4JE4A

Crystal structure of monobody nsa1/shp2 n-sh2 domain complex
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
102
structure length
102
Chain Sequence
SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains.
pubmed doi rcsb
molecule tags Signaling protein/protein binding
source organism Homo sapiens
molecule keywords Tyrosine-protein phosphatase non-receptor type 11
total genus 27
structure length 102
sequence length 102
ec nomenclature ec 3.1.3.48: Protein-tyrosine-phosphatase.
pdb deposition date 2013-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00017 SH2 SH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 4je4A00
4K2RA 1A1EA 5EEQA 3OB2B 4OHHA 1R1SA 1KC2A 1P13A 1QCFA 4H1OA 3IN7A 3S9KA 1CSYA 1FU5A 5BO4A 2EL8A 1A07A 5EG3B 2MRJA 4P9VA 3TKZA 2IUHA 3EACA 1JYQA 2Y3AB 3VRQA 4LUDA 1O4GA 1KSWA 1ZFPE 1O44A 3NHNA 1O4JA 1O4EA 1M61A 1RJAA 4M4ZA 2EO3A 3VS0A 2HCKA 2LNXA 1BLKA 2IUIA 1O48A 1FMKA 1R1QA 1BG1A 4X6SA 1LUMA 1AOUF 5EHPA 1AOTF 2EYYA 3QWXX 1O49A 2EKXA 2DLZA 1SPSA 5EELA 2ABLA 3CWGA 1O4OA 3QWYA 1O4FA 1FBZA 3PSJA 2PLDA 4XZ0A 3OVEA 5GJIA 1LKKA 1QG1E 2LNWA 4QSYA 4OHEA 3S8OA 4NWFA 2C0OA 2HMHA 1Y57A 1O4DA 1O4CA 2IZVA 3IMJA 4K45A 2RMXA 4FL2A 1X27A 3OV1A 1A1BA 1LCKA 1CWDL 3VS4A 2RVFA 1LKLA 1O4PA 2RSYA 4OHLA 1BFIA 3C7IA 3PJPA 1O4RA 3PFVA 4E93A 3BUXB 1CSZA 2MQIA 2PLEA 1BKLA 2AOAA 1JU5A 2FCIA 2K7AB 3EAZA 2OQ1A 4F5AA 3VS3A 2XP1A 2LCTA 1O42A 2EU0A 1LUKA 1D4TA 1D4WA 1YVHA 1O4IA 3VS2A 2GSBA 1BHHB 3OB1B 3T04A 3UF4A 5I6VA 1BKMA 1TZEE 2ETZA 2H5KA 4P9ZA 3ZNIA 1FHSA 2BBUA 1M27A 1OPKA 3UYOA 3VRRA 3BUMB 3BUOB 1BLJA 2KNOA 4EY0A 4GPLB 1G83A 4D8KA 2C0TA 2YSXA 4JGHA 1SKJA 4WWQA 3VS6A 1LUIA 2DCRA 1RQQC 1B47A 2CI9A 3BKBA 1AYDA 1O46A 2CBLA 3VRNA 1MW4A 4FBNA 1HCSB 3VRPA 5DC9A 1AYBA 4F59A 1WQUA 2MK2A 5IBMA 2OZOA 2PNBA 1Y1UA 1R1PA 4XZ1A 1SHAA 3PS5A 5CDWA 2JYQA 1A09A 1AD5A 2QMSA 1FYRA 4OHDA 3PQZA 3BUWB 1Z3KA 3N7YA 5KAZA 3MAZA 3N8MA 5DF6A 2SRCA 4H34A 1PICA 3GXWA 4K44A 1O47A 1AB2A 1O4QA 1NZLA 2LQWA 3CXLA 4L1BB 1OPLA 3S8NA 1A08A 1BFJA 1O4LA 3VS5A 1SPRA 2HDVA 1OO4A 3IMDA 2HUWA 2KK6A 1A1CA 1BHFA 1CJ1A 4ROJA 3VGOA 2PTKA 1KA6A 4GWFA 1O4BA 1O4HA 4FL3A 3GQIB 1KA7A 1IJRA 4A4BA 2ECDA 2Y1NA 5GJHA 2DVJA 4K11A 1O45A 2L6KA 3OP0A 1O4AA 3KFJA 4NWGA 3VRYA 2H8HA 3MXYA 5J3XA 2GE9A 1NZVA 1LUNA 2RORA 1K9AA 1O4MA 1OO3A 4DGXA 2HDXA 1NRVA 2SHPA 1BMBA 2AOBA 2IUGA 1AYAA 3M7FA 