1W27A

Phenylalanine ammonia-lyase (pal) from petroselinum crispum
Total Genus 254
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
254
sequence length
690
structure length
689
Chain Sequence
EDPLYWGIAAEAMTGSHLDEVKKMVAEYRKPVVKLGGETLTISQVAAISARDGSGVTVELSEAARAGVKASSDWVMDSMNKGTDSYGVTTGFGATSHRRTKQGGALQKELIRFLNAGIFGNGSDNTLPHSATRAAMLVRINTLLQGYSGIRFEILEAITKFLNQNITPCLPLRGTITDLVPLSYIAGLLTGRPNSKAVGPTGVILSPEEAFKLAGVEGGFFELQPKEGLALVNGTAVGSGMASMVLFEANILAVLAEVMSAIFAEVMQGKPEFTDHLTHKLKHHPGQIEAAAIMEHILDGSAYVKAAQKLHEMDPLQKPKQDRYALRTSPQWLGPQIEVIRSSTKMIEREINSVNDNPLIDVSRNKAIHGGNFQGTPIGVSMDNTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNLSGGRNPSLDYGFKGAEIAMASYCSELQFLANPVTNHVQSAEQHNQDVNSLGLISSRKTSEAVEILKLMSTTFLVGLCQAIDLRHLEENLKSTVKNTVSSVAKRVLTMGVNGELHPSRFCEKDLLRVVDREYIFAYIDDPCSATYPLMQKLRQTLVEHALKNGDNERNLSTSIFQKIATFEDELKALLPKEVESARAALESGNPAIPNRIEECRSYPLYKFVRKELGTEYLTGEKVTSPGEEFEKVFIAMSKGEIIDPLLECLESWNGAPLPIC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for the Entrance Into the Phenylpropanoid Metabolism Catalyzed by Phenylalanine Ammonia-Lyase
pubmed doi rcsb
molecule tags Lyase
source organism Petroselinum crispum
molecule keywords PHENYLALANINE AMMONIA-LYASE 1
total genus 254
structure length 689
sequence length 690
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2004-06-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 1w27A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 1w27A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 1w27A02
1TJWA 5F91A 3E04A 1AUWA 1U16A 5D6BA 1GK3A 1YISA 3KDZA 3UNVA 1HY1A 4APBA 2PTSA 1TJUA 3GZHA 1GK2A 1C3UA 4CQ5A 1GKJA 4C6GA 1DOFA 3CZOA 1FURA 2X75A 2O78A 4EEIA 1VDKA 4EFCA 2VD6A 2PTRA 3R6VA 1T6PA 4APAA 5EYTA 3QBPA 1HY0A 4V2QA 2O7EA 2YIIA 1K62A 5F92A 4MX2A 4FLCA 1RE5A 2PFMA 1FUQA 2O7BA 1J3UA 4BABA 3KDYA 1DCNA 4FFXA 3C8TA 2HVGA 2O6YA 4NSLA 2QGAB 1FUOA 1I0AA 3R6YA 2FUSA 2NYFA 1JSWA 4C5SA 3NZ4A 4HGVA 1T6JA 2PTQA 2QVEA 2O7FA 3TV2A 4ADMA 4BAAA 2OHYA 1YFEA 1Y2MA 1YFMA 4ADLA 3RRPA 1Q5NA 1XWOA 3OCFA 1C3CA 2E9FA 3BHGA 2O7DA 4C5UA 1FUPA 4NLEA 2NYNA 1TJVA 4V2RA 5EYVA 3OCEA 3RD8A 1KQ7A 3R6QA 2RJRA 4C5RA 1U15A 1B8FA 1TJ7A 5HW2A 1EB4A 2J91A 3GTDA 3NO9A 1GKMA 2RJSA 1K7WA 1W27A
