4FBNA

Insights into structural integration of the plcgamma regulatory region and mechanism of autoinhibition and activation based on key roles of sh2 domains
Total Genus 58
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
243
structure length
232
Chain Sequence
NEKWFHGKLGAGDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGYVEANPM
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga
total genus 58
structure length 232
sequence length 243
ec nomenclature ec 3.1.4.11: Phosphoinositide phospholipase C.
pdb deposition date 2012-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00017 SH2 SH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 4fbnA02
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 4fbnA01
4D8KA 1K9AA 3KFJA 4OHEA 1BFIA 3VRPA 2QMSA 4U17A 3TL0A 1AB2A 3OV1A 1X27A 5IBSA 1BKLA 1A08A 4OHLA 2MQIA 2H46E 2IUIA 2CR4A 3M7FA 3IN8A 2CI9A 1CSYA 1F2FA 1OO4A 4TZIA 1BHHB 3OB2B 4F5BA 1KA6A 2LCTA 4A4CA 1A1BA 2PLDA 1JU5A 1RQQC 4A4BA 5AXIA 2LQWA 1I3ZA 1JWOA 1CWDL 3BUMB 2HCKA 3S8OA 1O4GA 2EYYA 1BMBA 4JGHA 1MILA 1NZLA 3K2MA 1ZFPE 1O41A 2FCIA 4NWFA 1LUIA 2EL8A 3US4A 4DGPA 2LQNA 1BHFA 3N8MA 4P9ZA 5GJIA 2IUHA 4K11A 2LNXA 5HKWA 4FBNA 3HCKA 1QG1E 1KSWA 2C9WA 5HKYA 3IMDA 4GPLB 2AUGA 1O4CA 1A1AA 2YU7A 1A09A 1O4AA 1PICA 4XZ1A 1B47A 3QWXX 2HUWA 3PS5A 1A07A 3VGOA 1O4HA 1O4LA 1O4KA 2MK2A 2SHPA 2DLYA 2ABLA 1JYUA 2H8HA 1SHDA 2L6KA 4H1OA 3OP0A 3C7IA 3VRZA 2DCRA 1LUNA 2OZOA 4NWGA 1O4DA 2ETZA 1D1ZA 1CWEA 1FBZA 5KAZA 1R1QA 4OHHA 1BLKA 2SRCA 1TZEE 3N7YA 1AYDA 5AULA 5IBMA 1LUKA 1NRVA 2L4KA 2K79B 1FBVA 1O4FA 1XA6A 1SHBA 3VS2A 2DVJA 2CRHA 2PNBA 3CXLA 4K2RA 2ECDA 3VS5A 2DLZA 4F59A 1A81A 5DC9A 1UUSA 1BG1A 1O45A 1BM2A 2EO6A 3EACA 1O46A 1GHUA 3PQZA 1D4WA 2RORA 2KK6A 5I6VA 1JYQA 3PJPA 1RPYA 1OPLA 3CD3A 1O47A 2BBUA 4GL9E 3HHMB 1QCFA 2CS0A 1FHSA 1O4BA 1BFJA 2GSBA 1AYCA 3ZNIA 2JYQA 4LUEA 5BO4A 4WWQA 2HDVA 2K7AB 1O4QA 1LKLA 3UYOA 3MXYA 1O42A 1Z3KA 2YSXA 1LCKA 5HKZA 1IJRA 1O4OA 1YVHA 2AOBA 4E68A 3VS7A 4K44A 1R1PA 3GQIB 3S8LA 3IN7A 1O4EA 5D0JA 1SPSA 1NZVA 3GXWA 1A1CA 2L3TA 1O49A 3S8NA 1Y1UA 3BUOB 1FU5A 2PTKA 4EY0A 2LNWA 1SPRA 1O48A 2RSYA 3NHNA 2AOAA 1BLJA 2CIAA 2C0TA 3VROA 1GRIA 5GJHA 3VS0A 4EIHA 4XZ0A 3BUXB 3TKZA 2PNAA 2HDXA 1H9OA 2C0OA 2EKXA 3CBLA 1BHHA 4LUDA 2C0IA 1P13A 2EOBA 1BF5A 3VS4A 1FU6A 3PSKA 3VS3A 2CBLA 3VRNA 3N84A 2MRKA 2EYZA 1YVLA 3HIZB 1CSZA 1FYRA 1G83A 