4U1PA 3PSKA 5DC0B 1SHDA 1A81A 1SHBA 3K2MA 2AUGA 2C0IA 2DM0A 1XA6A 2CRHA 1LCJA 1JWOA 3GXXA 1FBVA 5IBSA 1UUSA 3HHMB 1HCTB 3MXCA 5AULA 3VRZA 4TZIA 1O43A 3CBLA 1I3ZA 1JYUA 2MRKA 3IN8A 3S8LA 4DGPA 2K79B 1GHUA 2EO6A 2VIFA 5HKYA 1X0NA 4A4CA 3US4A 4GL9E 1JYRA 3VS1A 1TCEA 1BF5A 1F1WA 2YU7A 3BUNB 4LUEA 1O4NA 1O4KA 1F2FA 2PNAA 1YVLA 2DLYA 3N84A 2L4KA 1FU6A 3VROA 3HCKA 5DC4A 5HKWA 2B3OA 3VS7A 3TL0A 1GRIA 1A1AA 2EYZA 3CD3A 2CI8A 3PLFB 4EIHA 4JE4A 3HIZB 5AXIA 1IS0A 1BHHA 1MILA 2L3TA 4JEGA 1CWEA 2EYVA 1UURA 4F5BA 2CIAA 2MC1A 4E68A 3WA4A 1D1ZA 1RPYA 1H9OA 5HKZA 4U17A 2FO0A 2CR4A 1X6CA 4OHIA 2EOBA 2Y1MA 1QADA 5EHRA 2C9WA 2LQNA 1O41A 2CS0A 2DX0A 2H46E 1AYCA 5D0JA 1BM2A
chains in the Genus database with same CATH superfamily
4K2RA 1A1EA 5EEQA 3OB2B 4OHHA 1R1SA 1KC2A 1P13A 1QCFA 4H1OA 3IN7A 3S9KA 1CSYA 1FU5A 5BO4A 2EL8A 1A07A 5EG3B 2MRJA 4P9VA 3TKZA 2IUHA 3EACA 1JYQA 2Y3AB 3VRQA 4LUDA 1O4GA 1KSWA 1ZFPE 1O44A 3NHNA 1O4JA 1O4EA 1M61A 1RJAA 4M4ZA 2EO3A 3VS0A 2HCKA 2LNXA 1BLKA 2IUIA 1O48A 1FMKA 1R1QA 1BG1A 4X6SA 1LUMA 1AOUF 5EHPA 1AOTF 2EYYA 3QWXX 1O49A 2EKXA 2DLZA 1SPSA 5EELA 2ABLA 3CWGA 1O4OA 3QWYA 1O4FA 1FBZA 3PSJA 2PLDA 4XZ0A 3OVEA 5GJIA 1LKKA 1QG1E 2LNWA 4QSYA 4OHEA 3S8OA 4NWFA 2C0OA 2HMHA 1Y57A 1O4DA 1O4CA 2IZVA 3IMJA 4K45A 2RMXA 4FL2A 1X27A 3OV1A 1A1BA 1LCKA 1CWDL 3VS4A 2RVFA 1LKLA 1O4PA 2LRAA 2RSYA 4OHLA 1BFIA 3C7IA 3PJPA 1O4RA 3PFVA 4E93A 3BUXB 1CSZA 2MQIA 2PLEA 1BKLA 2AOAA 1JU5A 2FCIA 2K7AB 3EAZA 2OQ1A 4F5AA 3VS3A 2XP1A 2LCTA 1O42A 2EU0A 1LUKA 1D4TA 1D4WA 1YVHA 1O4IA 3VS2A 2GSBA 1BHHB 3OB1B 3T04A 3UF4A 5I6VA 1BKMA 1TZEE 2ETZA 2H5KA 4P9ZA 3ZNIA 1FHSA 2BBUA 1M27A 1OPKA 3UYOA 3VRRA 3BUMB 3BUOB 1BLJA 2KNOA 4EY0A 4GPLB 1G83A 4D8KA 2C0TA 2YSXA 4JGHA 1SKJA 3LYVA 4WWQA 3VS6A 1LUIA 2DCRA 1RQQC 1B47A 2CI9A 3BKBA 1AYDA 1O46A 2CBLA 3VRNA 1MW4A 4FBNA 1HCSB 3VRPA 5DC9A 1AYBA 4F59A 1WQUA 2MK2A 5IBMA 2OZOA 2PNBA 1Y1UA 1R1PA 4XZ1A 1SHAA 3PS5A 5CDWA 2JYQA 1A09A 1AD5A 2QMSA 1FYRA 4OHDA 3PQZA 3BUWB 1Z3KA 3N7YA 5KAZA 3MAZA 3N8MA 5DF6A 2SRCA 4H34A 1PICA 3GXWA 4K44A 1O47A 1AB2A 1O4QA 1NZLA 2LQWA 3CXLA 4L1BB 1OPLA 3S8NA 1A08A 1BFJA 1O4LA 3VS5A 1SPRA 2HDVA 1OO4A 3IMDA 2HUWA 2KK6A 1A1CA 1BHFA 1CJ1A 4ROJA 3VGOA 2PTKA 1KA6A 4GWFA 1O4BA 1O4HA 4FL3A 3GQIB 1KA7A 1IJRA 4A4BA 2ECDA 2Y1NA 5GJHA 2DVJA 4K11A 1O45A 2L6KA 3OP0A 1O4AA 3KFJA 4NWGA 3VRYA 2H8HA 3MXYA 5J3XA 2GE9A 1NZVA 1LUNA 2RORA 