4IOCS

Crystal structure of compound 4f bound to large ribosomal subunit (50s) from deinococcus radiodurans
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
175
structure length
175
Chain Sequence
MELTAKPRTPKQKLDESMIAAVAYNKENNVSFALDRKAFDRAFRQQSTTGLFDITVEGGETFPALVKAVQMDKRKRAPIHVDFYMVTYGEPVEVSVPVHTTGRSQGEVQGGLVDIVVHNLQIVAPGPRRIPQELVVDVTKMNIGDHITAGDIKLPEGCTLAADPELTVVSVLPPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates.
pubmed doi rcsb
molecule tags Ribosome/ribosome inhibitor
molecule keywords 23S ribosomal RNA
total genus 21
structure length 175
sequence length 175
ec nomenclature
pdb deposition date 2013-01-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 4iocS01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 4iocS02
5JVHS 3AIIA 3PIOS 4JXXA 5JVGS 4H3SA 1GTSA 1QRTA 1NYLA 5DM6S 4WFNS 1FEUA 2ZJQS 5GAEW 5IZNA 3J7ZV 4WFBS 1DFUP 5GAGW 3PIPS 2ZJRS 5BNZA 1QRUA 3DLLS 4WF9S 4JXZA 1GTRA 2ZJPS 1O0CA 4JYZA 5HL7S 1QTQA 4U67S 4UY88 5DM7S 4IOCS 1O0BA 1D6KA 1EUYA 1QRSA 4WFAS 4WCES 1EXDA 1EUQA 4P2BA 2HZ7A 5GADW 2RE8A 5GAHW 1ZJWA 3CF5S 1B75A 2RD2A 4IO9S 4IOAS
chains in the Genus database with same CATH superfamily
2JA5C 4OIQA 3S2HC 3AIIA 3EQLA 5IYDC 4JXXA 1QRTA 4G7HA 1HQMA 3WODA 4OINA 3HOXC 4QIWD 4BY1C 3S14C 1TWCC 2WAQD 3PO3C 5GAEW 2NWAA 2ZJRS 3RZDC 4Q5SA 2BE5A 3FKIC 4A3MC 3W2WB 3GTGC 5TMFA 4E8BA 1VHYA 1SFOC 2PMZD 2JA8C 4C3HC 4A3JC 2R93C 3S17C 5HL7S 4XLNA 4BBRC 2EGVA 4A3CC 3CQZC 5C44C 5DM7S 4IOCS 4A3BC 4A3IC 3I4NC 1Y1WC 3K7AC 1EUQA 4C3JC 4P2BA 4C2MC 1YNJA 5C4JC 2PPBA 3H0GC 1Y1VC 2L5NA 3W2VB 3HOVC 4J3CA 2WB1D 3S1QC 4LK0A 3CZBA 3I4MC 1I50C 1NYLA 5DM6S 5FLMC 1ZYRA 3DXJA 2GAEA 1SMYA 1UDXA 5GAGW 4L69A 3PIPS 5IP7C 5IYBC 4JK1A 1QRUA 4ZH4A 4A3LC 4WF9S 4A3FC 3S1NC 2NVYC 2A6EA 2NVXC 3S15C 3GTLC 2ZJPS 1O0CA 4JYZA 2KQ1A 4U67S 2Z0YA 4G7ZA 4MQ9A 4UY88 2JA6C 3HOUC 3M4OC 1O0BA 1VHKA 1D6KA 2A69A 3GTOC 5C3EC 3S16C 4OIRA 4GZYA 4LJZA 4WFAS 2E2IC 1TWFC 2NVQC 4G7OA 2HZ7A 5GADW 1TWHC 1V6ZA 2RE8A 2R92C 3M3YC 4C3IC 4X6AC 4QJVA 4XLPA 2R7ZC 4A3EC 2E2HC 5JVHS 3PIOS 4V194 3GTPC 1GTSA 4OIPA 2PI8A 4H3SA 4A3KC 2PICA 2G5DA 1WCMC 4MEYA 4BBSC 5IZNA 4YFKA 3HOWC 3S1MC 2CW0A 2B63C 4YFNA 2O5JA 3X1LB 1IW7A 1I6VA 5HQHA 1YNNA 2A6HA 3H3VD 2Y0SD 2YU9C 2KPUA 5C4XC 2A68A 1QTQA 4NOIA 4Q4ZA 2NVTC 5IP9C 5D4DA 1EUYA 5IYCC 1TWGC 2L3UA 3S1RC 2PJJA 1QRSA 4MEXA 1EXDA 3GTKC 1K83C 1BDFA 2AE0X 4XSZA 2E2JC 5GAHW 4H4KA 1ZJWA 3CF5S 4BY7C 2RD2A 4IOAS 3KW2A 3GTJC 3PO2C 1Z85A 2G6GA 4WFNS 1FEUA 4BXXC 2ZJQS 3LYWA 4KMUA 4YG2A 1DFUP 3J7ZV 4WFBS 2JA7C 4A93C 3HOYC 4A3GC 3S2DC 2PNWA 5BNZA 4Y7NC 3HOZC 1I6HC 4KN7A 3DLLS 4AYBD 4JXZA 1GTRA 3HKZD 3GTQC 1NXZA 4A3DC 1I3QC 4OIOA 1R9TC 2O5IA 3RZOC 4LK1A 3GTMC 4YFXA 2EGWA 2PA8D 4KN4A 4XSXA 2KXYA 5TMCA 4WCES 2CX8A 4LLGA 1TWAC 2VUMC 5JVGS 1B75A 4Y52C 4IO9S
chains in the Genus database with same CATH topology
5JVHS 3AIIA 3PIOS 4V194 4JXXA 5JVGS 4H3SA 1GTSA 1QRTA 1NYLA 5DM6S 4WFNS 1FEUA 2ZJQS 5GAEW 5IZNA 3J7ZV 4WFBS 1DFUP 1UDXA 5GAGW 3PIPS 2ZJRS 5BNZA 3X1LB 3W2WB 1QRUA 3DLLS 4WF9S 4JXZA 1GTRA 2ZJPS 1O0CA 4JYZA 5HL7S 1QTQA 4U67S 4UY88 5DM7S 4IOCS 1O0BA 1D6KA 1EUYA 1QRSA 4WFAS 4WCES 1EXDA 1EUQA 4P2BA 2HZ7A 5GADW 2RE8A 5GAHW 4H4KA 1ZJWA 3CF5S 1B75A 2RD2A 3W2VB 4IO9S 4IOAS
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5JVH S;  3AII A;  3PIO S;  4JXX A;  5JVG S;  4H3S A;  1GTS A;  1QRT A;  1NYL A;  5DM6 S;  4WFN S;  1FEU A;  2ZJQ S;  5GAE W;  5IZN A;  3J7Z V;  4WFB S;  1DFU P;  5GAG W;  3PIP S;  2ZJR S;  5BNZ A;  1QRU A;  3DLL S;  4WF9 S;  4JXZ A;  1GTR A;  2ZJP S;  1O0C A;  4JYZ A;  5HL7 S;  1QTQ A;  4U67 S;  4UY8 8;  5DM7 S;  4IOC S;  1O0B A;  1D6K A;  1EUY A;  1QRS A;  4WFA S;  4WCE S;  1EXD A;  1EUQ A;  4P2B A;  2HZ7 A;  5GAD W;  2RE8 A;  5GAH W;  1ZJW A;  3CF5 S;  1B75 A;  2RD2 A;  4IO9 S;  4IOA S; 
#chains in the Genus database with same CATH topology
 2JA5 C;  4OIQ A;  3S2H C;  3AII A;  3EQL A;  5IYD C;  4JXX A;  1QRT A;  4G7H A;  1HQM A;  3WOD A;  4OIN A;  3HOX C;  4QIW D;  4BY1 C;  3S14 C;  1TWC C;  2WAQ D;  3PO3 C;  5GAE W;  2NWA A;  2ZJR S;  3RZD C;  4Q5S A;  2BE5 A;  3FKI C;  4A3M C;  3W2W B;  3GTG C;  5TMF A;  4E8B A;  1VHY A;  1SFO C;  2PMZ D;  2JA8 C;  4C3H C;  4A3J C;  2R93 C;  3S17 C;  5HL7 S;  4XLN A;  4BBR C;  2EGV A;  4A3C C;  3CQZ C;  5C44 C;  5DM7 S;  4IOC S;  4A3B C;  4A3I C;  3I4N C;  1Y1W C;  3K7A C;  1EUQ A;  4C3J C;  4P2B A;  4C2M C;  1YNJ A;  5C4J C;  2PPB A;  3H0G C;  1Y1V C;  2L5N A;  3W2V B;  3HOV C;  4J3C A;  2WB1 D;  3S1Q C;  4LK0 A;  3CZB A;  3I4M C;  1I50 C;  1NYL A;  5DM6 S;  5FLM C;  1ZYR A;  3DXJ A;  2GAE A;  1SMY A;  1UDX A;  5GAG W;  4L69 A;  3PIP S;  5IP7 C;  5IYB C;  4JK1 A;  1QRU A;  4ZH4 A;  4A3L C;  4WF9 S;  4A3F C;  3S1N C;  2NVY C;  2A6E A;  2NVX C;  3S15 C;  3GTL C;  2ZJP S;  1O0C A;  4JYZ A;  2KQ1 A;  4U67 S;  2Z0Y A;  4G7Z A;  4MQ9 A;  4UY8 8;  2JA6 C;  3HOU C;  3M4O C;  1O0B A;  1VHK A;  1D6K A;  2A69 A;  3GTO C;  5C3E C;  3S16 C;  4OIR A;  4GZY A;  4LJZ A;  4WFA S;  2E2I C;  1TWF C;  2NVQ C;  4G7O A;  2HZ7 A;  5GAD W;  1TWH C;  1V6Z A;  2RE8 A;  2R92 C;  3M3Y C;  4C3I C;  4X6A C;  4QJV A;  4XLP A;  2R7Z C;  4A3E C;  2E2H C;  5JVH S;  3PIO S;  4V19 4;  3GTP C;  1GTS A;  4OIP A;  2PI8 A;  4H3S A;  4A3K C;  2PIC A;  2G5D A;  1WCM C;  4MEY A;  4BBS C;  5IZN A;  4YFK A;  3HOW C;  3S1M C;  2CW0 A;  2B63 C;  4YFN A;  2O5J A;  3X1L B;  1IW7 A;  1I6V A;  5HQH A;  1YNN A;  2A6H A;  3H3V D;  2Y0S D;  2YU9 C;  2KPU A;  5C4X C;  2A68 A;  1QTQ A;  4NOI A;  4Q4Z A;  2NVT C;  5IP9 C;  5D4D A;  1EUY A;  5IYC C;  1TWG C;  2L3U A;  3S1R C;  2PJJ A;  1QRS A;  4MEX A;  1EXD A;  3GTK C;  1K83 C;  1BDF A;  2AE0 X;  4XSZ A;  2E2J C;  5GAH W;  4H4K A;  1ZJW A;  3CF5 S;  4BY7 C;  2RD2 A;  4IOA S;  3KW2 A;  3GTJ C;  3PO2 C;  1Z85 A;  2G6G A;  4WFN S;  1FEU A;  4BXX C;  2ZJQ S;  3LYW A;  4KMU A;  4YG2 A;  1DFU P;  3J7Z V;  4WFB S;  2JA7 C;  4A93 C;  3HOY C;  4A3G C;  3S2D C;  2PNW A;  5BNZ A;  4Y7N C;  3HOZ C;  1I6H C;  4KN7 A;  3DLL S;  4AYB D;  4JXZ A;  1GTR A;  3HKZ D;  3GTQ C;  1NXZ A;  4A3D C;  1I3Q C;  4OIO A;  1R9T C;  2O5I A;  3RZO C;  4LK1 A;  3GTM C;  4YFX A;  2EGW A;  2PA8 D;  4KN4 A;  4XSX A;  2KXY A;  5TMC A;  4WCE S;  2CX8 A;  4LLG A;  1TWA C;  2VUM C;  5JVG S;  1B75 A;  4Y52 C;  4IO9 S; 
#chains in the Genus database with same CATH homology
 5JVH S;  3AII A;  3PIO S;  4V19 4;  4JXX A;  5JVG S;  4H3S A;  1GTS A;  1QRT A;  1NYL A;  5DM6 S;  4WFN S;  1FEU A;  2ZJQ S;  5GAE W;  5IZN A;  3J7Z V;  4WFB S;  1DFU P;  1UDX A;  5GAG W;  3PIP S;  2ZJR S;  5BNZ A;  3X1L B;  3W2W B;  1QRU A;  3DLL S;  4WF9 S;  4JXZ A;  1GTR A;  2ZJP S;  1O0C A;  4JYZ A;  5HL7 S;  1QTQ A;  4U67 S;  4UY8 8;  5DM7 S;  4IOC S;  1O0B A;  1D6K A;  1EUY A;  1QRS A;  4WFA S;  4WCE S;  1EXD A;  1EUQ A;  4P2B A;  2HZ7 A;  5GAD W;  2RE8 A;  5GAH W;  4H4K A;  1ZJW A;  3CF5 S;  1B75 A;  2RD2 A;  3W2V B;  4IO9 S;  4IOA S; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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