV A;  3KFJ A;  2HDV A;  2RVF A;  1A1E A;  1O4Q A;  3T04 A;  4K44 A;  4TZI A;  2RMX A;  1JYR A;  3IMJ A;  3ZNI A;  4H34 A;  2HCK A;  2K79 B;  2EL8 A;  2C0O A;  1O44 A;  2EYY A;  3M7F A;  5DC4 A;  2LQW A;  2DCR A;  1A81 A;  1A1A A;  2SRC A;  1MW4 A;  3N7Y A;  1FBV A;  1UUS A;  3K2M A;  5GJH A;  1FU6 A;  1Z3K A;  3VS0 A;  2B3O A;  2MRK A;  3VRO A;  1AB2 A;  1LUI A;  3PFV A;  2IUH A;  1O4G A;  2DX0 A;  4XZ1 A;  1O4M A;  1O4I A;  1NZL A;  1A09 A;  1O4E A;  3C7I A;  4OHL A;  2CR4 A;  1OPK A;  1R1P A;  2H5K A;  2PLE A;  2K7A B;  1O4O A;  2Y3A B;  2FO0 A;  3VS3 A;  1AYA A;  4F5A A;  1R1S A;  2CBL A;  1Y57 A;  2PNA A;  1BLK A;  2QMS A;  3MXY A;  2IZV A;  2FCI A;  1HCT B;  4NWG A;  5DC9 A;  2RSY A;  3VGO A;  4QSY A;  3IN8 A;  2ROR A;  3PJP A;  2MK2 A;  1D1Z A;  1RJA A;  1G83 A;  1SPR A;  1A1B A;  3VRQ A;  1CWE A;  2ABL A;  2ETZ A;  1BKL A;  1RPY A;  4K11 A;  4L1B B;  3VRY A;  2H46 E;  5EEQ A;  5KAZ A;  1BFI A;  1NZV A;  4H1O A;  1GHU A;  1F1W A;  1AD5 A;  1O42 A;  5EG3 B;  4LUD A;  2YSX A;  4OHI A;  4JE4 A;  5CDW A;  3PSJ A;  3NHN A;  3QWX X;  5D0J A;  1O4A A;  1H9O A;  1O4H A;  1F2F A;  4E68 A;  1BLJ A;  1CJ1 A;  1O4P A;  2PTK A;  1O49 A;  5BO4 A;  3S8O A;  3GXX A;  1XA6 A;  1IS0 A;  3S8N A;  4D8K A;  1O41 A;  4DGP A;  2HUW A;  1O48 A;  3VS4 A;  5AUL A;  1KA7 A;  1FU5 A;  1FHS A;  3MAZ A;  5EHP A;  3S9K A;  1LKK A;  1CSZ A;  1O4N A;  1ZFP E;  3BKB A;  4FBN A;  3BUM B;  2LQN A;  1JYQ A;  2L4K A;  3PS5 A;  4DGX A;  5HKY A;  3UYO A;  4OHH A;  2EYZ A;  3N84 A;  5AXI A;  2EO6 A;  1UUR A;  2EYV A;  3VRZ A;  1QG1 E;  3WA4 A;  2CI8 A;  2GSB A;  2SHP A;  3VS7 A;  4FL2 A;  4LUE A;  1JU5 A;  3MXC A;  1X27 A;  4OHD A;  3BUN B;  4A4B A;  1D4T A;  1BHH A;  2C0T A;  3GQI B;  1D4W A;  3VRP A;  2ECD A;  3OP0 A;  1KA6 A;  2EOB A;  2MQI A;  3OV1 A;  2L6K A;  4M4Z A;  1FMK A;  1CSY A;  1LUN A;  1JYU A;  1P13 A;  2IUI A;  1K9A A;  3BUO B;  2DLZ A;  1BF5 A;  2AOA A;  5IBM A;  1BKM A;  3PLF B;  1LUK A;  2HMH A;  5DC0 B;  3VRR A;  3BUW B;  4WWQ A;  1AOT F;  1RQQ C;  2PNB A; 
#chains in the Genus database with same CATH topology