1K9AA 1O4MA 1OO3A 4DGXA 2HDXA 1NRVA 2SHPA 1BMBA 2AOBA 2IUGA 1AYAA 3M7FA 4U1PA 3PSKA 5DC0B 1SHDA 1A81A 1SHBA 3K2MA 2AUGA 2C0IA 2DM0A 1XA6A 2CRHA 1LCJA 1JWOA 3GXXA 1FBVA 5IBSA 1UUSA 3HHMB 1HCTB 3MXCA 5AULA 3VRZA 4TZIA 1O43A 3CBLA 1I3ZA 1JYUA 2MRKA 3IN8A 3S8LA 4DGPA 2K79B 1GHUA 2EO6A 2VIFA 5HKYA 1X0NA 4A4CA 3US4A 4GL9E 1JYRA 3VS1A 1TCEA 1BF5A 1F1WA 2YU7A 3BUNB 4LUEA 1O4NA 1O4KA 2KGYA 1F2FA 2PNAA 1YVLA 2DLYA 3N84A 2L4KA 1FU6A 3VROA 3HCKA 5DC4A 5HKWA 2B3OA 3VS7A 3TL0A 1GRIA 1A1AA 2EYZA 3CD3A 2CI8A 3PLFB 4EIHA 4JE4A 3HIZB 5AXIA 1IS0A 1BHHA 1MILA 2L3TA 4JEGA 1CWEA 2EYVA 1UURA 4F5BA 2CIAA 2MC1A 3K2TA 4E68A 3WA4A 1D1ZA 1RPYA 1H9OA 5HKZA 4U17A 2FO0A 2CR4A 1X6CA 4OHIA 2EOBA 2Y1MA 1QADA 5EHRA 2C9WA 2LQNA 1O41A 2CS0A 2DX0A 2H46E 1AYCA 5D0JA 1BM2A
chains in the Genus database with same CATH topology
4K2RA 1A1EA 5EEQA 3OB2B 4OHHA 1R1SA 1KC2A 1P13A 1QCFA 4H1OA 3IN7A 3S9KA 1CSYA 1FU5A 5BO4A 2EL8A 1A07A 5EG3B 2MRJA 4P9VA 3TKZA 2IUHA 3EACA 1JYQA 2Y3AB 3VRQA 4LUDA 1O4GA 1KSWA 1ZFPE 1O44A 3NHNA 1O4JA 1O4EA 1M61A 1RJAA 4M4ZA 2EO3A 3VS0A 2HCKA 2LNXA 1BLKA 2IUIA 1O48A 1FMKA 1R1QA 1BG1A 4X6SA 1LUMA 1AOUF 5EHPA 1AOTF 2EYYA 3QWXX 1O49A 2EKXA 2DLZA 1SPSA 5EELA 2ABLA 3CWGA 1O4OA 3QWYA 1O4FA 1FBZA 3PSJA 2PLDA 4XZ0A 3OVEA 5GJIA 1LKKA 1QG1E 2LNWA 4QSYA 4OHEA 3S8OA 4NWFA 2C0OA 2HMHA 1Y57A 1O4DA 1O4CA 2IZVA 3IMJA 4K45A 2RMXA 4FL2A 1X27A 3OV1A 1A1BA 1LCKA 1CWDL 3VS4A 2RVFA 1LKLA 1O4PA 2RSYA 4OHLA 1BFIA 3C7IA 3PJPA 1O4RA 3PFVA 4E93A 3BUXB 1CSZA 2MQIA 2PLEA 1BKLA 2AOAA 1JU5A 2FCIA 2K7AB 3EAZA 2OQ1A 4F5AA 3VS3A 2XP1A 2LCTA 1O42A 2EU0A 1LUKA 1D4TA 1D4WA 1YVHA 1O4IA 3VS2A 2GSBA 1BHHB 3OB1B 3T04A 3UF4A 5I6VA 1BKMA 1TZEE 2ETZA 2H5KA 4P9ZA 3ZNIA 1FHSA 2BBUA 1M27A 1OPKA 3UYOA 3VRRA 3BUMB 3BUOB 1BLJA 2KNOA 4EY0A 4GPLB 1G83A 4D8KA 2C0TA 2YSXA 4JGHA 1SKJA 4WWQA 3VS6A 1LUIA 2DCRA 1RQQC 1B47A 2CI9A 3BKBA 1AYDA 1O46A 2CBLA 3VRNA 1MW4A 4FBNA 1HCSB 3VRPA 5DC9A 1AYBA 4F59A 1WQUA 2MK2A 5IBMA 2OZOA 2PNBA 1Y1UA 1R1PA 4XZ1A 1SHAA 3PS5A 5CDWA 2JYQA 1A09A 1AD5A 2QMSA 1FYRA 4OHDA 3PQZA 3BUWB 1Z3KA 3N7YA 5KAZA 3MAZA 3N8MA 5DF6A 2SRCA 4H34A 1PICA 3GXWA 4K44A 1O47A 1AB2A 1O4QA 1NZLA 2LQWA 3CXLA 4L1BB 1OPLA 3S8NA 1A08A 1BFJA 1O4LA 3VS5A 1SPRA 2HDVA 1OO4A 3IMDA 2HUWA 2KK6A 1A1CA 1BHFA 1CJ1A 4ROJA 3VGOA 2PTKA 1KA6A 4GWFA 1O4BA 1O4HA 4FL3A 3GQIB 1KA7A 1IJRA 4A4BA 2ECDA 2Y1NA 5GJHA 2DVJA 4K11A 1O45A 2L6KA 