4IOAS

Crystal structure of compound 4e bound to large ribosomal subunit (50s) from deinococcus radiodurans
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
175
structure length
175
Chain Sequence
MELTAKPRTPKQKLDESMIAAVAYNKENNVSFALDRKAFDRAFRQQSTTGLFDITVEGGETFPALVKAVQMDKRKRAPIHVDFYMVTYGEPVEVSVPVHTTGRSQGEVQGGLVDIVVHNLQIVAPGPRRIPQELVVDVTKMNIGDHITAGDIKLPEGCTLAADPELTVVSVLPPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates.
pubmed doi rcsb
molecule tags Ribosome/ribosome inhibitor
molecule keywords 23S ribosomal RNA
total genus 25
structure length 175
sequence length 175
ec nomenclature
pdb deposition date 2013-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 4ioaS01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 4ioaS02
2ZJQS 4WCES 1EXDA 1GTRA 1O0BA 3PIPS 5GAEW 3PIOS 5GAGW 3J7ZV 4WF9S 1QRUA 4UY88 1B75A 2HZ7A 2ZJPS 1ZJWA 1D6KA 4WFNS 5JVHS 2RD2A 5GAHW 3AIIA 1QRSA 3CF5S 4U67S 1FEUA 5HL7S 1EUQA 4P2BA 4IO9S 4IOCS 4JXZA 1EUYA 5JVGS 1O0CA 4WFBS 5BNZA 1NYLA 3DLLS 1DFUP 1QRTA 5DM6S 4JXXA 2RE8A 4JYZA 5IZNA 1GTSA 4H3SA 2ZJRS 1QTQA 5GADW 5DM7S 4WFAS 4IOAS
chains in the Genus database with same CATH superfamily
2ZJQS 3S2DC 4L69A 3HOZC 4A3MC 3M3YC 2Z0YA 4G7ZA 4YFNA 3HKZD 2PI8A 1TWAC 1V6ZA 2A68A 3W2WB 2BE5A 4Y7NC 3GTKC 1VHKA 1QRUA 4X6AC 2ZJPS 4KN7A 4E8BA 4WFNS 3S1RC 5GAHW 4XSZA 1QRSA 4LK0A 1IW7A 5TMFA 5HL7S 1TWFC 4IO9S 1Z85A 2PJJA 4IOCS 1Y1VC 1EUYA 4A3JC 2O5IA 5D4DA 1I3QC 2G6GA 4MQ9A 3WODA 1I6HC 1TWCC 2R92C 4OINA 2PNWA 4JYZA 4BBSC 2PMZD 4H3SA 2VUMC 3HOYC 2O5JA 4OIOA 5TMCA 3S2HC 3GTLC 4V194 1O0BA 1UDXA 2NVYC 2EGVA 3LYWA 5IP7C 1Y1WC 4J3CA 1HQMA 2A6EA 2WB1D 3KW2A 3J7ZV 4C3JC 4UY88 5IYBC 5IYCC 3PO2C 3RZDC 1R9TC 3K7AC 4GZYA 1ZYRA 2CW0A 3AIIA 4MEXA 2CX8A 4A3EC 2R7ZC 3S14C 3S15C 4BY7C 2E2IC 4A3GC 4U67S 2NWAA 1EUQA 4A3IC 2GAEA 2B63C 1O0CA 4WFBS 5DM6S 4A3KC 1NXZA 2KXYA 3M4OC 4KN4A 2NVQC 2HZ7A 2YU9C 4IOAS 4LLGA 4WFAS 4YG2A 4WCES 4LK1A 3GTMC 2KQ1A 5FLMC 3HOWC 3PIPS 4C3HC 5IYDC 3EQLA 3PIOS 5GAGW 2AE0X 5HQHA 3GTOC 4QIWD 3X1LB 5C44C 4OIRA 1TWGC 3GTGC 2RD2A 5C4JC 3S17C 2EGWA 5C4XC 1VHYA 4OIPA 4G7HA 2Y0SD 4AYBD 3CF5S 2JA6C 1SMYA 1FEUA 4P2BA 3DXJA 3W2VB 4KMUA 4JK1A 3H3VD 4Q5SA 1TWHC 1NYLA 5BNZA 5IP9C 2G5DA 4JXXA 2L3UA 5IZNA 3PO3C 2PA8D 4BBRC 5C3EC 4A3BC 2R93C 2KPUA 3S1MC 4BXXC 1QTQA 4YFKA 5GADW 2NVTC 5DM7S 4A3DC 