2HMHA 3VRQA 1AYAA 1O4NA 1X6CA 3VRRA 2IUGA 1KA7A 5CDWA 1AD5A 1HCTB 2IZVA 4F5AA 2B3OA 1OPKA 2DX0A 2KNOA 1O4IA 1A1EA 1AOTF 2Y1NA 2FO0A 1LKKA 2DM0A 3VS1A 4FL2A 4FL3A 5EELA 4GWFA 1TCEA 5EHRA 3MXCA 1QADA 5EHPA 5EG3B 2EYVA 3EAZA 4ROJA 4JEGA 3IMJA 2PLEA 2RVFA 2VIFA 3BUWB 1FMKA 2XP1A 1O4RA 3PSJA 3T04A 2RMXA 4QSYA 3VS6A 1X0NA 1AOUF 4H34A 3BKBA 3GXXA 2GE9A 2OQ1A 3CWGA 2H5KA 3OB1B 2MRJA 1R1SA 1HCSB 2CI8A 1O4JA 4DGXA 1O4MA 4L1BB 1M61A 1O44A 3MAZA 2EU0A 4X6SA 1AYBA 2MC1A 4M4ZA 4OHIA 1CJ1A 1SHAA 2Y1MA 3WA4A 4K45A 4U1PA 3PLFB 1SKJA 5EEQA 3PFVA 4P9VA 5J3XA 1M27A 3OVEA 1RJAA 2EO3A 1O4PA 3QWYA 2Y3AB 1O43A 1MW4A 5DC4A 1UURA 1JYRA 1LUMA 3BUNB 1Y57A 1OO3A 1BKMA 1KC2A 5DC0B 1F1WA 3UF4A 1D4TA 4E93A 3S9KA 1IS0A 1WQUA 5DF6A 4JE4A 1LCJA 3VRYA 4OHDA
chains in the Genus database with same CATH superfamily
4D8KA 1K9AA 3KFJA 4OHEA 1BFIA 3VRPA 2QMSA 4U17A 3TL0A 1AB2A 3OV1A 1X27A 5IBSA 1BKLA 1A08A 4OHLA 2MQIA 2H46E 2IUIA 2CR4A 3M7FA 3IN8A 2CI9A 1CSYA 1F2FA 1OO4A 4TZIA 1BHHB 3OB2B 4F5BA 1KA6A 2LCTA 4A4CA 1A1BA 2PLDA 1JU5A 1RQQC 2KGYA 4A4BA 5AXIA 2LQWA 1I3ZA 1JWOA 1CWDL 3BUMB 2HCKA 3S8OA 1O4GA 2EYYA 1BMBA 4JGHA 1MILA 1NZLA 3K2MA 1ZFPE 1O41A 2FCIA 4NWFA 1LUIA 2EL8A 3K2TA 3US4A 4DGPA 2LQNA 1BHFA 3N8MA 4P9ZA 5GJIA 2IUHA 4K11A 2LNXA 5HKWA 4FBNA 3HCKA 1QG1E 1KSWA 2C9WA 5HKYA 3IMDA 4GPLB 2AUGA 1O4CA 1A1AA 2YU7A 1A09A 1O4AA 1PICA 4XZ1A 1B47A 3QWXX 2HUWA 3PS5A 1A07A 3VGOA 1O4HA 1O4LA 1O4KA 2MK2A 2SHPA 2DLYA 2ABLA 1JYUA 2H8HA 1SHDA 2L6KA 4H1OA 3OP0A 3C7IA 3VRZA 2DCRA 1LUNA 2OZOA 4NWGA 1O4DA 2ETZA 1D1ZA 1CWEA 1FBZA 5KAZA 1R1QA 4OHHA 1BLKA 2SRCA 1TZEE 3N7YA 1AYDA 5AULA 5IBMA 1LUKA 1NRVA 2L4KA 2K79B 1FBVA 1O4FA 1XA6A 1SHBA 3VS2A 2DVJA 2CRHA 2PNBA 3CXLA 4K2RA 2ECDA 3VS5A 2DLZA 4F59A 1A81A 5DC9A 1UUSA 1BG1A 1O45A 1BM2A 2EO6A 3EACA 1O46A 1GHUA 3PQZA 1D4WA 2RORA 2KK6A 5I6VA 1JYQA 3PJPA 2LRAA 1RPYA 1OPLA 3CD3A 1O47A 2BBUA 4GL9E 3HHMB 1QCFA 2CS0A 1FHSA 1O4BA 1BFJA 2GSBA 1AYCA 3ZNIA 2JYQA 4LUEA 5BO4A 4WWQA 2HDVA 2K7AB 1O4QA 1LKLA 3UYOA 3MXYA 1O42A 1Z3KA 2YSXA 1LCKA 5HKZA 1IJRA 1O4OA 1YVHA 2AOBA 4E68A 3VS7A 4K44A 1R1PA 3GQIB 3S8LA 3IN7A 1O4EA 5D0JA 1SPSA 1NZVA 3GXWA 1A1CA 2L3TA 1O49A 3S8NA 1Y1UA 3BUOB 1FU5A 2PTKA 4EY0A 2LNWA 1SPRA 1O48A 2RSYA 3NHNA 2AOAA 1BLJA 2CIAA 2C0TA 3VROA 1GRIA 5GJHA 3VS0A 4EIHA 4XZ0A 3BUXB 3TKZA 2PNAA 2HDXA 1H9OA 2C0OA 2EKXA 3CBLA 1BHHA 4LUDA 2C0IA 1P13A 2EOBA 1BF5A 3VS4A 1FU6A 3PSKA 3VS3A 2CBLA 3VRNA 3N84A 2MRKA 2EYZA 1YVLA 3HIZB 1CSZA 1FYRA 1G83A 2HMHA 3VRQA 1AYAA 1O4NA 1X6CA 3LYVA 3VRRA 2IUGA 1KA7A 5CDWA 1AD5A 1HCTB 2IZVA 4F5AA 2B3OA 1OPKA 2DX0A 2KNOA 1O4IA 1A1EA 1AOTF 2Y1NA 2FO0A 1LKKA 2DM0A 3VS1A 4FL2A 4FL3A 5EELA 4GWFA 1TCEA 5EHRA 3MXCA 1QADA 5EHPA 5EG3B 2EYVA 3EAZA 4ROJA 4JEGA 3IMJA 2PLEA 2RVFA 2VIFA 3BUWB 1FMKA 2XP1A 1O4RA 3PSJA 3T04A 2RMXA 4QSYA 3VS6A 1X0NA 1AOUF 4H34A 3BKBA 3GXXA 2GE9A 2OQ1A 3CWGA 2H5KA 3OB1B 2MRJA 1R1SA 1HCSB 2CI8A 1O4JA 4DGXA 1O4MA 4L1BB 1M61A 1O44A 3MAZA 2EU0A 4X6SA 1AYBA 2MC1A 4M4ZA 4OHIA 1CJ1A 1SHAA 2Y1MA 3WA4A 4K45A 4U1PA 3PLFB 1SKJA 5EEQA 3PFVA 4P9VA 5J3XA 1M27A 3OVEA 1RJAA 2EO3A 1O4PA 3QWYA 2Y3AB 1O43A 1MW4A 5DC4A 1UURA 1JYRA 1LUMA 3BUNB 1Y57A 1OO3A 1BKMA 1KC2A 5DC0B 1F1WA 3UF4A 1D4TA 4E93A 3S9KA 1IS0A 1WQUA 5DF6A 4JE4A 1LCJA 3VRYA 4OHDA
chains in the Genus database with same CATH topology
4D8KA 1K9AA 3KFJA 4OHEA 1BFIA 3VRPA 2QMSA 4U17A 3TL0A 1AB2A 3OV1A 1X27A 5IBSA 1BKLA 1A08A 4OHLA 2MQIA 2H46E 2IUIA 2CR4A 3M7FA 3IN8A 2CI9A 1CSYA 1F2FA 1OO4A 4TZIA 1BHHB 3OB2B 4F5BA 1KA6A 2LCTA 4A4CA 1A1BA 2PLDA 1JU5A 1RQQC 4A4BA 5AXIA 2LQWA 1I3ZA 1JWOA 1CWDL 3BUMB 2HCKA 3S8OA 1O4GA 2EYYA 1BMBA 4JGHA 1MILA 1NZLA 3K2MA 1ZFPE 1O41A 2FCIA 4NWFA 1LUIA 2EL8A 3US4A 4DGPA 2LQNA 1BHFA 3N8MA 4P9ZA 5GJIA 2IUHA 4K11A 2LNXA 5HKWA 4FBNA 3HCKA 1QG1E 1KSWA 2C9WA 5HKYA 3IMDA 4GPLB 2AUGA 1O4CA 1A1AA 2YU7A 1A09A 1O4AA 1PICA 4XZ1A 1B47A 3QWXX 2HUWA 3PS5A 1A07A 3VGOA 1O4HA 1O4LA 1O4KA 2MK2A 2SHPA 2DLYA 2ABLA 1JYUA 2H8HA 1SHDA 2L6KA 4H1OA 3OP0A 3C7IA 3VRZA 2DCRA 1LUNA 2OZOA 4NWGA 1O4DA 2ETZA 1D1ZA 1CWEA 1FBZA 5KAZA 1R1QA 4OHHA 1BLKA 2SRCA 1TZEE 3N7YA 1AYDA 5AULA 5IBMA 1LUKA 1NRVA 2L4KA 2K79B 1FBVA 1O4FA 1XA6A 1SHBA 3VS2A 2DVJA 2CRHA 2PNBA 3CXLA 4K2RA 2ECDA 3VS5A 2DLZA 4F59A 1A81A 5DC9A 1UUSA 1BG1A 1O45A 1BM2A 2EO6A 3EACA 1O46A 1GHUA 3PQZA 1D4WA 2RORA 2KK6A 5I6VA 1JYQA 3PJPA 1RPYA 1OPLA 3CD3A 1O47A 2BBUA 4GL9E 3HHMB 1QCFA 2CS0A 1FHSA 1O4BA 1BFJA 2GSBA 1AYCA 3ZNIA 2JYQA 4LUEA 5BO4A 4WWQA 2HDVA 2K7AB 1O4QA 1LKLA 3UYOA 3MXYA 1O42A 1Z3KA 2YSXA 1LCKA 5HKZA 1IJRA 1O4OA 1YVHA 2AOBA 4E68A 3VS7A 4K44A 1R1PA 3GQIB 3S8LA 3IN7A 1O4EA 5D0JA 1SPSA 1NZVA 3GXWA 1A1CA 2L3TA 1O49A 3S8NA 1Y1UA 3BUOB 1FU5A 2PTKA 4EY0A 2LNWA 1SPRA 1O48A 2RSYA 3NHNA 2AOAA 1BLJA 2CIAA 2C0TA 3VROA 1GRIA 5GJHA 3VS0A 4EIHA 4XZ0A 3BUXB 3TKZA 2PNAA 2HDXA 1H9OA 2C0OA 2EKXA 