4H1YP

Human ecto-5'-nucleotidase (cd73): crystal form ii (open) in complex with psb11552
Total Genus 185
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
185
sequence length
524
structure length
524
Chain Sequence
PWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANISASGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHADEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTSCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords 5'-nucleotidase
publication title Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling.
pubmed doi rcsb
source organism Homo sapiens
total genus 185
structure length 524
sequence length 524
ec nomenclature ec 3.1.3.5: 5'-nucleotidase.
pdb deposition date 2012-09-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
P PF00149 Metallophos Calcineurin-like phosphoesterase
P PF02872 5_nucleotid_C 5'-nucleotidase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4h1yP01
3.90.780.10 Alpha Beta Alpha-Beta Complex 5'-nucleotidase; domain 2 5'-Nucleotidase, C-terminal domain 4h1yP02
2NXFA 1S95A 4TUGA 1HP1A 2YVTA 4O4KA 1G5BA 1OIDA 1XM7A 3ICFA 4FBKA 3TGHA 4UT3B 5DNYA 3E7BA 4NZVA 3IB8A 4TUIA 1S3MA 2XMOA 1T70A 2QJCA 1S70A 4H2BA 4DSYA 3N5UA 3H61A 4ORCA 3H64A 3DW8C 3RQZA 4FBWA 4H2FA 3AUZA 3ZU0A 1HO5A 4Q7FA 4LU9A 1SU1A 3EGHA 1T71A 4IL1A 2QFPA 3QFKA 4H2IA 1V73A 5J28A 1JK7A 1Z2WA 3C9FA 4B2OA 4UT3A 1AUIA 1IT6A 2WDDA 2A22A 5JPEA 2BCDA 2P6BA 2R17A 3FGAC 2AHDA 2JOGA 3C5WC 4ORBA 5EQVA 2NPPC 1TCOA 2Z72A 4H1YP 4KKZA 3K7WC 4HD0A 1U32A 1HPUA 1WAO1 3H69A 3THOB 3IVDA 4YKEA 1UTEA 4G9JA 4M0VA 3DSCA 4JA7A 4H1SA 2HY1A 4LTYA 5GTUA 4MOVA 2CV9A 2DFJA 3PSNA 3RL3A 3H60A 4I5LC 4MP0A 5INBA 4V0XA 4LACC 3PSOA 4DT2A 1II7A 2Z1AA 3H66A 4ZX2A 2O8GA 2NYMC 5B8IA 1OI8A 2IAEC 3JYFA 4V0WA 4H2GA 4UWQA 2O8AA 3IB7A 1Z2XA 1M63A 3E7AA 3QFOA 4ORAA 2HYOA 3RL5A 2WDFA 4ZVZA 4I5NC 4DHLA 5F3WA 3QFMA 1S3NA 1QHWA 1USHA 4MOYA 4FCXA 4OR9A 1NNWA 5JJTA 2IE3C 4FBQA 2Q8UA 5C1VA 1FJMA 4J6OA 2BDXA 3HVQA 3H67A 2NYLC 3P71C 5JPFA 2Z06A 2GJUA 2KKNA 4XPNA 2ZBMA 3H68A 1MF8A 4JA9A 1OIEA 4V0VA 5HPEA 3LL8A 1XZWA 1QFCA 2WDEA 4KBPA 4IYPC 1UF3A 4F0ZA 1W24A 3H63A 3DSDA 4O24A 3AV0A 2BQ8X 1S3LA 2USHA 4UT2A 3IVEA 2IE4C 3KBPA 3CK2A 3THNA 3K7VC 1KBPA 2WDCA 2QFRA 4O43A 3ZTVA 4WWLA 4O5GA 3EGGA 3QFNA 3H62B 1S8EA 5IOHA 2HYPA 3T1IA 3QG5C 3V4YA 3GVEA 3RL4A 1WARA
