3NO9A

Crystal structure of apo fumarate hydratase from mycobacterium tuberculosis
Total Genus 167
50100150200250300350400450020406080100120140160
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
167
sequence length
460
structure length
453
Chain Sequence
SANYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDLSIEDLDRRLDVLAMAKA
50100150200250300350400450400300200100
050100150Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYS2 (18-21)TIV1 (15-18)AH4 (106-122)AH1 (30-39)TI1 (23-26)TIV2 (40-43)TI2 (91-94)AH10 (361-386)AH2 (48-68)TI3 (102-105)AH3 (73-88)TIV3 (89-92)TIV4 (92-95)TVIII1 (98-101)PH1 (129-133)AH6 (196-222)TII1 (134-137)AH5 (139-177)TIV5 (185-188)TI9 (301-304)S3 (181-186)TI4 (177-180)AH15 (451-458)S4 (189-195)AH8 (272-299)TIV8 (267-270)TI6 (255-258)S5 (223-224)TII'1 (228-231)TVIII2 (261-264)TII2 (225-228)TI5 (229-232)TII3 (234-237)TIV6 (263-266)AH9 (328-352)TI8 (265-268)TIV7 (266-269)TI7 (264-267)S7 (309-310)TVIII3 (313-316)3H2 (406-408)AH12 (411-415)AH13 (418-431)TI11 (440-443)AH14 (435-440)TIV9 (445-449)TIV10 (446-450)S1 (12-15)AH7 (240-253)S6 (259-260)O1 (326-328)TII'2 (355-358)3H1 (388-390)S8 (392-393)AH11 (395-403)Updating...
connected with : NaN
publication title Crystal Structure of apo fumarate hydratase from Mycobacterium tuberculosis
rcsb
molecule tags Lyase
source organism Mycobacterium tuberculosis
molecule keywords Fumarate hydratase class II
total genus 167
structure length 453
sequence length 460
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2010-06-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 3no9A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3no9A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3no9A02
2E9FA 3CZOA 1JSWA 3TV2A 1AUWA 3C8TA 4V2QA 1J3UA 4ADMA 1K7WA 5HW2A 2O7FA 1FUOA 4EFCA 1FUPA 1K62A 1GK3A 3UNVA 5EYVA 5EYTA 1U16A 1U15A 1GK2A 1FURA 2O7DA 1KQ7A 3RD8A 1B8FA 2NYNA 3GZHA 3NZ4A 4FLCA 1TJUA 2PTSA 2O6YA 3OCFA 4ADLA 1TJVA 4BAAA 2PTRA 4C5RA 2RJSA 3RRPA 3KDYA 4C5UA 5F91A 1XWOA 2PTQA 1YFEA 3R6QA 1I0AA 4MX2A 4NLEA 1GKMA 1Q5NA 3GTDA 1HY0A 4EEIA 4C5SA 4BABA 5F92A 4APAA 1DOFA 2NYFA 1W27A 3R6YA 1RE5A 3NO9A 2O7BA 1T6PA 1TJ7A 3E04A 2QVEA 4NSLA 1C3UA 2X75A 1FUQA 2HVGA 4V2RA 3OCEA 3R6VA 4CQ5A 1HY1A 4C6GA 1C3CA 2O78A 1YFMA 2PFMA 1T6JA 4APBA 3QBPA 2YIIA 1GKJA 5D6BA 1YISA 2O7EA 2FUSA 2J91A 1EB4A 1VDKA 1DCNA 1Y2MA 2RJRA 3BHGA 2VD6A 3KDZA 2OHYA 4FFXA 2QGAB 4HGVA 1TJWA
chains in the Genus database with same CATH superfamily
