3N84A

Crystal structure of the grb2 sh2 domain in complex with a 23-membered macrocyclic ligand having the sequence pyvnvp
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
109
structure length
109
Chain Sequence
MKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions.
pubmed doi rcsb
molecule tags Protein binding/peptide
source organism Homo sapiens
molecule keywords Growth factor receptor-bound protein 2
total genus 27
structure length 109
sequence length 109
chains with identical sequence B, C, D, E, F
ec nomenclature
pdb deposition date 2010-05-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00017 SH2 SH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 3n84A00
2AOAA 2C0OA 2EU0A 1RQQC 4FL2A 4JGHA 2ABLA 2H5KA 4OHHA 1JYQA 2PLDA 1SKJA 1AYDA 2CS0A 4FL3A 3VS7A 3VS5A 4ROJA 3N7YA 2LCTA 1M61A 4P9VA 2GE9A 1A08A 1KC2A 1X6CA 4F5AA 2B3OA 3ZNIA 1QADA 1CJ1A 4U1PA 1O4LA 2KK6A 3UF4A 4K11A 2SHPA 5BO4A 3QWYA 1X0NA 1K9AA 3HIZB 3IMDA 1LCJA 1BHHB 1O4PA 4M4ZA 2IUGA 2EO3A 3MXCA 4X6SA 5DC4A 3VS0A 1H9OA 2L6KA 4OHEA 2OZOA 1AOUF 3HCKA 2K79B 4D8KA 2L4KA 5IBMA 1R1PA 1BLJA 2EYVA 1O4GA 1BF5A 1JYRA 1O4NA 1YVHA 1NRVA 4DGPA 3UYOA 2CI9A 1O46A 2EKXA 2QMSA 3EAZA 1O4QA 3VRNA 1MW4A 2LNWA 2OQ1A 2Y1MA 3BUWB 1AYBA 1NZLA 2KNOA 1D4WA 2HMHA 5DC0B 5DF6A 1O4IA 1I3ZA 1KA7A 3VS4A 1Z3KA 5AXIA 4F5BA 3CXLA 2ETZA 2HUWA 2DM0A 5D0JA 1FMKA 2H46E 3VRYA 5AULA 5I6VA 2CRHA 3VRQA 1A09A 1O4OA 3IN7A 2C0TA 1KA6A 2H8HA 2DCRA 1FHSA 1O43A 3NHNA 1QCFA 2MK2A 1FU6A 1R1QA 4OHIA 2CR4A 3BKBA 2L3TA 1BHFA 1AD5A 1SPRA 1FBVA 1LKLA 4NWGA 2JYQA 2YSXA 1UUSA 2EYYA 2GSBA 1FU5A 5EG3B 1BHHA 1O4EA 3N84A 5CDWA 2RVFA 4K45A 1O4DA 2PNBA 1JYUA 5EHRA 3OB1B 2C9WA 1O44A 3IN8A 4XZ0A 1LKKA 1OPLA 2MRKA 1A1EA 4JEGA 2K7AB 1O4MA 1LUIA 1AOTF 2MC1A 1CWEA 5IBSA 2IUIA 3PFVA 4WWQA 4F59A 1NZVA 1BFIA 1O42A 3VS1A 1BLKA 4L1BB 1YVLA 1QG1E 4U17A 4K44A 3IMJA 1CWDL 2RMXA 3S9KA 2MQIA 1OO4A 1Y57A 2PLEA 3WA4A 1CSYA 1OPKA 1A1CA 1Y1UA 1F2FA 3MAZA 1O45A 2AOBA 1LUKA 4TZIA 1SHBA 3OB2B 3GXWA 4XZ1A 1A1BA 4EIHA 3PSKA 4JE4A 4GWFA 1B47A 1BKLA 2LQWA 1O48A 1LUNA 2DLZA 3EACA 1O4AA 4NWFA 3QWXX 1BMBA 4K2RA 4H1OA 3S8NA 2VIFA 2DVJA 3PS5A 1O49A 2CIAA 5GJIA 4QSYA 3HHMB 3PQZA 1AB2A 3VS3A 1IJRA 2PTKA 3VGOA 1JU5A 4OHDA 1FBZA 1FYRA 1HCTB 2YU7A 3C7IA 1XA6A 5EELA 4A4CA 2PNAA 4P9ZA 2BBUA 1P13A 2Y3AB 4A4BA 2CBLA 3VS2A 1LCKA 1JWOA 2IZVA 3VRZA 1HCSB 1O41A 1CSZA 