4C5SA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 267
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
267
sequence length
667
structure length
638
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIAGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHTDTLVDRLAEFEKRLSDRLENEMTAVRVLYEVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
molecule tags Lyase
source organism Taxus wallichiana var. chinensis
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 267
structure length 638
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5sA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5sA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5sA02
1FUOA 1YFMA 1I0AA 3CZOA 2PTRA 1RE5A 3C8TA 3OCFA 3TV2A 4ADLA 1YFEA 1JSWA 3R6VA 2FUSA 1DCNA 2PTSA 3E04A 1EB4A 1FUQA 5HW2A 1T6JA 3R6QA 2O7EA 4C6GA 4FLCA 5F92A 4CQ5A 4C5SA 1K7WA 2NYNA 1GKJA 2PFMA 4HGVA 3R6YA 4FFXA 1B8FA 2O7BA 1U15A 1HY0A 1GK2A 4MX2A 3GTDA 1K62A 4BAAA 1C3UA 1GK3A 1FUPA 4ADMA 3RRPA 1J3UA 2E9FA 1AUWA 2NYFA 4NLEA 4APBA 1Y2MA 3RD8A 1GKMA 2J91A 1HY1A 2RJRA 4C5UA 3OCEA 4V2QA 3NO9A 3QBPA 2YIIA 1U16A 4EEIA 2QGAB 1XWOA 4C5RA 2HVGA 2VD6A 1TJVA 5EYVA 1TJ7A 1YISA 2O7FA 4V2RA 5EYTA 2RJSA 2OHYA 2O78A 5D6BA 1VDKA 1TJUA 1DOFA 4BABA 1TJWA 2O7DA 4NSLA 2PTQA 1C3CA 4EFCA 3NZ4A 3KDYA 3BHGA 1W27A 3KDZA 2O6YA 4APAA 1T6PA 1KQ7A 1Q5NA 5F91A 3UNVA 2X75A 2QVEA 3GZHA 1FURA
chains in the Genus database with same CATH superfamily
1FUOA 1ZYMA 1YFMA 1I0AA 3EZBA 2HWGA 2K3QA 3CZOA 2FIOA 2YU9A 3CRVA 2E2IA 2PTRA 3FKIA 1RE5A 3C8TA 3GTLA 3OCFA 3TV2A 5M0JA 4ADLA 2MP0A 3U4QA 2X0PA 2K3OA 2NVXA 1YFEA 1JSWA 3R6VA 1TWFA 2K3NA 1DCNA 2FUSA 2PTSA 1EB4A 3E04A 1FUQA 4CEIA 2MQAA 5HW2A 2CW0D 1I3QA 1T6JA 3R6QA 2O7EA 4C6GA 2N3EA 4FLCA 5H8WA 5F92A 1XLYA 4CQ5A 3LR6A 3CRW1 1YNJD 4C5SA 1K7WA 1TWAA 2LTHA 1SMYD 2NYNA 2A6ED 1GKJA 2PFMA 4HGVA 3R6YA 2MX9A 4FFXA 1B8FA 2O7BA 1U15A 2EZBA 2JA5A 1HY0A 2X0QA 2A68D 1GK2A 5M0IA 4MX2A 3GTDA 1K62A 4BAAA 1C3UA 1GK3A 2B63A 1FUPA 3GTJA 3GTGA 2HROA 4ADMA 2X0OA 1Y1VA 2E9FA 1J3UA 3RRPA 2FELA 2NVYA 1AUWA 2NYFA 4NLEA 4WNLA 4APBA 2JA6A 1Y2MA 3GTKA 2VL7A 2EZAA 1TWHA 1IW7D 3RD8A 1GKMA 1EZAA 1YNND 2J91A 2VK9A 1HY1A 2BE5D 2RJRA 4A15A 1I50A 3LRDA 2JA7A 4C5UA 2LKMB 2MX8A 4FBSA 3OCEA 4V2QA 3NO9A 1TWGA 2LYIA 5IZ2A 1XL8A 2YIIA 3QBPA 1K83A 3H0GA 3LR2A 2AQLA 2Y0NA 1U16A 4EEIA 2FENA 1HQMD 2LPJA 2QGAB 2A69D 1XWOA 4C5RA 1XMDA 2HVGA 2VD6A 1Y1WA 3GTOA 1TJVA 5EYVA 4CEJA 1TJ7A 2E2HA 1YISA 2O7FA 4QIWA 3GTPA 3U44A 3LR8A 1ZYRD 4V2RA 5EYTA 2RJSA 1XL7A 2O5JD 2O78A 2OHYA 3EZEA 1I6VD 5D6BA 1VDKA 3EZAA 2EZCA 3GTQA 2N1DB 3CQZA 1TJUA 2R92A 1XMCA 1R9TA 1DOFA 2FIPA 4BABA 1TJWA 2O7DA 1EZBA 4NSLA 2PTQA 1C3CA 2LPIA 2VUMA 2R93A 1TWCA 4EFCA 1SFOA 3NZ4A 3KDYA 3GTMA 2F5JA 1WCMA 3BHGA 1W27A 3KDZA 2VSFA 2R7ZA 2O6YA 4C2MA 1T6PA 4APAA 2A6HD 1KQ7A 1Q5NA 5F91A 3UNVA 2X75A 2QVEA 3GZHA 4CEHA 1FURA
chains in the Genus database with same CATH topology
1FUOA 1YFMA 1I0AA 3CZOA 2PTRA 1RE5A 3C8TA 3OCFA 3TV2A 4ADLA 1YFEA 1JSWA 3R6VA 2FUSA 1DCNA 2PTSA 3E04A 1EB4A 1FUQA 5HW2A 1T6JA 3R6QA 2O7EA 4C6GA 4FLCA 5F92A 4CQ5A 4C5SA 1K7WA 2NYNA 1GKJA 2PFMA 4HGVA 3R6YA 4FFXA 1B8FA 2O7BA 1U15A 1HY0A 1GK2A 4MX2A 3GTDA 1K62A 4BAAA 1C3UA 1GK3A 1FUPA 4ADMA 3RRPA 1J3UA 2E9FA 1AUWA 2NYFA 4NLEA 4APBA 1Y2MA 3RD8A 1GKMA 2J91A 1HY1A 2RJRA 4C5UA 3OCEA 4V2QA 3NO9A 3QBPA 2YIIA 1U16A 4EEIA 2QGAB 1XWOA 4C5RA 2HVGA 2VD6A 1TJVA 5EYVA 1TJ7A 1YISA 2O7FA 4V2RA 5EYTA 2RJSA 2OHYA 2O78A 5D6BA 1VDKA 1TJUA 1DOFA 4BABA 1TJWA 2O7DA 4NSLA 2PTQA 1C3CA 4EFCA 3NZ4A 3KDYA 3BHGA 1W27A 3KDZA 2O6YA 4APAA 1T6PA 1KQ7A 1Q5NA 5F91A 3UNVA 2X75A 2QVEA 3GZHA 1FURA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FUO A;  1YFM A;  1I0A A;  3CZO A;  2PTR A;  1RE5 A;  3C8T A;  3OCF A;  3TV2 A;  4ADL A;  1YFE A;  1JSW A;  3R6V A;  2FUS A;  1DCN A;  2PTS A;  3E04 A;  1EB4 A;  1FUQ A;  5HW2 A;  1T6J A;  3R6Q A;  2O7E A;  4C6G A;  4FLC A;  5F92 A;  4CQ5 A;  4C5S A;  1K7W A;  2NYN A;  1GKJ A;  2PFM A;  4HGV A;  3R6Y A;  4FFX A;  1B8F A;  2O7B A;  1U15 A;  1HY0 A;  1GK2 A;  4MX2 A;  3GTD A;  1K62 A;  4BAA A;  1C3U A;  1GK3 A;  1FUP A;  4ADM A;  3RRP A;  1J3U A;  2E9F A;  1AUW A;  2NYF A;  4NLE A;  4APB A;  1Y2M A;  3RD8 A;  1GKM A;  2J91 A;  1HY1 A;  2RJR A;  4C5U A;  3OCE A;  4V2Q A;  3NO9 A;  3QBP A;  2YII A;  1U16 A;  4EEI A;  2QGA B;  1XWO A;  4C5R A;  2HVG A;  2VD6 A;  1TJV A;  5EYV A;  1TJ7 A;  1YIS A;  2O7F A;  4V2R A;  5EYT A;  2RJS A;  2OHY A;  2O78 A;  5D6B A;  1VDK A;  1TJU A;  1DOF A;  4BAB A;  1TJW A;  2O7D A;  4NSL A;  2PTQ A;  1C3C A;  4EFC A;  3NZ4 A;  3KDY A;  3BHG A;  1W27 A;  3KDZ A;  2O6Y A;  4APA A;  1T6P A;  1KQ7 A;  1Q5N A;  5F91 A;  3UNV A;  2X75 A;  2QVE A;  3GZH A;  1FUR A; 
#chains in the Genus database with same CATH topology
 1FUO A;  1ZYM A;  1YFM A;  1I0A A;  3EZB A;  2HWG A;  2K3Q A;  3CZO A;  2FIO A;  2YU9 A;  3CRV A;  2E2I A;  2PTR A;  3FKI A;  1RE5 A;  3C8T A;  3GTL A;  3OCF A;  3TV2 A;  5M0J A;  4ADL A;  2MP0 A;  3U4Q A;  2X0P A;  2K3O A;  2NVX A;  1YFE A;  1JSW A;  3R6V A;  1TWF A;  2K3N A;  1DCN A;  2FUS A;  2PTS A;  1EB4 A;  3E04 A;  1FUQ A;  4CEI A;  2MQA A;  5HW2 A;  2CW0 D;  1I3Q A;  1T6J A;  3R6Q A;  2O7E A;  4C6G A;  2N3E A;  4FLC A;  5H8W A;  5F92 A;  1XLY A;  4CQ5 A;  3LR6 A;  3CRW 1;  1YNJ D;  4C5S A;  1K7W A;  1TWA A;  2LTH A;  1SMY D;  2NYN A;  2A6E D;  1GKJ A;  2PFM A;  4HGV A;  3R6Y A;  2MX9 A;  4FFX A;  1B8F A;  2O7B A;  1U15 A;  2EZB A;  2JA5 A;  1HY0 A;  2X0Q A;  2A68 D;  1GK2 A;  5M0I A;  4MX2 A;  3GTD A;  1K62 A;  4BAA A;  1C3U A;  1GK3 A;  2B63 A;  1FUP A;  3GTJ A;  3GTG A;  2HRO A;  4ADM A;  2X0O A;  1Y1V A;  2E9F A;  1J3U A;  3RRP A;  2FEL A;  2NVY A;  1AUW A;  2NYF A;  4NLE A;  4WNL A;  4APB A;  2JA6 A;  1Y2M A;  3GTK A;  2VL7 A;  2EZA A;  1TWH A;  1IW7 D;  3RD8 A;  1GKM A;  1EZA A;  1YNN D;  2J91 A;  2VK9 A;  1HY1 A;  2BE5 D;  2RJR A;  4A15 A;  1I50 A;  3LRD A;  2JA7 A;  4C5U A;  2LKM B;  2MX8 A;  4FBS A;  3OCE A;  4V2Q A;  3NO9 A;  1TWG A;  2LYI A;  5IZ2 A;  1XL8 A;  2YII A;  3QBP A;  1K83 A;  3H0G A;  3LR2 A;  2AQL A;  2Y0N A;  1U16 A;  4EEI A;  2FEN A;  1HQM D;  2LPJ A;  2QGA B;  2A69 D;  1XWO A;  4C5R A;  1XMD A;  2HVG A;  2VD6 A;  1Y1W A;  3GTO A;  1TJV A;  5EYV A;  4CEJ A;  1TJ7 A;  2E2H A;  1YIS A;  2O7F A;  4QIW A;  3GTP A;  3U44 A;  3LR8 A;  1ZYR D;  4V2R A;  5EYT A;  2RJS A;  1XL7 A;  2O5J D;  2O78 A;  2OHY A;  3EZE A;  1I6V D;  5D6B A;  1VDK A;  3EZA A;  2EZC A;  3GTQ A;  2N1D B;  3CQZ A;  1TJU A;  2R92 A;  1XMC A;  1R9T A;  1DOF A;  2FIP A;  4BAB A;  1TJW A;  2O7D A;  1EZB A;  4NSL A;  2PTQ A;  1C3C A;  2LPI A;  2VUM A;  2R93 A;  1TWC A;  4EFC A;  1SFO A;  3NZ4 A;  3KDY A;  3GTM A;  2F5J A;  1WCM A;  3BHG A;  1W27 A;  3KDZ A;  2VSF A;  2R7Z A;  2O6Y A;  4C2M A;  1T6P A;  4APA A;  2A6H D;  1KQ7 A;  1Q5N A;  5F91 A;  3UNV A;  2X75 A;  2QVE A;  3GZH A;  4CEH A;  1FUR A; 
#chains in the Genus database with same CATH homology
 1FUO A;  1YFM A;  1I0A A;  3CZO A;  2PTR A;  1RE5 A;  3C8T A;  3OCF A;  3TV2 A;  4ADL A;  1YFE A;  1JSW A;  3R6V A;  2FUS A;  1DCN A;  2PTS A;  3E04 A;  1EB4 A;  1FUQ A;  5HW2 A;  1T6J A;  3R6Q A;  2O7E A;  4C6G A;  4FLC A;  5F92 A;  4CQ5 A;  4C5S A;  1K7W A;  2NYN A;  1GKJ A;  2PFM A;  4HGV A;  3R6Y A;  4FFX A;  1B8F A;  2O7B A;  1U15 A;  1HY0 A;  1GK2 A;  4MX2 A;  3GTD A;  1K62 A;  4BAA A;  1C3U A;  1GK3 A;  1FUP A;  4ADM A;  3RRP A;  1J3U A;  2E9F A;  1AUW A;  2NYF A;  4NLE A;  4APB A;  1Y2M A;  3RD8 A;  1GKM A;  2J91 A;  1HY1 A;  2RJR A;  4C5U A;  3OCE A;  4V2Q A;  3NO9 A;  3QBP A;  2YII A;  1U16 A;  4EEI A;  2QGA B;  1XWO A;  4C5R A;  2HVG A;  2VD6 A;  1TJV A;  5EYV A;  1TJ7 A;  1YIS A;  2O7F A;  4V2R A;  5EYT A;  2RJS A;  2OHY A;  2O78 A;  5D6B A;  1VDK A;  1TJU A;  1DOF A;  4BAB A;  1TJW A;  2O7D A;  4NSL A;  2PTQ A;  1C3C A;  4EFC A;  3NZ4 A;  3KDY A;  3BHG A;  1W27 A;  3KDZ A;  2O6Y A;  4APA A;  1T6P A;  1KQ7 A;  1Q5N A;  5F91 A;  3UNV A;  2X75 A;  2QVE A;  3GZH A;  1FUR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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