4C5R | Genus

Total Genus 264

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	264
sequence length	667
structure length	634
Chain Sequence	SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEACRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

molecule tags	Lyase
source organism	Taxus wallichiana var. chinensis
publication title	Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis. pubmed doi rcsb
molecule keywords	PHENYLALANINE AMMONIA-LYASE
total genus	264
structure length	634
sequence length	667
chains with identical sequence	B, C, D
ec nomenclature	ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date	2013-09-16

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00221	Lyase_aromatic	Aromatic amino acid lyase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.274.20	Mainly Alpha	Orthogonal Bundle	Enzyme I; Chain A, domain 2	Phenylalanine ammonia-lyase 1; domain 3	4c5rA03
1.10.275.10	Mainly Alpha	Orthogonal Bundle	Fumarase C; Chain B, domain 1	Fumarase/aspartase (N-terminal domain)	4c5rA01
1.20.200.10	Mainly Alpha	Up-down Bundle	Fumarase C; Chain A, domain 2	Fumarase/aspartase (Central domain)	4c5rA02

1GK2A 5F91A 2O78A 4V2QA 1XWOA 1TJVA 3GTDA 4NSLA 2PTQA 1HY0A 2NYNA 3RD8A 3OCFA 3GZHA 3KDZA 3NO9A 2E9FA 1DOFA 1TJWA 4BAAA 4MX2A 4HGVA 4C5RA 4APAA 3BHGA 1JSWA 1HY1A 1RE5A 1YISA 5D6BA 1TJ7A 1I0AA 2NYFA 1K62A 5F92A 5EYVA 1EB4A 1KQ7A 1FURA 2RJRA 1T6PA 2O7DA 3OCEA 1Q5NA 3C8TA 1U16A 1B8FA 2J91A 3E04A 4CQ5A 1U15A 2VD6A 1YFMA 3KDYA 4APBA 2QGAB 4EEIA 2O7EA 3RRPA 4C6GA 4C5SA 2PFMA 5HW2A 3R6QA 2PTSA 5EYTA 1VDKA 4BABA 1FUQA 1K7WA 1FUPA 1AUWA 2RJSA 2O7BA 1C3CA 2X75A 3UNVA 1GKMA 3R6YA 3TV2A 1FUOA 2YIIA 1GK3A 2FUSA 4NLEA 4C5UA 2QVEA 1J3UA 2OHYA 3CZOA 3QBPA 3R6VA 4ADMA 3NZ4A 1C3UA 2PTRA 4FLCA 1DCNA 4FFXA 4EFCA 2HVGA 1GKJA 4ADLA 4V2RA 1YFEA 1W27A 2O6YA 1TJUA 1Y2MA 2O7FA 1T6JA
chains in the Genus database with same CATH superfamily

1GK2A 5F91A 2O78A 4WNLA 2B63A 2JA7A 4V2QA 1XWOA 2EZAA 1XL7A 2JA5A 1TJVA 3GTDA 4NSLA 2PTQA 3LRDA 2MP0A 1HY0A 2NYNA 3RD8A 2LPJA 3OCFA 3GZHA 1XL8A 3KDZA 2F5JA 2E9FA 3NO9A 1DOFA 1TJWA 1WCMA 4BAAA 4MX2A 3EZAA 4HGVA 3GTQA 4C5RA 4APAA 3BHGA 1JSWA 3U4QA 1SFOA 1HY1A 1RE5A 1YISA 2LPIA 5D6BA 2K3NA 1TJ7A 1I0AA 2E2HA 2NYFA 1K62A 1EZBA 2HWGA 4CEJA 2FIPA 5F92A 4CEIA 5EYVA 4CEHA 1EB4A 1KQ7A 1FURA 2CW0D 3H0GA 2RJRA 2N3EA 1T6PA 1ZYRD 2VSFA 2A6ED 1YNND 2O7DA 2EZCA 3LR8A 3GTKA 1Q5NA 1XMCA 3OCEA 2A6HD 1XLYA 1I6VD 3C8TA 1U16A 1B8FA 1EZAA 2VK9A 4C2MA 2LYIA 2NVYA 2J91A 3E04A 2E2IA 2FELA 2VL7A 4CQ5A 1U15A 3CRVA 3LR2A 2VD6A 2K3OA 3U44A 1YFMA 2LTHA 2LKMB 3KDYA 1TWCA 4APBA 2A68D 2QGAB 2R93A 4EEIA 2O7EA 2R7ZA 1ZYMA 4C6GA 3RRPA 2MX9A 3FKIA 4C5SA 2PFMA 1R9TA 3R6QA 5HW2A 5M0JA 2PTSA 5EYTA 2AQLA 1VDKA 4BABA 1FUQA 1K7WA 3LR6A 1FUPA 5IZ2A 1HQMD 1I3QA 2YU9A 1AUWA 2RJSA 2O7BA 1C3CA 2X75A 3UNVA 4A15A 1GKMA 3R6YA 3EZEA 3TV2A 2BE5D 1SMYD 1K83A 2FENA 1YNJD 2X0QA 1TWHA 3GTPA 1FUOA 2MQAA 3GTOA 2YIIA 5H8WA 1GK3A 1TWAA 3GTGA 2FUSA 4NLEA 2EZBA 1TWGA 2Y0NA 4C5UA 3CRW1 3GTLA 2QVEA 1J3UA 2JA6A 2N1DB 2OHYA 3CZOA 1Y1WA 3QBPA 2X0PA 3R6VA 4ADMA 3NZ4A 2HROA 1C3UA 2MX8A 1Y1VA 2NVXA 4QIWA 2PTRA 4FLCA 1DCNA 4FFXA 4EFCA 2HVGA 3CQZA 1GKJA 1TWFA 2X0OA 4ADLA 4V2RA 2K3QA 1IW7D 2O5JD 4FBSA 1W27A 1YFEA 2O6YA 2FIOA 1XMDA 2R92A 3EZBA 2A69D 3GTMA 1TJUA 5M0IA 1Y2MA 1I50A 2VUMA 3GTJA 2O7FA 1T6JA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 1GK2 A;  5F91 A;  2O78 A;  4V2Q A;  1XWO A;  1TJV A;  3GTD A;  4NSL A;  2PTQ A;  1HY0 A;  2NYN A;  3RD8 A;  3OCF A;  3GZH A;  3KDZ A;  3NO9 A;  2E9F A;  1DOF A;  1TJW A;  4BAA A;  4MX2 A;  4HGV A;  4C5R A;  4APA A;  3BHG A;  1JSW A;  1HY1 A;  1RE5 A;  1YIS A;  5D6B A;  1TJ7 A;  1I0A A;  2NYF A;  1K62 A;  5F92 A;  5EYV A;  1EB4 A;  1KQ7 A;  1FUR A;  2RJR A;  1T6P A;  2O7D A;  3OCE A;  1Q5N A;  3C8T A;  1U16 A;  1B8F A;  2J91 A;  3E04 A;  4CQ5 A;  1U15 A;  2VD6 A;  1YFM A;  3KDY A;  4APB A;  2QGA B;  4EEI A;  2O7E A;  3RRP A;  4C6G A;  4C5S A;  2PFM A;  5HW2 A;  3R6Q A;  2PTS A;  5EYT A;  1VDK A;  4BAB A;  1FUQ A;  1K7W A;  1FUP A;  1AUW A;  2RJS A;  2O7B A;  1C3C A;  2X75 A;  3UNV A;  1GKM A;  3R6Y A;  3TV2 A;  1FUO A;  2YII A;  1GK3 A;  2FUS A;  4NLE A;  4C5U A;  2QVE A;  1J3U A;  2OHY A;  3CZO A;  3QBP A;  3R6V A;  4ADM A;  3NZ4 A;  1C3U A;  2PTR A;  4FLC A;  1DCN A;  4FFX A;  4EFC A;  2HVG A;  1GKJ A;  4ADL A;  4V2R A;  1YFE A;  1W27 A;  2O6Y A;  1TJU A;  1Y2M A;  2O7F A;  1T6J A; 
#chains in the Genus database with same CATH topology