1M27A 4GL9E 1BFJA 5KAZA 2SRCA 1ZFPE 3VRPA 3PSJA 3BUMB 3M7FA 1O4HA 1G83A 2C0IA 1A1AA 1OO3A 3S8OA 1SHAA 2DX0A 3TKZA 2EO6A 2HDVA 1BM2A 2Y1NA 1MILA 2AUGA 1AYAA 2RSYA 3CWGA 5HKZA 4LUEA 1O4FA 3KFJA 3PJPA 2ECDA 1D1ZA 3OP0A 5DC9A 2IUHA 3TL0A 4LUDA 5EEQA 2EOBA 1UURA 4OHLA 3VROA 3GQIB 2EL8A 1O4KA 3US4A 3OV1A 1LUMA 5EHPA 2LNXA 1F1WA 5HKWA 1SHDA 4EY0A 1D4TA 1O47A 5HKYA 2DLYA 5J3XA 5GJHA 1RJAA 2LQNA 1O4RA 3CD3A 3VRRA 3K2MA 1O4CA 1A07A 2EYZA 1WQUA 1A81A 3N8MA 1SPSA 3MXYA 1X27A 1O4BA 2MRJA 1O4JA 1KSWA 3GXXA 1GRIA 3T04A 3S8LA 3OVEA 2CI8A 3CBLA 3BUNB 1IS0A 2HDXA 2HCKA 3VS6A 1TCEA 4E93A 4H34A 2FO0A 4E68A 1GHUA 4DGXA 1TZEE 3BUXB 1BG1A 2FCIA 4GPLB 1RPYA 3BUOB 1AYCA 1PICA 4FBNA 2RORA 2XP1A 1BKMA 1R1SA 3PLFB
chains in the Genus database with same CATH superfamily
2AOAA 2C0OA 2EU0A 1RQQC 4FL2A 4JGHA 2KGYA 2ABLA 2H5KA 4OHHA 1JYQA 2PLDA 1SKJA 1AYDA 2CS0A 4FL3A 3VS7A 3VS5A 4ROJA 3N7YA 2LCTA 1M61A 4P9VA 2GE9A 1A08A 1KC2A 1X6CA 4F5AA 2B3OA 3ZNIA 1QADA 1CJ1A 4U1PA 1O4LA 2KK6A 3UF4A 4K11A 2SHPA 5BO4A 3QWYA 1X0NA 1K9AA 3HIZB 3IMDA 1LCJA 1BHHB 1O4PA 4M4ZA 2IUGA 2EO3A 3MXCA 4X6SA 5DC4A 3VS0A 1H9OA 2L6KA 4OHEA 2OZOA 1AOUF 3HCKA 2K79B 4D8KA 2L4KA 5IBMA 1R1PA 1BLJA 2EYVA 1O4GA 1BF5A 1JYRA 1O4NA 1YVHA 1NRVA 4DGPA 3UYOA 2CI9A 1O46A 2EKXA 2QMSA 3EAZA 1O4QA 3VRNA 1MW4A 2LNWA 2OQ1A 2Y1MA 3BUWB 1AYBA 1NZLA 2KNOA 1D4WA 2HMHA 5DC0B 5DF6A 1O4IA 1I3ZA 1KA7A 3VS4A 1Z3KA 5AXIA 4F5BA 3CXLA 2ETZA 2HUWA 2DM0A 5D0JA 1FMKA 2H46E 3VRYA 5AULA 5I6VA 2CRHA 3VRQA 1A09A 1O4OA 3IN7A 2C0TA 1KA6A 2H8HA 2DCRA 1FHSA 1O43A 3NHNA 1QCFA 2MK2A 1FU6A 1R1QA 4OHIA 2CR4A 3BKBA 2L3TA 1BHFA 1AD5A 1SPRA 1FBVA 1LKLA 4NWGA 2JYQA 2YSXA 1UUSA 2EYYA 2GSBA 1FU5A 5EG3B 1BHHA 1O4EA 3N84A 5CDWA 2RVFA 4K45A 1O4DA 2PNBA 1JYUA 5EHRA 3OB1B 2C9WA 1O44A 3IN8A 4XZ0A 1LKKA 1OPLA 2MRKA 1A1EA 4JEGA 2K7AB 1O4MA 1LUIA 1AOTF 2MC1A 1CWEA 5IBSA 2IUIA 3PFVA 4WWQA 4F59A 1NZVA 1BFIA 1O42A 3VS1A 1BLKA 4L1BB 1YVLA 1QG1E 4U17A 4K44A 3IMJA 1CWDL 2RMXA 3S9KA 2MQIA 1OO4A 1Y57A 2PLEA 3WA4A 1CSYA 1OPKA 1A1CA 1Y1UA 1F2FA 3MAZA 1O45A 2AOBA 1LUKA 4TZIA 1SHBA 3OB2B 3GXWA 4XZ1A 1A1BA 4EIHA 3PSKA 4JE4A 4GWFA 2LRAA 1B47A 1BKLA 2LQWA 1O48A 1LUNA 2DLZA 3EACA 1O4AA 4NWFA 3QWXX 1BMBA 4K2RA 3K2TA 4H1OA 3S8NA 2VIFA 2DVJA 3PS5A 1O49A 2CIAA 5GJIA 4QSYA 3HHMB 3PQZA 1AB2A 3VS3A 1IJRA 2PTKA 3VGOA 1JU5A 4OHDA 1FBZA 1FYRA 1HCTB 2YU7A 3C7IA 1XA6A 5EELA 4A4CA 2PNAA 4P9ZA 2BBUA 