3OP0A 1O4AA 3KFJA 4NWGA 3VRYA 2H8HA 3MXYA 5J3XA 2GE9A 1NZVA 1LUNA 2RORA 1K9AA 1O4MA 1OO3A 4DGXA 2HDXA 1NRVA 2SHPA 1BMBA 2AOBA 2IUGA 1AYAA 3M7FA 4U1PA 3PSKA 5DC0B 1SHDA 1A81A 1SHBA 3K2MA 2AUGA 2C0IA 2DM0A 1XA6A 2CRHA 1LCJA 1JWOA 3GXXA 1FBVA 5IBSA 1UUSA 3HHMB 1HCTB 3MXCA 5AULA 3VRZA 4TZIA 1O43A 3CBLA 1I3ZA 1JYUA 2MRKA 3IN8A 3S8LA 4DGPA 2K79B 1GHUA 2EO6A 2VIFA 5HKYA 1X0NA 4A4CA 3US4A 4GL9E 1JYRA 3VS1A 1TCEA 1BF5A 1F1WA 2YU7A 3BUNB 4LUEA 1O4NA 1O4KA 1F2FA 2PNAA 1YVLA 2DLYA 3N84A 2L4KA 1FU6A 3VROA 3HCKA 5DC4A 5HKWA 2B3OA 3VS7A 3TL0A 1GRIA 1A1AA 2EYZA 3CD3A 2CI8A 3PLFB 4EIHA 4JE4A 3HIZB 5AXIA 1IS0A 1BHHA 1MILA 2L3TA 4JEGA 1CWEA 2EYVA 1UURA 4F5BA 2CIAA 2MC1A 4E68A 3WA4A 1D1ZA 1RPYA 1H9OA 5HKZA 4U17A 2FO0A 2CR4A 1X6CA 4OHIA 2EOBA 2Y1MA 1QADA 5EHRA 2C9WA 2LQNA 1O41A 2CS0A 2DX0A 2H46E 1AYCA 5D0JA 1BM2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4K2R A;  1A1E A;  5EEQ A;  3OB2 B;  4OHH A;  1R1S A;  1KC2 A;  1P13 A;  1QCF A;  4H1O A;  3IN7 A;  3S9K A;  1CSY A;  1FU5 A;  5BO4 A;  2EL8 A;  1A07 A;  5EG3 B;  2MRJ A;  4P9V A;  3TKZ A;  2IUH A;  3EAC A;  1JYQ A;  2Y3A B;  3VRQ A;  4LUD A;  1O4G A;  1KSW A;  1ZFP E;  1O44 A;  3NHN A;  1O4J A;  1O4E A;  1M61 A;  1RJA A;  4M4Z A;  2EO3 A;  3VS0 A;  2HCK A;  2LNX A;  1BLK A;  2IUI A;  1O48 A;  1FMK A;  1R1Q A;  1BG1 A;  4X6S A;  1LUM A;  1AOU F;  5EHP A;  1AOT F;  2EYY A;  3QWX X;  1O49 A;  2EKX A;  2DLZ A;  1SPS A;  5EEL A;  2ABL A;  3CWG A;  1O4O A;  3QWY A;  1O4F A;  1FBZ A;  3PSJ A;  2PLD A;  4XZ0 A;  3OVE A;  5GJI A;  1LKK A;  1QG1 E;  2LNW A;  4QSY A;  4OHE A;  3S8O A;  4NWF A;  2C0O A;  2HMH A;  1Y57 A;  1O4D A;  1O4C A;  2IZV A;  3IMJ A;  4K45 A;  2RMX A;  4FL2 A;  1X27 A;  3OV1 A;  1A1B A;  1LCK A;  1CWD L;  3VS4 A;  2RVF A;  1LKL A;  1O4P A;  2RSY A;  4OHL A;  1BFI A;  3C7I A;  3PJP A;  1O4R A;  3PFV A;  4E93 A;  3BUX B;  1CSZ A;  2MQI A;  2PLE A;  1BKL A;  2AOA A;  1JU5 A;  2FCI A;  2K7A B;  3EAZ A;  2OQ1 A;  4F5A A;  3VS3 A;  2XP1 A;  2LCT A;  1O42 A;  2EU0 A;  1LUK A;  1D4T A;  1D4W A;  1YVH A;  1O4I A;  3VS2 A;  2GSB A;  1BHH B;  3OB1 B;  3T04 A;  3UF4 A;  5I6V A;  1BKM A;  1TZE E;  2ETZ A;  2H5K A;  4P9Z A;  3ZNI A;  1FHS A;  2BBU A;  1M27 A;  1OPK A;  3UYO A;  3VRR A;  3BUM B;  3BUO B;  1BLJ A;  2KNO A;  4EY0 A;  4GPL B;  1G83 A;  4D8K A;  2C0T A;  2YSX A;  4JGH A;  1SKJ A;  4WWQ A;  