4IOCS

Crystal structure of compound 4f bound to large ribosomal subunit (50s) from deinococcus radiodurans
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
175
structure length
175
Chain Sequence
MELTAKPRTPKQKLDESMIAAVAYNKENNVSFALDRKAFDRAFRQQSTTGLFDITVEGGETFPALVKAVQMDKRKRAPIHVDFYMVTYGEPVEVSVPVHTTGRSQGEVQGGLVDIVVHNLQIVAPGPRRIPQELVVDVTKMNIGDHITAGDIKLPEGCTLAADPELTVVSVLPPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates.
pubmed doi rcsb
molecule tags Ribosome/ribosome inhibitor
molecule keywords 23S ribosomal RNA
total genus 21
structure length 175
sequence length 175
ec nomenclature
pdb deposition date 2013-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 4iocS01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 4iocS02
1FEUA 5DM7S 4P2BA 5GAEW 1QRUA 4JXXA 2ZJRS 5JVHS 4WFAS 4H3SA 4JXZA 4WFNS 5JVGS 1EUQA 1GTRA 5BNZA 1EXDA 2ZJPS 3J7ZV 2RD2A 4IOCS 1D6KA 4WF9S 1QRTA 1NYLA 3PIPS 4UY88 4WFBS 1QTQA 3AIIA 1QRSA 3DLLS 2RE8A 4JYZA 5HL7S 5IZNA 4WCES 1O0BA 5GAGW 1EUYA 1B75A 5GADW 2HZ7A 1DFUP 5GAHW 4IOAS 5DM6S 3PIOS 1GTSA 1ZJWA 1O0CA 2ZJQS 4IO9S 3CF5S 4U67S
chains in the Genus database with same CATH superfamily
5IP7C 3S17C 5GAEW 3HOVC 4XSXA 2NWAA 5IYBC 1QRUA 4OIRA 3HOZC 4JK1A 3GTKC 3CZBA 2R7ZC 4QIWD 1Y1WC 4H3SA 3GTLC 3HOWC 1GTRA 3RZDC 4IOCS 3J7ZV 2BE5A 3I4MC 4XSZA 2JA6C 4BXXC 4LLGA 4UY88 2WB1D 4H4KA 1YNNA 4MEXA 2G5DA 1UDXA 2A68A 3RZOC 1QRSA 1Z85A 2PA8D 2R93C 4A3KC 4KN4A 1DFUP 4AYBD 2A6EA 5DM6S 4XLNA 1ZJWA 5C3EC 2WAQD 5TMCA 4A93C 4IO9S 1TWAC 3CF5S 4Y52C 1FEUA 5DM7S 4OINA 2A69A 4YFKA 2CW0A 4A3CC 1IW7A 2NVYC 4KMUA 3K7AC 5C44C 1TWFC 3S1NC 2ZJRS 4BBSC 2O5IA 5JVHS 2CX8A 4A3MC 4KN7A 4ZH4A 1YNJA 5JVGS 1EUQA 4Q4ZA 4BY7C 5IYDC 1D6KA 2RD2A 3I4NC 3S16C 3GTOC 2NVQC 3H3VD 4OIOA 1NYLA 2R92C 3FKIC 1QTQA 4LK1A 4MEYA 2L5NA 4Q5SA 2PJJA 4WCES 1O0BA 1BDFA 2PNWA 3S1RC 2NVXC 3S14C 4A3FC 1V6ZA 4IOAS 3EQLA 2PICA 3GTMC 2NVTC 1I6HC 1TWGC 3GTPC 3GTQC 4YFNA 2G6GA 4JXXA 2B63C 3HOYC 4A3LC 3W2WB 4JXZA 4G7HA 2Z0YA 4L69A 4Y7NC 2KPUA 2EGWA 4YG2A 1EXDA 4XLPA 2E2HC 2KQ1A 4WF9S 2YU9C 4C3JC 4G7OA 4LK0A 5HQHA 2E2JC 3CQZC 2EGVA 4WFBS 3AIIA 1I3QC 4LJZA 1VHYA 2RE8A 4MQ9A 5IYCC 5HL7S 5FLMC 1SFOC 3S1MC 4V194 4A3IC 1HQMA 3HOXC 1EUYA 4A3DC 2Y0SD 1B75A 3GTJC 3KW2A 4QJVA 4G7ZA 2L3UA 3PIOS 5TMFA 1SMYA 1O0CA 2JA8C 3W2VB 4OIPA 4J3CA 2O5JA 5IP9C 