4ADMA

Crystal structure of rv1098c in complex with meso-tartrate
Total Genus 178
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
sequence length
459
structure length
450
Chain Sequence
NYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
molecule tags Lyase
source organism Mycobacterium tuberculosis
molecule keywords FUMARATE HYDRATASE CLASS II
total genus 178
structure length 450
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2011-12-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4admA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4admA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4admA02
1RE5A 1GKJA 4EFCA 1K7WA 1B8FA 2X75A 2QGAB 2O6YA 3UNVA 1U15A 1GK3A 1GKMA 3NO9A 2PTRA 2HVGA 1XWOA 2VD6A 5EYTA 1T6JA 3KDYA 1HY1A 2RJRA 3C8TA 4BABA 2O7DA 4ADMA 2OHYA 1FUOA 4C6GA 1U16A 2YIIA 3OCFA 3R6YA 1Q5NA 4NSLA 5F92A 1I0AA 3GZHA 1C3UA 1C3CA 2FUSA 4APBA 3NZ4A 1DOFA 2E9FA 1TJWA 5F91A 2PTQA 1YFMA 4BAAA 3RRPA 1YFEA 1YISA 3OCEA 3TV2A 1TJUA 2PFMA 4EEIA 1FURA 1K62A 2NYFA 1KQ7A 2O7EA 4FLCA 1GK2A 4ADLA 1HY0A 1VDKA 4FFXA 1AUWA 4V2RA 3QBPA 1FUPA 4APAA 1TJ7A 3BHGA 3GTDA 5D6BA 1TJVA 1EB4A 1T6PA 4NLEA 1W27A 1Y2MA 1JSWA 4CQ5A 3R6QA 4V2QA 5HW2A 2NYNA 4MX2A 3KDZA 4C5RA 2O7FA 1J3UA 4C5UA 2PTSA 2J91A 3RD8A 4C5SA 2O7BA 3R6VA 5EYVA 2RJSA 1DCNA 1FUQA 2QVEA 4HGVA 2O78A 3CZOA 3E04A
chains in the Genus database with same CATH superfamily
1RE5A 1Z4QA 1GKJA 4EFCA 1K7WA 4L57A 1B8FA 2X75A 4IQJM 2QGAB 1XL7A 2O6YA 5M0IA 3UNVA 1U15A 1GK3A 1GKMA 3F4SA 4WNLA 3NO9A 2PTRA 2HVGA 1XWOA 3CRW1 2VD6A 3U19A 3F4RA 3BWVA 5EYTA 4E88A 1T6JA 3KDYA 1HY1A 2RJRA 3C8TA 4BABA 2O7DA 4ADMA 2RCNA 4MUMA 4L6AA 2OHYA 1FUOA 4C6GA 1MH9A 4YIHA 5H8WA 1U16A 2YIIA 3OCFA 3R6YA 1Q5NA 2FENA 2FELA 4NSLA 5F92A 2JARA 1I0AA 1Z4LA 3F4TA 3GZHA 4MWOA 1C3UA 1C3CA 2FUSA 4APBA 1XMDA 3NZ4A 1DOFA 2E9FA 1TJWA 5F91A 2PTQA 1XLYA 1YFMA 4BAAA 1Q92A 3RRPA 1YFEA 1YISA 3OCEA 3TV2A 4YIKA 1TJUA 2PFMA 4EEIA 1FURA 1K62A 2NYFA 1XMCA 1KQ7A 4L6CA 1Z4KA 2O7EA 4FLCA 1IW7D 1GK2A 4ADLA 2D28C 1HY0A 2I7DA 1VDKA 2JAUA 4FFXA 1AUWA 1Q91A 2JAOA 4V2RA 3QBPA 1FUPA 2JAWA 4APAA 1TJ7A 3BHGA 3GTDA 5D6BA 3CRVA 1TJVA 1EB4A 1T6PA 4NLEA 2YV5A 1Z4IA 1W27A 1Y2MA 5M0JA 1JSWA 4CQ5A 3U13A 1T9HA 1Z4MA 3R6QA 4V2QA 5HW2A 2NYNA 4MX2A 3KDZA 4C5RA 2O7FA 1J3UA 4C5UA 2PTSA 2VL7A 2D27A 2J91A 1Z4PX 3RD8A 1XL8A 2O7BA 3R6VA 5EYVA 4C5SA 1Z4JA 3CI0K 2RJSA 1DCNA 1FUQA 2QVEA 1U0LA 4HGVA 4A15A 2O78A 4NFLA 3CZOA 2VSFA 3E04A
chains in the Genus database with same CATH topology
1RE5A 1GKJA 4EFCA 1K7WA 1B8FA 2X75A 2QGAB 2O6YA 3UNVA 1U15A 1GK3A 1GKMA 3NO9A 2PTRA 2HVGA 1XWOA 2VD6A 5EYTA 1T6JA 3KDYA 1HY1A 2RJRA 3C8TA 4BABA 2O7DA 4ADMA 2OHYA 1FUOA 4C6GA 1U16A 2YIIA 3OCFA 3R6YA 1Q5NA 4NSLA 5F92A 1I0AA 3GZHA 1C3UA 1C3CA 2FUSA 4APBA 3NZ4A 1DOFA 2E9FA 1TJWA 5F91A 2PTQA 1YFMA 4BAAA 3RRPA 1YFEA 1YISA 3OCEA 3TV2A 1TJUA 2PFMA 4EEIA 1FURA 1K62A 2NYFA 1KQ7A 2O7EA 4FLCA 1GK2A 4ADLA 1HY0A 1VDKA 4FFXA 1AUWA 4V2RA 3QBPA 1FUPA 4APAA 1TJ7A 3BHGA 3GTDA 5D6BA 1TJVA 1EB4A 1T6PA 4NLEA 1W27A 1Y2MA 1JSWA 4CQ5A 3R6QA 4V2QA 5HW2A 2NYNA 4MX2A 3KDZA 4C5RA 2O7FA 1J3UA 4C5UA 2PTSA 2J91A 3RD8A 4C5SA 2O7BA 3R6VA 5EYVA 2RJSA 1DCNA 1FUQA 2QVEA 4HGVA 2O78A 3CZOA 3E04A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RE5 A;  1GKJ A;  4EFC A;  1K7W A;  1B8F A;  2X75 A;  2QGA B;  2O6Y A;  3UNV A;  1U15 A;  1GK3 A;  1GKM A;  3NO9 A;  2PTR A;  2HVG A;  1XWO A;  2VD6 A;  5EYT A;  1T6J A;  3KDY A;  1HY1 A;  2RJR A;  3C8T A;  4BAB A;  2O7D A;  4ADM A;  2OHY A;  1FUO A;  4C6G A;  1U16 A;  2YII A;  3OCF A;  3R6Y A;  1Q5N A;  4NSL A;  5F92 A;  1I0A A;  3GZH A;  1C3U A;  1C3C A;  2FUS A;  4APB A;  3NZ4 A;  1DOF A;  2E9F A;  1TJW A;  5F91 A;  2PTQ A;  1YFM A;  4BAA A;  3RRP A;  1YFE A;  1YIS A;  3OCE A;  3TV2 A;  1TJU A;  2PFM A;  4EEI A;  1FUR A;  1K62 A;  2NYF A;  1KQ7 A;  2O7E A;  4FLC A;  1GK2 A;  4ADL A;  1HY0 A;  1VDK A;  4FFX A;  1AUW A;  4V2R A;  3QBP A;  1FUP A;  4APA A;  1TJ7 A;  3BHG A;  3GTD A;  5D6B A;  1TJV A;  1EB4 A;  1T6P A;  4NLE A;  1W27 A;  1Y2M A;  1JSW A;  4CQ5 A;  3R6Q A;  4V2Q A;  5HW2 A;  2NYN A;  4MX2 A;  3KDZ A;  4C5R A;  2O7F A;  1J3U A;  4C5U A;  2PTS A;  2J91 A;  3RD8 A;  4C5S A;  2O7B A;  3R6V A;  5EYV A;  2RJS A;  1DCN A;  1FUQ A;  2QVE A;  4HGV A;  2O78 A;  3CZO A;  3E04 A; 
#chains in the Genus database with same CATH topology
 1RE5 A;  1Z4Q A;  1GKJ A;  4EFC A;  1K7W A;  4L57 A;  1B8F A;  2X75 A;  4IQJ M;  2QGA B;  1XL7 A;  2O6Y A;  5M0I A;  3UNV A;  1U15 A;  1GK3 A;  1GKM A;  3F4S A;  4WNL A;  3NO9 A;  2PTR A;  2HVG A;  1XWO A;  3CRW 1;  2VD6 A;  3U19 A;  3F4R A;  3BWV A;  5EYT A;  4E88 A;  1T6J A;  3KDY A;  1HY1 A;  2RJR A;  3C8T A;  4BAB A;  2O7D A;  4ADM A;  2RCN A;  4MUM A;  4L6A A;  2OHY