4K45A

Auto-inhibition and phosphorylation-induced activation of plc-gamma isozymes
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
102
structure length
102
Chain Sequence
QAESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Rattus norvegicus
molecule keywords 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ga
total genus 26
structure length 102
sequence length 102
ec nomenclature ec 3.1.4.11: Phosphoinositide phospholipase C.
pdb deposition date 2013-04-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00017 SH2 SH2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.505.10 Alpha Beta 2-Layer Sandwich SHC Adaptor Protein SH2 domain 4k45A00
2Y1NA 1BFIA 3MXYA 1OPKA 1CSZA 1TZEE 5AXIA 2AOAA 1SPSA 4OHIA 5HKZA 2FCIA 1O45A 1ZFPE 2IUGA 1BLKA 2CIAA 1KA6A 2JYQA 1R1QA 1SKJA 3PS5A 4GL9E 5D0JA 4K45A 3PQZA 1GRIA 1KC2A 1O4PA 1SHDA 3IN7A 4E93A 5I6VA 1A09A 2MRJA 1HCTB 1TCEA 1RQQC 1BM2A 3VS6A 3K2MA 1NRVA 3ZNIA 2YU7A 2KK6A 2C0TA 1FBZA 4GWFA 1D4TA 1A1AA 1JYRA 4FL3A 3GQIB 1O4FA 3N8MA 2EOBA 2EL8A 3PFVA 4L1BB 1JU5A 1LUKA 2EYZA 1BLJA 4P9VA 2Y3AB 3WA4A 1O4JA 1YVLA 2Y1MA 2RSYA 1JYUA 4K11A 4H34A 2EYYA 2XP1A 2YSXA 1X6CA 3VS4A 5EG3B 2CI8A 5EHPA 1AYBA 3BUMB 5AULA 1XA6A 2B3OA 4OHLA 3N84A 2CRHA 2IZVA 3M7FA 2LNXA 2ABLA 1BKLA 1M27A 1OO3A 1OPLA 1AYDA 4K2RA 5KAZA 1LKLA 5GJIA 1JWOA 3MXCA 3T04A 3CBLA 2PTKA 3VS3A 2GE9A 4TZIA 2L4KA 2LQNA 1R1PA 3GXWA 3IN8A 3S8OA 1G83A 4D8KA 5IBSA 1M61A 4FBNA 2LQWA 1CSYA 1FU5A 3VS1A 1BHHB 1O4HA 4K44A 2EO6A 3UYOA 1X27A 3IMJA 3BUOB 2AOBA 3N7YA 2RORA 2QMSA 2DCRA 2IUIA 3CWGA 2IUHA 4U17A 1O4EA 2CBLA 1BF5A 1O4OA 3VRQA 1LUIA 1BHFA 3CD3A 5IBMA 2PLDA 2HDXA 1O46A 1Z3KA 4NWGA 1O43A 1CJ1A 1O49A 1O4BA 1SHAA 4XZ0A 4JE4A 1QADA 4NWFA 1O4AA 3OB1B 4F59A 1O4LA 2MC1A 4A4BA 4WWQA 2HCKA 2K79B 4DGXA 1F1WA 3OVEA 2MK2A 3S8LA 2GSBA 4M4ZA 3BUWB 2H5KA 5DC4A 1O4NA 1MILA 3VROA 2MQIA 2EKXA 3PLFB 1O4IA 1LKKA 3BKBA 1PICA 1CWDL 4JGHA 3VRYA 1LCJA 1O4KA 2HDVA 4DGPA 3OV1A 2EO3A 1F2FA 1LUMA 2C0OA 3EACA 4E68A 3QWXX 3OP0A 1RPYA 4QSYA 1WQUA 1O4DA 1QG1E 1A07A 1O44A 4OHEA 1FHSA 1IS0A 3GXXA 4XZ1A 2AUGA 2C9WA 3VRRA 3VS7A 1O4MA 2EYVA 2EU0A 3C7IA 1O4CA 2DM0A 5EELA 1A1BA 1BG1A 1QCFA 1OO4A 1AYAA 1NZLA 1SHBA 1AYCA 1O47A 1I3ZA 1AB2A 2PNBA 1O48A 1SPRA 1O4RA 2MRKA 2VIFA 3VS5A 2CR4A 1D4WA 3VRPA 2ECDA 2HUWA 2PNAA 3QWYA 4F5AA 1P13A 4GPLB 4EY0A 1BHHA 1BFJA 2H8HA 1H9OA 1KSWA 2RVFA 2CI9A 