 1GK2 A;  5F91 A;  2O78 A;  4WNL A;  2B63 A;  2JA7 A;  4V2Q A;  1XWO A;  2EZA A;  1XL7 A;  2JA5 A;  1TJV A;  3GTD A;  4NSL A;  2PTQ A;  3LRD A;  2MP0 A;  1HY0 A;  2NYN A;  3RD8 A;  2LPJ A;  3OCF A;  3GZH A;  1XL8 A;  3KDZ A;  2F5J A;  2E9F A;  3NO9 A;  1DOF A;  1TJW A;  1WCM A;  4BAA A;  4MX2 A;  3EZA A;  4HGV A;  3GTQ A;  4C5R A;  4APA A;  3BHG A;  1JSW A;  3U4Q A;  1SFO A;  1HY1 A;  1RE5 A;  1YIS A;  2LPI A;  5D6B A;  2K3N A;  1TJ7 A;  1I0A A;  2E2H A;  2NYF A;  1K62 A;  1EZB A;  2HWG A;  4CEJ A;  2FIP A;  5F92 A;  4CEI A;  5EYV A;  4CEH A;  1EB4 A;  1KQ7 A;  1FUR A;  2CW0 D;  3H0G A;  2RJR A;  2N3E A;  1T6P A;  1ZYR D;  2VSF A;  2A6E D;  1YNN D;  2O7D A;  2EZC A;  3LR8 A;  3GTK A;  1Q5N A;  1XMC A;  3OCE A;  2A6H D;  1XLY A;  1I6V D;  3C8T A;  1U16 A;  1B8F A;  1EZA A;  2VK9 A;  4C2M A;  2LYI A;  2NVY A;  2J91 A;  3E04 A;  2E2I A;  2FEL A;  2VL7 A;  4CQ5 A;  1U15 A;  3CRV A;  3LR2 A;  2VD6 A;  2K3O A;  3U44 A;  1YFM A;  2LTH A;  2LKM B;  3KDY A;  1TWC A;  4APB A;  2A68 D;  2QGA B;  2R93 A;  4EEI A;  2O7E A;  2R7Z A;  1ZYM A;  4C6G A;  3RRP A;  2MX9 A;  3FKI A;  4C5S A;  2PFM A;  1R9T A;  3R6Q A;  5HW2 A;  5M0J A;  2PTS A;  5EYT A;  2AQL A;  1VDK A;  4BAB A;  1FUQ A;  1K7W A;  3LR6 A;  1FUP A;  5IZ2 A;  1HQM D;  1I3Q A;  2YU9 A;  1AUW A;  2RJS A;  2O7B A;  1C3C A;  2X75 A;  3UNV A;  4A15 A;  1GKM A;  3R6Y A;  3EZE A;  3TV2 A;  2BE5 D;  1SMY D;  1K83 A;  2FEN A;  1YNJ D;  2X0Q A;  1TWH A;  3GTP A;  1FUO A;  2MQA A;  3GTO A;  2YII A;  5H8W A;  1GK3 A;  1TWA A;  3GTG A;  2FUS A;  4NLE A;  2EZB A;  1TWG A;  2Y0N A;  4C5U A;  3CRW 1;  3GTL A;  2QVE A;  1J3U A;  2JA6 A;  2N1D B;  2OHY A;  3CZO A;  1Y1W A;  3QBP A;  2X0P A;  3R6V A;  4ADM A;  3NZ4 A;  2HRO A;  1C3U A;  2MX8 A;  1Y1V A;  2NVX A;  4QIW A;  2PTR A;  4FLC A;  1DCN A;  4FFX A;  4EFC A;  2HVG A;  3CQZ A;  1GKJ A;  1TWF A;  2X0O A;  4ADL A;  4V2R A;  2K3Q A;  1IW7 D;  2O5J D;  4FBS A;  1W27 A;  1YFE A;  2O6Y A;  2FIO A;  1XMD A;  2R92 A;  3EZB A;  2A69 D;  3GTM A;  1TJU A;  5M0I A;  1Y2M A;  1I50 A;  2VUM A;  3GTJ A;  2O7F A;  1T6J A; 
#chains in the Genus database with same CATH homology
 1GK2 A;  5F91 A;  2O78 A;  4V2Q A;  1XWO A;  1TJV A;  3GTD A;  4NSL A;  2PTQ A;  1HY0 A;  2NYN A;  3RD8 A;  3OCF A;  3GZH A;  3KDZ A;  3NO9 A;  2E9F A;  1DOF A;  1TJW A;  4BAA A;  4MX2 A;  4HGV A;  4C5R A;  4APA A;  3BHG A;  1JSW A;  1HY1 A;  1RE5 A;  1YIS A;  5D6B A;  1TJ7 A;  1I0A A;  2NYF A;  1K62 A;  5F92 A;  5EYV A;  1EB4 A;  1KQ7 A;  1FUR A;  2RJR A;  1T6P A;  2O7D A;  3OCE A;  1Q5N A;  3C8T A;  1U16 A;  1B8F A;  2J91 A;  3E04 A;  4CQ5 A;  1U15 A;  2VD6 A;  1YFM A;  3KDY A;  4APB A;  2QGA B;  4EEI A;  2O7E A;  3RRP A;  4C6G A;  4C5S A;  2PFM A;  5HW2 A;  3R6Q A;  2PTS A;  5EYT A;  1VDK A;  4BAB A;  1FUQ A;  1K7W A;  1FUP A;  1AUW A;  2RJS A;  2O7B A;  1C3C A;  2X75 A;  3UNV A;  1GKM A;  3R6Y A;  3TV2 A;  1FUO A;  2YII A;  1GK3 A;  2FUS A;  4NLE A;  4C5U A;  2QVE A;  1J3U A;  2OHY A;  3CZO A;  3QBP A;  3R6V A;  4ADM A;  3NZ4 A;  1C3U A;  2PTR A;  4FLC A;  1DCN A;  4FFX A;  4EFC A;  2HVG A;  1GKJ A;  4ADL A;  4V2R A;  1YFE A;  1W27 A;  2O6Y A;  1TJU A;  1Y2M A;  2O7F A;  1T6J A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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4C5RA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations