3DLLS

The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect trna positioning
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
175
structure length
175
Chain Sequence
MELTAKPRTPKQKLDESMIAAVAYNKENNVSFALDRKAFDRAFRQQSTTGLFDITVEGGETFPALVKAVQMDKRKRAPIHVDFYMVTYGEPVEVSVPVHTTGRSQGEVQGGLVDIVVHNLQIVAPGPRRIPQELVVDVTKMNIGDHITAGDIKLPEGCTLAADPELTVVSVLPPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning
pubmed doi rcsb
molecule tags Ribosome
molecule keywords rRNA-23S ribosomal RNA
total genus 21
structure length 175
sequence length 175
ec nomenclature
pdb deposition date 2008-06-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 3dllS01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 3dllS02
5GAGW 4JXXA 1FEUA 2ZJQS 3CF5S 1DFUP 3PIOS 1QRUA 1ZJWA 3AIIA 1EUQA 4JXZA 2ZJPS 1QRTA 5DM7S 4U67S 5JVGS 4IOCS 4UY88 4JYZA 5GAEW 5BNZA 5HL7S 2HZ7A 4WFAS 1D6KA 4IO9S 4WF9S 1GTSA 4H3SA 5GADW 3PIPS 3DLLS 3J7ZV 2RE8A 2ZJRS 5GAHW 1GTRA 1NYLA 1QRSA 1QTQA 5IZNA 4P2BA 5DM6S 4IOAS 4WFNS 4WFBS 1O0CA 1B75A 5JVHS 1EUYA 4WCES 1EXDA 1O0BA 2RD2A
chains in the Genus database with same CATH superfamily
2GAEA 3LYWA 1Y1WC 2ZJQS 1DFUP 3S1NC 3PIOS 1QRTA 3CQZC 1I50C 2R7ZC 1I6HC 4YFKA 4JYZA 2BE5A 5C4XC 4L69A 3K7AC 2R93C 4WFAS 3EQLA 3I4MC 4C3IC 2B63C 2NWAA 3HOUC 1VHKA 3FKIC 1TWAC 4XLNA 5GADW 3DLLS 1UDXA 1V6ZA 5IYCC 3GTOC 4QJVA 5IP9C 1NYLA 4OIRA 3KW2A 5IZNA 2KXYA 4G7OA 4OIQA 3M4OC 4KN7A 2A68A 4MEYA 4A3DC 3PO2C 3HOYC 4Q4ZA 3DXJA 3S17C 2G6GA 2L3UA 5HQHA 1EUYA 4WF9S 4C2MC 4YFXA 2YU9C 1SFOC 2EGVA 2A6EA 2WAQD 4Q5SA 1QRUA 2PMZD 3HOWC 2NVYC 1K83C 3AIIA 4LJZA 3S15C 2AE0X 2PNWA 3X1LB 4JXZA 4YG2A 2NVTC 4XSXA 2O5IA 3RZOC 2KPUA 3S1MC 4J3CA 4U67S 5IP7C 5IYDC 5D4DA 4JK1A 3S2HC 4BBRC 4IOCS 2Y0SD 5C4JC 4XSZA 5GAEW 4BBSC 2KQ1A 2NVXC 5TMFA 5IYBC 4GZYA 4IO9S 2EGWA 4X6AC 4H3SA 2O5JA 3PIPS 4C3JC 3J7ZV 4A93C 1QTQA 1YNJA 4KMUA 4BXXC 2CW0A 4IOAS 1O0CA 4E8BA 4C3HC 3GTJC 1B75A 1Z85A 4WCES 4NOIA 1EXDA 1O0BA 5GAGW 4JXXA 2Z0YA 3GTKC 4Y7NC 4H4KA 1FEUA 4A3KC 3H0GC 4LK0A 4QIWD 3GTGC 1TWFC 3HOVC 1EUQA 3WODA 3S1RC 1SMYA 4G7HA 5JVGS 2E2HC 5BNZA 4AYBD 4A3MC 3GTQC 3M3YC 4A3LC 2HZ7A 1WCMC 1TWGC 4V194 1D6KA 2L5NA 5FLMC 1I3QC 3S16C 4ZH4A 2JA6C 2PICA 1I6VA 2RE8A 4A3FC 3H3VD 3S14C 2JA7C 4YFNA 2CX8A 3GTMC 3HOZC 2JA8C 4A3GC 3GTPC 4Y52C 3PO3C 2PI8A 4WFNS 4WFBS 2G5DA 3S1QC 1VHYA 2NVQC 5C3EC 4XLPA 4OIPA 2WB1D 5C44C 3CF5S 2PA8D 3HKZD 3CZBA 1IW7A 2A6HA 1ZJWA 1R9TC 4A3EC 4LLGA 4A3JC 4A3CC 3HOXC 2ZJPS 5TMCA 2E2IC 4BY1C 5DM7S 2VUMC 3S2DC 2A69A 4A3IC 2PJJA 3W2WB 4LK1A 4UY88 3RZDC 5HL7S 4OIOA 1ZYRA 2JA5C 4KN4A 2R92C 4MQ9A 4A3BC 1GTSA 3GTLC 2PPBA 1Y1VC 2ZJRS 1TWCC 5GAHW 1GTRA 1QRSA 2E2JC 3I4NC 1HQMA 4P2BA 5DM6S 4BY7C 4MEXA 1YNNA 1NXZA 3W2VB 1BDFA 4OINA 4G7ZA 1TWHC 5JVHS 2RD2A
chains in the Genus database with same CATH topology
5GAGW 4JXXA 4H4KA 1FEUA 2ZJQS 3CF5S 1DFUP 3PIOS 1QRUA 1ZJWA 3AIIA 1EUQA 3X1LB 4JXZA 2ZJPS 1QRTA 5DM7S 4U67S 5JVGS 3W2WB 4IOCS 4UY88 4JYZA 5GAEW 5BNZA 5HL7S 2HZ7A 4WFAS 4V194 1D6KA 4IO9S 4WF9S 1GTSA 4H3SA 5GADW 3PIPS 1UDXA 3DLLS 3J7ZV 2RE8A 2ZJRS 5GAHW 1GTRA 1NYLA 1QRSA 1QTQA 5IZNA 4P2BA 5DM6S 4IOAS 3W2VB 4WFNS 4WFBS 1O0CA 1B75A 5JVHS 1EUYA 4WCES 1EXDA 1O0BA 2RD2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5GAG W;  4JXX A;  1FEU A;  2ZJQ S;  3CF5 S;  1DFU P;  3PIO S;  1QRU A;  1ZJW A;  3AII A;  1EUQ A;  4JXZ A;  2ZJP S;  1QRT A;  5DM7 S;  4U67 S;  5JVG S;  4IOC S;  4UY8 8;  4JYZ A;  5GAE W;  5BNZ A;  5HL7 S;  2HZ7 A;  4WFA S;  1D6K A;  4IO9 S;  4WF9 S;  1GTS A;  4H3S A;  5GAD W;  3PIP S;  3DLL S;  3J7Z V;  2RE8 A;  2ZJR S;  5GAH W;  1GTR A;  1NYL A;  1QRS A;  1QTQ A;  5IZN A;  4P2B A;  5DM6 S;  4IOA S;  4WFN S;  4WFB S;  1O0C A;  1B75 A;  5JVH S;  1EUY A;  4WCE S;  1EXD A;  1O0B A;  2RD2 A; 
#chains in the Genus database with same CATH topology
 2GAE A;  3LYW A;  1Y1W C;  2ZJQ S;  1DFU P;  3S1N C;  3PIO S;  1QRT A;  3CQZ C;  1I50 C;  2R7Z C;  1I6H C;  4YFK A;  4JYZ A;  2BE5 A;  5C4X C;  4L69 A;  3K7A C;  2R93 C;  4WFA S;  3EQL A;  3I4M C;  4C3I C;  2B63 C;  2NWA A;  3HOU C;  1VHK A;  3FKI C;  1TWA C;  4XLN A;  5GAD W;  3DLL S;  1UDX A;  1V6Z A;  5IYC C;  3GTO C;  4QJV A;  5IP9 C;  1NYL A;  4OIR A;  3KW2 A;  5IZN A;  2KXY A;  4G7O A;  4OIQ A;  3M4O C;  4KN7 A;  2A68 A;  4MEY A;  4A3D C;  3PO2 C;  3HOY C;  4Q4Z A;  3DXJ A;  3S17 C;  2G6G A;  2L3U A;  5HQH A;  1EUY A;  4WF9 S;  4C2M C;  4YFX A;  2YU9 C;  1SFO C;  2EGV A;  2A6E A;  2WAQ D;  4Q5S A;  1QRU A;  2PMZ D;  3HOW C;  2NVY C;  1K83 C;  3AII A;  4LJZ A;  3S15 C;  2AE0 X;  2PNW A;  3X1L B;  4JXZ A;  4YG2 A;  2NVT C;  4XSX A;  2O5I A;  3RZO C;  2KPU A;  3S1M C;  4J3C A;  4U67 S;  5IP7 C;  5IYD C;  5D4D A;  4JK1 A;  3S2H C;  4BBR C;  4IOC S;  2Y0S D;  5C4J C;  4XSZ A;  5GAE W;  4BBS C;  2KQ1 A;  2NVX C;  5TMF A;  5IYB C;  4GZY A;  4IO9 S;  2EGW A;  4X6A C;  4H3S A;  2O5J A;  3PIP S;  4C3J C;  3J7Z V;  4A93 C;  1QTQ A;  1YNJ A;  4KMU A;  4BXX C;  2CW0 A;  4IOA S;  1O0C A;  4E8B A;  4C3H C;  3GTJ C;  1B75 A;  1Z85 A;  4WCE S;  4NOI A;  1EXD A;  1O0B A;  5GAG W;  4JXX A;  2Z0Y A;  3GTK C;  4Y7N C;  4H4K A;  1FEU A;  4A3K C;  3H0G C;  4LK0 A;  4QIW D;  3GTG C;  1TWF C;  3HOV C;  1EUQ A;  3WOD A;  3S1R C;  1SMY A;  4G7H A;  5JVG S;  2E2H C;  5BNZ A;  4AYB D;  4A3M C;  3GTQ C;  3M3Y C;  4A3L C;  2HZ7 A;  1WCM C;  1TWG C;  4V19 4;  1D6K A;  2L5N A;  5FLM C;  1I3Q C;  3S16 C;  4ZH4 A;  2JA6 C;  2PIC A;  1I6V A;  2RE8 A;  4A3F C;  3H3V D;  3S14 C;  2JA7 C;  4YFN A;  2CX8 A;  3GTM C;  3HOZ C;  2JA8 C;  4A3G C;  3GTP C;  4Y52 C;  3PO3 C;  2PI8 A;  4WFN S;  4WFB S;  2G5D A;  3S1Q C;  1VHY A;  2NVQ C;  5C3E C;  4XLP A;  4OIP A;  2WB1 D;  5C44 C;  3CF5 S;  2PA8 D;  3HKZ D;  3CZB A;  1IW7 A;  2A6H A;  1ZJW A;  1R9T C;  4A3E C;  4LLG A;  4A3J C;  4A3C C;  3HOX C;  2ZJP S;  5TMC A;  2E2I C;  4BY1 C;  5DM7 S;  2VUM C;  3S2D C;  2A69 A;  4A3I C;  2PJJ A;  3W2W B;  4LK1 A;  4UY8 8;  3RZD C;  5HL7 S;  4OIO A;  1ZYR A;  2JA5 C;  4KN4 A;  2R92 C;  4MQ9 A;  4A3B C;  1GTS A;  3GTL C;  2PPB A;  1Y1V C;  2ZJR S;  1TWC C;  5GAH W;  1GTR A;  1QRS A;  2E2J C;  3I4N C;  1HQM A;  4P2B A;  5DM6 S;  4BY7 C;  4MEX A;  1YNN A;  1NXZ A;  3W2V B;  1BDF A;  4OIN A;  4G7Z A;  1TWH C;  5JVH S;  2RD2 A; 
#chains in the Genus database with same CATH homology
 5GAG W;  4JXX A;  4H4K A;  1FEU A;  2ZJQ S;  3CF5 S;  1DFU P;  3PIO S;  1QRU A;  1ZJW A;  3AII A;  1EUQ A;  3X1L B;  4JXZ A;  2ZJP S;  1QRT A;  5DM7 S;  4U67 S;  5JVG S;  3W2W B;  4IOC S;  4UY8 8;  4JYZ A;  5GAE W;  5BNZ A;  5HL7 S;  2HZ7 A;  4WFA S;  4V19 4;  1D6K A;  4IO9 S;  4WF9 S;  1GTS A;  4H3S A;  5GAD W;  3PIP S;  1UDX A;  3DLL S;  3J7Z V;  2RE8 A;  2ZJR S;  5GAH W;  1GTR A;  1NYL A;  1QRS A;  1QTQ A;  5IZN A;  4P2B A;  5DM6 S;  4IOA S;  3W2V B;  4WFN S;  4WFB S;  1O0C A;  1B75 A;  5JVH S;  1EUY A;  4WCE S;  1EXD A;  1O0B A;  2RD2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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