3PIPS

Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
175
structure length
175
Chain Sequence
MELTAKPRTPKQKLDESMIAAVAYNKENNVSFALDRKAFDRAFRQQSTTGLFDITVEGGETFPALVKAVQMDKRKRAPIHVDFYMVTYGEPVEVSVPVHTTGRSQGEVQGGLVDIVVHNLQIVAPGPRRIPQELVVDVTKMNIGDHITAGDIKLPEGCTLAADPELTVVSVLPPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit.
pubmed doi rcsb
molecule tags Ribosome/antibiotic
molecule keywords RIBOSOMAL 23S RNA
total genus 15
structure length 175
sequence length 175
ec nomenclature
pdb deposition date 2010-11-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 3pipS01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 3pipS02
3J7ZV 5GAEW 1EXDA 1QRSA 4IOAS 4WFBS 5JVGS 2ZJRS 4WCES 2ZJPS 4UY88 1O0BA 1EUYA 5IZNA 1GTRA 3AIIA 5HL7S 5BNZA 1GTSA 1DFUP 4WF9S 4WFAS 1FEUA 4U67S 5GADW 5JVHS 1ZJWA 2RD2A 5DM7S 4P2BA 5GAHW 1QRTA 2HZ7A 1QRUA 5GAGW 3DLLS 4H3SA 5DM6S 4JYZA 1D6KA 1B75A 2ZJQS 3PIPS 4JXZA 1QTQA 4JXXA 1NYLA 2RE8A 4IO9S 4IOCS 1EUQA 1O0CA 3CF5S 3PIOS 4WFNS
chains in the Genus database with same CATH superfamily
4Q4ZA 1ZYRA 5IYBC 1SMYA 2E2HC 1QRSA 3KW2A 4WFBS 4KMUA 2ZJRS 2GAEA 5C3EC 2L5NA 4YFNA 3HOVC 2NVXC 1EUYA 2A6EA 4A3EC 4XSZA 1GTRA 3RZDC 3S2HC 2PPBA 3HOYC 4WF9S 1V6ZA 4XSXA 3HOZC 3S14C 1ZJWA 2PJJA 2PA8D 1QRUA 3DXJA 1SFOC 2O5IA 4JYZA 1D6KA 3K7AC 4LK0A 5IP9C 4C3HC 5TMCA 4A3MC 3S1QC 2BE5A 2JA6C 1TWHC 1QTQA 4C3JC 3WODA 2L3UA 2KXYA 3GTOC 3EQLA 4QJVA 4YG2A 5IP7C 4OIQA 2NWAA 2NVQC 1WCMC 4X6AC 2NVYC 2E2IC 5C4JC 1I6VA 4KN4A 4BBRC 3HOXC 1EXDA 4BY7C 2Y0SD 3M3YC 2R93C 5JVGS 3M4OC 1TWFC 3HOWC 2PICA 2ZJPS 4UY88 2KPUA 4J3CA 3I4NC 4H4KA 1YNJA 2A6HA 1Y1WC 4A3FC 5IYDC 5HL7S 1GTSA 4OIOA 2JA8C 4WFAS 1FEUA 4LK1A 4U67S 3H3VD 4E8BA 5GAHW 1IW7A 1R9TC 4H3SA 5DM6S 3X1LB 2KQ1A 4A3JC 3GTPC 2AE0X 3PIPS 4A3LC 4XLPA 4JXZA 4Y52C 3S1MC 1NYLA 2EGVA 4OIPA 3HKZD 4IOCS 4MQ9A 3W2WB 3RZOC 3CF5S 2PI8A 1K83C 4C3IC 2PNWA 4OIRA 2WAQD 3J7ZV 2B63C 5GAEW 1I50C 5D4DA 4A3DC 4WCES 3S1NC 3S17C 1O0BA 2VUMC 5IZNA 4BY1C 4NOIA 2JA7C 3GTLC 1DFUP 5BNZA 4KN7A 5IYCC 3I4MC 4A3BC 1Y1VC 1I6HC 4OINA 5JVHS 3S1RC 4AYBD 3GTGC 4A93C 4JK1A 5DM7S 4GZYA 1QRTA 4L69A 3H0GC 5GAGW 3W2VB 5C44C 5FLMC 3S16C 1B75A 3PO3C 4Q5SA 2WB1D 4LLGA 2YU9C 3GTQC 2CX8A 4XLNA 3PO2C 3HOUC 2A68A 4QIWD 4ZH4A 2G5DA 2RE8A 4C2MC 2EGWA 1HQMA 2CW0A 3GTJC 1BDFA 3PIOS 2E2JC 4WFNS 3GTKC 3CZBA 1VHKA 1NXZA 2R7ZC 4IOAS 1I3QC 1TWGC 5TMFA 4G7OA 2O5JA 2NVTC 2G6GA 3FKIC 3LYWA 4A3CC 2JA5C 4BBSC 4A3KC 3AIIA 1Z85A 4YFXA 2Z0YA 4A3GC 1UDXA 5GADW 2R92C 4BXXC 4P2BA 2PMZD 2HZ7A 4MEYA 3S2DC 4Y7NC 1VHYA 3GTMC 3DLLS 4G7HA 4G7ZA 2ZJQS 3CQZC 4V194 1TWCC 4JXXA 5HQHA 2A69A 4YFKA 4A3IC 5C4XC 4MEXA 4IO9S 1EUQA 1TWAC 4LJZA 1O0CA 2RD2A 1YNNA 3S15C
chains in the Genus database with same CATH topology
3J7ZV 5GAEW 1EXDA 1QRSA 4IOAS 4WFBS 5JVGS 2ZJRS 4WCES 2ZJPS 4UY88 1O0BA 1EUYA 4H4KA 5IZNA 1GTRA 3AIIA 5HL7S 5BNZA 1GTSA 1DFUP 4WF9S 4WFAS 1FEUA 1UDXA 5GADW 4U67S 5JVHS 1ZJWA 2RD2A 5DM7S 4P2BA 5GAHW 1QRTA 2HZ7A 1QRUA 5GAGW 3W2VB 3DLLS 4H3SA 5DM6S 4JYZA 1D6KA 3X1LB 1B75A 2ZJQS 3PIPS 4JXZA 1QTQA 4V194 4JXXA 1NYLA 2RE8A 4IO9S 4IOCS 1EUQA 3W2WB 1O0CA 3CF5S 3PIOS 4WFNS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3J7Z V;  5GAE W;  1EXD A;  1QRS A;  4IOA S;  4WFB S;  5JVG S;  2ZJR S;  4WCE S;  2ZJP S;  4UY8 8;  1O0B A;  1EUY A;  5IZN A;  1GTR A;  3AII A;  5HL7 S;  5BNZ A;  1GTS A;  1DFU P;  4WF9 S;  4WFA S;  1FEU A;  4U67 S;  5GAD W;  5JVH S;  1ZJW A;  2RD2 A;  5DM7 S;  4P2B A;  5GAH W;  1QRT A;  2HZ7 A;  1QRU A;  5GAG W;  3DLL S;  4H3S A;  5DM6 S;  4JYZ A;  1D6K A;  1B75 A;  2ZJQ S;  3PIP S;  4JXZ A;  1QTQ A;  4JXX A;  1NYL A;  2RE8 A;  4IO9 S;  4IOC S;  1EUQ A;  1O0C A;  3CF5 S;  3PIO S;  4WFN S; 
#chains in the Genus database with same CATH topology
 4Q4Z A;  1ZYR A;  5IYB C;  1SMY A;  2E2H C;  1QRS A;  3KW2 A;  4WFB S;  4KMU A;  2ZJR S;  2GAE A;  5C3E C;  2L5N A;  4YFN A;  3HOV C;  2NVX C;  1EUY A;  2A6E A;  4A3E C;  4XSZ A;  1GTR A;  3RZD C;  3S2H C;  2PPB A;  3HOY C;  4WF9 S;  1V6Z A;  4XSX A;  3HOZ C;  3S14 C;  1ZJW A;  2PJJ A;  2PA8 D;  1QRU A;  3DXJ A;  1SFO C;  2O5I A;  4JYZ A;  1D6K A;  3K7A C;  4LK0 A;  5IP9 C;  4C3H C;  5TMC A;  4A3M C;  3S1Q C;  2BE5 A;  2JA6 C;  1TWH C;  1QTQ A;  4C3J C;  3WOD A;  2L3U A;  2KXY A;  3GTO C;  3EQL A;  4QJV A;  4YG2 A;  5IP7 C;  4OIQ A;  2NWA A;  2NVQ C;  1WCM C;  4X6A C;  2NVY C;  2E2I C;  5C4J C;  1I6V A;  4KN4 A;  4BBR C;  3HOX C;  1EXD A;  4BY7 C;  2Y0S D;  3M3Y C;  2R93 C;  5JVG S;  3M4O C;  1TWF C;  3HOW C;  2PIC A;  2ZJP S;  4UY8 8;  2KPU A;  4J3C A;  3I4N C;  4H4K A;  1YNJ A;  2A6H A;  1Y1W C;  4A3F C;  5IYD C;  5HL7 S;  1GTS A;  4OIO A;  2JA8 C;  4WFA S;  1FEU A;  4LK1 A;  4U67 S;  3H3V D;  4E8B A;  5GAH W;  1IW7 A;  1R9T C;  4H3S A;  5DM6 S;  3X1L B;  2KQ1 A;  4A3J C;  3GTP C;  2AE0 X;  3PIP S;  4A3L C;  4XLP A;  4JXZ A;  4Y52 C;  3S1M C;  1NYL A;  2EGV A;  4OIP A;  3HKZ D;  4IOC S;  4MQ9 A;  3W2W B;  3RZO C;  3CF5 S;  2PI8 A;  1K83 C;  4C3I C;  2PNW A;  4OIR A;  2WAQ D;  3J7Z V;  2B63 C;  5GAE W;  1I50 C;  5D4D A;  4A3D C;  4WCE S;  3S1N C;  3S17 C;  1O0B A;  2VUM C;  5IZN A;  4BY1 C;  4NOI A;  2JA7 C;  3GTL C;  1DFU P;  5BNZ A;  4KN7 A;  5IYC C;  3I4M C;  4A3B C;  1Y1V C;  1I6H C;  4OIN A;  5JVH S;  3S1R C;  4AYB D;  3GTG C;  4A93 C;  4JK1 A;  5DM7 S;  4GZY A;  1QRT A;  4L69 A;  3H0G C;  5GAG W;  3W2V B;  5C44 C;  5FLM C;  3S16 C;  1B75 A;  3PO3 C;  4Q5S A;  2WB1 D;  4LLG A;  2YU9 C;  3GTQ C;  2CX8 A;  4XLN A;  3PO2 C;  3HOU C;  2A68 A;  4QIW D;  4ZH4 A;  2G5D A;  2RE8 A;  4C2M C;  2EGW A;  1HQM A;  2CW0 A;  3GTJ C;  1BDF A;  3PIO S;  2E2J C;  4WFN S;  3GTK C;  3CZB A;  1VHK A;  1NXZ A;  2R7Z C;  4IOA S;  1I3Q C;  1TWG C;  5TMF A;  4G7O A;  2O5J A;  2NVT C;  2G6G A;  3FKI C;  3LYW A;  4A3C C;  2JA5 C;  4BBS C;  4A3K C;  3AII A;  1Z85 A;  4YFX A;  2Z0Y A;  4A3G C;  1UDX A;  5GAD W;  2R92 C;  4BXX C;  4P2B A;  2PMZ D;  2HZ7 A;  4MEY A;  3S2D C;  4Y7N C;  1VHY A;  3GTM C;  3DLL S;  4G7H A;  4G7Z A;  2ZJQ S;  3CQZ C;  4V19 4;  1TWC C;  4JXX A;  5HQH A;  2A69 A;  4YFK A;  4A3I C;  5C4X C;  4MEX A;  4IO9 S;  1EUQ A;  1TWA C;  4LJZ A;  1O0C A;  2RD2 A;  1YNN A;  3S15 C; 
#chains in the Genus database with same CATH homology
 3J7Z V;  5GAE W;  1EXD A;  1QRS A;  4IOA S;  4WFB S;  5JVG S;  2ZJR S;  4WCE S;  2ZJP S;  4UY8 8;  1O0B A;  1EUY A;  4H4K A;  5IZN A;  1GTR A;  3AII A;  5HL7 S;  5BNZ A;  1GTS A;  1DFU P;  4WF9 S;  4WFA S;  1FEU A;  1UDX A;  5GAD W;  4U67 S;  5JVH S;  1ZJW A;  2RD2 A;  5DM7 S;  4P2B A;  5GAH W;  1QRT A;  2HZ7 A;  1QRU A;  5GAG W;  3W2V B;  3DLL S;  4H3S A;  5DM6 S;  4JYZ A;  1D6K A;  3X1L B;  1B75 A;  2ZJQ S;  3PIP S;  4JXZ A;  1QTQ A;  4V19 4;  4JXX A;  1NYL A;  2RE8 A;  4IO9 S;  4IOC S;  1EUQ A;  3W2W B;  1O0C A;  3CF5 S;  3PIO S;  4WFN S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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