4ADMA

Crystal structure of rv1098c in complex with meso-tartrate
Total Genus 178
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
sequence length
459
structure length
450
Chain Sequence
NYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
molecule tags Lyase
source organism Mycobacterium tuberculosis
molecule keywords FUMARATE HYDRATASE CLASS II
total genus 178
structure length 450
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2011-12-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4admA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4admA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4admA02
3CZOA 5EYVA 1J3UA 1GKJA 1Y2MA 4V2RA 1RE5A 3NO9A 1GK3A 2J91A 2O7FA 3TV2A 5F92A 4FLCA 2O78A 2NYNA 3RD8A 5D6BA 3GZHA 4HGVA 3GTDA 4FFXA 2X75A 1YFMA 1Q5NA 3OCFA 1HY0A 4EEIA 5HW2A 1T6PA 2PFMA 4MX2A 4BABA 1FURA 3QBPA 1YFEA 1B8FA 3R6QA 4ADMA 3NZ4A 2RJSA 2E9FA 1W27A 1U16A 3RRPA 4APAA 1YISA 1K7WA 1TJWA 3R6VA 5F91A 4C5RA 2O7EA 2OHYA 1K62A 2O6YA 3E04A 1JSWA 4V2QA 4C6GA 1TJ7A 4APBA 1XWOA 4CQ5A 5EYTA 4C5UA 4C5SA 1KQ7A 2YIIA 2PTQA 1GK2A 3C8TA 2O7BA 4NSLA 1GKMA 3R6YA 4BAAA 1DOFA 1FUOA 2FUSA 2HVGA 1I0AA 1VDKA 2QGAB 1FUPA 1C3CA 2QVEA 3OCEA 3KDYA 3BHGA 1TJVA 4NLEA 3UNVA 2VD6A 2NYFA 1DCNA 1TJUA 4EFCA 4ADLA 1AUWA 2O7DA 3KDZA 2PTRA 1EB4A 1C3UA 1HY1A 1U15A 1T6JA 1FUQA 2RJRA 2PTSA
chains in the Genus database with same CATH superfamily
3CZOA 5EYVA 4WNLA 2RCNA 1J3UA 3U19A 2FELA 5M0IA 1GKJA 1Y2MA 4V2RA 1RE5A 3NO9A 3CI0K 1GK3A 2FENA 1IW7D 1Q91A 2J91A 4L6CA 2O7FA 1XL8A 1U0LA 3TV2A 5F92A 4YIHA 1XMDA 4FLCA 2O78A 2NYNA 3RD8A 4NFLA 5D6BA 3F4RA 3GZHA 4HGVA 2D27A 3GTDA 4FFXA 1T9HA 1YFMA 2X75A 1Q5NA 4MWOA 3OCFA 1HY0A 4EEIA 5HW2A 1T6PA 2PFMA 4IQJM 4MX2A 4BABA 1FURA 3QBPA 1XL7A 1YFEA 1Z4PX 2JAOA 1B8FA 1XLYA 3R6QA 2JAUA 4ADMA 1Z4LA 2VL7A 2RJSA 3NZ4A 2E9FA 1W27A 1U16A 3RRPA 2VSFA 4APAA 1YISA 1K7WA 1TJWA 3R6VA 4MUMA 5F91A 4C5RA 2O7EA 2OHYA 1K62A 2O6YA 3E04A 1JSWA 4V2QA 4C6GA 1Z4JA 1Z4IA 4A15A 1TJ7A 4APBA 1XWOA 4CQ5A 4L6AA 5EYTA 3BWVA 4C5UA 1MH9A 1KQ7A 4C5SA 2YIIA 1Q92A 4YIKA 2PTQA 4E88A 1GK2A 5H8WA 3C8TA 2YV5A 2O7BA 3CRW1 4NSLA 1GKMA 3CRVA 3R6YA 4BAAA 1DOFA 1FUOA 2FUSA 1Z4MA 2HVGA 1I0AA 1VDKA 2QGAB 1FUPA 1C3CA 2QVEA 2JARA 3OCEA 3KDYA 3BHGA 1TJVA 4NLEA 3UNVA 2VD6A 3F4SA 2NYFA 1XMCA 1DCNA 2D28C 1TJUA 4L57A 4EFCA 4ADLA 1AUWA 2JAWA 2O7DA 3KDZA 2PTRA 1EB4A 1C3UA 1HY1A 1U15A 3F4TA 1FUQA 1T6JA 2RJRA 1Z4QA 5M0JA 1Z4KA 2I7DA 2PTSA 3U13A
