3E04 | Genus

Total Genus 175

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	175
sequence length	461
structure length	456
Chain Sequence	SFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAIMKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGP

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Lyase
source organism	Homo sapiens
publication title	Crystal structure of human fumarate hydratase rcsb
molecule keywords	Fumarate hydratase
total genus	175
structure length	456
sequence length	461
chains with identical sequence	B, C, D
ec nomenclature	ec 4.2.1.2: Fumarate hydratase.
pdb deposition date	2008-07-30

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00206	Lyase_1	Lyase
A	PF10415	FumaraseC_C	Fumarase C C-terminus

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.40.30	Mainly Alpha	Orthogonal Bundle	Ribonucleotide Reductase Protein R1; domain 1	Fumarase/aspartase (C-terminal domain)	3e04A03
1.10.275.10	Mainly Alpha	Orthogonal Bundle	Fumarase C; Chain B, domain 1	Fumarase/aspartase (N-terminal domain)	3e04A01
1.20.200.10	Mainly Alpha	Up-down Bundle	Fumarase C; Chain A, domain 2	Fumarase/aspartase (Central domain)	3e04A02

4ADMA 1U15A 1TJWA 1C3UA 4BABA 4APAA 1GK2A 4CQ5A 1TJ7A 1FUOA 4C5UA 2E9FA 5HW2A 2PTRA 4C6GA 3QBPA 1J3UA 3R6YA 2O78A 1YFMA 2O7DA 2OHYA 2HVGA 4MX2A 4NLEA 1Q5NA 1I0AA 1Y2MA 1FURA 3OCEA 1W27A 2RJRA 4C5SA 3BHGA 3TV2A 1FUPA 3GTDA 1YISA 4C5RA 5EYVA 2O7FA 3NZ4A 3UNVA 2O7EA 1JSWA 1HY0A 3R6VA 4FLCA 4FFXA 2J91A 2FUSA 2QVEA 3OCFA 2RJSA 1T6PA 1TJUA 3KDYA 1C3CA 4EEIA 2O7BA 1DOFA 1GKJA 5F92A 4V2QA 1RE5A 2PTSA 2PFMA 1DCNA 1YFEA 2X75A 2PTQA 1EB4A 1AUWA 3GZHA 4HGVA 1U16A 3CZOA 1GK3A 1K7WA 3R6QA 1T6JA 1K62A 3NO9A 4NSLA 2NYFA 5D6BA 3E04A 1XWOA 3C8TA 1FUQA 5F91A 4EFCA 3RRPA 4BAAA 1KQ7A 1GKMA 3KDZA 4APBA 2O6YA 1TJVA 2YIIA 5EYTA 4V2RA 1VDKA 3RD8A 2VD6A 1B8FA 2QGAB 4ADLA 2NYNA 1HY1A
chains in the Genus database with same CATH superfamily

4ADMA 2JARA 4MWOA 1U15A 1TJWA 1C3UA 4IQJM 5H8WA 4BABA 2VL7A 4APAA 1GK2A 4CQ5A 1TJ7A 1FUOA 4C5UA 2E9FA 5HW2A 2PTRA 1XMCA 2VSFA 4E88A 4C6GA 3QBPA 1J3UA 3R6YA 2O78A 4L6AA 1YFMA 4NFLA 2O7DA 2FELA 4YIHA 2OHYA 2HVGA 4MX2A 4NLEA 1Q5NA 1I0AA 4A15A 1Y2MA 1XL7A 3CI0K 3F4TA 1FURA 1XL8A 3OCEA 1XMDA 1W27A 2RJRA 4C5SA 3F4SA 1MH9A 2YV5A 3BHGA 3TV2A 1Z4QA 1FUPA 3GTDA 1YISA 4C5RA 2I7DA 4WNLA 3BWVA 1Z4IA 5EYVA 2FENA 2O7FA 3NZ4A 3UNVA 2O7EA 1XLYA 1JSWA 1HY0A 3R6VA 4FLCA 4FFXA 2J91A 1Z4JA 2FUSA 1IW7D 2QVEA 3OCFA 2RJSA 1T6PA 1TJUA 1Z4PX 3KDYA 2JAWA 1Q91A 1C3CA 1T9HA 4EEIA 2O7BA 1DOFA 1GKJA 5F92A 4V2QA 1RE5A 2PTSA 2PFMA 1DCNA 1YFEA 2X75A 3CRW1 2PTQA 3CRVA 1EB4A 1AUWA 1U0LA 4L6CA 3GZHA 2JAOA 4HGVA 2JAUA 1U16A 4MUMA 3CZOA 1K7WA 1GK3A 3R6QA 1T6JA 1K62A 3NO9A 4NSLA 2NYFA 2D27A 5D6BA 3E04A 4L57A 1Z4LA 1Z4KA 3U13A 1Q92A 1XWOA 3C8TA 1FUQA 5F91A 2D28C 5M0JA 4EFCA 2RCNA 3RRPA 4BAAA 1KQ7A 1GKMA 1Z4MA 3KDZA 4YIKA 4APBA 3U19A 5M0IA 2O6YA 1TJVA 3F4RA 2YIIA 4V2RA 5EYTA 1VDKA 3RD8A 2VD6A 1B8FA 2QGAB 4ADLA 2NYNA 1HY1A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4ADM A;  1U15 A;  1TJW A;  1C3U A;  4BAB A;  4APA A;  1GK2 A;  4CQ5 A;  1TJ7 A;  1FUO A;  4C5U A;  2E9F A;  5HW2 A;  2PTR A;  4C6G A;  3QBP A;  1J3U A;  3R6Y A;  2O78 A;  1YFM A;  2O7D A;  2OHY A;  2HVG A;  4MX2 A;  4NLE A;  1Q5N A;  1I0A A;  1Y2M A;  1FUR A;  3OCE A;  1W27 A;  2RJR A;  4C5S A;  3BHG A;  3TV2 A;  1FUP A;  3GTD A;  1YIS A;  4C5R A;  5EYV A;  2O7F A;  3NZ4 A;  3UNV A;  2O7E A;  1JSW A;  1HY0 A;  3R6V A;  4FLC A;  4FFX A;  2J91 A;  2FUS A;  2QVE A;  3OCF A;  2RJS A;  1T6P A;  1TJU A;  3KDY A;  1C3C A;  4EEI A;  2O7B A;  1DOF A;  1GKJ A;  5F92 A;  4V2Q A;  1RE5 A;  2PTS A;  2PFM A;  1DCN A;  1YFE A;  2X75 A;  2PTQ A;  1EB4 A;  1AUW A;  3GZH A;  4HGV A;  1U16 A;  3CZO A;  1GK3 A;  1K7W A;  3R6Q A;  1T6J A;  1K62 A;  3NO9 A;  4NSL A;  2NYF A;  5D6B A;  3E04 A;  1XWO A;  3C8T A;  1FUQ A;  5F91 A;  4EFC A;  3RRP A;  4BAA A;  1KQ7 A;  1GKM A;  3KDZ A;  4APB A;  2O6Y A;  1TJV A;  2YII A;  5EYT A;  4V2R A;  1VDK A;  3RD8 A;  2VD6 A;  1B8F A;  2QGA B;  4ADL A;  2NYN A;  1HY1 A; 
#chains in the Genus database with same CATH topology
