2AE0X

Crystal structure of mlta from escherichia coli reveals a unique lytic transglycosylase fold
Total Genus 95
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
95
sequence length
335
structure length
335
Chain Sequence
SKPTDRGQQYKDGKFTQPFSLVNQPDAVGAPINAGDFAEQINHIRNSSPRLYGNQSNVYNAVQEWLRAGGDTRNMRQFGIDAWQMEGADNYGNVQFTGYYTPVIQARHTRQGEFQYPIYRMPPKRGRLSSRAEIYAGALSDKYILAYSNSLMDNFIMDVQGSGYIDFGDGSPLNFFSYAGKNGHAYRSIGKVLIDRGEVKKEDMSMQAIRHWGETHSEAEVRELLEQNPSFVFFKPQSFAPVKGASAVPLVGRASVASDRSIIPPGTTLLAEVPLLDNNGKFNGQYELRLMVALDVGGAIKGQHFDIYQGIGPEAGHRAGWYNHYGRVWVLKTAP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of MltA from Escherichia coli Reveals a Unique Lytic Transglycosylase Fold
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Membrane-bound lytic murein transglycosylase A
total genus 95
structure length 335
sequence length 335
ec nomenclature ec 4.2.2.n1: Peptidoglycan lytic exotransglycosylase.
pdb deposition date 2005-07-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF03562 MltA MltA specific insert domain
X PF06725 3D 3D domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.40.10 Mainly Beta Beta Barrel Barwin-like endoglucanases RlpA-like domain 2ae0X01
2.40.240.50 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Barwin-like endoglucanases 2ae0X02
4JP7A 2ENGA 3X2IA 3X2JA 3D30A 4ENGA 1N10A 2AE0X 1OA7A 4ZM7A 2PI8A 4FERA 3X2KA 2PICA 4AVRA 1HD5A 5GLYA 3X2PA 1BW3A 2G5DA 2BH0A 3SUJA 3CZBA 3X2OA 4JCWA 4JS7A 3SULA 2KQAA 4FFTA 4JP6A 5GM9A 3X2GA 3X2HA 1OA9A 3X2MA 3SUKA 3M3GA 1L8FA 4L48A 2PNWA 4FG4A 5H4UA 1BW4A 2PJJA 4JJOA 2G6GA 2HCZX 3SUMA 3X2LA 3ENGA 2GAEA 5GLXA 1WC2A 4FG2A 3X2NA
chains in the Genus database with same CATH superfamily
2VPWA 2NVYA 2ENGA 1QDNA 4JP7A 3X2JA 2R92A 1VHKA 1H0HA 1Y1VA 1E32A 2AE0X 3CF5S 1ZJWA 1Y5IA 2JIOA 2BE5D 2PICA 5FTKA 5GLFA 2Y0SA 1HD5A 4CS0A 2VPXA 2JIQA 1BW3A 2G5DA 5GAHW 3IR5A 1DMSA 2E2IA 4CRYG 2YU9A 4JP6A 4WFAS 2E2HA 1EXDA 3ML1A 2PJHB 4KODA 3X2MA 1CZ5A 1L8FA 1PQHA 1WLFA 1Y4ZA 4L48A 3QWZA 1PYQA 5EPPA 1QCSA 1PQEA 2PJJA 4KLNA 2HCZX 1QRTA 3W2VB 2JA5A 1YLEA 3W2WB 1DFUP 3X1LB 1Q16A 1TMOA 3IR6A 3IR7A 1WC2A 1E61A 4QIWA 1UHEA 