1T6PA

Crystal structure of phenylalanine ammonia lyase from rhodosporidium toruloides
Total Genus 228
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
228
sequence length
687
structure length
653
Chain Sequence
TNLAVAGSHLPTTQVTQVDIVEKMLAAPTDSTLELDGYSLNLGDVVSAARKGRPVRVKDSDEIRSKIDKSVEFLRSEDAISLQKALLEHQLCGVLPSSFDSFRLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRLVVLEALTNFLNHGITPIVPLRGTISDLSPLSYIAAAISGHPDSKVHVVHEGKEKILYAREAMALFNLEPVVLGPKEGLGLVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHPTQIEVAGNIRKLLEGSRFAVHHEEQDRYPLRTSPQWLGPLVSDLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTRLGLAQIGKLNFTQLTEMLNAGMNRGLPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMTGSNLRDELVEKVNKTLAKRLEQTNSYDLVPRWHDAFSFAAGTVVEVLSSTSLSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPRTQILYAFVREELGVKARRGDVFLGKQEVTIGSNVSKIYEAIKSGRINNVLLKMLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
pubmed doi rcsb
molecule tags Lyase
source organism Rhodosporidium toruloides
molecule keywords phenylalanine ammonia-lyase
total genus 228
structure length 653
sequence length 687
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.25: Phenylalanine/tyrosine ammonia-lyase.
pdb deposition date 2004-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1t6pA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1t6pA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1t6pA02
1W27A 2RJRA 4C5UA 1Y2MA 4BABA 4EFCA 1TJUA 2YIIA 2X75A 1FUQA 1B8FA 1FURA 2O7EA 1TJVA 4APAA 5F91A 2VD6A 2HVGA 1GK3A 1I0AA 2NYNA 4V2QA 3RD8A 3NZ4A 4FLCA 3KDZA 1K62A 4CQ5A 2O6YA 5F92A 2O7DA 4C5SA 4HGVA 4APBA 1XWOA 4ADMA 5EYTA 1FUOA 1DOFA 5EYVA 1T6PA 1JSWA 3KDYA 1RE5A 4NSLA 1C3CA 3CZOA 1TJ7A 4EEIA 5D6BA 2NYFA 2E9FA 2O7FA 3R6VA 1U16A 2FUSA 1DCNA 3R6YA 1GK2A 2PTQA 3NO9A 3E04A 3TV2A 4NLEA 4C5RA 1VDKA 1FUPA 3GTDA 2OHYA 2RJSA 1GKMA 4BAAA 4C6GA 1KQ7A 1Q5NA 1HY0A 1T6JA 3QBPA 4V2RA 1TJWA 3GZHA 4MX2A 2O7BA 1J3UA 3R6QA 3OCEA 2J91A 3C8TA 2PTSA 1GKJA 2PFMA 1K7WA 1U15A 3UNVA 4FFXA 2QGAB 1EB4A 1YISA 2O78A 1HY1A 1YFEA 1YFMA 3RRPA 5HW2A 2QVEA 1C3UA 2PTRA 3OCFA 4ADLA 1AUWA 3BHGA
chains in the Genus database with same CATH superfamily
1W27A 3GTGA 2FIOA 2X0PA 2RJRA 4QIWA 4C5UA 1TWGA 1Y2MA 3CRW1 3LRDA 5H8WA 4BABA 4EFCA 1TJUA 2E2HA 4CEIA 2YIIA 1Y1VA 2X75A 1TWAA 2MX8A 2N1DB 1FUQA 1TWHA 2LKMB 1B8FA 1K83A 1YNJD 1FURA 2O7EA 2A6HD 2LPIA 1TJVA 2JA5A 4APAA 2FENA 5F91A 3FKIA 2VD6A 2HVGA 3EZBA 1I3QA 1EZAA 2VK9A 1GK3A 1I0AA 2Y0NA 4V2QA 2NYNA 3RD8A 3NZ4A 4FLCA 3KDZA 5M0JA 2HWGA 2JA6A 1K62A 4CQ5A 1SMYD 3LR6A 2O6YA 1IW7D 5F92A 1WCMA 2X0QA 4FBSA 4C5SA 2O7DA 4HGVA 2AQLA 4APBA 1ZYMA 1XWOA 4ADMA 1XLYA 5EYTA 1I6VD 3GTMA 1FUOA 2HROA 2R92A 1T6PA 1DOFA 5EYVA 1JSWA 3KDYA 1I50A 3EZEA 1RE5A 3U4QA 4NSLA 1C3CA 3CZOA 2EZAA 1TJ7A 1TWFA 1XMDA 2JA7A 4EEIA 2VL7A 5D6BA 2NYFA 2K3QA 2N3EA 4WNLA 3LR2A 2E9FA 2O7FA 3R6VA 1U16A 2FUSA 1HQMD 2F5JA 3H0GA 1DCNA 3R6YA 1GK2A 2LTHA 1TWCA 2A69D 3GTPA 2PTQA 3NO9A 1XMCA 3E04A 3TV2A 4NLEA 4C5RA 2MP0A 3GTJA 2X0OA 1FUPA 1VDKA 2NVXA 2B63A 2EZCA 3GTDA 2OHYA 2RJSA 1GKMA 2YU9A 4BAAA 4C6GA 2LYIA 1KQ7A 2VSFA 1Q5NA 1HY0A 1T6JA 3QBPA 3U44A 1R9TA 1XL8A 4V2RA 3CRVA 1SFOA 2A68D 2FIPA 5M0IA 3GTQA 2A6ED 1TJWA 3GZHA 3GTLA 4MX2A 2R7ZA 2NVYA 4CEJA 3GTKA 2O7BA 1J3UA 3R6QA 5IZ2A 1YNND 3OCEA 1XL7A 2J91A 3C8TA 2PTSA 1GKJA 2PFMA 2BE5D 3GTOA 1K7WA 1U15A 3EZAA 3UNVA 4FFXA 1EZBA 2LPJA 3CQZA 2QGAB 1EB4A 2MX9A 2E2IA 1YISA 2O78A 1HY1A 1YFEA 2K3NA 2FELA 2VUMA 2K3OA 2R93A 1YFMA 2CW0D 3LR8A 3RRPA 5HW2A 2QVEA 4C2MA 1C3UA 2EZBA 2MQAA 2O5JD 4A15A 2PTRA 4CEHA 3OCFA 4ADLA 1AUWA 1ZYRD 1Y1WA 3BHGA
chains in the Genus database with same CATH topology
1W27A 2RJRA 4C5UA 1Y2MA 4BABA 4EFCA 1TJUA 2YIIA 2X75A 1FUQA 1B8FA 1FURA 2O7EA 1TJVA 4APAA 5F91A 2VD6A 2HVGA 1GK3A 1I0AA 2NYNA 4V2QA 3RD8A 3NZ4A 4FLCA 3KDZA 1K62A 4CQ5A 2O6YA 5F92A 2O7DA 4C5SA 4HGVA 4APBA 1XWOA 4ADMA 5EYTA 1FUOA 1DOFA 5EYVA 1T6PA 1JSWA 3KDYA 1RE5A 4NSLA 1C3CA 3CZOA 1TJ7A 4EEIA 5D6BA 2NYFA 2E9FA 2O7FA 3R6VA 1U16A 2FUSA 1DCNA 3R6YA 1GK2A 2PTQA 3NO9A 3E04A 3TV2A 4NLEA 4C5RA 1VDKA 1FUPA 3GTDA 2OHYA 2RJSA 1GKMA 4BAAA 4C6GA 1KQ7A 1Q5NA 1HY0A 1T6JA 3QBPA 4V2RA 1TJWA 3GZHA 4MX2A 2O7BA 1J3UA 3R6QA 3OCEA 2J91A 3C8TA 2PTSA 1GKJA 2PFMA 1K7WA 1U15A 3UNVA 4FFXA 2QGAB 1EB4A 1YISA 2O78A 1HY1A 1YFEA 1YFMA 3RRPA 5HW2A 2QVEA 1C3UA 2PTRA 3OCFA 4ADLA 1AUWA 3BHGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1W27 A;  2RJR A;  4C5U A;  1Y2M A;  4BAB A;  4EFC A;  1TJU A;  2YII A;  2X75 A;  1FUQ A;  1B8F A;  1FUR A;  2O7E A;  1TJV A;  4APA A;  5F91 A;  2VD6 A;  2HVG A;  1GK3 A;  1I0A A;  2NYN A;  4V2Q A;  3RD8 A;  3NZ4 A;  4FLC A;  3KDZ A;  1K62 A;  4CQ5 A;  2O6Y A;  5F92 A;  2O7D A;  4C5S A;  4HGV A;  4APB A;  1XWO A;  4ADM A;  5EYT A;  1FUO A;  1DOF A;  5EYV A;  1T6P A;  1JSW A;  3KDY A;  1RE5 A;  4NSL A;  1C3C A;  3CZO A;  1TJ7 A;  4EEI A;  5D6B A;  2NYF A;  2E9F A;  2O7F A;  3R6V A;  1U16 A;  2FUS A;  1DCN A;  3R6Y A;  1GK2 A;  2PTQ A;  3NO9 A;  3E04 A;  3TV2 A;  4NLE A;  4C5R A;  1VDK A;  1FUP A;  3GTD A;  2OHY A;  2RJS A;  1GKM A;  4BAA A;  4C6G A;  1KQ7 A;  1Q5N A;  1HY0 A;  1T6J A;  3QBP A;  4V2R A;  1TJW A;  3GZH A;  4MX2 A;  2O7B A;  1J3U A;  3R6Q A;  3OCE A;  2J91 A;  3C8T A;  2PTS A;  1GKJ A;  2PFM A;  1K7W A;  1U15 A;  3UNV A;  4FFX A;  2QGA B;  1EB4 A;  1YIS A;  2O78 A;  1HY1 A;  1YFE A;  1YFM A;  3RRP A;  5HW2 A;  2QVE A;  1C3U A;  2PTR A;  3OCF A;  4ADL A;  1AUW A;  3BHG A; 
#chains in the Genus database with same CATH topology
 1W27 A;  3GTG A;  2FIO A;  2X0P A;  2RJR A;  4QIW A;  4C5U A;  1TWG A;  1Y2M A;  3CRW 1;  3LRD A;  5H8W A;  4BAB A;  4EFC A;  1TJU A;  2E2H A;  4CEI A;  2YII A;  1Y1V A;  2X75 A;  1TWA A;  2MX8 A;  2N1D B;  1FUQ A;  1TWH A;  2LKM B;  1B8F A;  1K83 A;  1YNJ D;  1FUR A;  2O7E A;  2A6H D;  2LPI A;  1TJV A;  2JA5 A;  4APA A;  2FEN A;  5F91 A;  3FKI A;  2VD6 A;  2HVG A;  3EZB A;  1I3Q A;  1EZA A;  2VK9 A;  1GK3 A;  1I0A A;  2Y0N A;  4V2Q A;  2NYN A;  3RD8 A;  3NZ4 A;  4FLC A;  3KDZ A;  5M0J A;  2HWG A;  2JA6 A;  1K62 A;  4CQ5 A;  1SMY D;  3LR6 A;  2O6Y A;  1IW7 D;  5F92 A;  1WCM A;  2X0Q A;  4FBS A;  4C5S A;  2O7D A;  4HGV A;  2AQL A;  4APB A;  1ZYM A;  1XWO A;  4ADM A;  1XLY A;  5EYT A;  1I6V D;  3GTM A;  1FUO A;  2HRO A;  2R92 A;  1T6P A;  1DOF A;  5EYV A;  1JSW A;  3KDY A;  1I50 A;  3EZE A;  1RE5 A;  3U4Q A;  4NSL A;  1C3C A;  3CZO A;  2EZA A;  1TJ7 A;  1TWF A;  1XMD A;  2JA7 A;  4EEI A;  2VL7 A;  5D6B A;  2NYF A;  2K3Q A;  2N3E A;  4WNL A;  3LR2 A;  2E9F A;  2O7F A;  3R6V A;  1U16 A;  2FUS A;  1HQM D;  2F5J A;  3H0G A;  1DCN A;  3R6Y A;  1GK2 A;  2LTH A;  1TWC A;  2A69 D;  3GTP A;  2PTQ A;  3NO9 A;  1XMC A;  3E04 A;  3TV2 A;  4NLE A;  4C5R A;  2MP0 A;  3GTJ A;  2X0O A;  1FUP A;  1VDK A;  2NVX A;  2B63 A;  2EZC A;  3GTD A;  2OHY A;  2RJS A;  1GKM A;  2YU9 A;  4BAA A;  4C6G A;  2LYI A;  1KQ7 A;  2VSF A;  1Q5N A;  1HY0 A;  1T6J A;  3QBP A;  3U44 A;  1R9T A;  1XL8 A;  4V2R A;  3CRV A;  1SFO A;  2A68 D;  2FIP A;  5M0I A;  3GTQ A;  2A6E D;  1TJW A;  3GZH A;  3GTL A;  4MX2 A;  2R7Z A;  2NVY A;  4CEJ A;  3GTK A;  2O7B A;  1J3U A;  3R6Q A;  5IZ2 A;  1YNN D;  3OCE A;  1XL7 A;  2J91 A;  3C8T A;  2PTS A;  1GKJ A;  2PFM A;  2BE5 D;  3GTO A;  1K7W A;  1U15 A;  3EZA A;  3UNV A;  4FFX A;  1EZB A;  2LPJ A;  3CQZ A;  2QGA B;  1EB4 A;  2MX9 A;  2E2I A;  1YIS A;  2O78 A;  1HY1 A;  1YFE A;  2K3N A;  2FEL A;  2VUM A;  2K3O A;  2R93 A;  1YFM A;  2CW0 D;  3LR8 A;  3RRP A;  5HW2 A;  2QVE A;  4C2M A;  1C3U A;  2EZB A;  2MQA A;  2O5J D;  4A15 A;  2PTR A;  4CEH A;  3OCF A;  4ADL A;  1AUW A;  1ZYR D;  1Y1W A;  3BHG A; 
#chains in the Genus database with same CATH homology
 1W27 A;  2RJR A;  4C5U A;  1Y2M A;  4BAB A;  4EFC A;  1TJU A;  2YII A;  2X75 A;  1FUQ A;  1B8F A;  1FUR A;  2O7E A;  1TJV A;  4APA A;  5F91 A;  2VD6 A;  2HVG A;  1GK3 A;  1I0A A;  2NYN A;  4V2Q A;  3RD8 A;  3NZ4 A;  4FLC A;  3KDZ A;  1K62 A;  4CQ5 A;  2O6Y A;  5F92 A;  2O7D A;  4C5S A;  4HGV A;  4APB A;  1XWO A;  4ADM A;  5EYT A;  1FUO A;  1DOF A;  5EYV A;  1T6P A;  1JSW A;  3KDY A;  1RE5 A;  4NSL A;  1C3C A;  3CZO A;  1TJ7 A;  4EEI A;  5D6B A;  2NYF A;  2E9F A;  2O7F A;  3R6V A;  1U16 A;  2FUS A;  1DCN A;  3R6Y A;  1GK2 A;  2PTQ A;  3NO9 A;  3E04 A;  3TV2 A;  4NLE A;  4C5R A;  1VDK A;  1FUP A;  3GTD A;  2OHY A;  2RJS A;  1GKM A;  4BAA A;  4C6G A;  1KQ7 A;  1Q5N A;  1HY0 A;  1T6J A;  3QBP A;  4V2R A;  1TJW A;  3GZH A;  4MX2 A;  2O7B A;  1J3U A;  3R6Q A;  3OCE A;  2J91 A;  3C8T A;  2PTS A;  1GKJ A;  2PFM A;  1K7W A;  1U15 A;  3UNV A;  4FFX A;  2QGA B;  1EB4 A;  1YIS A;  2O78 A;  1HY1 A;  1YFE A;  1YFM A;  3RRP A;  5HW2 A;  2QVE A;  1C3U A;  2PTR A;  3OCF A;  4ADL A;  1AUW A;  3BHG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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