4BY1C 3HOUC 4A93C 1EXDA 3CZBA 1GTRA 4LJZA 4A3CC 5GAEW 4ZH4A 4A3FC 2NVXC 2PICA 4NOIA 4WF9S 2A69A 1SFOC 2JA7C 4C2MC 3GTQC 1B75A 2L5NA 2WAQD 3RZOC 3S1QC 1ZJWA 1D6KA 3H0GC 1I6VA 5JVHS 4YFXA 2JA5C 4OIQA 4H4KA 2PPBA 4C3IC 1YNJA 3GTPC 4Q4ZA 2E2JC 1K83C 4XLNA 3GTJC 4XSXA 3HOXC 3S1NC 4JXZA 3S16C 3CQZC 5JVGS 4QJVA 2JA8C 4G7OA 1BDFA 4MEYA 3HOVC 2E2HC 3DLLS 1DFUP 1QRTA 4XLPA 1YNNA 2RE8A 3FKIC 2A6HA 3I4NC 1GTSA 2ZJRS 1I50C 3I4MC 1WCMC 4Y52C 4A3LC
chains in the Genus database with same CATH topology
2ZJQS 4WCES 1EXDA 1GTRA 4V194 1O0BA 1UDXA 3PIPS 5GAEW 3PIOS 5GAGW 3W2WB 3J7ZV 4WF9S 1QRUA 4UY88 1B75A 2HZ7A 3X1LB 2ZJPS 1ZJWA 1D6KA 4WFNS 5JVHS 2RD2A 4H4KA 5GAHW 3AIIA 1QRSA 3CF5S 4U67S 1FEUA 5HL7S 1EUQA 4P2BA 4IO9S 3W2VB 4IOCS 4JXZA 1EUYA 5JVGS 1O0CA 4WFBS 5BNZA 1NYLA 3DLLS 1DFUP 1QRTA 5DM6S 4JXXA 2RE8A 4JYZA 5IZNA 1GTSA 4H3SA 2ZJRS 1QTQA 5GADW 5DM7S 4WFAS 4IOAS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZJQ S;  4WCE S;  1EXD A;  1GTR A;  1O0B A;  3PIP S;  5GAE W;  3PIO S;  5GAG W;  3J7Z V;  4WF9 S;  1QRU A;  4UY8 8;  1B75 A;  2HZ7 A;  2ZJP S;  1ZJW A;  1D6K A;  4WFN S;  5JVH S;  2RD2 A;  5GAH W;  3AII A;  1QRS A;  3CF5 S;  4U67 S;  1FEU A;  5HL7 S;  1EUQ A;  4P2B A;  4IO9 S;  4IOC S;  4JXZ A;  1EUY A;  5JVG S;  1O0C A;  4WFB S;  5BNZ A;  1NYL A;  3DLL S;  1DFU P;  1QRT A;  5DM6 S;  4JXX A;  2RE8 A;  4JYZ A;  5IZN A;  1GTS A;  4H3S A;  2ZJR S;  1QTQ A;  5GAD W;  5DM7 S;  4WFA S;  4IOA S; 
#chains in the Genus database with same CATH topology
 2ZJQ S;  3S2D C;  4L69 A;  3HOZ C;  4A3M C;  3M3Y C;  2Z0Y A;  4G7Z A;  4YFN A;  3HKZ D;  2PI8 A;  1TWA C;  1V6Z A;  2A68 A;  3W2W B;  2BE5 A;  4Y7N C;  3GTK C;  1VHK A;  1QRU A;  4X6A C;  2ZJP S;  4KN7 A;  4E8B A;  4WFN S;  3S1R C;  5GAH W;  4XSZ A;  1QRS A;  4LK0 A;  1IW7 A;  5TMF A;  5HL7 S;  1TWF C;  4IO9 S;  1Z85 A;  2PJJ A;  4IOC S;  1Y1V C;  1EUY A;  4A3J C;  2O5I A;  5D4D A;  1I3Q C;  2G6G A;  4MQ9 A;  3WOD A;  1I6H C;  1TWC C;  2R92 C;  4OIN A;  2PNW A;  4JYZ A;  4BBS C;  2PMZ D;  4H3S A;  2VUM C;  3HOY C;  2O5J A;  4OIO A;  5TMC A;  3S2H C;  3GTL C;  4V19 4;  1O0B A;  1UDX A;  2NVY C;  2EGV A;  3LYW A;  5IP7 C;  1Y1W C;  4J3C A;  1HQM A;  2A6E A;  2WB1 D;  3KW2 A;  3J7Z V;  4C3J C;  4UY8 8;  5IYB C;  5IYC C;  3PO2 C;  3RZD C;  1R9T C;  3K7A C;  4GZY A;  1ZYR