2YUJA 1SFOA 4IOAS 1WCMA 1G8JA 1GTRA 1GTSA 1G8KA 1E60A 2A6HD 3X2IA 4GA5A 1OA7A 1ZC1A 3H0GA 1PPYA 1R7RA 1NYLA 1S3SA 5DM7S 3X2KA 2PMZA 4FERA 5FTJA 3GTLA 1D6KA 4UY88 1AW8B 1QRSA 2V3VA 5B6CA 1YNND 2BH0A 1FDIA 3X2OA 4KDLA 4JS7A 4AONB 3SULA 5C1BA 2KQAA 5FTLA 1I50A 5GM9A 2WAQA 3GTOA 1VC3B 1Y1WA 1VHYA 4H4KA 1OA9A 2JIRA 2ZJPS 3M3GA 5H4UA 2PNWA 1TWGA 5JVHS 1EUYA 4U67S 4IO9S 4AZDA 4AYBA 5JVGS 5BNZA 1V6ZA 2JIMA 3ENGA 5GLXA 2NAPA 3PLXB 2B63A 2RE8A 4KO8A 2VPYA 4RV0A 1KQFA 1Z85A 1E18A 3GTJA 1CZ4A 4WF9S 2NWAA 4JYZA 5T5MD 3GTMA 3D30A 4ENGA 2C45A 1AA6A 1N10A 1SIWA 1QTQA 4ZM7A 2PI8A 5T5ID 3HU2A 2O5JD 4GA6A 1H5NA 3QC8A 1SMYD 1TWAA 2DMRA 1YNJD 2VPZA 5GLYA 4CRZA 1KQGA 2CX8A 2EGVA 3SUJA 3CZBA 3GTKA 3FKIA 4JCWA 3X2HA 1PT0A 4WFNS 1I3QA 5IZNA 1OGYA 2A69D 5FTMA 3TM7B 2JIPA 1BW4A 1R27A 3HU3A 4KDIA 3SUMA 3QQ8A 2NVXA 2E7ZA 1UDXA 1O0BA 3KW2A 3J7ZV 1NXZA 4JXXA 2V45A 2EEOB 1E5VA 1EU1A 4JXZA 2GAEA 4NOHA 2Z0YA 3AIIA 2R7ZA 2CW0D 2ZJQS 3HKZA 1IW7D 3GTQA 1TWCA 3CF2A 3DLLS 1B75A 3DMRA 3X2NA 2R93A 4AAYA 3TIWA 4J3CA 2EGWA 2KI8A 2A6ED 2IV2X 1DMRA 2VUMA 4AOKB 1O0CA 5DYIA 4C2MA 2NYAA 1TWHA 5GAGW 3PIOS 5GADW 4AVRA 1UHDA 3OUGA 5DYGA 2ZJRS 3X2PA 4P2BA 5FTNA 1FDOA 4E8BA 2A68D 4FFTA 3X2GA 4H3SA 2RD2A 1ZYRD 4IOCS 2WB1A 5GAEW 3GTPA 3SUKA 4FG4A 2JA7A 1R9TA 3HU1A 1PYUB 4JJOA 3PIPS 2G6GA 1K83A 5DM6S 1QRUA 4V194 3CQZA 1FEUA 3QQ7A 3X2LA 5C18A 3O5AA 2JA6A 3GTGA 1TWFA 4WCES 1PT1A 4D7ZB 4DMRA 4FG2A 5HL7S 4WFBS 1EUQA 1PQFA 2HZ7A 4L69A 1CR5A
chains in the Genus database with same CATH topology
2VPWA 4JP7A 2ENGA 3X2JA 1QDNA 2NVYA 2R92A 1H0HA 1Y1VA 1E32A 2AE0X 1Y5IA 2JIOA 2BE5D 2PICA 5FTKA 5GLFA 2Y0SA 1HD5A 4CS0A 2VPXA 2JIQA 1BW3A 2G5DA 3IR5A 1DMSA 2E2IA 4CRYG 2YU9A 4JP6A 2E2HA 3ML1A 2PJHB 3X2MA 4KODA 1CZ5A 1L8FA 4L48A 1PQHA 1WLFA 1Y4ZA 3QWZA 1PYQA 5EPPA 1QCSA 1PQEA 2PJJA 4KLNA 2HCZX 2JA5A 1YLEA 1Q16A 1TMOA 3IR6A 3IR7A 1WC2A 1E61A 4QIWA 1UHEA 2YUJA 1SFOA 1WCMA 1G8JA 1G8KA 1E60A 3X2IA 2A6HD 4GA5A 1OA7A 1ZC1A 3H0GA 1PPYA 1R7RA 1S3SA 3X2KA 4FERA 2PMZA 5FTJA 3GTLA 1AW8B 2V3VA 5B6CA 2BH0A 3X2OA 1FDIA 1YNND 4KDLA 4JS7A 4AONB 3SULA 5C1BA 2KQAA 5FTLA 1I50A 5GM9A 2WAQA 3GTOA 1VC3B 1Y1WA 1OA9A 2JIRA 3M3GA 5H4UA 2PNWA 1TWGA 4AZDA 