4HGVA

Crystal structure of a fumarate hydratase
Total Genus 158
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
sequence length
461
structure length
456
Chain Sequence
STRTETDTFGPIEVASDRYWGAQAQRSLGNFKIGWEKQPLAIVRALGIVKQAAARANMALGRLDPAIGDAIVKAAQEVIDGKLDEHFPLVVWQTGSGTQSNMNANEVVSNRAIELLGGVMGSKKPVHPNDHVNMSQSSNDTYPTAMHIACAERVIHDLLPALKHLHKALEEKVKAFDHIIKIGRTHTQDATPLTLGQEFSGYAAQVASSIKRIEMTLPGLCELAQGGTAVGTGLNAPVGFAEKVAEEIAAITGIGFTSAPNKFEALAAHDSMVFSHGAINATAAALFKIANDIRFLGSGPRSGLGELSLPENEPGSKVNPTQCEALTQVCVQVFGNHAALTFAGSQGHFELNVYNPLMAYNFLQSVQLLADAAISFTDNCVVGIEAREDNIKAALDRSLMLVTALAPKIGYDNAAKIAKTAHKNGTTLREEAVGGGYVTDEEFDAVVRPETMIGPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Lyase
source organism Sinorhizobium meliloti
publication title Crystal structure of a fumarate hydratase
rcsb
molecule keywords Fumarate hydratase class II
total genus 158
structure length 456
sequence length 461
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2012-10-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4hgvA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4hgvA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4hgvA02
1TJUA 2RJRA 4FLCA 1FUQA 2OHYA 1YFMA 5D6BA 5HW2A 4C5SA 3NO9A 2PFMA 3C8TA 1YFEA 2O7BA 2RJSA 4CQ5A 1C3CA 4C6GA 1FURA 3RRPA 4EFCA 5EYVA 1DCNA 3UNVA 5F91A 1J3UA 3NZ4A 2FUSA 2O7DA 2O6YA 4FFXA 3R6QA 3KDZA 2YIIA 1GKJA 2J91A 1U15A 4APBA 3GZHA 1TJ7A 2NYNA 4EEIA 3R6VA 1K62A 3BHGA 1T6PA 1AUWA 4C5UA 1FUOA 1HY0A 2X75A 4APAA 4C5RA 1TJVA 1XWOA 2VD6A 1I0AA 3KDYA 4BABA 1GK3A 3RD8A 3OCEA 4ADMA 1FUPA 4HGVA 1GK2A 4ADLA 3OCFA 1Q5NA 1DOFA 2NYFA 3GTDA 4BAAA 1YISA 1JSWA 1HY1A 3CZOA 3R6YA 1KQ7A 1W27A 1TJWA 1EB4A 1RE5A 1GKMA 2O78A 2HVGA 4NLEA 2QGAB 3E04A 5EYTA 2O7EA 4V2RA 2PTRA 3QBPA 1K7WA 3TV2A 1T6JA 1VDKA 4V2QA 5F92A 2QVEA 4MX2A 1U16A 2PTSA 1B8FA 2E9FA 4NSLA 2PTQA 1Y2MA 1C3UA 2O7FA
chains in the Genus database with same CATH superfamily
5M0JA 1TJUA 4NFLA 2RJRA 1Z4MA 1Z4JA 4FLCA 1FUQA 4L6AA 2OHYA 1YFMA 2RCNA 5D6BA 3U13A 5HW2A 4C5SA 3NO9A 2PFMA 2I7DA 1MH9A 3C8TA 1YFEA 2O7BA 5M0IA 2RJSA 4CQ5A 1C3CA 4C6GA 1FURA 3RRPA 4EFCA 5EYVA 1DCNA 3UNVA 1Z4KA 1Z4IA 5F91A 4L6CA 1J3UA 3NZ4A 2FUSA 2O7DA 2O6YA 4FFXA 5H8WA 3R6QA 3KDZA 3F4RA 1Z4QA 2YIIA 1GKJA 2J91A 1U15A 4APBA 3GZHA 1TJ7A 2NYNA 4EEIA 3R6VA 2D27A 4A15A 1K62A 3BHGA 1T6PA 1AUWA 4C5UA 1FUOA 4MWOA 2FELA 1HY0A 2X75A 3U19A 4APAA 3CRVA 3CRW1 4C5RA 3CI0K 1Z4LA 2FENA 1TJVA 1Z4PX 4YIKA 2JAOA 1U0LA 1XWOA 2VD6A 2VL7A 1I0AA 1Q91A 4L57A 3KDYA 4BABA 1XL8A 4WNLA 1GK3A 3BWVA 3RD8A 3OCEA 