3VS6 A;  1LUI A;  2DCR A;  1RQQ C;  1B47 A;  2CI9 A;  3BKB A;  1AYD A;  1O46 A;  2CBL A;  3VRN A;  1MW4 A;  4FBN A;  1HCS B;  3VRP A;  5DC9 A;  1AYB A;  4F59 A;  1WQU A;  2MK2 A;  5IBM A;  2OZO A;  2PNB A;  1Y1U A;  1R1P A;  4XZ1 A;  1SHA A;  3PS5 A;  5CDW A;  2JYQ A;  1A09 A;  1AD5 A;  2QMS A;  1FYR A;  4OHD A;  3PQZ A;  3BUW B;  1Z3K A;  3N7Y A;  5KAZ A;  3MAZ A;  3N8M A;  5DF6 A;  2SRC A;  4H34 A;  1PIC A;  3GXW A;  4K44 A;  1O47 A;  1AB2 A;  1O4Q A;  1NZL A;  2LQW A;  3CXL A;  4L1B B;  1OPL A;  3S8N A;  1A08 A;  1BFJ A;  1O4L A;  3VS5 A;  1SPR A;  2HDV A;  1OO4 A;  3IMD A;  2HUW A;  2KK6 A;  1A1C A;  1BHF A;  1CJ1 A;  4ROJ A;  3VGO A;  2PTK A;  1KA6 A;  4GWF A;  1O4B A;  1O4H A;  4FL3 A;  3GQI B;  1KA7 A;  1IJR A;  4A4B A;  2ECD A;  2Y1N A;  5GJH A;  2DVJ A;  4K11 A;  1O45 A;  2L6K A;  3OP0 A;  1O4A A;  3KFJ A;  4NWG A;  3VRY A;  2H8H A;  3MXY A;  5J3X A;  2GE9 A;  1NZV A;  1LUN A;  2ROR A;  1K9A A;  1O4M A;  1OO3 A;  4DGX A;  2HDX A;  1NRV A;  2SHP A;  1BMB A;  2AOB A;  2IUG A;  1AYA A;  3M7F A;  4U1P A;  3PSK A;  5DC0 B;  1SHD A;  1A81 A;  1SHB A;  3K2M A;  2AUG A;  2C0I A;  2DM0 A;  1XA6 A;  2CRH A;  1LCJ A;  1JWO A;  3GXX A;  1FBV A;  5IBS A;  1UUS A;  3HHM B;  1HCT B;  3MXC A;  5AUL A;  3VRZ A;  4TZI A;  1O43 A;  3CBL A;  1I3Z A;  1JYU A;  2MRK A;  3IN8 A;  3S8L A;  4DGP A;  2K79 B;  1GHU A;  2EO6 A;  2VIF A;  5HKY A;  1X0N A;  4A4C A;  3US4 A;  4GL9 E;  1JYR A;  3VS1 A;  1TCE A;  1BF5 A;  1F1W A;  2YU7 A;  3BUN B;  4LUE A;  1O4N A;  1O4K A;  1F2F A;  2PNA A;  1YVL A;  2DLY A;  3N84 A;  2L4K A;  1FU6 A;  3VRO A;  3HCK A;  5DC4 A;  5HKW A;  2B3O A;  3VS7 A;  3TL0 A;  1GRI A;  1A1A A;  2EYZ A;  3CD3 A;  2CI8 A;  3PLF B;  4EIH A;  4JE4 A;  3HIZ B;  5AXI A;  1IS0 A;  1BHH A;  1MIL A;  2L3T A;  4JEG A;  1CWE A;  2EYV A;  1UUR A;  4F5B A;  2CIA A;  2MC1 A;  4E68 A;  3WA4 A;  1D1Z A;  1RPY A;  1H9O A;  5HKZ A;  4U17 A;  2FO0 A;  2CR4 A;  1X6C A;  4OHI A;  2EOB A;  2Y1M A;  1QAD A;  5EHR A;  2C9W A;  2LQN A;  1O41 A;  2CS0 A;  2DX0 A;  2H46 E;  1AYC A;  5D0J A;  1BM2 A; 
#chains in the Genus database with same CATH topology