1BMBA 2LCTA 2OZOA 2RMXA 2L6KA 5BO4A 1A1CA 1LCKA 2PLEA 3KFJA 1BKMA 2C0IA 1CWEA 2DX0A 1O4GA 3HIZB 4OHDA 3MAZA 3IMDA 1AOTF 1AOUF 1JYQA 2DVJA 3VS0A 2SRCA 2LNWA 1R1SA 1UUSA 2L3TA 4U1PA 3PJPA 1MW4A 5DC0B 1FBVA 1K9AA 3PSJA 2DLYA 1AD5A 2FO0A 1D1ZA 5DF6A 1FMKA 1A08A 4LUDA 5HKYA 2K7AB 5CDWA 1RJAA 1LUNA 2BBUA 1A81A 4ROJA 1HCSB 1KA7A 1Y57A 2SHPA 2KNOA 1A1EA 1IJRA 3OB2B 4A4CA 3VS2A 3PSKA 5EEQA 3EAZA 1O41A 1YVHA 4FL2A 1FYRA 2CS0A 3S9KA 3VRZA 1B47A 1O42A 4LUEA 2ETZA 3HHMB 4X6SA 3TL0A 5HKWA 1Y1UA 1O4QA 4H1OA 3TKZA 3VRNA 3UF4A 3BUNB 3US4A 2DLZA 3CXLA 4EIHA 3S8NA 1X0NA 3HCKA 1FU6A 5J3XA 4JEGA 1NZVA 2OQ1A 4P9ZA 1UURA 5EHRA 3VGOA 3NHNA 2H46E 3BUXB 4OHHA 4F5BA 1GHUA 5DC9A 5GJHA 2HMHA
chains in the Genus database with same CATH superfamily
2Y1NA 1BFIA 3MXYA 1OPKA 1CSZA 1TZEE 5AXIA 2AOAA 1SPSA 4OHIA 5HKZA 2FCIA 1O45A 1ZFPE 2IUGA 1BLKA 2CIAA 1KA6A 2JYQA 1R1QA 1SKJA 3PS5A 4GL9E 5D0JA 4K45A 3PQZA 1GRIA 1KC2A 1O4PA 1SHDA 3IN7A 4E93A 5I6VA 1A09A 2MRJA 1HCTB 1TCEA 1RQQC 1BM2A 3VS6A 3K2MA 1NRVA 3ZNIA 2YU7A 2KK6A 2C0TA 1FBZA 4GWFA 1D4TA 1A1AA 1JYRA 4FL3A 3LYVA 3GQIB 1O4FA 3N8MA 2EOBA 2EL8A 3PFVA 4L1BB 1JU5A 1LUKA 2EYZA 1BLJA 4P9VA 2Y3AB 3WA4A 1O4JA 1YVLA 2Y1MA 2RSYA 1JYUA 4K11A 4H34A 2EYYA 2XP1A 2YSXA 1X6CA 3VS4A 5EG3B 2CI8A 5EHPA 1AYBA 3BUMB 5AULA 1XA6A 2B3OA 4OHLA 3N84A 2CRHA 2IZVA 3M7FA 2LNXA 2ABLA 1BKLA 2KGYA 1M27A 1OO3A 1OPLA 1AYDA 4K2RA 5KAZA 1LKLA 5GJIA 1JWOA 3MXCA 3T04A 3CBLA 2PTKA 3VS3A 2GE9A 4TZIA 2L4KA 2LQNA 1R1PA 3GXWA 3IN8A 3S8OA 1G83A 4D8KA 5IBSA 1M61A 4FBNA 2LQWA 1CSYA 1FU5A 3VS1A 1BHHB 1O4HA 4K44A 2EO6A 3UYOA 1X27A 3IMJA 3BUOB 2AOBA 3N7YA 2RORA 2QMSA 2DCRA 2IUIA 3CWGA 2IUHA 4U17A 1O4EA 2CBLA 1BF5A 1O4OA 3VRQA 1LUIA 1BHFA 3CD3A 5IBMA 2PLDA 2HDXA 1O46A 1Z3KA 2LRAA 1O43A 4NWGA 1CJ1A 1O49A 1O4BA 1SHAA 4XZ0A 4JE4A 1QADA 4NWFA 1O4AA 3OB1B 4F59A 1O4LA 2MC1A 4A4BA 4WWQA 2HCKA 2K79B 4DGXA 1F1WA 3OVEA 2MK2A 3S8LA 2GSBA 4M4ZA 3BUWB 2H5KA 5DC4A 1O4NA 1MILA 3VROA 2MQIA 2EKXA 3PLFB 1O4IA 1LKKA 3BKBA 1PICA 1CWDL 4JGHA 3VRYA 1LCJA 1O4KA 2HDVA 4DGPA 3OV1A 2EO3A 1F2FA 1LUMA 2C0OA 3EACA 4E68A 3QWXX 3OP0A 1RPYA 4QSYA 1WQUA 1O4DA 1QG1E 1A07A 1O44A 4OHEA 1FHSA 1IS0A 3GXXA 4XZ1A 2AUGA 2C9WA 3VRRA 3VS7A 1O4MA 2EYVA 2EU0A 3C7IA 3K2TA 1O4CA 2DM0A 5EELA 1A1BA 1BG1A 1QCFA 1OO4A 1AYAA 1NZLA 1SHBA 1AYCA 1O47A 1I3ZA 1AB2A 2PNBA 1O48A 1SPRA 1O4RA 2MRKA 2VIFA 3VS5A 2CR4A 1D4WA 3VRPA 