4CQ5A

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 268
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
268
sequence length
667
structure length
638
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIAGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTLPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
molecule tags Lyase
source organism Taxus wallichiana var. chinensis
molecule keywords PHENYLALANINE AMINOMUTASE
total genus 268
structure length 638
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2014-02-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4cq5A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4cq5A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4cq5A02
2O7EA 3NO9A 3QBPA 1HY1A 4EEIA 1U16A 4APAA 4BAAA 1C3CA 1JSWA 1TJ7A 1AUWA 4V2QA 1T6PA 4BABA 1GKMA 3NZ4A 2O7DA 1YISA 2VD6A 3R6QA 2O6YA 2J91A 3GZHA 2QGAB 2O7FA 2O7BA 1TJUA 2NYNA 1K62A 5EYTA 1DOFA 2QVEA 3OCEA 1GK3A 1VDKA 1DCNA 5F91A 4C5UA 1EB4A 4APBA 3BHGA 2NYFA 4CQ5A 1FUPA 5HW2A 1XWOA 1FURA 1W27A 1Y2MA 5EYVA 1GK2A 1B8FA 1K7WA 1KQ7A 1C3UA 4C5RA 4EFCA 4FLCA 4ADMA 1TJWA 3C8TA 4MX2A 1FUQA 3TV2A 2PFMA 3R6VA 4C5SA 3KDYA 5D6BA 1GKJA 1YFMA 1YFEA 3R6YA 4V2RA 1HY0A 2HVGA 2OHYA 2PTQA 4HGVA 4NSLA 4FFXA 2O78A 2RJSA 3E04A 3RD8A 1J3UA 1I0AA 4NLEA 4ADLA 1Q5NA 1RE5A 2X75A 2E9FA 1T6JA 2RJRA 2FUSA 3KDZA 1FUOA 2PTRA 3RRPA 3UNVA 5F92A 2YIIA 3CZOA 2PTSA 1U15A 3GTDA 3OCFA 1TJVA 4C6GA
chains in the Genus database with same CATH superfamily
2K3QA 1EZBA 4CEHA 2VUMA 2O7EA 3CRVA 3NO9A 1ZYMA 3QBPA 2A69D 1HY1A 4EEIA 1U16A 3U4QA 2NVYA 4APAA 4BAAA 2EZAA 1C3CA 1JSWA 1TWAA 1YNJD 3GTKA 1XMCA 2LPJA 1TJ7A 4WNLA 1AUWA 4V2QA 2N3EA 1T6PA 4BABA 2E2IA 1GKMA 3NZ4A 2O7DA 1XL7A 1YISA 1YNND 2VD6A 3R6QA 1TWFA 2B63A 2O6YA 1I3QA 2J91A 3GZHA 1TWCA 2FIOA 2O7FA 2QGAB 2O7BA 2N1DB 1TJUA 2NYNA 2FENA 1K62A 5EYTA 1XMDA 1DOFA 1HQMD 2YU9A 2QVEA 2BE5D 1GK3A 2A68D 3OCEA 1VDKA 1DCNA 5F91A 4C5UA 1EB4A 3GTLA 4APBA 2K3NA 4QIWA 4CEJA 3BHGA 3GTOA 1Y1WA 2NYFA 5M0JA 4CQ5A 1IW7D 1FUPA 3GTGA 2VSFA 5HW2A 1XLYA 3LRDA 1R9TA 1XWOA 1FURA 1W27A 2HROA 1Y2MA 2R7ZA 2VK9A 5EYVA 1GK2A 4FBSA 1B8FA 3LR6A 2O5JD 1K7WA 1KQ7A 2EZCA 1C3UA 4C5RA 4EFCA 2LKMB 4FLCA 2R93A 4ADMA 2LPIA 1XL8A 3EZAA 2A6ED 1TJWA 3C8TA 4MX2A 1FUQA 3GTMA 3TV2A 2PFMA 3R6VA 1ZYRD 2CW0D 4C5SA 1SFOA 3KDYA 4A15A 5D6BA 4C2MA 2MQAA 1GKJA 2X0QA 2LTHA 1YFMA 3H0GA 1YFEA 3CRW1 1TWGA 2MX9A 2VL7A 3R6YA 2MP0A 4V2RA 2F5JA 1HY0A 3GTJA 2JA6A 2HVGA 2OHYA 1EZAA 2PTQA 2AQLA 3CQZA 4HGVA 4NSLA 2FELA 4FFXA 1TWHA 2E2HA 2O78A 2RJSA 3E04A 5H8WA 3RD8A 3FKIA 1J3UA 3LR2A 2X0PA 1I50A 1I0AA 4NLEA 4ADLA 1WCMA 2Y0NA 3LR8A 1Q5NA 1I6VD 3U44A 2FIPA 2HWGA 2NVXA 1RE5A 2LYIA 2JA7A 1SMYD 2E9FA 3GTQA 2X75A 1T6JA 2RJRA 5M0IA 2JA5A 3EZBA 2FUSA 3KDZA 1FUOA 2MX8A 2PTRA 2EZBA 3GTPA 2A6HD 1K83A 3RRPA 5IZ2A 3UNVA 5F92A 1Y1VA 2YIIA 4CEIA 3CZOA 2PTSA 1U15A 2X0OA 2K3OA 2R92A 3GTDA 3OCFA 3EZEA 1TJVA 4C6GA
chains in the Genus database with same CATH topology
2O7EA 3NO9A 3QBPA 1HY1A 4EEIA 1U16A 4APAA 4BAAA 1C3CA 1JSWA 1TJ7A 1AUWA 4V2QA 1T6PA 4BABA 1GKMA 3NZ4A 2O7DA 1YISA 2VD6A 3R6QA 2O6YA 2J91A 3GZHA 2QGAB 2O7FA 2O7BA 1TJUA 2NYNA 1K62A 5EYTA 1DOFA 2QVEA 3OCEA 1GK3A 1VDKA 1DCNA 5F91A 4C5UA 1EB4A 4APBA 3BHGA 2NYFA 4CQ5A 1FUPA 5HW2A 1XWOA 1FURA 1W27A 1Y2MA 5EYVA 1GK2A 1B8FA 1K7WA 1KQ7A 1C3UA 4C5RA 4EFCA 4FLCA 4ADMA 1TJWA 3C8TA 4MX2A 1FUQA 3TV2A 2PFMA 3R6VA 4C5SA 3KDYA 5D6BA 1GKJA 1YFMA 1YFEA 3R6YA 4V2RA 1HY0A 2HVGA 2OHYA 2PTQA 4HGVA 4NSLA 4FFXA 2O78A 2RJSA 3E04A 3RD8A 1J3UA 1I0AA 4NLEA 4ADLA 1Q5NA 1RE5A 2X75A 2E9FA 1T6JA 2RJRA 2FUSA 3KDZA 1FUOA 2PTRA 3RRPA 3UNVA 5F92A 2YIIA 3CZOA 2PTSA 1U15A 3GTDA 3OCFA 1TJVA 4C6GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O7E A;  3NO9 A;  3QBP A;  1HY1 A;  4EEI A;  1U16 A;  4APA A;  4BAA A;  1C3C A;  1JSW A;  1TJ7 A;  1AUW A;  4V2Q A;  1T6P A;  4BAB A;  1GKM A;  3NZ4 A;  2O7D A;  1YIS A;  2VD6 A;  3R6Q A;  2O6Y A;  2J91 A;  3GZH A;  2QGA B;  2O7F A;  2O7B A;  1TJU A;  2NYN A;  1K62 A;  5EYT A;  1DOF A;  2QVE A;  3OCE A;  1GK3 A;  1VDK A;  1DCN A;  5F91 A;  4C5U A;  1EB4 A;  4APB A;  3BHG A;  2NYF A;  4CQ5 A;  1FUP A;  5HW2 A;  1XWO A;  1FUR A;  1W27 A;  1Y2M A;  5EYV A;  1GK2 A;  1B8F A;  1K7W A;  1KQ7 A;  1C3U A;  4C5R A;  4EFC A;  4FLC A;  4ADM A;  1TJW A;  3C8T A;  4MX2 A;  1FUQ A;  3TV2 A;  2PFM A;  3R6V A;  4C5S A;  3KDY A;  5D6B A;  1GKJ A;  1YFM A;  1YFE A;  3R6Y A;  4V2R A;  1HY0 A;  2HVG A;  2OHY A;  2PTQ A;  4HGV A;  4NSL A;  4FFX A;  2O78 A;  2RJS A;  3E04 A;  3RD8 A;  1J3U A;  1I0A A;  4NLE A;  4ADL A;  1Q5N A;  1RE5 A;  2X75 A;  2E9F A;  1T6J A;  2RJR A;  2FUS A;  3KDZ A;  1FUO A;  2PTR A;  3RRP A;  3UNV A;  5F92 A;  2YII A;  3CZO A;  2PTS A;  1U15 A;  3GTD A;  3OCF A;  1TJV A;  4C6G A; 
#chains in the Genus database with same CATH topology
 2K3Q A;  1EZB A;  4CEH A;  2VUM A;  2O7E A;  3CRV A;  3NO9 A;  1ZYM A;  3QBP A;  2A69 D;  1HY1 A;  4EEI A;  1U16 A;  3U4Q A;  2NVY A;  4APA A;  4BAA A;  2EZA A;  1C3C A;  1JSW A;  1TWA A;  1YNJ D;  3GTK A;  1XMC A;  2LPJ A;  1TJ7 A;  4WNL A;  1AUW A;  4V2Q A;  2N3E A;  1T6P A;  4BAB A;  2E2I A;  1GKM A;  3NZ4 A;  2O7D A;  1XL7 A;  1YIS A;  1YNN D;  2VD6 A;  3R6Q A;  1TWF A;  2B63 A;  2O6Y A;  1I3Q A;  2J91 A;  3GZH A;  1TWC A;  2FIO A;  2O7F A;  2QGA B;  2O7B A;  2N1D B;  1TJU A;  2NYN A;  2FEN A;  1K62 A;  5EYT A;  1XMD A;  1DOF A;  1HQM D;  2YU9 A;  2QVE A;  2BE5 D;  1GK3 A;  2A68 D;  3OCE A;  1VDK A;  1DCN A;  5F91 A;  4C5U A;  1EB4 A;  3GTL A;  4APB A;  2K3N A;  4QIW A;  4CEJ A;  3BHG A;  3GTO A;  1Y1W A;  2NYF A;  5M0J A;  4CQ5 A;  1IW7 D;  1FUP A;  3GTG A;  2VSF A;  5HW2 A;  1XLY A;  3LRD A;  1R9T A;  1XWO A;  1FUR A;  1W27 A;  2HRO A;  1Y2M A;  2R7Z A;  2VK9 A;  5EYV A;  1GK2 A;  4FBS A;  1B8F A;  3LR6 A;  2O5J D;  1K7W A;  1KQ7 A;  2EZC A;  1C3U A;  4C5R A;  4EFC A;  2LKM B;  4FLC A;  2R93 A;  4ADM A;  2LPI A;  1XL8 A;  3EZA A;  2A6E D;  1TJW A;  3C8T A;  4MX2 A;  1FUQ A;  3GTM A;  3TV2 A;  2PFM A;  3R6V A;  1ZYR D;  2CW0 D;  4C5S A;  1SFO A;  3KDY A;  4A15 A;  5D6B A;  4C2M A;  2MQA A;  1GKJ A;  2X0Q A;  2LTH A;  1YFM A;  3H0G A;  1YFE A;  3CRW 1;  1TWG A;  2MX9 A;  2VL7 A;  3R6Y A;  2MP0 A;  4V2R A;  2F5J A;  1HY0 A;  3GTJ A;  2JA6 A;  2HVG A;  2OHY A;  1EZA A;  2PTQ A;  2AQL A;  3CQZ A;  4HGV A;  4NSL A;  2FEL A;  4FFX A;  1TWH A;  2E2H A;  2O78 A;  2RJS A;  3E04 A;  5H8W A;  3RD8 A;  3FKI A;  1J3U A;  3LR2 A;  2X0P A;  1I50 A;  1I0A A;  4NLE A;  4ADL A;  1WCM A;  2Y0N A;  3LR8 A;  1Q5N A;  1I6V D;  3U44 A;  2FIP A;  2HWG A;  2NVX A;  1RE5 A;  2LYI A;  2JA7 A;  1SMY D;  2E9F A;  3GTQ A;  2X75 A;  1T6J A;  2RJR A;  5M0I A;  2JA5 A;  3EZB A;  2FUS A;  3KDZ A;  1FUO A;  2MX8 A;  2PTR A;  2EZB A;  3GTP A;  2A6H D;  1K83 A;  3RRP A;  5IZ2 A;  3UNV A;  5F92 A;  1Y1V A;  2YII A;  4CEI A;  3CZO A;  2PTS A;  1U15 A;  2X0O A;  2K3O A;  2R92 A;  3GTD A;  3OCF A;  3EZE A;  1TJV A;  4C6G A; 
#chains in the Genus database with same CATH homology
 2O7E A;  3NO9 A;  3QBP A;  1HY1 A;  4EEI A;  1U16 A;  4APA A;  4BAA A;  1C3C A;  1JSW A;  1TJ7 A;  1AUW A;  4V2Q A;  1T6P A;  4BAB A;  1GKM A;  3NZ4 A;  2O7D A;  1YIS A;  2VD6 A;  3R6Q A;  2O6Y A;  2J91 A;  3GZH A;  2QGA B;  2O7F A;  2O7B A;  1TJU A;  2NYN A;  1K62 A;  5EYT A;  1DOF A;  2QVE A;  3OCE A;  1GK3 A;  1VDK A;  1DCN A;  5F91 A;  4C5U A;  1EB4 A;  4APB A;  3BHG A;  2NYF A;  4CQ5 A;  1FUP A;  5HW2 A;  1XWO A;  1FUR A;  1W27 A;  1Y2M A;  5EYV A;  1GK2 A;  1B8F A;  1K7W A;  1KQ7 A;  1C3U A;  4C5R A;  4EFC A;  4FLC A;  4ADM A;  1TJW A;  3C8T A;  4MX2 A;  1FUQ A;  3TV2 A;  2PFM A;  3R6V A;  4C5S A;  3KDY A;  5D6B A;  1GKJ A;  1YFM A;  1YFE A;  3R6Y A;  4V2R A;  1HY0 A;  2HVG A;  2OHY A;  2PTQ A;  4HGV A;  4NSL A;  4FFX A;  2O78 A;  2RJS A;  3E04 A;  3RD8 A;  1J3U A;  1I0A A;  4NLE A;  4ADL A;  1Q5N A;  1RE5 A;  2X75 A;  2E9F A;  1T6J A;  2RJR A;  2FUS A;  3KDZ A;  1FUO A;  2PTR A;  3RRP A;  3UNV A;  5F92 A;  2YII A;  3CZO A;  2PTS A;  1U15 A;  3GTD A;  3OCF A;  1TJV A;  4C6G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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