4IOCS

Crystal structure of compound 4f bound to large ribosomal subunit (50s) from deinococcus radiodurans
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
175
structure length
175
Chain Sequence
MELTAKPRTPKQKLDESMIAAVAYNKENNVSFALDRKAFDRAFRQQSTTGLFDITVEGGETFPALVKAVQMDKRKRAPIHVDFYMVTYGEPVEVSVPVHTTGRSQGEVQGGLVDIVVHNLQIVAPGPRRIPQELVVDVTKMNIGDHITAGDIKLPEGCTLAADPELTVVSVLPPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Ribosome/ribosome inhibitor
publication title Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates.
pubmed doi rcsb
molecule keywords 23S ribosomal RNA
total genus 21
structure length 175
sequence length 175
ec nomenclature
pdb deposition date 2013-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 4iocS01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 4iocS02
4WCES 4JXZA 2HZ7A 4WFAS 4UY88 5JVHS 3CF5S 1EXDA 5DM6S 1ZJWA 3J7ZV 4IOAS 1EUQA 2RE8A 3PIOS 4JXXA 5DM7S 1QRTA 5BNZA 5IZNA 4P2BA 1O0BA 1NYLA 4H3SA 4WFBS 4U67S 1QRUA 3PIPS 1D6KA 5GAEW 4WFNS 1O0CA 5GAGW 1QTQA 2RD2A 3DLLS 5HL7S 1GTSA 1GTRA 1FEUA 1EUYA 4WF9S 4IOCS 1QRSA 4JYZA 5GAHW 2ZJRS 4IO9S 2ZJPS 3AIIA 1DFUP 5JVGS 1B75A 5GADW 2ZJQS
chains in the Genus database with same CATH superfamily
4WCES 2L3UA 2KXYA 2HZ7A 4UY88 4YG2A 4C3IC 2E2JC 3CF5S 3CZBA 1EXDA 2A6EA 5D4DA 5C3EC 3W2WB 3S17C 5C4XC 3J7ZV 3HOZC 5IYCC 4A3CC 4XLNA 5BNZA 3M3YC 1TWCC 2PJJA 1O0BA 4QIWD 4A3EC 4LK1A 4U67S 2PA8D 4A3DC 3PIPS 1D6KA 5GAEW 1QTQA 4Q4ZA 3K7AC 3RZDC 4YFNA 1GTRA 1TWFC 2B63C 2R92C 4MEXA 4MQ9A 3S1NC 3S2DC 2G5DA 4A93C 3HOXC 2O5IA 5GAHW 3S16C 1Y1WC 1VHYA 2PICA 3HKZD 3M4OC 2PNWA 3W2VB 4LJZA 4Q5SA 2EGVA 3S1RC 2PPBA 3I4MC 2E2HC 5DM6S 3H0GC 4J3CA 2NWAA 1BDFA 2CW0A 4OIQA 2GAEA 1EUQA 4XSZA 2RE8A 1UDXA 2R7ZC 1VHKA 1Z85A 3X1LB 4JK1A 4H4KA 4XLPA 1TWGC 2PMZD 4G7HA 1YNJA 3LYWA 2JA5C 3GTOC 2AE0X 1I6HC 1QRUA 4A3FC 3GTMC 3HOVC 4BBRC 3CQZC 4E8BA 2CX8A 3DLLS 1FEUA 1GTSA 1EUYA 4A3MC 4BY7C 4OIOA 2JA8C 2ZJRS 3AIIA 1TWHC 3S15C 2KPUA 5TMCA 4A3GC 5GADW 4LK0A 2ZJQS 5IP7C 3GTLC 3HOUC 3I4NC 4MEYA 1I6VA 4WFAS 5FLMC 5JVHS 3GTQC 2WAQD 1ZJWA 1NXZA 3GTJC 4KMUA 4A3IC 4A3BC 4GZYA 3S1QC 3PIOS 5DM7S 4YFXA 5TMFA 3EQLA 4YFKA 3RZOC 3KW2A 4P2BA 4OINA 3WODA 4OIPA 3S2HC 1NYLA 3S1MC 4G7ZA 3PO2C 2Z0YA 2A68A 4V194 3HOWC 2L5NA 2KQ1A 1TWAC 3FKIC 2Y0SD 3HOYC 5HL7S 2JA7C 3DXJA 4WF9S 4A3KC 4IOCS 3H3VD 4C3JC 2EGWA 