2ECDA 2HUWA 2PNAA 3QWYA 4F5AA 1P13A 4GPLB 4EY0A 1BHHA 1BFJA 2H8HA 1H9OA 1KSWA 2RVFA 2CI9A 1BMBA 2LCTA 2OZOA 2RMXA 2L6KA 5BO4A 1A1CA 1LCKA 2PLEA 3KFJA 1BKMA 2C0IA 1CWEA 2DX0A 1O4GA 3HIZB 4OHDA 3MAZA 3IMDA 1AOTF 1AOUF 1JYQA 2DVJA 3VS0A 2SRCA 2LNWA 1R1SA 1UUSA 2L3TA 4U1PA 3PJPA 1MW4A 5DC0B 1FBVA 1K9AA 3PSJA 2DLYA 1AD5A 2FO0A 1D1ZA 5DF6A 1FMKA 1A08A 4LUDA 5HKYA 2K7AB 5CDWA 1RJAA 1LUNA 2BBUA 1A81A 4ROJA 1HCSB 1KA7A 1Y57A 2SHPA 2KNOA 1A1EA 1IJRA 3OB2B 4A4CA 3VS2A 3PSKA 5EEQA 3EAZA 1O41A 1YVHA 4FL2A 1FYRA 2CS0A 3S9KA 3VRZA 1B47A 1O42A 4LUEA 2ETZA 3HHMB 4X6SA 3TL0A 5HKWA 1Y1UA 1O4QA 4H1OA 3TKZA 3VRNA 3UF4A 3BUNB 3US4A 2DLZA 3CXLA 4EIHA 3S8NA 1X0NA 3HCKA 1FU6A 5J3XA 4JEGA 1NZVA 2OQ1A 4P9ZA 1UURA 5EHRA 3VGOA 3NHNA 2H46E 3BUXB 4OHHA 4F5BA 1GHUA 5DC9A 5GJHA 2HMHA
chains in the Genus database with same CATH topology
2Y1NA 1BFIA 3MXYA 1OPKA 1CSZA 1TZEE 5AXIA 2AOAA 1SPSA 4OHIA 5HKZA 2FCIA 1O45A 1ZFPE 2IUGA 1BLKA 2CIAA 1KA6A 2JYQA 1R1QA 1SKJA 3PS5A 4GL9E 5D0JA 4K45A 3PQZA 1GRIA 1KC2A 1O4PA 1SHDA 3IN7A 4E93A 5I6VA 1A09A 2MRJA 1HCTB 1TCEA 1RQQC 1BM2A 3VS6A 3K2MA 1NRVA 3ZNIA 2YU7A 2KK6A 2C0TA 1FBZA 4GWFA 1D4TA 1A1AA 1JYRA 4FL3A 3GQIB 1O4FA 3N8MA 2EOBA 2EL8A 3PFVA 4L1BB 1JU5A 1LUKA 2EYZA 1BLJA 4P9VA 2Y3AB 3WA4A 1O4JA 1YVLA 2Y1MA 2RSYA 1JYUA 4K11A 4H34A 2EYYA 2XP1A 2YSXA 1X6CA 3VS4A 5EG3B 2CI8A 5EHPA 1AYBA 3BUMB 5AULA 1XA6A 2B3OA 4OHLA 3N84A 2CRHA 2IZVA 3M7FA 2LNXA 2ABLA 1BKLA 1M27A 1OO3A 1OPLA 1AYDA 4K2RA 5KAZA 1LKLA 5GJIA 1JWOA 3MXCA 3T04A 3CBLA 2PTKA 3VS3A 2GE9A 4TZIA 2L4KA 2LQNA 1R1PA 3GXWA 3IN8A 3S8OA 1G83A 4D8KA 5IBSA 1M61A 4FBNA 2LQWA 1CSYA 1FU5A 3VS1A 1BHHB 1O4HA 4K44A 2EO6A 3UYOA 1X27A 3IMJA 3BUOB 2AOBA 3N7YA 2RORA 2QMSA 2DCRA 2IUIA 3CWGA 2IUHA 4U17A 1O4EA 2CBLA 1BF5A 1O4OA 3VRQA 1LUIA 1BHFA 3CD3A 5IBMA 2PLDA 2HDXA 1O46A 1Z3KA 4NWGA 1O43A 1CJ1A 1O49A 1O4BA 1SHAA 4XZ0A 4JE4A 1QADA 4NWFA 1O4AA 3OB1B 4F59A 1O4LA 2MC1A 4A4BA 4WWQA 2HCKA 2K79B 4DGXA 1F1WA 3OVEA 2MK2A 3S8LA 2GSBA 4M4ZA 3BUWB 2H5KA 5DC4A 1O4NA 1MILA 3VROA 2MQIA 2EKXA 3PLFB 1O4IA 1LKKA 3BKBA 1PICA 1CWDL 4JGHA 3VRYA 1LCJA 1O4KA 2HDVA 4DGPA 3OV1A 2EO3A 1F2FA 1LUMA 2C0OA 3EACA 4E68A 3QWXX 3OP0A 1RPYA 4QSYA 1WQUA 1O4DA 1QG1E 1A07A 1O44A 4OHEA 1FHSA 1IS0A 3GXXA 4XZ1A 2AUGA 2C9WA 3VRRA 3VS7A 1O4MA 2EYVA 2EU0A 3C7IA 1O4CA 2DM0A 5EELA 1A1BA 1BG1A 1QCFA 1OO4A 1AYAA 1NZLA 1SHBA 1AYCA 1O47A 1I3ZA 1AB2A 2PNBA 