3PIOS

Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
175
structure length
175
Chain Sequence
MELTAKPRTPKQKLDESMIAAVAYNKENNVSFALDRKAFDRAFRQQSTTGLFDITVEGGETFPALVKAVQMDKRKRAPIHVDFYMVTYGEPVEVSVPVHTTGRSQGEVQGGLVDIVVHNLQIVAPGPRRIPQELVVDVTKMNIGDHITAGDIKLPEGCTLAADPELTVVSVLPPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit.
pubmed doi rcsb
molecule tags Ribosome/antibiotic
molecule keywords RIBOSOMAL 23S RNA
total genus 14
structure length 175
sequence length 175
ec nomenclature
pdb deposition date 2010-11-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 3pioS01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 3pioS02
3PIOS 1D6KA 5DM6S 1O0CA 1NYLA 5GAHW 5HL7S 2RD2A 5DM7S 4IOAS 1FEUA 2RE8A 4WFAS 1EUYA 4WCES 4WF9S 1ZJWA 1EUQA 2ZJPS 5JVHS 4JXXA 4UY88 4WFNS 2ZJQS 4H3SA 1QRTA 5JVGS 3J7ZV 4P2BA 5IZNA 1DFUP 2HZ7A 3DLLS 1EXDA 5GADW 4U67S 2ZJRS 3AIIA 1GTRA 1QRUA 1QRSA 4JXZA 1B75A 4WFBS 4JYZA 1QTQA 5GAEW 5BNZA 4IO9S 5GAGW 3PIPS 1O0BA 4IOCS 3CF5S 1GTSA
chains in the Genus database with same CATH superfamily
5IYBC 2L5NA 1I50C 4LK0A 4LJZA 2PNWA 1O0CA 3K7AC 5IYCC 3PO3C 2G6GA 2WB1D 3S17C 5HQHA 3FKIC 2ZJPS 4UY88 4JXXA 3GTMC 2R93C 3GTPC 1IW7A 4OIPA 2A68A 4A3IC 3GTGC 3S1NC 3S1QC 1V6ZA 4OINA 2L3UA 4J3CA 1ZYRA 4LLGA 1B75A 4JXZA 3AIIA 4MQ9A 2PA8D 5TMFA 5C3EC 2EGVA 1R9TC 4JYZA 5GAEW 1I6HC 2JA8C 1Z85A 2NVYC 4AYBD 4G7OA 4L69A 4A3DC 1UDXA 4A93C 2Z0YA 2JA7C 3HOWC 3S14C 3PIOS 2KXYA 5DM6S 1NYLA 5GAHW 5HL7S 4ZH4A 2O5IA 4QIWD 4YFKA 3HOZC 2JA5C 4KN4A 4WCES 4X6AC 4A3KC 4A3FC 2G5DA 1ZJWA 1EUQA 2Y0SD 3DXJA 3S15C 2CX8A 4H3SA 3M3YC 4C3JC 1VHYA 1K83C 4KMUA 2B63C 2WAQD 4C3HC 4BXXC 4BBRC 5IZNA 2PICA 1DFUP 4NOIA 4Q5SA 4MEYA 3CZBA 4XLNA 2PMZD 3RZDC 4Q4ZA 2NVXC 3GTLC 4U67S 3HOUC 3I4NC 3W2VB 5FLMC 1QTQA 4Y52C 1I3QC 3PIPS 2A6HA 3W2WB 3S1MC 3EQLA 2E2JC 4OIOA 2A6EA 4Y7NC 4GZYA 3HOXC 4V194 4XLPA 4BY1C 5C4JC 2VUMC 2O5JA 1TWCC 2NVTC 3GTJC 2NVQC 3PO2C 2BE5A 4BBSC 2E2IC 5IP7C 1HQMA 5JVHS 2CW0A 4YFNA 4WFNS 2ZJQS 2JA6C 4G7HA 3S2DC 4A3CC 3J7ZV 3GTOC 5TMCA 4P2BA 4XSZA 4MEXA 4G7ZA 2R92C 3KW2A 4QJVA 3HOYC 2HZ7A 4C3IC 3DLLS 3I4MC 1I6VA 4XSXA 4A3JC 1EXDA 5GADW 1WCMC 1QRSA 1QRUA 3LYWA 1SFOC 2E2HC 2AE0X 4WFBS 2R7ZC 4YG2A 5IP9C 5BNZA 5D4DA 4A3EC 2A69A 5GAGW 3HKZD 4BY7C 3CF5S 2PJJA 2PPBA 1GTSA 4KN7A 1TWGC 1D6KA 