 4ADM A;  2JAR A;  4MWO A;  1U15 A;  1TJW A;  1C3U A;  4IQJ M;  5H8W A;  4BAB A;  2VL7 A;  4APA A;  1GK2 A;  4CQ5 A;  1TJ7 A;  1FUO A;  4C5U A;  2E9F A;  5HW2 A;  2PTR A;  1XMC A;  2VSF A;  4E88 A;  4C6G A;  3QBP A;  1J3U A;  3R6Y A;  2O78 A;  4L6A A;  1YFM A;  4NFL A;  2O7D A;  2FEL A;  4YIH A;  2OHY A;  2HVG A;  4MX2 A;  4NLE A;  1Q5N A;  1I0A A;  4A15 A;  1Y2M A;  1XL7 A;  3CI0 K;  3F4T A;  1FUR A;  1XL8 A;  3OCE A;  1XMD A;  1W27 A;  2RJR A;  4C5S A;  3F4S A;  1MH9 A;  2YV5 A;  3BHG A;  3TV2 A;  1Z4Q A;  1FUP A;  3GTD A;  1YIS A;  4C5R A;  2I7D A;  4WNL A;  3BWV A;  1Z4I A;  5EYV A;  2FEN A;  2O7F A;  3NZ4 A;  3UNV A;  2O7E A;  1XLY A;  1JSW A;  1HY0 A;  3R6V A;  4FLC A;  4FFX A;  2J91 A;  1Z4J A;  2FUS A;  1IW7 D;  2QVE A;  3OCF A;  2RJS A;  1T6P A;  1TJU A;  1Z4P X;  3KDY A;  2JAW A;  1Q91 A;  1C3C A;  1T9H A;  4EEI A;  2O7B A;  1DOF A;  1GKJ A;  5F92 A;  4V2Q A;  1RE5 A;  2PTS A;  2PFM A;  1DCN A;  1YFE A;  2X75 A;  3CRW 1;  2PTQ A;  3CRV A;  1EB4 A;  1AUW A;  1U0L A;  4L6C A;  3GZH A;  2JAO A;  4HGV A;  2JAU A;  1U16 A;  4MUM A;  3CZO A;  1K7W A;  1GK3 A;  3R6Q A;  1T6J A;  1K62 A;  3NO9 A;  4NSL A;  2NYF A;  2D27 A;  5D6B A;  3E04 A;  4L57 A;  1Z4L A;  1Z4K A;  3U13 A;  1Q92 A;  1XWO A;  3C8T A;  1FUQ A;  5F91 A;  2D28 C;  5M0J A;  4EFC A;  2RCN A;  3RRP A;  4BAA A;  1KQ7 A;  1GKM A;  1Z4M A;  3KDZ A;  4YIK A;  4APB A;  3U19 A;  5M0I A;  2O6Y A;  1TJV A;  3F4R A;  2YII A;  4V2R A;  5EYT A;  1VDK A;  3RD8 A;  2VD6 A;  1B8F A;  2QGA B;  4ADL A;  2NYN A;  1HY1 A; 
#chains in the Genus database with same CATH homology
 4ADM A;  1U15 A;  1TJW A;  1C3U A;  4BAB A;  4APA A;  1GK2 A;  4CQ5 A;  1TJ7 A;  1FUO A;  4C5U A;  2E9F A;  5HW2 A;  2PTR A;  4C6G A;  3QBP A;  1J3U A;  3R6Y A;  2O78 A;  1YFM A;  2O7D A;  2OHY A;  2HVG A;  4MX2 A;  4NLE A;  1Q5N A;  1I0A A;  1Y2M A;  1FUR A;  3OCE A;  1W27 A;  2RJR A;  4C5S A;  3BHG A;  3TV2 A;  1FUP A;  3GTD A;  1YIS A;  4C5R A;  5EYV A;  2O7F A;  3NZ4 A;  3UNV A;  2O7E A;  1JSW A;  1HY0 A;  3R6V A;  4FLC A;  4FFX A;  2J91 A;  2FUS A;  2QVE A;  3OCF A;  2RJS A;  1T6P A;  1TJU A;  3KDY A;  1C3C A;  4EEI A;  2O7B A;  1DOF A;  1GKJ A;  5F92 A;  4V2Q A;  1RE5 A;  2PTS A;  2PFM A;  1DCN A;  1YFE A;  2X75 A;  2PTQ A;  1EB4 A;  1AUW A;  3GZH A;  4HGV A;  1U16 A;  3CZO A;  1GK3 A;  1K7W A;  3R6Q A;  1T6J A;  1K62 A;  3NO9 A;  4NSL A;  2NYF A;  5D6B A;  3E04 A;  1XWO A;  3C8T A;  1FUQ A;  5F91 A;  4EFC A;  3RRP A;  4BAA A;  1KQ7 A;  1GKM A;  3KDZ A;  4APB A;  2O6Y A;  1TJV A;  2YII A;  5EYT A;  4V2R A;  1VDK A;  3RD8 A;  2VD6 A;  1B8F A;  2QGA B;  4ADL A;  2NYN A;  1HY1 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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3E04A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations