1IT6A

Crystal structure of the complex between calyculin a and the catalytic subunit of protein phosphatase 1
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
293
structure length
293
Chain Sequence
LNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the complex between calyculin A and the catalytic subunit of protein phosphatase 1.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords SERINE/THREONINE PROTEIN PHOSPHATASE 1 GAMMA (PP1-GAMMA) CAT
total genus 109
structure length 293
sequence length 293
chains with identical sequence B
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2002-01-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF16891 STPPase_N Serine-threonine protein phosphatase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 1it6A00
1XZWA 2BDXA 3THNA 3PSNA 3H60A 3QFOA 4V0XA 4KKZA 3QG5C 3GVEA 4B2OA 4G9JA 1XM7A 2HYPA 1V73A 2YVTA 4YKEA 3ZTVA 2Z1AA 4LTYA 3ZU0A 3H66A 5GTUA 4LU9A 4H2GA 4O5GA 2O8AA 3H68A 5JJTA 2BQ8X 2AHDA 1UTEA 3E7BA 3RQZA 1UF3A 1FJMA 5HPEA 1SU1A 4H1SA 5C1VA 2HYOA 4H2BA 5EQVA 3C5WC 2Z06A 1JK7A 2WDFA 4V0VA 4I5LC 4H2FA 2USHA 5B8IA 3LL8A 4XPNA 2GJUA 4HD0A 4ZX2A 1W24A 3C9FA 3RL5A 1S3LA 3IB7A 3QFNA 4MOVA 3FGAC 2QFRA 1NNWA 3KBPA 2WDEA 4MP0A 4O43A 3IVEA 2CV9A 3RL3A 1U32A 3AUZA 2Z72A 4I5NC 3IVDA 4ZVZA 1OIEA 1AUIA 2BCDA 3ICFA 1IT6A 3DW8C 3JYFA 1T71A 1M63A 1MF8A 1QFCA 4FCXA 4DHLA 3H64A 1KBPA 2IE4C 3H69A 4TUIA 5JPFA 3N5UA 5J28A 4UWQA 4DT2A 4OR9A 3PSOA 1USHA 3QFKA 4H2IA 1G5BA 4F0ZA 1T70A 5JPEA 3THOB 3V4YA 3H62B 1S3MA 2IE3C 4Q7FA 4O4KA 2QJCA 4V0WA 2Q8UA 2QFPA 5DNYA 4JA9A 4JA7A 4MOYA 4O24A 3H61A 1S70A 3DSDA 4H1YP 4DSYA 3RL4A 2O8GA 2NXFA 2A22A 3E7AA 1HPUA 4J6OA 1Z2WA 2KKNA 2HY1A 1WAO1 2P6BA 2NYLC 1WARA 3H67A 3CK2A 2XMOA 3H63A 2NYMC 2NPPC 2WDDA 3QFMA 4IYPC 5INBA 2JOGA 4FBWA 5IOHA 4UT2A 4NZVA 4M0VA 4FBQA 3EGHA 4LACC 1Z2XA 4IL1A 4ORBA 4TUGA 1S95A 1S3NA 1S8EA 1OI8A 1HO5A 3T1IA 4UT3A 3K7WC 3EGGA 3HVQA 2IAEC 3K7VC 3IB8A 5F3WA 3P71C 4ORCA 1TCOA 2R17A 4ORAA 2DFJA 3DSCA 3TGHA 1OIDA 1II7A 2ZBMA 3AV0A 4UT3B 4KBPA 1HP1A 1QHWA 4FBKA 2WDCA 4WWLA
chains in the Genus database with same CATH superfamily
1XZWA 3D03A 2DXLA 2BDXA 3THNA 3PSNA 3H60A 3QFOA 4V0XA 4KKZA 3QG5C 3GVEA 4B2OA 4G9JA 1XM7A 2HYPA 1V73A 2YVTA 4YKEA 3ZTVA 2Z1AA 4LTYA 3ZU0A 3H66A 5GTUA 4LU9A 4H2GA 4O5GA 2O8AA 3H68A 5JJTA 2BQ8X 2AHDA 1UTEA 3E7BA 3RQZA 1UF3A 1FJMA 5HPEA 1SU1A 4H1SA 5C1VA 2HYOA 4H2BA 5EQVA 3C5WC 2Z06A 1JK7A 2WDFA 4V0VA 4I5LC 4H2FA 2USHA 5B8IA 3LL8A 4XPNA 2GJUA 4HD0A 4ZX2A 1W24A 3C9FA 3RL5A 1S3LA 3IB7A 3QFNA 4MOVA 3FGAC 2QFRA 1NNWA 3KBPA 2WDEA 4MP0A 2DXNA 4O43A 3IVEA 2CV9A 3RL3A 1U32A 2ZO9B 3AUZA 2Z72A 4I5NC 3IVDA 4ZVZA 1OIEA 1AUIA 2BCDA 3ICFA 1IT6A 3DW8C 3JYFA 1T71A 1M63A 1MF8A 1QFCA 4FCXA 4DHLA 3H64A 1KBPA 2IE4C 3H69A 4TUIA 5JPFA 3N5UA 5J28A 4UWQA 4DT2A 3E0JA 4OR9A 3PSOA 1USHA 3QFKA 4H2IA 1G5BA 4F0ZA 1T70A 5JPEA 3THOB 3V4YA 3H62B 1S3MA 2IE3C 4Q7FA 2ZOAA 4O4KA 2QJCA 4V0WA 2Q8UA 2QFPA 5DNYA 4JA9A 4JA7A 4MOYA 4O24A 3H61A 1S70A 3DSDA 4H1YP 4DSYA 3RL4A 2O8GA 2NXFA 2A22A 3E7AA 1HPUA 4J6OA 1Z2WA 2KKNA 2HY1A 1WAO1 2P6BA 2NYLC 1WARA 2YEQA 3H67A 3CK2A 2XMOA 3H63A 2NYMC 2NPPC 2WDDA 3QFMA 4IYPC 5INBA 2JOGA 4FBWA 5IOHA 4UT2A 4NZVA 4M0VA 4FBQA 3EGHA 4LACC 1Z2XA 4IL1A 4ORBA 4TUGA 1S95A 1S3NA 1S8EA 1OI8A 1HO5A 3T1IA 4UT3A 3K7WC 3EGGA 3HVQA 2IAEC 3K7VC 3IB8A 5F3WA 3P71C 3FLOA 1TCOA 4ORCA 2R17A 4ORAA 2DFJA 3DSCA 3TGHA 1OIDA 1II7A 2ZBMA 3AV0A 4UT3B 4KBPA 1HP1A 1QHWA 4FBKA 2WDCA 4WWLA
chains in the Genus database with same CATH topology
1XZWA 3D03A 2DXLA 2BDXA 3THNA 3PSNA 3H60A 3QFOA 4V0XA 4KKZA 3QG5C 3GVEA 4B2OA 4G9JA 1XM7A 2HYPA 1V73A 2YVTA 4YKEA 3ZTVA 2Z1AA 4LTYA 3ZU0A 3H66A 5GTUA 4LU9A 4H2GA 4O5GA 2O8AA 3H68A 5JJTA 2BQ8X 2AHDA 1UTEA 3E7BA 3RQZA 1UF3A 1FJMA 5HPEA 1SU1A 4H1SA 5C1VA 2HYOA 4H2BA 5EQVA 3C5WC 2Z06A 1JK7A 2WDFA 4V0VA 4I5LC 4H2FA 2USHA 5B8IA 3LL8A 4XPNA 2GJUA 4HD0A 4ZX2A 1W24A 3C9FA 3RL5A 1S3LA 3IB7A 3QFNA 4MOVA 3FGAC 2QFRA 1NNWA 3KBPA 2WDEA 4MP0A 2DXNA 4O43A 3IVEA 2CV9A 3RL3A 1U32A 2ZO9B 3AUZA 2Z72A 4I5NC 3IVDA 4ZVZA 1OIEA 1AUIA 2BCDA 3ICFA 1IT6A 3DW8C 3JYFA 1T71A 1M63A 1MF8A 1QFCA 4FCXA 4DHLA 3H64A 1KBPA 2IE4C 3H69A 4TUIA 5JPFA 3N5UA 5J28A 4UWQA 4DT2A 3E0JA 4OR9A 3PSOA 1USHA 3QFKA 4H2IA 1G5BA 4F0ZA 1T70A 5JPEA 3THOB 3V4YA 3H62B 1S3MA 2IE3C 4Q7FA 2ZOAA 4O4KA 2QJCA 4V0WA 2Q8UA 2QFPA 5DNYA 4JA9A 4JA7A 4MOYA 4O24A 3H61A 1S70A 3DSDA 4H1YP 4DSYA 