1P13A 2Y3AB 4A4BA 3LYVA 2CBLA 3VS2A 1LCKA 1JWOA 2IZVA 3VRZA 1HCSB 1O41A 1CSZA 1M27A 4GL9E 1BFJA 5KAZA 2SRCA 1ZFPE 3VRPA 3PSJA 3BUMB 3M7FA 1O4HA 1G83A 2C0IA 1A1AA 1OO3A 3S8OA 1SHAA 2DX0A 3TKZA 2EO6A 2HDVA 1BM2A 2Y1NA 1MILA 2AUGA 1AYAA 2RSYA 3CWGA 5HKZA 4LUEA 1O4FA 3KFJA 3PJPA 2ECDA 1D1ZA 3OP0A 5DC9A 2IUHA 3TL0A 4LUDA 5EEQA 2EOBA 1UURA 4OHLA 3VROA 3GQIB 2EL8A 1O4KA 3US4A 3OV1A 1LUMA 5EHPA 2LNXA 1F1WA 5HKWA 1SHDA 4EY0A 1D4TA 1O47A 5HKYA 2DLYA 5J3XA 5GJHA 1RJAA 2LQNA 1O4RA 3CD3A 3VRRA 3K2MA 1O4CA 1A07A 2EYZA 1WQUA 1A81A 3N8MA 1SPSA 3MXYA 1X27A 1O4BA 2MRJA 1O4JA 1KSWA 3GXXA 1GRIA 3T04A 3S8LA 3OVEA 2CI8A 3CBLA 3BUNB 1IS0A 2HDXA 2HCKA 3VS6A 1TCEA 4E93A 4H34A 2FO0A 4E68A 1GHUA 4DGXA 1TZEE 3BUXB 1BG1A 2FCIA 4GPLB 1RPYA 3BUOB 1AYCA 1PICA 4FBNA 2RORA 2XP1A 1BKMA 1R1SA 3PLFB
chains in the Genus database with same CATH topology
2AOAA 2C0OA 2EU0A 1RQQC 4FL2A 4JGHA 2ABLA 2H5KA 4OHHA 1JYQA 2PLDA 1SKJA 1AYDA 2CS0A 4FL3A 3VS7A 3VS5A 4ROJA 3N7YA 2LCTA 1M61A 4P9VA 2GE9A 1A08A 1KC2A 1X6CA 4F5AA 2B3OA 3ZNIA 1QADA 1CJ1A 4U1PA 1O4LA 2KK6A 3UF4A 4K11A 2SHPA 5BO4A 3QWYA 1X0NA 1K9AA 3HIZB 3IMDA 1LCJA 1BHHB 1O4PA 4M4ZA 2IUGA 2EO3A 3MXCA 4X6SA 5DC4A 3VS0A 1H9OA 2L6KA 4OHEA 2OZOA 1AOUF 3HCKA 2K79B 4D8KA 2L4KA 5IBMA 1R1PA 1BLJA 2EYVA 1O4GA 1BF5A 1JYRA 1O4NA 1YVHA 1NRVA 4DGPA 3UYOA 2CI9A 1O46A 2EKXA 2QMSA 3EAZA 1O4QA 3VRNA 1MW4A 2LNWA 2OQ1A 2Y1MA 3BUWB 1AYBA 1NZLA 2KNOA 1D4WA 2HMHA 5DC0B 5DF6A 1O4IA 1I3ZA 1KA7A 3VS4A 1Z3KA 5AXIA 4F5BA 3CXLA 2ETZA 2HUWA 2DM0A 5D0JA 1FMKA 2H46E 3VRYA 5AULA 5I6VA 2CRHA 3VRQA 1A09A 1O4OA 3IN7A 2C0TA 1KA6A 2H8HA 2DCRA 1FHSA 1O43A 3NHNA 1QCFA 2MK2A 1FU6A 1R1QA 4OHIA 2CR4A 3BKBA 2L3TA 1BHFA 1AD5A 1SPRA 1FBVA 1LKLA 4NWGA 2JYQA 2YSXA 1UUSA 2EYYA 2GSBA 1FU5A 5EG3B 1BHHA 1O4EA 3N84A 5CDWA 2RVFA 4K45A 1O4DA 2PNBA 1JYUA 5EHRA 3OB1B 2C9WA 1O44A 3IN8A 4XZ0A 1LKKA 1OPLA 2MRKA 1A1EA 4JEGA 2K7AB 1O4MA 1LUIA 1AOTF 2MC1A 1CWEA 5IBSA 2IUIA 3PFVA 4WWQA 4F59A 1NZVA 1BFIA 1O42A 3VS1A 1BLKA 4L1BB 1YVLA 1QG1E 4U17A 4K44A 3IMJA 1CWDL 2RMXA 3S9KA 2MQIA 1OO4A 1Y57A 2PLEA 3WA4A 1CSYA 1OPKA 1A1CA 1Y1UA 1F2FA 3MAZA 1O45A 2AOBA 1LUKA 4TZIA 1SHBA 3OB2B 3GXWA 4XZ1A 1A1BA 4EIHA 3PSKA 4JE4A 4GWFA 1B47A 1BKLA 2LQWA 1O48A 1LUNA 2DLZA 3EACA 1O4AA 4NWFA 3QWXX 1BMBA 4K2RA 4H1OA 3S8NA 2VIFA 2DVJA 3PS5A 1O49A 2CIAA 5GJIA 4QSYA 3HHMB 3PQZA 1AB2A 3VS3A 1IJRA 2PTKA 3VGOA 1JU5A 4OHDA 1FBZA 1FYRA 1HCTB 2YU7A 3C7IA 1XA6A 5EELA 4A4CA 2PNAA 4P9ZA 2BBUA 1P13A 2Y3AB 4A4BA 2CBLA 3VS2A 1LCKA 1JWOA 2IZVA 3VRZA 1HCSB 1O41A 1CSZA 1M27A 4GL9E 1BFJA 5KAZA 2SRCA 1ZFPE 3VRPA 3PSJA 3BUMB 3M7FA 1O4HA 1G83A 2C0IA 1A1AA 1OO3A 3S8OA 1SHAA 2DX0A 3TKZA 2EO6A 2HDVA 1BM2A 2Y1NA 1MILA 2AUGA 1AYAA 2RSYA 3CWGA 5HKZA 4LUEA 1O4FA 3KFJA 3PJPA 2ECDA 1D1ZA 3OP0A 5DC9A 2IUHA 3TL0A 4LUDA 5EEQA 2EOBA 1UURA 4OHLA 3VROA 3GQIB 2EL8A 1O4KA 3US4A 3OV1A 1LUMA 5EHPA 2LNXA 1F1WA 5HKWA 1SHDA 4EY0A 1D4TA 1O47A 5HKYA 2DLYA 5J3XA 5GJHA 1RJAA 2LQNA 1O4RA 3CD3A 3VRRA 3K2MA 1O4CA 1A07A 2EYZA 1WQUA 1A81A 3N8MA 1SPSA 3MXYA 1X27A 1O4BA 2MRJA 1O4JA 1KSWA 3GXXA 1GRIA 3T04A 3S8LA 3OVEA 2CI8A 3CBLA 3BUNB 1IS0A 2HDXA 2HCKA 3VS6A 1TCEA 4E93A 4H34A 2FO0A 4E68A 1GHUA 4DGXA 1TZEE 3BUXB 1BG1A 2FCIA 4GPLB 1RPYA 3BUOB 1AYCA 1PICA 4FBNA 2RORA 2XP1A 1BKMA 1R1SA 3PLFB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2AOA A;  2C0O A;  2EU0 A;  1RQQ C;  4FL2 A;  4JGH A;  2ABL A;  2H5K A;  4OHH A;  1JYQ A;  2PLD A;  1SKJ A;  1AYD A;  2CS0 A;  4FL3 A;  3VS7 A;  3VS5 A;  4ROJ A;  3N7Y A;  2LCT A;  1M61 A;  4P9V A;  2GE9 A;  1A08 A;  1KC2 A;  1X6C A;  4F5A A;  2B3O A;  3ZNI A;  1QAD A;  1CJ1 A;  4U1P A;  1O4L A;  2KK6 A;  3UF4 A;  4K11 A;  2SHP A;  5BO4 A;  3QWY A;  1X0N A;  1K9A A;  3HIZ B;  3IMD A;  1LCJ A;  1BHH B;  1O4P A;  4M4Z A;  2IUG A;  2EO3 A;  3MXC A;  4X6S A;  5DC4 A;  3VS0 A;  1H9O A;  2L6K A;  4OHE A;  2OZO A;  1AOU F;  3HCK A;  2K79 B;  4D8K A;  2L4K A;  5IBM A;  1R1P A;  1BLJ A;  2EYV A;  1O4G A;  1BF5 A;  1JYR A;  1O4N A;  1YVH A;  1NRV A;  4DGP A;  3UYO A;  2CI9 A;  1O46 A;  2EKX A;  2QMS A;  3EAZ A;  1O4Q A;  3VRN A;  1MW4 A;  2LNW A;  2OQ1 A;  2Y1M A;  3BUW B;  1AYB A;  1NZL A;  2KNO A;  1D4W A;  2HMH A;  5DC0 B;  5DF6 A;  1O4I A;  1I3Z A;  1KA7 A;  3VS4 A;  1Z3K A;  5AXI A;  4F5B A;  3CXL A;  2ETZ A;  2HUW A;  2DM0 A;  5D0J A;  1FMK A;  2H46 E;  3VRY A;  5AUL A;  5I6V A;  2CRH A;  3VRQ A;  1A09 A;  1O4O A;  3IN7 A;  2C0T A;  1KA6 A;  2H8H A;  2DCR A;  1FHS A;  1O43 A;  3NHN A;  1QCF A;  2MK2 A;  1FU6 A;  1R1Q A;  4OHI A;  2CR4 A;  3BKB A;  2L3T A;  1BHF A;  1AD5 A;  1SPR A;  1FBV A;  1LKL A;  4NWG A;  2JYQ A;  2YSX A;  1UUS A;  2EYY A;  2GSB A;  1FU5 A;  5EG3 B;  1BHH A;  1O4E A;  3N84 A;  5CDW A;  2RVF A;  4K45 A;  1O4D A;  2PNB A;  1JYU A;  5EHR A;  3OB1 B;  2C9W A;  1O44 