chains in the Genus database with same CATH superfamily
2NXFA 1S95A 3D03A 1HP1A 4TUGA 2YVTA 4O4KA 1G5BA 1OIDA 1XM7A 3ICFA 4FBKA 3TGHA 4UT3B 5DNYA 3E7BA 4NZVA 3IB8A 4TUIA 1S3MA 2XMOA 1T70A 2QJCA 1S70A 4H2BA 4DSYA 3N5UA 3H61A 4ORCA 3H64A 3DW8C 3RQZA 4FBWA 4H2FA 3AUZA 3ZU0A 1HO5A 4Q7FA 4LU9A 1SU1A 3EGHA 1T71A 4IL1A 2QFPA 3QFKA 4H2IA 1V73A 5J28A 1JK7A 1Z2WA 3C9FA 4B2OA 4UT3A 1AUIA 1IT6A 2WDDA 2A22A 5JPEA 2BCDA 2P6BA 2R17A 3FGAC 2AHDA 2JOGA 3FLOA 3C5WC 4ORBA 5EQVA 2NPPC 1TCOA 2YEQA 2Z72A 4H1YP 4KKZA 3K7WC 4HD0A 1U32A 1HPUA 1WAO1 3H69A 3THOB 3IVDA 4YKEA 1UTEA 4G9JA 4M0VA 3DSCA 3E0JA 4JA7A 4H1SA 2DXLA 2HY1A 4LTYA 5GTUA 4MOVA 2CV9A 2DFJA 3PSNA 3RL3A 3H60A 4I5LC 4MP0A 5INBA 4V0XA 4LACC 3PSOA 4DT2A 1II7A 2Z1AA 3H66A 4ZX2A 2O8GA 2NYMC 5B8IA 1OI8A 2IAEC 2ZOAA 3JYFA 4V0WA 4H2GA 2ZO9B 4UWQA 2O8AA 3IB7A 1Z2XA 1M63A 3E7AA 3QFOA 4ORAA 2HYOA 3RL5A 2WDFA 4ZVZA 4I5NC 4DHLA 5F3WA 3QFMA 1S3NA 1QHWA 1USHA 4MOYA 4FCXA 4OR9A 1NNWA 5JJTA 2IE3C 4FBQA 2Q8UA 5C1VA 1FJMA 4J6OA 2BDXA 2DXNA 3H67A 2NYLC 3HVQA 3P71C 2Z06A 2GJUA 5JPFA 2KKNA 4XPNA 2ZBMA 3H68A 1MF8A 4JA9A 1OIEA 4V0VA 5HPEA 3LL8A 1XZWA 1QFCA 2WDEA 4KBPA 4IYPC 1UF3A 4F0ZA 1W24A 3H63A 3DSDA 4O24A 3AV0A 2BQ8X 1S3LA 2USHA 4UT2A 3IVEA 2IE4C 3KBPA 3CK2A 3THNA 3K7VC 1KBPA 2WDCA 2QFRA 4O43A 3ZTVA 4WWLA 4O5GA 3EGGA 3QFNA 3H62B 1S8EA 5IOHA 2HYPA 3T1IA 3QG5C 3V4YA 3GVEA 3RL4A 1WARA
chains in the Genus database with same CATH topology
2NXFA 1S95A 3D03A 1HP1A 4TUGA 2YVTA 4O4KA 1G5BA 1OIDA 1XM7A 3ICFA 4FBKA 3TGHA 4UT3B 5DNYA 3E7BA 4NZVA 3IB8A 4TUIA 1S3MA 2XMOA 1T70A 2QJCA 1S70A 4H2BA 4DSYA 3N5UA 3H61A 4ORCA 3H64A 3DW8C 3RQZA 4FBWA 4H2FA 3AUZA 3ZU0A 1HO5A 4Q7FA 4LU9A 1SU1A 3EGHA 1T71A 4IL1A 2QFPA 3QFKA 4H2IA 1V73A 5J28A 1JK7A 1Z2WA 3C9FA 4B2OA 4UT3A 1AUIA 1IT6A 2WDDA 2A22A 5JPEA 2BCDA 2P6BA 2R17A 3FGAC 2AHDA 2JOGA 3FLOA 3C5WC 4ORBA 5EQVA 2NPPC 1TCOA 2YEQA 2Z72A 4H1YP 4KKZA 3K7WC 4HD0A 1U32A 1HPUA 1WAO1 3H69A 3THOB 3IVDA 4YKEA 1UTEA 4G9JA 4M0VA 3DSCA 3E0JA 4JA7A 4H1SA 2DXLA 2HY1A 4LTYA 5GTUA 4MOVA 2CV9A 2DFJA 3PSNA 3RL3A 3H60A 4I5LC 4MP0A 5INBA 4V0XA 4LACC 3PSOA 4DT2A 1II7A 2Z1AA 3H66A 4ZX2A 2O8GA 2NYMC 5B8IA 1OI8A 2IAEC 2ZOAA 3JYFA 4V0WA 4H2GA 2ZO9B 4UWQA 2O8AA 3IB7A 1Z2XA 1M63A 3E7AA 3QFOA 4ORAA 2HYOA 3RL5A 2WDFA 4ZVZA 4I5NC 4DHLA 5F3WA 3QFMA 1S3NA 1QHWA 1USHA 4MOYA 4FCXA 4OR9A 1NNWA 5JJTA 2IE3C 4FBQA 2Q8UA 5C1VA 1FJMA 4J6OA 2BDXA 2DXNA 3H67A 2NYLC 3HVQA 3P71C 2Z06A 2GJUA 5JPFA 2KKNA 4XPNA 2ZBMA 3H68A 1MF8A 4JA9A 1OIEA 4V0VA 5HPEA 3LL8A 1XZWA 1QFCA 2WDEA 4KBPA 4IYPC 1UF3A 4F0ZA 1W24A 3H63A 3DSDA 4O24A 3AV0A 2BQ8X 1S3LA 2USHA 4UT2A 3IVEA 2IE4C 3KBPA 3CK2A 3THNA 3K7VC 1KBPA 2WDCA 2QFRA 4O43A 3ZTVA 4WWLA 4O5GA 3EGGA 3QFNA 3H62B 1S8EA 5IOHA 2HYPA 3T1IA 3QG5C 3V4YA 3GVEA 3RL4A 1WARA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NXF A;  1S95 A;  4TUG A;  1HP1 A;  2YVT A;  4O4K A;  1G5B A;  1OID A;  1XM7 A;  3ICF A;  4FBK A;  3TGH A;  4UT3 B;  5DNY A;  3E7B A;  4NZV A;  3IB8 A;  4TUI A;  1S3M A;  2XMO A;  1T70 A;  2QJC A;  1S70 A;  4H2B A;  4DSY A;  3N5U A;  3H61 A;  4ORC A;  3H64 A;  3DW8 C;  3RQZ A;  4FBW A;  4H2F A;  3AUZ A;  3ZU0 A;  1HO5 A;  4Q7F A;  4LU9 A;  1SU1 A;  3EGH A;  1T71 A;  4IL1 A;  2QFP A;  3QFK A;  4H2I A;  1V73 A;  5J28 A;  1JK7 A;  1Z2W A;  3C9F A;  4B2O A;  4UT3 A;  1AUI A;  1IT6 A;  2WDD A;  2A22 A;  5JPE A;  2BCD A;  2P6B A;  2R17 A;  3FGA C;  2AHD A;  2JOG A;  3C5W C;  4ORB A;  5EQV A;  2NPP C;  1TCO A;  2Z72 A;  4H1Y P;  4KKZ A;  3K7W C;  4HD0 A;  1U32 A;  1HPU A;  1WAO 1;  3H69 A;  3THO B;  3IVD A;  4YKE A;  1UTE A;  4G9J A;  4M0V A;  3DSC A;  4JA7 A;  4H1S A;  2HY1 A;  4LTY A;  5GTU A;  4MOV A;  2CV9 A;  2DFJ A;  3PSN A;  3RL3 A;  3H60 A;  4I5L C;  4MP0 A;  5INB A;  4V0X A;  4LAC C;  3PSO A;  4DT2 A;  1II7 A;  2Z1A A;  3H66 A;  4ZX2 A;  2O8G A;  2NYM C;  5B8I A;  1OI8 A;  2IAE C;  3JYF A;  4V0W A;  4H2G A;  4UWQ A;  2O8A A;  3IB7 A;  1Z2X A;  1M63 A;  3E7A A;  3QFO A;  4ORA A;  2HYO A;  3RL5 A;  2WDF A;  4ZVZ A;  4I5N C;  4DHL A;  5F3W A;  3QFM A;  1S3N A;  1QHW A;  1USH A;  4MOY A;  4FCX A;  4OR9 A;  1NNW A;  5JJT A;  2IE3 C;  4FBQ A;  2Q8U A;  5C1V A;  1FJM A;  4J6O A;  2BDX A;  3HVQ A;  3H67 A;  2NYL C;  3P71 C;  5JPF A;  2Z06 A;  2GJU A;  2KKN A;  4XPN A;  2ZBM A;  3H68 A;  1MF8 A;  4JA9 A;  1OIE A;  4V0V A;  5HPE A;  3LL8 A;  1XZW A;  1QFC A;  2WDE A;  4KBP A;  4IYP C;  1UF3 A;  4F0Z A;  1W24 A;  3H63 A;  3DSD A;  4O24 A;  3AV0 A;  2BQ8 X;  1S3L A;  2USH A;  4UT2 A;  3IVE A;  2IE4 C;  3KBP A;  3CK2 A;  3THN A;  3K7V C;  1KBP A;  2WDC A;  2QFR A;  4O43 A;  3ZTV A;  4WWL A;  4O5G A;  3EGG A;  3QFN A;  3H62 B;  1S8E A;  5IOH A;  2HYP A;  3T1I A;  3QG5 C;  3V4Y A;  3GVE A;  3RL4 A;  1WAR A; 
#chains in the Genus database with same CATH topology
 2NXF A;  1S95 A;  3D03 A;  1HP1 A;  4TUG A;  2YVT A;  4O4K A;  1G5B A;  1OID A;  1XM7 A;  3ICF A;  4FBK A;  3TGH A;  4UT3 B;  5DNY A;  3E7B A;  4NZV A;  3IB8 A;  4TUI A;  1S3M A;  2XMO A;  1T70 A;  2QJC A;  1S70 A;  4H2B A;  4DSY A;  3N5U A;  3H61 A;  4ORC A;  3H64 A;  3DW8 C;  3RQZ A;  4FBW A;  4H2F A;  3AUZ A;  3ZU0 A;  1HO5 A;  4Q7F A;  4LU9 A;  1SU1 A;  3EGH A;  1T71 A;  4IL1 A;  2QFP A;  3QFK A;  4H2I A;  1V73 A;  5J28 A;  1JK7 A;  1Z2W A;  3C9F A;  4B2O A;  4UT3 A;  1AUI A;  1IT6 A;  2WDD A;  2A22 A;  5JPE A;  2BCD A;  2P6B A;  2R17 A;  3FGA C;  2AHD A;  2JOG A;  3FLO A;  3C5W C;  4ORB A;  5EQV A;  2NPP C;  1TCO A;  2YEQ A;  2Z72 A;  4H1Y P;  4KKZ A;  3K7W C;  4HD0 A;  1U32 A;  1HPU A;  1WAO 1;  3H69 A;  3THO B;  3IVD A;  4YKE A;  1UTE A;  4G9J A;  4M0V A;  3DSC A;  3E0J A;  4JA7 A;  4H1S A;  2DXL A;  2HY1 A;  4LTY A;  5GTU A;  4MOV A;  2CV9 A;  2DFJ A;  3PSN A;  3RL3 A;  3H60 A;  4I5L C;  4MP0 A;  5INB A;  4V0X A;  4LAC C;  3PSO A;  4DT2 A;  1II7 A;  2Z1A A;  3H66 A;  4ZX2 A;  2O8G A;  2NYM C;  5B8I A;  1OI8 A;  2IAE C;  2ZOA A;  3JYF A;  4V0W A;  4H2G A;  2ZO9 B;  4UWQ A;  2O8A A;  3IB7 A;  1Z2X A;  1M63 A;  3E7A A;  3QFO A;  4ORA A;  2HYO A;  3RL5 A;  2WDF A;  4ZVZ A;  4I5N C;  4DHL A;  5F3W A;  3QFM A;  1S3N A;  1QHW A;  1USH A;  4MOY A;  4FCX A;  4OR9 A;  1NNW A;  5JJT A;  2IE3 C;  4FBQ A;  2Q8U A;  5C1V A;  1FJM A;  4J6O A;  2BDX A;  2DXN A;  3H67 A;  2NYL C;  3HVQ A;  3P71 C;  2Z06 A;  2GJU A;  5JPF A;  2KKN A;  4XPN A;  2ZBM A;  3H68 A;  1MF8 A;  4JA9 A;  1OIE A;  4V0V A;  5HPE A;  3LL8 A;  1XZW A;  1QFC A;  2WDE A;  4KBP A;  4IYP C;  1UF3 A;  4F0Z A;  1W24 A;  3H63 A;  3DSD A;  4O24 A;  3AV0 A;  2BQ8 X;  1S3L A;  2USH A;  4UT2 A;  3IVE A;  2IE4 C;  3KBP A;  3CK2 A;  3THN A;  3K7V C;  1KBP A;  2WDC A;  2QFR A;  4O43 A;  3ZTV A;  4WWL A;  4O5G A;  3EGG A;  3QFN A;  3H62 B;  1S8E A;  5IOH A;  2HYP A;  3T1I A;  3QG5 C;  3V4Y A;  3GVE A;  3RL4 A;  1WAR A; 
#chains in the Genus database with same CATH homology
 2NXF A;  1S95 A;  3D03 A;  1HP1 A;  4TUG A;  2YVT A;  4O4K A;  1G5B A;  1OID A;  1XM7 A;  3ICF A;  4FBK A;  3TGH A;  4UT3 B;  5DNY A;  3E7B A;  4NZV A;  3IB8 A;  4TUI A;  1S3M A;  2XMO A;  1T70 A;  2QJC A;  1S70 A;  4H2B A;  4DSY A;  3N5U A;  3H61 A;  4ORC A;  3H64 A;  3DW8 C;  3RQZ A;  4FBW A;  4H2F A;  3AUZ A;  3ZU0 A;  1HO5 A;  4Q7F A;  4LU9 A;  1SU1 A;  3EGH A;  1T71 A;  4IL1 A;  2QFP A;  3QFK A;  4H2I A;  1V73 A;  5J28 A;  1JK7 A;  1Z2W A;  3C9F A;  4B2O A;  4UT3 A;  1AUI A;  1IT6 A;  2WDD A;  2A22 A;  5JPE A;  2BCD A;  2P6B A;  2R17 A;  3FGA C;  2AHD A;  2JOG A;  3FLO A;  3C5W C;  4ORB A;  5EQV A;  2NPP C;  1TCO A;  2YEQ A;  2Z72 A;  4H1Y P;  4KKZ A;  3K7W C;  4HD0 A;  1U32 A;  1HPU A;  1WAO 1;  3H69 A;  3THO B;  3IVD A;  4YKE A;  1UTE A;  4G9J A;  4M0V A;  3DSC A;  3E0J A;  4JA7 A;  4H1S A;  2DXL A;  2HY1 A;  4LTY A;  5GTU A;  4MOV A;  2CV9 A;  2DFJ A;  3PSN A;  3RL3 A;  3H60 A;  4I5L C;  4MP0 A;  5INB A;  4V0X A;  4LAC C;  3PSO A;  4DT2 A;  1II7 A;  2Z1A A;  3H66 A;  4ZX2 A;  2O8G A;  2NYM C;  5B8I A;  1OI8 A;  2IAE C;  2ZOA A;  3JYF A;  4V0W A;  4H2G A;  2ZO9 B;  4UWQ A;  2O8A A;  3IB7 A;  1Z2X A;  1M63 A;  3E7A A;  3QFO A;  4ORA A;  2HYO A;  3RL5 A;  2WDF A;  4ZVZ A;  4I5N C;  4DHL A;  5F3W A;  3QFM A;  1S3N A;  1QHW A;  1USH A;  4MOY A;  4FCX A;  4OR9 A;  1NNW A;  5JJT A;  2IE3 C;  4FBQ A;  2Q8U A;  5C1V A;  1FJM A;  4J6O A;  2BDX A;  2DXN A;  3H67 A;  2NYL C;  3HVQ A;  3P71 C;  2Z06 A;  2GJU A;  5JPF A;  2KKN A;  4XPN A;  2ZBM A;  3H68 A;  1MF8 A;  4JA9 A;  1OIE A;  4V0V A;  5HPE A;  3LL8 A;  1XZW A;  1QFC A;  2WDE A;  4KBP A;  4IYP C;  1UF3 A;  4F0Z A;  1W24 A;  3H63 A;  3DSD A;  4O24 A;  3AV0 A;  2BQ8 X;  1S3L A;  2USH A;  4UT2 A;  3IVE A;  2IE4 C;  3KBP A;  3CK2 A;  3THN A;  3K7V C;  1KBP A;  2WDC A;  2QFR A;  4O43 A;  3ZTV A;  4WWL A;  4O5G A;  3EGG A;  3QFN A;  3H62 B;  1S8E A;  5IOH A;  2HYP A;  3T1I A;  3QG5 C;  3V4Y A;  3GVE A;  3RL4 A;  1WAR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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