3CBLA 1BHHA 4LUDA 2C0IA 1P13A 2EOBA 1BF5A 3VS4A 1FU6A 3PSKA 3VS3A 2CBLA 3VRNA 3N84A 2MRKA 2EYZA 1YVLA 3HIZB 1CSZA 1FYRA 1G83A 2HMHA 3VRQA 1AYAA 1O4NA 1X6CA 3VRRA 2IUGA 1KA7A 5CDWA 1AD5A 1HCTB 2IZVA 4F5AA 2B3OA 1OPKA 2DX0A 2KNOA 1O4IA 1A1EA 1AOTF 2Y1NA 2FO0A 1LKKA 2DM0A 3VS1A 4FL2A 4FL3A 5EELA 4GWFA 1TCEA 5EHRA 3MXCA 1QADA 5EHPA 5EG3B 2EYVA 3EAZA 4ROJA 4JEGA 3IMJA 2PLEA 2RVFA 2VIFA 3BUWB 1FMKA 2XP1A 1O4RA 3PSJA 3T04A 2RMXA 4QSYA 3VS6A 1X0NA 1AOUF 4H34A 3BKBA 3GXXA 2GE9A 2OQ1A 3CWGA 2H5KA 3OB1B 2MRJA 1R1SA 1HCSB 2CI8A 1O4JA 4DGXA 1O4MA 4L1BB 1M61A 1O44A 3MAZA 2EU0A 4X6SA 1AYBA 2MC1A 4M4ZA 4OHIA 1CJ1A 1SHAA 2Y1MA 3WA4A 4K45A 4U1PA 3PLFB 1SKJA 5EEQA 3PFVA 4P9VA 5J3XA 1M27A 3OVEA 1RJAA 2EO3A 1O4PA 3QWYA 2Y3AB 1O43A 1MW4A 5DC4A 1UURA 1JYRA 1LUMA 3BUNB 1Y57A 1OO3A 1BKMA 1KC2A 5DC0B 1F1WA 3UF4A 1D4TA 4E93A 3S9KA 1IS0A 1WQUA 5DF6A 4JE4A 1LCJA 3VRYA 4OHDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4D8K A;  1K9A A;  3KFJ A;  4OHE A;  1BFI A;  3VRP A;  2QMS A;  4U17 A;  3TL0 A;  1AB2 A;  3OV1 A;  1X27 A;  5IBS A;  1BKL A;  1A08 A;  4OHL A;  2MQI A;  2H46 E;  2IUI A;  2CR4 A;  3M7F A;  3IN8 A;  2CI9 A;  1CSY A;  1F2F A;  1OO4 A;  4TZI A;  1BHH B;  3OB2 B;  4F5B A;  1KA6 A;  2LCT A;  4A4C A;  1A1B A;  2PLD A;  1JU5 A;  1RQQ C;  4A4B A;  5AXI A;  2LQW A;  1I3Z A;  1JWO A;  1CWD L;  3BUM B;  2HCK A;  3S8O A;  1O4G A;  2EYY A;  1BMB A;  4JGH A;  1MIL A;  1NZL A;  3K2M A;  1ZFP E;  1O41 A;  2FCI A;  4NWF A;  1LUI A;  2EL8 A;  3US4 A;  4DGP A;  2LQN A;  1BHF A;  3N8M A;  4P9Z A;  5GJI A;  2IUH A;  4K11 A;  2LNX A;  5HKW A;  4FBN A;  3HCK A;  1QG1 E;  1KSW A;  2C9W A;  5HKY A;  3IMD A;  4GPL B;  2AUG A;  1O4C A;  1A1A A;  2YU7 A;  1A09 A;  1O4A A;  1PIC A;  4XZ1 A;  1B47 A;  3QWX X;  2HUW A;  3PS5 A;  1A07 A;  3VGO A;  1O4H A;  1O4L A;  1O4K A;  2MK2 A;  2SHP A;  2DLY A;  2ABL A;  1JYU A;  2H8H A;  1SHD A;  2L6K A;  4H1O A;  3OP0 A;  3C7I A;  3VRZ A;  2DCR A;  1LUN A;  2OZO A;  4NWG A;  1O4D A;  2ETZ A;  1D1Z A;  1CWE A;  1FBZ A;  5KAZ A;  1R1Q A;  4OHH A;  1BLK A;  2SRC A;  1TZE E;  3N7Y A;  1AYD A;  5AUL A;  5IBM A;  1LUK A;  1NRV A;  2L4K A;  2K79 B;  1FBV A;  1O4F A;  1XA6 A;  1SHB A;  3VS2 A;  2DVJ A;  2CRH A;  2PNB A;  3CXL A;  4K2R A;  2ECD A;  3VS5 A;  2DLZ A;  4F59 A;  1A81 A;  5DC9 A;  1UUS A;  1BG1 A;  1O45 A;  1BM2 A;  2EO6 A;  3EAC A;  1O46 A;  1GHU