4JK1A 1YNJA 2RD2A 1YNNA 5DM7S 4IOAS 1FEUA 2PI8A 4WFAS 2RE8A 1BDFA 1SMYA 1EUYA 2YU9C 1TWFC 4C2MC 4A3GC 1NXZA 4E8BA 4WF9S 4H4KA 4YFXA 3GTQC 1VHKA 5IYDC 3S16C 4OIRA 1QRTA 5JVGS 2KPUA 4LK1A 3H3VD 3RZOC 1TWAC 2EGWA 3M4OC 3S1RC 2ZJRS 3GTKC 1GTRA 3WODA 3HOVC 2NWAA 4IO9S 3CQZC 4A3LC 4A3BC 1O0BA 3H0GC 4IOCS 3X1LB 5C44C 1TWHC 5C4XC 1Y1WC 2KQ1A 3S2HC 4OIQA 1Y1VC 4A3MC 2GAEA
chains in the Genus database with same CATH topology
3PIOS 1D6KA 5DM6S 1O0CA 1NYLA 5GAHW 5HL7S 2RD2A 5DM7S 4IOAS 1FEUA 2RE8A 4WFAS 1EUYA 4WCES 4WF9S 4H4KA 1ZJWA 1EUQA 2ZJPS 5JVHS 4JXXA 4UY88 4WFNS 2ZJQS 4H3SA 1QRTA 5JVGS 3J7ZV 4P2BA 5IZNA 1DFUP 2HZ7A 3DLLS 1EXDA 5GADW 4U67S 2ZJRS 3AIIA 1GTRA 1QRUA 1QRSA 4JXZA 1B75A 3W2VB 4WFBS 4JYZA 1QTQA 5GAEW 5BNZA 4IO9S 5GAGW 3PIPS 3W2WB 1O0BA 4IOCS 3X1LB 3CF5S 1GTSA 1UDXA 4V194
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3PIO S;  1D6K A;  5DM6 S;  1O0C A;  1NYL A;  5GAH W;  5HL7 S;  2RD2 A;  5DM7 S;  4IOA S;  1FEU A;  2RE8 A;  4WFA S;  1EUY A;  4WCE S;  4WF9 S;  1ZJW A;  1EUQ A;  2ZJP S;  5JVH S;  4JXX A;  4UY8 8;  4WFN S;  2ZJQ S;  4H3S A;  1QRT A;  5JVG S;  3J7Z V;  4P2B A;  5IZN A;  1DFU P;  2HZ7 A;  3DLL S;  1EXD A;  5GAD W;  4U67 S;  2ZJR S;  3AII A;  1GTR A;  1QRU A;  1QRS A;  4JXZ A;  1B75 A;  4WFB S;  4JYZ A;  1QTQ A;  5GAE W;  5BNZ A;  4IO9 S;  5GAG W;  3PIP S;  1O0B A;  4IOC S;  3CF5 S;  1GTS A; 
#chains in the Genus database with same CATH topology
 5IYB C;  2L5N A;  1I50 C;  4LK0 A;  4LJZ A;  2PNW A;  1O0C A;  3K7A C;  5IYC C;  3PO3 C;  2G6G A;  2WB1 D;  3S17 C;  5HQH A;  3FKI C;  2ZJP S;  4UY8 8;  4JXX A;  3GTM C;  2R93 C;  3GTP C;  1IW7 A;  4OIP A;  2A68 A;  4A3I C;  3GTG C;  3S1N C;  3S1Q C;  1V6Z A;  4OIN A;  2L3U A;  4J3C A;  1ZYR A;  4LLG A;  1B75 A;  4JXZ A;  3AII A;  4MQ9 A;  2PA8 D;  5TMF A;  5C3E C;  2EGV A;  1R9T C;  4JYZ A;  5GAE W;  1I6H C;  2JA8 C;  1Z85 A;  2NVY C;  4AYB D;  4G7O A;  4L69 A;  4A3D C;  1UDX A;  4A93 C;  2Z0Y A;  2JA7 C;  3HOW C;  3S14 C;  3PIO S;  2KXY A;  5DM6 S;  1NYL A;  5GAH W;  5HL7 S;  4ZH4 A;  2O5I A;  4QIW D;  4YFK A;  3HOZ C;  2JA5 C;  4KN4 A;  4WCE S;  4X6A C;  4A3K C;  4A3F C;  2G5D A;  1ZJW A;  1EUQ A;  2Y0S D;  3DXJ A;  3S15 C;  2CX8 A;  4H3S A;  3M3Y C;  4C3J C;  1VHY A;  1K83 C;  4KMU A;  2B63 C;  2WAQ D;  4C3H C;  4BXX C;  4BBR C;  5IZN A;  2PIC A;  1DFU P;  4NOI A;  4Q5S A;  4MEY A;  3CZB A;  4XLN A;  2PMZ D;  3RZD C;  4Q4Z A;  2NVX C;  3GTL C;  4U67 S;  3HOU C;  3I4N C;  3W2V B;  5FLM C;  1QTQ A;  4Y52 C;  1I3Q C;  3PIP S;  2A6H A;  3W2W B;  3S1M C;  3EQL A;  2E2J C;  4OIO A;  2A6E A;  4Y7N C;  4GZY A;  3HOX C;  4V19 4;  4XLP A;  4BY1 C;  5C4J C;  2VUM C;  2O5J A;  1TWC C;  2NVT C;  3GTJ C;  2NVQ C;  3PO2 C;  2BE5 A;  4BBS C;  2E2I C;  5IP7 C;  1HQM A;  5JVH S;  2CW0 A;  4YFN A;  4WFN S;  2ZJQ S;  2JA6 C;  4G7H A;  3S2D C;  4A3C C;  3J7Z V;  3GTO C;  5TMC A;  4P2B A;  4XSZ A;  4MEX A;  4G7Z A;  2R92 C;  3KW2 A;  4QJV A;  3HOY C;  2HZ7 A;  4C3I C;  3DLL S;  3I4M C;  1I6V A;  4XSX A;  4A3J C;  1EXD A;  5GAD W;  1WCM C;  1QRS A;  1QRU A;  3LYW A;  1SFO C;  2E2H C;  2AE0 X;  4WFB S;  2R7Z C;  4YG2 A;  5IP9 C;  5BNZ A;  5D4D A;  4A3E C;  2A69 A;  5GAG W;  3HKZ D;  4BY7 C;  3CF5 S;  2PJJ A;  2PPB A;  1GTS A;  4KN7 A;  1TWG C;  1D6K A;  4JK1 A;  1YNJ A;  2RD2 A;  1YNN A;  5DM7 S;  4IOA S;  1FEU A;  2PI8 A;  4WFA S;  2RE8 A;  1BDF A;  1SMY A;  1EUY A;  2YU9 C;  1TWF C;  4C2M C;  4A3G C;  1NXZ A;  4E8B A;  4WF9 S;  4H4K A;  4YFX A;  3GTQ C;  1VHK A;  5IYD C;  3S16 C;  4OIR A;  1QRT A;  5JVG S;  2KPU A;  4LK1 A;  3H3V D;  3RZO C;  1TWA C;  2EGW A;  3M4O C;  3S1R C;  2ZJR S;  3GTK C;  1GTR A;  3WOD A;  3HOV C;  2NWA A;  4IO9 S;  3CQZ C;  4A3L C;  4A3B C;  1O0B A;  3H0G C;  4IOC S;  3X1L B;  5C44 C;  1TWH C;  5C4X C;  1Y1W C;  2KQ1 A;  3S2H C;  4OIQ A;  1Y1V C;  4A3M C;  2GAE A; 
#chains in the Genus database with same CATH homology
 3PIO S;  1D6K A;  5DM6 S;  1O0C A;  1NYL A;  5GAH W;  5HL7 S;  2RD2 A;  5DM7 S;  4IOA S;  1FEU A;  2RE8 A;  4WFA S;  1EUY A;  4WCE S;  4WF9 S;  4H4K A;  1ZJW A;  1EUQ A;  2ZJP S;  5JVH S;  4JXX A;  4UY8 8;  4WFN S;  2ZJQ S;  4H3S A;  1QRT A;  5JVG S;  3J7Z V;  4P2B A;  5IZN A;  1DFU P;  2HZ7 A;  3DLL S;  1EXD A;  5GAD W;  4U67 S;  2ZJR S;  3AII A;  1GTR A;  1QRU A;  1QRS A;  4JXZ A;  1B75 A;  3W2V B;  4WFB S;  4JYZ A;  1QTQ A;  5GAE W;  5BNZ A;  4IO9 S;  5GAG W;  3PIP S;  3W2W B;  1O0B A;  4IOC S;  3X1L B;  3CF5 S;  1GTS A;  1UDX A;  4V19 4; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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