4CQ5A

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 268
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
268
sequence length
667
structure length
638
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIAGVTTGFGACSSRRTNRLSELQESLIRCLLAGVFTLPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
molecule tags Lyase
source organism Taxus wallichiana var. chinensis
molecule keywords PHENYLALANINE AMINOMUTASE
total genus 268
structure length 638
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2014-02-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4cq5A03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4cq5A01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4cq5A02
1TJWA 1J3UA 1I0AA 3C8TA 4C6GA 1FUOA 1T6PA 2QGAB 1HY1A 2O78A 1TJUA 1GK2A 5EYVA 4BABA 1FURA 4EEIA 1GKJA 2NYFA 2YIIA 1TJVA 1TJ7A 5F92A 3KDZA 2HVGA 4C5SA 4C5UA 4V2QA 3GZHA 1GK3A 1FUQA 3BHGA 1XWOA 2FUSA 2VD6A 4APAA 3OCFA 3GTDA 4BAAA 1FUPA 1JSWA 2E9FA 1EB4A 4C5RA 3R6VA 4ADMA 3E04A 2X75A 1HY0A 1DCNA 4FLCA 2O7DA 1Y2MA 4FFXA 1U16A 3QBPA 2O7EA 2PFMA 5HW2A 1C3CA 5F91A 3R6QA 3KDYA 1W27A 4CQ5A 2PTRA 1YISA 2RJRA 4APBA 1T6JA 5EYTA 1KQ7A 4MX2A 2J91A 1U15A 1B8FA 2O6YA 2QVEA 1K7WA 3R6YA 3CZOA 1YFEA 1K62A 1Q5NA 3NZ4A 1DOFA 3TV2A 2O7FA 1VDKA 2PTSA 1C3UA 3NO9A 4NSLA 3OCEA 4ADLA 1RE5A 2OHYA 4HGVA 1GKMA 2O7BA 1YFMA 2NYNA 4EFCA 4V2RA 2RJSA 4NLEA 5D6BA 2PTQA 1AUWA 3UNVA 3RRPA 3RD8A
chains in the Genus database with same CATH superfamily
2N3EA 1TJWA 3EZBA 1J3UA 2K3QA 1I0AA 2MX9A 5M0JA 1XMDA 4C2MA 3LR8A 1R9TA 2VK9A 1YNND 3C8TA 4C6GA 1FUOA 1T6PA 2QGAB 1Y1VA 1HY1A 2A6HD 2O78A 3GTJA 1TJUA 1TWFA 1YNJD 3FKIA 1GK2A 2YU9A 5EYVA 4BABA 1FURA 2R92A 4EEIA 3GTGA 2R7ZA 2N1DB 1EZBA 1TWCA 1GKJA 1IW7D 2NYFA 2YIIA 1TJVA 1TJ7A 2NVXA 5F92A 3KDZA 2JA5A 4C5SA 3GTMA 2AQLA 4C5UA 2BE5D 2HVGA 4V2QA 3GZHA 2X0OA 2O5JD 1GK3A 1FUQA 1TWAA 3BHGA 1XWOA 2FUSA 5IZ2A 1ZYMA 4CEJA 2FENA 2VD6A 4APAA 2LTHA 3OCFA 3GTDA 4BAAA 1FUPA 1JSWA 2E9FA 1EB4A 1SFOA 4WNLA 3CRVA 4C5RA 3R6VA 2Y0NA 3LR2A 4CEIA 3E04A 4ADMA 4QIWA 2FELA 2X75A 2LPJA 1HY0A 1HQMD 3GTOA 1DCNA 2LPIA 4FLCA 1XLYA 1Y2MA 3LRDA 2O7DA 4FFXA 2CW0D 1U16A 1K83A 2E2HA 3QBPA 1EZAA 2E2IA 2O7EA 2MP0A 2NVYA 2R93A 2PFMA 5M0IA 4FBSA 1TWHA 2FIOA 1C3CA 5F91A 2EZCA 3R6QA 5HW2A 3KDYA 1XL7A 2F5JA 1Y1WA 1W27A 3LR6A 4CQ5A 2PTRA 2X0QA 1YISA 2K3OA 2RJRA 4APBA 1T6JA 5EYTA 2A6ED 3GTLA 2MX8A 1KQ7A 2J91A 4MX2A 1U15A 2B63A 2EZBA 1B8FA 3EZEA 2JA7A 2O6YA 2QVEA 3U4QA 1K7WA 3R6YA 3H0GA 3CZOA 1YFEA 1K62A 1Q5NA 2MQAA 4CEHA 4A15A 3NZ4A 2HWGA 1DOFA 3TV2A 2HROA 1SMYD 3GTKA 2O7FA 1VDKA 2A69D 2LYIA 2PTSA 1C3UA 1I6VD 2EZAA 2VL7A 3NO9A 4NSLA 5H8WA 3OCEA 2VSFA 2FIPA 1XL8A 1I50A 4ADLA 1RE5A 2OHYA 1ZYRD 3EZAA 3CQZA 2A68D 4HGVA 1GKMA 2O7BA 2X0PA 1YFMA 3GTQA 2NYNA 4EFCA 4V2RA 2RJSA 3GTPA 4NLEA 5D6BA 2VUMA 2PTQA 1TWGA 3U44A 1AUWA 3CRW1 3UNVA 1I3QA 1XMCA 1WCMA 2K3NA 3RD8A 3RRPA 2LKMB 2JA6A
chains in the Genus database with same CATH topology
1TJWA 1J3UA 1I0AA 3C8TA 4C6GA 1FUOA 1T6PA 2QGAB 1HY1A 2O78A 1TJUA 1GK2A 5EYVA 4BABA 1FURA 4EEIA 1GKJA 2NYFA 2YIIA 1TJVA 1TJ7A 5F92A 3KDZA 2HVGA 4C5SA 4C5UA 4V2QA 3GZHA 1GK3A 1FUQA 3BHGA 1XWOA 2FUSA 2VD6A 4APAA 3OCFA 3GTDA 4BAAA 1FUPA 1JSWA 2E9FA 1EB4A 4C5RA 3R6VA 4ADMA 3E04A 2X75A 1HY0A 1DCNA 4FLCA 2O7DA 1Y2MA 4FFXA 1U16A 3QBPA 2O7EA 2PFMA 5HW2A 1C3CA 5F91A 3R6QA 3KDYA 1W27A 4CQ5A 2PTRA 1YISA 2RJRA 4APBA 1T6JA 5EYTA 1KQ7A 4MX2A 2J91A 1U15A 1B8FA 2O6YA 2QVEA 1K7WA 3R6YA 3CZOA 1YFEA 1K62A 1Q5NA 3NZ4A 1DOFA 3TV2A 2O7FA 1VDKA 2PTSA 1C3UA 3NO9A 4NSLA 3OCEA 4ADLA 1RE5A 2OHYA 4HGVA 1GKMA 2O7BA 1YFMA 2NYNA 4EFCA 4V2RA 2RJSA 4NLEA 5D6BA 2PTQA 1AUWA 3UNVA 3RRPA 3RD8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TJW A;  1J3U A;  1I0A A;  3C8T A;  4C6G A;  1FUO A;  1T6P A;  2QGA B;  1HY1 A;  2O78 A;  1TJU A;  1GK2 A;  5EYV A;  4BAB A;  1FUR A;  4EEI A;  1GKJ A;  2NYF A;  2YII A;  1TJV A;  1TJ7 A;  5F92 A;  3KDZ A;  2HVG A;  4C5S A;  4C5U A;  4V2Q A;  3GZH A;  1GK3 A;  1FUQ A;  3BHG A;  1XWO A;  2FUS A;  2VD6 A;  4APA A;  3OCF A;  3GTD A;  4BAA A;  1FUP A;  1JSW A;  2E9F A;  1EB4 A;  4C5R A;  3R6V A;  4ADM A;  3E04 A;  2X75 A;  1HY0 A;  1DCN A;  4FLC A;  2O7D A;  1Y2M A;  4FFX A;  1U16 A;  3QBP A;  2O7E A;  2PFM A;  5HW2 A;  1C3C A;  5F91 A;  3R6Q A;  3KDY A;  1W27 A;  4CQ5 A;  2PTR A;  1YIS A;  2RJR A;  4APB A;  1T6J A;  5EYT A;  1KQ7 A;  4MX2 A;  2J91 A;  1U15 A;  1B8F A;  2O6Y A;  2QVE A;  1K7W A;  3R6Y A;  3CZO A;  1YFE A;  1K62 A;  1Q5N A;  3NZ4 A;  1DOF A;  3TV2 A;  2O7F A;  1VDK A;  2PTS A;  1C3U A;  3NO9 A;  4NSL A;  3OCE A;  4ADL A;  1RE5 A;  2OHY A;  4HGV A;  1GKM A;  2O7B A;  1YFM A;  2NYN A;  4EFC A;  4V2R A;  2RJS A;  4NLE A;  5D6B A;  2PTQ A;  1AUW A;  3UNV A;  3RRP A;  3RD8 A; 
#chains in the Genus database with same CATH topology
 2N3E A;  1TJW A;  3EZB A;  1J3U A;  2K3Q A;  1I0A A;  2MX9 A;  5M0J A;  1XMD A;  4C2M A;  3LR8 A;  1R9T A;  2VK9 A;  1YNN D;  3C8T A;  4C6G A;  1FUO A;  1T6P A;  2QGA B;  1Y1V A;  1HY1 A;  2A6H D;  2O78 A;  3GTJ A;  1TJU A;  1TWF A;  1YNJ D;  3FKI A;  1GK2 A;  2YU9 A;  5EYV A;  4BAB A;  1FUR A;  2R92 A;  4EEI A;  3GTG A;  2R7Z A;  2N1D B;  1EZB A;  1TWC A;  1GKJ A;  1IW7 D;  2NYF A;  2YII A;  1TJV A;  1TJ7 A;  2NVX A;  5F92 A;  3KDZ A;  2JA5 A;  4C5S A;  3GTM A;  2AQL A;  4C5U A;  2BE5 D;  2HVG A;  4V2Q A;  3GZH A;  2X0O A;  2O5J D;  1GK3 A;  1FUQ A;  1TWA A;  3BHG A;  1XWO A;  2FUS A;  5IZ2 A;  1ZYM A;  4CEJ A;  2FEN A;  2VD6 A;  4APA A;  2LTH A;  3OCF A;  3GTD A;  4BAA A;  1FUP A;  1JSW A;  2E9F A;  1EB4 A;  1SFO A;  4WNL A;  3CRV A;  4C5R A;  3R6V A;  2Y0N A;  3LR2 A;  4CEI A;  3E04 A;  4ADM A;  4QIW A;  2FEL A;  2X75 A;  2LPJ A;  1HY0 A;  1HQM D;  3GTO A;  1DCN A;  2LPI A;  4FLC A;  1XLY A;  1Y2M A;  3LRD A;  2O7D A;  4FFX A;  2CW0 D;  1U16 A;  1K83 A;  2E2H A;  3QBP A;  1EZA A;  2E2I A;  2O7E A;  2MP0 A;  2NVY A;  2R93 A;  2PFM A;  5M0I A;  4FBS A;  1TWH A;  2FIO A;  1C3C A;  5F91 A;  2EZC A;  3R6Q A;  5HW2 A;  3KDY A;  1XL7 A;  2F5J A;  1Y1W A;  1W27 A;  3LR6 A;  4CQ5 A;  2PTR A;  2X0Q A;  1YIS A;  2K3O A;  2RJR A;  4APB A;  1T6J A;  5EYT A;  2A6E D;  3GTL A;  2MX8 A;  1KQ7 A;  2J91 A;  4MX2 A;  1U15 A;  2B63 A;  2EZB A;  1B8F A;  3EZE A;  2JA7 A;  2O6Y A;  2QVE A;  3U4Q A;  1K7W A;  3R6Y A;  3H0G A;  3CZO A;  1YFE A;  1K62 A;  1Q5N A;  2MQA A;  4CEH A;  4A15 A;  3NZ4 A;  2HWG A;  1DOF A;  3TV2 A;  2HRO A;  1SMY D;  3GTK A;  2O7F A;  1VDK A;  2A69 D;  2LYI A;  2PTS A;  1C3U A;  1I6V D;  2EZA A;  2VL7 A;  3NO9 A;  4NSL A;  5H8W A;  3OCE A;  2VSF A;  2FIP A;  1XL8 A;  1I50 A;  4ADL A;  1RE5 A;  2OHY A;  1ZYR D;  3EZA A;  3CQZ A;  2A68 D;  4HGV A;  1GKM A;  2O7B A;  2X0P A;  1YFM A;  3GTQ A;  2NYN A;  4EFC A;  4V2R A;  2RJS A;  3GTP A;  4NLE A;  5D6B A;  2VUM A;  2PTQ A;  1TWG A;  3U44 A;  1AUW A;  3CRW 1;  3UNV A;  1I3Q A;  1XMC A;  1WCM A;  2K3N A;  3RD8 A;  3RRP A;  2LKM B;  2JA6 A; 
#chains in the Genus database with same CATH homology
 1TJW A;  1J3U A;  1I0A A;  3C8T A;  4C6G A;  1FUO A;  1T6P A;  2QGA B;  1HY1 A;  2O78 A;  1TJU A;  1GK2 A;  5EYV A;  4BAB A;  1FUR A;  4EEI A;  1GKJ A;  2NYF A;  2YII A;  1TJV A;  1TJ7 A;  5F92 A;  3KDZ A;  2HVG A;  4C5S A;  4C5U A;  4V2Q A;  3GZH A;  1GK3 A;  1FUQ A;  3BHG A;  1XWO A;  2FUS A;  2VD6 A;  4APA A;  3OCF A;  3GTD A;  4BAA A;  1FUP A;  1JSW A;  2E9F A;  1EB4 A;  4C5R A;  3R6V A;  4ADM A;  3E04 A;  2X75 A;  1HY0 A;  1DCN A;  4FLC A;  2O7D A;  1Y2M A;  4FFX A;  1U16 A;  3QBP A;  2O7E A;  2PFM A;  5HW2 A;  1C3C A;  5F91 A;  3R6Q A;  3KDY A;  1W27 A;  4CQ5 A;  2PTR A;  1YIS A;  2RJR A;  4APB A;  1T6J A;  5EYT A;  1KQ7 A;  4MX2 A;  2J91 A;  1U15 A;  1B8F A;  2O6Y A;  2QVE A;  1K7W A;  3R6Y A;  3CZO A;  1YFE A;  1K62 A;  1Q5N A;  3NZ4 A;  1DOF A;  3TV2 A;  2O7F A;  1VDK A;  2PTS A;  1C3U A;  3NO9 A;  4NSL A;  3OCE A;  4ADL A;  1RE5 A;  2OHY A;  4HGV A;  1GKM A;  2O7B A;  1YFM A;  2NYN A;  4EFC A;  4V2R A;  2RJS A;  4NLE A;  5D6B A;  2PTQ A;  1AUW A;  3UNV A;  3RRP A;  3RD8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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