4C6GA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 252
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
252
sequence length
669
structure length
624
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEACRARVETCSSWVQRKAEDGADIYGLQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSASGDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVAGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHTDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
molecule tags Lyase
source organism Taxus wallichiana var. chinensis
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 252
structure length 624
sequence length 669
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c6gA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c6gA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c6gA02
1FUPA 1GKMA 1C3UA 1VDKA 4EFCA 1HY1A 1YFMA 1DCNA 4V2RA 1FUOA 4EEIA 1YISA 1GK2A 4MX2A 3OCEA 4BABA 1FUQA 5F92A 1K7WA 3TV2A 1U16A 1T6JA 2FUSA 1EB4A 1AUWA 1TJWA 3C8TA 2O7EA 2YIIA 3R6VA 1RE5A 4C5UA 4V2QA 4C5RA 2O78A 3RRPA 4NLEA 1B8FA 3GTDA 1GK3A 1TJVA 4C5SA 1JSWA 1DOFA 4BAAA 3NZ4A 5D6BA 2VD6A 5EYVA 3QBPA 4FFXA 2O7BA 1I0AA 3UNVA 1Q5NA 3E04A 5HW2A 3CZOA 2E9FA 1TJUA 4ADMA 1U15A 1T6PA 2RJRA 1XWOA 1W27A 2PTQA 2J91A 1FURA 1J3UA 2NYFA 2QVEA 5F91A 2PFMA 3RD8A 4APAA 3KDYA 4FLCA 3NO9A 5EYTA 1KQ7A 2RJSA 4CQ5A 2QGAB 2O7DA 4HGVA 1YFEA 4C6GA 1TJ7A 3KDZA 3OCFA 3R6QA 2X75A 4NSLA 1C3CA 4ADLA 1K62A 2O7FA 2PTSA 2OHYA 1HY0A 3GZHA 2PTRA 2HVGA 2O6YA 1GKJA 3R6YA 4APBA 1Y2MA 2NYNA 3BHGA
chains in the Genus database with same CATH superfamily
2YU9A 1FUPA 1GKMA 2HWGA 1C3UA 2A6ED 1XLYA 2MX8A 2LYIA 1VDKA 1IW7D 4EFCA 1HY1A 1YFMA 2EZAA 3GTQA 1DCNA 3GTKA 4V2RA 2X0QA 1EZAA 4CEJA 3GTGA 3EZBA 1FUOA 4EEIA 2LPJA 1ZYMA 1YISA 2F5JA 1EZBA 2VUMA 1GK2A 2E2IA 2JA6A 4MX2A 3OCEA 3LRDA 3EZAA 3LR2A 4BABA 2MP0A 2FELA 2EZCA 3GTOA 1SMYD 1FUQA 1TWGA 5F92A 1K7WA 3TV2A 1U16A 1T6JA 2MX9A 1YNND 1EB4A 2FUSA 1AUWA 4CEIA 1TJWA 3C8TA 4C2MA 1I50A 2O7EA 2YIIA 3R6VA 1RE5A 4C5UA 4V2QA 4C5RA 2O78A 3RRPA 3GTPA 4NLEA 2B63A 1TWHA 1B8FA 2LKMB 2EZBA 4FBSA 1GK3A 3GTDA 2VSFA 3EZEA 1XL8A 1TJVA 1XL7A 4C5SA 3H0GA 1Y1WA 2N1DB 1JSWA 1TWCA 1DOFA 2K3QA 1XMDA 2X0OA 5M0JA 2JA5A 3GTMA 2A68D 4WNLA 2VL7A 4BAAA 1Y1VA 3NZ4A 2R93A 1YNJD 2K3NA 2O5JD 5D6BA 2VD6A 5EYVA 3QBPA 4FFXA 2O7BA 2R92A 1I0AA 3UNVA 2FENA 1Q5NA 3E04A 4QIWA 1TWAA 3U4QA 2FIOA 3CZOA 2E9FA 5HW2A 1TJUA 2VK9A 4ADMA 1U15A 5M0IA 2N3EA 1T6PA 2RJRA 1XWOA 2FIPA 1W27A 2PTQA 2A6HD 2LPIA 1ZYRD 2J91A 1FURA 2LTHA 1J3UA 2NYFA 2QVEA 2NVXA 2CW0D 2BE5D 2NVYA 5F91A 1I6VD 2PFMA 3RD8A 4APAA 3KDYA 4FLCA 3NO9A 2AQLA 1SFOA 1I3QA 5EYTA 1KQ7A 2RJSA 4A15A 4CQ5A 2QGAB 3GTJA 2E2HA 2O7DA 3CQZA 3FKIA 4HGVA 1HQMD 2JA7A 1YFEA 4C6GA 1TJ7A 3KDZA 3OCFA 1TWFA 1R9TA 2X75A 3R6QA 2MQAA 2R7ZA 4NSLA 4CEHA 1C3CA 4ADLA 1K62A 2O7FA 2HROA 2PTSA 2X0PA 1K83A 3GTLA 1HY0A 2OHYA 3GZHA 2PTRA 5IZ2A 2A69D 2HVGA 2O6YA 3U44A 3CRVA 5H8WA 2Y0NA 1GKJA 1XMCA 3R6YA 3LR8A 1WCMA 4APBA 1Y2MA 2K3OA 2NYNA 3LR6A 3BHGA 3CRW1
