4IOAS

Crystal structure of compound 4e bound to large ribosomal subunit (50s) from deinococcus radiodurans
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
175
structure length
175
Chain Sequence
MELTAKPRTPKQKLDESMIAAVAYNKENNVSFALDRKAFDRAFRQQSTTGLFDITVEGGETFPALVKAVQMDKRKRAPIHVDFYMVTYGEPVEVSVPVHTTGRSQGEVQGGLVDIVVHNLQIVAPGPRRIPQELVVDVTKMNIGDHITAGDIKLPEGCTLAADPELTVVSVLPPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates.
pubmed doi rcsb
molecule tags Ribosome/ribosome inhibitor
molecule keywords 23S ribosomal RNA
total genus 25
structure length 175
sequence length 175
ec nomenclature
pdb deposition date 2013-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 4ioaS01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 4ioaS02
1GTRA 4IOAS 1GTSA 5BNZA 4JXZA 4JYZA 1O0CA 3PIOS 4JXXA 2RD2A 4WFBS 4H3SA 4U67S 2ZJPS 1QTQA 4WFAS 5IZNA 1EUYA 1B75A 3PIPS 5JVGS 2ZJRS 1QRUA 1QRTA 1QRSA 5DM7S 3DLLS 3J7ZV 5HL7S 5GADW 4WF9S 1EUQA 1D6KA 5GAEW 2RE8A 5GAHW 1EXDA 4WFNS 1DFUP 1FEUA 5JVHS 4IOCS 2HZ7A 1NYLA 5GAGW 4WCES 5DM6S 1O0BA 4UY88 2ZJQS 4IO9S 3AIIA 3CF5S 1ZJWA 4P2BA
chains in the Genus database with same CATH superfamily
2A6HA 3HKZD 4Q4ZA 3GTMC 4C3HC 4YFNA 1QTQA 4XLPA 2BE5A 1SFOC 2L3UA 3HOVC 4BBSC 1B75A 4C3IC 4OIRA 2E2JC 4G7OA 2CX8A 1TWFC 3W2WB 3DXJA 5DM7S 3DLLS 3HOXC 2PICA 4GZYA 1HQMA 1EUQA 1D6KA 3PO2C 3S16C 4XSXA 1IW7A 5JVHS 4Y52C 2VUMC 4IOCS 2Y0SD 1SMYA 3I4NC 5HQHA 1Z85A 1NYLA 4WCES 3S2HC 4OIOA 4A3EC 3HOUC 2EGWA 1VHKA 3W2VB 4C2MC 2JA5C 3H0GC 4L69A 4BY1C 3EQLA 4A3BC 3I4MC 2Z0YA 1GTRA 1GTSA 2WAQD 5BNZA 4LLGA 4MEYA 5IYBC 4JXZA 4YFKA 2PPBA 3GTPC 3S1MC 3K7AC 1ZYRA 1BDFA 5C4XC 2KXYA 1VHYA 3S1RC 3S14C 2ZJPS 2A68A 1EUYA 5IZNA 2A6EA 2JA6C 1TWAC 3WODA 2R7ZC 1Y1VC 5IP7C 4Y7NC 4X6AC 2EGVA 2AE0X 2ZJRS 5JVGS 1TWHC 1QRUA 1QRSA 1NXZA 4A3MC 2PJJA 4JK1A 4A3FC 5IP9C 1Y1WC 2RE8A 4OINA 4BXXC 4WFNS 2L5NA 1DFUP 4OIPA 4A3JC 4MEXA 3GTJC 5D4DA 4A3KC 4A3LC 4E8BA 3X1LB 4G7HA 4XSZA 3S15C 2E2HC 1R9TC 3H3VD 5FLMC 4AYBD 3GTOC 4ZH4A 5C3EC 3HOYC 2B63C 2JA8C 3HOZC 3S1QC 3CZBA 4QIWD 4Q5SA 4V194 4JYZA 3GTKC 1O0CA 3PIOS 3GTLC 2PNWA 4WFBS 4C3JC 4U67S 3GTQC 4WFAS 1K83C 1UDXA 2G5DA 5IYDC 4MQ9A 2KQ1A 1QRTA 4KN7A 2JA7C 2A69A 4NOIA 4WF9S 4XLNA 4A3IC 5C44C 2O5JA 1EXDA 5GAHW 1I3QC 5TMCA 3HOWC 2HZ7A 1YNJA 4YFXA 3M3YC 3RZOC 5C4JC 2G6GA 1YNNA 5DM6S 4A3GC 4UY88 4YG2A 2NVYC 4IO9S 3RZDC 3CF5S 2WB1D 1I6VA 3S2DC 5TMFA 4KMUA 4P2BA 2PMZD 2GAEA 4IOAS 4BY7C 1TWCC 2E2IC 3CQZC 2NVXC 5IYCC 4JXXA 4LJZA 2RD2A 3PO3C 4H3SA 4J3CA 3PIPS 4OIQA 1WCMC 3FKIC 4A3CC 4H4KA 3S1NC 3J7ZV 5HL7S 3M4OC 5GADW 2PA8D 5GAEW 4A3DC 1I6HC 3KW2A 1FEUA 4LK1A 4BBRC 2NWAA 2NVTC 2CW0A 1V6ZA 4A93C 1I50C 2NVQC 4G7ZA 1TWGC 5GAGW 2YU9C 4LK0A 2O5IA 2R92C 2R93C 2KPUA 3S17C 1O0BA 2ZJQS 4KN4A 3AIIA 3GTGC 1ZJWA 3LYWA 4QJVA 2PI8A
chains in the Genus database with same CATH topology
1GTRA 4IOAS 1GTSA 5BNZA 4JXZA 4V194 4JYZA 1O0CA 3PIOS 4JXXA 2RD2A 4WFBS 4H3SA 4U67S 2ZJPS 1QTQA 4WFAS 5IZNA 1EUYA 1B75A 3PIPS 1UDXA 3W2WB 5JVGS 2ZJRS 4H4KA 1QRUA 1QRTA 1QRSA 5DM7S 3DLLS 3J7ZV 5HL7S 5GADW 4WF9S 1EUQA 1D6KA 5GAEW 2RE8A 5GAHW 1EXDA 4WFNS 1DFUP 1FEUA 5JVHS 4IOCS 2HZ7A 3X1LB 1NYLA 5GAGW 4WCES 5DM6S 1O0BA 4UY88 2ZJQS 3W2VB 4IO9S 3AIIA 3CF5S 1ZJWA 4P2BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GTR A;  4IOA S;  1GTS A;  5BNZ A;  4JXZ A;  4JYZ A;  1O0C A;  3PIO S;  4JXX A;  2RD2 A;  4WFB S;  4H3S A;  4U67 S;  2ZJP S;  1QTQ A;  4WFA S;  5IZN A;  1EUY A;  1B75 A;  3PIP S;  5JVG S;  2ZJR S;  1QRU A;  1QRT A;  1QRS A;  5DM7 S;  3DLL S;  3J7Z V;  5HL7 S;  5GAD W;  4WF9 S;  1EUQ A;  1D6K A;  5GAE W;  2RE8 A;  5GAH W;  1EXD A;  4WFN S;  1DFU P;  1FEU A;  5JVH S;  4IOC S;  2HZ7 A;  1NYL A;  5GAG W;  4WCE S;  5DM6 S;  1O0B A;  4UY8 8;  2ZJQ S;  4IO9 S;  3AII A;  3CF5 S;  1ZJW A;  4P2B A; 
#chains in the Genus database with same CATH topology
 2A6H A;  3HKZ D;  4Q4Z A;  3GTM C;  4C3H C;  4YFN A;  1QTQ A;  4XLP A;  2BE5 A;  1SFO C;  2L3U A;  3HOV C;  4BBS C;  1B75 A;  4C3I C;  4OIR A;  2E2J C;  4G7O A;  2CX8 A;  1TWF C;  3W2W B;  3DXJ A;  5DM7 S;  3DLL S;  3HOX C;  2PIC A;  4GZY A;  1HQM A;  1EUQ A;  1D6K A;  3PO2 C;  3S16 C;  4XSX A;  1IW7 A;  5JVH S;  4Y52 C;  2VUM C;  4IOC S;  2Y0S D;  1SMY A;  3I4N C;  5HQH A;  1Z85 A;  1NYL A;  4WCE S;  3S2H C;  4OIO A;  4A3E C;  3HOU C;  2EGW A;  1VHK A;  3W2V B;  4C2M C;  2JA5 C;  3H0G C;  4L69 A;  4BY1 C;  3EQL A;  4A3B C;  3I4M C;  2Z0Y A;  1GTR A;  1GTS A;  2WAQ D;  5BNZ A;  4LLG A;  4MEY A;  5IYB C;  4JXZ A;  4YFK A;  2PPB A;  3GTP C;  3S1M C;  3K7A C;  1ZYR A;  1BDF A;  5C4X C;  2KXY A;  1VHY A;  3S1R C;  3S14 C;  2ZJP S;  2A68 A;  1EUY A;  5IZN A;  2A6E A;  2JA6 C;  1TWA C;  3WOD A;  2R7Z C;  1Y1V C;  5IP7 C;  4Y7N C;  4X6A C;  2EGV A;  2AE0 X;  2ZJR S;  5JVG S;  1TWH C;  1QRU A;  1QRS A;  1NXZ A;  4A3M C;  2PJJ A;  4JK1 A;  4A3F C;  5IP9 C;  1Y1W C;  2RE8 A;  4OIN A;  4BXX C;  4WFN S;  2L5N A;  1DFU P;  4OIP A;  4A3J C;  4MEX A;  3GTJ C;  5D4D A;  4A3K C;  4A3L C;  4E8B A;  3X1L B;  4G7H A;  4XSZ A;  3S15 C;  2E2H C;  1R9T C;  3H3V D;  5FLM C;  4AYB D;  3GTO C;  4ZH4 A;  5C3E C;  3HOY C;  2B63 C;  2JA8 C;  3HOZ C;  3S1Q C;  3CZB A;  4QIW D;  4Q5S A;  4V19 4;  4JYZ A;  3GTK C;  1O0C A;  3PIO S;  3GTL C;  2PNW A;  4WFB S;  4C3J C;  4U67 S;  3GTQ C;  4WFA S;  1K83 C;  1UDX A;  2G5D A;  5IYD C;  4MQ9 A;  2KQ1 A;  1QRT A;  4KN7 A;  2JA7 C;  2A69 A;  4NOI A;  4WF9 S;  4XLN A;  4A3I C;  5C44 C;  2O5J A;  1EXD A;  5GAH W;  1I3Q C;  5TMC A;  3HOW C;  2HZ7 A;  1YNJ A;  4YFX A;  3M3Y C;  3RZO C;  5C4J C;  2G6G A;  1YNN A;  5DM6 S;  4A3G C;  4UY8 8;  4YG2 A;  2NVY C;  4IO9 S;  3RZD C;  3CF5 S;  2WB1 D;  1I6V A;  3S2D C;  5TMF A;  4KMU A;  4P2B A;  2PMZ D;  2GAE A;  4IOA S;  4BY7 C;  1TWC C;  2E2I C;  3CQZ C;  2NVX C;  5IYC C;  4JXX A;  4LJZ A;  2RD2 A;  3PO3 C;  4H3S A;  4J3C A;  3PIP S;  4OIQ A;  1WCM C;  3FKI C;  4A3C C;  4H4K A;  3S1N C;  3J7Z V;  5HL7 S;  3M4O C;  5GAD W;  2PA8 D;  5GAE W;  4A3D C;  1I6H C;  3KW2 A;  1FEU A;  4LK1 A;  4BBR C;  2NWA A;  2NVT C;  2CW0 A;  1V6Z A;  4A93 C;  1I50 C;  2NVQ C;  4G7Z A;  1TWG C;  5GAG W;  2YU9 C;  4LK0 A;  2O5I A;  2R92 C;  2R93 C;  2KPU A;  3S17 C;  1O0B A;  2ZJQ S;  4KN4 A;  3AII A;  3GTG C;  1ZJW A;  3LYW A;  4QJV A;  2PI8 A; 
#chains in the Genus database with same CATH homology
 1GTR A;  4IOA S;  1GTS A;  5BNZ A;  4JXZ A;  4V19 4;  4JYZ A;  1O0C A;  3PIO S;  4JXX A;  2RD2 A;  4WFB S;  4H3S A;  4U67 S;  2ZJP S;  1QTQ A;  4WFA S;  5IZN A;  1EUY A;  1B75 A;  3PIP S;  1UDX A;  3W2W B;  5JVG S;  2ZJR S;  4H4K A;  1QRU A;  1QRT A;  1QRS A;  5DM7 S;  3DLL S;  3J7Z V;  5HL7 S;  5GAD W;  4WF9 S;  1EUQ A;  1D6K A;  5GAE W;  2RE8 A;  5GAH W;  1EXD A;  4WFN S;  1DFU P;  1FEU A;  5JVH S;  4IOC S;  2HZ7 A;  3X1L B;  1NYL A;  5GAG W;  4WCE S;  5DM6 S;  1O0B A;  4UY8 8;  2ZJQ S;  3W2V B;  4IO9 S;  3AII A;  3CF5 S;  1ZJW A;  4P2B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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