3RL4A 2O8GA 2NXFA 2A22A 3E7AA 1HPUA 4J6OA 1Z2WA 2KKNA 2HY1A 1WAO1 2P6BA 2NYLC 1WARA 2YEQA 3H67A 3CK2A 2XMOA 3H63A 2NYMC 2NPPC 2WDDA 3QFMA 4IYPC 5INBA 2JOGA 4FBWA 5IOHA 4UT2A 4NZVA 4M0VA 4FBQA 3EGHA 4LACC 1Z2XA 4IL1A 4ORBA 4TUGA 1S95A 1S3NA 1S8EA 1OI8A 1HO5A 3T1IA 4UT3A 3K7WC 3EGGA 3HVQA 2IAEC 3K7VC 3IB8A 5F3WA 3P71C 3FLOA 1TCOA 4ORCA 2R17A 4ORAA 2DFJA 3DSCA 3TGHA 1OIDA 1II7A 2ZBMA 3AV0A 4UT3B 4KBPA 1HP1A 1QHWA 4FBKA 2WDCA 4WWLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XZW A;  2BDX A;  3THN A;  3PSN A;  3H60 A;  3QFO A;  4V0X A;  4KKZ A;  3QG5 C;  3GVE A;  4B2O A;  4G9J A;  1XM7 A;  2HYP A;  1V73 A;  2YVT A;  4YKE A;  3ZTV A;  2Z1A A;  4LTY A;  3ZU0 A;  3H66 A;  5GTU A;  4LU9 A;  4H2G A;  4O5G A;  2O8A A;  3H68 A;  5JJT A;  2BQ8 X;  2AHD A;  1UTE A;  3E7B A;  3RQZ A;  1UF3 A;  1FJM A;  5HPE A;  1SU1 A;  4H1S A;  5C1V A;  2HYO A;  4H2B A;  5EQV A;  3C5W C;  2Z06 A;  1JK7 A;  2WDF A;  4V0V A;  4I5L C;  4H2F A;  2USH A;  5B8I A;  3LL8 A;  4XPN A;  2GJU A;  4HD0 A;  4ZX2 A;  1W24 A;  3C9F A;  3RL5 A;  1S3L A;  3IB7 A;  3QFN A;  4MOV A;  3FGA C;  2QFR A;  1NNW A;  3KBP A;  2WDE A;  4MP0 A;  4O43 A;  3IVE A;  2CV9 A;  3RL3 A;  1U32 A;  3AUZ A;  2Z72 A;  4I5N C;  3IVD A;  4ZVZ A;  1OIE A;  1AUI A;  2BCD A;  3ICF A;  1IT6 A;  3DW8 C;  3JYF A;  1T71 A;  1M63 A;  1MF8 A;  1QFC A;  4FCX A;  4DHL A;  3H64 A;  1KBP A;  2IE4 C;  3H69 A;  4TUI A;  5JPF A;  3N5U A;  5J28 A;  4UWQ A;  4DT2 A;  4OR9 A;  3PSO A;  1USH A;  3QFK A;  4H2I A;  1G5B A;  4F0Z A;  1T70 A;  5JPE A;  3THO B;  3V4Y A;  3H62 B;  1S3M A;  2IE3 C;  4Q7F A;  4O4K A;  2QJC A;  4V0W A;  2Q8U A;  2QFP A;  5DNY A;  4JA9 A;  4JA7 A;  4MOY A;  4O24 A;  3H61 A;  1S70 A;  3DSD A;  4H1Y P;  4DSY A;  3RL4 A;  2O8G A;  2NXF A;  2A22 A;  3E7A A;  1HPU A;  4J6O A;  1Z2W A;  2KKN A;  2HY1 A;  1WAO 1;  2P6B A;  2NYL C;  1WAR A;  3H67 A;  3CK2 A;  2XMO A;  3H63 A;  2NYM C;  2NPP C;  2WDD A;  3QFM A;  4IYP C;  5INB A;  2JOG A;  4FBW A;  5IOH A;  4UT2 A;  4NZV A;  4M0V A;  4FBQ A;  3EGH A;  4LAC C;  1Z2X A;  4IL1 A;  4ORB A;  4TUG A;  1S95 A;  1S3N A;  1S8E A;  1OI8 A;  1HO5 A;  3T1I A;  4UT3 A;  3K7W C;  3EGG A;  3HVQ A;  2IAE C;  3K7V C;  3IB8 A;  5F3W A;  3P71 C;  4ORC A;  1TCO A;  2R17 A;  4ORA A;  2DFJ A;  3DSC A;  3TGH A;  1OID A;  1II7 A;  2ZBM A;  3AV0 A;  4UT3 B;  4KBP A;  1HP1 A;  1QHW A;  4FBK A;  2WDC A;  4WWL A; 
#chains in the Genus database with same CATH topology
 1XZW A;  3D03 A;  2DXL A;  2BDX A;  3THN A;  3PSN A;  3H60 A;  3QFO A;  4V0X A;  4KKZ A;  3QG5 C;  3GVE A;  4B2O A;  4G9J A;  1XM7 A;  2HYP A;  1V73 A;  2YVT A;  4YKE A;  3ZTV A;  2Z1A A;  4LTY A;  3ZU0 A;  3H66 A;  5GTU A;  4LU9 A;  4H2G A;  4O5G A;  2O8A A;  3H68 A;  5JJT A;  2BQ8 X;  2AHD A;  1UTE A;  3E7B A;  3RQZ A;  1UF3 A;  1FJM A;  5HPE A;  1SU1 A;  4H1S A;  5C1V A;  2HYO A;  4H2B A;  5EQV A;  3C5W C;  2Z06 A;  1JK7 A;  2WDF A;  4V0V A;  4I5L C;  4H2F A;  2USH A;  5B8I A;  3LL8 A;  4XPN A;  2GJU A;  4HD0 A;  4ZX2 A;  1W24 A;  3C9F A;  3RL5 A;  1S3L A;  3IB7 A;  3QFN A;  4MOV A;  3FGA C;  2QFR A;  1NNW A;  3KBP A;  2WDE A;  4MP0 A;  2DXN A;  4O43 A;  3IVE A;  2CV9 A;  3RL3 A;  1U32 A;  2ZO9 B;  3AUZ A;  2Z72 A;  4I5N C;  3IVD A;  4ZVZ A;  1OIE A;  1AUI A;  2BCD A;  3ICF A;  1IT6 A;  3DW8 C;  3JYF A;  1T71 A;  1M63 A;  1MF8 A;  1QFC A;  4FCX A;  4DHL A;  3H64 A;  1KBP A;  2IE4 C;  3H69 A;  4TUI A;  5JPF A;  3N5U A;  5J28 A;  4UWQ A;  4DT2 A;  3E0J A;  4OR9 A;  3PSO A;  1USH A;  3QFK A;  4H2I A;  1G5B A;  4F0Z A;  1T70 A;  5JPE A;  3THO B;  3V4Y A;  3H62 B;  1S3M A;  2IE3 C;  4Q7F A;  2ZOA A;  4O4K A;  2QJC A;  4V0W A;  2Q8U A;  2QFP A;  5DNY A;  4JA9 A;  4JA7 A;  4MOY A;  4O24 A;  3H61 A;  1S70 A;  3DSD A;  4H1Y P;  4DSY A;  3RL4 A;  2O8G A;  2NXF A;  2A22 A;  3E7A A;  1HPU A;  4J6O A;  1Z2W A;  2KKN A;  2HY1 A;  1WAO 1;  2P6B A;  2NYL C;  1WAR A;  2YEQ A;  3H67 A;  3CK2 A;  2XMO A;  3H63 A;  2NYM C;  2NPP C;  2WDD A;  3QFM A;  4IYP C;  5INB A;  2JOG A;  4FBW A;  5IOH A;  4UT2 A;  4NZV A;  4M0V A;  4FBQ A;  3EGH A;  4LAC C;  1Z2X A;  4IL1 A;  4ORB A;  4TUG A;  1S95 A;  1S3N A;  1S8E A;  1OI8 A;  1HO5 A;  3T1I A;  4UT3 A;  3K7W C;  3EGG A;  3HVQ A;  2IAE C;  3K7V C;  3IB8 A;  5F3W A;  3P71 C;  3FLO A;  1TCO A;  4ORC A;  2R17 A;  4ORA A;  2DFJ A;  3DSC A;  3TGH A;  1OID A;  1II7 A;  2ZBM A;  3AV0 A;  4UT3 B;  4KBP A;  1HP1 A;  1QHW A;  4FBK A;  2WDC A;  4WWL A; 
#chains in the Genus database with same CATH homology
 1XZW A;  3D03 A;  2DXL A;  2BDX A;  3THN A;  3PSN A;  3H60 A;  3QFO A;  4V0X A;  4KKZ A;  3QG5 C;  3GVE A;  4B2O A;  4G9J A;  1XM7 A;  2HYP A;  1V73 A;  2YVT A;  4YKE A;  3ZTV A;  2Z1A A;  4LTY A;  3ZU0 A;  3H66 A;  5GTU A;  4LU9 A;  4H2G A;  4O5G A;  2O8A A;  3H68 A;  5JJT A;  2BQ8 X;  2AHD A;  1UTE A;  3E7B A;  3RQZ A;  1UF3 A;  1FJM A;  5HPE A;  1SU1 A;  4H1S A;  5C1V A;  2HYO A;  4H2B A;  5EQV A;  3C5W C;  2Z06 A;  1JK7 A;  2WDF A;  4V0V A;  4I5L C;  4H2F A;  2USH A;  5B8I A;  3LL8 A;  4XPN A;  2GJU A;  4HD0 A;  4ZX2 A;  1W24 A;  3C9F A;  3RL5 A;  1S3L A;  3IB7 A;  3QFN A;  4MOV A;  3FGA C;  2QFR A;  1NNW A;  3KBP A;  2WDE A;  4MP0 A;  2DXN A;  4O43 A;  3IVE A;  2CV9 A;  3RL3 A;  1U32 A;  2ZO9 B;  3AUZ A;  2Z72 A;  4I5N C;  3IVD A;  4ZVZ A;  1OIE A;  1AUI A;  2BCD A;  3ICF A;  1IT6 A;  3DW8 C;  3JYF A;  1T71 A;  1M63 A;  1MF8 A;  1QFC A;  4FCX A;  4DHL A;  3H64 A;  1KBP A;  2IE4 C;  3H69 A;  4TUI A;  5JPF A;  3N5U A;  5J28 A;  4UWQ A;  4DT2 A;  3E0J A;  4OR9 A;  3PSO A;  1USH A;  3QFK A;  4H2I A;  1G5B A;  4F0Z A;  1T70 A;  5JPE A;  3THO B;  3V4Y A;  3H62 B;  1S3M A;  2IE3 C;  4Q7F A;  2ZOA A;  4O4K A;  2QJC A;  4V0W A;  2Q8U A;  2QFP A;  5DNY A;  4JA9 A;  4JA7 A;  4MOY A;  4O24 A;  3H61 A;  1S70 A;  3DSD A;  4H1Y P;  4DSY A;  3RL4 A;  2O8G A;  2NXF A;  2A22 A;  3E7A A;  1HPU A;  4J6O A;  1Z2W A;  2KKN A;  2HY1 A;  1WAO 1;  2P6B A;  2NYL C;  1WAR A;  2YEQ A;  3H67 A;  3CK2 A;  2XMO A;  3H63 A;  2NYM C;  2NPP C;  2WDD A;  3QFM A;  4IYP C;  5INB A;  2JOG A;  4FBW A;  5IOH A;  4UT2 A;  4NZV A;  4M0V A;  4FBQ A;  3EGH A;  4LAC C;  1Z2X A;  4IL1 A;  4ORB A;  4TUG A;  1S95 A;  1S3N A;  1S8E A;  1OI8 A;  1HO5 A;  3T1I A;  4UT3 A;  3K7W C;  3EGG A;  3HVQ A;  2IAE C;  3K7V C;  3IB8 A;  5F3W A;  3P71 C;  3FLO A;  1TCO A;  4ORC A;  2R17 A;  4ORA A;  2DFJ A;  3DSC A;  3TGH A;  1OID A;  1II7 A;  2ZBM A;  3AV0 A;  4UT3 B;  4KBP A;  1HP1 A;  1QHW A;  4FBK A;  2WDC A;  4WWL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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