4ADMA

Crystal structure of rv1098c in complex with meso-tartrate
Total Genus 178
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
sequence length
459
structure length
450
Chain Sequence
NYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
molecule tags Lyase
source organism Mycobacterium tuberculosis
molecule keywords FUMARATE HYDRATASE CLASS II
total genus 178
structure length 450
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2011-12-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4admA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4admA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4admA02
2RJSA 1GKJA 3QBPA 1T6JA 1TJ7A 1C3UA 2J91A 1HY1A 1VDKA 2E9FA 1T6PA 1HY0A 3UNVA 3NO9A 3KDZA 1DOFA 1Q5NA 1KQ7A 5HW2A 2O7EA 4C5SA 5EYTA 2QVEA 1Y2MA 4BAAA 1TJUA 1C3CA 3R6YA 1U16A 1RE5A 2VD6A 1AUWA 1JSWA 1YISA 2O7BA 1B8FA 4V2QA 2PTQA 3CZOA 1XWOA 2O7FA 5EYVA 2OHYA 4APBA 2FUSA 4FLCA 3GZHA 1I0AA 1GKMA 1TJVA 3OCEA 1W27A 4APAA 3RRPA 2X75A 1TJWA 2YIIA 1J3UA 1GK3A 3C8TA 2HVGA 4ADLA 2O6YA 3R6VA 4ADMA 4C5UA 4MX2A 4CQ5A 1EB4A 5D6BA 4FFXA 4V2RA 3RD8A 2PTSA 2NYFA 2PFMA 4C5RA 1K62A 5F92A 4NLEA 4NSLA 1FUPA 4C6GA 1K7WA 1FUOA 2QGAB 4BABA 3BHGA 2NYNA 3R6QA 4EFCA 3TV2A 5F91A 3NZ4A 2RJRA 1YFEA 4EEIA 3KDYA 1FUQA 3GTDA 4HGVA 2PTRA 3OCFA 2O7DA 1U15A 1DCNA 3E04A 1FURA 2O78A 1YFMA 1GK2A
chains in the Genus database with same CATH superfamily
1IW7D 2RJSA 1Z4LA 1GKJA 5H8WA 3QBPA 1T6JA 1TJ7A 1XMCA 1C3UA 2J91A 1HY1A 1VDKA 1Z4QA 2E9FA 3U19A 1T6PA 1HY0A 2VSFA 1Z4PX 1Q92A 4MWOA 3UNVA 3NO9A 2JARA 4YIKA 3KDZA 1DOFA 2RCNA 1Q5NA 1U0LA 2D27A 1KQ7A 5HW2A 2O7EA 4C5SA 3CRVA 5EYTA 2QVEA 1Y2MA 4BAAA 1TJUA 2JAOA 1C3CA 3R6YA 1U16A 1RE5A 2VD6A 1AUWA 1JSWA 1YISA 2O7BA 2YV5A 1B8FA 4IQJM 4V2QA 2PTQA 3CZOA 1XWOA 2O7FA 5EYVA 2OHYA 4YIHA 4APBA 2FUSA 4FLCA 1MH9A 3GZHA 3F4TA 1I0AA 2JAUA 3BWVA 1Z4MA 2JAWA 1GKMA 1TJVA 3OCEA 3F4RA 1Z4KA 1Z4JA 1W27A 4APAA 5M0JA 3RRPA 2X75A 1TJWA 2YIIA 2FENA 1XLYA 4L6CA 1J3UA 1GK3A 3C8TA 2HVGA 3U13A 3F4SA 4ADLA 2O6YA 3R6VA 4ADMA 4C5UA 4MX2A 4CQ5A 1EB4A 4E88A 5D6BA 3CRW1 4FFXA 4V2RA 3RD8A 2PTSA 2NYFA 2PFMA 4WNLA 4C5RA 1K62A 2D28C 2I7DA 5F92A 4NLEA 4NSLA 1FUPA 4C6GA 1K7WA 1FUOA 2QGAB 4BABA 3BHGA 2NYNA 4L6AA 2VL7A 3R6QA 3CI0K 4EFCA 3TV2A 5F91A 1XL8A 3NZ4A 2RJRA 1YFEA 4EEIA 3KDYA 1FUQA 3GTDA 1Z4IA 4L57A 5M0IA 4HGVA 2PTRA 3OCFA 2O7DA 1U15A 4NFLA 1DCNA 1XL7A 3E04A 1FURA 1T9HA 1XMDA 4MUMA 2O78A 2FELA 1Q91A 4A15A 1YFMA 1GK2A
