4H1YP

Human ecto-5'-nucleotidase (cd73): crystal form ii (open) in complex with psb11552
Total Genus 185
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
185
sequence length
524
structure length
524
Chain Sequence
PWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANISASGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHADEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTSCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords 5'-nucleotidase
total genus 185
structure length 524
sequence length 524
ec nomenclature ec 3.1.3.5: 5'-nucleotidase.
pdb deposition date 2012-09-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
P PF00149 Metallophos Calcineurin-like phosphoesterase
P PF02872 5_nucleotid_C 5'-nucleotidase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4h1yP01
3.90.780.10 Alpha Beta Alpha-Beta Complex 5'-nucleotidase; domain 2 5'-Nucleotidase, C-terminal domain 4h1yP02
3IB8A 4H2FA 4ZX2A 2HY1A 4LTYA 5GTUA 1KBPA 2IAEC 3LL8A 1NNWA 2BQ8X 2CV9A 2IE3C 4ZVZA 1Z2WA 2WDEA 1OIEA 1JK7A 1SU1A 3HVQA 4MP0A 1WAO1 2WDFA 3C5WC 2HYPA 3DSCA 3E7AA 3K7VC 2KKNA 3EGGA 2IE4C 1IT6A 5B8IA 1S3MA 1V73A 2Q8UA 3THNA 4O5GA 3QFOA 4H1SA 4H2GA 4H2BA 5JPEA 4IYPC 3TGHA 3EGHA 4HD0A 3QFKA 3ZTVA 3H66A 1T70A 3CK2A 1TCOA 1HO5A 2QJCA 1AUIA 4KBPA 3ICFA 2YVTA 4H1YP 3H60A 4M0VA 2P6BA 3RL3A 4ORCA 3FGAC 3QFNA 4F0ZA 3AV0A 1USHA 4IL1A 3DW8C 2A22A 3JYFA 5HPEA 3RQZA 1II7A 1QFCA 2Z1AA 3E7BA 4MOYA 4OR9A 5J28A 4FCXA 2JOGA 2Z06A 3IB7A 1S95A 1S8EA 3GVEA 4FBQA 4WWLA 3N5UA 4V0XA 4FBKA 3C9FA 3RL4A 4O43A 1S70A 2R17A 1UF3A 4YKEA 3H63A 4DT2A 4FBWA 2DFJA 4B2OA 3H62B 4I5LC 3IVEA 4J6OA 2USHA 3H68A 4UWQA 4UT3A 2AHDA 3H61A 4DHLA 1XM7A 5JJTA 4UT3B 1QHWA 2WDCA 2O8AA 3H69A 3IVDA 1OI8A 3THOB 1M63A 3K7WC 3QG5C 2NXFA 4TUIA 1FJMA 4ORAA 5DNYA 1HP1A 4XPNA 3H64A 1Z2XA 4JA9A 2NYLC 1S3LA 3H67A 3ZU0A 4V0VA 1T71A 1HPUA 2O8GA 4MOVA 3P71C 3V4YA 2GJUA 4KKZA 2ZBMA 4LU9A 1S3NA 3T1IA 5IOHA 4TUGA 4H2IA 4O4KA 2HYOA 5INBA 1UTEA 1MF8A 2QFRA 3KBPA 3RL5A 1G5BA 5F3WA 3DSDA 5C1VA 4G9JA 2XMOA 1U32A 1XZWA 3QFMA 4NZVA 1WARA 4LACC 3PSOA 4JA7A 4V0WA 5EQVA 4I5NC 5JPFA 2BDXA 2NPPC 1W24A 2QFPA 4DSYA 1OIDA 2Z72A 3PSNA 3AUZA 4O24A 2BCDA 2NYMC 4ORBA 4Q7FA 4UT2A 2WDDA