chains in the Genus database with same CATH topology
1FUPA 1GKMA 1C3UA 1VDKA 4EFCA 1HY1A 1YFMA 1DCNA 4V2RA 1FUOA 4EEIA 1YISA 1GK2A 4MX2A 3OCEA 4BABA 1FUQA 5F92A 1K7WA 3TV2A 1U16A 1T6JA 2FUSA 1EB4A 1AUWA 1TJWA 3C8TA 2O7EA 2YIIA 3R6VA 1RE5A 4C5UA 4V2QA 4C5RA 2O78A 3RRPA 4NLEA 1B8FA 3GTDA 1GK3A 1TJVA 4C5SA 1JSWA 1DOFA 4BAAA 3NZ4A 5D6BA 2VD6A 5EYVA 3QBPA 4FFXA 2O7BA 1I0AA 3UNVA 1Q5NA 3E04A 5HW2A 3CZOA 2E9FA 1TJUA 4ADMA 1U15A 1T6PA 2RJRA 1XWOA 1W27A 2PTQA 2J91A 1FURA 1J3UA 2NYFA 2QVEA 5F91A 2PFMA 3RD8A 4APAA 3KDYA 4FLCA 3NO9A 5EYTA 1KQ7A 2RJSA 4CQ5A 2QGAB 2O7DA 4HGVA 1YFEA 4C6GA 1TJ7A 3KDZA 3OCFA 3R6QA 2X75A 4NSLA 1C3CA 4ADLA 1K62A 2O7FA 2PTSA 2OHYA 1HY0A 3GZHA 2PTRA 2HVGA 2O6YA 1GKJA 3R6YA 4APBA 1Y2MA 2NYNA 3BHGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FUP A;  1GKM A;  1C3U A;  1VDK A;  4EFC A;  1HY1 A;  1YFM A;  1DCN A;  4V2R A;  1FUO A;  4EEI A;  1YIS A;  1GK2 A;  4MX2 A;  3OCE A;  4BAB A;  1FUQ A;  5F92 A;  1K7W A;  3TV2 A;  1U16 A;  1T6J A;  2FUS A;  1EB4 A;  1AUW A;  1TJW A;  3C8T A;  2O7E A;  2YII A;  3R6V A;  1RE5 A;  4C5U A;  4V2Q A;  4C5R A;  2O78 A;  3RRP A;  4NLE A;  1B8F A;  3GTD A;  1GK3 A;  1TJV A;  4C5S A;  1JSW A;  1DOF A;  4BAA A;  3NZ4 A;  5D6B A;  2VD6 A;  5EYV A;  3QBP A;  4FFX A;  2O7B A;  1I0A A;  3UNV A;  1Q5N A;  3E04 A;  5HW2 A;  3CZO A;  2E9F A;  1TJU A;  4ADM A;  1U15 A;  1T6P A;  2RJR A;  1XWO A;  1W27 A;  2PTQ A;  2J91 A;  1FUR A;  1J3U A;  2NYF A;  2QVE A;  5F91 A;  2PFM A;  3RD8 A;  4APA A;  3KDY A;  4FLC A;  3NO9 A;  5EYT A;  1KQ7 A;  2RJS A;  4CQ5 A;  2QGA B;  2O7D A;  4HGV A;  1YFE A;  4C6G A;  1TJ7 A;  3KDZ A;  3OCF A;  3R6Q A;  2X75 A;  4NSL A;  1C3C A;  4ADL A;  1K62 A;  2O7F A;  2PTS A;  2OHY A;  1HY0 A;  3GZH A;  2PTR A;  2HVG A;  2O6Y A;  1GKJ A;  3R6Y A;  4APB A;  1Y2M A;  2NYN A;  3BHG A; 
#chains in the Genus database with same CATH topology
 2YU9 A;  1FUP A;  1GKM A;  2HWG A;  1C3U A;  2A6E D;  1XLY A;  2MX8 A;  2LYI A;  1VDK A;  1IW7 D;  4EFC A;  1HY1 A;  1YFM A;  2EZA A;  3GTQ A;  1DCN A;  3GTK A;  4V2R A;  2X0Q A;  1EZA A;  4CEJ A;  3GTG A;  3EZB A;  1FUO A;  4EEI A;  2LPJ A;  1ZYM A;  1YIS A;  2F5J A;  1EZB A;  2VUM A;  1GK2 A;  2E2I A;  2JA6 A;  4MX2 A;  3OCE A;  3LRD A;  3EZA A;  3LR2 A;  4BAB A;  2MP0 A;  2FEL A;  2EZC A;  3GTO A;  1SMY D;  1FUQ A;  1TWG A;  5F92 A;  1K7W A;  3TV2 A;  1U16 A;  1T6J A;  2MX9 A;  1YNN D;  1EB4 A;  2FUS A;  1AUW A;  4CEI A;  1TJW A;  3C8T A;  4C2M