4IOAS

Crystal structure of compound 4e bound to large ribosomal subunit (50s) from deinococcus radiodurans
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
175
structure length
175
Chain Sequence
MELTAKPRTPKQKLDESMIAAVAYNKENNVSFALDRKAFDRAFRQQSTTGLFDITVEGGETFPALVKAVQMDKRKRAPIHVDFYMVTYGEPVEVSVPVHTTGRSQGEVQGGLVDIVVHNLQIVAPGPRRIPQELVVDVTKMNIGDHITAGDIKLPEGCTLAADPELTVVSVLPPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates.
pubmed doi rcsb
molecule tags Ribosome/ribosome inhibitor
molecule keywords 23S ribosomal RNA
total genus 25
structure length 175
sequence length 175
ec nomenclature
pdb deposition date 2013-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 4ioaS01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 4ioaS02
5GAGW 1GTSA 4H3SA 1O0BA 5GAHW 1QRUA 4JXZA 1QRSA 1NYLA 2ZJPS 1EUQA 4WFBS 4IOAS 3PIOS 1FEUA 4U67S 5IZNA 3J7ZV 4JXXA 5BNZA 4WF9S 5GAEW 5HL7S 3PIPS 2ZJQS 4IOCS 2RD2A 1EUYA 1GTRA 2ZJRS 2RE8A 4IO9S 4UY88 5DM6S 1B75A 3DLLS 1O0CA 5JVGS 5DM7S 1ZJWA 3AIIA 1D6KA 2HZ7A 5GADW 4WFAS 4JYZA 1QRTA 4WCES 3CF5S 1DFUP 4P2BA 1QTQA 1EXDA 5JVHS 4WFNS
chains in the Genus database with same CATH superfamily
4LJZA 3HOVC 2JA7C 5GAHW 2EGWA 3FKIC 3S1MC 1NYLA 2O5JA 1YNJA 3S17C 4E8BA 2NWAA 3EQLA 3KW2A 4IOAS 3PIOS 4KMUA 3GTJC 1Z85A 5HQHA 4C3IC 3J7ZV 2G5DA 2NVTC 2PI8A 1I6VA 4L69A 2JA6C 5HL7S 2ZJQS 2RD2A 4A3IC 4JK1A 3HOZC 2RE8A 1WCMC 4BBSC 4UY88 3X1LB 2YU9C 3DLLS 4XLNA 1O0CA 5JVGS 1SMYA 2A69A 5C3EC 1TWGC 2NVXC 4A3EC 3AIIA 2GAEA 3S1NC 1IW7A 3GTKC 4MQ9A 4P2BA 4J3CA 1NXZA 5JVHS 1EUQA 4WFNS 4C2MC 3H0GC 5IYBC 2R92C 3GTPC 2KPUA 1QRUA 1V6ZA 3S2HC 1QRSA 4OINA 1SFOC 4WFBS 3HKZD 2WB1D 4ZH4A 5C4XC 4KN4A 5TMCA 2JA8C 2NVYC 2L3UA 4YG2A 1I50C 4YFNA 4OIPA 4YFKA 3M4OC 4XSZA 4BXXC 5IYDC 4A3CC 4WF9S 3GTOC 2E2HC 4NOIA 5IP7C 1VHKA 3DXJA 2NVQC 3RZOC 4IO9S 4C3JC 5DM6S 1B75A 5IYCC 4QJVA 1ZJWA 2PNWA 1ZYRA 1D6KA 1BDFA 4A3DC 5GADW 4WFAS 1TWCC 4G7ZA 3HOUC 4BY7C 2PJJA 4V194 4WCES 1DFUP 2E2JC 3GTQC 1QTQA 1Y1WC 1EXDA 2BE5A 4A3JC 5GAGW 2CW0A 2Z0YA 1O0BA 3I4NC 3S1QC 2O5IA 5IP9C 1K83C 2ZJPS 2AE0X 3S15C 1HQMA 2A6EA 1FEUA 2Y0SD 4U67S 2G6GA 4OIQA 3H3VD 2PICA 4A3GC 5BNZA 4LK0A 3W2WB 5GAEW 1VHYA 4IOCS 4QIWD 3S16C 1I3QC 2PA8D 4G7OA 2PMZD 4MEYA 4G7HA 2ZJRS 4LK1A 1Y1VC 1R9TC 5FLMC 4YFXA 3CQZC 4Y52C 2A6HA 2HZ7A 4JYZA 4A3MC 2PPBA 5C4JC 4OIRA 