3NZ4A

Crystal structure of a taxus phenylalanine aminomutase
Total Genus 257
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
257
sequence length
670
structure length
653
Chain Sequence
SRSHVKDILGLINTFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNQLSELQESLIRCLLAGVFTKGCASSVDELPATVTRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATALASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQDLSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTDEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFGSILALHKETDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSRFLPFYRFVRDELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFLG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Mechanistic, mutational, and structural evaluation of a taxus phenylalanine aminomutase.
pubmed doi rcsb
molecule tags Lyase
source organism Taxus canadensis
molecule keywords Phenylalanine ammonia-lyase
total genus 257
structure length 653
sequence length 670
chains with identical sequence B
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2010-07-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 3nz4A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 3nz4A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 3nz4A02
4C5RA 1YFMA 4C6GA 2VD6A 3RRPA 4HGVA 5F92A 2J91A 2PTRA 4NLEA 2FUSA 1FUQA 1GKMA 1TJWA 4NSLA 3CZOA 3C8TA 1I0AA 3E04A 1DOFA 3TV2A 4APAA 4EEIA 3OCFA 2NYFA 2PFMA 1VDKA 1W27A 1DCNA 5EYVA 3NO9A 1T6JA 2YIIA 1XWOA 2RJSA 4BAAA 5D6BA 3UNVA 1C3CA 2QVEA 4CQ5A 1YISA 4C5SA 2O7BA 3R6VA 4APBA 3BHGA 1Q5NA 2O7FA 2RJRA 1TJVA 1J3UA 1GK2A 2O6YA 2O78A 3OCEA 1YFEA 2PTSA 4C5UA 3KDZA 2O7EA 3NZ4A 4FFXA 2PTQA 1GKJA 5F91A 1FUPA 2NYNA 4V2QA 3GZHA 1B8FA 3RD8A 2QGAB 4EFCA 1T6PA 1U16A 1AUWA 1EB4A 1K7WA 1RE5A 4V2RA 1GK3A 5EYTA 2HVGA 1TJ7A 1FUOA 2X75A 5HW2A 4MX2A 1K62A 1Y2MA 3QBPA 2OHYA 3GTDA 4ADLA 1KQ7A 1HY0A 1C3UA 3KDYA 3R6QA 2O7DA 3R6YA 4ADMA 1TJUA 2E9FA 1HY1A 1JSWA 4FLCA 4BABA 1U15A 1FURA
chains in the Genus database with same CATH superfamily
2MP0A 4C5RA 1YFMA 4C6GA 1TWGA 2VD6A 3RRPA 2MQAA 3LR6A 4HGVA 3H0GA 3GTLA 5F92A 2J91A 2O5JD 3EZBA 1TWFA 2FELA 1XMCA 2PTRA 2HROA 5M0IA 1Y1WA 4NLEA 2FUSA 1FUQA 1XL7A 3CQZA 1I6VD 1GKMA 1TJWA 2VUMA 1XMDA 4NSLA 1I50A 3EZEA 3CZOA 3C8TA 1I0AA 3E04A 1DOFA 1SFOA 3TV2A 4APAA 5IZ2A 1TWAA 4EEIA 2R7ZA 3GTPA 2B63A 3GTQA 2FIOA 2NYFA 2E2HA 3OCFA 2K3OA 2PFMA 3CRW1 1VDKA 2N3EA 3LR8A 1W27A 2K3NA 1TWHA 1I3QA 4CEJA 2NVYA 1DCNA 2R93A 2A69D 2A6ED 2X0PA 3GTKA 2N1DB 5EYVA 2VSFA 3NO9A 1T6JA 4CEHA 2YIIA 1XWOA 2RJSA 2NVXA 4A15A 4BAAA 5D6BA 3UNVA 2JA5A 2LYIA 4FBSA 2LTHA 1C3CA 4CQ5A 1YISA 2QVEA 2Y0NA 4C5SA 2O7BA 2A6HD 2JA7A 3R6VA 4APBA 3BHGA 2MX9A 1YNJD 2VL7A 2X0QA 1WCMA 1Q5NA 2O7FA 2RJRA 1TJVA 1J3UA 2EZBA 2LPIA 2A68D 1HQMD 1GK2A 2O6YA 1IW7D 2O78A 4WNLA 3OCEA 1XLYA 2R92A 1YFEA 4C5UA 2PTSA 3KDZA 1K83A 2O7EA 1R9TA 4CEIA 2E2IA 1ZYMA 3NZ4A 4FFXA 2PTQA 2AQLA 1Y1VA 2F5JA 1GKJA 5F91A 1FUPA 2NYNA 4V2QA 2JA6A 3GZHA 1B8FA 3GTGA 3CRVA 3RD8A 2QGAB 4EFCA 1T6PA 3U44A 1U16A 2X0OA 3GTJA 1AUWA 2EZCA 2VK9A 1EB4A 1K7WA 2CW0D 2LKMB 3EZAA 1RE5A 5H8WA 4V2RA 1EZBA 1GK3A 2LPJA 5EYTA 2HVGA 5M0JA 1TJ7A 1FUOA 2X75A 5HW2A 1EZAA 1TWCA 2K3QA 4MX2A 1K62A 1XL8A 1Y2MA 2EZAA 1ZYRD 3QBPA 2HWGA 4C2MA 2OHYA 3GTDA 4ADLA 1KQ7A 1HY0A 3LR2A 3LRDA 1C3UA 3KDYA 2O7DA 3R6QA 2FIPA 3R6YA 1YNND 3FKIA 4ADMA 3GTMA 1TJUA 3U4QA 2E9FA 3GTOA 1HY1A 1JSWA 1SMYD 2FENA 2YU9A 2BE5D 2MX8A 4BABA 4FLCA 4QIWA 1U15A 1FURA
chains in the Genus database with same CATH topology
4C5RA 1YFMA 4C6GA 2VD6A 3RRPA 4HGVA 5F92A 2J91A 2PTRA 4NLEA 2FUSA 1FUQA 1GKMA 1TJWA 4NSLA 3CZOA 3C8TA 1I0AA 3E04A 1DOFA 3TV2A 4APAA 4EEIA 3OCFA 2NYFA 2PFMA 1VDKA 1W27A 1DCNA 5EYVA 3NO9A 1T6JA 2YIIA 1XWOA 2RJSA 4BAAA 5D6BA 3UNVA 1C3CA 2QVEA 4CQ5A 1YISA 4C5SA 2O7BA 3R6VA 4APBA 3BHGA 1Q5NA 2O7FA 2RJRA 1TJVA 1J3UA 1GK2A 2O6YA 2O78A 3OCEA 1YFEA 2PTSA 4C5UA 3KDZA 2O7EA 3NZ4A 4FFXA 2PTQA 1GKJA 5F91A 1FUPA 2NYNA 4V2QA 3GZHA 1B8FA 3RD8A 2QGAB 4EFCA 1T6PA 1U16A 1AUWA 1EB4A 1K7WA 1RE5A 4V2RA 1GK3A 5EYTA 2HVGA 1TJ7A 1FUOA 2X75A 5HW2A 4MX2A 1K62A 1Y2MA 3QBPA 2OHYA 3GTDA 4ADLA 1KQ7A 1HY0A 1C3UA 3KDYA 3R6QA 2O7DA 3R6YA 4ADMA 1TJUA 2E9FA 1HY1A 1JSWA 4FLCA 4BABA 1U15A 1FURA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4C5R A;  1YFM A;  4C6G A;  2VD6 A;  3RRP A;  4HGV A;  5F92 A;  2J91 A;  2PTR A;  4NLE A;  2FUS A;  1FUQ A;  1GKM A;  1TJW A;  4NSL A;  3CZO A;  3C8T A;  1I0A A;  3E04 A;  1DOF A;  3TV2 A;  4APA A;  4EEI A;  3OCF A;  2NYF A;  2PFM A;  1VDK A;  1W27 A;  1DCN A;  5EYV A;  3NO9 A;  1T6J A;  2YII A;  1XWO A;  2RJS A;  4BAA A;  5D6B A;  3UNV A;  1C3C A;  2QVE A;  4CQ5 A;  1YIS A;  4C5S A;  2O7B A;  3R6V A;  4APB A;  3BHG A;  1Q5N A;  2O7F A;  2RJR A;  1TJV A;  1J3U A;  1GK2 A;  2O6Y A;  2O78 A;  3OCE A;  1YFE A;  2PTS A;  4C5U A;  3KDZ A;  2O7E A;  3NZ4 A;  4FFX A;  2PTQ A;  1GKJ A;  5F91 A;  1FUP A;  2NYN A;  4V2Q A;  3GZH A;  1B8F A;  3RD8 A;  2QGA B;  4EFC A;  1T6P A;  1U16 A;  1AUW A;  1EB4 A;  1K7W A;  1RE5 A;  4V2R A;  1GK3 A;  5EYT A;  2HVG A;  1TJ7 A;  1FUO A;  2X75 A;  5HW2 A;  4MX2 A;  1K62 A;  1Y2M A;  3QBP A;  2OHY A;  3GTD A;  4ADL A;  1KQ7 A;  1HY0 A;  1C3U A;  3KDY A;  3R6Q A;  2O7D A;  3R6Y A;  4ADM A;  1TJU A;  2E9F A;  1HY1 A;  1JSW A;  4FLC A;  4BAB A;  1U15 A;  1FUR A; 
#chains in the Genus database with same CATH topology
 2MP0 A;  4C5R A;  1YFM A;  4C6G A;  1TWG A;  2VD6 A;  3RRP A;  2MQA A;  3LR6 A;  4HGV A;  3H0G A;  3GTL A;  5F92 A;  2J91 A;  2O5J D;  3EZB A;  1TWF A;  2FEL A;  1XMC A;  2PTR A;  2HRO A;  5M0I A;  1Y1W A;  4NLE A;  2FUS A;  1FUQ A;  1XL7 A;  3CQZ A;  1I6V D;  1GKM A;  1TJW A;  2VUM A;  1XMD A;  4NSL A;  1I50 A;  3EZE A;  3CZO A;  3C8T A;  1I0A A;  3E04 A;  1DOF A;  1SFO A;  3TV2 A;  4APA A;  5IZ2 A;  1TWA A;  4EEI A;  2R7Z A;  3GTP A;  2B63 A;  3GTQ A;  2FIO A;  2NYF A;  2E2H A;  3OCF A;  2K3O A;  2PFM A;  3CRW 1;  1VDK A;  2N3E A;  3LR8 A;  1W27 A;  2K3N A;  1TWH A;  1I3Q A;  4CEJ A;  2NVY A;  1DCN A;  2R93 A;  2A69 D;  2A6E D;  2X0P A;  3GTK A;  2N1D B;  5EYV A;  2VSF A;  3NO9 A;  1T6J A;  4CEH A;  2YII A;  1XWO A;  2RJS A;  2NVX A;  4A15 A;  4BAA A;  5D6B A;  3UNV A;  2JA5 A;  2LYI A;  4FBS A;  2LTH A;  1C3C A;  4CQ5 A;  1YIS A;  2QVE A;  2Y0N A;  4C5S A;  2O7B A;  2A6H D;  2JA7 A;  3R6V A;  4APB A;  3BHG A;  2MX9 A;  1YNJ D;  2VL7 A;  2X0Q A;  1WCM A;  1Q5N A;  2O7F A;  2RJR A;  1TJV A;  1J3U A;  2EZB A;  2LPI A;  2A68 D;  1HQM D;  1GK2 A;  2O6Y A;  1IW7 D;  2O78 A;  4WNL A;  