4ADMA 1FUPA 4HGVA 4ADLA 1GK2A 3OCFA 1DOFA 1Q5NA 1Q92A 2NYFA 3GTDA 4BAAA 1XL7A 3F4SA 2D28C 1YISA 1JSWA 1HY1A 3CZOA 3R6YA 1KQ7A 1T9HA 2JAWA 1W27A 1TJWA 1EB4A 4MUMA 1RE5A 2VSFA 1GKMA 2O78A 1XLYA 1IW7D 2HVGA 2JARA 4NLEA 2JAUA 2QGAB 3E04A 5EYTA 4YIHA 2O7EA 1XMDA 1XMCA 3F4TA 2PTRA 3QBPA 4V2RA 1K7WA 3TV2A 1T6JA 1VDKA 4V2QA 5F92A 2QVEA 4MX2A 4IQJM 2YV5A 1U16A 2PTSA 1B8FA 2E9FA 4NSLA 2PTQA 1Y2MA 4E88A 1C3UA 2O7FA
chains in the Genus database with same CATH topology
1TJUA 2RJRA 4FLCA 1FUQA 2OHYA 1YFMA 5D6BA 5HW2A 4C5SA 3NO9A 2PFMA 3C8TA 1YFEA 2O7BA 2RJSA 4CQ5A 1C3CA 4C6GA 1FURA 3RRPA 4EFCA 5EYVA 1DCNA 3UNVA 5F91A 1J3UA 3NZ4A 2FUSA 2O7DA 2O6YA 4FFXA 3R6QA 3KDZA 2YIIA 1GKJA 2J91A 1U15A 4APBA 3GZHA 1TJ7A 2NYNA 4EEIA 3R6VA 1K62A 3BHGA 1T6PA 1AUWA 4C5UA 1FUOA 1HY0A 2X75A 4APAA 4C5RA 1TJVA 1XWOA 2VD6A 1I0AA 3KDYA 4BABA 1GK3A 3RD8A 3OCEA 4ADMA 1FUPA 4HGVA 1GK2A 4ADLA 3OCFA 1Q5NA 1DOFA 2NYFA 3GTDA 4BAAA 1YISA 1JSWA 1HY1A 3CZOA 3R6YA 1KQ7A 1W27A 1TJWA 1EB4A 1RE5A 1GKMA 2O78A 2HVGA 4NLEA 2QGAB 3E04A 5EYTA 2O7EA 4V2RA 2PTRA 3QBPA 1K7WA 3TV2A 1T6JA 1VDKA 4V2QA 5F92A 2QVEA 4MX2A 1U16A 2PTSA 1B8FA 2E9FA 4NSLA 2PTQA 1Y2MA 1C3UA 2O7FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TJU A;  2RJR A;  4FLC A;  1FUQ A;  2OHY A;  1YFM A;  5D6B A;  5HW2 A;  4C5S A;  3NO9 A;  2PFM A;  3C8T A;  1YFE A;  2O7B A;  2RJS A;  4CQ5 A;  1C3C A;  4C6G A;  1FUR A;  3RRP A;  4EFC A;  5EYV A;  1DCN A;  3UNV A;  5F91 A;  1J3U A;  3NZ4 A;  2FUS A;  2O7D A;  2O6Y A;  4FFX A;  3R6Q A;  3KDZ A;  2YII A;  1GKJ A;  2J91 A;  1U15 A;  4APB A;  3GZH A;  1TJ7 A;  2NYN A;  4EEI A;  3R6V A;  1K62 A;  3BHG A;  1T6P A;  1AUW A;  4C5U A;  1FUO A;  1HY0 A;  2X75 A;  4APA A;  4C5R A;  1TJV A;  1XWO A;  2VD6 A;  1I0A A;  3KDY A;  4BAB A;  1GK3 A;  3RD8 A;  3OCE A;  4ADM A;  1FUP A;  4HGV A;  1GK2 A;  4ADL A;  3OCF A;  1Q5N A;  1DOF A;  2NYF A;  3GTD A;  4BAA A;  1YIS A;  1JSW A;  1HY1 A;  3CZO A;  3R6Y A;  1KQ7 A;  1W27 A;  1TJW A;  1EB4 A;  1RE5 A;  1GKM A;  2O78 A;  2HVG A;  4NLE A;  2QGA B;  3E04 A;  5EYT A;  2O7E A;  4V2R A;  2PTR A;  3QBP A;  1K7W A;  3TV2 A;  1T6J A;  1VDK A;  4V2Q A;  5F92 A;  2QVE A;  4MX2 A;  1U16 A;  2PTS A;  1B8F A;  2E9F A;  4NSL A;  2PTQ A;  1Y2M A;  1C3U A;  2O7F A; 
#chains in the Genus database with same CATH topology
