4C5RA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 264
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
264
sequence length
667
structure length
634
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEACRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
molecule tags Lyase
source organism Taxus wallichiana var. chinensis
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 264
structure length 634
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5rA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5rA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5rA02
1W27A 4NSLA 1J3UA 3TV2A 2X75A 4FFXA 3NZ4A 1TJ7A 3E04A 4C5SA 3GTDA 1K62A 4APBA 2PFMA 1DCNA 3C8TA 2RJRA 2O7FA 1FUQA 3R6VA 4C5UA 1TJVA 2O7DA 1RE5A 1I0AA 3OCEA 1Y2MA 1GKJA 2FUSA 5EYTA 2O78A 2RJSA 1TJWA 2VD6A 5F91A 4ADMA 4C6GA 4V2RA 1JSWA 1FUPA 1U16A 2OHYA 2NYFA 1XWOA 2HVGA 4FLCA 2O7EA 1K7WA 4CQ5A 3RD8A 5F92A 4APAA 4EFCA 4EEIA 1FUOA 2PTQA 1YFMA 4BABA 1B8FA 1GK2A 1HY0A 4C5RA 2PTRA 1T6PA 1TJUA 4NLEA 5D6BA 4ADLA 1AUWA 1GK3A 3CZOA 3QBPA 3UNVA 3R6YA 4BAAA 1FURA 1VDKA 3RRPA 3BHGA 1DOFA 2QGAB 1C3CA 1Q5NA 2QVEA 2O6YA 1EB4A 1YFEA 2E9FA 1T6JA 2NYNA 3R6QA 1HY1A 3GZHA 4MX2A 1GKMA 3NO9A 3OCFA 4V2QA 2J91A 1U15A 5EYVA 5HW2A 1C3UA 3KDZA 2PTSA 2O7BA 1KQ7A 3KDYA 4HGVA 1YISA 2YIIA
chains in the Genus database with same CATH superfamily
3GTJA 1W27A 4NSLA 1J3UA 3TV2A 2X75A 4FFXA 2A68D 1EZAA 2K3NA 1YNND 3U4QA 1Y1WA 3NZ4A 1TJ7A 4FBSA 4C5SA 3E04A 2E2IA 1K62A 2FIOA 3GTDA 4CEHA 2R93A 4APBA 2PFMA 2B63A 1DCNA 1TWCA 2MX8A 2VK9A 3C8TA 2RJRA 2F5JA 2O7FA 1FUQA 3R6VA 3CQZA 4C5UA 1TJVA 4A15A 2AQLA 4WNLA 2O7DA 1RE5A 1I0AA 1XL8A 2VUMA 3OCEA 1XMDA 1Y2MA 1GKJA 2FUSA 5IZ2A 2VSFA 5EYTA 5H8WA 1SFOA 2O78A 1K83A 3CRW1 3H0GA 1XL7A 1I3QA 2RJSA 5M0JA 1TWFA 1TJWA 2VD6A 5F91A 4ADMA 2LPJA 4C6GA 4V2RA 3GTOA 1JSWA 1TWHA 3U44A 1TWGA 3LR6A 1HQMD 1U16A 2OHYA 2NYFA 5M0IA 1XWOA 3LR8A 2X0PA 2HVGA 4FLCA 2O7EA 3EZBA 3LR2A 1K7WA 4CQ5A 3GTQA 4QIWA 2R7ZA 1YISA 3RD8A 5F92A 3EZAA 3GTGA 4APAA 2EZBA 2LKMB 2N3EA 4EFCA 4EEIA 2A6ED 1FUOA 2PTQA 3GTMA 1YFMA 4BABA 2O5JD 1B8FA 1I6VD 2MP0A 1GK2A 1HY0A 4C5RA 1XLYA 2PTRA 1T6PA 2JA5A 1ZYRD 4C2MA 2JA6A 1TJUA 2LYIA 2E2HA 2LTHA 4NLEA 5D6BA 2YU9A 4ADLA 2FENA 1AUWA 2VL7A 1GK3A 3CZOA 3QBPA 3UNVA 3R6YA 2LPIA 4BAAA 1FURA 2K3OA 1R9TA 1VDKA 3RRPA 2BE5D 1ZYMA 3GTLA 2EZCA 3BHGA 1DOFA 2QGAB 1I50A 2R92A 3LRDA 2A69D 1C3CA 2FIPA 1Q5NA 2QVEA 2O6YA 1WCMA 1EB4A 3EZEA 2K3QA 2FELA 1YFEA 2E9FA 1T6JA 2NYNA 3R6QA 1HY1A 2HROA 1TWAA 2NVXA 2N1DB 3GZHA 2A6HD 3GTKA 2X0OA 3GTPA 1EZBA 2HWGA 4MX2A 1SMYD 2X0QA 1YNJD 1Y1VA 1GKMA 3NO9A 3OCFA 2MQAA 3FKIA 4V2QA 2Y0NA 2J91A 1U15A 2MX9A 5EYVA 5HW2A 4CEJA 4CEIA 1C3UA 3CRVA 2NVYA 2JA7A 2EZAA 2CW0D 2O7BA 1KQ7A 2PTSA 1XMCA 3KDYA 3KDZA 4HGVA 1IW7D 1FUPA 2YIIA
chains in the Genus database with same CATH topology
1W27A 4NSLA 1J3UA 3TV2A 2X75A 4FFXA 3NZ4A 1TJ7A 3E04A 4C5SA 3GTDA 1K62A 4APBA 2PFMA 1DCNA 3C8TA 2RJRA 2O7FA 1FUQA 3R6VA 4C5UA 1TJVA 2O7DA 1RE5A 1I0AA 3OCEA 1Y2MA 1GKJA 2FUSA 5EYTA 2O78A 2RJSA 1TJWA 2VD6A 5F91A 4ADMA 4C6GA 4V2RA 1JSWA 1FUPA 1U16A 2OHYA 2NYFA 1XWOA 2HVGA 4FLCA 2O7EA 1K7WA 4CQ5A 3RD8A 5F92A 4APAA 4EFCA 4EEIA 1FUOA 2PTQA 1YFMA 4BABA 1B8FA 1GK2A 1HY0A 4C5RA 2PTRA 1T6PA 1TJUA 4NLEA 5D6BA 4ADLA 1AUWA 1GK3A 3CZOA 3QBPA 3UNVA 3R6YA 4BAAA 1FURA 1VDKA 3RRPA 3BHGA 1DOFA 2QGAB 1C3CA 1Q5NA 2QVEA 2O6YA 1EB4A 1YFEA 2E9FA 1T6JA 2NYNA 3R6QA 1HY1A 3GZHA 4MX2A 1GKMA 3NO9A 3OCFA 4V2QA 2J91A 1U15A 5EYVA 5HW2A 1C3UA 3KDZA 2PTSA 2O7BA 1KQ7A 3KDYA 4HGVA 1YISA 2YIIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1W27 A;  4NSL A;  1J3U A;  3TV2 A;  2X75 A;  4FFX A;  3NZ4 A;  1TJ7 A;  3E04 A;  4C5S A;  3GTD A;  1K62 A;  4APB A;  2PFM A;  1DCN A;  3C8T A;  2RJR A;  2O7F A;  1FUQ A;  3R6V A;  4C5U A;  1TJV A;  2O7D A;  1RE5 A;  1I0A A;  3OCE A;  1Y2M A;  1GKJ A;  2FUS A;  5EYT A;  2O78 A;  2RJS A;  1TJW A;  2VD6 A;  5F91 A;  4ADM A;  4C6G A;  4V2R A;  1JSW A;  1FUP A;  1U16 A;  2OHY A;  2NYF A;  1XWO A;  2HVG A;  4FLC A;  2O7E A;  1K7W A;  4CQ5 A;  3RD8 A;  5F92 A;  4APA A;  4EFC A;  4EEI A;  1FUO A;  2PTQ A;  1YFM A;  4BAB A;  1B8F A;  1GK2 A;  1HY0 A;  4C5R A;  2PTR A;  1T6P A;  1TJU A;  4NLE A;  5D6B A;  4ADL A;  1AUW A;  1GK3 A;  3CZO A;  3QBP A;  3UNV A;  3R6Y A;  4BAA A;  1FUR A;  1VDK A;  3RRP A;  3BHG A;  1DOF A;  2QGA B;  1C3C A;  1Q5N A;  2QVE A;  2O6Y A;  1EB4 A;  1YFE A;  2E9F A;  1T6J A;  2NYN A;  3R6Q A;  1HY1 A;  3GZH A;  4MX2 A;  1GKM A;  3NO9 A;  3OCF A;  4V2Q A;  2J91 A;  1U15 A;  5EYV A;  5HW2 A;  1C3U A;  3KDZ A;  2PTS A;  2O7B A;  1KQ7 A;  3KDY A;  4HGV A;  1YIS A;  2YII A; 
#chains in the Genus database with same CATH topology
 3GTJ A;  1W27 A;  4NSL A;  1J3U A;  3TV2 A;  2X75 A;  4FFX A;  2A68 D;  1EZA A;  2K3N A;  1YNN D;  3U4Q A;  1Y1W A;  3NZ4 A;  1TJ7 A;  4FBS A;  4C5S A;  3E04 A;  2E2I A;  1K62 A;  2FIO A;  3GTD A;  4CEH A;  2R93 A;  4APB A;  2PFM A;  2B63 A;  1DCN A;  1TWC A;  2MX8 A;  2VK9 A;  3C8T A;  2RJR A;  2F5J A;  2O7F A;  1FUQ A;  3R6V A;  3CQZ A;  4C5U A;  1TJV A;  4A15 A;  2AQL A;  4WNL A;  2O7D A;  1RE5 A;  1I0A A;  1XL8 A;  2VUM A;  3OCE A;  1XMD A;  1Y2M A;  1GKJ A;  2FUS A;  5IZ2 A;  2VSF A;  5EYT A;  5H8W A;  1SFO A;  2O78 A;  1K83 A;  3CRW 1;  3H0G A;  1XL7 A;  1I3Q A;  2RJS A;  5M0J A;  1TWF A;  1TJW A;  2VD6 A;  5F91 