2R93C 1UDXA 2R7ZC 3K7AC 2A68A 4AYBD 1YNNA 3W2VB 2CX8A 1GTSA 4H3SA 4Y7NC 3S1RC 4MEXA 4A3KC 3RZDC 4A3LC 3S14C 4JXZA 4BY1C 2L5NA 4A3BC 4XLPA 1I6HC 5D4DA 3HOYC 4Q5SA 4BBRC 1TWAC 4XSXA 5TMFA 4H4KA 2EGVA 5IZNA 4JXXA 2WAQD 3WODA 4A3FC 3HOWC 4X6AC 3PO2C 3PIPS 4OIOA 4A93C 1EUYA 1GTRA 3GTLC 3HOXC 4Q4ZA 5C44C 1TWFC 3GTMC 3GTGC 5DM7S 3PO3C 2JA5C 3S2DC 4GZYA 2VUMC 3CZBA 3LYWA 1QRTA 2KXYA 3I4MC 2KQ1A 4C3HC 3CF5S 1TWHC 4KN7A 4LLGA 3M3YC 2B63C 2E2IC
chains in the Genus database with same CATH topology
5GAGW 3W2VB 1GTSA 4H3SA 1O0BA 5GAHW 1QRUA 4JXZA 1QRSA 1NYLA 2ZJPS 1EUQA 4WFBS 4IOAS 3PIOS 1FEUA 4U67S 4H4KA 5IZNA 3J7ZV 4JXXA 5BNZA 4WF9S 5GAEW 3W2WB 5HL7S 3PIPS 2ZJQS 4IOCS 2RD2A 1EUYA 1GTRA 2ZJRS 2RE8A 4IO9S 4UY88 5DM6S 3X1LB 3DLLS 1B75A 1O0CA 5JVGS 5DM7S 1ZJWA 3AIIA 1D6KA 2HZ7A 5GADW 4WFAS 4JYZA 1QRTA 4V194 4WCES 1UDXA 3CF5S 1DFUP 4P2BA 1QTQA 1EXDA 5JVHS 4WFNS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5GAG W;  1GTS A;  4H3S A;  1O0B A;  5GAH W;  1QRU A;  4JXZ A;  1QRS A;  1NYL A;  2ZJP S;  1EUQ A;  4WFB S;  4IOA S;  3PIO S;  1FEU A;  4U67 S;  5IZN A;  3J7Z V;  4JXX A;  5BNZ A;  4WF9 S;  5GAE W;  5HL7 S;  3PIP S;  2ZJQ S;  4IOC S;  2RD2 A;  1EUY A;  1GTR A;  2ZJR S;  2RE8 A;  4IO9 S;  4UY8 8;  5DM6 S;  1B75 A;  3DLL S;  1O0C A;  5JVG S;  5DM7 S;  1ZJW A;  3AII A;  1D6K A;  2HZ7 A;  5GAD W;  4WFA S;  4JYZ A;  1QRT A;  4WCE S;  3CF5 S;  1DFU P;  4P2B A;  1QTQ A;  1EXD A;  5JVH S;  4WFN S; 
#chains in the Genus database with same CATH topology
 4LJZ A;  3HOV C;  2JA7 C;  5GAH W;  2EGW A;  3FKI C;  3S1M C;  1NYL A;  2O5J A;  1YNJ A;  3S17 C;  4E8B A;  2NWA A;  3EQL A;  3KW2 A;  4IOA S;  3PIO S;  4KMU A;  3GTJ C;  1Z85 A;  5HQH A;  4C3I C;  3J7Z V;  2G5D A;  2NVT C;  2PI8 A;  1I6V A;  4L69 A;  2JA6 C;  5HL7 S;  2ZJQ S;  2RD2 A;  4A3I C;  4JK1 A;  3HOZ C;  2RE8 A;  1WCM C;  4BBS C;  4UY8 8;  3X1L B;  2YU9 C;  3DLL S;  4XLN A;  1O0C A;  5JVG S;  1SMY A;  2A69 A;  5C3E C;  1TWG C;  2NVX C;  4A3E C;  3AII A;  2GAE A;  3S1N C;  1IW7 A;  3GTK C;  4MQ9 A;  4P2B A;  4J3C A;  1NXZ A;  5JVH S;  1EUQ A;  4WFN S;  4C2M C;  3H0G C;  5IYB C;  2R92 C;  3GTP C;  2KPU A;  1QRU A;  1V6Z A;  3S2H C;  1QRS A;  4OIN A;  1SFO C;  4WFB S;  3HKZ D;  2WB1 D;  4ZH4 A;  5C4X C;  4KN4 A;  5TMC A;  2JA8 C;  2NVY C;  2L3U A;  4YG2 A;  1I50 C;  4YFN A;  4OIP A;  4YFK A;  3M4O C;  4XSZ A;  4BXX C;  5IYD C;  4A3C C;  4WF9 S;  3GTO C;  2E2H C;  4NOI A;  5IP7 C;  1VHK A;  3DXJ A;  2NVQ C;  3RZO C;  4IO9 S;  4C3J C;  5DM6 S;  1B75 A;  5IYC C;  4QJV A;  1ZJW A;  2PNW A;  1ZYR A;  1D6K A;  1BDF A;  4A3D C;  5GAD W;  4WFA S;  1TWC C;  4G7Z A;  3HOU C;  4BY7 C;  2PJJ A;  4V19 4;  4WCE S;  1DFU P;  2E2J C;  3GTQ C;  1QTQ A;  1Y1W C;  1EXD A;  2BE5 A;  4A3J C;  5GAG W;  2CW0 A;  2Z0Y A;  1O0B A;  3I4N C;  3S1Q C;  2O5I A;  5IP9 C;  1K83 C;  2ZJP S;  2AE0 X;  3S15 C;  1HQM A;  2A6E A;  1FEU A;  2Y0S D;  4U67 S;  2G6G A;  4OIQ A;  3H3V D;  2PIC A;  4A3G C;  5BNZ A;  4LK0 A;  3W2W B;  5GAE W;  1VHY A;  4IOC S;  4QIW D;  3S16 C;  1I3Q C;  2PA8 D;  4G7O A;  2PMZ D;  4MEY A;  4G7H A;  2ZJR S;  4LK1 A;  1Y1V C;  1R9T C;  5FLM C;  4YFX A;  3CQZ C;  4Y52 C;  2A6H A;  2HZ7 A;  4JYZ A;  4A3M C;  2PPB A;  5C4J C;  4OIR A;  2R93 C;  1UDX A;  2R7Z C;  3K7A C;  2A68 A;  4AYB D;  1YNN A;  3W2V B;  2CX8 A;  1GTS A;  4H3S A;  4Y7N C;  3S1R C;  4MEX A;  4A3K C;  3RZD C;  4A3L C;  3S14 C;  4JXZ A;  4BY1 C;  2L5N A;  4A3B C;  4XLP A;  1I6H C;  5D4D A;  3HOY C;  4Q5S A;  4BBR C;  1TWA C;  4XSX A;  5TMF A;  4H4K A;  2EGV A;  5IZN A;  4JXX A;  2WAQ D;  3WOD A;  4A3F C;  3HOW C;  4X6A C;  3PO2 C;  3PIP S;  4OIO A;  4A93 C;  1EUY A;  1GTR A;  3GTL C;  3HOX C;  4Q4Z A;  5C44 C;  1TWF C;  3GTM C;  3GTG C;  5DM7 S;  3PO3 C;  2JA5 C;  3S2D C;  4GZY A;  2VUM C;  3CZB A;  3LYW A;  1QRT A;  2KXY A;  3I4M C;  2KQ1 A;  4C3H C;  3CF5 S;  1TWH C;  4KN7 A;  4LLG A;  3M3Y C;  2B63 C;  2E2I C; 
#chains in the Genus database with same CATH homology
 5GAG W;  3W2V B;  1GTS A;  4H3S A;  1O0B A;  5GAH W;  1QRU A;  4JXZ A;  1QRS A;  1NYL A;  2ZJP S;  1EUQ A;  4WFB S;  4IOA S;  3PIO S;  1FEU A;  4U67 S;  4H4K A;  5IZN A;  3J7Z V;  4JXX A;  5BNZ A;  4WF9 S;  5GAE W;  3W2W B;  5HL7 S;  3PIP S;  2ZJQ S;  4IOC S;  2RD2 A;  1EUY A;  1GTR A;  2ZJR S;  2RE8 A;  4IO9 S;  4UY8 8;  5DM6 S;  3X1L B;  3DLL S;  1B75 A;  1O0C A;  5JVG S;  5DM7 S;  1ZJW A;  3AII A;  1D6K A;  2HZ7 A;  5GAD W;  4WFA S;  4JYZ A;  1QRT A;  4V19 4;  4WCE S;  1UDX A;  3CF5 S;  1DFU P;  4P2B A;  1QTQ A;  1EXD A;  5JVH S;  4WFN S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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