4IO9S 2E2IC 2VUMC 5HQHA 2BE5A 3S14C 3PO3C 2G6GA 5C44C 5JVGS 2PI8A 2JA6C 4X6AC 3GTGC 4JXZA 4BXXC 1Y1VC 1K83C 4A3LC 4C2MC 4C3HC 4XSXA 3GTPC 4IOAS 1IW7A 2NVXC 4G7OA 5IYDC 4AYBD 4JXXA 1SFOC 2O5JA 1QRTA 4BY1C 4NOIA 5IZNA 4KN4A 1ZYRA 4H3SA 4ZH4A 4WFBS 2A69A 4L69A 4KN7A 4Y7NC 2R93C 4QJVA 4WFNS 1O0CA 5GAGW 1R9TC 5C4JC 1V6ZA 1I50C 1WCMC 2RD2A 5IYBC 1SMYA 1HQMA 1I3QC 2A6HA 2YU9C 2WB1D 1QRSA 4JYZA 4LLGA 4Y52C 2NVQC 5IP9C 2ZJPS 1YNNA 1DFUP 3GTKC 2NVYC 4A3JC 4BBSC 1B75A 2NVTC 4OIRA
chains in the Genus database with same CATH topology
3W2VB 4WCES 4JXZA 2HZ7A 4WFAS 4UY88 5JVHS 3CF5S 1EXDA 5DM6S 3W2WB 1ZJWA 3J7ZV 4IOAS 1EUQA 2RE8A 1UDXA 3PIOS 4JXXA 5DM7S 1QRTA 3X1LB 5BNZA 4H4KA 5IZNA 4P2BA 1O0BA 1NYLA 4H3SA 4WFBS 4U67S 1QRUA 3PIPS 1D6KA 4V194 5GAEW 4WFNS 1O0CA 5GAGW 1QTQA 2RD2A 3DLLS 5HL7S 1GTSA 1GTRA 1FEUA 1EUYA 4WF9S 4IOCS 1QRSA 4JYZA 5GAHW 2ZJRS 4IO9S 2ZJPS 3AIIA 1DFUP 5JVGS 1B75A 5GADW 2ZJQS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4WCE S;  4JXZ A;  2HZ7 A;  4WFA S;  4UY8 8;  5JVH S;  3CF5 S;  1EXD A;  5DM6 S;  1ZJW A;  3J7Z V;  4IOA S;  1EUQ A;  2RE8 A;  3PIO S;  4JXX A;  5DM7 S;  1QRT A;  5BNZ A;  5IZN A;  4P2B A;  1O0B A;  1NYL A;  4H3S A;  4WFB S;  4U67 S;  1QRU A;  3PIP S;  1D6K A;  5GAE W;  4WFN S;  1O0C A;  5GAG W;  1QTQ A;  2RD2 A;  3DLL S;  5HL7 S;  1GTS A;  1GTR A;  1FEU A;  1EUY A;  4WF9 S;  4IOC S;  1QRS A;  4JYZ A;  5GAH W;  2ZJR S;  4IO9 S;  2ZJP S;  3AII A;  1DFU P;  5JVG S;  1B75 A;  5GAD W;  2ZJQ S; 
#chains in the Genus database with same CATH topology
 4WCE S;  2L3U A;  2KXY A;  2HZ7 A;  4UY8 8;  4YG2 A;  4C3I C;  2E2J C;  3CF5 S;  3CZB A;  1EXD A;  2A6E A;  5D4D A;  5C3E C;  3W2W B;  3S17 C;  5C4X C;  3J7Z V;  3HOZ C;  5IYC C;  4A3C C;  4XLN A;  5BNZ A;  3M3Y C;  1TWC C;  2PJJ A;  1O0B A;  4QIW D;  4A3E C;  4LK1 A;  4U67 S;  2PA8 D;  4A3D C;  3PIP S;  1D6K A;  5GAE W;  1QTQ A;  4Q4Z A;  3K7A C;  3RZD C;  4YFN A;  1GTR A;  1TWF C;  2B63 C;  2R92 C;  4MEX A;  4MQ9 A;  3S1N C;  3S2D C;  2G5D A;  4A93 C;  3HOX C;  2O5I A;  5GAH W;  3S16 C;  1Y1W C;  1VHY A;  2PIC A;  3HKZ D;  3M4O C;  2PNW A;  3W2V B;  4LJZ A;  4Q5S A;  2EGV A;  3S1R C;  2PPB A;  3I4M C;  2E2H C;  5DM6 S;  3H0G C;  4J3C A;  2NWA A;  1BDF A;  2CW0 A;  4OIQ A;  2GAE A;  1EUQ A;  4XSZ A;  2RE8 A;  1UDX A;  2R7Z C;  1VHK A;  1Z85 A;  3X1L B;  4JK1 A;  4H4K A;  4XLP A;  1TWG C;  2PMZ D;  4G7H A;  1YNJ A;  3LYW A;  2JA5 C;  3GTO C;  2AE0 X;  1I6H C;  1QRU A;  4A3F C;  3GTM C;  3HOV C;  4BBR C;  3CQZ C;  4E8B A;  2CX8 A;  3DLL S;  1FEU A;  1GTS A;  1EUY A;  4A3M C;  4BY7 C;  4OIO A;  2JA8 C;  2ZJR S;  3AII A;  1TWH C;  3S15 C;  2KPU A;  5TMC A;  4A3G C;  5GAD W;  4LK0 A;  2ZJQ S;  5IP7 C;  3GTL C;  3HOU C;  3I4N C;  4MEY A;  1I6V A;  4WFA S;  5FLM C;  5JVH S;  3GTQ C;  2WAQ D;  1ZJW A;  1NXZ A;  3GTJ C;  4KMU A;  4A3I C;  4A3B C;  4GZY A;  3S1Q C;  3PIO S;  5DM7 S;  4YFX A;  5TMF A;  3EQL A;  4YFK A;  3RZO C;  3KW2 A;  4P2B A;  4OIN A;  3WOD A;  4OIP A;  3S2H C;  1NYL A;  3S1M C;  4G7Z A;  3PO2 C;  2Z0Y A;  2A68 A;  4V19 4;  3HOW C;  2L5N A;  2KQ1 A;  1TWA C;  3FKI C;  2Y0S D;  3HOY C;  5HL7 S;  2JA7 C;  3DXJ A;  4WF9 S;  4A3K C;  4IOC S;  3H3V D;  4C3J C;  2EGW A;  4IO9 S;  2E2I C;  2VUM C;  5HQH A;  2BE5 A;  3S14 C;  3PO3 C;  2G6G A;  5C44 C;  5JVG S;  2PI8 A;  2JA6 C;  4X6A C;  3GTG C;  4JXZ A;  4BXX C;  1Y1V C;  1K83 C;  4A3L C;  4C2M C;  4C3H C;  4XSX A;  3GTP C;  4IOA S;  1IW7 A;  2NVX C;  4G7O A;  5IYD C;  4AYB D;  4JXX A;  1SFO C;  2O5J A;  1QRT A;  4BY1 C;  4NOI A;  5IZN A;  4KN4 A;  1ZYR A;  4H3S A;  4ZH4 A;  4WFB S;  2A69 A;  4L69 A;  4KN7 A;  4Y7N C;  2R93 C;  4QJV A;  4WFN S;  1O0C A;  5GAG W;  1R9T C;  5C4J C;  1V6Z A;  1I50 C;  1WCM C;  2RD2 A;  5IYB C;  1SMY A;  1HQM A;  1I3Q C;  2A6H A;  2YU9 C;  2WB1 D;  1QRS A;  4JYZ A;  4LLG A;  4Y52 C;  2NVQ C;  5IP9 C;  2ZJP S;  1YNN A;  1DFU P;  3GTK C;  2NVY C;  4A3J C;  4BBS C;  1B75 A;  2NVT C;  4OIR A; 
#chains in the Genus database with same CATH homology
 3W2V B;  4WCE S;  4JXZ A;  2HZ7 A;  4WFA S;  4UY8 8;  5JVH S;  3CF5 S;  1EXD A;  5DM6 S;  3W2W B;  1ZJW A;  3J7Z V;  4IOA S;  1EUQ A;  2RE8 A;  1UDX A;  3PIO S;  4JXX A;  5DM7 S;  1QRT A;  3X1L B;  5BNZ A;  4H4K A;  5IZN A;  4P2B A;  1O0B A;  1NYL A;  4H3S A;  4WFB S;  4U67 S;  1QRU A;  3PIP S;  1D6K A;  4V19 4;  5GAE W;  4WFN S;  1O0C A;  5GAG W;  1QTQ A;  2RD2 A;  3DLL S;  5HL7 S;  1GTS A;  1GTR A;  1FEU A;  1EUY A;  4WF9 S;  4IOC S;  1QRS A;  4JYZ A;  5GAH W;  2ZJR S;  4IO9 S;  2ZJP S;  3AII A;  1DFU P;  5JVG S;  1B75 A;  5GAD W;  2ZJQ S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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