A;  3PQZ A;  1D4W A;  2ROR A;  2KK6 A;  5I6V A;  1JYQ A;  3PJP A;  1RPY A;  1OPL A;  3CD3 A;  1O47 A;  2BBU A;  4GL9 E;  3HHM B;  1QCF A;  2CS0 A;  1FHS A;  1O4B A;  1BFJ A;  2GSB A;  1AYC A;  3ZNI A;  2JYQ A;  4LUE A;  5BO4 A;  4WWQ A;  2HDV A;  2K7A B;  1O4Q A;  1LKL A;  3UYO A;  3MXY A;  1O42 A;  1Z3K A;  2YSX A;  1LCK A;  5HKZ A;  1IJR A;  1O4O A;  1YVH A;  2AOB A;  4E68 A;  3VS7 A;  4K44 A;  1R1P A;  3GQI B;  3S8L A;  3IN7 A;  1O4E A;  5D0J A;  1SPS A;  1NZV A;  3GXW A;  1A1C A;  2L3T A;  1O49 A;  3S8N A;  1Y1U A;  3BUO B;  1FU5 A;  2PTK A;  4EY0 A;  2LNW A;  1SPR A;  1O48 A;  2RSY A;  3NHN A;  2AOA A;  1BLJ A;  2CIA A;  2C0T A;  3VRO A;  1GRI A;  5GJH A;  3VS0 A;  4EIH A;  4XZ0 A;  3BUX B;  3TKZ A;  2PNA A;  2HDX A;  1H9O A;  2C0O A;  2EKX A;  3CBL A;  1BHH A;  4LUD A;  2C0I A;  1P13 A;  2EOB A;  1BF5 A;  3VS4 A;  1FU6 A;  3PSK A;  3VS3 A;  2CBL A;  3VRN A;  3N84 A;  2MRK A;  2EYZ A;  1YVL A;  3HIZ B;  1CSZ A;  1FYR A;  1G83 A;  2HMH A;  3VRQ A;  1AYA A;  1O4N A;  1X6C A;  3VRR A;  2IUG A;  1KA7 A;  5CDW A;  1AD5 A;  1HCT B;  2IZV A;  4F5A A;  2B3O A;  1OPK A;  2DX0 A;  2KNO A;  1O4I A;  1A1E A;  1AOT F;  2Y1N A;  2FO0 A;  1LKK A;  2DM0 A;  3VS1 A;  4FL2 A;  4FL3 A;  5EEL A;  4GWF A;  1TCE A;  5EHR A;  3MXC A;  1QAD A;  5EHP A;  5EG3 B;  2EYV A;  3EAZ A;  4ROJ A;  4JEG A;  3IMJ A;  2PLE A;  2RVF A;  2VIF A;  3BUW B;  1FMK A;  2XP1 A;  1O4R A;  3PSJ A;  3T04 A;  2RMX A;  4QSY A;  3VS6 A;  1X0N A;  1AOU F;  4H34 A;  3BKB A;  3GXX A;  2GE9 A;  2OQ1 A;  3CWG A;  2H5K A;  3OB1 B;  2MRJ A;  1R1S A;  1HCS B;  2CI8 A;  1O4J A;  4DGX A;  1O4M A;  4L1B B;  1M61 A;  1O44 A;  3MAZ A;  2EU0 A;  4X6S A;  1AYB A;  2MC1 A;  4M4Z A;  4OHI A;  1CJ1 A;  1SHA A;  2Y1M A;  3WA4 A;  4K45 A;  4U1P A;  3PLF B;  1SKJ A;  5EEQ A;  3PFV A;  4P9V A;  5J3X A;  1M27 A;  3OVE A;  1RJA A;  2EO3 A;  1O4P A;  3QWY A;  2Y3A B;  1O43 A;  1MW4 A;  5DC4 A;  1UUR A;  1JYR A;  1LUM A;  3BUN B;  1Y57 A;  1OO3 A;  1BKM A;  1KC2 A;  5DC0 B;  1F1W A;  3UF4 A;  1D4T A;  4E93 A;  3S9K A;  1IS0 A;  1WQU A;  5DF6 A;  4JE4 A;  1LCJ A;  3VRY A;  4OHD A; 
#chains in the Genus database with same CATH topology