chains in the Genus database with same CATH topology
3CZOA 5EYVA 1J3UA 1GKJA 1Y2MA 4V2RA 1RE5A 3NO9A 1GK3A 2J91A 2O7FA 3TV2A 5F92A 4FLCA 2O78A 2NYNA 3RD8A 5D6BA 3GZHA 4HGVA 3GTDA 4FFXA 2X75A 1YFMA 1Q5NA 3OCFA 1HY0A 4EEIA 5HW2A 1T6PA 2PFMA 4MX2A 4BABA 1FURA 3QBPA 1YFEA 1B8FA 3R6QA 4ADMA 3NZ4A 2RJSA 2E9FA 1W27A 1U16A 3RRPA 4APAA 1YISA 1K7WA 1TJWA 3R6VA 5F91A 4C5RA 2O7EA 2OHYA 1K62A 2O6YA 3E04A 1JSWA 4V2QA 4C6GA 1TJ7A 4APBA 1XWOA 4CQ5A 5EYTA 4C5UA 4C5SA 1KQ7A 2YIIA 2PTQA 1GK2A 3C8TA 2O7BA 4NSLA 1GKMA 3R6YA 4BAAA 1DOFA 1FUOA 2FUSA 2HVGA 1I0AA 1VDKA 2QGAB 1FUPA 1C3CA 2QVEA 3OCEA 3KDYA 3BHGA 1TJVA 4NLEA 3UNVA 2VD6A 2NYFA 1DCNA 1TJUA 4EFCA 4ADLA 1AUWA 2O7DA 3KDZA 2PTRA 1EB4A 1C3UA 1HY1A 1U15A 1T6JA 1FUQA 2RJRA 2PTSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CZO A;  5EYV A;  1J3U A;  1GKJ A;  1Y2M A;  4V2R A;  1RE5 A;  3NO9 A;  1GK3 A;  2J91 A;  2O7F A;  3TV2 A;  5F92 A;  4FLC A;  2O78 A;  2NYN A;  3RD8 A;  5D6B A;  3GZH A;  4HGV A;  3GTD A;  4FFX A;  2X75 A;  1YFM A;  1Q5N A;  3OCF A;  1HY0 A;  4EEI A;  5HW2 A;  1T6P A;  2PFM A;  4MX2 A;  4BAB A;  1FUR A;  3QBP A;  1YFE A;  1B8F A;  3R6Q A;  4ADM A;  3NZ4 A;  2RJS A;  2E9F A;  1W27 A;  1U16 A;  3RRP A;  4APA A;  1YIS A;  1K7W A;  1TJW A;  3R6V A;  5F91 A;  4C5R A;  2O7E A;  2OHY A;  1K62 A;  2O6Y A;  3E04 A;  1JSW A;  4V2Q A;  4C6G A;  1TJ7 A;  4APB A;  1XWO A;  4CQ5 A;  5EYT A;  4C5U A;  4C5S A;  1KQ7 A;  2YII A;  2PTQ A;  1GK2 A;  3C8T A;  2O7B A;  4NSL A;  1GKM A;  3R6Y A;  4BAA A;  1DOF A;  1FUO A;  2FUS A;  2HVG A;  1I0A A;  1VDK A;  2QGA B;  1FUP A;  1C3C A;  2QVE A;  3OCE A;  3KDY A;  3BHG A;  1TJV A;  4NLE A;  3UNV A;  2VD6 A;  2NYF A;  1DCN A;  1TJU A;  4EFC A;  4ADL A;  1AUW A;  2O7D A;  3KDZ A;  2PTR A;  1EB4 A;  1C3U A;  1HY1 A;  1U15 A;  1T6J A;  1FUQ A;  2RJR A;  2PTS A; 
#chains in the Genus database with same CATH topology
 3CZO A;  5EYV A;  4WNL A;  2RCN A;  1J3U A;  3U19 A;  2FEL A;  5M0I A;  1GKJ A;  1Y2M A;  4V2R A;  1RE5 A;  3NO9 A;  3CI0 K;  1GK3 A;  2FEN A;  1IW7 D;  1Q91 A;  2J91 A;  4L6C A;  2O7F A;  1XL8 A;  1U0L A;  3TV2 A;  5F92 A;  4YIH A;  1XMD A;  4FLC A;  2O78 A;  2NYN A;  3RD8 A;  4NFL A;  5D6B A;  3F4R A;  3GZH A;  4HGV A;  2D27 A;  3GTD A;  