4IOAS

Crystal structure of compound 4e bound to large ribosomal subunit (50s) from deinococcus radiodurans
Total Genus 25
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
175
structure length
175
Chain Sequence
MELTAKPRTPKQKLDESMIAAVAYNKENNVSFALDRKAFDRAFRQQSTTGLFDITVEGGETFPALVKAVQMDKRKRAPIHVDFYMVTYGEPVEVSVPVHTTGRSQGEVQGGLVDIVVHNLQIVAPGPRRIPQELVVDVTKMNIGDHITAGDIKLPEGCTLAADPELTVVSVLPPR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Ribosome/ribosome inhibitor
publication title Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates.
pubmed doi rcsb
molecule keywords 23S ribosomal RNA
total genus 25
structure length 175
sequence length 175
ec nomenclature
pdb deposition date 2013-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 4ioaS01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 4ioaS02
1EUYA 4UY88 2HZ7A 5DM6S 3PIPS 4JXXA 3DLLS 1QRTA 2RD2A 5GADW 5JVHS 1O0CA 2ZJQS 2RE8A 1ZJWA 5IZNA 1EXDA 2ZJPS 4H3SA 5DM7S 4U67S 1QRSA 5GAEW 5JVGS 1QRUA 1NYLA 1QTQA 5GAGW 1FEUA 1O0BA 1GTRA 3CF5S 3J7ZV 4IOAS 4JYZA 5BNZA 4WFAS 4P2BA 4WCES 1DFUP 4IOCS 5GAHW 4WFBS 3PIOS 4IO9S 1GTSA 4WFNS 4JXZA 3AIIA 4WF9S 1D6KA 5HL7S 1B75A 1EUQA 2ZJRS
chains in the Genus database with same CATH superfamily
3KW2A 1TWGC 1R9TC 1TWAC 5C3EC 1VHYA 3GTKC 2PI8A 4QIWD 4YFXA 3HOYC 3GTQC 1O0CA 1YNNA 2ZJQS 4MEXA 1WCMC 4LK1A 1EXDA 3S2DC 3GTPC 4G7ZA 5IYBC 4U67S 3S14C 2E2HC 3S16C 4YFNA 3DXJA 5C4XC 1TWFC 1QRUA 1NYLA 1QTQA 4AYBD 2A6EA 2PMZD 1K83C 4BBRC 2EGVA 3J7ZV 4IOAS 4XSZA 2JA5C 4JYZA 4A3KC 1IW7A 4YG2A 4XLPA 4G7HA 4Q4ZA 2A6HA 3PIOS 2NVQC 2R92C 4XSXA 3GTOC 5BNZA 4KN7A 1NXZA 4A3CC 4UY88 3I4MC 3S1QC 3HOZC 2EGWA 4A3LC 5C44C 2VUMC 2R93C 4V194 5FLMC 3HKZD 3CZBA 4LK0A 5C4JC 2RE8A 4YFKA 4OIQA 3S15C 5IZNA 4C3IC 4QJVA 3PO3C 3S2HC 4H3SA 1QRSA 2JA8C 3M3YC 2NVXC 2A68A 4KN4A 2JA6C 5TMFA 1I6VA 2PPBA 1HQMA 1BDFA 5HQHA 1SFOC 2AE0X 5IP7C 1UDXA 2Z0YA 4A3FC 1Y1WC 3M4OC 4G7OA 1ZYRA 2O5JA 4J3CA 3HOVC 5IP9C 4P2BA 4WCES 2CX8A 1DFUP 3S17C 4BY7C 4C3JC 3CQZC 5IYDC 4C3HC 4Y52C 2L5NA 4NOIA 4GZYA 3S1MC 1D6KA 4X6AC 5HL7S 3CF5S 3LYWA 1B75A 2E2IC 1EUQA 2ZJRS 1EUYA 5DM6S 3PIPS 2NVYC 4A3GC 1I6HC 5JVHS 5GADW 4Y7NC 3WODA 3GTJC 1VHKA 3HOXC 1ZJWA 5TMCA 2GAEA 3RZDC 3PO2C 4A3EC 5DM7S 4JK1A 3X1LB 2PJJA 1SMYA 2KPUA 2JA7C 4OIPA 2KXYA 3RZOC 1I3QC 5GAGW 1O0BA 2CW0A 4A3DC 4KMUA 2G5DA 3S1RC 2BE5A 3GTLC 1I50C 4Q5SA 5D4DA 2NVTC 2KQ1A 4IOCS 4IO9S 4WFBS 4XLNA 4WFNS 4JXZA 3H0GC 3I4NC 1V6ZA 2O5IA 3FKIC 4A3MC 4LJZA 4LLGA 2HZ7A 4OIRA 4JXXA 4MEYA 2R7ZC 3DLLS 4L69A 1QRTA 2PA8D 2RD2A 2G6GA 2WB1D 3H3VD 3HOWC 4A3JC 1Y1VC 4BY1C 4A3BC 4E8BA 4ZH4A 2L3UA 4OIOA 4C2MC 2ZJPS 4A3IC 4H4KA 2B63C 3HOUC 5GAEW 5JVGS 2WAQD 2Y0SD 3W2VB 2A69A 1FEUA 4BXXC 2E2JC 2YU9C 4OINA 2PICA 4WFAS 5IYCC 1YNJA 1Z85A 2NWAA 1TWCC 2PNWA 5GAHW 1TWHC 1GTSA 3EQLA 4A93C 3AIIA 4BBSC 3S1NC 4WF9S 3GTMC 3GTGC 1GTRA 3W2WB 3K7AC 4MQ9A
chains in the Genus database with same CATH topology
1EUYA 4UY88 2HZ7A 5DM6S 3PIPS 4JXXA 3DLLS 1QRTA 2RD2A 5GADW 5JVHS 1O0CA 4V194 2ZJQS 2RE8A 1ZJWA 5IZNA 1EXDA 2ZJPS 4H3SA 4H4KA 5DM7S 4U67S 1QRSA 5GAEW 5JVGS 3X1LB 3W2VB 1QRUA 1NYLA 1QTQA 5GAGW 1FEUA 1O0BA 1GTRA 3CF5S 1UDXA 3J7ZV 4IOAS 4JYZA 5BNZA 4WFAS 4P2BA 4WCES 1DFUP 4IOCS 5GAHW 4WFBS 3PIOS 4IO9S 1GTSA 4WFNS 4JXZA 3AIIA 4WF9S 1D6KA 3W2WB 5HL7S 1B75A 1EUQA 2ZJRS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EUY A;  4UY8 8;  2HZ7 A;  5DM6 S;  3PIP S;  4JXX A;  3DLL S;  1QRT A;  2RD2 A;  5GAD W;  5JVH S;  1O0C A;  2ZJQ S;  2RE8 A;  1ZJW A;  5IZN A;  1EXD A;  2ZJP S;  4H3S A;  5DM7 S;  4U67 S;  1QRS A;  5GAE W;  5JVG S;  1QRU A;  1NYL A;  1QTQ A;  5GAG W;  1FEU A;  1O0B A;  1GTR A;  3CF5 S;  3J7Z V;  4IOA S;  4JYZ A;  5BNZ A;  4WFA S;  4P2B A;  4WCE S;  1DFU P;  4IOC S;  5GAH W;  4WFB S;  3PIO S;  4IO9 S;  1GTS A;  4WFN S;  4JXZ A;  3AII A;  4WF9 S;  1D6K A;  5HL7 S;  1B75 A;  1EUQ A;  2ZJR S; 
#chains in the Genus database with same CATH topology
 3KW2 A;  1TWG C;  1R9T C;  1TWA C;  5C3E C;  1VHY A;  3GTK C;  2PI8 A;  4QIW D;  4YFX A;  3HOY C;  3GTQ C;  1O0C A;  1YNN A;  2ZJQ S;  4MEX A;  1WCM C;  4LK1 A;  1EXD A;  3S2D C;  3GTP C;  4G7Z A;  5IYB C;  4U67 S;  3S14 C;  2E2H C;  3S16 C;  4YFN A;  3DXJ A;  5C4X C;  1TWF C;  1QRU A;  1NYL A;  1QTQ A;  4AYB D;  2A6E A;  2PMZ D;  1K83 C;  4BBR C;  2EGV A;  3J7Z V;  4IOA S;  4XSZ A;  2JA5 C;  4JYZ A;  4A3K C;  1IW7 A;  4YG2 A;  4XLP A;  4G7H A;  4Q4Z A;  2A6H A;  3PIO S;  2NVQ C;  2R92 C;  4XSX A;  3GTO C;  5BNZ A;  4KN7 A;  1NXZ A;  4A3C C;  4UY8 8;  3I4M C;  3S1Q C;  3HOZ C;  2EGW A;  4A3L C;  5C44 C;  2VUM C;  2R93 C;  4V19 4;  5FLM C;  3HKZ D;  3CZB A;  4LK0 A;  5C4J C;  2RE8 A;  4YFK A;  4OIQ A;  3S15 C;  5IZN A;  4C3I C;  4QJV A;  3PO3 C;  3S2H C;  4H3S A;  1QRS A;  2JA8 C;  3M3Y C;  2NVX C;  2A68 A;  4KN4 A;  2JA6 C;  5TMF A;  1I6V A;  2PPB A;  1HQM A;  1BDF A;  5HQH A;  1SFO C;  2AE0 X;  5IP7 C;  1UDX A;  2Z0Y A;  4A3F C;  1Y1W C;  3M4O C;  4G7O A;  1ZYR A;  2O5J A;  4J3C A;  3HOV C;  5IP9 C;  4P2B A;  4WCE S;  2CX8 A;  1DFU P;  3S17 C;  4BY7 C;  4C3J C;  3CQZ C;  5IYD C;  4C3H C;  4Y52 C;  2L5N A;  4NOI A;  4GZY A;  3S1M C;  1D6K A;  4X6A C;  5HL7 S;  3CF5 S;  3LYW A;  1B75 A;  2E2I C;  1EUQ A;  2ZJR S;  1EUY A;  5DM6 S;  3PIP S;  2NVY C;  4A3G C;  1I6H C;  5JVH S;  5GAD W;  4Y7N C;  3WOD A;  3GTJ C;  1VHK A;  3HOX C;  1ZJW A;  5TMC A;  2GAE A;  3RZD C;  3PO2 C;  4A3E C;  5DM7 S;  4JK1 A;  3X1L B;  2PJJ A;  1SMY A;  2KPU A;  2JA7 C;  4OIP A;  2KXY A;  3RZO C;  1I3Q C;  5GAG W;  1O0B A;  2CW0 A;  4A3D C;  4KMU A;  2G5D A;  3S1R C;  2BE5 A;  3GTL C;  1I50 C;  4Q5S A;  5D4D A;  2NVT C;  2KQ1 A;  4IOC S;  4IO9 S;  4WFB S;  4XLN A;  4WFN S;  4JXZ A;  3H0G C;  3I4N C;  1V6Z A;  2O5I A;  3FKI C;  4A3M C;  4LJZ A;  4LLG A;  2HZ7 A;  4OIR A;  4JXX A;  4MEY A;  2R7Z C;  3DLL S;  4L69 A;  1QRT A;  2PA8 D;  2RD2 A;  2G6G A;  2WB1 D;  3H3V D;  3HOW C;  4A3J C;  1Y1V C;  4BY1 C;  4A3B C;  4E8B A;  4ZH4 A;  2L3U A;  4OIO A;  4C2M C;  2ZJP S;  4A3I C;  4H4K A;  2B63 C;  3HOU C;  5GAE W;  5JVG S;  2WAQ D;  2Y0S D;  3W2V B;  2A69 A;  1FEU A;  4BXX C;  2E2J C;  2YU9 C;  4OIN A;  2PIC A;  4WFA S;  5IYC C;  1YNJ A;  1Z85 A;  2NWA A;  1TWC C;  2PNW A;  5GAH W;  1TWH C;  1GTS A;  3EQL A;  4A93 C;  3AII A;  4BBS C;  3S1N C;  4WF9 S;  3GTM C;  3GTG C;  1GTR A;  3W2W B;  3K7A C;  4MQ9 A; 
#chains in the Genus database with same CATH homology
 1EUY A;  4UY8 8;  2HZ7 A;  5DM6 S;  3PIP S;  4JXX A;  3DLL S;  1QRT A;  2RD2 A;  5GAD W;  5JVH S;  1O0C A;  4V19 4;  2ZJQ S;  2RE8 A;  1ZJW A;  5IZN A;  1EXD A;  2ZJP S;  4H3S A;  4H4K A;  5DM7 S;  4U67 S;  1QRS A;  5GAE W;  5JVG S;  3X1L B;  3W2V B;  1QRU A;  1NYL A;  1QTQ A;  5GAG W;  1FEU A;  1O0B A;  1GTR A;  3CF5 S;  1UDX A;  3J7Z V;  4IOA S;  4JYZ A;  5BNZ A;  4WFA S;  4P2B A;  4WCE S;  1DFU P;  4IOC S;  5GAH W;  4WFB S;  3PIO S;  4IO9 S;  1GTS A;  4WFN S;  4JXZ A;  3AII A;  4WF9 S;  1D6K A;  3W2W B;  5HL7 S;  1B75 A;  1EUQ A;  2ZJR S; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...