4IO9S

Crystal structure of compound 4d bound to large ribosomal subunit (50s) from deinococcus radiodurans
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
175
structure length
175
Chain Sequence
MELTAKPRTPKQKLDESMIAAVAYNKENNVSFALDRKAFDRAFRQQSTTGLFDITVEGGETFPALVKAVQMDKRKRAPIHVDFYMVTYGEPVEVSVPVHTTGRSQGEVQGGLVDIVVHNLQIVAPGPRRIPQELVVDVTKMNIGDHITAGDIKLPEGCTLAADPELTVVSVLPPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates.
pubmed doi rcsb
molecule tags Ribosome/ribosome inhibitor
molecule keywords 23S ribosomal RNA
total genus 28
structure length 175
sequence length 175
ec nomenclature
pdb deposition date 2013-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 4io9S01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 4io9S02
2HZ7A 2RD2A 1EUQA 5GAGW 5HL7S 1GTRA 5JVHS 1D6KA 4JXZA 5GAHW 4WFNS 4H3SA 2RE8A 1O0BA 1ZJWA 1QRTA 3DLLS 1QRSA 5DM7S 4IOAS 3CF5S 1QTQA 4JXXA 5DM6S 4WCES 4P2BA 4WFBS 2ZJQS 4IO9S 5GADW 3PIPS 1EUYA 5BNZA 1O0CA 4UY88 1DFUP 3PIOS 4IOCS 1EXDA 1B75A 4WFAS 3AIIA 5GAEW 2ZJPS 5JVGS 4JYZA 1GTSA 5IZNA 3J7ZV 1QRUA 4WF9S 4U67S 1NYLA 1FEUA 2ZJRS
chains in the Genus database with same CATH superfamily
2HZ7A 2RD2A 2NVTC 1TWGC 2L5NA 3M3YC 4KN7A 3CZBA 5C4JC 3S16C 1V6ZA 3FKIC 2PPBA 5JVHS 4KMUA 4XSZA 5IP7C 1D6KA 4XLNA 4G7OA 4OIOA 4QJVA 3PO2C 2GAEA 5IYBC 4OINA 1ZJWA 4A3LC 5HQHA 2YU9C 4A3BC 1HQMA 3CF5S 2A6EA 4BY7C 2A68A 4MQ9A 5IYCC 4E8BA 4XLPA 4C3IC 1BDFA 2JA6C 4WFBS 4IO9S 1VHKA 1Y1VC 5TMCA 4BY1C 5IP9C 1YNNA 2B63C 1EXDA 2JA7C 4YFXA 3W2WB 4YFKA 2PA8D 4WFAS 3DXJA 2ZJPS 4A3KC 4OIPA 2CX8A 1GTSA 4XSXA 3KW2A 1Y1WC 4U67S 1I3QC 1NYLA 4LK0A 2NVXC 3S2HC 3S15C 3M4OC 5GAGW 5HL7S 2E2JC 3K7AC 2Y0SD 4NOIA 3GTJC 2WAQD 3GTQC 4BBSC 2EGVA 1ZYRA 4WFNS 1TWFC 3H3VD 4OIQA 3DLLS 1QRSA 3EQLA 4A3MC 2PI8A 4BXXC 4LK1A 2PJJA 4G7ZA 4JXXA 2JA5C 1WCMC 3S1RC 2ZJQS 2E2IC 1EUYA 2Z0YA 1DFUP 4IOCS 4C2MC 4G7HA 4JK1A 5JVGS 5TMFA 4X6AC 4A3JC 2L3UA 1TWHC 4ZH4A 2E2HC 3LYWA 3S1NC 4Q4ZA 2R93C 3HOYC 1I6HC 3WODA 3GTLC 1EUQA 3HOUC 3I4MC 1GTRA 4A93C 5FLMC 2R92C 3PO3C 4C3HC 2A6HA 2WB1D 4JXZA 3HOZC 4L69A 3RZOC 5C4XC 4H3SA 2RE8A 2JA8C 2NVYC 1R9TC 2VUMC 1I6VA 2PMZD 3GTMC 2O5IA 4C3JC 3S1QC 4Y7NC 2G6GA 4LJZA 2PICA 5DM6S 4WCES 4BBRC 4A3EC 3RZDC 4P2BA 1SFOC 1VHYA 3HKZD 5BNZA 1O0CA 1YNJA 4A3DC 3PIOS 5C3EC 4H4KA 1TWAC 4YFNA 2CW0A 4YG2A 5D4DA 3AIIA 