4NSL | Genus

Total Genus 155

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	155
sequence length	456
structure length	446
Chain Sequence	MELSSLTAVSPVDGRYGDKVSALRGIFSEYGLLKFRVQVEVRWLQKLAAHAAIKEVPAFAADANGYLDTLVANFNEEDAARIKTIERTTNHDVKAVEYFLKEKVAAIPALHDVSEFIHFACTSEDINNLSHALMLKTARDEVILPYWRQVINAVKDLATQYRDIPLLSRTHGQPATPSTLGKEMANVAYRMERQFRQLNQVEILGKINGAVGNYNAHIAAYPEVDWHQFSEEFVTSLGIQWNPYTTQIEPHDYIAELFDCIARFNTILIDFDRDVWGYIALNHFKQKTMPHKVNPIDFENSEGNLGLSNAVLHHLANKLPVSRWQRDLTDSTVLRNLGVGIGYALIAYQSTLKGVSKLEVNRDHLLDELDHNWEVLAEPIQTVMRRYGIEKPYEKLKELTRKRVDAEGMKQFIDSLALPEAEKTRLKAMTPANYIGRAVTLVDELK

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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reading 446 atoms

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Lyase
source organism	Salmonella enterica subsp. enterica serovar typhimurium
publication title	Crystallographic and kinetic studies on Adenylosuccinate Lyase from Salmonella typhimurium rcsb
molecule keywords	Adenylosuccinate lyase
total genus	155
structure length	446
sequence length	456
chains with identical sequence	B, C, D
ec nomenclature	ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date	2013-11-28

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00206	Lyase_1	Lyase
A	PF08328	ASL_C	Adenylosuccinate lyase C-terminal

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.40.30	Mainly Alpha	Orthogonal Bundle	Ribonucleotide Reductase Protein R1; domain 1	Fumarase/aspartase (C-terminal domain)	4nslA03
1.10.275.10	Mainly Alpha	Orthogonal Bundle	Fumarase C; Chain B, domain 1	Fumarase/aspartase (N-terminal domain)	4nslA01
1.20.200.10	Mainly Alpha	Up-down Bundle	Fumarase C; Chain A, domain 2	Fumarase/aspartase (Central domain)	4nslA02

4FFXA 2PTSA 1GK3A 1GKMA 1DOFA 1TJ7A 4ADLA 4BABA 1TJWA 1YFEA 4C5UA 3RD8A 4V2QA 4V2RA 1XWOA 3UNVA 1T6JA 3TV2A 2O7DA 1JSWA 1FURA 1HY1A 3OCEA 1TJVA 2QGAB 3RRPA 3QBPA 2RJSA 1KQ7A 1FUPA 4NSLA 1HY0A 4FLCA 1YISA 1TJUA 1YFMA 4NLEA 1K62A 4EFCA 1Y2MA 3E04A 1U16A 2NYNA 1DCNA 5F92A 2E9FA 2HVGA 5EYVA 2QVEA 3GTDA 3KDZA 1C3UA 2NYFA 2O78A 2O7EA 1FUQA 3R6QA 1AUWA 5F91A 4APBA 1C3CA 1FUOA 4ADMA 1T6PA 4C6GA 1I0AA 2O6YA 4CQ5A 4C5SA 3BHGA 4EEIA 2OHYA 1U15A 2PTRA 2RJRA 1VDKA 2O7FA 5HW2A 5D6BA 1B8FA 3KDYA 4APAA 1J3UA 2J91A 2VD6A 3CZOA 2X75A 1EB4A 3NZ4A 2O7BA 1Q5NA 1K7WA 3GZHA 4HGVA 2PFMA 2FUSA 1GK2A 3R6YA 4C5RA 1GKJA 1RE5A 1W27A 3R6VA 4BAAA 5EYTA 2PTQA 2YIIA 3NO9A 4MX2A 3C8TA 3OCFA
chains in the Genus database with same CATH superfamily