A;  1I50 A;  2O7E A;  2YII A;  3R6V A;  1RE5 A;  4C5U A;  4V2Q A;  4C5R A;  2O78 A;  3RRP A;  3GTP A;  4NLE A;  2B63 A;  1TWH A;  1B8F A;  2LKM B;  2EZB A;  4FBS A;  1GK3 A;  3GTD A;  2VSF A;  3EZE A;  1XL8 A;  1TJV A;  1XL7 A;  4C5S A;  3H0G A;  1Y1W A;  2N1D B;  1JSW A;  1TWC A;  1DOF A;  2K3Q A;  1XMD A;  2X0O A;  5M0J A;  2JA5 A;  3GTM A;  2A68 D;  4WNL A;  2VL7 A;  4BAA A;  1Y1V A;  3NZ4 A;  2R93 A;  1YNJ D;  2K3N A;  2O5J D;  5D6B A;  2VD6 A;  5EYV A;  3QBP A;  4FFX A;  2O7B A;  2R92 A;  1I0A A;  3UNV A;  2FEN A;  1Q5N A;  3E04 A;  4QIW A;  1TWA A;  3U4Q A;  2FIO A;  3CZO A;  2E9F A;  5HW2 A;  1TJU A;  2VK9 A;  4ADM A;  1U15 A;  5M0I A;  2N3E A;  1T6P A;  2RJR A;  1XWO A;  2FIP A;  1W27 A;  2PTQ A;  2A6H D;  2LPI A;  1ZYR D;  2J91 A;  1FUR A;  2LTH A;  1J3U A;  2NYF A;  2QVE A;  2NVX A;  2CW0 D;  2BE5 D;  2NVY A;  5F91 A;  1I6V D;  2PFM A;  3RD8 A;  4APA A;  3KDY A;  4FLC A;  3NO9 A;  2AQL A;  1SFO A;  1I3Q A;  5EYT A;  1KQ7 A;  2RJS A;  4A15 A;  4CQ5 A;  2QGA B;  3GTJ A;  2E2H A;  2O7D A;  3CQZ A;  3FKI A;  4HGV A;  1HQM D;  2JA7 A;  1YFE A;  4C6G A;  1TJ7 A;  3KDZ A;  3OCF A;  1TWF A;  1R9T A;  2X75 A;  3R6Q A;  2MQA A;  2R7Z A;  4NSL A;  4CEH A;  1C3C A;  4ADL A;  1K62 A;  2O7F A;  2HRO A;  2PTS A;  2X0P A;  1K83 A;  3GTL A;  1HY0 A;  2OHY A;  3GZH A;  2PTR A;  5IZ2 A;  2A69 D;  2HVG A;  2O6Y A;  3U44 A;  3CRV A;  5H8W A;  2Y0N A;  1GKJ A;  1XMC A;  3R6Y A;  3LR8 A;  1WCM A;  4APB A;  1Y2M A;  2K3O A;  2NYN A;  3LR6 A;  3BHG A;  3CRW 1; 
#chains in the Genus database with same CATH homology
 1FUP A;  1GKM A;  1C3U A;  1VDK A;  4EFC A;  1HY1 A;  1YFM A;  1DCN A;  4V2R A;  1FUO A;  4EEI A;  1YIS A;  1GK2 A;  4MX2 A;  3OCE A;  4BAB A;  1FUQ A;  5F92 A;  1K7W A;  3TV2 A;  1U16 A;  1T6J A;  2FUS A;  1EB4 A;  1AUW A;  1TJW A;  3C8T A;  2O7E A;  2YII A;  3R6V A;  1RE5 A;  4C5U A;  4V2Q A;  4C5R A;  2O78 A;  3RRP A;  4NLE A;  1B8F A;  3GTD A;  1GK3 A;  1TJV A;  4C5S A;  1JSW A;  1DOF A;  4BAA A;  3NZ4 A;  5D6B A;  2VD6 A;  5EYV A;  3QBP A;  4FFX A;  2O7B A;  1I0A A;  3UNV A;  1Q5N A;  3E04 A;  5HW2 A;  3CZO A;  2E9F A;  1TJU A;  4ADM A;  1U15 A;  1T6P A;  2RJR A;  1XWO A;  1W27 A;  2PTQ A;  2J91 A;  1FUR A;  1J3U A;  2NYF A;  2QVE A;  5F91 A;  2PFM A;  3RD8 A;  4APA A;  3KDY A;  4FLC A;  3NO9 A;  5EYT A;  1KQ7 A;  2RJS A;  4CQ5 A;  2QGA B;  2O7D A;  4HGV A;  1YFE A;  4C6G A;  1TJ7 A;  3KDZ A;  3OCF A;  3R6Q A;  2X75 A;  4NSL A;  1C3C A;  4ADL A;  1K62 A;  2O7F A;  2PTS A;  2OHY A;  1HY0 A;  3GZH A;  2PTR A;  2HVG A;  2O6Y A;  1GKJ A;  3R6Y A;  4APB A;  1Y2M A;  2NYN A;  3BHG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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