1VHKA 2AE0X 4X6AC 4U67S 2A6HA 3S2HC 3PO2C 4A3JC 4P2BA 3WODA 4YFXA 4C3IC 3X1LB 3DXJA 4C3HC 1WCMC 1ZYRA 3HKZD 4WFAS 3PO3C 2E2IC 3S15C 4WFNS 2PPBA 4BBRC 2JA5C 2KXYA 4E8BA 5BNZA 4GZYA 2ZJPS 1Y1VC 4NOIA 2PMZD 1QRTA 1TWCC 3PIPS 1NXZA 4A3GC 4OIQA 2PI8A 3DLLS 1R9TC 2VUMC 3S1QC 4JYZA 1I6VA 5IZNA 3GTGC 3S2DC 5GAGW 4C2MC 1K83C 5GADW 2HZ7A 3HOUC 5GAHW 1I50C 2GAEA 2JA7C 4A3EC 3M4OC 1GTSA 5C4XC 5D4DA 3H0GC 5C4JC 4BY1C 3M3YC 2ZJQS 3LYWA 4A3BC 1TWHC
chains in the Genus database with same CATH topology
1FEUA 5DM7S 4P2BA 5GAEW 1QRUA 3X1LB 4JXXA 2ZJRS 5JVHS 4WFAS 3W2WB 4H3SA 4JXZA 4WFNS 5JVGS 1EUQA 1GTRA 5BNZA 1EXDA 2ZJPS 3J7ZV 2RD2A 4IOCS 1D6KA 4WF9S 1QRTA 1NYLA 3PIPS 4UY88 4H4KA 1UDXA 4WFBS 3AIIA 1QRSA 3DLLS 1QTQA 2RE8A 4JYZA 5HL7S 5IZNA 4WCES 1O0BA 4V194 5GAGW 1EUYA 1B75A 5GADW 2HZ7A 1DFUP 5GAHW 4IOAS 5DM6S 3PIOS 1GTSA 1ZJWA 1O0CA 3W2VB 2ZJQS 4IO9S 3CF5S 4U67S
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FEU A;  5DM7 S;  4P2B A;  5GAE W;  1QRU A;  4JXX A;  2ZJR S;  5JVH S;  4WFA S;  4H3S A;  4JXZ A;  4WFN S;  5JVG S;  1EUQ A;  1GTR A;  5BNZ A;  1EXD A;  2ZJP S;  3J7Z V;  2RD2 A;  4IOC S;  1D6K A;  4WF9 S;  1QRT A;  1NYL A;  3PIP S;  4UY8 8;  4WFB S;  1QTQ A;  3AII A;  1QRS A;  3DLL S;  2RE8 A;  4JYZ A;  5HL7 S;  5IZN A;  4WCE S;  1O0B A;  5GAG W;  1EUY A;  1B75 A;  5GAD W;  2HZ7 A;  1DFU P;  5GAH W;  4IOA S;  5DM6 S;  3PIO S;  1GTS A;  1ZJW A;  1O0C A;  2ZJQ S;  4IO9 S;  3CF5 S;  4U67 S; 
#chains in the Genus database with same CATH topology
 5IP7 C;  3S17 C;  5GAE W;  3HOV C;  4XSX A;  2NWA A;  5IYB C;  1QRU A;  4OIR A;  3HOZ C;  4JK1 A;  3GTK C;  3CZB A;  2R7Z C;  4QIW D;  1Y1W C;  4H3S A;  3GTL C;  3HOW C;  1GTR A;  3RZD C;  4IOC S;  3J7Z V;  2BE5 A;  3I4M C;  4XSZ A;  2JA6 C;  4BXX C;  4LLG A;  4UY8 8;  2WB1 D;  4H4K A;  1YNN A;  4MEX A;  2G5D A;  1UDX A;  2A68 A;  3RZO C;  1QRS A;  1Z85 A;  2PA8 D;  2R93 C;  4A3K C;  4KN4 A;  1DFU P;  4AYB D;  2A6E A;  5DM6 S;  4XLN A;  1ZJW A;  5C3E C;  2WAQ D;  5TMC A;  4A93 C;  4IO9 S;  1TWA C;  3CF5 S;  4Y52 C;  1FEU A;  5DM7 S;  4OIN A;  2A69 A;  4YFK A;  2CW0 A;  4A3C C;  1IW7 A;  2NVY C;  4KMU A;  3K7A C;  5C44 C;  1TWF C;  3S1N C;  2ZJR S;  4BBS C;  2O5I A;  5JVH S;  2CX8 A;  4A3M C;  4KN7 A;  4ZH4 A;  1YNJ A;  5JVG S;  1EUQ A;  4Q4Z A;  4BY7 C;  5IYD C;  1D6K A;  2RD2 A;  3I4N C;  3S16 C;  3GTO C;  2NVQ C;  3H3V D;  4OIO A;  1NYL A;  2R92 C;  3FKI C;  1QTQ A;  4LK1 A;  4MEY A;  2L5N A;  4Q5S A;  2PJJ A;  4WCE S;  1O0B A;  1BDF A;  2PNW A;  3S1R C;  2NVX C;  3S14 C;  4A3F C;  1V6Z A;  4IOA S;  3EQL A;  2PIC A;  3GTM C;  2NVT C;  1I6H C;  1TWG C;  3GTP C;  3GTQ C;  4YFN A;  2G6G A;  4JXX A;  2B63 C;  3HOY C;  4A3L C;  3W2W B;  4JXZ A;  4G7H A;  2Z0Y A;  4L69 A;  4Y7N C;  2KPU A;  2EGW A;  4YG2 A;  1EXD A;  4XLP A;  2E2H C;  2KQ1 A;  4WF9 S;  2YU9 C;  4C3J C;  4G7O A;  4LK0 A;  5HQH A;  2E2J C;  3CQZ C;  2EGV A;  4WFB S;  3AII A;  1I3Q C;  4LJZ A;  1VHY A;  2RE8 A;  4MQ9 A;  5IYC C;  5HL7 S;  5FLM C;  1SFO C;  3S1M C;  4V19 4;  4A3I C;  1HQM A;  3HOX C;  1EUY A;  4A3D C;  2Y0S D;  1B75 A;  3GTJ C;  3KW2 A;  4QJV A;  4G7Z A;  2L3U A;  3PIO S;  5TMF A;  1SMY A;  1O0C A;  2JA8 C;  3W2V B;  4OIP A;  4J3C A;  2O5J A;  5IP9 C;  1VHK A;  2AE0 X;  4X6A C;  4U67 S;  2A6H A;  3S2H C;  3PO2 C;  4A3J C;  4P2B A;  3WOD A;  4YFX A;  4C3I C;  3X1L B;  3DXJ A;  4C3H C;  1WCM C;  1ZYR A;  3HKZ D;  4WFA S;  3PO3 C;  2E2I C;  3S15 C;  4WFN S;  2PPB A;  4BBR C;  2JA5 C;  2KXY A;  4E8B A;  5BNZ A;  4GZY A;  2ZJP S;  1Y1V C;  4NOI A;  2PMZ D;  1QRT A;  1TWC C;  3PIP S;  1NXZ A;  4A3G C;  4OIQ A;  2PI8 A;  3DLL S;  1R9T C;  2VUM C;  3S1Q C;  4JYZ A;  1I6V A;  5IZN A;  3GTG C;  3S2D C;  5GAG W;  4C2M C;  1K83 C;  5GAD W;  2HZ7 A;  3HOU C;  5GAH W;  1I50 C;  2GAE A;  2JA7 C;  4A3E C;  3M4O C;  1GTS A;  5C4X C;  5D4D A;  3H0G C;  5C4J C;  4BY1 C;  3M3Y C;  2ZJQ S;  3LYW A;  4A3B C;  1TWH C; 
#chains in the Genus database with same CATH homology
 1FEU A;  5DM7 S;  4P2B A;  5GAE W;  1QRU A;  3X1L B;  4JXX A;  2ZJR S;  5JVH S;  4WFA S;  3W2W B;  4H3S A;  4JXZ A;  4WFN S;  5JVG S;  1EUQ A;  1GTR A;  5BNZ A;  1EXD A;  2ZJP S;  3J7Z V;  2RD2 A;  4IOC S;  1D6K A;  4WF9 S;  1QRT A;  1NYL A;  3PIP S;  4UY8 8;  4H4K A;  1UDX A;  4WFB S;  3AII A;  1QRS A;  3DLL S;  1QTQ A;  2RE8 A;  4JYZ A;  5HL7 S;  5IZN A;  4WCE S;  1O0B A;  4V19 4;  5GAG W;  1EUY A;  1B75 A;  5GAD W;  2HZ7 A;  1DFU P;  5GAH W;  4IOA S;  5DM6 S;  3PIO S;  1GTS A;  1ZJW A;  1O0C A;  3W2V B;  2ZJQ S;  4IO9 S;  3CF5 S;  4U67 S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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