3PIOS

Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
175
structure length
175
Chain Sequence
MELTAKPRTPKQKLDESMIAAVAYNKENNVSFALDRKAFDRAFRQQSTTGLFDITVEGGETFPALVKAVQMDKRKRAPIHVDFYMVTYGEPVEVSVPVHTTGRSQGEVQGGLVDIVVHNLQIVAPGPRRIPQELVVDVTKMNIGDHITAGDIKLPEGCTLAADPELTVVSVLPPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit.
pubmed doi rcsb
molecule tags Ribosome/antibiotic
molecule keywords RIBOSOMAL 23S RNA
total genus 14
structure length 175
sequence length 175
ec nomenclature
pdb deposition date 2010-11-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 3pioS01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 3pioS02
4IO9S 4JXZA 5DM6S 2ZJQS 5JVGS 1EXDA 1FEUA 4WCES 4IOCS 1B75A 2ZJPS 5GAHW 2HZ7A 1EUQA 5JVHS 3PIPS 3CF5S 1QRSA 5GAGW 4WFBS 4IOAS 4WF9S 1GTSA 1QRUA 5IZNA 1NYLA 1QTQA 5GADW 3J7ZV 3PIOS 4JXXA 1D6KA 1EUYA 4P2BA 3AIIA 1QRTA 4UY88 4WFAS 5BNZA 1GTRA 4JYZA 1DFUP 5HL7S 5DM7S 3DLLS 1ZJWA 5GAEW 2RD2A 1O0BA 4U67S 2RE8A 4H3SA 2ZJRS 1O0CA 4WFNS
chains in the Genus database with same CATH superfamily
3GTLC 4AYBD 5DM6S 2JA7C 3GTQC 2A6HA 3M4OC 4WCES 2R7ZC 4KN7A 1Y1VC 2R92C 2NVXC 5C44C 1B75A 1EUQA 2PPBA 2HZ7A 3S1MC 4OIQA 2G6GA 3PIPS 1QRSA 3HOVC 4YFKA 4MEYA 3RZOC 3WODA 1I6VA 4LLGA 4A3BC 4G7OA 2NVQC 5IZNA 2CX8A 3HOWC 3I4NC 2Y0SD 4BY7C 3PO3C 1GTRA 3K7AC 5IYCC 4JYZA 4BY1C 3DLLS 2E2IC 2KXYA 5GAEW 4A3GC 4OINA 3RZDC 2JA6C 3GTKC 5IYDC 1O0CA 4J3CA 5FLMC 2Z0YA 4IO9S 5IYBC 5C3EC 1TWAC 4KN4A 2NVTC 1WCMC 1TWCC 1FEUA 3I4MC 4X6AC 4JK1A 4MEXA 4A3CC 5JVHS 2O5JA 5GAGW 2NVYC 1GTSA 1Y1WC 4A3JC 5C4JC 3S1RC 2PJJA 2G5DA 1QRUA 4LJZA 2PICA 2PA8D 3HOUC 3KW2A 3PIOS 4JXXA 3X1LB 3HOYC 3DXJA 4V194 4L69A 3S17C 1UDXA 2PMZD 4BBSC 1ZJWA 5DM7S 4OIOA 4Y52C 1O0BA 5C4XC 4GZYA 1HQMA 1TWFC 1I50C 3HKZD 2RE8A 4H3SA 2KQ1A 4QJVA 1V6ZA 4MQ9A 5HQHA 4OIPA 2R93C 2GAEA 1TWGC 4A3DC 1I3QC 2WB1D 1ZYRA 3EQLA 5IP9C 2JA8C 4ZH4A 3S2HC 3W2WB 4Y7NC 3M3YC 1VHKA 4IOCS 1IW7A 3S15C 4A3KC 4YFNA 4A3IC 2ZJPS 5TMCA 5TMFA 4Q5SA 2NWAA 4A3FC 1YNNA 4XLNA 4A93C 4NOIA 4WF9S 4G7ZA 2A69A 4YFXA 4G7HA 4XLPA 3PO2C 4LK1A 3S14C 1I6HC 1SFOC 2BE5A 4LK0A 4BBRC 1D6KA 1EUYA 3LYWA 4C3HC 5IP7C 3GTOC 1VHYA 4UY88 4P2BA 1QRTA 2WAQD 5BNZA 4WFAS 2L5NA 4Q4ZA 2L3UA 3HOZC 3S1QC 2PNWA 4C2MC 1Z85A 3H3VD 4C3IC 3S1NC 1TWHC 1QTQA 3CZBA 1K83C 5D4DA 3S2DC 3GTGC 4XSZA 2E2JC 4JXZA 3W2VB 2ZJQS 5JVGS 1SMYA 1BDFA 1EXDA 3GTPC 3H0GC 1R9TC 4H4KA 2EGWA 4A3EC 4A3MC 5GAHW 2A6EA 3CF5S 2A68A 1NXZA 3GTJC 4WFBS 2JA5C 3HOXC 4IOAS 4OIRA 2B63C 4A3LC 2EGVA 2YU9C 1YNJA 2AE0X 4C3JC 1NYLA 2O5IA 5GADW 3J7ZV 2VUMC 4QIWD 4XSXA 4YG2A 3GTMC 4KMUA 3AIIA 2PI8A 3FKIC 2E2HC 4BXXC 4E8BA 1DFUP 5HL7S 3CQZC 2RD2A 2CW0A 4U67S 2KPUA 3S16C 2ZJRS 4WFNS
chains in the Genus database with same CATH topology
4IO9S 4JXZA 3W2VB 5DM6S 2ZJQS 5JVGS 1EXDA 3W2WB 1FEUA 4WCES 4IOCS 4H4KA 1B75A 2ZJPS 5GAHW 2HZ7A 1EUQA 5JVHS 3PIPS 3CF5S 1QRSA 5GAGW 4WFBS 4IOAS 4WF9S 1GTSA 1QRUA 5IZNA 1NYLA 1QTQA 5GADW 3J7ZV 3X1LB 3PIOS 4JXXA 1D6KA 1EUYA 4V194 4P2BA 3AIIA 1QRTA 4UY88 5BNZA 4WFAS 1UDXA 4JYZA 1GTRA 1DFUP 5HL7S 5DM7S 3DLLS 1ZJWA 5GAEW 2RD2A 1O0BA 4U67S 2RE8A 4H3SA 2ZJRS 1O0CA 4WFNS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IO9 S;  4JXZ A;  5DM6 S;  2ZJQ S;  5JVG S;  1EXD A;  1FEU A;  4WCE S;  4IOC S;  1B75 A;  2ZJP S;  5GAH W;  2HZ7 A;  1EUQ A;  5JVH S;  3PIP S;  3CF5 S;  1QRS A;  5GAG W;  4WFB S;  4IOA S;  4WF9 S;  1GTS A;  1QRU A;  5IZN A;  1NYL A;  1QTQ A;  5GAD W;  3J7Z V;  3PIO S;  4JXX A;  1D6K A;  1EUY A;  4P2B A;  3AII A;  1QRT A;  4UY8 8;  4WFA S;  5BNZ A;  1GTR A;  4JYZ A;  1DFU P;  5HL7 S;  5DM7 S;  3DLL S;  1ZJW A;  5GAE W;  2RD2 A;  1O0B A;  4U67 S;  2RE8 A;  4H3S A;  2ZJR S;  1O0C A;  4WFN S; 
#chains in the Genus database with same CATH topology
 3GTL C;  4AYB D;  5DM6 S;  2JA7 C;  3GTQ C;  2A6H A;  3M4O C;  4WCE S;  2R7Z C;  4KN7 A;  1Y1V C;  2R92 C;  2NVX C;  5C44 C;  1B75 A;  1EUQ A;  2PPB A;  2HZ7 A;  3S1M C;  4OIQ A;  2G6G A;  3PIP S;  1QRS A;  3HOV C;  4YFK A;  4MEY A;  3RZO C;  3WOD A;  1I6V A;  4LLG A;  4A3B C;  4G7O A;  2NVQ C;  5IZN A;  2CX8 A;  3HOW C;  3I4N C;  2Y0S D;  4BY7 C;  3PO3 C;  1GTR A;  3K7A C;  5IYC C;  4JYZ A;  4BY1 C;  3DLL S;  2E2I C;  2KXY A;  5GAE W;  4A3G C;  4OIN A;  3RZD C;  2JA6 C;  3GTK C;  5IYD C;  1O0C A;  4J3C A;  5FLM C;  2Z0Y A;  4IO9 S;  5IYB C;  5C3E C;  1TWA C;  4KN4 A;  2NVT C;  1WCM C;  1TWC C;  1FEU A;  3I4M C;  4X6A C;  4JK1 A;  4MEX A;  4A3C C;  5JVH S;  2O5J A;  5GAG W;  2NVY C;  1GTS A;  1Y1W C;  4A3J C;  5C4J C;  3S1R C;  2PJJ A;  2G5D A;  1QRU A;  4LJZ A;  2PIC A;  2PA8 D;  3HOU C;  3KW2 A;  3PIO S;  4JXX A;  3X1L B;  3HOY C;  3DXJ A;  4V19 4;  4L69 A;  3S17 C;  1UDX A;  2PMZ D;  4BBS C;  1ZJW A;  5DM7 S;  4OIO A;  4Y52 C;  1O0B A;  5C4X C;  4GZY A;  1HQM A;  1TWF C;  1I50 C;  3HKZ D;  2RE8 A;  4H3S A;  2KQ1 A;  4QJV A;  1V6Z A;  4MQ9 A;  5HQH A;  4OIP A;  2R93 C;  2GAE A;  1TWG C;  4A3D C;  1I3Q C;  2WB1 D;  1ZYR A;  3EQL A;  5IP9 C;  2JA8 C;  4ZH4 A;  3S2H C;  3W2W B;  4Y7N C;  3M3Y C;  1VHK A;  4IOC S;  1IW7 A;  3S15 C;  4A3K C;  4YFN A;  4A3I C;  2ZJP S;  5TMC A;  5TMF A;  4Q5S A;  2NWA A;  4A3F C;  1YNN A;  4XLN A;  4A93 C;  4NOI A;  4WF9 S;  4G7Z A;  2A69 A;  4YFX A;  4G7H A;  4XLP A;  3PO2 C;  4LK1 A;  3S14 C;  1I6H C;  1SFO C;  2BE5 A;  4LK0 A;  4BBR C;  1D6K A;  1EUY A;  3LYW A;  4C3H C;  5IP7 C;  3GTO C;  1VHY A;  4UY8 8;  4P2B A;  1QRT A;  2WAQ D;  5BNZ A;  4WFA S;  2L5N A;  4Q4Z A;  2L3U A;  3HOZ C;  3S1Q C;  2PNW A;  4C2M C;  1Z85 A;  3H3V D;  4C3I C;  3S1N C;  1TWH C;  1QTQ A;  3CZB A;  1K83 C;  5D4D A;  3S2D C;  3GTG C;  4XSZ A;  2E2J C;  4JXZ A;  3W2V B;  2ZJQ S;  5JVG S;  1SMY A;  1BDF A;  1EXD A;  3GTP C;  3H0G C;  1R9T C;  4H4K A;  2EGW A;  4A3E C;  4A3M C;  5GAH W;  2A6E A;  3CF5 S;  2A68 A;  1NXZ A;  3GTJ C;  4WFB S;  2JA5 C;  3HOX C;  4IOA S;  4OIR A;  2B63 C;  4A3L C;  2EGV A;  2YU9 C;  1YNJ A;  2AE0 X;  4C3J C;  1NYL A;  2O5I A;  5GAD W;  3J7Z V;  2VUM C;  4QIW D;  4XSX A;  4YG2 A;  3GTM C;  4KMU A;  3AII A;  2PI8 A;  3FKI C;  2E2H C;  4BXX C;  4E8B A;  1DFU P;  5HL7 S;  3CQZ C;  2RD2 A;  2CW0 A;  4U67 S;  2KPU A;  3S16 C;  2ZJR S;  4WFN S; 
#chains in the Genus database with same CATH homology
 4IO9 S;  4JXZ A;  3W2V B;  5DM6 S;  2ZJQ S;  5JVG S;  1EXD A;  3W2W B;  1FEU A;  4WCE S;  4IOC S;  4H4K A;  1B75 A;  2ZJP S;  5GAH W;  2HZ7 A;  1EUQ A;  5JVH S;  3PIP S;  3CF5 S;  1QRS A;  5GAG W;  4WFB S;  4IOA S;  4WF9 S;  1GTS A;  1QRU A;  5IZN A;  1NYL A;  1QTQ A;  5GAD W;  3J7Z V;  3X1L B;  3PIO S;  4JXX A;  1D6K A;  1EUY A;  4V19 4;  4P2B A;  3AII A;  1QRT A;  4UY8 8;  5BNZ A;  4WFA S;  1UDX A;  4JYZ A;  1GTR A;  1DFU P;  5HL7 S;  5DM7 S;  3DLL S;  1ZJW A;  5GAE W;  2RD2 A;  1O0B A;  4U67 S;  2RE8 A;  4H3S A;  2ZJR S;  1O0C A;  4WFN S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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