chains in the Genus database with same CATH superfamily
1XL7A 1TJWA 5F91A 3E04A 2Y0NA 1AUWA 1U16A 2E2HA 1XMCA 2VSFA 5D6BA 1GK3A 1YNND 1YISA 2A68D 3KDZA 3UNVA 2HROA 1HY1A 1I3QA 2PTSA 1TJUA 4APBA 3GZHA 1SFOA 2EZBA 1GK2A 3LR2A 3GTJA 1C3UA 2A6ED 2K3NA 4CQ5A 2FIOA 1GKJA 4C6GA 3CRVA 2EZAA 1DOFA 3CZOA 1FURA 2A69D 2X75A 1IW7D 2O78A 4EEIA 1VDKA 4EFCA 2VL7A 1WCMA 1EZAA 2VD6A 2PTRA 2N3EA 1YNJD 1T6PA 2E2IA 3R6VA 2VK9A 4APAA 5M0IA 5EYTA 2JA5A 4CEJA 3LR6A 1HY0A 3QBPA 1Y1VA 4V2QA 2BE5D 2MP0A 2O7EA 2YIIA 1TWCA 1EZBA 1K62A 5F92A 4MX2A 4FLCA 1R9TA 2VUMA 1RE5A 3GTGA 2X0QA 4C2MA 2PFMA 1K83A 1FUQA 2O7BA 1J3UA 4BABA 1I50A 3KDYA 2JA7A 1DCNA 4FFXA 3H0GA 2HWGA 2F5JA 3C8TA 2HVGA 2O6YA 1TWHA 4NSLA 3U44A 2QGAB 2CW0D 2LKMB 3GTKA 2R7ZA 2LTHA 1FUOA 1Y1WA 3EZBA 1I0AA 1XLYA 3R6YA 2FUSA 3GTLA 2NYFA 2K3OA 2FIPA 1JSWA 2MX8A 4WNLA 4C5SA 3NZ4A 2JA6A 4HGVA 3CRW1 5IZ2A 1T6JA 4FBSA 2R93A 2PTQA 2QVEA 2O7FA 2FENA 3TV2A 2EZCA 2MX9A 4ADMA 1ZYMA 4BAAA 2OHYA 2N1DB 2X0PA 1YFEA 1Y2MA 1YFMA 1TWAA 4ADLA 3RRPA 1Q5NA 1XWOA 3OCFA 2NVYA 1C3CA 1XL8A 1TWFA 3LRDA 4CEIA 2E9FA 3BHGA 3EZAA 2O7DA 4C5UA 5M0JA 2LYIA 2MQAA 1FUPA 4NLEA 4A15A 2NYNA 1TJVA 4V2RA 2YU9A 5EYVA 3GTOA 3OCEA 3RD8A 3CQZA 2R92A 1KQ7A 3FKIA 3LR8A 3R6QA 1I6VD 3EZEA 4QIWA 2RJRA 1HQMD 4C5RA 1U15A 2NVXA 1B8FA 2FELA 3U4QA 1XMDA 2LPIA 2LPJA 1SMYD 2AQLA 3GTMA 2O5JD 1TJ7A 5HW2A 1TWGA 2A6HD 1EB4A 2J91A 2K3QA 4CEHA 3GTPA 5H8WA 3GTQA 3GTDA 3NO9A 2X0OA 2B63A 1GKMA 2RJSA 1ZYRD 1K7WA 1W27A
chains in the Genus database with same CATH topology
1TJWA 5F91A 3E04A 1AUWA 1U16A 5D6BA 1GK3A 1YISA 3KDZA 3UNVA 1HY1A 4APBA 2PTSA 1TJUA 3GZHA 1GK2A 1C3UA 4CQ5A 1GKJA 4C6GA 1DOFA 3CZOA 1FURA 2X75A 2O78A 4EEIA 1VDKA 4EFCA 2VD6A 2PTRA 3R6VA 1T6PA 4APAA 5EYTA 3QBPA 1HY0A 4V2QA 2O7EA 2YIIA 1K62A 5F92A 4MX2A 4FLCA 1RE5A 2PFMA 1FUQA 2O7BA 1J3UA 4BABA 3KDYA 1DCNA 4FFXA 3C8TA 2HVGA 2O6YA 4NSLA 2QGAB 1FUOA 1I0AA 3R6YA 2FUSA 2NYFA 1JSWA 4C5SA 3NZ4A 4HGVA 1T6JA 2PTQA 2QVEA 2O7FA 3TV2A 4ADMA 4BAAA 2OHYA 1YFEA 1Y2MA 1YFMA 4ADLA 3RRPA 1Q5NA 1XWOA 3OCFA 1C3CA 2E9FA 3BHGA 2O7DA 4C5UA 1FUPA 4NLEA 2NYNA 1TJVA 4V2RA 5EYVA 3OCEA 3RD8A 1KQ7A 3R6QA 2RJRA 4C5RA 1U15A 1B8FA 1TJ7A 5HW2A 1EB4A 2J91A 3GTDA 3NO9A 1GKMA 2RJSA 1K7WA 