1KQ7 | Genus

Total Genus 162

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	162
sequence length	456
structure length	456
Chain Sequence	VRSEKDSMGAIDVPADKLWGAQTQRSLEHFRISTEKMPTSLIHALALTKRAAAKVNEDLGLLSEEKASAIRQAADEVLAGQHDDEFPLAIWQTGSGTQSNMNMNEVLANRASELLGGVRGMERKVHPNDDVNKSQSSNDVFPTAMHVAALLALRKQLIPQLKTLTQTLNEKSRAFADIVKIGRTHLQDATPLTLGQEISGWVAMLEHNLKHIEYSLPHVAELALGGTAVGTGLNTHPEYARRVADELAVITCAPFVTAPNKFEALATCDALVQAHGALKGLAASLMKIANDVRWLASGPRCGIGEISIPENQPGSSIMPGKVNPTQCEALTMLCCQVMGNDVAINMGGASGNFELNVFRPMVIHNFLQSVRLLADGMESFNKHCAVGIEPNRERINQLLNESLMLVTALNTHIGYDKAAEIAKKAHKEGLTLKAAALALGYLSEAEFDSWVRPEQM

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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The Resolver thinks Pdb

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reading 456 atoms

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456 atoms created

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Lyase
source organism	Escherichia coli
publication title	X-ray crystallographic and kinetic correlation of a clinically observed human fumarase mutation. pubmed doi rcsb
molecule keywords	FUMARATE HYDRATASE CLASS II
total genus	162
structure length	456
sequence length	456
chains with identical sequence	B
ec nomenclature	ec 4.2.1.2: Fumarate hydratase.
pdb deposition date	2002-01-04

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00206	Lyase_1	Lyase
A	PF10415	FumaraseC_C	Fumarase C C-terminus

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.40.30	Mainly Alpha	Orthogonal Bundle	Ribonucleotide Reductase Protein R1; domain 1	Fumarase/aspartase (C-terminal domain)	1kq7A03
1.10.275.10	Mainly Alpha	Orthogonal Bundle	Fumarase C; Chain B, domain 1	Fumarase/aspartase (N-terminal domain)	1kq7A01
1.20.200.10	Mainly Alpha	Up-down Bundle	Fumarase C; Chain A, domain 2	Fumarase/aspartase (Central domain)	1kq7A02

1HY0A 3TV2A 4NLEA 5F92A 1FUPA 1Q5NA 1GK3A 4NSLA 1U15A 1C3UA 1GKJA 1I0AA 1TJVA 2O7FA 1GKMA 2RJSA 4C5RA 1VDKA 4APAA 1TJ7A 3RRPA 5EYVA 1DOFA 4C5UA 4APBA 1DCNA 4EEIA 2O7EA 1C3CA 3RD8A 3GZHA 1XWOA 1T6PA 4ADLA 4C6GA 1KQ7A 1W27A 1K62A 2HVGA 2O6YA 4FLCA 1FUQA 1FUOA 4FFXA 2X75A 1K7WA 3QBPA 2RJRA 2PTQA 4C5SA 5F91A 5EYTA 3OCFA 1YISA 4HGVA 1EB4A 3GTDA 3NZ4A 3BHGA 2PTSA 3R6YA 3C8TA 2QGAB 3R6VA 1JSWA 1TJWA 2PFMA 2J91A 2NYNA 2O78A 1J3UA 3CZOA 1AUWA 3OCEA 2OHYA 1U16A 3UNVA 4BABA 2O7DA 4EFCA 1FURA 2PTRA 4MX2A 1T6JA 5HW2A 4BAAA 1B8FA 4ADMA 1YFMA 2NYFA 2FUSA 5D6BA 4V2RA 1RE5A 3KDYA 3KDZA 3R6QA 4CQ5A 4V2QA 1HY1A 1YFEA 1GK2A 2VD6A 3NO9A 3E04A 2YIIA 2QVEA 1TJUA 2O7BA 1Y2MA 2E9FA
chains in the Genus database with same CATH superfamily

1HY0A 3U13A 3TV2A 1IW7D 4NLEA 2I7DA 3CI0K 5F92A 4L57A 4L6CA 1FUPA 1Q5NA 1GK3A 4NSLA 1U15A 1U0LA 2FENA 1C3UA 1GKJA 1I0AA 1TJVA 1Z4MA 2O7FA 2JAWA 3F4TA 4YIHA 1GKMA 2RJSA 4C5RA 2RCNA 1VDKA 4APAA 3F4SA 1XL7A 1TJ7A 1XL8A 3RRPA 2VSFA 3F4RA 5EYVA 1DOFA 4C5UA 4APBA 5M0JA 1DCNA 4EEIA 1XLYA 4NFLA 2O7EA 1C3CA 3RD8A 3GZHA 1XWOA 1T6PA 1T9HA 2JAOA 4ADLA 4C6GA 1Z4PX 1KQ7A 1W27A 1Z4JA 1K62A 2JAUA 2HVGA 2O6YA 4FLCA 2FELA 1FUQA 2JARA 1FUOA 4YIKA 4FFXA 2X75A 4A15A 1K7WA 3QBPA 2RJRA 2PTQA 4C5SA 4MUMA 5F91A 5EYTA 5M0IA 3OCFA 1YISA 4HGVA 1EB4A 3BWVA 3GTDA 3NZ4A 3BHGA 2PTSA 3CRVA 3R6YA 3C8TA 2QGAB 3R6VA 5H8WA 1JSWA 1TJWA 2PFMA 2J91A 2NYNA 2O78A 1Z4KA 1J3UA 3CZOA 3CRW1 1AUWA 3OCEA 4IQJM 2OHYA 1U16A 3UNVA 1XMCA 4BABA 1Q92A 2O7DA 2VL7A 4EFCA 1FURA 1Z4QA 2PTRA 2D28C 4MX2A 1T6JA 4WNLA 5HW2A 4BAAA 1B8FA 4ADMA 3U19A 4E88A 1YFMA 2NYFA 2FUSA 4L6AA 5D6BA 4V2RA 1RE5A 3KDYA 2D27A 3KDZA 1MH9A 3R6QA 4MWOA 1XMDA 2YV5A 4CQ5A 4V2QA 1HY1A 1Z4IA 1YFEA 1GK2A 2VD6A 3NO9A 3E04A 2YIIA 2QVEA 1TJUA 2O7BA 1Z4LA 1Y2MA 2E9FA 1Q91A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 1HY0 A;  3TV2 A;  4NLE A;  5F92 A;  1FUP A;  1Q5N A;  1GK3 A;  4NSL A;  1U15 A;  1C3U A;  1GKJ A;  1I0A A;  1TJV A;  2O7F A;  1GKM A;  2RJS A;  4C5R A;  1VDK A;  4APA A;  1TJ7 A;  3RRP A;  5EYV A;  1DOF A;  4C5U A;  4APB A;  1DCN A;  4EEI A;  2O7E A;  1C3C A;  3RD8 A;  3GZH A;  1XWO A;  1T6P A;  4ADL A;  4C6G A;  1KQ7 A;  1W27 A;  1K62 A;  2HVG A;  2O6Y A;  4FLC A;  1FUQ A;  1FUO A;  4FFX A;  2X75 A;  1K7W A;  3QBP A;  2RJR A;  2PTQ A;  4C5S A;  5F91 A;  5EYT A;  3OCF A;  1YIS A;  4HGV A;  1EB4 A;  3GTD A;  3NZ4 A;  3BHG A;  2PTS A;  3R6Y A;  3C8T A;  2QGA B;  3R6V A;  1JSW A;  1TJW A;  2PFM A;  2J91 A;  2NYN A;  2O78 A;  1J3U A;  3CZO A;  1AUW A;  3OCE A;  2OHY A;  1U16 A;  3UNV A;  4BAB A;  2O7D A;  4EFC A;  1FUR A;  2PTR A;  4MX2 A;  1T6J A;  5HW2 A;  4BAA A;  1B8F A;  4ADM A;  1YFM A;  2NYF A;  2FUS A;  5D6B A;  4V2R A;  1RE5 A;  3KDY A;  3KDZ A;  3R6Q A;  4CQ5 A;  4V2Q A;  1HY1 A;  1YFE A;  1GK2 A;  2VD6 A;  3NO9 A;  3E04 A;  2YII A;  2QVE A;  1TJU A;  2O7B A;  1Y2M A;  2E9F A; 
#chains in the Genus database with same CATH topology