 4D8K A;  1K9A A;  3KFJ A;  4OHE A;  1BFI A;  3VRP A;  2QMS A;  4U17 A;  3TL0 A;  1AB2 A;  3OV1 A;  1X27 A;  5IBS A;  1BKL A;  1A08 A;  4OHL A;  2MQI A;  2H46 E;  2IUI A;  2CR4 A;  3M7F A;  3IN8 A;  2CI9 A;  1CSY A;  1F2F A;  1OO4 A;  4TZI A;  1BHH B;  3OB2 B;  4F5B A;  1KA6 A;  2LCT A;  4A4C A;  1A1B A;  2PLD A;  1JU5 A;  1RQQ C;  2KGY A;  4A4B A;  5AXI A;  2LQW A;  1I3Z A;  1JWO A;  1CWD L;  3BUM B;  2HCK A;  3S8O A;  1O4G A;  2EYY A;  1BMB A;  4JGH A;  1MIL A;  1NZL A;  3K2M A;  1ZFP E;  1O41 A;  2FCI A;  4NWF A;  1LUI A;  2EL8 A;  3K2T A;  3US4 A;  4DGP A;  2LQN A;  1BHF A;  3N8M A;  4P9Z A;  5GJI A;  2IUH A;  4K11 A;  2LNX A;  5HKW A;  4FBN A;  3HCK A;  1QG1 E;  1KSW A;  2C9W A;  5HKY A;  3IMD A;  4GPL B;  2AUG A;  1O4C A;  1A1A A;  2YU7 A;  1A09 A;  1O4A A;  1PIC A;  4XZ1 A;  1B47 A;  3QWX X;  2HUW A;  3PS5 A;  1A07 A;  3VGO A;  1O4H A;  1O4L A;  1O4K A;  2MK2 A;  2SHP A;  2DLY A;  2ABL A;  1JYU A;  2H8H A;  1SHD A;  2L6K A;  4H1O A;  3OP0 A;  3C7I A;  3VRZ A;  2DCR A;  1LUN A;  2OZO A;  4NWG A;  1O4D A;  2ETZ A;  1D1Z A;  1CWE A;  1FBZ A;  5KAZ A;  1R1Q A;  4OHH A;  1BLK A;  2SRC A;  1TZE E;  3N7Y A;  1AYD A;  5AUL A;  5IBM A;  1LUK A;  1NRV A;  2L4K A;  2K79 B;  1FBV A;  1O4F A;  1XA6 A;  1SHB A;  3VS2 A;  2DVJ A;  2CRH A;  2PNB A;  3CXL A;  4K2R A;  2ECD A;  3VS5 A;  2DLZ A;  4F59 A;  1A81 A;  5DC9 A;  1UUS A;  1BG1 A;  1O45 A;  1BM2 A;  2EO6 A;  3EAC A;  1O46 A;  1GHU A;  3PQZ A;  1D4W A;  2ROR A;  2KK6 A;  5I6V A;  1JYQ A;  3PJP A;  2LRA A;  1RPY A;  1OPL A;  3CD3 A;  1O47 A;  2BBU A;  4GL9 E;  3HHM B;  1QCF A;  2CS0 A;  1FHS A;  1O4B A;  1BFJ A;  2GSB A;  1AYC A;  3ZNI A;  2JYQ A;  4LUE A;  5BO4 A;  4WWQ A;  2HDV A;  2K7A B;  1O4Q A;  1LKL A;  3UYO A;  3MXY A;  1O42 A;  1Z3K A;  2YSX A;  1LCK A;  5HKZ A;  1IJR A;  1O4O A;  1YVH A;  2AOB A;  4E68 A;  3VS7 A;  4K44 A;  1R1P A;  3GQI B;  3S8L A;  3IN7 A;  1O4E A;  5D0J A;  1SPS A;  1NZV A;  3GXW A;  1A1C A;  2L3T A;  1O49 A;  3S8N A;  1Y1U A;  3BUO B;  1FU5 A;  2PTK A;  4EY0 A;  2LNW A;  1SPR A;  1O48 A;  2RSY A;  3NHN A;  2AOA A;  1BLJ A;  2CIA A;  2C0T A;  3VRO A;  1GRI A;  5GJH A;  3VS0 A;  4EIH A;  4XZ0 A;  3BUX B;  3TKZ A;  2PNA A;  2HDX A;  1H9O A;  2C0O A;  2EKX A;  3CBL A;  1BHH A;  4LUD A;  2C0I A;  1P13 A;  2EOB A;  1BF5 A;  3VS4 A;  1FU6 A;  3PSK A;  3VS3 A;  2CBL A;  3VRN A;  3N84 A;  2MRK A;  2EYZ A;  1YVL A;  3HIZ B;  1CSZ A;  1FYR A;  1G83 A;  2HMH A;  3VRQ A;  1AYA A;  1O4N A;  1X6C A;  3LYV A;  3VRR A;  2IUG A;  1KA7 A;  5CDW A;  1AD5 A;  1HCT B;  2IZV A;  4F5A A;  2B3O A;  1OPK A;  2DX0 A;  2KNO A;  1O4I A;  1A1E A;  1AOT F;  2Y1N A;  2FO0 A;  1LKK A;  2DM0 A;  3VS1 A;  4FL2 A;  4FL3 A;  5EEL A;  4GWF A;  1TCE A;  5EHR A;  3MXC A;  1QAD A;  5EHP A;  5EG3 B;  2EYV A;  3EAZ A;  4ROJ A;  4JEG A;  3IMJ A;  2PLE A;  2RVF A;  2VIF A;  3BUW B;  1FMK A;  2XP1 A;  1O4R A;  3PSJ A;  3T04 A;  2RMX A;  4QSY A;  3VS6 A;  1X0N A;  1AOU F;  4H34 A;  3BKB A;  3GXX A;  2GE9 A;  2OQ1 A;  3CWG A;  2H5K A;  3OB1 B;  2MRJ A;  1R1S A;  1HCS B;  2CI8 A;  1O4J A;  4DGX A;  1O4M A;  4L1B B;  1M61 A;  1O44 A;  3MAZ A;  2EU0 A;  4X6S A;  1AYB A;  2MC1 A;  4M4Z A;  4OHI A;  1CJ1 A;  1SHA A;  2Y1M A;  3WA4 A;  4K45 A;  4U1P A;  3PLF B;  1SKJ A;  5EEQ A;  3PFV A;  4P9V A;  5J3X A;  1M27 A;  3OVE A;  1RJA A;  2EO3 A;  1O4P A;  3QWY A;  2Y3A B;  1O43 A;  1MW4 A;  5DC4 A;  1UUR A;  1JYR A;  1LUM A;  3BUN B;  1Y57 A;  1OO3 A;  1BKM A;  1KC2 A;  5DC0 B;  1F1W A;  3UF4 A;  1D4T A;  4E93 A;  3S9K A;  1IS0 A;  1WQU A;  5DF6 A;  4JE4 A;  1LCJ A;  3VRY A;  4OHD A; 
#chains in the Genus database with same CATH homology
 4D8K A;  1K9A A;  3KFJ A;  4OHE A;  1BFI A;  3VRP A;  2QMS A;  4U17 A;  3TL0 A;  1AB2 A;  3OV1 A;  1X27 A;  5IBS A;  1BKL A;  1A08 A;  4OHL A;  2MQI A;  2H46 E;  2IUI A;  2CR4 A;  3M7F A;  3IN8 A;  2CI9 A;  1CSY A;  1F2F A;  1OO4 A;  4TZI A;  1BHH B;  3OB2 B;  4F5B A;  1KA6 A;  2LCT A;  4A4C A;  1A1B A;  2PLD A;  1JU5 A;  1RQQ C;  4A4B A;  5AXI A;  2LQW A;  1I3Z A;  1JWO A;  1CWD L;  3BUM B;  2HCK A;  3S8O A;  1O4G A;  2EYY A;  1BMB A;  4JGH A;  1MIL A;  1NZL A;  3K2M A;  1ZFP E;  1O41 A;  2FCI A;  4NWF A;  1LUI A;  2EL8 A;  3US4 A;  4DGP A;  2LQN A;  1BHF A;  3N8M A;  4P9Z A;  5GJI A;  2IUH A;  4K11 A;  2LNX A;  5HKW A;  4FBN A;  3HCK A;  1QG1 E;  1KSW A;  2C9W A;  5HKY A;  3IMD A;  4GPL B;  2AUG A;  1O4C A;  1A1A A;  2YU7 A;  1A09 A;  1O4A A;  1PIC A;  4XZ1 A;  1B47 A;  3QWX X;  2HUW A;  3PS5 A;  1A07 A;  3VGO A;  1O4H A;  1O4L A;  1O4K A;  2MK2 A;  2SHP A;  2DLY A;  2ABL A;  1JYU A;  2H8H A;  1SHD A;  2L6K A;  4H1O A;  3OP0 A;  3C7I A;  3VRZ A;  2DCR A;  1LUN A;  2OZO A;  4NWG A;  1O4D A;  2ETZ A;  1D1Z A;  1CWE A;  1FBZ A;  5KAZ A;  1R1Q A;  4OHH A;  1BLK A;  2SRC A;  1TZE E;  3N7Y A;  1AYD A;  5AUL A;  5IBM A;  1LUK A;  1NRV A;  2L4K A;  2K79 B;  1FBV A;  1O4F A;  1XA6 A;  1SHB A;  3VS2 A;  2DVJ A;  2CRH A;  2PNB A;  