1W27A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TJW A;  5F91 A;  3E04 A;  1AUW A;  1U16 A;  5D6B A;  1GK3 A;  1YIS A;  3KDZ A;  3UNV A;  1HY1 A;  4APB A;  2PTS A;  1TJU A;  3GZH A;  1GK2 A;  1C3U A;  4CQ5 A;  1GKJ A;  4C6G A;  1DOF A;  3CZO A;  1FUR A;  2X75 A;  2O78 A;  4EEI A;  1VDK A;  4EFC A;  2VD6 A;  2PTR A;  3R6V A;  1T6P A;  4APA A;  5EYT A;  3QBP A;  1HY0 A;  4V2Q A;  2O7E A;  2YII A;  1K62 A;  5F92 A;  4MX2 A;  4FLC A;  1RE5 A;  2PFM A;  1FUQ A;  2O7B A;  1J3U A;  4BAB A;  3KDY A;  1DCN A;  4FFX A;  3C8T A;  2HVG A;  2O6Y A;  4NSL A;  2QGA B;  1FUO A;  1I0A A;  3R6Y A;  2FUS A;  2NYF A;  1JSW A;  4C5S A;  3NZ4 A;  4HGV A;  1T6J A;  2PTQ A;  2QVE A;  2O7F A;  3TV2 A;  4ADM A;  4BAA A;  2OHY A;  1YFE A;  1Y2M A;  1YFM A;  4ADL A;  3RRP A;  1Q5N A;  1XWO A;  3OCF A;  1C3C A;  2E9F A;  3BHG A;  2O7D A;  4C5U A;  1FUP A;  4NLE A;  2NYN A;  1TJV A;  4V2R A;  5EYV A;  3OCE A;  3RD8 A;  1KQ7 A;  3R6Q A;  2RJR A;  4C5R A;  1U15 A;  1B8F A;  1TJ7 A;  5HW2 A;  1EB4 A;  2J91 A;  3GTD A;  3NO9 A;  1GKM A;  2RJS A;  1K7W A;  1W27 A; 
#chains in the Genus database with same CATH topology
 1XL7 A;  1TJW A;  5F91 A;  3E04 A;  2Y0N A;  1AUW A;  1U16 A;  2E2H A;  1XMC A;  2VSF A;  5D6B A;  1GK3 A;  1YNN D;  1YIS A;  2A68 D;  3KDZ A;  3UNV A;  2HRO A;  1HY1 A;  1I3Q A;  2PTS A;  1TJU A;  4APB A;  3GZH A;  1SFO A;  2EZB A;  1GK2 A;  3LR2 A;  3GTJ A;  1C3U A;  2A6E D;  2K3N A;  4CQ5 A;  2FIO A;  1GKJ A;  4C6G A;  3CRV A;  2EZA A;  1DOF A;  3CZO A;  1FUR A;  2A69 D;  2X75 A;  1IW7 D;  2O78 A;  4EEI A;  1VDK A;  4EFC A;  2VL7 A;  1WCM A;  1EZA A;  2VD6 A;  2PTR A;  2N3E A;  1YNJ D;  1T6P A;  2E2I A;  3R6V A;  2VK9 A;  4APA A;  5M0I A;  5EYT A;  2JA5 A;  4CEJ A;  3LR6 A;  1HY0 A;  3QBP A;  1Y1V A;  4V2Q A;  2BE5 D;  2MP0 A;  2O7E A;  2YII A;  1TWC A;  1EZB A;  1K62 A;  5F92 A;  4MX2 A;  4FLC A;  1R9T A;  2VUM A;  1RE5 A;  3GTG A;  2X0Q A;  4C2M A;  2PFM A;  1K83 A;  1FUQ A;  2O7B A;  1J3U A;  4BAB A;  1I50 A;  3KDY A;  2JA7 A;  1DCN A;  4FFX A;  3H0G A;  2HWG A;  2F5J A;  3C8T A;  2HVG A;  2O6Y A;  1TWH A;  4NSL A;  3U44 A;  2QGA B;  2CW0 D;  2LKM B;  3GTK A;  2R7Z A;  2LTH A;  1FUO A;  1Y1W A;  3EZB A;  1I0A A;  1XLY A;  3R6Y A;  2FUS A;  3GTL A;  2NYF A;  2K3O A;  2FIP A;  1JSW A;  2MX8 A;  4WNL A;  4C5S A;  3NZ4 A;  2JA6 A;  4HGV A;  3CRW 1;  5IZ2 A;  1T6J A;  4FBS A;  2R93 A;  2PTQ A;  2QVE A;  2O7F A;  2FEN A;  3TV2 A;  2EZC A;  2MX9 A;  4ADM A;  1ZYM A;  4BAA A;  2OHY A;  2N1D B;  2X0P A;  1YFE A;  1Y2M A;  1YFM A;  1TWA A;  4ADL A;  3RRP A;  1Q5N A;  1XWO A;  3OCF A;  2NVY A;  1C3C A;  1XL8 A;  1TWF A;  3LRD A;  4CEI A;  2E9F A;  3BHG A;  3EZA A;  2O7D A;  4C5U A;  5M0J A;  2LYI A;  2MQA A;  1FUP A;  4NLE A;  4A15 A;  2NYN A;  1TJV A;  4V2R A;  2YU9 A;  5EYV A;  3GTO A;  3OCE A;  3RD8 A;  3CQZ A;  2R92 A;  1KQ7 A;  3FKI A;  3LR8 A;  3R6Q A;  1I6V D;  3EZE A;  4QIW A;  2RJR A;  1HQM D;  4C5R A;  1U15 A;  2NVX A;  1B8F A;  2FEL A;  3U4Q A;  1XMD A;  2LPI A;  2LPJ A;  1SMY D;  2AQL A;  3GTM A;  2O5J D;  1TJ7 A;  5HW2 A;  1TWG A;  2A6H D;  1EB4 A;  2J91 A;  2K3Q A;  4CEH A;  3GTP A;  5H8W A;  3GTQ A;  3GTD A;  3NO9 A;  2X0O A;  2B63 A;  1GKM A;  2RJS A;  1ZYR D;  1K7W A;  1W27 A; 
#chains in the Genus database with same CATH homology
 1TJW A;  5F91 A;  3E04 A;  1AUW A;  1U16 A;  5D6B A;  1GK3 A;  1YIS A;  3KDZ A;  3UNV A;  1HY1 A;  4APB A;  2PTS A;  1TJU A;  3GZH A;  1GK2 A;  1C3U A;  4CQ5 A;  1GKJ A;  4C6G A;  1DOF A;  3CZO A;  1FUR A;  2X75 A;  2O78 A;  4EEI A;  1VDK A;  4EFC A;  2VD6 A;  2PTR A;  3R6V A;  1T6P A;  4APA A;  5EYT A;  3QBP A;  1HY0 A;  4V2Q A;  2O7E A;  2YII A;  1K62 A;  5F92 A;  4MX2 A;  4FLC A;  1RE5 A;  2PFM A;  1FUQ A;  2O7B A;  1J3U A;  4BAB A;  3KDY A;  1DCN A;  4FFX A;  3C8T A;  2HVG A;  2O6Y A;  4NSL A;  2QGA B;  1FUO A;  1I0A A;  3R6Y A;  2FUS A;  2NYF A;  1JSW A;  4C5S A;  3NZ4 A;  4HGV A;  1T6J A;  2PTQ A;  2QVE A;  2O7F A;  3TV2 A;  4ADM A;  4BAA A;  2OHY A;  1YFE A;  1Y2M A;  1YFM A;  4ADL A;  3RRP A;  1Q5N A;  1XWO A;  3OCF A;  1C3C A;  2E9F A;  3BHG A;  2O7D A;  4C5U A;  1FUP A;  4NLE A;  2NYN A;  1TJV A;  4V2R A;  5EYV A;  3OCE A;  3RD8 A;  1KQ7 A;  3R6Q A;  2RJR A;  4C5R A;  1U15 A;  1B8F A;  1TJ7 A;  5HW2 A;  1EB4 A;  2J91 A;  3GTD A;  3NO9 A;  1GKM A;  2RJS A;  1K7W A;  1W27 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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