A;  1FUO A;  4C6G A;  1MH9 A;  4YIH A;  5H8W A;  1U16 A;  2YII A;  3OCF A;  3R6Y A;  1Q5N A;  2FEN A;  2FEL A;  4NSL A;  5F92 A;  2JAR A;  1I0A A;  1Z4L A;  3F4T A;  3GZH A;  4MWO A;  1C3U A;  1C3C A;  2FUS A;  4APB A;  1XMD A;  3NZ4 A;  1DOF A;  2E9F A;  1TJW A;  5F91 A;  2PTQ A;  1XLY A;  1YFM A;  4BAA A;  1Q92 A;  3RRP A;  1YFE A;  1YIS A;  3OCE A;  3TV2 A;  4YIK A;  1TJU A;  2PFM A;  4EEI A;  1FUR A;  1K62 A;  2NYF A;  1XMC A;  1KQ7 A;  4L6C A;  1Z4K A;  2O7E A;  4FLC A;  1IW7 D;  1GK2 A;  4ADL A;  2D28 C;  1HY0 A;  2I7D A;  1VDK A;  2JAU A;  4FFX A;  1AUW A;  1Q91 A;  2JAO A;  4V2R A;  3QBP A;  1FUP A;  2JAW A;  4APA A;  1TJ7 A;  3BHG A;  3GTD A;  5D6B A;  3CRV A;  1TJV A;  1EB4 A;  1T6P A;  4NLE A;  2YV5 A;  1Z4I A;  1W27 A;  1Y2M A;  5M0J A;  1JSW A;  4CQ5 A;  3U13 A;  1T9H A;  1Z4M A;  3R6Q A;  4V2Q A;  5HW2 A;  2NYN A;  4MX2 A;  3KDZ A;  4C5R A;  2O7F A;  1J3U A;  4C5U A;  2PTS A;  2VL7 A;  2D27 A;  2J91 A;  1Z4P X;  3RD8 A;  1XL8 A;  2O7B A;  3R6V A;  5EYV A;  4C5S A;  1Z4J A;  3CI0 K;  2RJS A;  1DCN A;  1FUQ A;  2QVE A;  1U0L A;  4HGV A;  4A15 A;  2O78 A;  4NFL A;  3CZO A;  2VSF A;  3E04 A; 
#chains in the Genus database with same CATH homology
 1RE5 A;  1GKJ A;  4EFC A;  1K7W A;  1B8F A;  2X75 A;  2QGA B;  2O6Y A;  3UNV A;  1U15 A;  1GK3 A;  1GKM A;  3NO9 A;  2PTR A;  2HVG A;  1XWO A;  2VD6 A;  5EYT A;  1T6J A;  3KDY A;  1HY1 A;  2RJR A;  3C8T A;  4BAB A;  2O7D A;  4ADM A;  2OHY A;  1FUO A;  4C6G A;  1U16 A;  2YII A;  3OCF A;  3R6Y A;  1Q5N A;  4NSL A;  5F92 A;  1I0A A;  3GZH A;  1C3U A;  1C3C A;  2FUS A;  4APB A;  3NZ4 A;  1DOF A;  2E9F A;  1TJW A;  5F91 A;  2PTQ A;  1YFM A;  4BAA A;  3RRP A;  1YFE A;  1YIS A;  3OCE A;  3TV2 A;  1TJU A;  2PFM A;  4EEI A;  1FUR A;  1K62 A;  2NYF A;  1KQ7 A;  2O7E A;  4FLC A;  1GK2 A;  4ADL A;  1HY0 A;  1VDK A;  4FFX A;  1AUW A;  4V2R A;  3QBP A;  1FUP A;  4APA A;  1TJ7 A;  3BHG A;  3GTD A;  5D6B A;  1TJV A;  1EB4 A;  1T6P A;  4NLE A;  1W27 A;  1Y2M A;  1JSW A;  4CQ5 A;  3R6Q A;  4V2Q A;  5HW2 A;  2NYN A;  4MX2 A;  3KDZ A;  4C5R A;  2O7F A;  1J3U A;  4C5U A;  2PTS A;  2J91 A;  3RD8 A;  4C5S A;  2O7B A;  3R6V A;  5EYV A;  2RJS A;  1DCN A;  1FUQ A;  2QVE A;  4HGV A;  2O78 A;  3CZO A;  3E04 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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