3CXL A;  4K2R A;  2ECD A;  3VS5 A;  2DLZ A;  4F59 A;  1A81 A;  5DC9 A;  1UUS A;  1BG1 A;  1O45 A;  1BM2 A;  2EO6 A;  3EAC A;  1O46 A;  1GHU A;  3PQZ A;  1D4W A;  2ROR A;  2KK6 A;  5I6V A;  1JYQ A;  3PJP A;  1RPY A;  1OPL A;  3CD3 A;  1O47 A;  2BBU A;  4GL9 E;  3HHM B;  1QCF A;  2CS0 A;  1FHS A;  1O4B A;  1BFJ A;  2GSB A;  1AYC A;  3ZNI A;  2JYQ A;  4LUE A;  5BO4 A;  4WWQ A;  2HDV A;  2K7A B;  1O4Q A;  1LKL A;  3UYO A;  3MXY A;  1O42 A;  1Z3K A;  2YSX A;  1LCK A;  5HKZ A;  1IJR A;  1O4O A;  1YVH A;  2AOB A;  4E68 A;  3VS7 A;  4K44 A;  1R1P A;  3GQI B;  3S8L A;  3IN7 A;  1O4E A;  5D0J A;  1SPS A;  1NZV A;  3GXW A;  1A1C A;  2L3T A;  1O49 A;  3S8N A;  1Y1U A;  3BUO B;  1FU5 A;  2PTK A;  4EY0 A;  2LNW A;  1SPR A;  1O48 A;  2RSY A;  3NHN A;  2AOA A;  1BLJ A;  2CIA A;  2C0T A;  3VRO A;  1GRI A;  5GJH A;  3VS0 A;  4EIH A;  4XZ0 A;  3BUX B;  3TKZ A;  2PNA A;  2HDX A;  1H9O A;  2C0O A;  2EKX A;  3CBL A;  1BHH A;  4LUD A;  2C0I A;  1P13 A;  2EOB A;  1BF5 A;  3VS4 A;  1FU6 A;  3PSK A;  3VS3 A;  2CBL A;  3VRN A;  3N84 A;  2MRK A;  2EYZ A;  1YVL A;  3HIZ B;  1CSZ A;  1FYR A;  1G83 A;  2HMH A;  3VRQ A;  1AYA A;  1O4N A;  1X6C A;  3VRR A;  2IUG A;  1KA7 A;  5CDW A;  1AD5 A;  1HCT B;  2IZV A;  4F5A A;  2B3O A;  1OPK A;  2DX0 A;  2KNO A;  1O4I A;  1A1E A;  1AOT F;  2Y1N A;  2FO0 A;  1LKK A;  2DM0 A;  3VS1 A;  4FL2 A;  4FL3 A;  5EEL A;  4GWF A;  1TCE A;  5EHR A;  3MXC A;  1QAD A;  5EHP A;  5EG3 B;  2EYV A;  3EAZ A;  4ROJ A;  4JEG A;  3IMJ A;  2PLE A;  2RVF A;  2VIF A;  3BUW B;  1FMK A;  2XP1 A;  1O4R A;  3PSJ A;  3T04 A;  2RMX A;  4QSY A;  3VS6 A;  1X0N A;  1AOU F;  4H34 A;  3BKB A;  3GXX A;  2GE9 A;  2OQ1 A;  3CWG A;  2H5K A;  3OB1 B;  2MRJ A;  1R1S A;  1HCS B;  2CI8 A;  1O4J A;  4DGX A;  1O4M A;  4L1B B;  1M61 A;  1O44 A;  3MAZ A;  2EU0 A;  4X6S A;  1AYB A;  2MC1 A;  4M4Z A;  4OHI A;  1CJ1 A;  1SHA A;  2Y1M A;  3WA4 A;  4K45 A;  4U1P A;  3PLF B;  1SKJ A;  5EEQ A;  3PFV A;  4P9V A;  5J3X A;  1M27 A;  3OVE A;  1RJA A;  2EO3 A;  1O4P A;  3QWY A;  2Y3A B;  1O43 A;  1MW4 A;  5DC4 A;  1UUR A;  1JYR A;  1LUM A;  3BUN B;  1Y57 A;  1OO3 A;  1BKM A;  1KC2 A;  5DC0 B;  1F1W A;  3UF4 A;  1D4T A;  4E93 A;  3S9K A;  1IS0 A;  1WQU A;  5DF6 A;  4JE4 A;  1LCJ A;  3VRY A;  4OHD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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