4FFX A;  1T9H A;  1YFM A;  2X75 A;  1Q5N A;  4MWO A;  3OCF A;  1HY0 A;  4EEI A;  5HW2 A;  1T6P A;  2PFM A;  4IQJ M;  4MX2 A;  4BAB A;  1FUR A;  3QBP A;  1XL7 A;  1YFE A;  1Z4P X;  2JAO A;  1B8F A;  1XLY A;  3R6Q A;  2JAU A;  4ADM A;  1Z4L A;  2VL7 A;  2RJS A;  3NZ4 A;  2E9F A;  1W27 A;  1U16 A;  3RRP A;  2VSF A;  4APA A;  1YIS A;  1K7W A;  1TJW A;  3R6V A;  4MUM A;  5F91 A;  4C5R A;  2O7E A;  2OHY A;  1K62 A;  2O6Y A;  3E04 A;  1JSW A;  4V2Q A;  4C6G A;  1Z4J A;  1Z4I A;  4A15 A;  1TJ7 A;  4APB A;  1XWO A;  4CQ5 A;  4L6A A;  5EYT A;  3BWV A;  4C5U A;  1MH9 A;  1KQ7 A;  4C5S A;  2YII A;  1Q92 A;  4YIK A;  2PTQ A;  4E88 A;  1GK2 A;  5H8W A;  3C8T A;  2YV5 A;  2O7B A;  3CRW 1;  4NSL A;  1GKM A;  3CRV A;  3R6Y A;  4BAA A;  1DOF A;  1FUO A;  2FUS A;  1Z4M A;  2HVG A;  1I0A A;  1VDK A;  2QGA B;  1FUP A;  1C3C A;  2QVE A;  2JAR A;  3OCE A;  3KDY A;  3BHG A;  1TJV A;  4NLE A;  3UNV A;  2VD6 A;  3F4S A;  2NYF A;  1XMC A;  1DCN A;  2D28 C;  1TJU A;  4L57 A;  4EFC A;  4ADL A;  1AUW A;  2JAW A;  2O7D A;  3KDZ A;  2PTR A;  1EB4 A;  1C3U A;  1HY1 A;  1U15 A;  3F4T A;  1FUQ A;  1T6J A;  2RJR A;  1Z4Q A;  5M0J A;  1Z4K A;  2I7D A;  2PTS A;  3U13 A; 
#chains in the Genus database with same CATH homology
 3CZO A;  5EYV A;  1J3U A;  1GKJ A;  1Y2M A;  4V2R A;  1RE5 A;  3NO9 A;  1GK3 A;  2J91 A;  2O7F A;  3TV2 A;  5F92 A;  4FLC A;  2O78 A;  2NYN A;  3RD8 A;  5D6B A;  3GZH A;  4HGV A;  3GTD A;  4FFX A;  2X75 A;  1YFM A;  1Q5N A;  3OCF A;  1HY0 A;  4EEI A;  5HW2 A;  1T6P A;  2PFM A;  4MX2 A;  4BAB A;  1FUR A;  3QBP A;  1YFE A;  1B8F A;  3R6Q A;  4ADM A;  3NZ4 A;  2RJS A;  2E9F A;  1W27 A;  1U16 A;  3RRP A;  4APA A;  1YIS A;  1K7W A;  1TJW A;  3R6V A;  5F91 A;  4C5R A;  2O7E A;  2OHY A;  1K62 A;  2O6Y A;  3E04 A;  1JSW A;  4V2Q A;  4C6G A;  1TJ7 A;  4APB A;  1XWO A;  4CQ5 A;  5EYT A;  4C5U A;  4C5S A;  1KQ7 A;  2YII A;  2PTQ A;  1GK2 A;  3C8T A;  2O7B A;  4NSL A;  1GKM A;  3R6Y A;  4BAA A;  1DOF A;  1FUO A;  2FUS A;  2HVG A;  1I0A A;  1VDK A;  2QGA B;  1FUP A;  1C3C A;  2QVE A;  3OCE A;  3KDY A;  3BHG A;  1TJV A;  4NLE A;  3UNV A;  2VD6 A;  2NYF A;  1DCN A;  1TJU A;  4EFC A;  4ADL A;  1AUW A;  2O7D A;  3KDZ A;  2PTR A;  1EB4 A;  1C3U A;  1HY1 A;  1U15 A;  1T6J A;  1FUQ A;  2RJR A;  2PTS A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...