 1HY0 A;  3U13 A;  3TV2 A;  1IW7 D;  4NLE A;  2I7D A;  3CI0 K;  5F92 A;  4L57 A;  4L6C A;  1FUP A;  1Q5N A;  1GK3 A;  4NSL A;  1U15 A;  1U0L A;  2FEN A;  1C3U A;  1GKJ A;  1I0A A;  1TJV A;  1Z4M A;  2O7F A;  2JAW A;  3F4T A;  4YIH A;  1GKM A;  2RJS A;  4C5R A;  2RCN A;  1VDK A;  4APA A;  3F4S A;  1XL7 A;  1TJ7 A;  1XL8 A;  3RRP A;  2VSF A;  3F4R A;  5EYV A;  1DOF A;  4C5U A;  4APB A;  5M0J A;  1DCN A;  4EEI A;  1XLY A;  4NFL A;  2O7E A;  1C3C A;  3RD8 A;  3GZH A;  1XWO A;  1T6P A;  1T9H A;  2JAO A;  4ADL A;  4C6G A;  1Z4P X;  1KQ7 A;  1W27 A;  1Z4J A;  1K62 A;  2JAU A;  2HVG A;  2O6Y A;  4FLC A;  2FEL A;  1FUQ A;  2JAR A;  1FUO A;  4YIK A;  4FFX A;  2X75 A;  4A15 A;  1K7W A;  3QBP A;  2RJR A;  2PTQ A;  4C5S A;  4MUM A;  5F91 A;  5EYT A;  5M0I A;  3OCF A;  1YIS A;  4HGV A;  1EB4 A;  3BWV A;  3GTD A;  3NZ4 A;  3BHG A;  2PTS A;  3CRV A;  3R6Y A;  3C8T A;  2QGA B;  3R6V A;  5H8W A;  1JSW A;  1TJW A;  2PFM A;  2J91 A;  2NYN A;  2O78 A;  1Z4K A;  1J3U A;  3CZO A;  3CRW 1;  1AUW A;  3OCE A;  4IQJ M;  2OHY A;  1U16 A;  3UNV A;  1XMC A;  4BAB A;  1Q92 A;  2O7D A;  2VL7 A;  4EFC A;  1FUR A;  1Z4Q A;  2PTR A;  2D28 C;  4MX2 A;  1T6J A;  4WNL A;  5HW2 A;  4BAA A;  1B8F A;  4ADM A;  3U19 A;  4E88 A;  1YFM A;  2NYF A;  2FUS A;  4L6A A;  5D6B A;  4V2R A;  1RE5 A;  3KDY A;  2D27 A;  3KDZ A;  1MH9 A;  3R6Q A;  4MWO A;  1XMD A;  2YV5 A;  4CQ5 A;  4V2Q A;  1HY1 A;  1Z4I A;  1YFE A;  1GK2 A;  2VD6 A;  3NO9 A;  3E04 A;  2YII A;  2QVE A;  1TJU A;  2O7B A;  1Z4L A;  1Y2M A;  2E9F A;  1Q91 A; 
#chains in the Genus database with same CATH homology
 1HY0 A;  3TV2 A;  4NLE A;  5F92 A;  1FUP A;  1Q5N A;  1GK3 A;  4NSL A;  1U15 A;  1C3U A;  1GKJ A;  1I0A A;  1TJV A;  2O7F A;  1GKM A;  2RJS A;  4C5R A;  1VDK A;  4APA A;  1TJ7 A;  3RRP A;  5EYV A;  1DOF A;  4C5U A;  4APB A;  1DCN A;  4EEI A;  2O7E A;  1C3C A;  3RD8 A;  3GZH A;  1XWO A;  1T6P A;  4ADL A;  4C6G A;  1KQ7 A;  1W27 A;  1K62 A;  2HVG A;  2O6Y A;  4FLC A;  1FUQ A;  1FUO A;  4FFX A;  2X75 A;  1K7W A;  3QBP A;  2RJR A;  2PTQ A;  4C5S A;  5F91 A;  5EYT A;  3OCF A;  1YIS A;  4HGV A;  1EB4 A;  3GTD A;  3NZ4 A;  3BHG A;  2PTS A;  3R6Y A;  3C8T A;  2QGA B;  3R6V A;  1JSW A;  1TJW A;  2PFM A;  2J91 A;  2NYN A;  2O78 A;  1J3U A;  3CZO A;  1AUW A;  3OCE A;  2OHY A;  1U16 A;  3UNV A;  4BAB A;  2O7D A;  4EFC A;  1FUR A;  2PTR A;  4MX2 A;  1T6J A;  5HW2 A;  4BAA A;  1B8F A;  4ADM A;  1YFM A;  2NYF A;  2FUS A;  5D6B A;  4V2R A;  1RE5 A;  3KDY A;  3KDZ A;  3R6Q A;  4CQ5 A;  4V2Q A;  1HY1 A;  1YFE A;  1GK2 A;  2VD6 A;  3NO9 A;  3E04 A;  2YII A;  2QVE A;  1TJU A;  2O7B A;  1Y2M A;  2E9F A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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1KQ7A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations