4C5RA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 264
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
264
sequence length
667
structure length
634
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEACRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
molecule tags Lyase
source organism Taxus wallichiana var. chinensis
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 264
structure length 634
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5rA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5rA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5rA02
4FFXA 4MX2A 1TJWA 4APAA 5HW2A 1RE5A 3RRPA 3R6YA 4FLCA 1XWOA 1J3UA 4CQ5A 2NYNA 2QVEA 2OHYA 2O6YA 5D6BA 3R6QA 2O7FA 1GK2A 1HY1A 3NO9A 4ADMA 4NLEA 4V2QA 5EYTA 3QBPA 1T6JA 1DCNA 4BABA 1AUWA 2PTRA 3R6VA 1I0AA 2RJRA 1EB4A 3KDYA 3GZHA 3NZ4A 3BHGA 1JSWA 1FUQA 3TV2A 1KQ7A 3OCFA 2RJSA 1K7WA 1T6PA 2PFMA 4HGVA 2X75A 1FUPA 4C5SA 1C3CA 1FURA 4NSLA 2J91A 1VDKA 2HVGA 5F92A 3RD8A 1TJUA 2O7EA 2O7DA 2NYFA 1B8FA 4EEIA 1YFMA 4C5UA 1DOFA 5F91A 1Q5NA 1YFEA 4V2RA 4ADLA 1C3UA 3KDZA 4C6GA 2E9FA 2PTSA 5EYVA 4EFCA 1U16A 2YIIA 2O7BA 1K62A 1GKMA 2O78A 1Y2MA 1GKJA 2QGAB 2VD6A 3CZOA 2PTQA 1TJ7A 4BAAA 4APBA 2FUSA 3E04A 3OCEA 3C8TA 3GTDA 4C5RA 1HY0A 1FUOA 3UNVA 1TJVA 1YISA 1GK3A 1W27A 1U15A
chains in the Genus database with same CATH superfamily
4FFXA 4MX2A 5M0JA 2YU9A 2JA5A 1XMCA 1TJWA 4APAA 3CRW1 2BE5D 4FBSA 5HW2A 5M0IA 2EZAA 1RE5A 3GTGA 2VUMA 3RRPA 2E2HA 3R6YA 4FLCA 2X0QA 1XWOA 1J3UA 1TWCA 4CQ5A 2NYNA 2QVEA 2OHYA 2O6YA 2EZBA 1ZYRD 5D6BA 1TWHA 3R6QA 2FELA 2MP0A 2O7FA 2CW0D 3EZAA 1GK2A 3LRDA 2VL7A 1HY1A 2FIPA 3NO9A 4ADMA 3EZEA 4NLEA 4V2QA 5IZ2A 5EYTA 3QBPA 1SMYD 1T6JA 1DCNA 3CRVA 2VK9A 2R93A 4BABA 1AUWA 1SFOA 2X0PA 2PTRA 3U4QA 3LR2A 2Y0NA 3R6VA 1TWFA 1I3QA 1I0AA 1HQMD 2RJRA 1EB4A 3KDYA 3FKIA 3GZHA 3NZ4A 3BHGA 1EZBA 1JSWA 1FUQA 3GTJA 1KQ7A 3OCFA 3TV2A 2RJSA 2K3NA 2R7ZA 4WNLA 1K7WA 1T6PA 3LR6A 2K3OA 2PFMA 4C2MA 4HGVA 2X75A 1FUPA 2LYIA 4A15A 2R92A 2LTHA 4C5SA 2MX9A 1C3CA 1TWAA 1EZAA 1FURA 2F5JA 4NSLA 2J91A 3CQZA 1VDKA 2HVGA 2MX8A 5F92A 1XMDA 3RD8A 2K3QA 2N1DB 2A6HD 1TJUA 2X0OA 2O7EA 2O7DA 2NYFA 3GTOA 1B8FA 4EEIA 1YFMA 4C5UA 2JA6A 1K83A 1DOFA 5F91A 1Q5NA 1XL7A 1YFEA 3GTQA 1Y1VA 4V2RA 3U44A 1TWGA 4ADLA 5H8WA 1C3UA 1WCMA 4C6GA 3KDZA 2E9FA 2FENA 2PTSA 2N3EA 2LKMB 5EYVA 2A68D 4EFCA 2E2IA 2AQLA 1U16A 2LPJA 2YIIA 4CEIA 2O7BA 1K62A 1I6VD 1GKMA 2B63A 1Y2MA 2O78A 1Y1WA 2A6ED 1XL8A 1GKJA 4QIWA 2A69D 2QGAB 2FIOA 3GTLA 2VD6A 2HROA 4CEJA 3CZOA 1R9TA 2O5JD 2JA7A 3EZBA 3GTPA 1I50A 2NVXA 1TJ7A 2PTQA 2MQAA 4BAAA 4APBA 2FUSA 2LPIA 3E04A 3GTMA 4CEHA 2NVYA 3GTKA 3C8TA 1YNJD 2VSFA 3OCEA 1XLYA 3GTDA 1IW7D 2HWGA 4C5RA 1HY0A 1FUOA 3UNVA 1TJVA 1YISA 1YNND 1ZYMA 3LR8A 1GK3A 2EZCA 3H0GA 1W27A 1U15A
chains in the Genus database with same CATH topology
4FFXA 4MX2A 1TJWA 4APAA 5HW2A 1RE5A 3RRPA 3R6YA 4FLCA 1XWOA 1J3UA 4CQ5A 2NYNA 2QVEA 2OHYA 2O6YA 5D6BA 3R6QA 2O7FA 1GK2A 1HY1A 3NO9A 4ADMA 4NLEA 4V2QA 5EYTA 3QBPA 1T6JA 1DCNA 4BABA 1AUWA 2PTRA 3R6VA 1I0AA 2RJRA 1EB4A 3KDYA 3GZHA 3NZ4A 3BHGA 1JSWA 1FUQA 3TV2A 1KQ7A 3OCFA 2RJSA 1K7WA 1T6PA 2PFMA 4HGVA 2X75A 1FUPA 4C5SA 1C3CA 1FURA 4NSLA 2J91A 1VDKA 2HVGA 5F92A 3RD8A 1TJUA 2O7EA 2O7DA 2NYFA 1B8FA 4EEIA 1YFMA 4C5UA 1DOFA 5F91A 1Q5NA 1YFEA 4V2RA 4ADLA 1C3UA 3KDZA 4C6GA 2E9FA 2PTSA 5EYVA 4EFCA 1U16A 2YIIA 2O7BA 1K62A 1GKMA 2O78A 1Y2MA 1GKJA 2QGAB 2VD6A 3CZOA 2PTQA 1TJ7A 4BAAA 4APBA 2FUSA 3E04A 3OCEA 3C8TA 3GTDA 4C5RA 1HY0A 1FUOA 3UNVA 1TJVA 1YISA 1GK3A 1W27A 1U15A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FFX A;  4MX2 A;  1TJW A;  4APA A;  5HW2 A;  1RE5 A;  3RRP A;  3R6Y A;  4FLC A;  1XWO A;  1J3U A;  4CQ5 A;  2NYN A;  2QVE A;  2OHY A;  2O6Y A;  5D6B A;  3R6Q A;  2O7F A;  1GK2 A;  1HY1 A;  3NO9 A;  4ADM A;  4NLE A;  4V2Q A;  5EYT A;  3QBP A;  1T6J A;  1DCN A;  4BAB A;  1AUW A;  2PTR A;  3R6V A;  1I0A A;  2RJR A;  1EB4 A;  3KDY A;  3GZH A;  3NZ4 A;  3BHG A;  1JSW A;  1FUQ A;  3TV2 A;  1KQ7 A;  3OCF A;  2RJS A;  1K7W A;  1T6P A;  2PFM A;  4HGV A;  2X75 A;  1FUP A;  4C5S A;  1C3C A;  1FUR A;  4NSL A;  2J91 A;  1VDK A;  2HVG A;  5F92 A;  3RD8 A;  1TJU A;  2O7E A;  2O7D A;  2NYF A;  1B8F A;  4EEI A;  1YFM A;  4C5U A;  1DOF A;  5F91 A;  1Q5N A;  1YFE A;  4V2R A;  4ADL A;  1C3U A;  3KDZ A;  4C6G A;  2E9F A;  2PTS A;  5EYV A;  4EFC A;  1U16 A;  2YII A;  2O7B A;  1K62 A;  1GKM A;  2O78 A;  1Y2M A;  1GKJ A;  2QGA B;  2VD6 A;  3CZO A;  2PTQ A;  1TJ7 A;  4BAA A;  4APB A;  2FUS A;  3E04 A;  3OCE A;  3C8T A;  3GTD A;  4C5R A;  1HY0 A;  1FUO A;  3UNV A;  1TJV A;  1YIS A;  1GK3 A;  1W27 A;  1U15 A; 
#chains in the Genus database with same CATH topology
 4FFX A;  4MX2 A;  5M0J A;  2YU9 A;  2JA5 A;  1XMC A;  1TJW A;  4APA A;  3CRW 1;  2BE5 D;  4FBS A;  5HW2 A;  5M0I A;  2EZA A;  1RE5 A;  3GTG A;  2VUM A;  3RRP A;  2E2H A;  3R6Y A;  4FLC A;  2X0Q A;  1XWO A;  1J3U A;  1TWC A;  4CQ5 A;  2NYN A;  2QVE A;  2OHY A;  2O6Y A;  2EZB A;  1ZYR D;  5D6B A;  1TWH A;  3R6Q A;  2FEL A;  2MP0 A;  2O7F A;  2CW0 D;  3EZA A;  1GK2 A;  3LRD A;  2VL7 A;  1HY1 A;  2FIP A;  3NO9 A;  4ADM A;  3EZE A;  4NLE A;  4V2Q A;  5IZ2 A;  5EYT A;  3QBP A;  1SMY D;  1T6J A;  1DCN A;  3CRV A;  2VK9 A;  2R93 A;  4BAB A;  1AUW A;  1SFO A;  2X0P A;  2PTR A;  3U4Q A;  3LR2 A;  2Y0N A;  3R6V A;  1TWF A;  1I3Q