2E9FA 1XMCA 3CZOA 1JSWA 3TV2A 1Z4IA 2VL7A 1AUWA 3C8TA 4V2QA 1J3UA 4ADMA 1K7WA 5HW2A 2O7FA 1FUOA 1IW7D 4EFCA 1FUPA 1K62A 4WNLA 3F4SA 1GK3A 3CRVA 1Z4LA 3UNVA 4YIHA 5EYVA 5EYTA 4L6CA 4E88A 1U16A 5M0IA 1U15A 1GK2A 1FURA 2D27A 2O7DA 1KQ7A 3RD8A 3BWVA 1B8FA 1XMDA 2NYNA 3GZHA 3NZ4A 1MH9A 2FELA 4FLCA 1Z4QA 4IQJM 2JAOA 1TJUA 2PTSA 1Z4PX 2O6YA 2YV5A 1XL8A 3OCFA 2JAUA 4ADLA 4YIKA 2I7DA 1TJVA 3F4TA 4BAAA 4MWOA 2PTRA 4C5RA 1Z4MA 2RJSA 3CI0K 3RRPA 1Z4KA 1U0LA 3KDYA 4C5UA 5F91A 1XWOA 2PTQA 1YFEA 3R6QA 1I0AA 4MX2A 4NLEA 1GKMA 1Q5NA 3GTDA 4NFLA 5M0JA 1HY0A 1T9HA 3F4RA 4EEIA 4BABA 4C5SA 5F92A 1XL7A 4APAA 1DOFA 2NYFA 1W27A 2RCNA 3U19A 3R6YA 4MUMA 1RE5A 3NO9A 2O7BA 1T6PA 1Z4JA 1TJ7A 3E04A 2QVEA 4NSLA 2D28C 1C3UA 2X75A 1FUQA 4L57A 2HVGA 4V2RA 3OCEA 3R6VA 4CQ5A 1HY1A 4C6GA 5H8WA 1C3CA 2O78A 1YFMA 2PFMA 1T6JA 4APBA 3QBPA 2YIIA 1GKJA 2JAWA 5D6BA 1YISA 2O7EA 2FUSA 2J91A 1EB4A 1VDKA 2VSFA 1DCNA 1Y2MA 2RJRA 3BHGA 2VD6A 4A15A 1Q91A 3U13A 3CRW1 3KDZA 4L6AA 2OHYA 2FENA 4FFXA 1XLYA 2JARA 1Q92A 2QGAB 4HGVA 1TJWA
chains in the Genus database with same CATH topology
2E9FA 3CZOA 1JSWA 3TV2A 1AUWA 3C8TA 4V2QA 1J3UA 4ADMA 1K7WA 5HW2A 2O7FA 1FUOA 4EFCA 1FUPA 1K62A 1GK3A 3UNVA 5EYVA 5EYTA 1U16A 1U15A 1GK2A 1FURA 2O7DA 1KQ7A 3RD8A 1B8FA 2NYNA 3GZHA 3NZ4A 4FLCA 1TJUA 2PTSA 2O6YA 3OCFA 4ADLA 1TJVA 4BAAA 2PTRA 4C5RA 2RJSA 3RRPA 3KDYA 4C5UA 5F91A 1XWOA 2PTQA 1YFEA 3R6QA 1I0AA 4MX2A 4NLEA 1GKMA 1Q5NA 3GTDA 1HY0A 4EEIA 4C5SA 4BABA 5F92A 4APAA 1DOFA 2NYFA 1W27A 3R6YA 1RE5A 3NO9A 2O7BA 1T6PA 1TJ7A 3E04A 2QVEA 4NSLA 1C3UA 2X75A 1FUQA 2HVGA 4V2RA 3OCEA 3R6VA 4CQ5A 1HY1A 4C6GA 1C3CA 2O78A 1YFMA 2PFMA 1T6JA 4APBA 3QBPA 2YIIA 1GKJA 5D6BA 1YISA 2O7EA 2FUSA 2J91A 1EB4A 1VDKA 1DCNA 1Y2MA 2RJRA 3BHGA 2VD6A 3KDZA 2OHYA 4FFXA 2QGAB 4HGVA 1TJWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2E9F A;  3CZO A;  1JSW A;  3TV2 A;  1AUW A;  3C8T A;  4V2Q A;  1J3U A;  4ADM A;  1K7W A;  5HW2 A;  2O7F A;  1FUO A;  4EFC A;  1FUP A;  1K62 A;  1GK3 A;  3UNV A;  5EYV A;  5EYT A;  1U16 A;  1U15 A;  1GK2 A;  1FUR A;  2O7D A;  1KQ7 A;  3RD8 A;  1B8F A;  2NYN A;  3GZH A;  3NZ4 A;  4FLC A;  1TJU A;  2PTS A;  2O6Y A;  3OCF A;  4ADL A;  1TJV A;  4BAA A;  2PTR A;  4C5R A;  2RJS A;  3RRP A;  3KDY A;  4C5U A;  5F91 A;  1XWO A;  2PTQ A;  1YFE A;  3R6Q A;  1I0A A;  4MX2 A;  4NLE A;  1GKM A;  1Q5N A;  3GTD A;  1HY0 A;  4EEI A;  4C5S A;  4BAB A;  5F92 A;  4APA A;  1DOF A;  2NYF A;  1W27 A;  3R6Y A;  1RE5 A;  3NO9 A;  2O7B A;  1T6P A;  1TJ7 A;  3E04 A;  2QVE A;  4NSL A;  1C3U A;  2X75 A;  1FUQ A;  2HVG A;  4V2R A;  3OCE A;  3R6V A;  4CQ5 A;  1HY1 A;  4C6G A;  1C3C A;  2O78 A;  1YFM A;  2PFM A;  1T6J A;  4APB A;  3QBP A;  2YII A;  1GKJ A;  5D6B A;  1YIS A;  2O7E A;  2FUS A;  2J91 A;  1EB4 A;  1VDK A;  1DCN A;  1Y2M A;  2RJR A;  3BHG A;  2VD6 A;  3KDZ A;  2OHY A;  4FFX A;  2QGA B;  4HGV A;  1TJW A; 
#chains in the Genus database with same CATH topology
 2E9F A;  1XMC A;  3CZO A;  1JSW A;  3TV2 A;  1Z4I A;  2VL7 A;  1AUW A;  3C8T A;  4V2Q A;  1J3U A;  4ADM A;  1K7W A;  5HW2 A;  2O7F A;  1FUO A;  1IW7 D;  4EFC A;  1FUP A;  1K62 A;  4WNL A;  3F4S A;  1GK3 A;  3CRV A;  1Z4L A;  3UNV A;  4YIH A;  5EYV A;  5EYT A;  4L6C A;  4E88 A;  1U16 A;  5M0I A;  1U15 A;  1GK2 A;  1FUR A;  2D27 A;  2O7D A;  1KQ7 A;  3RD8 A;  3BWV A;  1B8F A;  1XMD A;  2NYN A;  3GZH A;  3NZ4 A;  1MH9 A;  2FEL A;  4FLC A;  1Z4Q A;  4IQJ M;  2JAO A;  1TJU A;  2PTS A;  1Z4P X;  2O6Y A;  2YV5 A;  1XL8 A;  3OCF A;  2JAU A;  4ADL A;  4YIK A;  2I7D A;  1TJV A;  3F4T A;  4BAA A;  4MWO A;  2PTR A;  4C5R A;  1Z4M A;  2RJS A;  3CI0 K;  3RRP A;  1Z4K A;  1U0L A;  3KDY A;  4C5U A;  5F91 A;  1XWO A;  2PTQ A;  1YFE A;  3R6Q A;  1I0A A;  4MX2 A;  4NLE A;  1GKM A;  1Q5N A;  3GTD A;  4NFL A;  5M0J A;  1HY0 A;  1T9H A;  3F4R A;  4EEI A;  4BAB A;  4C5S A;  5F92 A;  1XL7 A;  4APA A;  1DOF A;  2NYF A;  1W27 A;  2RCN A;  3U19 A;  3R6Y A;  4MUM A;  1RE5 A;  3NO9 A;  2O7B A;  1T6P A;  1Z4J A;  1TJ7 A;  3E04 A;  2QVE A;  4NSL A;  2D28 C;  1C3U A;  2X75 A;  1FUQ A;  4L57 A;  2HVG A;  4V2R A;  3OCE A;  3R6V A;  4CQ5 A;  1HY1 A;  4C6G A;  5H8W A;  1C3C A;  2O78 A;  1YFM A;  2PFM A;  1T6J A;  4APB A;  3QBP A;  2YII A;  1GKJ A;  2JAW A;  5D6B A;  1YIS A;  2O7E A;  2FUS A;  2J91 A;  1EB4 A;  1VDK A;  2VSF A;  1DCN A;  1Y2M A;  2RJR A;  3BHG A;  2VD6 A;  4A15 A;  1Q91 A;  3U13 A;  3CRW 1;  3KDZ A;  4L6A A;  2OHY A;  2FEN A;  4FFX A;  1XLY A;  2JAR A;  1Q92 A;  2QGA B;  4HGV A;  1TJW A; 
#chains in the Genus database with same CATH homology
 2E9F A;  3CZO A;  1JSW A;  3TV2 A;  1AUW A;  3C8T A;  4V2Q A;  1J3U A;  4ADM A;  1K7W A;  5HW2 A;  2O7F A;  1FUO A;  4EFC A;  1FUP A;  1K62 A;  1GK3 A;  3UNV A;  5EYV A;  5EYT A;  1U16 A;  1U15 A;  1GK2 A;  1FUR A;  2O7D A;  1KQ7 A;  3RD8 A;  1B8F A;  2NYN A;  3GZH A;  3NZ4 A;  4FLC A;  1TJU A;  2PTS A;  2O6Y A;  3OCF A;  4ADL A;  1TJV A;  4BAA A;  2PTR A;  4C5R A;  2RJS A;  3RRP A;  3KDY A;  4C5U A;  5F91 A;  1XWO A;  2PTQ A;  1YFE A;  3R6Q A;  1I0A A;  4MX2 A;  4NLE A;  1GKM A;  1Q5N A;  3GTD A;  1HY0 A;  4EEI A;  4C5S A;  4BAB A;  5F92 A;  4APA A;  1DOF A;  2NYF A;  1W27 A;  3R6Y A;  1RE5 A;  3NO9 A;  2O7B A;  1T6P A;  1TJ7 A;  3E04 A;  2QVE A;  4NSL A;  1C3U A;  2X75 A;  1FUQ A;  2HVG A;  4V2R A;  3OCE A;  3R6V A;  4CQ5 A;  1HY1 A;  4C6G A;  1C3C A;  2O78 A;  1YFM A;  2PFM A;  1T6J A;  4APB A;  3QBP A;  2YII A;  1GKJ A;  5D6B A;  1YIS A;  2O7E A;  2FUS A;  2J91 A;  1EB4 A;  1VDK A;  1DCN A;  1Y2M A;  2RJR A;  3BHG A;  2VD6 A;  3KDZ A;  2OHY A;  4FFX A;  2QGA B;  4HGV A;  1TJW A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

Application loaded.