3CF5S

Thiopeptide antibiotic thiostrepton bound to the large ribosomal subunit of deinococcus radiodurans
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
175
structure length
175
Chain Sequence
MELTAKPRTPKQKLDESMIAAVAYNKENNVSFALDRKAFDRAFRQQSTTGLFDITVEGGETFPALVKAVQMDKRKRAPIHVDFYMVTYGEPVEVSVPVHTTGRSQGEVQGGLVDIVVHNLQIVAPGPRRIPQELVVDVTKMNIGDHITAGDIKLPEGCTLAADPELTVVSVLPPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Translational Regulation Via L11: Molecular Switches on the Ribosome Turned on and Off by Thiostrepton and Micrococcin.
pubmed doi rcsb
molecule tags Ribosome/antibiotic
molecule keywords 50S RIBOSOMAL PROTEIN L33
total genus 18
structure length 175
sequence length 175
ec nomenclature
pdb deposition date 2008-03-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 3cf5S01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 3cf5S02
2RD2A 4JYZA 1QRSA 1O0BA 1QRUA 2RE8A 1O0CA 1EXDA 1FEUA 2HZ7A 5JVGS 4H3SA 4IOAS 4P2BA 5DM6S 3PIPS 4U67S 2ZJQS 1GTSA 3J7ZV 4UY88 1EUYA 2ZJRS 5JVHS 4IO9S 1GTRA 4WFNS 5HL7S 4WF9S 1QTQA 4WCES 2ZJPS 1ZJWA 5GAEW 1NYLA 1B75A 3PIOS 4WFBS 3AIIA 5BNZA 1EUQA 5GAHW 3DLLS 4JXXA 5DM7S 3CF5S 1QRTA 5IZNA 1D6KA 5GAGW 4JXZA 1DFUP 4WFAS 4IOCS 5GADW
chains in the Genus database with same CATH superfamily
2NVTC 2L5NA 4YFXA 4LK0A 1NXZA 2Y0SD 4A3MC 1O0CA 4OIQA 3KW2A 3GTOC 5HQHA 3GTPC 2HZ7A 5JVGS 4A3DC 4V194 4G7HA 2GAEA 2JA6C 1V6ZA 3CZBA 2ZJRS 4BBRC 3S1MC 2L3UA 5IYBC 5IP9C 4GZYA 4WCES 4C3JC 1Y1WC 2A6EA 2O5JA 2A69A 4XLNA 5IYDC 3M4OC 1TWAC 3S2HC 5BNZA 3W2VB 5GAHW 4NOIA 1TWHC 5C4XC 4BY1C 4KMUA 4X6AC 4KN7A 5IZNA 4H4KA 3GTMC 1IW7A 5GADW 2RD2A 5IP7C 1BDFA 2WAQD 5C4JC 4G7ZA 4OINA 3RZOC 3S15C 2WB1D 5D4DA 2E2HC 1EXDA 3S1QC 2PMZD 3HOXC 3M3YC 2E2IC 4Y7NC 1UDXA 3PIPS 3S1RC 2BE5A 1ZYRA 1EUYA 3GTJC 4IO9S 5HL7S 2EGWA 2Z0YA 2NVYC 1QTQA 2KXYA 3EQLA 3FKIC 5GAEW 1YNJA 3HKZD 3K7AC 2B63C 1NYLA 1B75A 3AIIA 4WFBS 3H0GC 2NVXC 3H3VD 4BXXC 2PA8D 3I4MC 1K83C 3DLLS 3GTLC 5DM7S 4LK1A 4JXZA 5GAGW 3HOWC 3PO2C 4WFAS 3S2DC 4QJVA 4XSXA 3RZDC 3S14C 1TWGC 2R7ZC 2KQ1A 1QRSA 2G6GA 5IYCC 3S17C 1QRUA 2RE8A 2CW0A 3GTGC 2R92C 4L69A 1R9TC 2R93C 1YNNA 4MEYA 4IOAS 4OIRA 3X1LB 4C3IC 4JK1A 4YG2A 1I3QC 2PI8A 2NWAA 3J7ZV 2AE0X 2EGVA 1TWCC 1Y1VC 3GTQC 1I6HC 1GTRA 4Y52C 4WFNS 2A68A 2JA8C 4BY7C 2JA7C 4A3LC 1Z85A 1ZJWA 4A3FC 3DXJA 4Q4ZA 5C3EC 2NVQC 2E2JC 4YFKA 4BBSC 4A3JC 3S1NC 1EUQA 1HQMA 5C44C 1SFOC 5FLMC 4MQ9A 1QRTA 2PNWA 1D6KA 3WODA 4G7OA 3CQZC 4XSZA 4XLPA 4J3CA 2PPBA 3HOUC 4AYBD 4JYZA 4MEXA 1O0BA 1SMYA 3I4NC 3S16C 1TWFC 4OIOA 3HOVC 1VHYA 1WCMC 4H3SA 3GTKC 4P2BA 5DM6S 1I50C 4U67S 2ZJQS 1GTSA 4LJZA 2PJJA 4YFNA 5TMFA 3PO3C 4UY88 5TMCA 4A3GC 5JVHS 3W2WB 3LYWA 1VHKA 4LLGA 4WF9S 4OIPA 4A3KC 2VUMC 2ZJPS 2YU9C 4QIWD 2KPUA 4ZH4A 4C3HC 1I6VA 3PIOS 4E8BA 4A3BC 4A3CC 3HOYC 2PICA 4JXXA 4C2MC 3HOZC 4Q5SA 3CF5S 4KN4A 2CX8A 4A3EC 4A3IC 2JA5C 4A93C 1DFUP 1FEUA 2G5DA 4IOCS 2A6HA 2O5IA
chains in the Genus database with same CATH topology
2RD2A 4JYZA 1QRSA 1O0BA 1QRUA 2RE8A 1O0CA 1EXDA 1FEUA 2HZ7A 5JVGS 4H3SA 1UDXA 4IOAS 4V194 4P2BA 5DM6S 3PIPS 4U67S 2ZJQS 1GTSA 3X1LB 3J7ZV 4UY88 1EUYA 2ZJRS 3W2WB 5JVHS 4IO9S 1GTRA 4WFNS 5HL7S 4WF9S 1QTQA 4WCES 2ZJPS 1ZJWA 5GAEW 1NYLA 1B75A 3PIOS 3AIIA 4WFBS 5BNZA 3W2VB 1EUQA 5GAHW 3DLLS 4JXXA 5DM7S 3CF5S 1QRTA 5IZNA 1D6KA 5GAGW 4JXZA 4H4KA 4WFAS 1DFUP 4IOCS 5GADW
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2RD2 A;  4JYZ A;  1QRS A;  1O0B A;  1QRU A;  2RE8 A;  1O0C A;  1EXD A;  1FEU A;  2HZ7 A;  5JVG S;  4H3S A;  4IOA S;  4P2B A;  5DM6 S;  3PIP S;  4U67 S;  2ZJQ S;  1GTS A;  3J7Z V;  4UY8 8;  1EUY A;  2ZJR S;  5JVH S;  4IO9 S;  1GTR A;  4WFN S;  5HL7 S;  4WF9 S;  1QTQ A;  4WCE S;  2ZJP S;  1ZJW A;  5GAE W;  1NYL A;  1B75 A;  3PIO S;  4WFB S;  3AII A;  5BNZ A;  1EUQ A;  5GAH W;  3DLL S;  4JXX A;  5DM7 S;  3CF5 S;  1QRT A;  5IZN A;  1D6K A;  5GAG W;  4JXZ A;  1DFU P;  4WFA S;  4IOC S;  5GAD W; 
#chains in the Genus database with same CATH topology
 2NVT C;  2L5N A;  4YFX A;  4LK0 A;  1NXZ A;  2Y0S D;  4A3M C;  1O0C A;  4OIQ A;  3KW2 A;  3GTO C;  5HQH A;  3GTP C;  2HZ7 A;  5JVG S;  4A3D C;  4V19 4;  4G7H A;  2GAE A;  2JA6 C;  1V6Z A;  3CZB A;  2ZJR S;  4BBR C;  3S1M C;  2L3U A;  5IYB C;  5IP9 C;  4GZY A;  4WCE S;  4C3J C;  1Y1W C;  2A6E A;  2O5J A;  2A69 A;  4XLN A;  5IYD C;  3M4O C;  1TWA C;  3S2H C;  5BNZ A;  3W2V B;  5GAH W;  4NOI A;  1TWH C;  5C4X C;  4BY1 C;  4KMU A;  4X6A C;  4KN7 A;  5IZN A;  4H4K A;  3GTM C;  1IW7 A;  5GAD W;  2RD2 A;  5IP7 C;  1BDF A;  2WAQ D;  5C4J C;  4G7Z A;  4OIN A;  3RZO C;  3S15 C;  2WB1 D;  5D4D A;  2E2H C;  1EXD A;  3S1Q C;  2PMZ D;  3HOX C;  3M3Y C;  2E2I C;  4Y7N C;  1UDX A;  3PIP S;  3S1R C;  2BE5 A;  1ZYR A;  1EUY A;  3GTJ C;  4IO9 S;  5HL7 S;  2EGW A;  2Z0Y A;  2NVY C;  1QTQ A;  2KXY A;  3EQL A;  3FKI C;  5GAE W;  1YNJ A;  3HKZ D;  3K7A C;  2B63 C;  1NYL A;  1B75 A;  3AII A;  4WFB S;  3H0G C;  2NVX C;  3H3V D;  4BXX C;  2PA8 D;  3I4M C;  1K83 C;  3DLL S;  3GTL C;  5DM7 S;  4LK1 A;  4JXZ A;  5GAG W;  3HOW C;  3PO2 C;  4WFA S;  3S2D C;  4QJV A;  4XSX A;  3RZD C;  3S14 C;  1TWG C;  2R7Z C;  2KQ1 A;  1QRS A;  2G6G A;  5IYC C;  3S17 C;  1QRU A;  2RE8 A;  2CW0 A;  3GTG C;  2R92 C;  4L69 A;  1R9T C;  2R93 C;  1YNN A;  4MEY A;  4IOA S;  4OIR A;  3X1L B;  4C3I C;  4JK1 A;  4YG2 A;  1I3Q C;  2PI8 A;  2NWA A;  3J7Z V;  2AE0 X;  2EGV A;  1TWC C;  1Y1V C;  3GTQ C;  1I6H C;  1GTR A;  4Y52 C;  4WFN S;  2A68 A;  2JA8 C;  4BY7 C;  2JA7 C;  4A3L C;  1Z85 A;  1ZJW A;  4A3F C;  3DXJ A;  4Q4Z A;  5C3E C;  2NVQ C;  2E2J C;  4YFK A;  4BBS C;  4A3J C;  3S1N C;  1EUQ A;  1HQM A;  5C44 C;  1SFO C;  5FLM C;  4MQ9 A;  1QRT A;  2PNW A;  1D6K A;  3WOD A;  4G7O A;  3CQZ C;  4XSZ A;  4XLP A;  4J3C A;  2PPB A;  3HOU C;  4AYB D;  4JYZ A;  4MEX A;  1O0B A;  1SMY A;  3I4N C;  3S16 C;  1TWF C;  4OIO A;  3HOV C;  1VHY A;  1WCM C;  4H3S A;  3GTK C;  4P2B A;  5DM6 S;  1I50 C;  4U67 S;  2ZJQ S;  1GTS A;  4LJZ A;  2PJJ A;  4YFN A;  5TMF A;  3PO3 C;  4UY8 8;  5TMC A;  4A3G C;  5JVH S;  3W2W B;  3LYW A;  1VHK A;  4LLG A;  4WF9 S;  4OIP A;  4A3K C;  2VUM C;  2ZJP S;  2YU9 C;  4QIW D;  2KPU A;  4ZH4 A;  4C3H C;  1I6V A;  3PIO S;  4E8B A;  4A3B C;  4A3C C;  3HOY C;  2PIC A;  4JXX A;  4C2M C;  3HOZ C;  4Q5S A;  3CF5 S;  4KN4 A;  2CX8 A;  4A3E C;  4A3I C;  2JA5 C;  4A93 C;  1DFU P;  1FEU A;  2G5D A;  4IOC S;  2A6H A;  2O5I A; 
#chains in the Genus database with same CATH homology
 2RD2 A;  4JYZ A;  1QRS A;  1O0B A;  1QRU A;  2RE8 A;  1O0C A;  1EXD A;  1FEU A;  2HZ7 A;  5JVG S;  4H3S A;  1UDX A;  4IOA S;  4V19 4;  4P2B A;  5DM6 S;  3PIP S;  4U67 S;  2ZJQ S;  1GTS A;  3X1L B;  3J7Z V;  4UY8 8;  1EUY A;  2ZJR S;  3W2W B;  5JVH S;  4IO9 S;  1GTR A;  4WFN S;  5HL7 S;  4WF9 S;  1QTQ A;  4WCE S;  2ZJP S;  1ZJW A;  5GAE W;  1NYL A;  1B75 A;  3PIO S;  3AII A;  4WFB S;  5BNZ A;  3W2V B;  1EUQ A;  5GAH W;  3DLL S;  4JXX A;  5DM7 S;  3CF5 S;  1QRT A;  5IZN A;  1D6K A;  5GAG W;  4JXZ A;  4H4K A;  4WFA S;  1DFU P;  4IOC S;  5GAD W; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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