1W27A

Phenylalanine ammonia-lyase (pal) from petroselinum crispum
Total Genus 254
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
254
sequence length
690
structure length
689
Chain Sequence
EDPLYWGIAAEAMTGSHLDEVKKMVAEYRKPVVKLGGETLTISQVAAISARDGSGVTVELSEAARAGVKASSDWVMDSMNKGTDSYGVTTGFGATSHRRTKQGGALQKELIRFLNAGIFGNGSDNTLPHSATRAAMLVRINTLLQGYSGIRFEILEAITKFLNQNITPCLPLRGTITDLVPLSYIAGLLTGRPNSKAVGPTGVILSPEEAFKLAGVEGGFFELQPKEGLALVNGTAVGSGMASMVLFEANILAVLAEVMSAIFAEVMQGKPEFTDHLTHKLKHHPGQIEAAAIMEHILDGSAYVKAAQKLHEMDPLQKPKQDRYALRTSPQWLGPQIEVIRSSTKMIEREINSVNDNPLIDVSRNKAIHGGNFQGTPIGVSMDNTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNLSGGRNPSLDYGFKGAEIAMASYCSELQFLANPVTNHVQSAEQHNQDVNSLGLISSRKTSEAVEILKLMSTTFLVGLCQAIDLRHLEENLKSTVKNTVSSVAKRVLTMGVNGELHPSRFCEKDLLRVVDREYIFAYIDDPCSATYPLMQKLRQTLVEHALKNGDNERNLSTSIFQKIATFEDELKALLPKEVESARAALESGNPAIPNRIEECRSYPLYKFVRKELGTEYLTGEKVTSPGEEFEKVFIAMSKGEIIDPLLECLESWNGAPLPIC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for the Entrance Into the Phenylpropanoid Metabolism Catalyzed by Phenylalanine Ammonia-Lyase
pubmed doi rcsb
molecule tags Lyase
source organism Petroselinum crispum
molecule keywords PHENYLALANINE AMMONIA-LYASE 1
total genus 254
structure length 689
sequence length 690
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2004-06-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1w27A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1w27A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1w27A02
2NYFA 2FUSA 3NZ4A 1K62A 1TJWA 2PTRA 3OCFA 2QGAB 3R6YA 1HY0A 1K7WA 1FURA 2O7EA 5D6BA 1C3UA 3RD8A 1FUQA 1FUOA 3KDYA 5EYVA 3CZOA 4HGVA 1Y2MA 2O7DA 1I0AA 1GK3A 2OHYA 1T6PA 4C6GA 1J3UA 1YFEA 2O7FA 1VDKA 2O78A 3GTDA 1KQ7A 4NSLA 3GZHA 2YIIA 3KDZA 4FLCA 2PTSA 5F91A 4C5RA 4V2QA 4CQ5A 1T6JA 1B8FA 4ADMA 3OCEA 2PFMA 1DCNA 1GKMA 4MX2A 4EEIA 1AUWA 4C5SA 2O6YA 3RRPA 2RJSA 2O7BA 4BABA 4C5UA 1YFMA 3QBPA 1XWOA 3E04A 5EYTA 2VD6A 3R6VA 3NO9A 1DOFA 4APBA 3C8TA 5HW2A 4APAA 1U16A 1HY1A 2RJRA 1GK2A 3BHGA 4EFCA 1YISA 1TJ7A 4ADLA 2X75A 1FUPA 1TJVA 4BAAA 1W27A 1RE5A 3TV2A 1GKJA 2E9FA 3R6QA 2QVEA 1JSWA 1EB4A 1U15A 5F92A 4NLEA 2J91A 4V2RA 3UNVA 2NYNA 2PTQA 1Q5NA 1TJUA 1C3CA 4FFXA 2HVGA
chains in the Genus database with same CATH superfamily
2NYFA 2FUSA 3NZ4A 3U44A 2EZAA 1K62A 3GTJA 1XMDA 2VSFA 1TJWA 4CEIA 2PTRA 1TWHA 3OCFA 2K3NA 2NVYA 2JA6A 2QGAB 1SMYD 3R6YA 1HY0A 1K7WA 2A6HD 4FBSA 2YU9A 1FURA 2O7EA 5D6BA 2FENA 1TWAA 2A69D 1C3UA 1FUQA 1FUOA 3KDYA 3RD8A 4A15A 1HQMD 2A68D 5EYVA 1I6VD 1Y1VA 1Y2MA 3GTOA 2O7DA 1I0AA 3CZOA 4HGVA 1GK3A 2VUMA 2EZCA 3U4QA 3GTLA 1EZAA 2OHYA 2R92A 1I50A 2CW0D 1T6PA 4C6GA 3GTPA 1J3UA 2HWGA 1YFEA 2O7FA 1VDKA 4WNLA 5H8WA 3FKIA 1R9TA 3GTQA 1IW7D 1YNND 3EZEA 1ZYRD 1KQ7A 2O78A 3GTDA 4NSLA 5M0IA 3LR2A 3GZHA 2K3QA 2YIIA 3GTKA 2N3EA 2JA7A 3KDZA 4FLCA 3EZBA 2PTSA 5F91A 4C5RA 2HROA 2B63A 4QIWA 4V2QA 4CQ5A 2MQAA 1T6JA 1XL8A 2MP0A 2K3OA 1B8FA 1WCMA 4ADMA 3OCEA 2PFMA 3GTGA 1DCNA 1GKMA 4MX2A 2E2HA 4EEIA 1AUWA 4C5SA 2E2IA 1EZBA 3LRDA 2FIOA 2JA5A 2O6YA 2LPJA 3RRPA 2O5JD 4CEHA 5M0JA 2AQLA 2O7BA 2RJSA 2X0OA 4BABA 4C5UA 1YFMA 1TWFA 1YNJD 3QBPA 1XWOA 3E04A 2X0PA 5EYTA 2R93A 2VD6A 3R6VA 3NO9A 1DOFA 4APBA 1ZYMA 3C8TA 5HW2A 3CRVA 4APAA 1U16A 1HY1A 2RJRA 1GK2A 3LR8A 2MX9A 3H0GA 3BHGA 3CRW1 1I3QA 4EFCA 1YISA 2LPIA 1TJ7A 4ADLA 2LYIA 1K83A 2X75A 2EZBA 1FUPA 2A6ED 1TJVA 2VK9A 4BAAA 1W27A 4C2MA 1Y1WA 1RE5A 3TV2A 1GKJA 2E9FA 3R6QA 1TWCA 2QVEA 1XLYA 2F5JA 1JSWA 1SFOA 1EB4A 1U15A 5F92A 3CQZA 4NLEA 2J91A 2FIPA 2N1DB 5IZ2A 2NVXA 2BE5D 1XL7A 2Y0NA 2R7ZA 2LTHA 2MX8A 4V2RA 1TWGA 1XMCA 2FELA 3UNVA 2VL7A 2NYNA 2LKMB 2PTQA 2X0QA 4CEJA 1Q5NA 1TJUA 3GTMA 3EZAA 3LR6A 1C3CA 4FFXA 2HVGA
chains in the Genus database with same CATH topology
2NYFA 2FUSA 3NZ4A 1K62A 1TJWA 2PTRA 3OCFA 2QGAB 3R6YA 1HY0A 1K7WA 1FURA 2O7EA 5D6BA 1C3UA 3RD8A 1FUQA 1FUOA 3KDYA 5EYVA 3CZOA 4HGVA 1Y2MA 2O7DA 1I0AA 1GK3A 2OHYA 1T6PA 4C6GA 1J3UA 1YFEA 2O7FA 1VDKA 2O78A 3GTDA 1KQ7A 4NSLA 3GZHA 2YIIA 3KDZA 4FLCA 2PTSA 5F91A 4C5RA 4V2QA 4CQ5A 1T6JA 1B8FA 4ADMA 3OCEA 2PFMA 1DCNA 1GKMA 4MX2A 4EEIA 1AUWA 4C5SA 2O6YA 3RRPA 2RJSA 2O7BA 4BABA 4C5UA 1YFMA 3QBPA 1XWOA 3E04A 5EYTA 2VD6A 3R6VA 3NO9A 1DOFA 4APBA 3C8TA 5HW2A 4APAA 1U16A 1HY1A 2RJRA 1GK2A 3BHGA 4EFCA 1YISA 1TJ7A 4ADLA 2X75A 1FUPA 1TJVA 4BAAA 1W27A 1RE5A 3TV2A 1GKJA 2E9FA 3R6QA 2QVEA 1JSWA 1EB4A 1U15A 5F92A 4NLEA 2J91A 4V2RA 3UNVA 2NYNA 2PTQA 1Q5NA 1TJUA 1C3CA 4FFXA 2HVGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NYF A;  2FUS A;  3NZ4 A;  1K62 A;  1TJW A;  2PTR A;  3OCF A;  2QGA B;  3R6Y A;  1HY0 A;  1K7W A;  1FUR A;  2O7E A;  5D6B A;  1C3U A;  3RD8 A;  1FUQ A;  1FUO A;  3KDY A;  5EYV A;  3CZO A;  4HGV A;  1Y2M A;  2O7D A;  1I0A A;  1GK3 A;  2OHY A;  1T6P A;  4C6G A;  1J3U A;  1YFE A;  2O7F A;  1VDK A;  2O78 A;  3GTD A;  1KQ7 A;  4NSL A;  3GZH A;  2YII A;  3KDZ A;  4FLC A;  2PTS A;  5F91 A;  4C5R A;  4V2Q A;  4CQ5 A;  1T6J A;  1B8F A;  4ADM A;  3OCE A;  2PFM A;  1DCN A;  1GKM A;  4MX2 A;  4EEI A;  1AUW A;  4C5S A;  2O6Y A;  3RRP A;  2RJS A;  2O7B A;  4BAB A;  4C5U A;  1YFM A;  3QBP A;  1XWO A;  3E04 A;  5EYT A;  2VD6 A;  3R6V A;  3NO9 A;  1DOF A;  4APB A;  3C8T A;  5HW2 A;  4APA A;  1U16 A;  1HY1 A;  2RJR A;  1GK2 A;  3BHG A;  4EFC A;  1YIS A;  1TJ7 A;  4ADL A;  2X75 A;  1FUP A;  1TJV A;  4BAA A;  1W27 A;  1RE5 A;  3TV2 A;  1GKJ A;  2E9F A;  3R6Q A;  2QVE A;  1JSW A;  1EB4 A;  1U15 A;  5F92 A;  4NLE A;  2J91 A;  4V2R A;  3UNV A;  2NYN A;  2PTQ A;  1Q5N A;  1TJU A;  1C3C A;  4FFX A;  2HVG A; 
#chains in the Genus database with same CATH topology
 2NYF A;  2FUS A;  3NZ4 A;  3U44 A;  2EZA A;  1K62 A;  3GTJ A;  1XMD A;  2VSF A;  1TJW A;  4CEI A;  2PTR A;  1TWH A;  3OCF A;  2K3N A;  2NVY A;  2JA6 A;  2QGA B;  1SMY D;  3R6Y A;  1HY0 A;  1K7W A;  2A6H D;  4FBS A;  2YU9 A;  1FUR A;  2O7E A;  5D6B A;  2FEN A;  1TWA A;  2A69 D;  1C3U A;  1FUQ A;  1FUO A;  3KDY A;  3RD8 A;  4A15 A;  1HQM D;  2A68 D;  5EYV A;  1I6V D;  1Y1V A;  1Y2M A;  3GTO A;  2O7D A;  1I0A A;  3CZO A;  4HGV A;  1GK3 A;  2VUM A;  2EZC A;  3U4Q A;  3GTL A;  1EZA A;  2OHY A;  2R92 A;  1I50 A;  2CW0 D;  1T6P A;  4C6G A;  3GTP A;  1J3U A;  2HWG A;  1YFE A;  2O7F A;  1VDK A;  4WNL A;  5H8W A;  3FKI A;  1R9T A;  3GTQ A;  1IW7 D;  1YNN D;  3EZE A;  1ZYR D;  1KQ7 A;  2O78 A;  3GTD A;  4NSL A;  5M0I A;  3LR2 A;  3GZH A;  2K3Q A;  2YII A;  3GTK A;  2N3E A;  2JA7 A;  3KDZ A;  4FLC A;  3EZB A;  2PTS A;  5F91 A;  4C5R A;  2HRO A;  2B63 A;  4QIW A;  4V2Q A;  4CQ5 A;  2MQA A;  1T6J A;  1XL8 A;  2MP0 A;  2K3O A;  1B8F A;  1WCM A;  4ADM A;  3OCE A;  2PFM A;  3GTG A;  1DCN A;  1GKM A;  4MX2 A;  2E2H A;  4EEI A;  1AUW A;  4C5S A;  2E2I A;  1EZB A;  3LRD A;  2FIO A;  2JA5 A;  2O6Y A;  2LPJ A;  3RRP A;  2O5J D;  4CEH A;  5M0J A;  2AQL A;  2O7B A;  2RJS A;  2X0O A;  4BAB A;  4C5U A;  1YFM A;  1TWF A;  1YNJ D;  3QBP A;  1XWO A;  3E04 A;  2X0P A;  5EYT A;  2R93 A;  2VD6 A;  3R6V A;  3NO9 A;  1DOF A;  4APB A;  1ZYM A;  3C8T A;  5HW2 A;  3CRV A;  4APA A;  1U16 A;  1HY1 A;  2RJR A;  1GK2 A;  3LR8 A;  2MX9 A;  3H0G A;  3BHG A;  3CRW 1;  1I3Q A;  4EFC A;  1YIS A;  2LPI A;  1TJ7 A;  4ADL A;  2LYI A;  1K83 A;  2X75 A;  2EZB A;  1FUP A;  2A6E D;  1TJV A;  2VK9 A;  4BAA A;  1W27 A;  4C2M A;  1Y1W A;  1RE5 A;  3TV2 A;  1GKJ A;  2E9F A;  3R6Q A;  1TWC A;  2QVE A;  1XLY A;  2F5J A;  1JSW A;  1SFO A;  1EB4 A;  1U15 A;  5F92 A;  3CQZ A;  4NLE A;  2J91 A;  2FIP A;  2N1D B;  5IZ2 A;  2NVX A;  2BE5 D;  1XL7 A;  2Y0N A;  2R7Z A;  2LTH A;  2MX8 A;  4V2R A;  1TWG A;  1XMC A;  2FEL A;  3UNV A;  2VL7 A;  2NYN A;  2LKM B;  2PTQ A;  2X0Q A;  4CEJ A;  1Q5N A;  1TJU A;  3GTM A;  3EZA A;  3LR6 A;  1C3C A;  4FFX A;  2HVG A; 
#chains in the Genus database with same CATH homology
 2NYF A;  2FUS A;  3NZ4 A;  1K62 A;  1TJW A;  2PTR A;  3OCF A;  2QGA B;  3R6Y A;  1HY0 A;  1K7W A;  1FUR A;  2O7E A;  5D6B A;  1C3U A;  3RD8 A;  1FUQ A;  1FUO A;  3KDY A;  5EYV A;  3CZO A;  4HGV A;  1Y2M A;  2O7D A;  1I0A A;  1GK3 A;  2OHY A;  1T6P A;  4C6G A;  1J3U A;  1YFE A;  2O7F A;  1VDK A;  2O78 A;  3GTD A;  1KQ7 A;  4NSL A;  3GZH A;  2YII A;  3KDZ A;  4FLC A;  2PTS A;  5F91 A;  4C5R A;  4V2Q A;  4CQ5 A;  1T6J A;  1B8F A;  4ADM A;  3OCE A;  2PFM A;  1DCN A;  1GKM A;  4MX2 A;  4EEI A;  1AUW A;  4C5S A;  2O6Y A;  3RRP A;  2RJS A;  2O7B A;  4BAB A;  4C5U A;  1YFM A;  3QBP A;  1XWO A;  3E04 A;  5EYT A;  2VD6 A;  3R6V A;  3NO9 A;  1DOF A;  4APB A;  3C8T A;  5HW2 A;  4APA A;  1U16 A;  1HY1 A;  2RJR A;  1GK2 A;  3BHG A;  4EFC A;  1YIS A;  1TJ7 A;  4ADL A;  2X75 A;  1FUP A;  1TJV A;  4BAA A;  1W27 A;  1RE5 A;  3TV2 A;  1GKJ A;  2E9F A;  3R6Q A;  2QVE A;  1JSW A;  1EB4 A;  1U15 A;  5F92 A;  4NLE A;  2J91 A;  4V2R A;  3UNV A;  2NYN A;  2PTQ A;  1Q5N A;  1TJU A;  1C3C A;  4FFX A;  2HVG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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