4H1YP

Human ecto-5'-nucleotidase (cd73): crystal form ii (open) in complex with psb11552
Total Genus 185
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
185
sequence length
524
structure length
524
Chain Sequence
PWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANISASGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHADEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTSCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords 5'-nucleotidase
total genus 185
structure length 524
sequence length 524
ec nomenclature ec 3.1.3.5: 5'-nucleotidase.
pdb deposition date 2012-09-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
P PF00149 Metallophos Calcineurin-like phosphoesterase
P PF02872 5_nucleotid_C 5'-nucleotidase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4h1yP01
3.90.780.10 Alpha Beta Alpha-Beta Complex 5'-nucleotidase; domain 2 5'-Nucleotidase, C-terminal domain 4h1yP02
4ZVZA 4G9JA 4OR9A 4H1SA 4UWQA 2DFJA 4I5NC 3DSDA 2O8GA 3H62B 4Q7FA 1JK7A 3EGGA 2HYPA 1TCOA 2KKNA 3GVEA 3THOB 4DSYA 1UTEA 2IE3C 2QFPA 4FBKA 4YKEA 4ZX2A 3DW8C 3H64A 1SU1A 2BQ8X 3AV0A 3H69A 4ORCA 2Z06A 3RL4A 2NYLC 2QFRA 4UT2A 5JPFA 4FBWA 4MP0A 4O5GA 1KBPA 2P6BA 5EQVA 1II7A 1S95A 1IT6A 2QJCA 4M0VA 1MF8A 3TGHA 3H61A 1Z2XA 1QFCA 5DNYA 3EGHA 2Z72A 4FCXA 3IVDA 4F0ZA 4WWLA 4JA7A 3K7VC 5INBA 5F3WA 1M63A 3HVQA 2A22A 2WDDA 4IYPC 1OI8A 1HPUA 1USHA 3QFMA 1OIEA 4KBPA 2HYOA 4DT2A 3K7WC 4V0XA 1OIDA 1XZWA 2BCDA 4LTYA 3E7BA 1V73A 2Z1AA 2CV9A 4I5LC 1S3MA 4V0VA 3QFNA 2O8AA 4NZVA 2XMOA 3QG5C 4DHLA 4J6OA 2R17A 3C5WC 2GJUA 2WDCA 4O4KA 3THNA 4H2IA 3H63A 3T1IA 5J28A 3E7AA 1XM7A 3C9FA 5B8IA 3RL3A 4ORBA 3ZTVA 1Z2WA 1HP1A 4HD0A 2JOGA 4LU9A 1S8EA 3H60A 1UF3A 3H67A 2NPPC 3P71C 3QFOA 3PSOA 5JPEA 3H66A 4UT3A 3IVEA 2IAEC 5HPEA 4LACC 1W24A 2AHDA 4UT3B 3N5UA 1FJMA 2HY1A 3KBPA 2NYMC 4H2GA 4H1YP 4KKZA 2BDXA 3ICFA 3LL8A 4XPNA 4B2OA 1T71A 3FGAC 1S3LA 2YVTA 4H2BA 4JA9A 1T70A 3IB7A 3JYFA 1S70A 3IB8A 4IL1A 5JJTA 4TUIA 4FBQA 3RQZA 5GTUA 3RL5A 1S3NA 3AUZA 3PSNA 2Q8UA 1U32A 5C1VA 4ORAA 1NNWA 2WDFA 3H68A 4MOVA 4O24A 1AUIA 5IOHA 2ZBMA 4H2FA 4TUGA 3V4YA 1QHWA 1HO5A 2IE4C 2WDEA 3CK2A 3QFKA 3DSCA 1WAO1 4O43A 4V0WA 2USHA 1G5BA 1WARA 4MOYA 3ZU0A 2NXFA
chains in the Genus database with same CATH superfamily
4ZVZA 4G9JA 4OR9A 4H1SA 4UWQA 2DFJA 3D03A 4I5NC 3DSDA 2O8GA 3H62B 4Q7FA 1JK7A 3EGGA 2HYPA 1TCOA 2KKNA 3GVEA 3THOB 4DSYA 1UTEA 2IE3C 2QFPA 4FBKA 4YKEA 4ZX2A 3DW8C 3H64A 1SU1A 2BQ8X 3AV0A 3H69A 4ORCA 2Z06A 3RL4A 2NYLC 2QFRA 4UT2A 5JPFA 2ZO9B 4FBWA 4MP0A 4O5GA 1KBPA 2P6BA 5EQVA 1II7A 1S95A 1IT6A 2QJCA 4M0VA 1MF8A 3TGHA 3H61A 1Z2XA 1QFCA 5DNYA 3EGHA 2Z72A 4FCXA 3IVDA 4F0ZA 4WWLA 4JA7A 3K7VC 5INBA 5F3WA 1M63A 3HVQA 2A22A 2WDDA 4IYPC 1OI8A 1HPUA 1USHA 3QFMA 1OIEA 4KBPA 2HYOA 4DT2A 3K7WC 4V0XA 1OIDA 1XZWA 2DXNA 2BCDA 4LTYA 3E7BA 1V73A 2Z1AA 2CV9A 4I5LC 1S3MA 4V0VA 3QFNA 2O8AA 4NZVA 2XMOA 3QG5C 4DHLA 4J6OA 2R17A 3C5WC 2GJUA 2WDCA 4O4KA 3THNA 4H2IA 3H63A 3T1IA 5J28A 3E7AA 1XM7A 3C9FA 2ZOAA 5B8IA 3RL3A 4ORBA 3ZTVA 1Z2WA 1HP1A 4HD0A 2JOGA 4LU9A 1S8EA 3H60A 1UF3A 3H67A 2NPPC 3P71C 3QFOA 3PSOA 5JPEA 3H66A 4UT3A 3IVEA 2IAEC 5HPEA 4LACC 1W24A 2AHDA 4UT3B 3N5UA 1FJMA 2HY1A 3KBPA 2NYMC 4H2GA 4H1YP 4KKZA 2BDXA 3ICFA 3LL8A 4XPNA 4B2OA 1T71A 3FGAC 1S3LA 3FLOA 2YVTA 4H2BA 4JA9A 1T70A 3IB7A 3E0JA 1S70A 3JYFA 3IB8A 4IL1A 5JJTA 4TUIA 2YEQA 4FBQA 3RQZA 5GTUA 3RL5A 1S3NA 3AUZA 3PSNA 2Q8UA 1U32A 2DXLA 5C1VA 4ORAA 1NNWA 2WDFA 3H68A 4MOVA 4O24A 1AUIA 5IOHA 2ZBMA 4H2FA 4TUGA 3V4YA 1QHWA 1HO5A 2IE4C 2WDEA 3CK2A 3QFKA 3DSCA 1WAO1 4O43A 4V0WA 2USHA 1G5BA 1WARA 4MOYA 3ZU0A 2NXFA
chains in the Genus database with same CATH topology
4ZVZA 4G9JA 4OR9A 4H1SA 4UWQA 2DFJA 3D03A 4I5NC 3DSDA 2O8GA 3H62B 4Q7FA 1JK7A 3EGGA 2HYPA 1TCOA 2KKNA 3GVEA 3THOB 4DSYA 1UTEA 2IE3C 2QFPA 4FBKA 4YKEA 4ZX2A 3DW8C 3H64A 1SU1A 2BQ8X 3AV0A 3H69A 4ORCA 2Z06A 3RL4A 2NYLC 2QFRA 4UT2A 5JPFA 2ZO9B 4FBWA 4MP0A 4O5GA 1KBPA 2P6BA 5EQVA 1II7A 1S95A 1IT6A 2QJCA 4M0VA 1MF8A 3TGHA 3H61A 1Z2XA 1QFCA 5DNYA 3EGHA 2Z72A 4FCXA 3IVDA 4F0ZA 4WWLA 4JA7A 3K7VC 5INBA 5F3WA 1M63A 3HVQA 2A22A 2WDDA 4IYPC 1OI8A 1HPUA 1USHA 3QFMA 1OIEA 4KBPA 2HYOA 4DT2A 3K7WC 4V0XA 1OIDA 1XZWA 2DXNA 2BCDA 4LTYA 3E7BA 1V73A 2Z1AA 2CV9A 4I5LC 1S3MA 4V0VA 3QFNA 2O8AA 4NZVA 2XMOA 3QG5C 4DHLA 4J6OA 2R17A 3C5WC 2GJUA 2WDCA 4O4KA 3THNA 4H2IA 3H63A 3T1IA 5J28A 3E7AA 1XM7A 3C9FA 2ZOAA 5B8IA 3RL3A 4ORBA 3ZTVA 1Z2WA 1HP1A 4HD0A 2JOGA 4LU9A 1S8EA 3H60A 1UF3A 3H67A 2NPPC 3P71C 3QFOA 3PSOA 5JPEA 3H66A 4UT3A 3IVEA 2IAEC 5HPEA 4LACC 1W24A 2AHDA 4UT3B 3N5UA 1FJMA 2HY1A 3KBPA 2NYMC 4H2GA 4H1YP 4KKZA 2BDXA 3ICFA 3LL8A 4XPNA 4B2OA 1T71A 3FGAC 1S3LA 3FLOA 2YVTA 4H2BA 4JA9A 1T70A 3IB7A 3E0JA 1S70A 3JYFA 3IB8A 4IL1A 5JJTA 4TUIA 2YEQA 4FBQA 3RQZA 5GTUA 3RL5A 1S3NA 3AUZA 3PSNA 2Q8UA 1U32A 2DXLA 5C1VA 4ORAA 1NNWA 2WDFA 3H68A 4MOVA 4O24A 1AUIA 5IOHA 2ZBMA 4H2FA 4TUGA 3V4YA 1QHWA 1HO5A 2IE4C 2WDEA 3CK2A 3QFKA 3DSCA 1WAO1 4O43A 4V0WA 2USHA 1G5BA 1WARA 4MOYA 3ZU0A 2NXFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZVZ A;  4G9J A;  4OR9 A;  4H1S A;  4UWQ A;  2DFJ A;  4I5N C;  3DSD A;  2O8G A;  3H62 B;  4Q7F A;  1JK7 A;  3EGG A;  2HYP A;  1TCO A;  2KKN A;  3GVE A;  3THO B;  4DSY A;  1UTE A;  2IE3 C;  2QFP A;  4FBK A;  4YKE A;  4ZX2 A;  3DW8 C;  3H64 A;  1SU1 A;  2BQ8 X;  3AV0 A;  3H69 A;  4ORC A;  2Z06 A;  3RL4 A;  2NYL C;  2QFR A;  4UT2 A;  5JPF A;  4FBW A;  4MP0 A;  4O5G A;  1KBP A;  2P6B A;  5EQV A;  1II7 A;  1S95 A;  1IT6 A;  2QJC A;  4M0V A;  1MF8 A;  3TGH A;  3H61 A;  1Z2X A;  1QFC A;  5DNY A;  3EGH A;  2Z72 A;  4FCX A;  3IVD A;  4F0Z A;  4WWL A;  4JA7 A;  3K7V C;  5INB A;  5F3W A;  1M63 A;  3HVQ A;  2A22 A;  2WDD A;  4IYP C;  1OI8 A;  1HPU A;  1USH A;  3QFM A;  1OIE A;  4KBP A;  2HYO A;  4DT2 A;  3K7W C;  4V0X A;  1OID A;  1XZW A;  2BCD A;  4LTY A;  3E7B A;  1V73 A;  2Z1A A;  2CV9 A;  4I5L C;  1S3M A;  4V0V A;  3QFN A;  2O8A A;  4NZV A;  2XMO A;  3QG5 C;  4DHL A;  4J6O A;  2R17 A;  3C5W C;  2GJU A;  2WDC A;  4O4K A;  3THN A;  4H2I A;  3H63 A;  3T1I A;  5J28 A;  3E7A A;  1XM7 A;  3C9F A;  5B8I A;  3RL3 A;  4ORB A;  3ZTV A;  1Z2W A;  1HP1 A;  4HD0 A;  2JOG A;  4LU9 A;  1S8E A;  3H60 A;  1UF3 A;  3H67 A;  2NPP C;  3P71 C;  3QFO A;  3PSO A;  5JPE A;  3H66 A;  4UT3 A;  3IVE A;  2IAE C;  5HPE A;  4LAC C;  1W24 A;  2AHD A;  4UT3 B;  3N5U A;  1FJM A;  2HY1 A;  3KBP A;  2NYM C;  4H2G A;  4H1Y P;  4KKZ A;  2BDX A;  3ICF A;  3LL8 A;  4XPN A;  4B2O A;  1T71 A;  3FGA C;  1S3L A;  2YVT A;  4H2B A;  4JA9 A;  1T70 A;  3IB7 A;  3JYF A;  1S70 A;  3IB8 A;  4IL1 A;  5JJT A;  4TUI A;  4FBQ A;  3RQZ A;  5GTU A;  3RL5 A;  1S3N A;  3AUZ A;  3PSN A;  2Q8U A;  1U32 A;  5C1V A;  4ORA A;  1NNW A;  2WDF A;  3H68 A;  4MOV A;  4O24 A;  1AUI A;  5IOH A;  2ZBM A;  4H2F A;  4TUG A;  3V4Y A;  1QHW A;  1HO5 A;  2IE4 C;  2WDE A;  3CK2 A;  3QFK A;  3DSC A;  1WAO 1;  4O43 A;  4V0W A;  2USH A;  1G5B A;  1WAR A;  4MOY A;  3ZU0 A;  2NXF A; 
#chains in the Genus database with same CATH topology
 4ZVZ A;  4G9J A;  4OR9 A;  4H1S A;  4UWQ A;  2DFJ A;  3D03 A;  4I5N C;  3DSD A;  2O8G A;  3H62 B;  4Q7F A;  1JK7 A;  3EGG A;  2HYP A;  1TCO A;  2KKN A;  3GVE A;  3THO B;  4DSY A;  1UTE A;  2IE3 C;  2QFP A;  4FBK A;  4YKE A;  4ZX2 A;  3DW8 C;  3H64 A;  1SU1 A;  2BQ8 X;  3AV0 A;  3H69 A;  4ORC A;  2Z06 A;  3RL4 A;  2NYL C;  2QFR A;  4UT2 A;  5JPF A;  2ZO9 B;  4FBW A;  4MP0 A;  4O5G A;  1KBP A;  2P6B A;  5EQV A;  1II7 A;  1S95 A;  1IT6 A;  2QJC A;  4M0V A;  1MF8 A;  3TGH A;  3H61 A;  1Z2X A;  1QFC A;  5DNY A;  3EGH A;  2Z72 A;  4FCX A;  3IVD A;  4F0Z A;  4WWL A;  4JA7 A;  3K7V C;  5INB A;  5F3W A;  1M63 A;  3HVQ A;  2A22 A;  2WDD A;  4IYP C;  1OI8 A;  1HPU A;  1USH A;  3QFM A;  1OIE A;  4KBP A;  2HYO A;  4DT2 A;  3K7W C;  4V0X A;  1OID A;  1XZW A;  2DXN A;  2BCD A;  4LTY A;  3E7B A;  1V73 A;  2Z1A A;  2CV9 A;  4I5L C;  1S3M A;  4V0V A;  3QFN A;  2O8A A;  4NZV A;  2XMO A;  3QG5 C;  4DHL A;  4J6O A;  2R17 A;  3C5W C;  2GJU A;  2WDC A;  4O4K A;  3THN A;  4H2I A;  3H63 A;  3T1I A;  5J28 A;  3E7A A;  1XM7 A;  3C9F A;  2ZOA A;  5B8I A;  3RL3 A;  4ORB A;  3ZTV A;  1Z2W A;  1HP1 A;  4HD0 A;  2JOG A;  4LU9 A;  1S8E A;  3H60 A;  1UF3 A;  3H67 A;  2NPP C;  3P71 C;  3QFO A;  3PSO A;  5JPE A;  3H66 A;  4UT3 A;  3IVE A;  2IAE C;  5HPE A;  4LAC C;  1W24 A;  2AHD A;  4UT3 B;  3N5U A;  1FJM A;  2HY1 A;  3KBP A;  2NYM C;  4H2G A;  4H1Y P;  4KKZ A;  2BDX A;  3ICF A;  3LL8 A;  4XPN A;  4B2O A;  1T71 A;  3FGA C;  1S3L A;  3FLO A;  2YVT A;  4H2B A;  4JA9 A;  1T70 A;  3IB7 A;  3E0J A;  1S70 A;  3JYF A;  3IB8 A;  4IL1 A;  5JJT A;  4TUI A;  2YEQ A;  4FBQ A;  3RQZ A;  5GTU A;  3RL5 A;  1S3N A;  3AUZ A;  3PSN A;  2Q8U A;  1U32 A;  2DXL A;  5C1V A;  4ORA A;  1NNW A;  2WDF A;  3H68 A;  4MOV A;  4O24 A;  1AUI A;  5IOH A;  2ZBM A;  4H2F A;  4TUG A;  3V4Y A;  1QHW A;  1HO5 A;  2IE4 C;  2WDE A;  3CK2 A;  3QFK A;  3DSC A;  1WAO 1;  4O43 A;  4V0W A;  2USH A;  1G5B A;  1WAR A;  4MOY A;  3ZU0 A;  2NXF A; 
#chains in the Genus database with same CATH homology
 4ZVZ A;  4G9J A;  4OR9 A;  4H1S A;  4UWQ A;  2DFJ A;  3D03 A;  4I5N C;  3DSD A;  2O8G A;  3H62 B;  4Q7F A;  1JK7 A;  3EGG A;  2HYP A;  1TCO A;  2KKN A;  3GVE A;  3THO B;  4DSY A;  1UTE A;  2IE3 C;  2QFP A;  4FBK A;  4YKE A;  4ZX2 A;  3DW8 C;  3H64 A;  1SU1 A;  2BQ8 X;  3AV0 A;  3H69 A;  4ORC A;  2Z06 A;  3RL4 A;  2NYL C;  2QFR A;  4UT2 A;  5JPF A;  2ZO9 B;  4FBW A;  4MP0 A;  4O5G A;  1KBP A;  2P6B A;  5EQV A;  1II7 A;  1S95 A;  1IT6 A;  2QJC A;  4M0V A;  1MF8 A;  3TGH A;  3H61 A;  1Z2X A;  1QFC A;  5DNY A;  3EGH A;  2Z72 A;  4FCX A;  3IVD A;  4F0Z A;  4WWL A;  4JA7 A;  3K7V C;  5INB A;  5F3W A;  1M63 A;  3HVQ A;  2A22 A;  2WDD A;  4IYP C;  1OI8 A;  1HPU A;  1USH A;  3QFM A;  1OIE A;  4KBP A;  2HYO A;  4DT2 A;  3K7W C;  4V0X A;  1OID A;  1XZW A;  2DXN A;  2BCD A;  4LTY A;  3E7B A;  1V73 A;  2Z1A A;  2CV9 A;  4I5L C;  1S3M A;  4V0V A;  3QFN A;  2O8A A;  4NZV A;  2XMO A;  3QG5 C;  4DHL A;  4J6O A;  2R17 A;  3C5W C;  2GJU A;  2WDC A;  4O4K A;  3THN A;  4H2I A;  3H63 A;  3T1I A;  5J28 A;  3E7A A;  1XM7 A;  3C9F A;  2ZOA A;  5B8I A;  3RL3 A;  4ORB A;  3ZTV A;  1Z2W A;  1HP1 A;  4HD0 A;  2JOG A;  4LU9 A;  1S8E A;  3H60 A;  1UF3 A;  3H67 A;  2NPP C;  3P71 C;  3QFO A;  3PSO A;  5JPE A;  3H66 A;  4UT3 A;  3IVE A;  2IAE C;  5HPE A;  4LAC C;  1W24 A;  2AHD A;  4UT3 B;  3N5U A;  1FJM A;  2HY1 A;  3KBP A;  2NYM C;  4H2G A;  4H1Y P;  4KKZ A;  2BDX A;  3ICF A;  3LL8 A;  4XPN A;  4B2O A;  1T71 A;  3FGA C;  1S3L A;  3FLO A;  2YVT A;  4H2B A;  4JA9 A;  1T70 A;  3IB7 A;  3E0J A;  1S70 A;  3JYF A;  3IB8 A;  4IL1 A;  5JJT A;  4TUI A;  2YEQ A;  4FBQ A;  3RQZ A;  5GTU A;  3RL5 A;  1S3N A;  3AUZ A;  3PSN A;  2Q8U A;  1U32 A;  2DXL A;  5C1V A;  4ORA A;  1NNW A;  2WDF A;  3H68 A;  4MOV A;  4O24 A;  1AUI A;  5IOH A;  2ZBM A;  4H2F A;  4TUG A;  3V4Y A;  1QHW A;  1HO5 A;  2IE4 C;  2WDE A;  3CK2 A;  3QFK A;  3DSC A;  1WAO 1;  4O43 A;  4V0W A;  2USH A;  1G5B A;  1WAR A;  4MOY A;  3ZU0 A;  2NXF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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