5GAEW 4JYZA 4AYBD 5IZNA 3J7ZV 1QRUA 3S17C 2O5JA 2KXYA 3HOVC 2NWAA 2BE5A 4Y52C 1I50C 1IW7A 2NVQC 4QIWD 3GTOC 2A69A 3CQZC 3GTGC 3X1LB 2KPUA 4Q5SA 4LLGA 5GAHW 4A3IC 3HOXC 3GTPC 2R7ZC 1O0BA 4MEYA 3S1MC 1QRTA 5IYDC 1NXZA 5C44C 3H0GC 3I4NC 4KN4A 5DM7S 4V194 3GTKC 4IOAS 3W2VB 1SMYA 1K83C 3HOWC 3S14C 1QTQA 4J3CA 2G5DA 2KQ1A 4MEXA 4UY88 5GADW 3PIPS 4OIRA 4A3GC 2EGWA 1B75A 3S2DC 2PNWA 4A3CC 1Z85A 4GZYA 2AE0X 1TWCC 4WF9S 1UDXA 1FEUA 4A3FC 2ZJRS
chains in the Genus database with same CATH topology
2HZ7A 2RD2A 1EUQA 5GAGW 5HL7S 1GTRA 3X1LB 5JVHS 1D6KA 4JXZA 5GAHW 4WFNS 4H3SA 2RE8A 1O0BA 1ZJWA 1QRTA 3DLLS 1QRSA 5DM7S 4V194 4IOAS 3W2VB 3CF5S 1QTQA 4JXXA 5DM6S 4WCES 4P2BA 4WFBS 2ZJQS 4IO9S 5GADW 3PIPS 1EUYA 5BNZA 1O0CA 4UY88 1DFUP 3PIOS 4IOCS 4H4KA 1EXDA 1B75A 3W2WB 4WFAS 3AIIA 5GAEW 2ZJPS 5JVGS 4JYZA 1GTSA 5IZNA 3J7ZV 1QRUA 4WF9S 4U67S 1UDXA 1NYLA 1FEUA 2ZJRS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HZ7 A;  2RD2 A;  1EUQ A;  5GAG W;  5HL7 S;  1GTR A;  5JVH S;  1D6K A;  4JXZ A;  5GAH W;  4WFN S;  4H3S A;  2RE8 A;  1O0B A;  1ZJW A;  1QRT A;  3DLL S;  1QRS A;  5DM7 S;  4IOA S;  3CF5 S;  1QTQ A;  4JXX A;  5DM6 S;  4WCE S;  4P2B A;  4WFB S;  2ZJQ S;  4IO9 S;  5GAD W;  3PIP S;  1EUY A;  5BNZ A;  1O0C A;  4UY8 8;  1DFU P;  3PIO S;  4IOC S;  1EXD A;  1B75 A;  4WFA S;  3AII A;  5GAE W;  2ZJP S;  5JVG S;  4JYZ A;  1GTS A;  5IZN A;  3J7Z V;  1QRU A;  4WF9 S;  4U67 S;  1NYL A;  1FEU A;  2ZJR S; 
#chains in the Genus database with same CATH topology
 2HZ7 A;  2RD2 A;  2NVT C;  1TWG C;  2L5N A;  3M3Y C;  4KN7 A;  3CZB A;  5C4J C;  3S16 C;  1V6Z A;  3FKI C;  2PPB A;  5JVH S;  4KMU A;  4XSZ A;  5IP7 C;  1D6K A;  4XLN A;  4G7O A;  4OIO A;  4QJV A;  3PO2 C;  2GAE A;  5IYB C;  4OIN A;  1ZJW A;  4A3L C;  5HQH A;  2YU9 C;  4A3B C;  1HQM A;  3CF5 S;  2A6E A;  4BY7 C;  2A68 A;  4MQ9 A;  5IYC C;  4E8B A;  4XLP A;  4C3I C;  1BDF A;  2JA6 C;  4WFB S;  4IO9 S;  1VHK A;  1Y1V C;  5TMC A;  4BY1 C;  5IP9 C;  1YNN A;  2B63 C;  1EXD A;  2JA7 C;  4YFX A;  3W2W B;  4YFK A;  2PA8 D;  4WFA S;  3DXJ A;  2ZJP S;  4A3K C;  4OIP A;  2CX8 A;  1GTS A;  4XSX A;  3KW2 A;  1Y1W C;  4U67 S;  1I3Q C;  1NYL A;  4LK0 A;  2NVX C;  3S2H C;  3S15 C;  3M4O C;  5GAG W;  5HL7 S;  2E2J C;  3K7A C;  2Y0S D;  4NOI A;  3GTJ C;  2WAQ D;  3GTQ C;  4BBS C;  2EGV A;  1ZYR A;  4WFN S;  1TWF C;  3H3V D;  4OIQ A;  3DLL S;  1QRS A;  3EQL A;  4A3M C;  2PI8 A;  4BXX C;  4LK1 A;  2PJJ A;  4G7Z A;  4JXX A;  2JA5 C;  1WCM C;  3S1R C;  2ZJQ S;  2E2I C;  1EUY A;  2Z0Y A;  1DFU P;  4IOC S;  4C2M C;  4G7H A;  4JK1 A;  5JVG S;  5TMF A;  4X6A C;  4A3J C;  2L3U A;  1TWH C;  4ZH4 A;  2E2H C;  3LYW A;  3S1N C;  4Q4Z A;  2R93 C;  3HOY C;  1I6H C;  3WOD A;  3GTL C;  1EUQ A;  3HOU C;  3I4M C;  1GTR A;  4A93 C;  5FLM C;  2R92 C;  3PO3 C;  4C3H C;  2A6H A;  2WB1 D;  4JXZ A;  3HOZ C;  4L69 A;  3RZO C;  5C4X C;  4H3S A;  2RE8 A;  2JA8 C;  2NVY C;  1R9T C;  2VUM C;  1I6V A;  2PMZ D;  3GTM C;  2O5I A;  4C3J C;  3S1Q C;  4Y7N C;  2G6G A;  4LJZ A;  2PIC A;  5DM6 S;  4WCE S;  4BBR C;  4A3E C;  3RZD C;  4P2B A;  1SFO C;  1VHY A;  3HKZ D;  5BNZ A;  1O0C A;  1YNJ A;  4A3D C;  3PIO S;  5C3E C;  4H4K A;  1TWA C;  4YFN A;  2CW0 A;  4YG2 A;  5D4D A;  3AII A;  5GAE W;  4JYZ A;  4AYB D;  5IZN A;  3J7Z V;  1QRU A;  3S17 C;  2O5J A;  2KXY A;  3HOV C;  2NWA A;  2BE5 A;  4Y52 C;  1I50 C;  1IW7 A;  2NVQ C;  4QIW D;  3GTO C;  2A69 A;  3CQZ C;  3GTG C;  3X1L B;  2KPU A;  4Q5S A;  4LLG A;  5GAH W;  4A3I C;  3HOX C;  3GTP C;  2R7Z C;  1O0B A;  4MEY A;  3S1M C;  1QRT A;  5IYD C;  1NXZ A;  5C44 C;  3H0G C;  3I4N C;  4KN4 A;  5DM7 S;  4V19 4;  3GTK C;  4IOA S;  3W2V B;  1SMY A;  1K83 C;  3HOW C;  3S14 C;  1QTQ A;  4J3C A;  2G5D A;  2KQ1 A;  4MEX A;  4UY8 8;  5GAD W;  3PIP S;  4OIR A;  4A3G C;  2EGW A;  1B75 A;  3S2D C;  2PNW A;  4A3C C;  1Z85 A;  4GZY A;  2AE0 X;  1TWC C;  4WF9 S;  1UDX A;  1FEU A;  4A3F C;  2ZJR S; 
#chains in the Genus database with same CATH homology
 2HZ7 A;  2RD2 A;  1EUQ A;  5GAG W;  5HL7 S;  1GTR A;  3X1L B;  5JVH S;  1D6K A;  4JXZ A;  5GAH W;  4WFN S;  4H3S A;  2RE8 A;  1O0B A;  1ZJW A;  1QRT A;  3DLL S;  1QRS A;  5DM7 S;  4V19 4;  4IOA S;  3W2V B;  3CF5 S;  1QTQ A;  4JXX A;  5DM6 S;  4WCE S;  4P2B A;  4WFB S;  2ZJQ S;  4IO9 S;  5GAD W;  3PIP S;  1EUY A;  5BNZ A;  1O0C A;  4UY8 8;  1DFU P;  3PIO S;  4IOC S;  4H4K A;  1EXD A;  1B75 A;  3W2W B;  4WFA S;  3AII A;  5GAE W;  2ZJP S;  5JVG S;  4JYZ A;  1GTS A;  5IZN A;  3J7Z V;  1QRU A;  4WF9 S;  4U67 S;  1UDX A;  1NYL A;  1FEU A;  2ZJR S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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