A;  2CW0 A;  3AII A;  4MEX A;  2CX8 A;  4A3E C;  2R7Z C;  3S14 C;  3S15 C;  4BY7 C;  2E2I C;  4A3G C;  4U67 S;  2NWA A;  1EUQ A;  4A3I C;  2GAE A;  2B63 C;  1O0C A;  4WFB S;  5DM6 S;  4A3K C;  1NXZ A;  2KXY A;  3M4O C;  4KN4 A;  2NVQ C;  2HZ7 A;  2YU9 C;  4IOA S;  4LLG A;  4WFA S;  4YG2 A;  4WCE S;  4LK1 A;  3GTM C;  2KQ1 A;  5FLM C;  3HOW C;  3PIP S;  4C3H C;  5IYD C;  3EQL A;  3PIO S;  5GAG W;  2AE0 X;  5HQH A;  3GTO C;  4QIW D;  3X1L B;  5C44 C;  4OIR A;  1TWG C;  3GTG C;  2RD2 A;  5C4J C;  3S17 C;  2EGW A;  5C4X C;  1VHY A;  4OIP A;  4G7H A;  2Y0S D;  4AYB D;  3CF5 S;  2JA6 C;  1SMY A;  1FEU A;  4P2B A;  3DXJ A;  3W2V B;  4KMU A;  4JK1 A;  3H3V D;  4Q5S A;  1TWH C;  1NYL A;  5BNZ A;  5IP9 C;  2G5D A;  4JXX A;  2L3U A;  5IZN A;  3PO3 C;  2PA8 D;  4BBR C;  5C3E C;  4A3B C;  2R93 C;  2KPU A;  3S1M C;  4BXX C;  1QTQ A;  4YFK A;  5GAD W;  2NVT C;  5DM7 S;  4A3D C;  4BY1 C;  3HOU C;  4A93 C;  1EXD A;  3CZB A;  1GTR A;  4LJZ A;  4A3C C;  5GAE W;  4ZH4 A;  4A3F C;  2NVX C;  2PIC A;  4NOI A;  4WF9 S;  2A69 A;  1SFO C;  2JA7 C;  4C2M C;  3GTQ C;  1B75 A;  2L5N A;  2WAQ D;  3RZO C;  3S1Q C;  1ZJW A;  1D6K A;  3H0G C;  1I6V A;  5JVH S;  4YFX A;  2JA5 C;  4OIQ A;  4H4K A;  2PPB A;  4C3I C;  1YNJ A;  3GTP C;  4Q4Z A;  2E2J C;  1K83 C;  4XLN A;  3GTJ C;  4XSX A;  3HOX C;  3S1N C;  4JXZ A;  3S16 C;  3CQZ C;  5JVG S;  4QJV A;  2JA8 C;  4G7O A;  1BDF A;  4MEY A;  3HOV C;  2E2H C;  3DLL S;  1DFU P;  1QRT A;  4XLP A;  1YNN A;  2RE8 A;  3FKI C;  2A6H A;  3I4N C;  1GTS A;  2ZJR S;  1I50 C;  3I4M C;  1WCM C;  4Y52 C;  4A3L C; 
#chains in the Genus database with same CATH homology
 2ZJQ S;  4WCE S;  1EXD A;  1GTR A;  4V19 4;  1O0B A;  1UDX A;  3PIP S;  5GAE W;  3PIO S;  5GAG W;  3W2W B;  3J7Z V;  4WF9 S;  1QRU A;  4UY8 8;  1B75 A;  2HZ7 A;  3X1L B;  2ZJP S;  1ZJW A;  1D6K A;  4WFN S;  5JVH S;  2RD2 A;  4H4K A;  5GAH W;  3AII A;  1QRS A;  3CF5 S;  4U67 S;  1FEU A;  5HL7 S;  1EUQ A;  4P2B A;  4IO9 S;  3W2V B;  4IOC S;  4JXZ A;  1EUY A;  5JVG S;  1O0C A;  4WFB S;  5BNZ A;  1NYL A;  3DLL S;  1DFU P;  1QRT A;  5DM6 S;  4JXX A;  2RE8 A;  4JYZ A;  5IZN A;  1GTS A;  4H3S A;  2ZJR S;  1QTQ A;  5GAD W;  5DM7 S;  4WFA S;  4IOA S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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