4C5UA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 255
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
255
sequence length
669
structure length
641
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTKVDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSASGDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRAALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHKDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
molecule tags Lyase
source organism Taxus wallichiana var. chinensis
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 255
structure length 641
sequence length 669
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c5uA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c5uA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c5uA02
1I0AA 3RD8A 1FURA 1EB4A 3OCEA 1TJWA 3C8TA 3KDYA 2J91A 4MX2A 4NLEA 2PTSA 1TJVA 3QBPA 1GK2A 5F91A 5F92A 1W27A 1C3CA 2O7EA 4ADLA 2NYFA 1K7WA 1FUQA 1VDKA 1U15A 2PFMA 1GK3A 1HY1A 3GTDA 4APBA 4NSLA 2PTRA 1TJ7A 2O7DA 1YFMA 3BHGA 3UNVA 1K62A 2RJRA 1U16A 2QVEA 1J3UA 4C5SA 1T6PA 1YFEA 5EYTA 1RE5A 2X75A 1AUWA 1B8FA 4V2QA 4ADMA 1Y2MA 2O7BA 3OCFA 4EFCA 2NYNA 2E9FA 3RRPA 4APAA 4BABA 3R6QA 2YIIA 1T6JA 3CZOA 4V2RA 4C6GA 4C5RA 4FLCA 3GZHA 4FFXA 1FUOA 2O78A 5HW2A 1YISA 2O6YA 2PTQA 4HGVA 3NO9A 3TV2A 1Q5NA 1HY0A 4C5UA 2FUSA 1GKJA 1XWOA 1FUPA 3NZ4A 5D6BA 1KQ7A 5EYVA 4BAAA 3KDZA 3E04A 4EEIA 3R6VA 2OHYA 2HVGA 2VD6A 1DOFA 2O7FA 1JSWA 1DCNA 1TJUA 3R6YA 4CQ5A 2QGAB 1C3UA 1GKMA 2RJSA
chains in the Genus database with same CATH superfamily
4CEHA 2FENA 3GTLA 2FIPA 2VK9A 2YU9A 2R7ZA 2MX9A 3GTGA 1I0AA 3RD8A 2MP0A 5H8WA 2VSFA 1FURA 3H0GA 1EB4A 2A68D 3OCEA 4WNLA 2LYIA 3CQZA 1TJWA 1Y1VA 3C8TA 3KDYA 2J91A 3LRDA 1IW7D 2A6ED 2K3OA 2PTSA 4MX2A 4NLEA 2O5JD 3LR2A 1TJVA 3QBPA 1K83A 2K3QA 1GK2A 5F91A 2K3NA 5F92A 1W27A 3GTMA 3EZEA 3U44A 1C3CA 2O7EA 1R9TA 4ADLA 1TWAA 2NYFA 5M0JA 1K7WA 1FUQA 1VDKA 1I50A 1ZYMA 1XMDA 1U15A 1EZAA 2PFMA 1GK3A 1HY1A 4A15A 4QIWA 3GTDA 4APBA 3LR6A 4NSLA 2PTRA 3GTOA 2F5JA 2E2HA 2B63A 1TJ7A 2JA5A 2O7DA 4FBSA 1YFMA 3BHGA 1TWFA 3UNVA 1K62A 2BE5D 2RJRA 2CW0D 4CEIA 2MQAA 1U16A 4C2MA 2N1DB 2QVEA 1J3UA 2LKMB 3CRVA 4C5SA 1T6PA 1EZBA 1XL7A 1YFEA 5EYTA 1ZYRD 3GTPA 1RE5A 2N3EA 2X75A 1AUWA 1SFOA 1B8FA 4V2QA 4ADMA 3CRW1 2LPJA 1Y2MA 1XLYA 2O7BA 1SMYD 1YNJD 4CEJA 3OCFA 3GTQA 2HWGA 2FIOA 2EZBA 2NYNA 4EFCA 1YNND 2X0OA 2AQLA 2A69D 2E9FA 2X0PA 3RRPA 4APAA 5M0IA 2X0QA 4BABA 3R6QA 2MX8A 1T6JA 2YIIA 4V2RA 2VUMA 3CZOA 4C6GA 4C5RA 1Y1WA 3GZHA 4FLCA 2LTHA 4FFXA 1FUOA 2O78A 5HW2A 2VL7A 2NVXA 1WCMA 2R92A 1XL8A 1YISA 2O6YA 2PTQA 2FELA 2JA7A 2R93A 3NO9A 4HGVA 3TV2A 1Q5NA 1HY0A 4C5UA 2NVYA 3EZAA 1I3QA 2FUSA 1GKJA 2EZAA 1FUPA 1XWOA 3NZ4A 5D6BA 1KQ7A 2A6HD 2JA6A 5EYVA 3GTJA 4BAAA 3KDZA 3E04A 2Y0NA 1TWHA 4EEIA 2E2IA 3R6VA 3GTKA 1TWGA 2OHYA 2HVGA 3EZBA 2VD6A 1DOFA 3FKIA 1I6VD 1JSWA 1DCNA 1TWCA 1TJUA 2O7FA 2LPIA 2HROA 3R6YA 4CQ5A 2QGAB 1HQMD 1C3UA 5IZ2A 1GKMA 2EZCA 3LR8A 1XMCA 2RJSA 3U4QA
chains in the Genus database with same CATH topology
1I0AA 3RD8A 1FURA 1EB4A 3OCEA 1TJWA 3C8TA 3KDYA 2J91A 4MX2A 4NLEA 2PTSA 1TJVA 3QBPA 1GK2A 5F91A 5F92A 1W27A 1C3CA 2O7EA 4ADLA 2NYFA 1K7WA 1FUQA 1VDKA 1U15A 2PFMA 1GK3A 1HY1A 3GTDA 4APBA 4NSLA 2PTRA 1TJ7A 2O7DA 1YFMA 3BHGA 3UNVA 1K62A 2RJRA 1U16A 2QVEA 1J3UA 4C5SA 1T6PA 1YFEA 5EYTA 1RE5A 2X75A 1AUWA 1B8FA 4V2QA 4ADMA 1Y2MA 2O7BA 3OCFA 4EFCA 2NYNA 2E9FA 3RRPA 4APAA 4BABA 3R6QA 2YIIA 1T6JA 3CZOA 4V2RA 4C6GA 4C5RA 4FLCA 3GZHA 4FFXA 1FUOA 2O78A 5HW2A 1YISA 2O6YA 2PTQA 4HGVA 3NO9A 3TV2A 1Q5NA 1HY0A 4C5UA 2FUSA 1GKJA 1XWOA 1FUPA 3NZ4A 5D6BA 1KQ7A 5EYVA 4BAAA 3KDZA 3E04A 4EEIA 3R6VA 2OHYA 2HVGA 2VD6A 1DOFA 2O7FA 1JSWA 1DCNA 1TJUA 3R6YA 4CQ5A 2QGAB 1C3UA 1GKMA 2RJSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I0A A;  3RD8 A;  1FUR A;  1EB4 A;  3OCE A;  1TJW A;  3C8T A;  3KDY A;  2J91 A;  4MX2 A;  4NLE A;  2PTS A;  1TJV A;  3QBP A;  1GK2 A;  5F91 A;  5F92 A;  1W27 A;  1C3C A;  2O7E A;  4ADL A;  2NYF A;  1K7W A;  1FUQ A;  1VDK A;  1U15 A;  2PFM A;  1GK3 A;  1HY1 A;  3GTD A;  4APB A;  4NSL A;  2PTR A;  1TJ7 A;  2O7D A;  1YFM A;  3BHG A;  3UNV A;  1K62 A;  2RJR A;  1U16 A;  2QVE A;  1J3U A;  4C5S A;  1T6P A;  1YFE A;  5EYT A;  1RE5 A;  2X75 A;  1AUW A;  1B8F A;  4V2Q A;  4ADM A;  1Y2M A;  2O7B A;  3OCF A;  4EFC A;  2NYN A;  2E9F A;  3RRP A;  4APA A;  4BAB A;  3R6Q A;  2YII A;  1T6J A;  3CZO A;  4V2R A;  4C6G A;  4C5R A;  4FLC A;  3GZH A;  4FFX A;  1FUO A;  2O78 A;  5HW2 A;  1YIS A;  2O6Y A;  2PTQ A;  4HGV A;  3NO9 A;  3TV2 A;  1Q5N A;  1HY0 A;  4C5U A;  2FUS A;  1GKJ A;  1XWO A;  1FUP A;  3NZ4 A;  5D6B A;  1KQ7 A;  5EYV A;  4BAA A;  3KDZ A;  3E04 A;  4EEI A;  3R6V A;  2OHY A;  2HVG A;  2VD6 A;  1DOF A;  2O7F A;  1JSW A;  1DCN A;  1TJU A;  3R6Y A;  4CQ5 A;  2QGA B;  1C3U A;  1GKM A;  2RJS A; 
#chains in the Genus database with same CATH topology
 4CEH A;  2FEN A;  3GTL A;  2FIP A;  2VK9 A;  2YU9 A;  2R7Z A;  2MX9 A;  3GTG A;  1I0A A;  3RD8 A;  2MP0 A;  5H8W A;  2VSF A;  1FUR A;  3H0G A;  1EB4 A;  2A68 D;  3OCE A;  4WNL A;  2LYI A;  3CQZ A;  1TJW A;  1Y1V A;  3C8T A;  3KDY A;  2J91 A;  3LRD A;  1IW7 D;  2A6E D;  2K3O A;  2PTS A;  4MX2 A;  4NLE A;  2O5J D;  3LR2 A;  1TJV A;  3QBP A;  1K83 A;  2K3Q A;  1GK2 A;  5F91 A;  2K3N A;  5F92 A;  1W27 A;  3GTM A;  3EZE A;  3U44 A;  1C3C A;  2O7E A;  1R9T A;  4ADL A;  1TWA A;  2NYF A;  5M0J A;  1K7W A;  1FUQ A;  1VDK A;  1I50 A;  1ZYM A;  1XMD A;  1U15 A;  1EZA A;  2PFM A;  1GK3 A;  1HY1 A;  4A15 A;  4QIW A;  3GTD A;  4APB A;  3LR6 A;  4NSL A;  2PTR A;  3GTO A;  2F5J A;  2E2H A;  2B63 A;  1TJ7 A;  2JA5 A;  2O7D A;  4FBS A;  1YFM A;  3BHG A;  1TWF A;  3UNV A;  1K62 A;  2BE5 D;  2RJR A;  2CW0 D;  4CEI A;  2MQA A;  1U16 A;  4C2M A;  2N1D B;  2QVE A;  1J3U A;  2LKM B;  3CRV A;  4C5S A;  1T6P A;  1EZB A;  1XL7 A;  1YFE A;  5EYT A;  1ZYR D;  3GTP A;  1RE5 A;  2N3E A;  2X75 A;  1AUW A;  1SFO A;  1B8F A;  4V2Q A;  4ADM A;  3CRW 1;  2LPJ A;  1Y2M A;  1XLY A;  2O7B A;  1SMY D;  1YNJ D;  4CEJ A;  3OCF A;  3GTQ A;  2HWG A;  2FIO A;  2EZB A;  2NYN A;  4EFC A;  1YNN D;  2X0O A;  2AQL A;  2A69 D;  2E9F A;  2X0P A;  3RRP A;  4APA A;  5M0I A;  2X0Q A;  4BAB A;  3R6Q A;  2MX8 A;  1T6J A;  2YII A;  4V2R A;  2VUM A;  3CZO A;  4C6G A;  4C5R A;  1Y1W A;  3GZH A;  4FLC A;  2LTH A;  4FFX A;  1FUO A;  2O78 A;  5HW2 A;  2VL7 A;  2NVX A;  1WCM A;  2R92 A;  1XL8 A;  1YIS A;  2O6Y A;  2PTQ A;  2FEL A;  2JA7 A;  2R93 A;  3NO9 A;  4HGV A;  3TV2 A;  1Q5N A;  1HY0 A;  4C5U A;  2NVY A;  3EZA A;  1I3Q A;  2FUS A;  1GKJ A;  2EZA A;  1FUP A;  1XWO A;  3NZ4 A;  5D6B A;  1KQ7 A;  2A6H D;  2JA6 A;  5EYV A;  3GTJ A;  4BAA A;  3KDZ A;  3E04 A;  2Y0N A;  1TWH A;  4EEI A;  2E2I A;  3R6V A;  3GTK A;  1TWG A;  2OHY A;  2HVG A;  3EZB A;  2VD6 A;  1DOF A;  3FKI A;  1I6V D;  1JSW A;  1DCN A;  1TWC A;  1TJU A;  2O7F A;  2LPI A;  2HRO A;  3R6Y A;  4CQ5 A;  2QGA B;  1HQM D;  1C3U A;  5IZ2 A;  1GKM A;  2EZC A;  3LR8 A;  1XMC A;  2RJS A;  3U4Q A; 
#chains in the Genus database with same CATH homology
 1I0A A;  3RD8 A;  1FUR A;  1EB4 A;  3OCE A;  1TJW A;  3C8T A;  3KDY A;  2J91 A;  4MX2 A;  4NLE A;  2PTS A;  1TJV A;  3QBP A;  1GK2 A;  5F91 A;  5F92 A;  1W27 A;  1C3C A;  2O7E A;  4ADL A;  2NYF A;  1K7W A;  1FUQ A;  1VDK A;  1U15 A;  2PFM A;  1GK3 A;  1HY1 A;  3GTD A;  4APB A;  4NSL A;  2PTR A;  1TJ7 A;  2O7D A;  1YFM A;  3BHG A;  3UNV A;  1K62 A;  2RJR A;  1U16 A;  2QVE A;  1J3U A;  4C5S A;  1T6P A;  1YFE A;  5EYT A;  1RE5 A;  2X75 A;  1AUW A;  1B8F A;  4V2Q A;  4ADM A;  1Y2M A;  2O7B A;  3OCF A;  4EFC A;  2NYN A;  2E9F A;  3RRP A;  4APA A;  4BAB A;  3R6Q A;  2YII A;  1T6J A;  3CZO A;  4V2R A;  4C6G A;  4C5R A;  4FLC A;  3GZH A;  4FFX A;  1FUO A;  2O78 A;  5HW2 A;  1YIS A;  2O6Y A;  2PTQ A;  4HGV A;  3NO9 A;  3TV2 A;  1Q5N A;  1HY0 A;  4C5U A;  2FUS A;  1GKJ A;  1XWO A;  1FUP A;  3NZ4 A;  5D6B A;  1KQ7 A;  5EYV A;  4BAA A;  3KDZ A;  3E04 A;  4EEI A;  3R6V A;  2OHY A;  2HVG A;  2VD6 A;  1DOF A;  2O7F A;  1JSW A;  1DCN A;  1TJU A;  3R6Y A;  4CQ5 A;  2QGA B;  1C3U A;  1GKM A;  2RJS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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