A;  1I0A A;  1HQM D;  2RJR A;  1EB4 A;  3KDY A;  3FKI A;  3GZH A;  3NZ4 A;  3BHG A;  1EZB A;  1JSW A;  1FUQ A;  3GTJ A;  1KQ7 A;  3OCF A;  3TV2 A;  2RJS A;  2K3N A;  2R7Z A;  4WNL A;  1K7W A;  1T6P A;  3LR6 A;  2K3O A;  2PFM A;  4C2M A;  4HGV A;  2X75 A;  1FUP A;  2LYI A;  4A15 A;  2R92 A;  2LTH A;  4C5S A;  2MX9 A;  1C3C A;  1TWA A;  1EZA A;  1FUR A;  2F5J A;  4NSL A;  2J91 A;  3CQZ A;  1VDK A;  2HVG A;  2MX8 A;  5F92 A;  1XMD A;  3RD8 A;  2K3Q A;  2N1D B;  2A6H D;  1TJU A;  2X0O A;  2O7E A;  2O7D A;  2NYF A;  3GTO A;  1B8F A;  4EEI A;  1YFM A;  4C5U A;  2JA6 A;  1K83 A;  1DOF A;  5F91 A;  1Q5N A;  1XL7 A;  1YFE A;  3GTQ A;  1Y1V A;  4V2R A;  3U44 A;  1TWG A;  4ADL A;  5H8W A;  1C3U A;  1WCM A;  4C6G A;  3KDZ A;  2E9F A;  2FEN A;  2PTS A;  2N3E A;  2LKM B;  5EYV A;  2A68 D;  4EFC A;  2E2I A;  2AQL A;  1U16 A;  2LPJ A;  2YII A;  4CEI A;  2O7B A;  1K62 A;  1I6V D;  1GKM A;  2B63 A;  1Y2M A;  2O78 A;  1Y1W A;  2A6E D;  1XL8 A;  1GKJ A;  4QIW A;  2A69 D;  2QGA B;  2FIO A;  3GTL A;  2VD6 A;  2HRO A;  4CEJ A;  3CZO A;  1R9T A;  2O5J D;  2JA7 A;  3EZB A;  3GTP A;  1I50 A;  2NVX A;  1TJ7 A;  2PTQ A;  2MQA A;  4BAA A;  4APB A;  2FUS A;  2LPI A;  3E04 A;  3GTM A;  4CEH A;  2NVY A;  3GTK A;  3C8T A;  1YNJ D;  2VSF A;  3OCE A;  1XLY A;  3GTD A;  1IW7 D;  2HWG A;  4C5R A;  1HY0 A;  1FUO A;  3UNV A;  1TJV A;  1YIS A;  1YNN D;  1ZYM A;  3LR8 A;  1GK3 A;  2EZC A;  3H0G A;  1W27 A;  1U15 A; 
#chains in the Genus database with same CATH homology
 4FFX A;  4MX2 A;  1TJW A;  4APA A;  5HW2 A;  1RE5 A;  3RRP A;  3R6Y A;  4FLC A;  1XWO A;  1J3U A;  4CQ5 A;  2NYN A;  2QVE A;  2OHY A;  2O6Y A;  5D6B A;  3R6Q A;  2O7F A;  1GK2 A;  1HY1 A;  3NO9 A;  4ADM A;  4NLE A;  4V2Q A;  5EYT A;  3QBP A;  1T6J A;  1DCN A;  4BAB A;  1AUW A;  2PTR A;  3R6V A;  1I0A A;  2RJR A;  1EB4 A;  3KDY A;  3GZH A;  3NZ4 A;  3BHG A;  1JSW A;  1FUQ A;  3TV2 A;  1KQ7 A;  3OCF A;  2RJS A;  1K7W A;  1T6P A;  2PFM A;  4HGV A;  2X75 A;  1FUP A;  4C5S A;  1C3C A;  1FUR A;  4NSL A;  2J91 A;  1VDK A;  2HVG A;  5F92 A;  3RD8 A;  1TJU A;  2O7E A;  2O7D A;  2NYF A;  1B8F A;  4EEI A;  1YFM A;  4C5U A;  1DOF A;  5F91 A;  1Q5N A;  1YFE A;  4V2R A;  4ADL A;  1C3U A;  3KDZ A;  4C6G A;  2E9F A;  2PTS A;  5EYV A;  4EFC A;  1U16 A;  2YII A;  2O7B A;  1K62 A;  1GKM A;  2O78 A;  1Y2M A;  1GKJ A;  2QGA B;  2VD6 A;  3CZO A;  2PTQ A;  1TJ7 A;  4BAA A;  4APB A;  2FUS A;  3E04 A;  3OCE A;  3C8T A;  3GTD A;  4C5R A;  1HY0 A;  1FUO A;  3UNV A;  1TJV A;  1YIS A;  1GK3 A;  1W27 A;  1U15 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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