A;  3IN8 A;  4XZ0 A;  1LKK A;  1OPL A;  2MRK A;  1A1E A;  4JEG A;  2K7A B;  1O4M A;  1LUI A;  1AOT F;  2MC1 A;  1CWE A;  5IBS A;  2IUI A;  3PFV A;  4WWQ A;  4F59 A;  1NZV A;  1BFI A;  1O42 A;  3VS1 A;  1BLK A;  4L1B B;  1YVL A;  1QG1 E;  4U17 A;  4K44 A;  3IMJ A;  1CWD L;  2RMX A;  3S9K A;  2MQI A;  1OO4 A;  1Y57 A;  2PLE A;  3WA4 A;  1CSY A;  1OPK A;  1A1C A;  1Y1U A;  1F2F A;  3MAZ A;  1O45 A;  2AOB A;  1LUK A;  4TZI A;  1SHB A;  3OB2 B;  3GXW A;  4XZ1 A;  1A1B A;  4EIH A;  3PSK A;  4JE4 A;  4GWF A;  1B47 A;  1BKL A;  2LQW A;  1O48 A;  1LUN A;  2DLZ A;  3EAC A;  1O4A A;  4NWF A;  3QWX X;  1BMB A;  4K2R A;  4H1O A;  3S8N A;  2VIF A;  2DVJ A;  3PS5 A;  1O49 A;  2CIA A;  5GJI A;  4QSY A;  3HHM B;  3PQZ A;  1AB2 A;  3VS3 A;  1IJR A;  2PTK A;  3VGO A;  1JU5 A;  4OHD A;  1FBZ A;  1FYR A;  1HCT B;  2YU7 A;  3C7I A;  1XA6 A;  5EEL A;  4A4C A;  2PNA A;  4P9Z A;  2BBU A;  1P13 A;  2Y3A B;  4A4B A;  2CBL A;  3VS2 A;  1LCK A;  1JWO A;  2IZV A;  3VRZ A;  1HCS B;  1O41 A;  1CSZ A;  1M27 A;  4GL9 E;  1BFJ A;  5KAZ A;  2SRC A;  1ZFP E;  3VRP A;  3PSJ A;  3BUM B;  3M7F A;  1O4H A;  1G83 A;  2C0I A;  1A1A A;  1OO3 A;  3S8O A;  1SHA A;  2DX0 A;  3TKZ A;  2EO6 A;  2HDV A;  1BM2 A;  2Y1N A;  1MIL A;  2AUG A;  1AYA A;  2RSY A;  3CWG A;  5HKZ A;  4LUE A;  1O4F A;  3KFJ A;  3PJP A;  2ECD A;  1D1Z A;  3OP0 A;  5DC9 A;  2IUH A;  3TL0 A;  4LUD A;  5EEQ A;  2EOB A;  1UUR A;  4OHL A;  3VRO A;  3GQI B;  2EL8 A;  1O4K A;  3US4 A;  3OV1 A;  1LUM A;  5EHP A;  2LNX A;  1F1W A;  5HKW A;  1SHD A;  4EY0 A;  1D4T A;  1O47 A;  5HKY A;  2DLY A;  5J3X A;  5GJH A;  1RJA A;  2LQN A;  1O4R A;  3CD3 A;  3VRR A;  3K2M A;  1O4C A;  1A07 A;  2EYZ A;  1WQU A;  1A81 A;  3N8M A;  1SPS A;  3MXY A;  1X27 A;  1O4B A;  2MRJ A;  1O4J A;  1KSW A;  3GXX A;  1GRI A;  3T04 A;  3S8L A;  3OVE A;  2CI8 A;  3CBL A;  3BUN B;  1IS0 A;  2HDX A;  2HCK A;  3VS6 A;  1TCE A;  4E93 A;  4H34 A;  2FO0 A;  4E68 A;  1GHU A;  4DGX A;  1TZE E;  3BUX B;  1BG1 A;  2FCI A;  4GPL B;  1RPY A;  3BUO B;  1AYC A;  1PIC A;  4FBN A;  2ROR A;  2XP1 A;  1BKM A;  1R1S A;  3PLF B; 
#chains in the Genus database with same CATH topology