 3PQZ A;  1SHB A;  1HCS B;  2C0I A;  4OHE A;  4EY0 A;  2EU0 A;  1O4K A;  4U17 A;  4F59 A;  3HIZ B;  1YVH A;  2CIA A;  2Y1M A;  1OO4 A;  1O4J A;  1OPL A;  1QCF A;  2EO3 A;  2DVJ A;  3BUX B;  2H8H A;  1TZE E;  5EHR A;  4EIH A;  1O46 A;  3HCK A;  1AYB A;  1X6C A;  2IUG A;  1O4L A;  2DLY A;  5IBS A;  1LUM A;  2LNX A;  1KC2 A;  3EAZ A;  3IMD A;  3S8L A;  4P9Z A;  4E93 A;  1MIL A;  2EKX A;  1BM2 A;  3OVE A;  5HKZ A;  4A4C A;  1BG1 A;  2MC1 A;  3VS5 A;  4ROJ A;  2KK6 A;  1IJR A;  3IN7 A;  3GXW A;  1O47 A;  2LCT A;  4U1P A;  4FL3 A;  1LCK A;  2C9W A;  1LCJ A;  1BHF A;  1FBZ A;  1M27 A;  1O4F A;  1A07 A;  2PLD A;  1AYD A;  2DM0 A;  2VIF A;  2AUG A;  2AOB A;  1AOU F;  5DF6 A;  4JEG A;  4F5B A;  1A1C A;  1O4C A;  5EEL A;  3QWY A;  1GRI A;  3HHM B;  2CI9 A;  1BHH B;  2CRH A;  3OB2 B;  3TL0 A;  3LYV A;  1BMB A;  4GPL B;  2CS0 A;  3CWG A;  1O43 A;  2LNW A;  1TCE A;  3CBL A;  2HDX A;  2YU7 A;  4X6S A;  3VS1 A;  1O4R A;  2KGY A;  1SHD A;  2XP1 A;  2KNO A;  4XZ0 A;  3VRN A;  3TKZ A;  5I6V A;  1PIC A;  1WQU A;  4K45 A;  4P9V A;  1YVL A;  3EAC A;  1KSW A;  3OB1 B;  1FYR A;  3US4 A;  1OO3 A;  1AYC A;  2JYQ A;  1M61 A;  1LKL A;  1A08 A;  2MRJ A;  1SPS A;  2OZO A;  3CD3 A;  5HKW A;  5GJI A;  2OQ1 A;  3PSK A;  1JWO A;  2BBU A;  3VS2 A;  1SHA A;  3CXL A;  5J3X A;  4JGH A;  1CWD L;  1B47 A;  4NWF A;  1BFJ A;  1O45 A;  4GL9 E;  2L3T A;  1O4B A;  1QAD A;  3K2T A;  1R1Q A;  3N8M A;  1Y1U A;  3VS6 A;  1X0N A;  4GWF A;  2GE9 A;  3UF4 A;  1I3Z A;  1O4D A;  1SKJ A;  2Y1N A;  4K2R A;  1NRV A;  3KFJ A;  2HDV A;  2RVF A;  1A1E A;  1O4Q A;  3T04 A;  4K44 A;  4TZI A;  2RMX A;  1JYR A;  3IMJ A;  3ZNI A;  4H34 A;  2HCK A;  2K79 B;  2EL8 A;  2C0O A;  1O44 A;  2EYY A;  3M7F A;  5DC4 A;  2LQW A;  2DCR A;  1A81 A;  1A1A A;  2SRC A;  1MW4 A;  3N7Y A;  1FBV A;  1UUS A;  3K2M A;  5GJH A;  1FU6 A;  1Z3K A;  3VS0 A;  2B3O A;  2MRK A;  3VRO A;  1AB2 A;  1LUI A;  3PFV A;  2IUH A;  1O4G A;  2DX0 A;  4XZ1 A;  1O4M A;  1O4I A;  1NZL A;  1A09 A;  1O4E A;  3C7I A;  4OHL A;  2CR4 A;  1OPK A;  1R1P A;  2H5K A;  2PLE A;  2K7A B;  1O4O A;  2Y3A B;  2FO0 A;  3VS3 A;  1AYA A;  4F5A A;  1R1S A;  2CBL A;  1Y57 A;  2PNA A;  1BLK A;  2QMS A;  3MXY A;  2IZV A;  2FCI A;  1HCT B;  4NWG A;  5DC9 A;  2RSY A;  3VGO A;  4QSY A;  3IN8 A;  2ROR A;  3PJP A;  2MK2 A;  1D1Z A;  1RJA A;  1G83 A;  1SPR A;  1A1B A;  3VRQ A;  1CWE A;  2ABL A;  2ETZ A;  1BKL A;  1RPY A;  4K11 A;  4L1B B;  3VRY A;  2H46 E;  5EEQ A;  5KAZ A;  1BFI A;  1NZV A;  4H1O A;  1GHU A;  1F1W A;  1AD5 A;  1O42 A;  5EG3 B;  4LUD A;  2YSX A;  4OHI A;  4JE4 A;  5CDW A;  3PSJ A;  3NHN A;  3QWX X;  5D0J A;  1O4A A;  1H9O A;  1O4H A;  1F2F A;  4E68 A;  1BLJ A;  1CJ1 A;  1O4P A;  2PTK A;  1O49 A;  5BO4 A;  3S8O A;  3GXX A;  1XA6 A;  1IS0 A;  3S8N A;  4D8K A;  1O41 A;  4DGP A;  2HUW A;  1O48 A;  3VS4 A;  5AUL A;  1KA7 A;  1FU5 A;  1FHS A;  3MAZ A;  5EHP A;  3S9K A;  1LKK A;  1CSZ A;  1O4N A;  1ZFP E;  3BKB A;  4FBN A;  3BUM B;  2LQN A;  1JYQ A;  2L4K A;  3PS5 A;  4DGX A;  5HKY A;  3UYO A;  4OHH A;  2EYZ A;  3N84 A;  5AXI A;  2EO6 A;  1UUR A;  2EYV A;  3VRZ A;  1QG1 E;  3WA4 A;  2CI8 A;  2GSB A;  2SHP A;  3VS7 A;  4FL2 A;  4LUE A;  1JU5 A;  3MXC A;  2LRA A;  1X27 A;  4OHD A;  3BUN B;  4A4B A;  1D4T A;  1BHH A;  2C0T A;  3GQI B;  1D4W A;  3VRP A;  2ECD A;  3OP0 A;  1KA6 A;  2EOB A;  2MQI A;  3OV1 A;  2L6K A;  4M4Z A;  1FMK A;  1CSY A;  1LUN A;  1JYU A;  1P13 A;  2IUI A;  1K9A A;  3BUO B;  2DLZ A;  1BF5 A;  2AOA A;  5IBM A;  1BKM A;  3PLF B;  1LUK A;  2HMH A;  5DC0 B;  3VRR A;  3BUW B;  4WWQ A;  1AOT F;  1RQQ C;  2PNB A; 
#chains in the Genus database with same CATH homology
 3PQZ A;  1SHB A;  1HCS B;  2C0I A;  4OHE A;  4EY0 A;  2EU0 A;  1O4K A;  4U17 A;  4F59 A;  3HIZ B;  1YVH A;  2CIA A;  2Y1M A;  1OO4 A;  1O4J A;  1OPL A;  1QCF A;  2EO3 A;  2DVJ A;  3BUX B;  2H8H A;  1TZE E;  5EHR A;  4EIH A;  1O46 A;  3HCK A;  1AYB A;  1X6C A;  2IUG A;  1O4L A;  2DLY A;  5IBS A;  1LUM A;  2LNX A;  1KC2 A;  3EAZ A;  3IMD A;  3S8L A;  4P9Z A;  4E93 A;  1MIL A;  2EKX A;  1BM2 A;  3OVE A;  5HKZ A;  4A4C A;  1BG1 A;  2MC1 A;  3VS5 A;  4ROJ A;  2KK6 A;  1IJR A;  3IN7 A;  3GXW A;  1O47 A;  2LCT A;  4U1P A;  4FL3 A;  1LCK A;  2C9W A;  1LCJ A;  1BHF A;  1FBZ A;  1M27 A;  1O4F A;  1A07 A;  2PLD A;  1AYD A;  2DM0 A;  2VIF A;  2AUG A;  2AOB A;  1AOU F;  5DF6 A;  4JEG A;  4F5B A;  1A1C A;  1O4C A;  5EEL A;  3QWY A;  1GRI A;  3HHM B;  2CI9 A;  1BHH B;  2CRH A;  3OB2 B;  3TL0 A;  1BMB A;  4GPL B;  2CS0 A;  3CWG A;  1O43 A;  2LNW A;  1TCE A;  3CBL A;  2HDX A;  2YU7 A;  4X6S A;  3VS1 A;  1O4R A;  1SHD A;  2XP1 A;  2KNO A;  4XZ0 A;  3VRN A;  3TKZ A;  5I6V A;  1PIC A;  1WQU A;  4K45 A;  4P9V A;  1YVL A;  3EAC A;  1KSW A;  3OB1 B;  1FYR A;  3US4 A;  1OO3 A;  1AYC A;  2JYQ A;  1M61 A;  1LKL A;  1A08 A;  2MRJ A;  1SPS A;  2OZO A;  3CD3 A;  5HKW A;  5GJI A;  2OQ1 A;  3PSK A;  1JWO A;  2BBU A;  3VS2 A;  1SHA A;  3CXL A;  5J3X A;  4JGH A;  1CWD L;  1B47 A;  4NWF A;  1BFJ A;  1O45 A;  4GL9 E;  2L3T A;  1O4B A;  1QAD A;  1R1Q A;  3N8M A;  1Y1U A;  3VS6 A;  1X0N A;  4GWF A;  2GE9 A;  3UF4 A;  1I3Z A;  1O4D A;  1SKJ A;  2Y1N A;  4K2R A;  1NRV A;  3KFJ A;  2HDV A;  2RVF A;  1A1E A;  1O4Q A;  3T04 A;  4K44 A;  4TZI A;  2RMX A;  1JYR A;  3IMJ A;  3ZNI A;  4H34 A;  2HCK A;  2K79 B;  2EL8 A;  2C0O A;  1O44 A;  2EYY A;  3M7F A;  5DC4 A;  2LQW A;  2DCR A;  1A81 A;  1A1A A;  2SRC A;  1MW4 A;  3N7Y A;  1FBV A;  1UUS A;  3K2M A;  5GJH A;  1FU6 A;  1Z3K A;  3VS0 A;  2B3O A;  2MRK A;  3VRO A;  1AB2 A;  1LUI A;  3PFV A;  2IUH A;  1O4G A;  2DX0 A;  4XZ1 A;  1O4M A;  1O4I A;  1NZL A;  1A09 A;  1O4E A;  3C7I A;  4OHL A;  2CR4 A;  1OPK A;  1R1P A;  2H5K A;  2PLE A;  2K7A B;  1O4O A;  2Y3A B;  2FO0 A;  3VS3 A;  1AYA A;  4F5A A;  1R1S A;  2CBL A;  1Y57 A;  2PNA A;  1BLK A;  2QMS A;  3MXY A;  2IZV A;  2FCI A;  1HCT B;  4NWG A;  5DC9 A;  2RSY A;  3VGO A;  4QSY A;  3IN8 A;  2ROR A;  3PJP A;  2MK2 A;  1D1Z A;  1RJA A;  1G83 A;  1SPR A;  1A1B A;  3VRQ A;  1CWE A;  2ABL A;  2ETZ A;  1BKL A;  1RPY A;  4K11 A;  4L1B B;  3VRY A;  2H46 E;  5EEQ A;  5KAZ A;  1BFI A;  1NZV A;  4H1O A;  1GHU A;  1F1W A;  1AD5 A;  1O42 A;  5EG3 B;  4LUD A;  2YSX A;  4OHI A;  4JE4 A;  5CDW A;  3PSJ A;  3NHN A;  3QWX X;  5D0J A;  1O4A A;  1H9O A;  1O4H A;  1F2F A;  4E68 A;  1BLJ A;  1CJ1 A;  1O4P A;  2PTK A;  1O49 A;  5BO4 A;  3S8O A;  3GXX A;  1XA6 A;  1IS0 A;  3S8N A;  4D8K A;  1O41 A;  4DGP A;  2HUW A;  1O48 A;  3VS4 A;  5AUL A;  1KA7 A;  1FU5 A;  1FHS A;  3MAZ A;  5EHP A;  3S9K A;  1LKK A;  1CSZ A;  1O4N A;  1ZFP E;  3BKB A;  4FBN A;  3BUM B;  2LQN A;  1JYQ A;  2L4K A;  3PS5 A;  4DGX A;  5HKY A;  3UYO A;  4OHH A;  2EYZ A;  3N84 A;  5AXI A;  2EO6 A;  1UUR A;  2EYV A;  3VRZ A;  1QG1 E;  3WA4 A;  2CI8 A;  2GSB A;  2SHP A;  3VS7 A;  4FL2 A;  4LUE A;  1JU5 A;  3MXC A;  1X27 A;  4OHD A;  3BUN B;  4A4B A;  1D4T A;  1BHH A;  2C0T A;  3GQI B;  1D4W A;  3VRP A;  2ECD A;  3OP0 A;  1KA6 A;  2EOB A;  2MQI A;  3OV1 A;  2L6K A;  4M4Z A;  1FMK A;  1CSY A;  1LUN A;  1JYU A;  1P13 A;  2IUI A;  1K9A A;  3BUO B;  2DLZ A;  1BF5 A;  2AOA A;  5IBM A;  1BKM A;  3PLF B;  1LUK A;  2HMH A;  5DC0 B;  3VRR A;  3BUW B;  4WWQ A;  1AOT F;  1RQQ C;  2PNB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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