3OCE A;  1XLY A;  2R92 A;  1YFE A;  4C5U A;  2PTS A;  3KDZ A;  1K83 A;  2O7E A;  1R9T A;  4CEI A;  2E2I A;  1ZYM A;  3NZ4 A;  4FFX A;  2PTQ A;  2AQL A;  1Y1V A;  2F5J A;  1GKJ A;  5F91 A;  1FUP A;  2NYN A;  4V2Q A;  2JA6 A;  3GZH A;  1B8F A;  3GTG A;  3CRV A;  3RD8 A;  2QGA B;  4EFC A;  1T6P A;  3U44 A;  1U16 A;  2X0O A;  3GTJ A;  1AUW A;  2EZC A;  2VK9 A;  1EB4 A;  1K7W A;  2CW0 D;  2LKM B;  3EZA A;  1RE5 A;  5H8W A;  4V2R A;  1EZB A;  1GK3 A;  2LPJ A;  5EYT A;  2HVG A;  5M0J A;  1TJ7 A;  1FUO A;  2X75 A;  5HW2 A;  1EZA A;  1TWC A;  2K3Q A;  4MX2 A;  1K62 A;  1XL8 A;  1Y2M A;  2EZA A;  1ZYR D;  3QBP A;  2HWG A;  4C2M A;  2OHY A;  3GTD A;  4ADL A;  1KQ7 A;  1HY0 A;  3LR2 A;  3LRD A;  1C3U A;  3KDY A;  2O7D A;  3R6Q A;  2FIP A;  3R6Y A;  1YNN D;  3FKI A;  4ADM A;  3GTM A;  1TJU A;  3U4Q A;  2E9F A;  3GTO A;  1HY1 A;  1JSW A;  1SMY D;  2FEN A;  2YU9 A;  2BE5 D;  2MX8 A;  4BAB A;  4FLC A;  4QIW A;  1U15 A;  1FUR A; 
#chains in the Genus database with same CATH homology
 4C5R A;  1YFM A;  4C6G A;  2VD6 A;  3RRP A;  4HGV A;  5F92 A;  2J91 A;  2PTR A;  4NLE A;  2FUS A;  1FUQ A;  1GKM A;  1TJW A;  4NSL A;  3CZO A;  3C8T A;  1I0A A;  3E04 A;  1DOF A;  3TV2 A;  4APA A;  4EEI A;  3OCF A;  2NYF A;  2PFM A;  1VDK A;  1W27 A;  1DCN A;  5EYV A;  3NO9 A;  1T6J A;  2YII A;  1XWO A;  2RJS A;  4BAA A;  5D6B A;  3UNV A;  1C3C A;  2QVE A;  4CQ5 A;  1YIS A;  4C5S A;  2O7B A;  3R6V A;  4APB A;  3BHG A;  1Q5N A;  2O7F A;  2RJR A;  1TJV A;  1J3U A;  1GK2 A;  2O6Y A;  2O78 A;  3OCE A;  1YFE A;  2PTS A;  4C5U A;  3KDZ A;  2O7E A;  3NZ4 A;  4FFX A;  2PTQ A;  1GKJ A;  5F91 A;  1FUP A;  2NYN A;  4V2Q A;  3GZH A;  1B8F A;  3RD8 A;  2QGA B;  4EFC A;  1T6P A;  1U16 A;  1AUW A;  1EB4 A;  1K7W A;  1RE5 A;  4V2R A;  1GK3 A;  5EYT A;  2HVG A;  1TJ7 A;  1FUO A;  2X75 A;  5HW2 A;  4MX2 A;  1K62 A;  1Y2M A;  3QBP A;  2OHY A;  3GTD A;  4ADL A;  1KQ7 A;  1HY0 A;  1C3U A;  3KDY A;  3R6Q A;  2O7D A;  3R6Y A;  4ADM A;  1TJU A;  2E9F A;  1HY1 A;  1JSW A;  4FLC A;  4BAB A;  1U15 A;  1FUR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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