1T6PA

Crystal structure of phenylalanine ammonia lyase from rhodosporidium toruloides
Total Genus 228
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
228
sequence length
687
structure length
653
Chain Sequence
TNLAVAGSHLPTTQVTQVDIVEKMLAAPTDSTLELDGYSLNLGDVVSAARKGRPVRVKDSDEIRSKIDKSVEFLRSEDAISLQKALLEHQLCGVLPSSFDSFRLGRGLENSLPLEVVRGAMTIRVNSLTRGHSAVRLVVLEALTNFLNHGITPIVPLRGTISDLSPLSYIAAAISGHPDSKVHVVHEGKEKILYAREAMALFNLEPVVLGPKEGLGLVNGTAVSASMATLALHDAHMLSLLSQSLTAMTVEAMVGHAGSFHPFLHDVTRPHPTQIEVAGNIRKLLEGSRFAVHHEEQDRYPLRTSPQWLGPLVSDLIHAHAVLTIEAGQSTTDNPLIDVENKTSHHGGNFQAAAVANTMEKTRLGLAQIGKLNFTQLTEMLNAGMNRGLPSCLAAEDPSLSYHCKGLDIAAAAYTSELGHLANPVTTHVQPAEMANQAVNSLALISARRTTESNDVLSLLLATHLYCVLQAIDLRAIEFEFKKQFGPAIVSLIDQHFGSAMTGSNLRDELVEKVNKTLAKRLEQTNSYDLVPRWHDAFSFAAGTVVEVLSSTSLSLAAVNAWKVAAAESAISLTRQVRETFWSAASTSSPALSYLSPRTQILYAFVREELGVKARRGDVFLGKQEVTIGSNVSKIYEAIKSGRINNVLLKMLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
pubmed doi rcsb
molecule tags Lyase
source organism Rhodosporidium toruloides
molecule keywords phenylalanine ammonia-lyase
total genus 228
structure length 653
sequence length 687
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 4.3.1.25: Phenylalanine/tyrosine ammonia-lyase.
pdb deposition date 2004-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1t6pA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1t6pA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1t6pA02
1C3CA 1T6PA 5F92A 3OCEA 4V2QA 1EB4A 1GK2A 2E9FA 3NZ4A 1FUOA 1Y2MA 1I0AA 4MX2A 3C8TA 4BAAA 1B8FA 4C5RA 1DOFA 2RJSA 2OHYA 2FUSA 4FLCA 3TV2A 1YISA 1FURA 1J3UA 3CZOA 5F91A 1YFEA 4EEIA 4APAA 2VD6A 4APBA 1U16A 3NO9A 3RRPA 1TJUA 3BHGA 2X75A 4FFXA 2YIIA 2PTSA 2PTRA 2QVEA 3R6VA 2O7EA 1GK3A 3KDZA 1FUQA 2O6YA 5EYVA 1K7WA 3GZHA 2O7DA 4C5SA 3R6YA 4EFCA 2NYNA 1T6JA 4NLEA 4ADMA 2QGAB 3KDYA 1XWOA 2J91A 4HGVA 3R6QA 1HY1A 1YFMA 2O7FA 3GTDA 3OCFA 4C6GA 4NSLA 2O78A 2NYFA 5EYTA 3UNVA 4C5UA 2PFMA 4ADLA 1HY0A 4CQ5A 3RD8A 1GKJA 1GKMA 1W27A 1RE5A 2PTQA 1KQ7A 1FUPA 2O7BA 1VDKA 3E04A 1DCNA 1JSWA 4BABA 1AUWA 3QBPA 1TJWA 1C3UA 1TJ7A 1Q5NA 5HW2A 5D6BA 1K62A 4V2RA 2RJRA 2HVGA 1TJVA 1U15A
chains in the Genus database with same CATH superfamily