 2AOA A;  2C0O A;  2EU0 A;  1RQQ C;  4FL2 A;  4JGH A;  2KGY A;  2ABL A;  2H5K A;  4OHH A;  1JYQ A;  2PLD A;  1SKJ A;  1AYD A;  2CS0 A;  4FL3 A;  3VS7 A;  3VS5 A;  4ROJ A;  3N7Y A;  2LCT A;  1M61 A;  4P9V A;  2GE9 A;  1A08 A;  1KC2 A;  1X6C A;  4F5A A;  2B3O A;  3ZNI A;  1QAD A;  1CJ1 A;  4U1P A;  1O4L A;  2KK6 A;  3UF4 A;  4K11 A;  2SHP A;  5BO4 A;  3QWY A;  1X0N A;  1K9A A;  3HIZ B;  3IMD A;  1LCJ A;  1BHH B;  1O4P A;  4M4Z A;  2IUG A;  2EO3 A;  3MXC A;  4X6S A;  5DC4 A;  3VS0 A;  1H9O A;  2L6K A;  4OHE A;  2OZO A;  1AOU F;  3HCK A;  2K79 B;  4D8K A;  2L4K A;  5IBM A;  1R1P A;  1BLJ A;  2EYV A;  1O4G A;  1BF5 A;  1JYR A;  1O4N A;  1YVH A;  1NRV A;  4DGP A;  3UYO A;  2CI9 A;  1O46 A;  2EKX A;  2QMS A;  3EAZ A;  1O4Q A;  3VRN A;  1MW4 A;  2LNW A;  2OQ1 A;  2Y1M A;  3BUW B;  1AYB A;  1NZL A;  2KNO A;  1D4W A;  2HMH A;  5DC0 B;  5DF6 A;  1O4I A;  1I3Z A;  1KA7 A;  3VS4 A;  1Z3K A;  5AXI A;  4F5B A;  3CXL A;  2ETZ A;  2HUW A;  2DM0 A;  5D0J A;  1FMK A;  2H46 E;  3VRY A;  5AUL A;  5I6V A;  2CRH A;  3VRQ A;  1A09 A;  1O4O A;  3IN7 A;  2C0T A;  1KA6 A;  2H8H A;  2DCR A;  1FHS A;  1O43 A;  3NHN A;  1QCF A;  2MK2 A;  1FU6 A;  1R1Q A;  4OHI A;  2CR4 A;  3BKB A;  2L3T A;  1BHF A;  1AD5 A;  1SPR A;  1FBV A;  1LKL A;  4NWG A;  2JYQ A;  2YSX A;  1UUS A;  2EYY A;  2GSB A;  1FU5 A;  5EG3 B;  1BHH A;  1O4E A;  3N84 A;  5CDW A;  2RVF A;  4K45 A;  1O4D A;  2PNB A;  1JYU A;  5EHR A;  3OB1 B;  2C9W A;  1O44 A;  3IN8 A;  4XZ0 A;  1LKK A;  1OPL A;  2MRK A;  1A1E A;  4JEG A;  2K7A B;  1O4M A;  1LUI A;  1AOT F;  2MC1 A;  1CWE A;  5IBS A;  2IUI A;  3PFV A;  4WWQ A;  4F59 A;  1NZV A;  1BFI A;  1O42 A;  3VS1 A;  1BLK A;  4L1B B;  1YVL A;  1QG1 E;  4U17 A;  4K44 A;  3IMJ A;  1CWD L;  2RMX A;  3S9K A;  2MQI A;  1OO4 A;  1Y57 A;  2PLE A;  3WA4 A;  1CSY A;  1OPK A;  1A1C A;  1Y1U A;  1F2F A;  3MAZ A;  1O45 A;  2AOB A;  1LUK A;  4TZI A;  1SHB A;  3OB2 B;  3GXW A;  4XZ1 A;  1A1B A;  4EIH A;  3PSK A;  4JE4 A;  4GWF A;  2LRA A;  1B47 A;  1BKL A;  2LQW A;  1O48 A;  1LUN A;  2DLZ A;  3EAC A;  1O4A A;  4NWF A;  3QWX X;  1BMB A;  4K2R A;  3K2T A;  4H1O A;  3S8N A;  2VIF A;  2DVJ A;  3PS5 A;  1O49 A;  2CIA A;  5GJI A;  4QSY A;  3HHM B;  3PQZ A;  1AB2 A;  3VS3 A;  1IJR A;  2PTK A;  3VGO A;  1JU5 A;  4OHD A;  1FBZ A;  1FYR A;  1HCT B;  2YU7 A;  3C7I A;  1XA6 A;  5EEL A;  4A4C A;  2PNA A;  4P9Z A;  2BBU A;  1P13 A;  2Y3A B;  4A4B A;  3LYV A;  2CBL A;  3VS2 A;  1LCK A;  1JWO A;  2IZV A;  3VRZ A;  1HCS B;  1O41 A;  1CSZ A;  1M27 A;  4GL9 E;  1BFJ A;  5KAZ A;  2SRC A;  1ZFP E;  3VRP A;  