 4K2R A;  1A1E A;  5EEQ A;  3OB2 B;  4OHH A;  1R1S A;  1KC2 A;  1P13 A;  1QCF A;  4H1O A;  3IN7 A;  3S9K A;  1CSY A;  1FU5 A;  5BO4 A;  2EL8 A;  1A07 A;  5EG3 B;  2MRJ A;  4P9V A;  3TKZ A;  2IUH A;  3EAC A;  1JYQ A;  2Y3A B;  3VRQ A;  4LUD A;  1O4G A;  1KSW A;  1ZFP E;  1O44 A;  3NHN A;  1O4J A;  1O4E A;  1M61 A;  1RJA A;  4M4Z A;  2EO3 A;  3VS0 A;  2HCK A;  2LNX A;  1BLK A;  2IUI A;  1O48 A;  1FMK A;  1R1Q A;  1BG1 A;  4X6S A;  1LUM A;  1AOU F;  5EHP A;  1AOT F;  2EYY A;  3QWX X;  1O49 A;  2EKX A;  2DLZ A;  1SPS A;  5EEL A;  2ABL A;  3CWG A;  1O4O A;  3QWY A;  1O4F A;  1FBZ A;  3PSJ A;  2PLD A;  4XZ0 A;  3OVE A;  5GJI A;  1LKK A;  1QG1 E;  2LNW A;  4QSY A;  4OHE A;  3S8O A;  4NWF A;  2C0O A;  2HMH A;  1Y57 A;  1O4D A;  1O4C A;  2IZV A;  3IMJ A;  4K45 A;  2RMX A;  4FL2 A;  1X27 A;  3OV1 A;  1A1B A;  1LCK A;  1CWD L;  3VS4 A;  2RVF A;  1LKL A;  1O4P A;  2LRA A;  2RSY A;  4OHL A;  1BFI A;  3C7I A;  3PJP A;  1O4R A;  3PFV A;  4E93 A;  3BUX B;  1CSZ A;  2MQI A;  2PLE A;  1BKL A;  2AOA A;  1JU5 A;  2FCI A;  2K7A B;  3EAZ A;  2OQ1 A;  4F5A A;  3VS3 A;  2XP1 A;  2LCT A;  1O42 A;  2EU0 A;  1LUK A;  1D4T A;  1D4W A;  1YVH A;  1O4I A;  3VS2 A;  2GSB A;  1BHH B;  3OB1 B;  3T04 A;  3UF4 A;  5I6V A;  1BKM A;  1TZE E;  2ETZ A;  2H5K A;  4P9Z A;  3ZNI A;  1FHS A;  2BBU A;  1M27 A;  1OPK A;  3UYO A;  3VRR A;  3BUM B;  3BUO B;  1BLJ A;  2KNO A;  4EY0 A;  4GPL B;  1G83 A;  4D8K A;  2C0T A;  2YSX A;  4JGH A;  1SKJ A;  3LYV A;  4WWQ A;  3VS6 A;  1LUI A;  2DCR A;  1RQQ C;  1B47 A;  2CI9 A;  3BKB A;  1AYD A;  1O46 A;  2CBL A;  3VRN A;  1MW4 A;  4FBN A;  1HCS B;  3VRP A;  5DC9 A;  1AYB A;  4F59 A;  1WQU A;  2MK2 A;  5IBM A;  2OZO A;  2PNB A;  1Y1U A;  1R1P A;  4XZ1 A;  1SHA A;  3PS5 A;  5CDW A;  2JYQ A;  1A09 A;  1AD5 A;  2QMS A;  1FYR A;  4OHD A;  3PQZ A;  3BUW B;  1Z3K A;  3N7Y A;  5KAZ A;  3MAZ A;  3N8M A;  5DF6 A;  2SRC A;  4H34 A;  1PIC A;  3GXW A;  4K44 A;  1O47 A;  1AB2 A;  1O4Q A;  1NZL A;  2LQW A;  3CXL A;  4L1B B;  1OPL A;  3S8N A;  1A08 A;  1BFJ A;  1O4L A;  3VS5 A;  1SPR A;  2HDV A;  1OO4 A;  3IMD A;  2HUW A;  2KK6 A;  1A1C A;  1BHF A;  1CJ1 A;  4ROJ A;  3VGO A;  2PTK A;  1KA6 A;  4GWF A;  1O4B A;  1O4H A;  4FL3 A;  3GQI B;  1KA7 A;  1IJR A;  4A4B A;  2ECD A;  2Y1N A;  5GJH A;  2DVJ A;  4K11 A;  1O45 A;  2L6K A;  3OP0 A;  1O4A A;  3KFJ A;  4NWG A;  3VRY A;  2H8H A;  3MXY A;  5J3X A;  2GE9 A;  1NZV A;  1LUN A;  2ROR A;  1K9A A;  1O4M A;  1OO3 A;  4DGX A;  2HDX A;  1NRV A;  2SHP A;  1BMB A;  2AOB A;  2IUG A;  1AYA A;  3M7F A;  4U1P A;  3PSK A;  5DC0 B;  1SHD A;  1A81 A;  1SHB A;  3K2M A;  2AUG A;  2C0I A;  2DM0 A;  1XA6 A;  2CRH A;  1LCJ A;  1JWO A;  3GXX A;  1FBV A;  5IBS A;  1UUS A;  3HHM B;  1HCT B;  3MXC A;  5AUL A;  3VRZ A;  4TZI A;  1O43 A;  3CBL A;  1I3Z A;  1JYU A;  2MRK A;  3IN8 A;  3S8L A;  4DGP A;  2K79 B;  1GHU A;  2EO6 A;  2VIF A;  5HKY A;  1X0N A;  4A4C A;  3US4 A;  4GL9 E;  1JYR A;  3VS1 A;  1TCE A;  1BF5 A;  1F1W A;  2YU7 A;  3BUN B;  4LUE A;  1O4N A;  1O4K A;  2KGY A;  1F2F A;  2PNA A;  1YVL A;  2DLY A;  3N84 A;  2L4K A;  1FU6 A;  3VRO A;  3HCK A;  5DC4 A;  5HKW A;  2B3O A;  3VS7 A;  3TL0 A;  1GRI A;  1A1A A;  2EYZ A;  3CD3 A;  2CI8 A;  3PLF B;  4EIH A;  4JE4 A;  3HIZ B;  5AXI A;  1IS0 A;  1BHH A;  1MIL A;  2L3T A;  4JEG A;  1CWE A;  2EYV A;  1UUR A;  4F5B A;  2CIA A;  2MC1 A;  3K2T A;  4E68 A;  3WA4 A;  1D1Z A;  1RPY A;  1H9O A;  5HKZ A;  4U17 A;  2FO0 A;  2CR4 A;  1X6C A;  4OHI A;  2EOB A;  2Y1M A;  1QAD A;  5EHR A;  2C9W A;  2LQN A;  1O41 A;  2CS0 A;  2DX0 A;  2H46 E;  1AYC A;  5D0J A;  1BM2 A; 
#chains in the Genus database with same CATH homology
 4K2R A;  1A1E A;  5EEQ A;  3OB2 B;  4OHH A;  1R1S A;  1KC2 A;  1P13 A;  1QCF A;  4H1O A;  3IN7 A;  3S9K A;  1CSY A;  1FU5 A;  5BO4 A;  2EL8 A;  1A07 A;  5EG3 B;  2MRJ A;  4P9V A;  3TKZ A;  2IUH A;  3EAC A;  1JYQ A;  2Y3A B;  3VRQ A;  4LUD A;  1O4G A;  1KSW A;  1ZFP E;  1O44 A;  3NHN A;  1O4J A;  1O4E A;  1M61 A;  1RJA A;  4M4Z A;  2EO3 A;  3VS0 A;  2HCK A;  2LNX A;  1BLK A;  2IUI A;  1O48 A;  1FMK A;  1R1Q A;  1BG1 A;  4X6S A;  1LUM A;  1AOU F;  5EHP A;  1AOT F;  2EYY A;  3QWX X;  1O49 A;  2EKX A;  2DLZ A;  1SPS A;  5EEL A;  2ABL A;  3CWG A;  1O4O A;  3QWY A;  1O4F A;  1FBZ A;  3PSJ A;  2PLD A;  4XZ0 A;  3OVE A;  5GJI A;  1LKK A;  1QG1 E;  2LNW A;  4QSY A;  4OHE A;  3S8O A;  4NWF A;  2C0O A;  2HMH A;  1Y57 A;  1O4D A;  1O4C A;  2IZV A;  3IMJ A;  4K45 A;  2RMX A;  4FL2 A;  1X27 A;  3OV1 A;  1A1B A;  1LCK A;  1CWD L;  3VS4 A;  2RVF A;  1LKL A;  1O4P A;  2RSY A;  4OHL A;  1BFI A;  3C7I A;  3PJP A;  1O4R A;  3PFV A;  4E93 A;  3BUX B;  1CSZ A;  2MQI A;  2PLE A;  1BKL A;  2AOA A;  1JU5 A;  2FCI A;  2K7A B;  3EAZ A;  2OQ1 A;  4F5A A;  3VS3 A;  2XP1 A;  2LCT A;  1O42 A;  2EU0 A;  1LUK A;  1D4T A;  1D4W A;  1YVH A;  1O4I A;  3VS2 A;  2GSB A;  1BHH B;  3OB1 B;  3T04 A;  3UF4 A;  5I6V A;  1BKM A;  1TZE E;  2ETZ A;  2H5K A;  4P9Z A;  3ZNI A;  1FHS A;  2BBU A;  1M27 A;  1OPK A;  3UYO A;  3VRR A;  3BUM B;  3BUO B;  1BLJ A;  2KNO A;  4EY0 A;  4GPL B;  1G83 A;  4D8K A;  2C0T A;  2YSX A;  4JGH A;  1SKJ A;  4WWQ A;  3VS6 A;  1LUI A;  2DCR A;  1RQQ C;  1B47 A;  2CI9 A;  3BKB A;  1AYD A;  1O46 A;  2CBL A;  3VRN A;  1MW4 A;  4FBN A;  1HCS B;  3VRP A;  5DC9 A;  1AYB A;  4F59 A;  1WQU A;  2MK2 A;  5IBM A;  2OZO A;  2PNB A;  1Y1U A;  1R1P A;  4XZ1 A;  1SHA A;  3PS5 A;  5CDW A;  2JYQ A;  1A09 A;  1AD5 A;  2QMS A;  1FYR A;  4OHD A;  3PQZ A;  3BUW B;  1Z3K A;  3N7Y A;  5KAZ A;  3MAZ A;  3N8M A;  5DF6 A;  2SRC A;  4H34 A;  1PIC A;  3GXW A;  4K44 A;  1O47 A;  1AB2 A;  1O4Q A;  1NZL A;  2LQW A;  3CXL A;  4L1B B;  1OPL A;  3S8N A;  1A08 A;  1BFJ A;  1O4L A;  3VS5 A;  1SPR A;  2HDV A;  1OO4 A;  3IMD A;  2HUW A;  2KK6 A;  1A1C A;  1BHF A;  1CJ1 A;  4ROJ A;  3VGO A;  2PTK A;  1KA6 A;  4GWF A;  1O4B A;  1O4H A;  4FL3 A;  3GQI B;  1KA7 A;  1IJR A;  4A4B A;  2ECD A;  2Y1N A;  5GJH A;  2DVJ A;  4K11 A;  1O45 A;  2L6K A;  3OP0 A;  1O4A A;  3KFJ A;  4NWG A;  3VRY A;  2H8H A;  3MXY A;  5J3X A;  2GE9 A;  1NZV A;  1LUN A;  2ROR A;  1K9A A;  1O4M A;  1OO3 A;  4DGX A;  2HDX A;  1NRV A;  2SHP A;  1BMB A;  2AOB A;  2IUG A;  1AYA A;  3M7F A;  4U1P A;  3PSK A;  5DC0 B;  1SHD A;  1A81 A;  1SHB A;  3K2M A;  2AUG A;  2C0I A;  2DM0 A;  1XA6 A;  2CRH A;  1LCJ A;  1JWO A;  3GXX A;  1FBV A;  5IBS A;  1UUS A;  3HHM B;  1HCT B;  3MXC A;  5AUL A;  3VRZ A;  4TZI A;  1O43 A;  3CBL A;  1I3Z A;  1JYU A;  2MRK A;  3IN8 A;  3S8L A;  4DGP A;  2K79 B;  1GHU A;  2EO6 A;  2VIF A;  5HKY A;  1X0N A;  4A4C A;  3US4 A;  4GL9 E;  1JYR A;  3VS1 A;  1TCE A;  1BF5 A;  1F1W A;  2YU7 A;  3BUN B;  4LUE A;  1O4N A;  1O4K A;  1F2F A;  2PNA A;  1YVL A;  2DLY A;  3N84 A;  2L4K A;  1FU6 A;  3VRO A;  3HCK A;  5DC4 A;  5HKW A;  2B3O A;  3VS7 A;  3TL0 A;  1GRI A;  1A1A A;  2EYZ A;  3CD3 A;  2CI8 A;  3PLF B;  4EIH A;  4JE4 A;  3HIZ B;  5AXI A;  1IS0 A;  1BHH A;  1MIL A;  2L3T A;  4JEG A;  1CWE A;  2EYV A;  1UUR A;  4F5B A;  2CIA A;  2MC1 A;  4E68 A;  3WA4 A;  1D1Z A;  1RPY A;  1H9O A;  5HKZ A;  4U17 A;  2FO0 A;  2CR4 A;  1X6C A;  4OHI A;  2EOB A;  2Y1M A;  1QAD A;  5EHR A;  2C9W A;  2LQN A;  1O41 A;  2CS0 A;  2DX0 A;  2H46 E;  1AYC A;  5D0J A;  1BM2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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