chains in the Genus database with same CATH topology
2RJSA 1GKJA 3QBPA 1T6JA 1TJ7A 1C3UA 2J91A 1HY1A 1VDKA 2E9FA 1T6PA 1HY0A 3UNVA 3NO9A 3KDZA 1DOFA 1Q5NA 1KQ7A 5HW2A 2O7EA 4C5SA 5EYTA 2QVEA 1Y2MA 4BAAA 1TJUA 1C3CA 3R6YA 1U16A 1RE5A 2VD6A 1AUWA 1JSWA 1YISA 2O7BA 1B8FA 4V2QA 2PTQA 3CZOA 1XWOA 2O7FA 5EYVA 2OHYA 4APBA 2FUSA 4FLCA 3GZHA 1I0AA 1GKMA 1TJVA 3OCEA 1W27A 4APAA 3RRPA 2X75A 1TJWA 2YIIA 1J3UA 1GK3A 3C8TA 2HVGA 4ADLA 2O6YA 3R6VA 4ADMA 4C5UA 4MX2A 4CQ5A 1EB4A 5D6BA 4FFXA 4V2RA 3RD8A 2PTSA 2NYFA 2PFMA 4C5RA 1K62A 5F92A 4NLEA 4NSLA 1FUPA 4C6GA 1K7WA 1FUOA 2QGAB 4BABA 3BHGA 2NYNA 3R6QA 4EFCA 3TV2A 5F91A 3NZ4A 2RJRA 1YFEA 4EEIA 3KDYA 1FUQA 3GTDA 4HGVA 2PTRA 3OCFA 2O7DA 1U15A 1DCNA 3E04A 1FURA 2O78A 1YFMA 1GK2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2RJS A;  1GKJ A;  3QBP A;  1T6J A;  1TJ7 A;  1C3U A;  2J91 A;  1HY1 A;  1VDK A;  2E9F A;  1T6P A;  1HY0 A;  3UNV A;  3NO9 A;  3KDZ A;  1DOF A;  1Q5N A;  1KQ7 A;  5HW2 A;  2O7E A;  4C5S A;  5EYT A;  2QVE A;  1Y2M A;  4BAA A;  1TJU A;  1C3C A;  3R6Y A;  1U16 A;  1RE5 A;  2VD6 A;  1AUW A;  1JSW A;  1YIS A;  2O7B A;  1B8F A;  4V2Q A;  2PTQ A;  3CZO A;  1XWO A;  2O7F A;  5EYV A;  2OHY A;  4APB A;  2FUS A;  4FLC A;  3GZH A;  1I0A A;  1GKM A;  1TJV A;  3OCE A;  1W27 A;  4APA A;  3RRP A;  2X75 A;  1TJW A;  2YII A;  1J3U A;  1GK3 A;  3C8T A;  2HVG A;  4ADL A;  2O6Y A;  3R6V A;  4ADM A;  4C5U A;  4MX2 A;  4CQ5 A;  1EB4 A;  5D6B A;  4FFX A;  4V2R A;  3RD8 A;  2PTS A;  2NYF A;  2PFM A;  4C5R A;  1K62 A;  5F92 A;  4NLE A;  4NSL A;  1FUP A;  4C6G A;  1K7W A;  1FUO A;  2QGA B;  4BAB A;  3BHG A;  2NYN A;  3R6Q A;  4EFC A;  3TV2 A;  5F91 A;  3NZ4 A;  2RJR A;  1YFE A;  4EEI A;  3KDY A;  1FUQ A;  3GTD A;  4HGV A;  2PTR A;  3OCF A;  2O7D A;  1U15 A;  1DCN A;  3E04 A;  1FUR A;  2O78 A;  1YFM A;  1GK2 A; 
#chains in the Genus database with same CATH topology
 1IW7 D;  2RJS A;  1Z4L A;  1GKJ A;  5H8W A;  3QBP A;  1T6J A;  1TJ7 A;  1XMC A;  1C3U A;  2J91 A;  1HY1 A;  1VDK A;  1Z4Q A;  2E9F A;  3U19 A;  1T6P A;  1HY0 A;  2VSF A;  1Z4P X;  1Q92 A;  4MWO A;  3UNV A;  3NO9 A;  2JAR A;  4YIK A;  3KDZ A;  1DOF A;  2RCN A;  1Q5N A;  1U0L A;  2D27 A;  1KQ7 A;  5HW2 A;  2O7E A;  4C5S A;  3CRV A;  5EYT A;  2QVE A;  1Y2M A;  4BAA A;  1TJU