5HL7S

The crystal structure of the large ribosomal subunit of staphylococcus aureus in complex with lefamulin
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
167
structure length
167
Chain Sequence
SLKSIIRQGKQTRSDLKQLRKSGKVPAVVYGYGTKNVSVKVDEVEFIKVIREVGRNGVIELGVGSKTIKVMVADYQFDPLKNQITHIDFLAINMSEERTVEVPVQLVGEAVGAKEGGVVEQPLFNLEVTATPDNIPEAIEVDITELNINDSLTVADVKVTGDFKIEN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 50S ribosomal protein L2
total genus 22
structure length 167
sequence length 167
ec nomenclature
pdb deposition date 2016-01-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 5hl7S01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 5hl7S02
4WFBS 4P2BA 3DLLS 1B75A 5GAEW 4WCES 5GAGW 1GTRA 1EUYA 1O0BA 1QRUA 3AIIA 4IO9S 1QTQA 4WFNS 4WFAS 2HZ7A 1ZJWA 1EXDA 1QRTA 5DM6S 1D6KA 5JVGS 3J7ZV 5HL7S 5BNZA 4U67S 2RD2A 1EUQA 4UY88 5JVHS 1GTSA 4IOAS 2ZJQS 2ZJRS 5GAHW 1NYLA 3CF5S 4IOCS 5IZNA 3PIOS 4JXXA 1QRSA 4JXZA 1DFUP 2RE8A 5DM7S 4H3SA 3PIPS 2ZJPS 5GADW 1O0CA 4WF9S 1FEUA 4JYZA
chains in the Genus database with same CATH superfamily
3S1NC 4P2BA 3HOUC 4YG2A 4C3IC 3W2WB 5GAEW 3GTGC 3S15C 1O0BA 1QTQA 1R9TC 2PPBA 4Y52C 2HZ7A 4E8BA 2PJJA 4LK1A 2NVQC 3S1MC 4OIQA 1EXDA 4A3DC 4A3KC 3M4OC 3I4NC 3X1LB 1D6KA 4QJVA 3J7ZV 2PNWA 3RZDC 2Y0SD 4UY88 3I4MC 1GTSA 4YFNA 2ZJQS 5HQHA 2PMZD 3HOVC 4LLGA 2NVYC 2Z0YA 4YFKA 3CF5S 4IOCS 5IYDC 1Y1WC 4XLNA 3S16C 3FKIC 4JXZA 1DFUP 3PO3C 2RE8A 4A3EC 3PO2C 1TWAC 4LJZA 4H3SA 5GADW 3HOZC 3KW2A 4MEYA 1B75A 4OIOA 3M3YC 2JA8C 3S17C 4OIPA 3DLLS 2VUMC 2PI8A 4A3MC 4Q4ZA 4L69A 2BE5A 3GTMC 4G7OA 2JA7C 3AIIA 1VHKA 2O5JA 1I6HC 1IW7A 3DXJA 5IP7C 2YU9C 2JA6C 4KN7A 1ZJWA 4JK1A 5C44C 1K83C 4Q5SA 5BNZA 2O5IA 5JVHS 1YNNA 2KQ1A 2NVTC 4ZH4A 5IZNA 5FLMC 2B63C 2L3UA 1QRSA 1TWHC 1I6VA 3HOXC 4A3JC 2EGVA 2G6GA 3HOYC 2R92C 1BDFA 1I50C 3GTQC 3S2DC 1I3QC 3H3VD 1VHYA 4WCES 1GTRA 1QRUA 4WFNS 4QIWD 2CX8A 2KPUA 4Y7NC 1WCMC 5C4JC 2NVXC 4KN4A 4NOIA 2CW0A 2NWAA 1YNJA 2PICA 2JA5C 4BBRC 3K7AC 5DM6S 1HQMA 2A68A 4XSXA 1UDXA 3GTJC 2E2IC 5HL7S 4U67S 2RD2A 1EUQA 1Y1VC 2G5DA 2GAEA 2ZJRS 2A6EA 2R7ZC 1NYLA 4BXXC 2WAQD 4H4KA 3PIOS 3GTOC 4BY7C 3CQZC 2R93C 2EGWA 2A6HA 2A69A 4C2MC 4A3FC 4XLPA 1TWGC 5DM7S 4LK0A 2ZJPS 3PIPS 4YFXA 3H0GC 4GZYA 4V194 4A93C 2PA8D 3S1QC 3RZOC 2E2HC 4OIRA 4JYZA 4A3BC 2L5NA 3GTPC 4WFBS 4XSZA 4C3JC 4A3LC 3GTLC 3HOWC 1NXZA 5GAGW 1Z85A 1EUYA 4MQ9A 5C4XC 3S2HC 4IO9S 5D4DA 3CZBA 4WFAS 5IYBC 5IYCC 4X6AC 2KXYA 1V6ZA 4A3IC 3S1RC 3W2VB 2WB1D 5TMCA 4BBSC 4J3CA 4OINA 1ZYRA 1QRTA 5IP9C 2AE0X 5JVGS 3WODA 4AYBD 4G7ZA 1SFOC 4IOAS 4G7HA 5GAHW 2E2JC 1TWFC 4BY1C 4A3CC 3GTKC 3S14C 4JXXA 4C3HC 4A3GC 1TWCC 3EQLA 1SMYA 3HKZD 3LYWA 5TMFA 1O0CA 4KMUA 4WF9S 4MEXA 1FEUA 5C3EC
chains in the Genus database with same CATH topology
4WFBS 4P2BA 3DLLS 1B75A 3W2WB 5GAEW 4WCES 5GAGW 1GTRA 1EUYA 1O0BA 1QRUA 3AIIA 4IO9S 1QTQA 4WFNS 4WFAS 2HZ7A 3W2VB 1ZJWA 1EXDA 1QRTA 5DM6S 3X1LB 1D6KA 5JVGS 1UDXA 3J7ZV 5HL7S 5BNZA 4U67S 2RD2A 1EUQA 4UY88 5JVHS 1GTSA 4IOAS 2ZJQS 2ZJRS 5GAHW 1NYLA 3CF5S 4IOCS 5IZNA 4H4KA 3PIOS 4JXXA 1QRSA 4JXZA 1DFUP 2RE8A 5DM7S 4H3SA 3PIPS 2ZJPS 5GADW 1O0CA 4V194 4WF9S 1FEUA 4JYZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4WFB S;  4P2B A;  3DLL S;  1B75 A;  5GAE W;  4WCE S;  5GAG W;  1GTR A;  1EUY A;  1O0B A;  1QRU A;  3AII A;  4IO9 S;  1QTQ A;  4WFN S;  4WFA S;  2HZ7 A;  1ZJW A;  1EXD A;  1QRT A;  5DM6 S;  1D6K A;  5JVG S;  3J7Z V;  5HL7 S;  5BNZ A;  4U67 S;  2RD2 A;  1EUQ A;  4UY8 8;  5JVH S;  1GTS A;  4IOA S;  2ZJQ S;  2ZJR S;  5GAH W;  1NYL A;  3CF5 S;  4IOC S;  5IZN A;  3PIO S;  4JXX A;  1QRS A;  4JXZ A;  1DFU P;  2RE8 A;  5DM7 S;  4H3S A;  3PIP S;  2ZJP S;  5GAD W;  1O0C A;  4WF9 S;  1FEU A;  4JYZ A; 
#chains in the Genus database with same CATH topology
 3S1N C;  4P2B A;  3HOU C;  4YG2 A;  4C3I C;  3W2W B;  5GAE W;  3GTG C;  3S15 C;  1O0B A;  1QTQ A;  1R9T C;  2PPB A;  4Y52 C;  2HZ7 A;  4E8B A;  2PJJ A;  4LK1 A;  2NVQ C;  3S1M C;  4OIQ A;  1EXD A;  4A3D C;  4A3K C;  3M4O C;  3I4N C;  3X1L B;  1D6K A;  4QJV A;  3J7Z V;  2PNW A;  3RZD C;  2Y0S D;  4UY8 8;  3I4M C;  1GTS A;  4YFN A;  2ZJQ S;  5HQH A;  2PMZ D;  3HOV C;  4LLG A;  2NVY C;  2Z0Y A;  4YFK A;  3CF5 S;  4IOC S;  5IYD C;  1Y1W C;  4XLN A;  3S16 C;  3FKI C;  4JXZ A;  1DFU P;  3PO3 C;  2RE8 A;  4A3E C;  3PO2 C;  1TWA C;  4LJZ A;  4H3S A;  5GAD W;  3HOZ C;  3KW2 A;  4MEY A;  1B75 A;  4OIO A;  3M3Y C;  2JA8 C;  3S17 C;  4OIP A;  3DLL S;  2VUM C;  2PI8 A;  4A3M C;  4Q4Z A;  4L69 A;  2BE5 A;  3GTM C;  4G7O A;  2JA7 C;  3AII A;  1VHK A;  2O5J A;  1I6H C;  1IW7 A;  3DXJ A;  5IP7 C;  2YU9 C;  2JA6 C;  4KN7 A;  1ZJW A;  4JK1 A;  5C44 C;  1K83 C;  4Q5S A;  5BNZ A;  2O5I A;  5JVH S;  1YNN A;  2KQ1 A;  2NVT C;  4ZH4 A;  5IZN A;  5FLM C;  2B63 C;  2L3U A;  1QRS A;  1TWH C;  1I6V A;  3HOX C;  4A3J C;  2EGV A;  2G6G A;  3HOY C;  2R92 C;  1BDF A;  1I50 C;  3GTQ C;  3S2D C;  1I3Q C;  3H3V D;  1VHY A;  4WCE S;  1GTR A;  1QRU A;  4WFN S;  4QIW D;  2CX8 A;  2KPU A;  4Y7N C;  1WCM C;  5C4J C;  2NVX C;  4KN4 A;  4NOI A;  2CW0 A;  2NWA A;  1YNJ A;  2PIC A;  2JA5 C;  4BBR C;  3K7A C;  5DM6 S;  1HQM A;  2A68 A;  4XSX A;  1UDX A;  3GTJ C;  2E2I C;  5HL7 S;  4U67 S;  2RD2 A;  1EUQ A;  1Y1V C;  2G5D A;  2GAE A;  2ZJR S;  2A6E A;  2R7Z C;  1NYL A;  4BXX C;  2WAQ D;  4H4K A;  3PIO S;  3GTO C;  4BY7 C;  3CQZ C;  2R93 C;  2EGW A;  2A6H A;  2A69 A;  4C2M C;  4A3F C;  4XLP A;  1TWG C;  5DM7 S;  4LK0 A;  2ZJP S;  3PIP S;  4YFX A;  3H0G C;  4GZY A;  4V19 4;  4A93 C;  2PA8 D;  3S1Q C;  3RZO C;  2E2H C;  4OIR A;  4JYZ A;  4A3B C;  2L5N A;  3GTP C;  4WFB S;  4XSZ A;  4C3J C;  4A3L C;  3GTL C;  3HOW C;  1NXZ A;  5GAG W;  1Z85 A;  1EUY A;  4MQ9 A;  5C4X C;  3S2H C;  4IO9 S;  5D4D A;  3CZB A;  4WFA S;  5IYB C;  5IYC C;  4X6A C;  2KXY A;  1V6Z A;  4A3I C;  3S1R C;  3W2V B;  2WB1 D;  5TMC A;  4BBS C;  4J3C A;  4OIN A;  1ZYR A;  1QRT A;  5IP9 C;  2AE0 X;  5JVG S;  3WOD A;  4AYB D;  4G7Z A;  1SFO C;  4IOA S;  4G7H A;  5GAH W;  2E2J C;  1TWF C;  4BY1 C;  4A3C C;  3GTK C;  3S14 C;  4JXX A;  4C3H C;  4A3G C;  1TWC C;  3EQL A;  1SMY A;  3HKZ D;  3LYW A;  5TMF A;  1O0C A;  4KMU A;  4WF9 S;  4MEX A;  1FEU A;  5C3E C; 
#chains in the Genus database with same CATH homology
 4WFB S;  4P2B A;  3DLL S;  1B75 A;  3W2W B;  5GAE W;  4WCE S;  5GAG W;  1GTR A;  1EUY A;  1O0B A;  1QRU A;  3AII A;  4IO9 S;  1QTQ A;  4WFN S;  4WFA S;  2HZ7 A;  3W2V B;  1ZJW A;  1EXD A;  1QRT A;  5DM6 S;  3X1L B;  1D6K A;  5JVG S;  1UDX A;  3J7Z V;  5HL7 S;  5BNZ A;  4U67 S;  2RD2 A;  1EUQ A;  4UY8 8;  5JVH S;  1GTS A;  4IOA S;  2ZJQ S;  2ZJR S;  5GAH W;  1NYL A;  3CF5 S;  4IOC S;  5IZN A;  4H4K A;  3PIO S;  4JXX A;  1QRS A;  4JXZ A;  1DFU P;  2RE8 A;  5DM7 S;  4H3S A;  3PIP S;  2ZJP S;  5GAD W;  1O0C A;  4V19 4;  4WF9 S;  1FEU A;  4JYZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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