1T6PA

Crystal structure of phenylalanine ammonia lyase from rhodosporidium toruloides
Total Genus 228
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
228
sequence length
687
structure length
653
Chain Sequence
TNLAVAGSHLPTTQVTQVDIVEKMLAAPTDSTLELDGYSLNLGDVVSAARKGRPVRVKDSDEIRSKIDKSVEFLRSEDAISLQKALLEHQLCGVLPSSFDSFRLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRLVVLEALTNFLNHGITPIVPLRGTISDLSPLSYIAAAISGHPDSKVHVVHEGKEKILYAREAMALFNLEPVVLGPKEGLGLVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHPTQIEVAGNIRKLLEGSRFAVHHEEQDRYPLRTSPQWLGPLVSDLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTRLGLAQIGKLNFTQLTEMLNAGMNRGLPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMTGSNLRDELVEKVNKTLAKRLEQTNSYDLVPRWHDAFSFAAGTVVEVLSSTSLSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPRTQILYAFVREELGVKARRGDVFLGKQEVTIGSNVSKIYEAIKSGRINNVLLKMLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
pubmed doi rcsb
molecule tags Lyase
source organism Rhodosporidium toruloides
molecule keywords phenylalanine ammonia-lyase
total genus 228
structure length 653
sequence length 687
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.25: Phenylalanine/tyrosine ammonia-lyase.
pdb deposition date 2004-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1t6pA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1t6pA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1t6pA02
4C5RA 2FUSA 2NYFA 2PTRA 3TV2A 4C5UA 3BHGA 1DOFA 3R6VA 1XWOA 1C3UA 5EYTA 4NSLA 4EEIA 2QGAB 4V2QA 3OCFA 3KDYA 4BABA 2VD6A 3NO9A 1DCNA 2PTSA 2HVGA 1RE5A 3R6YA 2O7EA 3KDZA 3E04A 1HY0A 2O7BA 1T6JA 2QVEA 1U16A 4CQ5A 1Y2MA 3UNVA 1K7WA 1TJUA 2YIIA 4FFXA 1FURA 4V2RA 5F91A 3GTDA 5F92A 1C3CA 2O7FA 3C8TA 1K62A 4ADLA 5D6BA 1TJVA 5HW2A 1FUQA 4MX2A 4ADMA 1HY1A 2O6YA 1Q5NA 4C5SA 1FUOA 1U15A 2RJSA 1FUPA 2NYNA 1GKMA 3QBPA 1I0AA 3GZHA 1GK2A 1YFMA 2E9FA 1YFEA 4HGVA 2OHYA 2O7DA 1B8FA 1W27A 4EFCA 3OCEA 1TJ7A 2O78A 1VDKA 1T6PA 2RJRA 1YISA 5EYVA 4FLCA 1EB4A 1KQ7A 2X75A 4APBA 3NZ4A 1GK3A 4APAA 1GKJA 4NLEA 1JSWA 1TJWA 4C6GA 3RRPA 3CZOA 2PTQA 3RD8A 1AUWA 1J3UA 2PFMA 3R6QA 4BAAA 2J91A
chains in the Genus database with same CATH superfamily
2O5JD 3U4QA 4C2MA 2LTHA 3LRDA 4C5RA 2VUMA 2FUSA 2J91A 2NYFA 2PTRA 2VSFA 3TV2A 2X0PA 4C5UA 2LPJA 3BHGA 4WNLA 1XMDA 1XLYA 1DOFA 2R92A 3R6VA 1XWOA 1C3UA 2Y0NA 5H8WA 5EYTA 3FKIA 4NSLA 4EEIA 1TWGA 3LR6A 2K3OA 2QGAB 2FELA 4V2QA 3OCFA 3KDYA 1HQMD 4BABA 2N1DB 1TWCA 2VD6A 2NVYA 2MX8A 2FENA 3NO9A 2K3NA 2N3EA 1DCNA 2PTSA 1XL8A 4CEJA 2LKMB 1I50A 5M0IA 5IZ2A 2F5JA 2LYIA 1RE5A 3GTQA 2HVGA 1TWAA 2HWGA 2R7ZA 3R6YA 3GTPA 1ZYRD 2O7EA 2LPIA 1I3QA 3KDZA 3E04A 1HY0A 2O7BA 1T6JA 4FBSA 2YU9A 1SFOA 2QVEA 1U16A 1EZBA 4CQ5A 1Y2MA 3UNVA 1K7WA 3EZAA 1XMCA 1TJUA 2X0OA 2YIIA 2X0QA 2MX9A 4FFXA 3CRVA 1FURA 1YNJD 2EZAA 4V2RA 1I6VD 2HROA 2JA5A 2JA7A 3GTLA 3GTDA 5F91A 2E2IA 2K3QA 5F92A 1SMYD 1C3CA 2MQAA 2O7FA 3GTJA 3C8TA 1IW7D 2A69D 1K83A 4ADLA 2EZBA 5D6BA 1TJVA 2FIPA 3GTOA 5HW2A 1FUQA 4MX2A 4ADMA 2A68D 3GTKA 3GTMA 2NVXA 1HY1A 4C5SA 1FUOA 1Q5NA 2FIOA 1U15A 2O6YA 2RJSA 3LR8A 1FUPA 2NYNA 2EZCA 1R9TA 1GKMA 4CEHA 3QBPA 2CW0D 1I0AA 3GZHA 1TWHA 1GK2A 1ZYMA 1YFMA 1Y1VA 1EZAA 2E9FA 2A6HD 3LR2A 1WCMA 3U44A 1YFEA 4HGVA 2OHYA 5M0JA 2O7DA 1B8FA 1W27A 4EFCA 3OCEA 1TJ7A 4A15A 3CQZA 2O78A 1VDKA 2B63A 1T6PA 2RJRA 1YISA 3CRW1 1YNND 5EYVA 2BE5D 2A6ED 2R93A 2VL7A 2VK9A 1EB4A 4FLCA 1KQ7A 2X75A 3EZEA 4APBA 3NZ4A 1GK3A 4NLEA 1GKJA 4APAA 1JSWA 3GTGA 1TJWA 4C6GA 4QIWA 2E2HA 3RRPA 2AQLA 4CEIA 3CZOA 2PTQA 3RD8A 1TWFA 1XL7A 2MP0A 2JA6A 3EZBA 1AUWA 1J3UA 2PFMA 3R6QA 4BAAA 3H0GA 1Y1WA 1K62A
chains in the Genus database with same CATH topology
4C5RA 2FUSA 2NYFA 2PTRA 3TV2A 4C5UA 3BHGA 1DOFA 3R6VA 1XWOA 1C3UA 5EYTA 4NSLA 4EEIA 2QGAB 4V2QA 3OCFA 3KDYA 4BABA 2VD6A 3NO9A 1DCNA 2PTSA 2HVGA 1RE5A 3R6YA 2O7EA 3KDZA 3E04A 1HY0A 2O7BA 1T6JA 2QVEA 1U16A 4CQ5A 1Y2MA 3UNVA 1K7WA 1TJUA 2YIIA 4FFXA 1FURA 4V2RA 5F91A 3GTDA 5F92A 1C3CA 2O7FA 3C8TA 1K62A 4ADLA 5D6BA 1TJVA 5HW2A 1FUQA 4MX2A 4ADMA 1HY1A 2O6YA 1Q5NA 4C5SA 1FUOA 1U15A 2RJSA 1FUPA 2NYNA 1GKMA 3QBPA 1I0AA 3GZHA 1GK2A 1YFMA 2E9FA 1YFEA 4HGVA 2OHYA 2O7DA 1B8FA 1W27A 4EFCA 3OCEA 1TJ7A 2O78A 1VDKA 1T6PA 2RJRA 1YISA 5EYVA 4FLCA 1EB4A 1KQ7A 2X75A 4APBA 3NZ4A 1GK3A 4APAA 1GKJA 4NLEA 1JSWA 1TJWA 4C6GA 3RRPA 3CZOA 2PTQA 3RD8A 1AUWA 1J3UA 2PFMA 3R6QA 4BAAA 2J91A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4C5R A;  2FUS A;  2NYF A;  2PTR A;  3TV2 A;  4C5U A;  3BHG A;  1DOF A;  3R6V A;  1XWO A;  1C3U A;  5EYT A;  4NSL A;  4EEI A;  2QGA B;  4V2Q A;  3OCF A;  3KDY A;  4BAB A;  2VD6 A;  3NO9 A;  1DCN A;  2PTS A;  2HVG A;  1RE5 A;  3R6Y A;  2O7E A;  3KDZ A;  3E04 A;  1HY0 A;  2O7B A;  1T6J A;  2QVE A;  1U16 A;  4CQ5 A;  1Y2M A;  3UNV A;  1K7W A;  1TJU A;  2YII A;  4FFX A;  1FUR A;  4V2R A;  5F91 A;  3GTD A;  5F92 A;  1C3C A;  2O7F A;  3C8T A;  1K62 A;  4ADL A;  5D6B A;  1TJV A;  5HW2 A;  1FUQ A;  4MX2 A;  4ADM A;  1HY1 A;  2O6Y A;  1Q5N A;  4C5S A;  1FUO A;  1U15 A;  2RJS A;  1FUP A;  2NYN A;  1GKM A;  3QBP A;  1I0A A;  3GZH A;  1GK2 A;  1YFM A;  2E9F A;  1YFE A;  4HGV A;  2OHY A;  2O7D A;  1B8F A;  1W27 A;  4EFC A;  3OCE A;  1TJ7 A;  2O78 A;  1VDK A;  1T6P A;  2RJR A;  1YIS A;  5EYV A;  4FLC A;  1EB4 A;  1KQ7 A;  2X75 A;  4APB A;  3NZ4 A;  1GK3 A;  4APA A;  1GKJ A;  4NLE A;  1JSW A;  1TJW A;  4C6G A;  3RRP A;  3CZO A;  2PTQ A;  3RD8 A;  1AUW A;  1J3U A;  2PFM A;  3R6Q A;  4BAA A;  2J91 A; 
#chains in the Genus database with same CATH topology
 2O5J D;  3U4Q A;  4C2M A;  2LTH A;  3LRD A;  4C5R A;  2VUM A;  2FUS A;  2J91 A;  2NYF A;  2PTR A;  2VSF A;  3TV2 A;  2X0P A;  4C5U A;  2LPJ A;  3BHG A;  4WNL A;  1XMD A;  1XLY A;  1DOF A;  2R92 A;  3R6V A;  1XWO A;  1C3U A;  2Y0N A;  5H8W A;  5EYT A;  3FKI A;  4NSL A;  4EEI A;  1TWG A;  3LR6 A;  2K3O A;  2QGA B;  2FEL A;  4V2Q A;  3OCF A;  3KDY A;  1HQM D;  4BAB A;  2N1D B;  1TWC A;  2VD6 A;  2NVY A;  2MX8 A;  2FEN A;  3NO9 A;  2K3N A;  2N3E A;  1DCN A;  2PTS A;  1XL8 A;  4CEJ A;  2LKM B;  1I50 A;  5M0I A;  5IZ2 A;  2F5J A;  2LYI A;  1RE5 A;  3GTQ A;  2HVG A;  1TWA A;  2HWG A;  2R7Z A;  3R6Y A;  3GTP A;  1ZYR D;  2O7E A;  2LPI A;  1I3Q A;  3KDZ A;  3E04 A;  1HY0 A;  2O7B A;  1T6J A;  4FBS A;  2YU9 A;  1SFO A;  2QVE A;  1U16 A;  1EZB A;  4CQ5 A;  1Y2M A;  3UNV A;  1K7W A;  3EZA A;  1XMC A;  1TJU A;  2X0O A;  2YII A;  2X0Q A;  2MX9 A;  4FFX A;  3CRV A;  1FUR A;  1YNJ D;  2EZA A;  4V2R A;  1I6V D;  2HRO A;  2JA5 A;  2JA7 A;  3GTL A;  3GTD A;  5F91 A;  2E2I A;  2K3Q A;  5F92 A;  1SMY D;  1C3C A;  2MQA A;  2O7F A;  3GTJ A;  3C8T A;  1IW7 D;  2A69 D;  