chains in the Genus database with same CATH superfamily
3IB8A 4H2FA 4ZX2A 2HY1A 4LTYA 5GTUA 1KBPA 2IAEC 3LL8A 1NNWA 2BQ8X 2CV9A 2IE3C 4ZVZA 1Z2WA 2WDEA 1OIEA 1JK7A 1SU1A 3HVQA 4MP0A 1WAO1 2WDFA 3C5WC 2HYPA 3DSCA 3E7AA 3K7VC 2KKNA 3EGGA 2IE4C 1IT6A 5B8IA 1S3MA 1V73A 2Q8UA 3THNA 4O5GA 3QFOA 4H1SA 4H2GA 4H2BA 5JPEA 4IYPC 3TGHA 3EGHA 4HD0A 3QFKA 3ZTVA 3H66A 1T70A 3CK2A 1TCOA 1HO5A 2QJCA 1AUIA 4KBPA 3ICFA 2YVTA 4H1YP 3H60A 4M0VA 2P6BA 3RL3A 4ORCA 3FGAC 3QFNA 4F0ZA 3AV0A 1USHA 2YEQA 3DW8C 2A22A 3JYFA 4IL1A 2ZO9B 3RQZA 1II7A 2DXNA 1QFCA 2Z1AA 5HPEA 3E7BA 4MOYA 3FLOA 4OR9A 5J28A 4FCXA 2JOGA 2Z06A 3IB7A 1S95A 1S8EA 3GVEA 4FBQA 4WWLA 3N5UA 4V0XA 4FBKA 3C9FA 3RL4A 4O43A 1S70A 2R17A 1UF3A 3D03A 3H63A 4YKEA 4FBWA 2DFJA 4B2OA 3H62B 4I5LC 4DT2A 3IVEA 4J6OA 2USHA 3H68A 4UWQA 4UT3A 2AHDA 3H61A 4DHLA 1XM7A 5JJTA 4UT3B 1QHWA 2WDCA 2ZOAA 2O8AA 3H69A 3IVDA 1OI8A 3THOB 1M63A 3K7WC 3QG5C 2NXFA 4TUIA 1FJMA 4ORAA 5DNYA 1HP1A 4XPNA 3H64A 1Z2XA 3E0JA 2NYLC 1S3LA 3H67A 4JA9A 3ZU0A 4V0VA 1T71A 1HPUA 2O8GA 4MOVA 3P71C 3V4YA 2GJUA 4KKZA 2ZBMA 4LU9A 1S3NA 3T1IA 5IOHA 4TUGA 4H2IA 4O4KA 2HYOA 5INBA 1UTEA 1MF8A 2QFRA 3KBPA 3RL5A 1G5BA 5F3WA 3DSDA 2DXLA 5C1VA 4G9JA 2XMOA 1U32A 1XZWA 3QFMA 4NZVA 1WARA 4LACC 3PSOA 4JA7A 4V0WA 5EQVA 4I5NC 5JPFA 2BDXA 2NPPC 1W24A 2QFPA 4DSYA 1OIDA 2Z72A 3PSNA 3AUZA 4O24A 2BCDA 2NYMC 4ORBA 4Q7FA 4UT2A 2WDDA
chains in the Genus database with same CATH topology
3IB8A 4H2FA 4ZX2A 2HY1A 4LTYA 5GTUA 1KBPA 2IAEC 3LL8A 1NNWA 2BQ8X 2CV9A 2IE3C 4ZVZA 1Z2WA 2WDEA 1OIEA 1JK7A 1SU1A 3HVQA 4MP0A 1WAO1 2WDFA 3C5WC 2HYPA 3DSCA 3E7AA 3K7VC 2KKNA 3EGGA 2IE4C 1IT6A 5B8IA 1S3MA 1V73A 2Q8UA 3THNA 4O5GA 3QFOA 4H1SA 4H2GA 4H2BA 5JPEA 4IYPC 3TGHA 3EGHA 4HD0A 3QFKA 3ZTVA 3H66A 1T70A 3CK2A 1TCOA 1HO5A 2QJCA 1AUIA 4KBPA 3ICFA 2YVTA 4H1YP 3H60A 4M0VA 2P6BA 3RL3A 4ORCA 3FGAC 3QFNA 4F0ZA 3AV0A 1USHA 2YEQA 3DW8C 2A22A 3JYFA 4IL1A 2ZO9B 3RQZA 1II7A 2DXNA 1QFCA 2Z1AA 5HPEA 3E7BA 4MOYA 3FLOA 4OR9A 5J28A 4FCXA 2JOGA 2Z06A 3IB7A 1S95A 1S8EA 3GVEA 4FBQA 4WWLA 3N5UA 4V0XA 4FBKA 3C9FA 3RL4A 4O43A 1S70A 2R17A 1UF3A 3D03A 3H63A 4YKEA 4FBWA 2DFJA 4B2OA 3H62B 4I5LC 4DT2A 3IVEA 4J6OA 2USHA 3H68A 4UWQA 4UT3A 2AHDA 3H61A 4DHLA 1XM7A 5JJTA 4UT3B 1QHWA 2WDCA 2ZOAA 2O8AA 3H69A 3IVDA 1OI8A 3THOB 1M63A 3K7WC 3QG5C 2NXFA 4TUIA 1FJMA 4ORAA 5DNYA 1HP1A 4XPNA 3H64A 1Z2XA 3E0JA 2NYLC 1S3LA 3H67A 4JA9A 3ZU0A 4V0VA 1T71A 1HPUA 2O8GA 4MOVA 3P71C 3V4YA 2GJUA 4KKZA 2ZBMA 4LU9A 1S3NA 3T1IA 5IOHA 4TUGA 4H2IA 4O4KA 2HYOA 5INBA 1UTEA 1MF8A 2QFRA 3KBPA 3RL5A 1G5BA 5F3WA 3DSDA 2DXLA 5C1VA 4G9JA 2XMOA 1U32A 1XZWA 3QFMA 4NZVA 1WARA 4LACC 3PSOA 4JA7A 4V0WA 5EQVA 4I5NC 5JPFA 2BDXA 2NPPC 1W24A 2QFPA 4DSYA 1OIDA 2Z72A 3PSNA 3AUZA 4O24A 2BCDA 2NYMC 4ORBA 4Q7FA 4UT2A 2WDDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IB8 A;  4H2F A;  4ZX2 A;  2HY1 A;  4LTY A;  5GTU A;  1KBP A;  2IAE C;  3LL8 A;  1NNW A;  2BQ8 X;  2CV9 A;  2IE3 C;  4ZVZ A;  1Z2W A;  2WDE A;  1OIE A;  1JK7 A;  1SU1 A;  3HVQ A;  4MP0 A;  1WAO 1;  2WDF A;  3C5W C;  2HYP A;  3DSC A;  3E7A A;  3K7V C;  2KKN A;  3EGG A;  2IE4 C;  1IT6 A;  5B8I A;  1S3M A;  1V73 A;  2Q8U A;  3THN A;  4O5G A;  3QFO A;  4H1S A;  4H2G A;  4H2B A;  5JPE A;  4IYP C;  3TGH A;  3EGH A;  4HD0 A;  3QFK A;  3ZTV A;  3H66 A;  1T70 A;  3CK2 A;  1TCO A;  1HO5 A;  2QJC A;  1AUI A;  4KBP A;  3ICF A;  2YVT A;  4H1Y P;  3H60 A;  4M0V A;  2P6B A;  3RL3 A;  4ORC A;  3FGA C;  3QFN A;  4F0Z A;  3AV0 A;  1USH A;  4IL1 A;  3DW8 C;  2A22 A;  3JYF A;  5HPE A;  3RQZ A;  1II7 A;  1QFC A;  2Z1A A;  3E7B A;  4MOY A;  4OR9 A;  5J28 A;  4FCX A;  2JOG A;  2Z06 A;  3IB7 A;  1S95 A;  1S8E A;  3GVE A;  4FBQ A;  4WWL A;  3N5U A;  4V0X A;  4FBK A;  3C9F A;  3RL4 A;  4O43 A;  1S70 A;  2R17 A;  1UF3 A;  4YKE A;  3H63 A;  4DT2 A;  4FBW A;  2DFJ A;  4B2O A;  3H62 B;  4I5L C;  3IVE A;  4J6O A;  2USH A;  3H68 A;  4UWQ A;  4UT3 A;  2AHD A;  3H61 A;  4DHL A;  1XM7 A;  5JJT A;  4UT3 B;  1QHW A;  2WDC A;  2O8A A;  3H69 A;  3IVD A;  1OI8 A;  3THO B;  1M63 A;  3K7W C;  3QG5 C;  2NXF A;  4TUI A;  1FJM A;  4ORA A;  5DNY A;  1HP1 A;  4XPN A;  3H64 A;  1Z2X A;  4JA9 A;  2NYL C;  1S3L A;  3H67 A;  3ZU0 A;  4V0V A;  1T71 A;  1HPU A;  2O8G A;  4MOV A;  3P71 C;  3V4Y A;  2GJU A;  4KKZ A;  2ZBM A;  4LU9 A;  1S3N A;  3T1I A;  5IOH A;  4TUG A;  4H2I A;  4O4K A;  2HYO A;  5INB A;  1UTE A;  1MF8 A;  2QFR A;  3KBP A;  3RL5 A;  1G5B A;  5F3W A;  3DSD A;  5C1V A;  4G9J A;  2XMO A;  1U32 A;  1XZW A;  3QFM A;  4NZV A;  1WAR A;  4LAC C;  3PSO A;  4JA7 A;  4V0W A;  5EQV A;  4I5N C;  5JPF A;  2BDX A;  2NPP C;  1W24 A;  2QFP A;  4DSY A;  1OID A;  2Z72 A;  3PSN A;  3AUZ A;  4O24 A;  2BCD A;  2NYM C;  4ORB A;  4Q7F A;  4UT2 A;  2WDD A; 
#chains in the Genus database with same CATH topology
 3IB8 A;  4H2F A;  4ZX2 A;  2HY1 A;  4LTY A;  5GTU A;  1KBP A;  2IAE C;  3LL8 A;  1NNW A;  2BQ8 X;  2CV9 A;  2IE3 C;  4ZVZ A;  1Z2W A;  2WDE A;  1OIE A;  1JK7 A;  1SU1 A;  3HVQ A;  4MP0 A;  1WAO 1;  2WDF A;  3C5W C;  2HYP A;  3DSC A;  3E7A A;  3K7V C;  2KKN A;  3EGG A;  2IE4 C;  1IT6 A;  5B8I A;  1S3M A;  1V73 A;  2Q8U A;  3THN A;  4O5G A;  3QFO A;  4H1S A;  4H2G A;  4H2B A;  5JPE A;  4IYP C;  3TGH A;  3EGH A;  4HD0 A;  3QFK A;  3ZTV A;  3H66 A;  1T70 A;  3CK2 A;  1TCO A;  1HO5 A;  2QJC A;  1AUI A;  4KBP A;  3ICF A;  2YVT A;  4H1Y P;  3H60 A;  4M0V A;  2P6B A;  3RL3 A;  4ORC A;  3FGA C;  3QFN A;  4F0Z A;  3AV0 A;  1USH A;  2YEQ A;  3DW8 C;  2A22 A;  3JYF A;  4IL1 A;  2ZO9 B;  3RQZ A;  1II7 A;  2DXN A;  1QFC A;  2Z1A A;  5HPE A;  3E7B A;  4MOY A;  3FLO A;  4OR9 A;  5J28 A;  4FCX A;  2JOG A;  2Z06 A;  3IB7 A;  1S95 A;  1S8E A;  3GVE A;  4FBQ A;  4WWL A;  3N5U A;  4V0X A;  4FBK A;  3C9F A;  3RL4 A;  4O43 A;  1S70 A;  2R17 A;  1UF3 A;  3D03 A;  3H63 A;  4YKE A;  4FBW A;  2DFJ A;  4B2O A;  3H62 B;  4I5L C;  4DT2 A;  3IVE A;  4J6O A;  2USH A;  3H68 A;  4UWQ A;  4UT3 A;  2AHD A;  3H61 A;  4DHL A;  1XM7 A;  5JJT A;  4UT3 B;  1QHW A;  2WDC A;  2ZOA A;  2O8A A;  3H69 A;  3IVD A;  1OI8 A;  3THO B;  1M63 A;  3K7W C;  3QG5 C;  2NXF A;  4TUI A;  1FJM A;  4ORA A;  5DNY A;  1HP1 A;  4XPN A;  3H64 A;  1Z2X A;  3E0J A;  2NYL C;  1S3L A;  3H67 A;  4JA9 A;  3ZU0 A;  4V0V A;  1T71 A;  1HPU A;  2O8G A;  4MOV A;  3P71 C;  3V4Y A;  2GJU A;  4KKZ A;  2ZBM A;  4LU9 A;  1S3N A;  3T1I A;  5IOH A;  4TUG A;  4H2I A;  4O4K A;  2HYO A;  5INB A;  1UTE A;  1MF8 A;  2QFR A;  3KBP A;  3RL5 A;  1G5B A;  5F3W A;  3DSD A;  2DXL A;  5C1V A;  4G9J A;  2XMO A;  1U32 A;  1XZW A;  3QFM A;  4NZV A;  1WAR A;  4LAC C;  3PSO A;  4JA7 A;  4V0W A;  5EQV A;  4I5N C;  5JPF A;  2BDX A;  2NPP C;  1W24 A;  2QFP A;  4DSY A;  1OID A;  2Z72 A;  3PSN A;  3AUZ A;  4O24 A;  2BCD A;  2NYM C;  4ORB A;  4Q7F A;  4UT2 A;  2WDD A; 
#chains in the Genus database with same CATH homology
 3IB8 A;  4H2F A;  4ZX2 A;  2HY1 A;  4LTY A;  5GTU A;  1KBP A;  2IAE C;  3LL8 A;  1NNW A;  2BQ8 X;  2CV9 A;  2IE3 C;  4ZVZ A;  1Z2W A;  2WDE A;  1OIE A;  1JK7 A;  1SU1 A;  3HVQ A;  4MP0 A;  1WAO 1;  2WDF A;  3C5W C;  2HYP A;  3DSC A;  3E7A A;  3K7V C;  2KKN A;  3EGG A;  2IE4 C;  1IT6 A;  5B8I A;  1S3M A;  1V73 A;  2Q8U A;  3THN A;  4O5G A;  3QFO A;  4H1S A;  4H2G A;  4H2B A;  5JPE A;  4IYP C;  3TGH A;  3EGH A;  4HD0 A;  3QFK A;  3ZTV A;  3H66 A;  1T70 A;  3CK2 A;  1TCO A;  1HO5 A;  2QJC A;  1AUI A;  4KBP A;  3ICF A;  2YVT A;  4H1Y P;  3H60 A;  4M0V A;  2P6B A;  3RL3 A;  4ORC A;  3FGA C;  3QFN A;  4F0Z A;  3AV0 A;  1USH A;  2YEQ A;  3DW8 C;  2A22 A;  3JYF A;  4IL1 A;  2ZO9 B;  3RQZ A;  1II7 A;  2DXN A;  1QFC A;  2Z1A A;  5HPE A;  3E7B A;  4MOY A;  3FLO A;  4OR9 A;  5J28 A;  4FCX A;  2JOG A;  2Z06 A;  3IB7 A;  1S95 A;  1S8E A;  3GVE A;  4FBQ A;  4WWL A;  3N5U A;  4V0X A;  4FBK A;  3C9F A;  3RL4 A;  4O43 A;  1S70 A;  2R17 A;  1UF3 A;  3D03 A;  3H63 A;  4YKE A;  4FBW A;  2DFJ A;  4B2O A;  3H62 B;  4I5L C;  4DT2 A;  3IVE A;  4J6O A;  2USH A;  3H68 A;  4UWQ A;  4UT3 A;  2AHD A;  3H61 A;  4DHL A;  1XM7 A;  5JJT A;  4UT3 B;  1QHW A;  2WDC A;  2ZOA A;  2O8A A;  3H69 A;  3IVD A;  1OI8 A;  3THO B;  1M63 A;  3K7W C;  3QG5 C;  2NXF A;  4TUI A;  1FJM A;  4ORA A;  5DNY A;  1HP1 A;  4XPN A;  3H64 A;  1Z2X A;  3E0J A;  2NYL C;  1S3L A;  3H67 A;  4JA9 A;  3ZU0 A;  4V0V A;  1T71 A;  1HPU A;  2O8G A;  4MOV A;  3P71 C;  3V4Y A;  2GJU A;  4KKZ A;  2ZBM A;  4LU9 A;  1S3N A;  3T1I A;  5IOH A;  4TUG A;  4H2I A;  4O4K A;  2HYO A;  5INB A;  1UTE A;  1MF8 A;  2QFR A;  3KBP A;  3RL5 A;  1G5B A;  5F3W A;  3DSD A;  2DXL A;  5C1V A;  4G9J A;  2XMO A;  1U32 A;  1XZW A;  3QFM A;  4NZV A;  1WAR A;  4LAC C;  3PSO A;  4JA7 A;  4V0W A;  5EQV A;  4I5N C;  5JPF A;  2BDX A;  2NPP C;  1W24 A;  2QFP A;  4DSY A;  1OID A;  2Z72 A;  3PSN A;  3AUZ A;  4O24 A;  2BCD A;  2NYM C;  4ORB A;  4Q7F A;  4UT2 A;  2WDD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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