A;  2JAO A;  1C3C A;  3R6Y A;  1U16 A;  1RE5 A;  2VD6 A;  1AUW A;  1JSW A;  1YIS A;  2O7B A;  2YV5 A;  1B8F A;  4IQJ M;  4V2Q A;  2PTQ A;  3CZO A;  1XWO A;  2O7F A;  5EYV A;  2OHY A;  4YIH A;  4APB A;  2FUS A;  4FLC A;  1MH9 A;  3GZH A;  3F4T A;  1I0A A;  2JAU A;  3BWV A;  1Z4M A;  2JAW A;  1GKM A;  1TJV A;  3OCE A;  3F4R A;  1Z4K A;  1Z4J A;  1W27 A;  4APA A;  5M0J A;  3RRP A;  2X75 A;  1TJW A;  2YII A;  2FEN A;  1XLY A;  4L6C A;  1J3U A;  1GK3 A;  3C8T A;  2HVG A;  3U13 A;  3F4S A;  4ADL A;  2O6Y A;  3R6V A;  4ADM A;  4C5U A;  4MX2 A;  4CQ5 A;  1EB4 A;  4E88 A;  5D6B A;  3CRW 1;  4FFX A;  4V2R A;  3RD8 A;  2PTS A;  2NYF A;  2PFM A;  4WNL A;  4C5R A;  1K62 A;  2D28 C;  2I7D A;  5F92 A;  4NLE A;  4NSL A;  1FUP A;  4C6G A;  1K7W A;  1FUO A;  2QGA B;  4BAB A;  3BHG A;  2NYN A;  4L6A A;  2VL7 A;  3R6Q A;  3CI0 K;  4EFC A;  3TV2 A;  5F91 A;  1XL8 A;  3NZ4 A;  2RJR A;  1YFE A;  4EEI A;  3KDY A;  1FUQ A;  3GTD A;  1Z4I A;  4L57 A;  5M0I A;  4HGV A;  2PTR A;  3OCF A;  2O7D A;  1U15 A;  4NFL A;  1DCN A;  1XL7 A;  3E04 A;  1FUR A;  1T9H A;  1XMD A;  4MUM A;  2O78 A;  2FEL A;  1Q91 A;  4A15 A;  1YFM A;  1GK2 A; 
#chains in the Genus database with same CATH homology
 2RJS A;  1GKJ A;  3QBP A;  1T6J A;  1TJ7 A;  1C3U A;  2J91 A;  1HY1 A;  1VDK A;  2E9F A;  1T6P A;  1HY0 A;  3UNV A;  3NO9 A;  3KDZ A;  1DOF A;  1Q5N A;  1KQ7 A;  5HW2 A;  2O7E A;  4C5S A;  5EYT A;  2QVE A;  1Y2M A;  4BAA A;  1TJU A;  1C3C A;  3R6Y A;  1U16 A;  1RE5 A;  2VD6 A;  1AUW A;  1JSW A;  1YIS A;  2O7B A;  1B8F A;  4V2Q A;  2PTQ A;  3CZO A;  1XWO A;  2O7F A;  5EYV A;  2OHY A;  4APB A;  2FUS A;  4FLC A;  3GZH A;  1I0A A;  1GKM A;  1TJV A;  3OCE A;  1W27 A;  4APA A;  3RRP A;  2X75 A;  1TJW A;  2YII A;  1J3U A;  1GK3 A;  3C8T A;  2HVG A;  4ADL A;  2O6Y A;  3R6V A;  4ADM A;  4C5U A;  4MX2 A;  4CQ5 A;  1EB4 A;  5D6B A;  4FFX A;  4V2R A;  3RD8 A;  2PTS A;  2NYF A;  2PFM A;  4C5R A;  1K62 A;  5F92 A;  4NLE A;  4NSL A;  1FUP A;  4C6G A;  1K7W A;  1FUO A;  2QGA B;  4BAB A;  3BHG A;  2NYN A;  3R6Q A;  4EFC A;  3TV2 A;  5F91 A;  3NZ4 A;  2RJR A;  1YFE A;  4EEI A;  3KDY A;  1FUQ A;  3GTD A;  4HGV A;  2PTR A;  3OCF A;  2O7D A;  1U15 A;  1DCN A;  3E04 A;  1FUR A;  2O78 A;  1YFM A;  1GK2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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