4AYBA 2JIMA 3ENGA 5GLXA 2NAPA 3PLXB 2B63A 4KO8A 2VPYA 4RV0A 1KQFA 1E18A 3GTJA 1CZ4A 5T5MD 3GTMA 3D30A 4ENGA 2C45A 1AA6A 1N10A 1SIWA 4ZM7A 2PI8A 5T5ID 3HU2A 2O5JD 4GA6A 1H5NA 3QC8A 5GLYA 1SMYD 1TWAA 1YNJD 2DMRA 2VPZA 4CRZA 1KQGA 3SUJA 3CZBA 3GTKA 4JCWA 3FKIA 3X2HA 1PT0A 1I3QA 1OGYA 2A69D 5FTMA 3TM7B 2JIPA 1BW4A 1R27A 3HU3A 4KDIA 3SUMA 3QQ8A 2NVXA 2E7ZA 2V45A 2EEOB 1E5VA 1EU1A 2GAEA 4NOHA 2R7ZA 2CW0D 3HKZA 1IW7D 3GTQA 1TWCA 3CF2A 3DMRA 3X2NA 2R93A 4AAYA 3TIWA 2KI8A 2A6ED 2IV2X 1DMRA 2VUMA 4AOKB 5DYIA 4C2MA 2NYAA 1TWHA 4AVRA 1UHDA 3OUGA 5DYGA 3X2PA 5FTNA 1FDOA 2A68D 4FFTA 3X2GA 1ZYRD 2WB1A 3GTPA 3SUKA 4FG4A 2JA7A 1R9TA 3HU1A 1PYUB 4JJOA 2G6GA 1K83A 3CQZA 3X2LA 3QQ7A 5C18A 3O5AA 2JA6A 3GTGA 1TWFA 1PT1A 4D7ZB 4DMRA 4FG2A 1PQFA 1CR5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4JP7 A;  2ENG A;  3X2I A;  3X2J A;  3D30 A;  4ENG A;  1N10 A;  2AE0 X;  1OA7 A;  4ZM7 A;  2PI8 A;  4FER A;  3X2K A;  2PIC A;  4AVR A;  1HD5 A;  5GLY A;  3X2P A;  1BW3 A;  2G5D A;  2BH0 A;  3SUJ A;  3CZB A;  3X2O A;  4JCW A;  4JS7 A;  3SUL A;  2KQA A;  4FFT A;  4JP6 A;  5GM9 A;  3X2G A;  3X2H A;  1OA9 A;  3X2M A;  3SUK A;  3M3G A;  1L8F A;  4L48 A;  2PNW A;  4FG4 A;  5H4U A;  1BW4 A;  2PJJ A;  4JJO A;  2G6G A;  2HCZ X;  3SUM A;  3X2L A;  3ENG A;  2GAE A;  5GLX A;  1WC2 A;  4FG2 A;  3X2N A; 
#chains in the Genus database with same CATH topology
 2VPW A;  2NVY A;  2ENG A;  1QDN A;  4JP7 A;  3X2J A;  2R92 A;  1VHK A;  1H0H A;  1Y1V A;  1E32 A;  2AE0 X;  3CF5 S;  1ZJW A;  1Y5I A;  2JIO A;  2BE5 D;  2PIC A;  5FTK A;  5GLF A;  2Y0S A;  1HD5 A;  4CS0 A;  2VPX A;  2JIQ A;  1BW3 A;  2G5D A;  5GAH W;  3IR5 A;  1DMS A;  2E2I A;  4CRY G;  2YU9 A;  4JP6 A;  4WFA S;  2E2H A;  1EXD A;  3ML1 A;  2PJH B;  4KOD A;  3X2M A;  1CZ5 A;  1L8F A;  1PQH A;  1WLF A;  1Y4Z A;  4L48 A;  3QWZ A;  1PYQ A;  5EPP A;  1QCS A;  1PQE A;  2PJJ A;  4KLN A;  2HCZ X;  1QRT A;  3W2V B;  2JA5 A;  1YLE A;  3W2W B;  1DFU P;  3X1L B;  1Q16 A;  1TMO A;  3IR6 A;  3IR7 A;  1WC2 A;  1E61 A;  4QIW A;  1UHE A;  2YUJ A;  1SFO A;  4IOA S;  1WCM A;  1G8J A;  1GTR A;  1GTS A;  1G8K A;  1E60 A;  2A6H D;  3X2I A;  4GA5 A;  1OA7 A;  1ZC1 A;  3H0G A;  1PPY A;  1R7R A;  1NYL A;  1S3S A;  5DM7 S;  3X2K A;  2PMZ A;  4FER A;  5FTJ A;  3GTL A;  1D6K A;  4UY8 8;  1AW8 B;  1QRS A;  2V3V A;  5B6C A;  1YNN D;  2BH0 A;  1FDI A;  3X2O A;  4KDL A;  4JS7 A;  4AON B;  3SUL A;  5C1B A;  2KQA A;  5FTL A;  1I50 A;  5GM9 A;  2WAQ A;  3GTO A;  1VC3 B;  1Y1W A;  1VHY A;  4H4K A;  1OA9 A;  2JIR A;  2ZJP S;  3M3G A;  5H4U A;  2PNW A;  1TWG A;  5JVH S;  1EUY A;  4U67 S;  4IO9 S;  4AZD A;  4AYB A;  5JVG S;  5BNZ A;  1V6Z A;  2JIM A;  3ENG A;  5GLX A;  2NAP A;  3PLX B;  2B63 A;  2RE8 A;  4KO8 A;  2VPY A;  4RV0 A;  1KQF A;  1Z85 A;  1E18 A;  3GTJ A;  1CZ4 A;  4WF9 S;  2NWA A;  4JYZ A;  5T5M D;  3GTM A;  3D30 A;  4ENG A;  2C45 A;  1AA6 A;  1N10 A;  1SIW A;  1QTQ A;  4ZM7 A;  2PI8 A;  5T5I D;  3HU2 A;  2O5J D;  4GA6 A;  1H5N A;  3QC8 A;  1SMY D;  1TWA A;  2DMR A;  1YNJ D;  2VPZ A;  5GLY A;  4CRZ A;  1KQG A;  2CX8 A;  2EGV A;  3SUJ A;  3CZB A;  3GTK A;  3FKI A;  4JCW A;  3X2H A;  1PT0 A;  4WFN S;  1I3Q A;  5IZN A;  1OGY A;  2A69 D;  5FTM A;  3TM7 B;  2JIP A;  1BW4 A;  1R27 A;  3HU3 A;  4KDI A;  3SUM A;  3QQ8 A;  2NVX A;  2E7Z A;  1UDX A;  1O0B A;  3KW2 A;  3J7Z V;  1NXZ A;  4JXX A;  2V45 A;  2EEO B;  1E5V A;  1EU1 A;  4JXZ A;  2GAE A;  4NOH A;  2Z0Y A;  3AII A;  2R7Z A;  2CW0 D;  2ZJQ S;  3HKZ A;  1IW7 D;  3GTQ A;  1TWC A;  3CF2 A;  3DLL S;  1B75 A;  3DMR A;  3X2N A;  2R93 A;  4AAY A;  3TIW A;  4J3C A;  2EGW A;  2KI8 A;  2A6E D;  2IV2 X;  1DMR A;  2VUM A;  4AOK B;  1O0C A;  5DYI A;  4C2M A;  2NYA A;  1TWH A;  5GAG W;  3PIO S;  5GAD W;  4AVR A;  1UHD A;  3OUG A;  5DYG A;  2ZJR S;  3X2P A;  4P2B A;  5FTN A;  1FDO A;  4E8B A;  2A68 D;  4FFT A;  3X2G A;  4H3S A;  2RD2 A;  1ZYR D;  4IOC S;  2WB1 A;  5GAE W;  3GTP A;  3SUK A;  4FG4 A;  2JA7 A;  1R9T A;  3HU1 A;  1PYU B;  4JJO A;  3PIP S;  2G6G A;  1K83 A;  5DM6 S;  1QRU A;  4V19 4;  3CQZ A;  1FEU A;  3QQ7 A;  3X2L A;  5C18 A;  3O5A A;  2JA6 A;  3GTG A;  1TWF A;  4WCE S;  1PT1 A;  4D7Z B;  4DMR A;  4FG2 A;  5HL7 S;  4WFB S;  1EUQ A;  1PQF A;  2HZ7 A;  4L69 A;  1CR5 A; 
#chains in the Genus database with same CATH homology
 2VPW A;  4JP7 A;  2ENG A;  3X2J A;  1QDN A;  2NVY A;  2R92 A;  1H0H A;  1Y1V A;  1E32 A;  2AE0 X;  1Y5I A;  2JIO A;  2BE5 D;  2PIC A;  5FTK A;  5GLF A;  2Y0S A;  1HD5 A;  4CS0 A;  2VPX A;  2JIQ A;  1BW3 A;  2G5D A;  3IR5 A;  1DMS A;  2E2I A;  4CRY G;  2YU9 A;  4JP6 A;  2E2H A;  3ML1 A;  2PJH B;  3X2M A;  4KOD A;  1CZ5 A;  1L8F A;  4L48 A;  1PQH A;  1WLF A;  1Y4Z A;  3QWZ A;  1PYQ A;  5EPP A;  1QCS A;  1PQE A;  2PJJ A;  4KLN A;  2HCZ X;  2JA5 A;  1YLE A;  1Q16 A;  1TMO A;  3IR6 A;  3IR7 A;  1WC2 A;  1E61 A;  4QIW A;  1UHE A;  2YUJ A;  1SFO A;  1WCM A;  1G8J A;  1G8K A;  1E60 A;  3X2I A;  2A6H D;  4GA5 A;  1OA7 A;  1ZC1 A;  3H0G A;  1PPY A;  1R7R A;  1S3S A;  3X2K A;  4FER A;  2PMZ A;  5FTJ A;  3GTL A;  1AW8 B;  2V3V A;  5B6C A;  2BH0 A;  3X2O A;  1FDI A;  1YNN D;  4KDL A;  4JS7 A;  4AON B;  3SUL A;  5C1B A;  2KQA A;  5FTL A;  1I50 A;  5GM9 A;  2WAQ A;  3GTO A;  1VC3 B;  1Y1W A;  1OA9 A;  2JIR A;  3M3G A;  5H4U A;  2PNW A;  1TWG A;  4AZD A;  4AYB A;  2JIM A;  3ENG A;  5GLX A;  2NAP A;  3PLX B;  2B63 A;  4KO8 A;  2VPY A;  4RV0 A;  1KQF A;  1E18 A;  3GTJ A;  1CZ4 A;  5T5M D;  3GTM A;  3D30 A;  4ENG A;  2C45 A;  1AA6 A;  1N10 A;  1SIW A;  4ZM7 A;  2PI8 A;  5T5I D;  3HU2 A;  2O5J D;  4GA6 A;  1H5N A;  3QC8 A;  5GLY A;  1SMY D;  1TWA A;  1YNJ D;  2DMR A;  2VPZ A;  4CRZ A;  1KQG A;  3SUJ A;  3CZB A;  3GTK A;  4JCW A;  3FKI A;  3X2H A;  1PT0 A;  1I3Q A;  1OGY A;  2A69 D;  5FTM A;  3TM7 B;  2JIP A;  1BW4 A;  1R27 A;  3HU3 A;  4KDI A;  3SUM A;  3QQ8 A;  2NVX A;  2E7Z A;  2V45 A;  2EEO B;  1E5V A;  1EU1 A;  2GAE A;  4NOH A;  2R7Z A;  2CW0 D;  3HKZ A;  1IW7 D;  3GTQ A;  1TWC A;  3CF2 A;  3DMR A;  3X2N A;  2R93 A;  4AAY A;  3TIW A;  2KI8 A;  2A6E D;  2IV2 X;  1DMR A;  2VUM A;  4AOK B;  5DYI A;  4C2M A;  2NYA A;  1TWH A;  4AVR A;  1UHD A;  3OUG A;  5DYG A;  3X2P A;  5FTN A;  1FDO A;  2A68 D;  4FFT A;  3X2G A;  1ZYR D;  2WB1 A;  3GTP A;  3SUK A;  4FG4 A;  2JA7 A;  1R9T A;  3HU1 A;  1PYU B;  4JJO A;  2G6G A;  1K83 A;  3CQZ A;  3X2L A;  3QQ7 A;  5C18 A;  3O5A A;  2JA6 A;  3GTG A;  1TWF A;  1PT1 A;  4D7Z B;  4DMR A;  4FG2 A;  1PQF A;  1CR5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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