1C3CA 2N1DB 1T6PA 1I50A 5F92A 5H8WA 1ZYRD 3OCEA 1WCMA 4V2QA 2A68D 2X0QA 3LRDA 1SFOA 2NVXA 2HROA 2LPIA 1EB4A 1GK2A 3LR8A 2E9FA 2HVGA 3NZ4A 2HWGA 1FUOA 1Y2MA 1I0AA 2VSFA 1EZBA 2FELA 4MX2A 4CEJA 3GTMA 3C8TA 1TWHA 4BAAA 2R7ZA 3EZAA 2JA7A 2CW0D 1B8FA 1XMCA 3CRVA 2BE5D 2AQLA 4C5RA 1TJVA 1DOFA 2RJSA 1R9TA 2R92A 2OHYA 2FUSA 4FLCA 3TV2A 1YISA 1FURA 3GTKA 2LYIA 1J3UA 3CZOA 2F5JA 5F91A 2EZBA 2N3EA 3EZEA 2Y0NA 2A6ED 2MX8A 4A15A 4QIWA 3CQZA 1YFEA 2NVYA 4CEIA 4EEIA 1HQMD 2VD6A 4APAA 1U16A 4APBA 2A6HD 3NO9A 3RRPA 1TJUA 3BHGA 1YNJD 2K3QA 1ZYMA 1K83A 3LR2A 2X75A 3U44A 4FFXA 2MQAA 2YIIA 2PTSA 2PTRA 2QVEA 3R6VA 1EZAA 2O7EA 1GK3A 3KDZA 4FBSA 1FUQA 2O6YA 5EYVA 2VUMA 1K7WA 3CRW1 3H0GA 3GZHA 2FENA 1XLYA 2O7DA 4C5SA 3R6YA 4EFCA 3GTLA 5M0JA 3U4QA 1T6JA 2JA5A 2NYNA 4NLEA 3GTGA 2E2HA 2E2IA 3GTPA 1TWCA 1TWFA 5IZ2A 2R93A 1I6VD 2EZAA 4ADMA 2QGAB 3KDYA 2MX9A 1XWOA 3FKIA 2J91A 4HGVA 5M0IA 3R6QA 1HY1A 1YFMA 2O7FA 1SMYD 3GTDA 4C6GA 3OCFA 2O78A 2NYFA 4NSLA 5EYTA 3UNVA 4C5UA 2EZCA 2PFMA 4ADLA 1HY0A 2K3NA 2K3OA 4CQ5A 3GTOA 2JA6A 2X0PA 3RD8A 2VL7A 1GKJA 1GKMA 1XL7A 2LPJA 1TWGA 1I3QA 3EZBA 2FIPA 1W27A 1RE5A 2PTQA 1KQ7A 1XMDA 3LR6A 2LTHA 1FUPA 2O7BA 2B63A 2VK9A 1VDKA 3E04A 3GTJA 3GTQA 1DCNA 1JSWA 4BABA 4WNLA 1Y1VA 1TWAA 1AUWA 3QBPA 1TJWA 2MP0A 1C3UA 1TJ7A 1XL8A 4CEHA 2O5JD 1Q5NA 5HW2A 5D6BA 1Y1WA 1YNND 1IW7D 2X0OA 2FIOA 1K62A 4V2RA 2YU9A 2A69D 2LKMB 4C2MA 2RJRA 1U15A
chains in the Genus database with same CATH topology
1C3CA 1T6PA 5F92A 3OCEA 4V2QA 1EB4A 1GK2A 2E9FA 3NZ4A 1FUOA 1Y2MA 1I0AA 4MX2A 3C8TA 4BAAA 1B8FA 4C5RA 1DOFA 2RJSA 2OHYA 2FUSA 4FLCA 3TV2A 1YISA 1FURA 1J3UA 3CZOA 5F91A 1YFEA 4EEIA 4APAA 2VD6A 4APBA 1U16A 3NO9A 3RRPA 1TJUA 3BHGA 2X75A 4FFXA 2YIIA 2PTSA 2PTRA 2QVEA 3R6VA 2O7EA 1GK3A 3KDZA 1FUQA 2O6YA 5EYVA 1K7WA 3GZHA 2O7DA 4C5SA 3R6YA 4EFCA 2NYNA 1T6JA 4NLEA 4ADMA 2QGAB 3KDYA 1XWOA 2J91A 4HGVA 3R6QA 1HY1A 1YFMA 2O7FA 3GTDA 3OCFA 4C6GA 4NSLA 2O78A 2NYFA 5EYTA 3UNVA 4C5UA 2PFMA 4ADLA 1HY0A 4CQ5A 3RD8A 1GKJA 1GKMA 1W27A 1RE5A 2PTQA 1KQ7A 1FUPA 2O7BA 1VDKA 3E04A 1DCNA 1JSWA 4BABA 1AUWA 3QBPA 1TJWA 1C3UA 1TJ7A 1Q5NA 5HW2A 5D6BA 1K62A 4V2RA 2RJRA 2HVGA 1TJVA 1U15A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C3C A;  1T6P A;  5F92 A;  3OCE A;  4V2Q A;  1EB4 A;  1GK2 A;  2E9F A;  3NZ4 A;  1FUO A;  1Y2M A;  1I0A A;  4MX2 A;  3C8T A;  4BAA A;  1B8F A;  4C5R A;  1DOF A;  2RJS A;  2OHY A;  2FUS A;  4FLC A;  3TV2 A;  1YIS A;  1FUR A;  1J3U A;  3CZO A;  5F91 A;  1YFE A;  4EEI A;  4APA A;  2VD6 A;  4APB A;  1U16 A;  3NO9 A;  3RRP A;  1TJU A;  3BHG A;  2X75 A;  4FFX A;  2YII A;  2PTS A;  2PTR A;  2QVE A;  3R6V A;  2O7E A;  1GK3 A;  3KDZ A;  1FUQ A;  2O6Y A;  5EYV A;  1K7W A;  3GZH A;  2O7D A;  4C5S A;  3R6Y A;  4EFC A;  2NYN A;  1T6J A;  4NLE A;  4ADM A;  2QGA B;  3KDY A;  1XWO A;  2J91 A;  4HGV A;  3R6Q A;  1HY1 A;  1YFM A;  2O7F A;  3GTD A;  3OCF A;  4C6G A;  4NSL A;  2O78 A;  2NYF A;  5EYT A;  3UNV A;  4C5U A;  2PFM A;  4ADL A;  1HY0 A;  4CQ5 A;  3RD8 A;  1GKJ A;  1GKM A;  1W27 A;  1RE5 A;  2PTQ A;  1KQ7 A;  1FUP A;  2O7B A;  1VDK A;  3E04 A;  1DCN A;  1JSW A;  4BAB A;  1AUW A;  3QBP A;  1TJW A;  1C3U A;  1TJ7 A;  1Q5N A;  5HW2 A;  5D6B A;  1K62 A;  4V2R A;  2RJR A;  2HVG A;  1TJV A;  1U15 A; 
#chains in the Genus database with same CATH topology
 1C3C A;  2N1D B;  1T6P A;  1I50 A;  5F92 A;  5H8W A;  1ZYR D;  3OCE A;  1WCM A;  4V2Q A;  2A68 D;  2X0Q A;  3LRD A;  1SFO A;  2NVX A;  2HRO A;  2LPI A;  1EB4 A;  1GK2 A;  3LR8 A;  2E9F A;  2HVG A;  3NZ4 A;  2HWG A;  1FUO A;  1Y2M A;  1I0A A;  2VSF A;  1EZB A;  2FEL A;  4MX2 A;  4CEJ A;  3GTM A;  3C8T A;  1TWH A;  4BAA A;  2R7Z A;  3EZA A;  2JA7 A;  2CW0 D;  1B8F A;  1XMC A;  3CRV A;  2BE5 D;  2AQL A;  4C5R A;  1TJV A;  1DOF A;  2RJS A;  1R9T A;  2R92 A;  2OHY A;  2FUS A;  4FLC A;  3TV2 A;  1YIS A;  1FUR A;  3GTK A;  2LYI A;  1J3U A;  3CZO A;  2F5J A;  5F91 A;  2EZB A;  2N3E A;  3EZE A;  2Y0N A;  2A6E D;  2MX8 A;  4A15 A;  4QIW A;  3CQZ A;  1YFE A;  2NVY A;  4CEI A;  4EEI A;  1HQM D;  2VD6 A;  4APA A;  1U16 A;  4APB A;  2A6H D;  3NO9 A;  3RRP A;  1TJU A;  3BHG A;  1YNJ D;  2K3Q A;  1ZYM A;  1K83 A;  3LR2 A;  2X75 A;  3U44 A;  4FFX A;  2MQA A;  2YII A;  2PTS A;  2PTR A;  2QVE A;  3R6V A;  1EZA A;  2O7E A;  1GK3 A;  3KDZ A;  4FBS A;  1FUQ A;  2O6Y A;  5EYV A;  2VUM A;  1K7W A;  3CRW 1;  3H0G A;  3GZH A;  2FEN A;  1XLY A;  2O7D A;  4C5S A;  3R6Y A;  4EFC A;  3GTL A;  5M0J A;  3U4Q A;  1T6J A;  2JA5 A;  2NYN A;  4NLE A;  3GTG A;  2E2H A;  2E2I A;  3GTP A;  1TWC A;  1TWF A;  5IZ2 A;  2R93 A;  1I6V D;  2EZA A;  4ADM A;  2QGA B;  3KDY A;  2MX9 A;  1XWO A;  3FKI A;  2J91 A;  4HGV A;  5M0I A;  3R6Q A;  1HY1 A;  1YFM A;  2O7F A;  1SMY D;  3GTD A;  4C6G A;  3OCF A;  2O78 A;  2NYF A;  4NSL A;  5EYT A;  3UNV A;  4C5U A;  2EZC A;  2PFM A;  4ADL A;  1HY0 A;  2K3N A;  2K3O A;  4CQ5 A;  3GTO A;  2JA6 A;  2X0P A;  3RD8 A;  2VL7 A;  1GKJ A;  1GKM A;  1XL7 A;  2LPJ A;  1TWG A;  1I3Q A;  3EZB A;  2FIP A;  1W27 A;  1RE5 A;  2PTQ A;  1KQ7 A;  1XMD A;  3LR6 A;  2LTH A;  1FUP A;  2O7B A;  2B63 A;  2VK9 A;  1VDK A;  3E04 A;  3GTJ A;  3GTQ A;  1DCN A;  1JSW A;  4BAB A;  4WNL A;  1Y1V A;  1TWA A;  1AUW A;  3QBP A;  1TJW A;  2MP0 A;  1C3U A;  1TJ7 A;  1XL8 A;  4CEH A;  2O5J D;  1Q5N A;  5HW2 A;  5D6B A;  1Y1W A;  1YNN D;  1IW7 D;  2X0O A;  2FIO A;  1K62 A;  4V2R A;  2YU9 A;  2A69 D;  2LKM B;  4C2M A;  2RJR A;  1U15 A; 
#chains in the Genus database with same CATH homology
 1C3C A;  1T6P A;  5F92 A;  3OCE A;  4V2Q A;  1EB4 A;  1GK2 A;  2E9F A;  3NZ4 A;  1FUO A;  1Y2M A;  1I0A A;  4MX2 A;  3C8T A;  4BAA A;  1B8F A;  4C5R A;  1DOF A;  2RJS A;  2OHY A;  2FUS A;  4FLC A;  3TV2 A;  1YIS A;  1FUR A;  1J3U A;  3CZO A;  5F91 A;  1YFE A;  4EEI A;  4APA A;  2VD6 A;  4APB A;  1U16 A;  3NO9 A;  3RRP A;  1TJU A;  3BHG A;  2X75 A;  4FFX A;  2YII A;  2PTS A;  2PTR A;  2QVE A;  3R6V A;  2O7E A;  1GK3 A;  3KDZ A;  1FUQ A;  2O6Y A;  5EYV A;  1K7W A;  3GZH A;  2O7D A;  4C5S A;  3R6Y A;  4EFC A;  2NYN A;  1T6J A;  4NLE A;  4ADM A;  2QGA B;  3KDY A;  1XWO A;  2J91 A;  4HGV A;  3R6Q A;  1HY1 A;  1YFM A;  2O7F A;  3GTD A;  3OCF A;  4C6G A;  4NSL A;  2O78 A;  2NYF A;  5EYT A;  3UNV A;  4C5U A;  2PFM A;  4ADL A;  1HY0 A;  4CQ5 A;  3RD8 A;  1GKJ A;  1GKM A;  1W27 A;  1RE5 A;  2PTQ A;  1KQ7 A;  1FUP A;  2O7B A;  1VDK A;  3E04 A;  1DCN A;  1JSW A;  4BAB A;  1AUW A;  3QBP A;  1TJW A;  1C3U A;  1TJ7 A;  1Q5N A;  5HW2 A;  5D6B A;  1K62 A;  4V2R A;  2RJR A;  2HVG A;  1TJV A;  1U15 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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