3PSJ A;  3BUM B;  3M7F A;  1O4H A;  1G83 A;  2C0I A;  1A1A A;  1OO3 A;  3S8O A;  1SHA A;  2DX0 A;  3TKZ A;  2EO6 A;  2HDV A;  1BM2 A;  2Y1N A;  1MIL A;  2AUG A;  1AYA A;  2RSY A;  3CWG A;  5HKZ A;  4LUE A;  1O4F A;  3KFJ A;  3PJP A;  2ECD A;  1D1Z A;  3OP0 A;  5DC9 A;  2IUH A;  3TL0 A;  4LUD A;  5EEQ A;  2EOB A;  1UUR A;  4OHL A;  3VRO A;  3GQI B;  2EL8 A;  1O4K A;  3US4 A;  3OV1 A;  1LUM A;  5EHP A;  2LNX A;  1F1W A;  5HKW A;  1SHD A;  4EY0 A;  1D4T A;  1O47 A;  5HKY A;  2DLY A;  5J3X A;  5GJH A;  1RJA A;  2LQN A;  1O4R A;  3CD3 A;  3VRR A;  3K2M A;  1O4C A;  1A07 A;  2EYZ A;  1WQU A;  1A81 A;  3N8M A;  1SPS A;  3MXY A;  1X27 A;  1O4B A;  2MRJ A;  1O4J A;  1KSW A;  3GXX A;  1GRI A;  3T04 A;  3S8L A;  3OVE A;  2CI8 A;  3CBL A;  3BUN B;  1IS0 A;  2HDX A;  2HCK A;  3VS6 A;  1TCE A;  4E93 A;  4H34 A;  2FO0 A;  4E68 A;  1GHU A;  4DGX A;  1TZE E;  3BUX B;  1BG1 A;  2FCI A;  4GPL B;  1RPY A;  3BUO B;  1AYC A;  1PIC A;  4FBN A;  2ROR A;  2XP1 A;  1BKM A;  1R1S A;  3PLF B; 
#chains in the Genus database with same CATH homology
 2AOA A;  2C0O A;  2EU0 A;  1RQQ C;  4FL2 A;  4JGH A;  2ABL A;  2H5K A;  4OHH A;  1JYQ A;  2PLD A;  1SKJ A;  1AYD A;  2CS0 A;  4FL3 A;  3VS7 A;  3VS5 A;  4ROJ A;  3N7Y A;  2LCT A;  1M61 A;  4P9V A;  2GE9 A;  1A08 A;  1KC2 A;  1X6C A;  4F5A A;  2B3O A;  3ZNI A;  1QAD A;  1CJ1 A;  4U1P A;  1O4L A;  2KK6 A;  3UF4 A;  4K11 A;  2SHP A;  5BO4 A;  3QWY A;  1X0N A;  1K9A A;  3HIZ B;  3IMD A;  1LCJ A;  1BHH B;  1O4P A;  4M4Z A;  2IUG A;  2EO3 A;  3MXC A;  4X6S A;  5DC4 A;  3VS0 A;  1H9O A;  2L6K A;  4OHE A;  2OZO A;  1AOU F;  3HCK A;  2K79 B;  4D8K A;  2L4K A;  5IBM A;  1R1P A;  1BLJ A;  2EYV A;  1O4G A;  1BF5 A;  1JYR A;  1O4N A;  1YVH A;  1NRV A;  4DGP A;  3UYO A;  2CI9 A;  1O46 A;  2EKX A;  2QMS A;  3EAZ A;  1O4Q A;  3VRN A;  1MW4 A;  2LNW A;  2OQ1 A;  2Y1M A;  3BUW B;  1AYB A;  1NZL A;  2KNO A;  1D4W A;  2HMH A;  5DC0 B;  5DF6 A;  1O4I A;  1I3Z A;  1KA7 A;  3VS4 A;  1Z3K A;  5AXI A;  4F5B A;  3CXL A;  2ETZ A;  2HUW A;  2DM0 A;  5D0J A;  1FMK A;  2H46 E;  3VRY A;  5AUL A;  5I6V A;  2CRH A;  3VRQ A;  1A09 A;  1O4O A;  3IN7 A;  2C0T A;  1KA6 A;  2H8H A;  2DCR A;  1FHS A;  1O43 A;  3NHN A;  1QCF A;  2MK2 A;  1FU6 A;  1R1Q A;  4OHI A;  2CR4 A;  3BKB A;  2L3T A;  1BHF A;  1AD5 A;  1SPR A;  1FBV A;  1LKL A;  4NWG A;  2JYQ A;  2YSX A;  1UUS A;  2EYY A;  2GSB A;  1FU5 A;  5EG3 B;  1BHH A;  1O4E A;  3N84 A;  5CDW A;  2RVF A;  4K45 A;  1O4D A;  2PNB A;  1JYU A;  5EHR A;  3OB1 B;  2C9W A;  1O44 A;  3IN8 A;  4XZ0 A;  1LKK A;  1OPL A;  2MRK A;  1A1E A;  4JEG A;  2K7A B;  1O4M A;  1LUI A;  1AOT F;  2MC1 A;  1CWE A;  5IBS A;  2IUI A;  3PFV A;  4WWQ A;  4F59 A;  1NZV A;  1BFI A;  1O42 A;  3VS1 A;  1BLK A;  4L1B B;  1YVL A;  1QG1 E;  4U17 A;  4K44 A;  3IMJ A;  1CWD L;  2RMX A;  3S9K A;  2MQI A;  1OO4 A;  1Y57 A;  2PLE A;  3WA4 A;  1CSY A;  1OPK A;  1A1C A;  1Y1U A;  1F2F A;  3MAZ A;  1O45 A;  2AOB A;  1LUK A;  4TZI A;  1SHB A;  3OB2 B;  3GXW A;  4XZ1 A;  1A1B A;  4EIH A;  3PSK A;  4JE4 A;  4GWF A;  1B47 A;  1BKL A;  2LQW A;  1O48 A;  1LUN A;  2DLZ A;  3EAC A;  1O4A A;  4NWF A;  3QWX X;  1BMB A;  4K2R A;  4H1O A;  3S8N A;  2VIF A;  2DVJ A;  3PS5 A;  1O49 A;  2CIA A;  5GJI A;  4QSY A;  3HHM B;  3PQZ A;  1AB2 A;  3VS3 A;  1IJR A;  2PTK A;  3VGO A;  1JU5 A;  4OHD A;  1FBZ A;  1FYR A;  1HCT B;  2YU7 A;  3C7I A;  1XA6 A;  5EEL A;  4A4C A;  2PNA A;  4P9Z A;  2BBU A;  1P13 A;  2Y3A B;  4A4B A;  2CBL A;  3VS2 A;  1LCK A;  1JWO A;  2IZV A;  3VRZ A;  1HCS B;  1O41 A;  1CSZ A;  1M27 A;  4GL9 E;  1BFJ A;  5KAZ A;  2SRC A;  1ZFP E;  3VRP A;  3PSJ A;  3BUM B;  3M7F A;  1O4H A;  1G83 A;  2C0I A;  1A1A A;  1OO3 A;  3S8O A;  1SHA A;  2DX0 A;  3TKZ A;  2EO6 A;  2HDV A;  1BM2 A;  2Y1N A;  1MIL A;  2AUG A;  1AYA A;  2RSY A;  3CWG A;  5HKZ A;  4LUE A;  1O4F A;  3KFJ A;  3PJP A;  2ECD A;  1D1Z A;  3OP0 A;  5DC9 A;  2IUH A;  3TL0 A;  4LUD A;  5EEQ A;  2EOB A;  1UUR A;  4OHL A;  3VRO A;  3GQI B;  2EL8 A;  1O4K A;  3US4 A;  3OV1 A;  1LUM A;  5EHP A;  2LNX A;  1F1W A;  5HKW A;  1SHD A;  4EY0 A;  1D4T A;  1O47 A;  5HKY A;  2DLY A;  5J3X A;  5GJH A;  1RJA A;  2LQN A;  1O4R A;  3CD3 A;  3VRR A;  3K2M A;  1O4C A;  1A07 A;  2EYZ A;  1WQU A;  1A81 A;  3N8M A;  1SPS A;  3MXY A;  1X27 A;  1O4B A;  2MRJ A;  1O4J A;  1KSW A;  3GXX A;  1GRI A;  3T04 A;  3S8L A;  3OVE A;  2CI8 A;  3CBL A;  3BUN B;  1IS0 A;  2HDX A;  2HCK A;  3VS6 A;  1TCE A;  4E93 A;  4H34 A;  2FO0 A;  4E68 A;  1GHU A;  4DGX A;  1TZE E;  3BUX B;  1BG1 A;  2FCI A;  4GPL B;  1RPY A;  3BUO B;  1AYC A;  1PIC A;  4FBN A;  2ROR A;  2XP1 A;  1BKM A;  1R1S A;  3PLF B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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