4FFXA 2PTSA 1GK3A 4YIHA 1GKMA 1DOFA 1TJ7A 4ADLA 4BABA 5H8WA 1TJWA 1YFEA 4C5UA 4L6AA 3RD8A 3CRVA 4V2QA 4V2RA 3U13A 1XWOA 3UNVA 5M0JA 1T6JA 2YV5A 3TV2A 2O7DA 1JSWA 1FURA 1U0LA 1HY1A 3OCEA 4L57A 1TJVA 2QGAB 3RRPA 2VL7A 3QBPA 2RJSA 1KQ7A 1FUPA 4NSLA 1Z4QA 1HY0A 4FLCA 1YISA 4YIKA 1TJUA 2D28C 1YFMA 4NLEA 1K62A 4EFCA 1Y2MA 3E04A 1U16A 2D27A 1XL7A 2NYNA 3CRW1 1DCNA 2VSFA 5F92A 2E9FA 2HVGA 5EYVA 2QVEA 3GTDA 4WNLA 4MUMA 3KDZA 1C3UA 2NYFA 2O78A 2O7EA 3F4TA 1FUQA 1T9HA 3R6QA 1AUWA 5F91A 2FELA 4APBA 1C3CA 1FUOA 4ADMA 1T6PA 1Z4KA 4C6GA 1I0AA 4IQJM 2O6YA 4C5SA 4CQ5A 3CI0K 3BHGA 4EEIA 2OHYA 1U15A 2PTRA 2RJRA 1VDKA 2O7FA 5HW2A 2JAWA 1Z4IA 2I7DA 5D6BA 1B8FA 3KDYA 4APAA 1Z4LA 1J3UA 2J91A 1XMDA 2VD6A 3CZOA 4MWOA 1Z4PX 2X75A 1EB4A 3NZ4A 1Q91A 3BWVA 2O7BA 1Q92A 4L6CA 4E88A 1IW7D 1Q5NA 1K7WA 3GZHA 4HGVA 1MH9A 2PFMA 3F4SA 2FUSA 1GK2A 3R6YA 4C5RA 1GKJA 1Z4MA 1Z4JA 2JAUA 2FENA 1RE5A 1W27A 4A15A 1XLYA 3U19A 2JAOA 5M0IA 3R6VA 4NFLA 3F4RA 4BAAA 1XL8A 5EYTA 2PTQA 2JARA 2YIIA 2RCNA 1XMCA 3NO9A 4MX2A 3C8TA 3OCFA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4FFX A;  2PTS A;  1GK3 A;  1GKM A;  1DOF A;  1TJ7 A;  4ADL A;  4BAB A;  1TJW A;  1YFE A;  4C5U A;  3RD8 A;  4V2Q A;  4V2R A;  1XWO A;  3UNV A;  1T6J A;  3TV2 A;  2O7D A;  1JSW A;  1FUR A;  1HY1 A;  3OCE A;  1TJV A;  2QGA B;  3RRP A;  3QBP A;  2RJS A;  1KQ7 A;  1FUP A;  4NSL A;  1HY0 A;  4FLC A;  1YIS A;  1TJU A;  1YFM A;  4NLE A;  1K62 A;  4EFC A;  1Y2M A;  3E04 A;  1U16 A;  2NYN A;  1DCN A;  5F92 A;  2E9F A;  2HVG A;  5EYV A;  2QVE A;  3GTD A;  3KDZ A;  1C3U A;  2NYF A;  2O78 A;  2O7E A;  1FUQ A;  3R6Q A;  1AUW A;  5F91 A;  4APB A;  1C3C A;  1FUO A;  4ADM A;  1T6P A;  4C6G A;  1I0A A;  2O6Y A;  4CQ5 A;  4C5S A;  3BHG A;  4EEI A;  2OHY A;  1U15 A;  2PTR A;  2RJR A;  1VDK A;  2O7F A;  5HW2 A;  5D6B A;  1B8F A;  3KDY A;  4APA A;  1J3U A;  2J91 A;  2VD6 A;  3CZO A;  2X75 A;  1EB4 A;  3NZ4 A;  2O7B A;  1Q5N A;  1K7W A;  3GZH A;  4HGV A;  2PFM A;  2FUS A;  1GK2 A;  3R6Y A;  4C5R A;  1GKJ A;  1RE5 A;  1W27 A;  3R6V A;  4BAA A;  5EYT A;  2PTQ A;  2YII A;  3NO9 A;  4MX2 A;  3C8T A;  3OCF A; 
#chains in the Genus database with same CATH topology