 5M0J A;  1TJU A;  4NFL A;  2RJR A;  1Z4M A;  1Z4J A;  4FLC A;  1FUQ A;  4L6A A;  2OHY A;  1YFM A;  2RCN A;  5D6B A;  3U13 A;  5HW2 A;  4C5S A;  3NO9 A;  2PFM A;  2I7D A;  1MH9 A;  3C8T A;  1YFE A;  2O7B A;  5M0I A;  2RJS A;  4CQ5 A;  1C3C A;  4C6G A;  1FUR A;  3RRP A;  4EFC A;  5EYV A;  1DCN A;  3UNV A;  1Z4K A;  1Z4I A;  5F91 A;  4L6C A;  1J3U A;  3NZ4 A;  2FUS A;  2O7D A;  2O6Y A;  4FFX A;  5H8W A;  3R6Q A;  3KDZ A;  3F4R A;  1Z4Q A;  2YII A;  1GKJ A;  2J91 A;  1U15 A;  4APB A;  3GZH A;  1TJ7 A;  2NYN A;  4EEI A;  3R6V A;  2D27 A;  4A15 A;  1K62 A;  3BHG A;  1T6P A;  1AUW A;  4C5U A;  1FUO A;  4MWO A;  2FEL A;  1HY0 A;  2X75 A;  3U19 A;  4APA A;  3CRV A;  3CRW 1;  4C5R A;  3CI0 K;  1Z4L A;  2FEN A;  1TJV A;  1Z4P X;  4YIK A;  2JAO A;  1U0L A;  1XWO A;  2VD6 A;  2VL7 A;  1I0A A;  1Q91 A;  4L57 A;  3KDY A;  4BAB A;  1XL8 A;  4WNL A;  1GK3 A;  3BWV A;  3RD8 A;  3OCE A;  4ADM A;  1FUP A;  4HGV A;  4ADL A;  1GK2 A;  3OCF A;  1DOF A;  1Q5N A;  1Q92 A;  2NYF A;  3GTD A;  4BAA A;  1XL7 A;  3F4S A;  2D28 C;  1YIS A;  1JSW A;  1HY1 A;  3CZO A;  3R6Y A;  1KQ7 A;  1T9H A;  2JAW A;  1W27 A;  1TJW A;  1EB4 A;  4MUM A;  1RE5 A;  2VSF A;  1GKM A;  2O78 A;  1XLY A;  1IW7 D;  2HVG A;  2JAR A;  4NLE A;  2JAU A;  2QGA B;  3E04 A;  5EYT A;  4YIH A;  2O7E A;  1XMD A;  1XMC A;  3F4T A;  2PTR A;  3QBP A;  4V2R A;  1K7W A;  3TV2 A;  1T6J A;  1VDK A;  4V2Q A;  5F92 A;  2QVE A;  4MX2 A;  4IQJ M;  2YV5 A;  1U16 A;  2PTS A;  1B8F A;  2E9F A;  4NSL A;  2PTQ A;  1Y2M A;  4E88 A;  1C3U A;  2O7F A; 
#chains in the Genus database with same CATH homology
 1TJU A;  2RJR A;  4FLC A;  1FUQ A;  2OHY A;  1YFM A;  5D6B A;  5HW2 A;  4C5S A;  3NO9 A;  2PFM A;  3C8T A;  1YFE A;  2O7B A;  2RJS A;  4CQ5 A;  1C3C A;  4C6G A;  1FUR A;  3RRP A;  4EFC A;  5EYV A;  1DCN A;  3UNV A;  5F91 A;  1J3U A;  3NZ4 A;  2FUS A;  2O7D A;  2O6Y A;  4FFX A;  3R6Q A;  3KDZ A;  2YII A;  1GKJ A;  2J91 A;  1U15 A;  4APB A;  3GZH A;  1TJ7 A;  2NYN A;  4EEI A;  3R6V A;  1K62 A;  3BHG A;  1T6P A;  1AUW A;  4C5U A;  1FUO A;  1HY0 A;  2X75 A;  4APA A;  4C5R A;  1TJV A;  1XWO A;  2VD6 A;  1I0A A;  3KDY A;  4BAB A;  1GK3 A;  3RD8 A;  3OCE A;  4ADM A;  1FUP A;  4HGV A;  1GK2 A;  4ADL A;  3OCF A;  1Q5N A;  1DOF A;  2NYF A;  3GTD A;  4BAA A;  1YIS A;  1JSW A;  1HY1 A;  3CZO A;  3R6Y A;  1KQ7 A;  1W27 A;  1TJW A;  1EB4 A;  1RE5 A;  1GKM A;  2O78 A;  2HVG A;  4NLE A;  2QGA B;  3E04 A;  5EYT A;  2O7E A;  4V2R A;  2PTR A;  3QBP A;  1K7W A;  3TV2 A;  1T6J A;  1VDK A;  4V2Q A;  5F92 A;  2QVE A;  4MX2 A;  1U16 A;  2PTS A;  1B8F A;  2E9F A;  4NSL A;  2PTQ A;  1Y2M A;  1C3U A;  2O7F A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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