1K83 A;  4ADL A;  2EZB A;  5D6B A;  1TJV A;  2FIP A;  3GTO A;  5HW2 A;  1FUQ A;  4MX2 A;  4ADM A;  2A68 D;  3GTK A;  3GTM A;  2NVX A;  1HY1 A;  4C5S A;  1FUO A;  1Q5N A;  2FIO A;  1U15 A;  2O6Y A;  2RJS A;  3LR8 A;  1FUP A;  2NYN A;  2EZC A;  1R9T A;  1GKM A;  4CEH A;  3QBP A;  2CW0 D;  1I0A A;  3GZH A;  1TWH A;  1GK2 A;  1ZYM A;  1YFM A;  1Y1V A;  1EZA A;  2E9F A;  2A6H D;  3LR2 A;  1WCM A;  3U44 A;  1YFE A;  4HGV A;  2OHY A;  5M0J A;  2O7D A;  1B8F A;  1W27 A;  4EFC A;  3OCE A;  1TJ7 A;  4A15 A;  3CQZ A;  2O78 A;  1VDK A;  2B63 A;  1T6P A;  2RJR A;  1YIS A;  3CRW 1;  1YNN D;  5EYV A;  2BE5 D;  2A6E D;  2R93 A;  2VL7 A;  2VK9 A;  1EB4 A;  4FLC A;  1KQ7 A;  2X75 A;  3EZE A;  4APB A;  3NZ4 A;  1GK3 A;  4NLE A;  1GKJ A;  4APA A;  1JSW A;  3GTG A;  1TJW A;  4C6G A;  4QIW A;  2E2H A;  3RRP A;  2AQL A;  4CEI A;  3CZO A;  2PTQ A;  3RD8 A;  1TWF A;  1XL7 A;  2MP0 A;  2JA6 A;  3EZB A;  1AUW A;  1J3U A;  2PFM A;  3R6Q A;  4BAA A;  3H0G A;  1Y1W A;  1K62 A; 
#chains in the Genus database with same CATH homology
 4C5R A;  2FUS A;  2NYF A;  2PTR A;  3TV2 A;  4C5U A;  3BHG A;  1DOF A;  3R6V A;  1XWO A;  1C3U A;  5EYT A;  4NSL A;  4EEI A;  2QGA B;  4V2Q A;  3OCF A;  3KDY A;  4BAB A;  2VD6 A;  3NO9 A;  1DCN A;  2PTS A;  2HVG A;  1RE5 A;  3R6Y A;  2O7E A;  3KDZ A;  3E04 A;  1HY0 A;  2O7B A;  1T6J A;  2QVE A;  1U16 A;  4CQ5 A;  1Y2M A;  3UNV A;  1K7W A;  1TJU A;  2YII A;  4FFX A;  1FUR A;  4V2R A;  5F91 A;  3GTD A;  5F92 A;  1C3C A;  2O7F A;  3C8T A;  1K62 A;  4ADL A;  5D6B A;  1TJV A;  5HW2 A;  1FUQ A;  4MX2 A;  4ADM A;  1HY1 A;  2O6Y A;  1Q5N A;  4C5S A;  1FUO A;  1U15 A;  2RJS A;  1FUP A;  2NYN A;  1GKM A;  3QBP A;  1I0A A;  3GZH A;  1GK2 A;  1YFM A;  2E9F A;  1YFE A;  4HGV A;  2OHY A;  2O7D A;  1B8F A;  1W27 A;  4EFC A;  3OCE A;  1TJ7 A;  2O78 A;  1VDK A;  1T6P A;  2RJR A;  1YIS A;  5EYV A;  4FLC A;  1EB4 A;  1KQ7 A;  2X75 A;  4APB A;  3NZ4 A;  1GK3 A;  4APA A;  1GKJ A;  4NLE A;  1JSW A;  1TJW A;  4C6G A;  3RRP A;  3CZO A;  2PTQ A;  3RD8 A;  1AUW A;  1J3U A;  2PFM A;  3R6Q A;  4BAA A;  2J91 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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