 4FFX A;  2PTS A;  1GK3 A;  4YIH A;  1GKM A;  1DOF A;  1TJ7 A;  4ADL A;  4BAB A;  5H8W A;  1TJW A;  1YFE A;  4C5U A;  4L6A A;  3RD8 A;  3CRV A;  4V2Q A;  4V2R A;  3U13 A;  1XWO A;  3UNV A;  5M0J A;  1T6J A;  2YV5 A;  3TV2 A;  2O7D A;  1JSW A;  1FUR A;  1U0L A;  1HY1 A;  3OCE A;  4L57 A;  1TJV A;  2QGA B;  3RRP A;  2VL7 A;  3QBP A;  2RJS A;  1KQ7 A;  1FUP A;  4NSL A;  1Z4Q A;  1HY0 A;  4FLC A;  1YIS A;  4YIK A;  1TJU A;  2D28 C;  1YFM A;  4NLE A;  1K62 A;  4EFC A;  1Y2M A;  3E04 A;  1U16 A;  2D27 A;  1XL7 A;  2NYN A;  3CRW 1;  1DCN A;  2VSF A;  5F92 A;  2E9F A;  2HVG A;  5EYV A;  2QVE A;  3GTD A;  4WNL A;  4MUM A;  3KDZ A;  1C3U A;  2NYF A;  2O78 A;  2O7E A;  3F4T A;  1FUQ A;  1T9H A;  3R6Q A;  1AUW A;  5F91 A;  2FEL A;  4APB A;  1C3C A;  1FUO A;  4ADM A;  1T6P A;  1Z4K A;  4C6G A;  1I0A A;  4IQJ M;  2O6Y A;  4C5S A;  4CQ5 A;  3CI0 K;  3BHG A;  4EEI A;  2OHY A;  1U15 A;  2PTR A;  2RJR A;  1VDK A;  2O7F A;  5HW2 A;  2JAW A;  1Z4I A;  2I7D A;  5D6B A;  1B8F A;  3KDY A;  4APA A;  1Z4L A;  1J3U A;  2J91 A;  1XMD A;  2VD6 A;  3CZO A;  4MWO A;  1Z4P X;  2X75 A;  1EB4 A;  3NZ4 A;  1Q91 A;  3BWV A;  2O7B A;  1Q92 A;  4L6C A;  4E88 A;  1IW7 D;  1Q5N A;  1K7W A;  3GZH A;  4HGV A;  1MH9 A;  2PFM A;  3F4S A;  2FUS A;  1GK2 A;  3R6Y A;  4C5R A;  1GKJ A;  1Z4M A;  1Z4J A;  2JAU A;  2FEN A;  1RE5 A;  1W27 A;  4A15 A;  1XLY A;  3U19 A;  2JAO A;  5M0I A;  3R6V A;  4NFL A;  3F4R A;  4BAA A;  1XL8 A;  5EYT A;  2PTQ A;  2JAR A;  2YII A;  2RCN A;  1XMC A;  3NO9 A;  4MX2 A;  3C8T A;  3OCF A; 
#chains in the Genus database with same CATH homology
 4FFX A;  2PTS A;  1GK3 A;  1GKM A;  1DOF A;  1TJ7 A;  4ADL A;  4BAB A;  1TJW A;  1YFE A;  4C5U A;  3RD8 A;  4V2Q A;  4V2R A;  1XWO A;  3UNV A;  1T6J A;  3TV2 A;  2O7D A;  1JSW A;  1FUR A;  1HY1 A;  3OCE A;  1TJV A;  2QGA B;  3RRP A;  3QBP A;  2RJS A;  1KQ7 A;  1FUP A;  4NSL A;  1HY0 A;  4FLC A;  1YIS A;  1TJU A;  1YFM A;  4NLE A;  1K62 A;  4EFC A;  1Y2M A;  3E04 A;  1U16 A;  2NYN A;  1DCN A;  5F92 A;  2E9F A;  2HVG A;  5EYV A;  2QVE A;  3GTD A;  3KDZ A;  1C3U A;  2NYF A;  2O78 A;  2O7E A;  1FUQ A;  3R6Q A;  1AUW A;  5F91 A;  4APB A;  1C3C A;  1FUO A;  4ADM A;  1T6P A;  4C6G A;  1I0A A;  2O6Y A;  4CQ5 A;  4C5S A;  3BHG A;  4EEI A;  2OHY A;  1U15 A;  2PTR A;  2RJR A;  1VDK A;  2O7F A;  5HW2 A;  5D6B A;  1B8F A;  3KDY A;  4APA A;  1J3U A;  2J91 A;  2VD6 A;  3CZO A;  2X75 A;  1EB4 A;  3NZ4 A;  2O7B A;  1Q5N A;  1K7W A;  3GZH A;  4HGV A;  2PFM A;  2FUS A;  1GK2 A;  3R6Y A;  4C5R A;  1GKJ A;  1RE5 A;  1W27 A;  3R6V A;  4BAA A;  5EYT A;  2PTQ A;  2YII A;  3NO9 A;  4MX2 A;  3C8T A;  3OCF A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4NSLA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations