4C6GA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 252
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
252
sequence length
669
structure length
624
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEACRARVETCSSWVQRKAEDGADIYGLQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSASGDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVAGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHTDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
molecule tags Lyase
source organism Taxus wallichiana var. chinensis
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 252
structure length 624
sequence length 669
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c6gA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c6gA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c6gA02
3R6VA 3R6YA 2O78A 1XWOA 1DCNA 2O6YA 3RRPA 2HVGA 1J3UA 4CQ5A 5HW2A 2NYFA 1GK2A 2OHYA 3CZOA 1Y2MA 2RJRA 2J91A 3C8TA 2PTSA 4BAAA 1TJUA 1GKMA 2FUSA 1Q5NA 1GK3A 1U16A 4NLEA 1B8FA 3GTDA 3BHGA 2QGAB 3OCFA 2VD6A 4APAA 1FURA 2PTRA 4V2RA 1FUQA 4NSLA 1GKJA 4APBA 4C5UA 1KQ7A 3GZHA 4MX2A 1DOFA 2O7DA 2O7EA 1YFMA 2O7BA 5F92A 1K62A 4EEIA 1TJVA 2E9FA 1K7WA 1EB4A 3TV2A 1VDKA 1YISA 2RJSA 3NZ4A 4FLCA 4V2QA 4C6GA 2X75A 2NYNA 5EYVA 5EYTA 1T6JA 1YFEA 2QVEA 4FFXA 4BABA 3NO9A 2PFMA 3KDYA 4ADMA 2PTQA 1RE5A 1C3UA 1HY1A 1I0AA 3E04A 3QBPA 5D6BA 1JSWA 1W27A 5F91A 1FUOA 1C3CA 1FUPA 3UNVA 1TJ7A 4C5SA 1TJWA 4EFCA 1HY0A 3RD8A 1T6PA 2O7FA 4C5RA 3KDZA 4HGVA 3R6QA 2YIIA 1AUWA 4ADLA 3OCEA 1U15A
chains in the Genus database with same CATH superfamily
2EZCA 2A6HD 3R6VA 3R6YA 2O78A 1XWOA 1DCNA 2O6YA 3RRPA 2E2HA 3EZEA 4CEJA 2HVGA 3GTQA 2VUMA 4CQ5A 1J3UA 5HW2A 3CRW1 1IW7D 2MP0A 2LPIA 2R7ZA 2NYFA 1YNND 4CEHA 1I6VD 4FBSA 1Y1WA 2X0PA 2NVXA 1TWHA 2FENA 1GK2A 4WNLA 2OHYA 3CZOA 1Y2MA 2RJRA 2J91A 2MX8A 1K83A 3C8TA 3CQZA 2PTSA 2FELA 4BAAA 1TJUA 1XL7A 2A68D 2VK9A 1ZYMA 2NVYA 1GKMA 1I3QA 2LYIA 4A15A 2EZAA 2R93A 2FUSA 2X0OA 1Q5NA 3LR8A 1GK3A 1R9TA 2BE5D 2JA6A 2X0QA 1U16A 4NLEA 4CEIA 1B8FA 2N1DB 3BHGA 3GTDA 2QGAB 3LR6A 3OCFA 2VD6A 2K3NA 3EZBA 5M0IA 4APAA 1FURA 3LR2A 2PTRA 4V2RA 1TWGA 1FUQA 4NSLA 2HWGA 1GKJA 4APBA 3EZAA 1SMYD 4C5UA 1KQ7A 2JA5A 3GZHA 4MX2A 1DOFA 1TWFA 2A6ED 1I50A 2O7DA 2O7EA 1YNJD 3GTKA 5H8WA 5IZ2A 3GTLA 2A69D 1YFMA 3GTGA 2O7BA 5F92A 1TWCA 1K62A 1TJVA 3GTJA 1K7WA 2E9FA 1XMCA 4EEIA 1EB4A 2F5JA 1TWAA 3TV2A 1EZAA 1VDKA 3U44A 1YISA 2RJSA 3NZ4A 2R92A 4FLCA 2K3QA 4V2QA 2MX9A 4C6GA 1ZYRD 2X75A 2LPJA 1XLYA 2O5JD 5M0JA 3FKIA 2FIPA 2NYNA 2CW0D 2B63A 5EYVA 1WCMA 5EYTA 3CRVA 1T6JA 1YFEA 2VSFA 2QVEA 4QIWA 4FFXA 4BABA 3GTOA 2JA7A 2PFMA 3NO9A 3LRDA 3KDYA 4ADMA 2PTQA 1RE5A 1C3UA 1EZBA 2Y0NA 1HY1A 2FIOA 1XL8A 2LTHA 3U4QA 1SFOA 2N3EA 1I0AA 3E04A 2HROA 2EZBA 3QBPA 2E2IA 5D6BA 1JSWA 1W27A 1Y1VA 2MQAA 4C2MA 1FUOA 5F91A 1C3CA 1FUPA 3UNVA 2K3OA 1TJ7A 4C5SA 1TJWA 2YU9A 4EFCA 1HY0A 3RD8A 1T6PA 3GTPA 2O7FA 1HQMD 4C5RA 2AQLA 3KDZA 4HGVA 2VL7A 3GTMA 2LKMB 3R6QA 2YIIA 1AUWA 4ADLA 1XMDA 3H0GA 3OCEA 1U15A
chains in the Genus database with same CATH topology
3R6VA 3R6YA 2O78A 1XWOA 1DCNA 2O6YA 3RRPA 2HVGA 1J3UA 4CQ5A 5HW2A 2NYFA 1GK2A 2OHYA 3CZOA 1Y2MA 2RJRA 2J91A 3C8TA 2PTSA 4BAAA 1TJUA 1GKMA 2FUSA 1Q5NA 1GK3A 1U16A 4NLEA 1B8FA 3GTDA 3BHGA 2QGAB 3OCFA 2VD6A 4APAA 1FURA 2PTRA 4V2RA 1FUQA 4NSLA 1GKJA 4APBA 4C5UA 1KQ7A 3GZHA 4MX2A 1DOFA 2O7DA 2O7EA 1YFMA 2O7BA 5F92A 1K62A 4EEIA 1TJVA 2E9FA 1K7WA 1EB4A 3TV2A 1VDKA 1YISA 2RJSA 3NZ4A 4FLCA 4V2QA 4C6GA 2X75A 2NYNA 5EYVA 5EYTA 1T6JA 1YFEA 2QVEA 4FFXA 4BABA 3NO9A 2PFMA 3KDYA 4ADMA 2PTQA 1RE5A 1C3UA 1HY1A 1I0AA 3E04A 3QBPA 5D6BA 1JSWA 1W27A 5F91A 1FUOA 1C3CA 1FUPA 3UNVA 1TJ7A 4C5SA 1TJWA 4EFCA 1HY0A 3RD8A 1T6PA 2O7FA 4C5RA 3KDZA 4HGVA 3R6QA 2YIIA 1AUWA 4ADLA 3OCEA 1U15A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3R6V A;  3R6Y A;  2O78 A;  1XWO A;  1DCN A;  2O6Y A;  3RRP A;  2HVG A;  1J3U A;  4CQ5 A;  5HW2 A;  2NYF A;  1GK2 A;  2OHY A;  3CZO A;  1Y2M A;  2RJR A;  2J91 A;  3C8T A;  2PTS A;  4BAA A;  1TJU A;  1GKM A;  2FUS A;  1Q5N A;  1GK3 A;  1U16 A;  4NLE A;  1B8F A;  3GTD A;  3BHG A;  2QGA B;  3OCF A;  2VD6 A;  4APA A;  1FUR A;  2PTR A;  4V2R A;  1FUQ A;  4NSL A;  1GKJ A;  4APB A;  4C5U A;  1KQ7 A;  3GZH A;  4MX2 A;  1DOF A;  2O7D A;  2O7E A;  1YFM A;  2O7B A;  5F92 A;  1K62 A;  4EEI A;  1TJV A;  2E9F A;  1K7W A;  1EB4 A;  3TV2 A;  1VDK A;  1YIS A;  2RJS A;  3NZ4 A;  4FLC A;  4V2Q A;  4C6G A;  2X75 A;  2NYN A;  5EYV A;  5EYT A;  1T6J A;  1YFE A;  2QVE A;  4FFX A;  4BAB A;  3NO9 A;  2PFM A;  3KDY A;  4ADM A;  2PTQ A;  1RE5 A;  1C3U A;  1HY1 A;  1I0A A;  3E04 A;  3QBP A;  5D6B A;  1JSW A;  1W27 A;  5F91 A;  1FUO A;  1C3C A;  1FUP A;  3UNV A;  1TJ7 A;  4C5S A;  1TJW A;  4EFC A;  1HY0 A;  3RD8 A;  1T6P A;  2O7F A;  4C5R A;  3KDZ A;  4HGV A;  3R6Q A;  2YII A;  1AUW A;  4ADL A;  3OCE A;  1U15 A; 
#chains in the Genus database with same CATH topology
 2EZC A;  2A6H D;  3R6V A;  3R6Y A;  2O78 A;  1XWO A;  1DCN A;  2O6Y A;  3RRP A;  2E2H A;  3EZE A;  4CEJ A;  2HVG A;  3GTQ A;  2VUM A;  4CQ5 A;  1J3U A;  5HW2 A;  3CRW 1;  1IW7 D;  2MP0 A;  2LPI A;  2R7Z A;  2NYF A;  1YNN D;  4CEH A;  1I6V D;  4FBS A;  1Y1W A;  2X0P A;  2NVX A;  1TWH A;  2FEN A;  1GK2 A;  4WNL A;  2OHY A;  3CZO A;  1Y2M A;  2RJR A;  2J91 A;  2MX8 A;  1K83 A;  3C8T A;  3CQZ A;  2PTS A;  2FEL A;  4BAA A;  1TJU A;  1XL7 A;  2A68 D;  2VK9 A;  1ZYM A;  2NVY A;  1GKM A;  1I3Q A;  2LYI A;  4A15 A;  2EZA A;  2R93 A;  2FUS A;  2X0O A;  1Q5N A;  3LR8 A;  1GK3 A;  1R9T A;  2BE5 D;  2JA6 A;  2X0Q A;  1U16 A;  4NLE A;  4CEI A;  1B8F A;  2N1D B;  3BHG A;  3GTD A;  2QGA B;  3LR6 A;  3OCF A;  2VD6 A;  2K3N A;  3EZB A;  5M0I A;  4APA A;  1FUR A;  3LR2 A;  2PTR A;  4V2R A;  1TWG A;  1FUQ A;  4NSL A;  2HWG A;  1GKJ A;  4APB A;  3EZA A;  1SMY D;  4C5U A;  1KQ7 A;  2JA5 A;  3GZH A;  4MX2 A;  1DOF A;  1TWF A;  2A6E D;  1I50 A;  2O7D A;  2O7E A;  1YNJ D;  3GTK A;  5H8W A;  5IZ2 A;  3GTL A;  2A69 D;  1YFM A;  3GTG A;  2O7B A;  5F92 A;  1TWC A;  1K62 A;  1TJV A;  3GTJ A;  1K7W A;  2E9F A;  1XMC A;  4EEI A;  1EB4 A;  2F5J A;  1TWA A;  3TV2 A;  1EZA A;  1VDK A;  3U44 A;  1YIS A;  2RJS A;  3NZ4 A;  2R92 A;  4FLC A;  2K3Q A;  4V2Q A;  2MX9 A;  4C6G A;  1ZYR D;  2X75 A;  2LPJ A;  1XLY A;  2O5J D;  5M0J A;  3FKI A;  2FIP A;  2NYN A;  2CW0 D;  2B63 A;  5EYV A;  1WCM A;  5EYT A;  3CRV A;  1T6J A;  1YFE A;  2VSF A;  2QVE A;  4QIW A;  4FFX A;  4BAB A;  3GTO A;  2JA7 A;  2PFM A;  3NO9 A;  3LRD A;  3KDY A;  4ADM A;  2PTQ A;  1RE5 A;  1C3U A;  1EZB A;  2Y0N A;  1HY1 A;  2FIO A;  1XL8 A;  2LTH A;  3U4Q A;  1SFO A;  2N3E A;  1I0A A;  3E04 A;  2HRO A;  2EZB A;  3QBP A;  2E2I A;  5D6B A;  1JSW A;  1W27 A;  1Y1V A;  2MQA A;  4C2M A;  1FUO A;  5F91 A;  1C3C A;  1FUP A;  3UNV A;  2K3O A;  1TJ7 A;  4C5S A;  1TJW A;  2YU9 A;  4EFC A;  1HY0 A;  3RD8 A;  1T6P A;  3GTP A;  2O7F A;  1HQM D;  4C5R A;  2AQL A;  3KDZ A;  4HGV A;  2VL7 A;  3GTM A;  2LKM B;  3R6Q A;  2YII A;  1AUW A;  4ADL A;  1XMD A;  3H0G A;  3OCE A;  1U15 A; 
#chains in the Genus database with same CATH homology
 3R6V A;  3R6Y A;  2O78 A;  1XWO A;  1DCN A;  2O6Y A;  3RRP A;  2HVG A;  1J3U A;  4CQ5 A;  5HW2 A;  2NYF A;  1GK2 A;  2OHY A;  3CZO A;  1Y2M A;  2RJR A;  2J91 A;  3C8T A;  2PTS A;  4BAA A;  1TJU A;  1GKM A;  2FUS A;  1Q5N A;  1GK3 A;  1U16 A;  4NLE A;  1B8F A;  3GTD A;  3BHG A;  2QGA B;  3OCF A;  2VD6 A;  4APA A;  1FUR A;  2PTR A;  4V2R A;  1FUQ A;  4NSL A;  1GKJ A;  4APB A;  4C5U A;  1KQ7 A;  3GZH A;  4MX2 A;  1DOF A;  2O7D A;  2O7E A;  1YFM A;  2O7B A;  5F92 A;  1K62 A;  4EEI A;  1TJV A;  2E9F A;  1K7W A;  1EB4 A;  3TV2 A;  1VDK A;  1YIS A;  2RJS A;  3NZ4 A;  4FLC A;  4V2Q A;  4C6G A;  2X75 A;  2NYN A;  5EYV A;  5EYT A;  1T6J A;  1YFE A;  2QVE A;  4FFX A;  4BAB A;  3NO9 A;  2PFM A;  3KDY A;  4ADM A;  2PTQ A;  1RE5 A;  1C3U A;  1HY1 A;  1I0A A;  3E04 A;  3QBP A;  5D6B A;  1JSW A;  1W27 A;  5F91 A;  1FUO A;  1C3C A;  1FUP A;  3UNV A;  1TJ7 A;  4C5S A;  1TJW A;  4EFC A;  1HY0 A;  3RD8 A;  1T6P A;  2O7F A;  4C5R A;  3KDZ A;  4HGV A;  3R6Q A;  2YII A;  1AUW A;  4ADL A;  3OCE A;  1U15 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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