A;  4ADM A;  2LPJ A;  4C6G A;  4V2R A;  3GTO A;  1JSW A;  1TWH A;  3U44 A;  1TWG A;  3LR6 A;  1HQM D;  1U16 A;  2OHY A;  2NYF A;  5M0I A;  1XWO A;  3LR8 A;  2X0P A;  2HVG A;  4FLC A;  2O7E A;  3EZB A;  3LR2 A;  1K7W A;  4CQ5 A;  3GTQ A;  4QIW A;  2R7Z A;  1YIS A;  3RD8 A;  5F92 A;  3EZA A;  3GTG A;  4APA A;  2EZB A;  2LKM B;  2N3E A;  4EFC A;  4EEI A;  2A6E D;  1FUO A;  2PTQ A;  3GTM A;  1YFM A;  4BAB A;  2O5J D;  1B8F A;  1I6V D;  2MP0 A;  1GK2 A;  1HY0 A;  4C5R A;  1XLY A;  2PTR A;  1T6P A;  2JA5 A;  1ZYR D;  4C2M A;  2JA6 A;  1TJU A;  2LYI A;  2E2H A;  2LTH A;  4NLE A;  5D6B A;  2YU9 A;  4ADL A;  2FEN A;  1AUW A;  2VL7 A;  1GK3 A;  3CZO A;  3QBP A;  3UNV A;  3R6Y A;  2LPI A;  4BAA A;  1FUR A;  2K3O A;  1R9T A;  1VDK A;  3RRP A;  2BE5 D;  1ZYM A;  3GTL A;  2EZC A;  3BHG A;  1DOF A;  2QGA B;  1I50 A;  2R92 A;  3LRD A;  2A69 D;  1C3C A;  2FIP A;  1Q5N A;  2QVE A;  2O6Y A;  1WCM A;  1EB4 A;  3EZE A;  2K3Q A;  2FEL A;  1YFE A;  2E9F A;  1T6J A;  2NYN A;  3R6Q A;  1HY1 A;  2HRO A;  1TWA A;  2NVX A;  2N1D B;  3GZH A;  2A6H D;  3GTK A;  2X0O A;  3GTP A;  1EZB A;  2HWG A;  4MX2 A;  1SMY D;  2X0Q A;  1YNJ D;  1Y1V A;  1GKM A;  3NO9 A;  3OCF A;  2MQA A;  3FKI A;  4V2Q A;  2Y0N A;  2J91 A;  1U15 A;  2MX9 A;  5EYV A;  5HW2 A;  4CEJ A;  4CEI A;  1C3U A;  3CRV A;  2NVY A;  2JA7 A;  2EZA A;  2CW0 D;  2O7B A;  1KQ7 A;  2PTS A;  1XMC A;  3KDY A;  3KDZ A;  4HGV A;  1IW7 D;  1FUP A;  2YII A; 
#chains in the Genus database with same CATH homology
 1W27 A;  4NSL A;  1J3U A;  3TV2 A;  2X75 A;  4FFX A;  3NZ4 A;  1TJ7 A;  3E04 A;  4C5S A;  3GTD A;  1K62 A;  4APB A;  2PFM A;  1DCN A;  3C8T A;  2RJR A;  2O7F A;  1FUQ A;  3R6V A;  4C5U A;  1TJV A;  2O7D A;  1RE5 A;  1I0A A;  3OCE A;  1Y2M A;  1GKJ A;  2FUS A;  5EYT A;  2O78 A;  2RJS A;  1TJW A;  2VD6 A;  5F91 A;  4ADM A;  4C6G A;  4V2R A;  1JSW A;  1FUP A;  1U16 A;  2OHY A;  2NYF A;  1XWO A;  2HVG A;  4FLC A;  2O7E A;  1K7W A;  4CQ5 A;  3RD8 A;  5F92 A;  4APA A;  4EFC A;  4EEI A;  1FUO A;  2PTQ A;  1YFM A;  4BAB A;  1B8F A;  1GK2 A;  1HY0 A;  4C5R A;  2PTR A;  1T6P A;  1TJU A;  4NLE A;  5D6B A;  4ADL A;  1AUW A;  1GK3 A;  3CZO A;  3QBP A;  3UNV A;  3R6Y A;  4BAA A;  1FUR A;  1VDK A;  3RRP A;  3BHG A;  1DOF A;  2QGA B;  1C3C A;  1Q5N A;  2QVE A;  2O6Y A;  1EB4 A;  1YFE A;  2E9F A;  1T6J A;  2NYN A;  3R6Q A;  1HY1 A;  3GZH A;  4MX2 A;  1GKM A;  3NO9 A;  3OCF A;  4V2Q A;  2J91 A;  1U15 A;  5EYV A;  5HW2 A;  1C3U A;  3KDZ A;  2PTS A;  2O7B A;  1KQ7 A;  3KDY A;  4HGV A;  1YIS A;  2YII A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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