1O48A 1SPRA 1O4RA 2MRKA 2VIFA 3VS5A 2CR4A 1D4WA 3VRPA 2ECDA 2HUWA 2PNAA 3QWYA 4F5AA 1P13A 4GPLB 4EY0A 1BHHA 1BFJA 2H8HA 1H9OA 1KSWA 2RVFA 2CI9A 1BMBA 2LCTA 2OZOA 2RMXA 2L6KA 5BO4A 1A1CA 1LCKA 2PLEA 3KFJA 1BKMA 2C0IA 1CWEA 2DX0A 1O4GA 3HIZB 4OHDA 3MAZA 3IMDA 1AOTF 1AOUF 1JYQA 2DVJA 3VS0A 2SRCA 2LNWA 1R1SA 1UUSA 2L3TA 4U1PA 3PJPA 1MW4A 5DC0B 1FBVA 1K9AA 3PSJA 2DLYA 1AD5A 2FO0A 1D1ZA 5DF6A 1FMKA 1A08A 4LUDA 5HKYA 2K7AB 5CDWA 1RJAA 1LUNA 2BBUA 1A81A 4ROJA 1HCSB 1KA7A 1Y57A 2SHPA 2KNOA 1A1EA 1IJRA 3OB2B 4A4CA 3VS2A 3PSKA 5EEQA 3EAZA 1O41A 1YVHA 4FL2A 1FYRA 2CS0A 3S9KA 3VRZA 1B47A 1O42A 4LUEA 2ETZA 3HHMB 4X6SA 3TL0A 5HKWA 1Y1UA 1O4QA 4H1OA 3TKZA 3VRNA 3UF4A 3BUNB 3US4A 2DLZA 3CXLA 4EIHA 3S8NA 1X0NA 3HCKA 1FU6A 5J3XA 4JEGA 1NZVA 2OQ1A 4P9ZA 1UURA 5EHRA 3VGOA 3NHNA 2H46E 3BUXB 4OHHA 4F5BA 1GHUA 5DC9A 5GJHA 2HMHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Y1N A;  1BFI A;  3MXY A;  1OPK A;  1CSZ A;  1TZE E;  5AXI A;  2AOA A;  1SPS A;  4OHI A;  5HKZ A;  2FCI A;  1O45 A;  1ZFP E;  2IUG A;  1BLK A;  2CIA A;  1KA6 A;  2JYQ A;  1R1Q A;  1SKJ A;  3PS5 A;  4GL9 E;  5D0J A;  4K45 A;  3PQZ A;  1GRI A;  1KC2 A;  1O4P A;  1SHD A;  3IN7 A;  4E93 A;  5I6V A;  1A09 A;  2MRJ A;  1HCT B;  1TCE A;  1RQQ C;  1BM2 A;  3VS6 A;  3K2M A;  1NRV A;  3ZNI A;  2YU7 A;  2KK6 A;  2C0T A;  1FBZ A;  4GWF A;  1D4T A;  1A1A A;  1JYR A;  4FL3 A;  3GQI B;  1O4F A;  3N8M A;  2EOB A;  2EL8 A;  3PFV A;  4L1B B;  1JU5 A;  1LUK A;  2EYZ A;  1BLJ A;  4P9V A;  2Y3A B;  3WA4 A;  1O4J A;  1YVL A;  2Y1M A;  2RSY A;  1JYU A;  4K11 A;  4H34 A;  2EYY A;  2XP1 A;  2YSX A;  1X6C A;  3VS4 A;  5EG3 B;  2CI8 A;  5EHP A;  1AYB A;  3BUM B;  5AUL A;  1XA6 A;  2B3O A;  4OHL A;  3N84 A;  2CRH A;  2IZV A;  3M7F A;  2LNX A;  2ABL A;  1BKL A;  1M27 A;  1OO3 A;  1OPL A;  1AYD A;  4K2R A;  5KAZ A;  1LKL A;  5GJI A;  1JWO A;  3MXC A;  3T04 A;  3CBL A;  2PTK A;  3VS3 A;  2GE9 A;  4TZI A;  2L4K A;  2LQN A;  1R1P A;  3GXW A;  3IN8 A;  3S8O A;  1G83 A;  4D8K A;  5IBS A;  1M61 A;  4FBN A;  2LQW A;  1CSY A;  1FU5 A;  3VS1 A;  1BHH B;  1O4H A;  4K44 A;  2EO6 A;  3UYO A;  1X27 A;  3IMJ A;  3BUO B;  2AOB A;  3N7Y A;  2ROR A;  2QMS A;  2DCR A;  2IUI A;  3CWG A;  2IUH A;  4U17 A;  1O4E A;  2CBL A;  1BF5 A;  1O4O A;  3VRQ A;  1LUI A;  1BHF A;  3CD3 A;  5IBM A;  2PLD A;  2HDX A;  1O46 A;  1Z3K A;  4NWG A;  1O43 A;  1CJ1 A;  1O49 A;  1O4B A;  1SHA A;  4XZ0 A;  4JE4 A;  1QAD A;  4NWF A;  1O4A A;  3OB1 B;  4F59 A;  1O4L A;  2MC1 A;  4A4B A;  4WWQ A;  2HCK A;  2K79 B;  4DGX A;  1F1W A;  3OVE A;  2MK2 A;  3S8L A;  2GSB A;  4M4Z A;  3BUW B;  2H5K A;  5DC4 A;  1O4N A;  1MIL A;  3VRO A;  2MQI A;  2EKX A;  3PLF B;  1O4I A;  1LKK A;  3BKB A;  1PIC A;  1CWD L;  4JGH A;  3VRY A;  1LCJ A;  1O4K A;  2HDV A;  4DGP A;  3OV1 A;  2EO3 A;  1F2F A;  1LUM A;  2C0O A;  3EAC A;  4E68 A;  3QWX X;  3OP0 A;  1RPY A;  4QSY A;  1WQU A;  1O4D A;  1QG1 E;  1A07 A;  1O44 A;  4OHE A;  1FHS A;  1IS0 A;  3GXX A;  4XZ1 A;  2AUG A;  2C9W A;  3VRR A;  3VS7 A;  1O4M A;  2EYV A;  2EU0 A;  3C7I A;  1O4C A;  2DM0 A;  5EEL A;  1A1B A;  1BG1 A;  1QCF A;  1OO4 A;  1AYA A;  1NZL A;  1SHB A;  1AYC A;  1O47 A;  1I3Z A;  1AB2 A;  2PNB A;  1O48 A;  1SPR A;  1O4R A;  2MRK A;  2VIF A;  3VS5 A;  2CR4 A;  1D4W A;  3VRP A;  2ECD A;  2HUW A;  2PNA A;  3QWY A;  4F5A A;  1P13 A;  4GPL B;  4EY0 A;  1BHH A;  1BFJ A;  2H8H A;  1H9O A;  1KSW A;  2RVF A;  2CI9 A;  1BMB A;  2LCT A;  2OZO A;  2RMX A;  2L6K A;  5BO4 A;  1A1C A;  1LCK A;  2PLE A;  3KFJ A;  1BKM A;  2C0I A;  1CWE A;  2DX0 A;  1O4G A;  3HIZ B;  4OHD A;  3MAZ A;  3IMD A;  1AOT F;  1AOU F;  1JYQ A;  2DVJ A;  3VS0 A;  2SRC A;  2LNW A;  1R1S A;  1UUS A;  2L3T A;  4U1P A;  3PJP A;  1MW4 A;  5DC0 B;  1FBV A;  1K9A A;  3PSJ A;  2DLY A;  1AD5 A;  2FO0 A;  1D1Z A;  5DF6 A;  1FMK A;  1A08 A;  4LUD A;  5HKY A;  2K7A B;  5CDW A;  1RJA A;  1LUN A;  2BBU A;  1A81 A;  4ROJ A;  1HCS B;  1KA7 A;  1Y57 A;  2SHP A;  2KNO A;  1A1E A;  1IJR A;  3OB2 B;  4A4C A;  3VS2 A;  3PSK A;  5EEQ A;  3EAZ A;  1O41 A;  1YVH A;  4FL2 A;  1FYR A;  2CS0 A;  3S9K A;  3VRZ A;  1B47 A;  1O42 A;  4LUE A;  2ETZ A;  3HHM B;  4X6S A;  3TL0 A;  5HKW A;  1Y1U A;  1O4Q A;  4H1O A;  3TKZ A;  3VRN A;  3UF4 A;  3BUN B;  3US4 A;  2DLZ A;  3CXL A;  4EIH A;  3S8N A;  1X0N A;  3HCK A;  1FU6 A;  5J3X A;  4JEG A;  1NZV A;  2OQ1 A;  4P9Z A;  1UUR A;  5EHR A;  3VGO A;  3NHN A;  2H46 E;  3BUX B;  4OHH A;  4F5B A;  1GHU A;  5DC9 A;  5GJH A;  2HMH A; 
#chains in the Genus database with same CATH topology
 2Y1N A;  1BFI A;  3MXY A;  1OPK A;  1CSZ A;  1TZE E;  5AXI A;  2AOA A;  1SPS A;  4OHI A;  5HKZ A;  2FCI A;  1O45 A;  1ZFP E;  2IUG A;  1BLK A;  2CIA A;  1KA6 A;  2JYQ A;  1R1Q A;  1SKJ A;  3PS5 A;  4GL9 E;  5D0J A;  4K45 A;  3PQZ A;  1GRI A;  1KC2 A;  1O4P A;  1SHD A;  3IN7 A;  4E93 A;  5I6V A;  1A09 A;  2MRJ A;  1HCT B;  1TCE A;  1RQQ C;  1BM2 A;  3VS6 A;  3K2M A;  1NRV A;  3ZNI A;  2YU7 A;  2KK6 A;  2C0T A;  1FBZ A;  4GWF A;  1D4T A;  1A1A A;  1JYR A;  4FL3 A;  3LYV A;  3GQI B;  1O4F A;  3N8M A;  2EOB A;  2EL8 A;  3PFV A;  4L1B B;  1JU5 A;  1LUK A;  2EYZ A;  1BLJ A;  4P9V A;  2Y3A B;  3WA4 A;  1O4J A;  1YVL A;  2Y1M A;  2RSY A;  1JYU A;  4K11 A;  4H34 A;  2EYY A;  2XP1 A;  2YSX A;  1X6C A;  3VS4 A;  5EG3 B;  2CI8 A;  5EHP A;  1AYB A;  3BUM B;  5AUL A;  1XA6 A;  2B3O A;  4OHL A;  3N84 A;  2CRH A;  2IZV A;  3M7F A;  2LNX A;  2ABL A;  1BKL A;  2KGY A;  1M27 A;  1OO3 A;  1OPL A;  1AYD A;  4K2R A;  5KAZ A;  1LKL A;  5GJI A;  1JWO A;  3MXC A;  3T04 A;  3CBL A;  2PTK A;  3VS3 A;  2GE9 A;  4TZI A;  2L4K A;  2LQN A;  1R1P A;  3GXW A;  3IN8 A;  3S8O A;  1G83 A;  4D8K A;  5IBS A;  1M61 A;  4FBN A;  2LQW A;  1CSY A;  1FU5 A;  3VS1 A;  1BHH B;  1O4H A;  4K44 A;  2EO6 A;  3UYO A;  1X27 A;  3IMJ A;  3BUO B;  2AOB A;  3N7Y A;  2ROR A;  2QMS A;  2DCR A;  2IUI A;  3CWG A;  2IUH A;  4U17 A;  1O4E A;  2CBL A;  1BF5 A;  1O4O A;  3VRQ A;  1LUI A;  1BHF A;  3CD3 A;  5IBM A;  2PLD A;  2HDX A;  1O46 A;  1Z3K A;  2LRA A;  1O43 A;  4NWG A;  1CJ1 A;  1O49 A;  1O4B A;  1SHA A;  4XZ0 A;  4JE4 A;  1QAD A;  4NWF A;  1O4A A;  3OB1 B;  4F59 A;  1O4L A;  2MC1 A;  4A4B A;  4WWQ A;  2HCK A;  2K79 B;  4DGX A;  1F1W A;  3OVE A;  2MK2 A;  3S8L A;  2GSB A;  4M4Z A;  3BUW B;  2H5K A;  5DC4 A;  1O4N A;  1MIL A;  3VRO A;  2MQI A;  2EKX A;  3PLF B;  1O4I A;  1LKK A;  3BKB A;  1PIC A;  1CWD L;  4JGH A;  3VRY A;  1LCJ A;  1O4K A;  2HDV A;  4DGP A;  3OV1 A;  2EO3 A;  1F2F A;  1LUM A;  2C0O A;  3EAC A;  4E68 A;  3QWX X;  3OP0 A;  1RPY A;  4QSY A;  1WQU A;  1O4D A;  1QG1 E;  1A07 A;  1O44 A;  4OHE A;  1FHS A;  1IS0 A;  3GXX A;  4XZ1 A;  2AUG A;  2C9W A;  3VRR A;  3VS7 A;  1O4M A;  2EYV A;  2EU0 A;  3C7I A;  3K2T A;  1O4C A;  2DM0 A;  5EEL A;  1A1B A;  1BG1 A;  1QCF A;  1OO4 A;  1AYA A;  1NZL A;  1SHB A;  1AYC A;  1O47 A;  1I3Z A;  1AB2 A;  2PNB A;  1O48 A;  1SPR A;  1O4R A;  2MRK A;  2VIF A;  3VS5 A;  2CR4 A;  1D4W A;  3VRP A;  2ECD A;  2HUW A;  2PNA A;  3QWY A;  4F5A A;  1P13 A;  4GPL B;  4EY0 A;  1BHH A;  1BFJ A;  2H8H A;  1H9O A;  1KSW A;  2RVF A;  2CI9 A;  1BMB A;  2LCT A;  2OZO A;  2RMX A;  2L6K A;  5BO4 A;  1A1C A;  1LCK A;  2PLE A;  3KFJ A;  1BKM A;  2C0I A;  1CWE A;  2DX0 A;  1O4G A;  3HIZ B;  4OHD A;  3MAZ A;  3IMD A;  1AOT F;  1AOU F;  1JYQ A;  2DVJ A;  3VS0 A;  2SRC A;  2LNW A;  1R1S A;  1UUS A;  2L3T A;  4U1P A;  3PJP A;  1MW4 A;  5DC0 B;  1FBV A;  1K9A A;  3PSJ A;  2DLY A;  1AD5 A;  2FO0 A;  1D1Z A;  5DF6 A;  1FMK A;  1A08 A;  4LUD A;  5HKY A;  2K7A B;  5CDW A;  1RJA A;  1LUN A;  2BBU A;  1A81 A;  4ROJ A;  1HCS B;  1KA7 A;  1Y57 A;  2SHP A;  2KNO A;  1A1E A;  1IJR A;  3OB2 B;  4A4C A;  3VS2 A;  3PSK A;  5EEQ A;  3EAZ A;  1O41 A;  1YVH A;  4FL2 A;  1FYR A;  2CS0 A;  3S9K A;  3VRZ A;  1B47 A;  1O42 A;  4LUE A;  2ETZ A;  3HHM B;  4X6S A;  3TL0 A;  5HKW A;  1Y1U A;  1O4Q A;  4H1O A;  3TKZ A;  3VRN A;  3UF4 A;  3BUN B;  3US4 A;  2DLZ A;  3CXL A;  4EIH A;  3S8N A;  1X0N A;  3HCK A;  1FU6 A;  5J3X A;  4JEG A;  1NZV A;  2OQ1 A;  4P9Z A;  1UUR A;  5EHR A;  3VGO A;  3NHN A;  2H46 E;  3BUX B;  4OHH A;  4F5B A;  1GHU A;  5DC9 A;  5GJH A;  2HMH A; 
#chains in the Genus database with same CATH homology
 2Y1N A;  1BFI A;  3MXY A;  1OPK A;  1CSZ A;  1TZE E;  5AXI A;  2AOA A;  1SPS A;  4OHI A;  5HKZ A;  2FCI A;  1O45 A;  1ZFP E;  2IUG A;  1BLK A;  2CIA A;  1KA6 A;  2JYQ A;  1R1Q A;  1SKJ A;  3PS5 A;  4GL9 E;  5D0J A;  4K45 A;  3PQZ A;  1GRI A;  1KC2 A;  1O4P A;  1SHD A;  3IN7 A;  4E93 A;  5I6V A;  1A09 A;  2MRJ A;  1HCT B;  1TCE A;  1RQQ C;  1BM2 A;  3VS6 A;  3K2M A;  1NRV A;  3ZNI A;  2YU7 A;  2KK6 A;  2C0T A;  1FBZ A;  4GWF A;  1D4T A;  1A1A A;  1JYR A;  4FL3 A;  3GQI B;  1O4F A;  3N8M A;  2EOB A;  2EL8 A;  3PFV A;  4L1B B;  1JU5 A;  1LUK A;  2EYZ A;  1BLJ A;  4P9V A;  2Y3A B;  3WA4 A;  1O4J A;  1YVL A;  2Y1M A;  2RSY A;  1JYU A;  4K11 A;  4H34 A;  2EYY A;  2XP1 A;  2YSX A;  1X6C A;  3VS4 A;  5EG3 B;  2CI8 A;  5EHP A;  1AYB A;  3BUM B;  5AUL A;  1XA6 A;  2B3O A;  4OHL A;  3N84 A;  2CRH A;  2IZV A;  3M7F A;  2LNX A;  2ABL A;  1BKL A;  1M27 A;  1OO3 A;  1OPL A;  1AYD A;  4K2R A;  5KAZ A;  1LKL A;  5GJI A;  1JWO A;  3MXC A;  3T04 A;  3CBL A;  2PTK A;  3VS3 A;  2GE9 A;  4TZI A;  2L4K A;  2LQN A;  1R1P A;  3GXW A;  3IN8 A;  3S8O A;  1G83 A;  4D8K A;  5IBS A;  1M61 A;  4FBN A;  2LQW A;  1CSY A;  1FU5 A;  3VS1 A;  1BHH B;  1O4H A;  4K44 A;  2EO6 A;  3UYO A;  1X27 A;  3IMJ A;  3BUO B;  2AOB A;  3N7Y A;  2ROR A;  2QMS A;  2DCR A;  2IUI A;  3CWG A;  2IUH A;  4U17 A;  1O4E A;  2CBL A;  1BF5 A;  1O4O A;  3VRQ A;  1LUI A;  1BHF A;  3CD3 A;  5IBM A;  2PLD A;  2HDX A;  1O46 A;  1Z3K A;  4NWG A;  1O43 A;  1CJ1 A;  1O49 A;  1O4B A;  1SHA A;  4XZ0 A;  4JE4 A;  1QAD A;  4NWF A;  1O4A A;  3OB1 B;  4F59 A;  1O4L A;  2MC1 A;  4A4B A;  4WWQ A;  2HCK A;  2K79 B;  4DGX A;  1F1W A;  3OVE A;  2MK2 A;  3S8L A;  2GSB A;  4M4Z A;  3BUW B;  2H5K A;  5DC4 A;  1O4N A;  1MIL A;  3VRO A;  2MQI A;  2EKX A;  3PLF B;  1O4I A;  1LKK A;  3BKB A;  1PIC A;  1CWD L;  4JGH A;  3VRY A;  1LCJ A;  1O4K A;  2HDV A;  4DGP A;  3OV1 A;  2EO3 A;  1F2F A;  1LUM A;  2C0O A;  3EAC A;  4E68 A;  3QWX X;  3OP0 A;  1RPY A;  4QSY A;  1WQU A;  1O4D A;  1QG1 E;  1A07 A;  1O44 A;  4OHE A;  1FHS A;  1IS0 A;  3GXX A;  4XZ1 A;  2AUG A;  2C9W A;  3VRR A;  3VS7 A;  1O4M A;  2EYV A;  2EU0 A;  3C7I A;  1O4C A;  2DM0 A;  5EEL A;  1A1B A;  1BG1 A;  1QCF A;  1OO4 A;  1AYA A;  1NZL A;  1SHB A;  1AYC A;  1O47 A;  1I3Z A;  1AB2 A;  2PNB A;  1O48 A;  1SPR A;  1O4R A;  2MRK A;  2VIF A;  3VS5 A;  2CR4 A;  1D4W A;  3VRP A;  2ECD A;  2HUW A;  2PNA A;  3QWY A;  4F5A A;  1P13 A;  4GPL B;  4EY0 A;  1BHH A;  1BFJ A;  2H8H A;  1H9O A;  1KSW A;  2RVF A;  2CI9 A;  1BMB A;  2LCT A;  2OZO A;  2RMX A;  2L6K A;  5BO4 A;  1A1C A;  1LCK A;  2PLE A;  3KFJ A;  1BKM A;  2C0I A;  1CWE A;  2DX0 A;  1O4G A;  3HIZ B;  4OHD A;  3MAZ A;  3IMD A;  1AOT F;  1AOU F;  1JYQ A;  2DVJ A;  3VS0 A;  2SRC A;  2LNW A;  1R1S A;  1UUS A;  2L3T A;  4U1P A;  3PJP A;  1MW4 A;  5DC0 B;  1FBV A;  1K9A A;  3PSJ A;  2DLY A;  1AD5 A;  2FO0 A;  1D1Z A;  5DF6 A;  1FMK A;  1A08 A;  4LUD A;  5HKY A;  2K7A B;  5CDW A;  1RJA A;  1LUN A;  2BBU A;  1A81 A;  4ROJ A;  1HCS B;  1KA7 A;  1Y57 A;  2SHP A;  2KNO A;  1A1E A;  1IJR A;  3OB2 B;  4A4C A;  3VS2 A;  3PSK A;  5EEQ A;  3EAZ A;  1O41 A;  1YVH A;  4FL2 A;  1FYR A;  2CS0 A;  3S9K A;  3VRZ A;  1B47 A;  1O42 A;  4LUE A;  2ETZ A;  3HHM B;  4X6S A;  3TL0 A;  5HKW A;  1Y1U A;  1O4Q A;  4H1O A;  3TKZ A;  3VRN A;  3UF4 A;  3BUN B;  3US4 A;  2DLZ A;  3CXL A;  4EIH A;  3S8N A;  1X0N A;  3HCK A;  1FU6 A;  5J3X A;  4JEG A;  1NZV A;  2OQ1 A;  4P9Z A;  1UUR A;  5EHR A;  3VGO A;  3NHN A;  2H46 E;  3BUX B;  4OHH A;  4F5B A;  1GHU A;  5DC9 A;  5GJH A;  2HMH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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