1U32A

Crystal structure of a protein phosphatase-1: calcineurin hybrid bound to okadaic acid
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
293
structure length
293
Chain Sequence
KLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYLDVYNNAGAMMSVDETLMCSFQILKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure and Mutagenesis of a Protein Phosphatase-1:Calcineurin Hybrid Elucidate the Role of the {beta}12-{beta}13 Loop in Inhibitor Binding
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Serine/threonine protein phosphatase PP1-gamma catalytic sub
total genus 106
structure length 293
sequence length 293
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2004-07-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF16891 STPPase_N Serine-threonine protein phosphatase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 1u32A00
1S3NA 3CK2A 5JPFA 5F3WA 1WAO1 3H64A 5JPEA 2CV9A 1V73A 4O5GA 3N5UA 2HY1A 4H1YP 2AHDA 3QFMA 3C9FA 3H66A 2O8AA 3E7BA 4I5NC 2ZBMA 4MOYA 4H2FA 2NYLC 4OR9A 3EGHA 4V0XA 4LACC 4MP0A 5IOHA 4IYPC 2Z72A 3AUZA 1U32A 4MOVA 2HYOA 3TGHA 3IB7A 4KBPA 2Z1AA 2Q8UA 4H2BA 1WARA 1G5BA 3RL4A 4DT2A 4UT3B 4B2OA 2WDEA 4FBKA 3V4YA 4O24A 1S8EA 3H69A 1FJMA 4FBWA 1T71A 4ORCA 5J28A 1OI8A 4O43A 2QFPA 1HPUA 3PSOA 3RL5A 3HVQA 4TUGA 2GJUA 1Z2XA 3H63A 2WDFA 3THNA 1UTEA 3H62B 5EQVA 1OIEA 1UF3A 4H2IA 3THOB 5DNYA 4Q7FA 4DSYA 2WDDA 2QFRA 4WWLA 4ZVZA 4LU9A 4V0WA 4F0ZA 2WDCA 4JA7A 4YKEA 2BQ8X 3RQZA 3QG5C 3PSNA 1KBPA 4M0VA 2QJCA 1S3MA 3DW8C 1AUIA 3H60A 1SU1A 5GTUA 1HO5A 4NZVA 3H67A 4H2GA 1Z2WA 5INBA 4JA9A 4H1SA 2JOGA 2KKNA 3H61A 2DFJA 3FGAC 4ORAA 3KBPA 3IVEA 4HD0A 3H68A 3JYFA 3ZTVA 2Z06A 2XMOA 4J6OA 2R17A 5JJTA 1S70A 3E7AA 2USHA 5HPEA 3IB8A 4UT2A 4UT3A 1HP1A 3QFKA 1II7A 5C1VA 4LTYA 3QFOA 3EGGA 1MF8A 3DSCA 1XZWA 3C5WC 4FBQA 3ZU0A 2YVTA 4UWQA 4ZX2A 1JK7A 1TCOA 2O8GA 4O4KA 5B8IA 1S95A 3P71C 4IL1A 2A22A 1W24A 2IE3C 3IVDA 2IAEC 4DHLA 2IE4C 3ICFA 4XPNA 3K7VC 2BDXA 1USHA 4TUIA 1M63A 4V0VA 1OIDA 2HYPA 1NNWA 1XM7A 1QHWA 2NXFA 2NYMC 4FCXA 2P6BA 3K7WC 1IT6A 3T1IA 4G9JA 4KKZA 1S3LA 4I5LC 1QFCA 3RL3A 2NPPC 3AV0A 3LL8A 1T70A 3GVEA 3QFNA 3DSDA 2BCDA 4ORBA
chains in the Genus database with same CATH superfamily
1S3NA 3CK2A 5JPFA 5F3WA 2ZO9B 1WAO1 2DXNA 3H64A 5JPEA 2CV9A 1V73A 4O5GA 3N5UA 2HY1A 4H1YP 2AHDA 3QFMA 3C9FA 3H66A 2O8AA 3E7BA 4I5NC 2ZBMA 4MOYA 4H2FA 2NYLC 4OR9A 3EGHA 4V0XA 4LACC 4MP0A 5IOHA 4IYPC 2Z72A 3AUZA 1U32A 4MOVA 2HYOA 3TGHA 3IB7A 4KBPA 2Z1AA 2Q8UA 4H2BA 1WARA 1G5BA 3RL4A 4DT2A 4UT3B 4B2OA 2WDEA 4FBKA 3V4YA 4O24A 1S8EA 3H69A 1FJMA 4FBWA 1T71A 4ORCA 5J28A 1OI8A 4O43A 2QFPA 1HPUA 3PSOA 3RL5A 3FLOA 3HVQA 4TUGA 2GJUA 1Z2XA 3H63A 2WDFA 3THNA 1UTEA 3H62B 5EQVA 1OIEA 1UF3A 4H2IA 3THOB 5DNYA 4Q7FA 4DSYA 2WDDA 2QFRA 4WWLA 4ZVZA 4LU9A 4V0WA 4F0ZA 2WDCA 3D03A 4JA7A 4YKEA 2BQ8X 3RQZA 3QG5C 3PSNA 1KBPA 4M0VA 2QJCA 1S3MA 3DW8C 1AUIA 3H60A 1SU1A 5GTUA 1HO5A 4NZVA 3H67A 4H2GA 1Z2WA 5INBA 4JA9A 4H1SA 2JOGA 2KKNA 3H61A 2DFJA 3FGAC 4ORAA 3KBPA 3IVEA 4HD0A 3H68A 3JYFA 3ZTVA 2Z06A 2XMOA 2DXLA 4J6OA 2R17A 5JJTA 1S70A 3E7AA 2YEQA 2USHA 5HPEA 3IB8A 4UT2A 4UT3A 1HP1A 3QFKA 1II7A 5C1VA 4LTYA 3QFOA 3EGGA 1MF8A 3DSCA 1XZWA 3C5WC 4FBQA 3ZU0A 2YVTA 4UWQA 4ZX2A 1JK7A 1TCOA 2O8GA 4O4KA 5B8IA 1S95A 3P71C 4IL1A 2A22A 1W24A 2IE3C 3IVDA 2IAEC 4DHLA 2IE4C 3ICFA 4XPNA 3K7VC 2BDXA 1USHA 4TUIA 1M63A 4V0VA 1OIDA 2HYPA 1NNWA 1XM7A 1QHWA 2NXFA 2NYMC 4FCXA 2P6BA 3K7WC 1IT6A 3E0JA 4G9JA 3T1IA 4KKZA 1S3LA 2ZOAA 4I5LC 1QFCA 3RL3A 2NPPC 3AV0A 3LL8A 1T70A 3GVEA 3QFNA 3DSDA 2BCDA 4ORBA
chains in the Genus database with same CATH topology
1S3NA 3CK2A 5JPFA 5F3WA 2ZO9B 1WAO1 2DXNA 3H64A 5JPEA 2CV9A 1V73A 4O5GA 3N5UA 2HY1A 4H1YP 2AHDA 3QFMA 3C9FA 3H66A 2O8AA 3E7BA 4I5NC 2ZBMA 4MOYA 4H2FA 2NYLC 4OR9A 3EGHA 4V0XA 4LACC 4MP0A 5IOHA 4IYPC 2Z72A 3AUZA 1U32A 4MOVA 2HYOA 3TGHA 3IB7A 4KBPA 2Z1AA 2Q8UA 4H2BA 1WARA 1G5BA 3RL4A 4DT2A 4UT3B 4B2OA 2WDEA 4FBKA 3V4YA 4O24A 1S8EA 3H69A 1FJMA 4FBWA 1T71A 4ORCA 5J28A 1OI8A 4O43A 2QFPA 1HPUA 3PSOA 3RL5A 3FLOA 3HVQA 4TUGA 2GJUA 1Z2XA 3H63A 2WDFA 3THNA 1UTEA 3H62B 5EQVA 1OIEA 1UF3A 4H2IA 3THOB 5DNYA 4Q7FA 4DSYA 2WDDA 2QFRA 4WWLA 4ZVZA 4LU9A 4V0WA 4F0ZA 2WDCA 3D03A 4JA7A 4YKEA 2BQ8X 3RQZA 3QG5C 3PSNA 1KBPA 4M0VA 2QJCA 1S3MA 3DW8C 1AUIA 3H60A 1SU1A 5GTUA 1HO5A 4NZVA 3H67A 4H2GA 1Z2WA 5INBA 4JA9A 4H1SA 2JOGA 2KKNA 3H61A 2DFJA 3FGAC 4ORAA 3KBPA 3IVEA 4HD0A 3H68A 3JYFA 3ZTVA 2Z06A 2XMOA 2DXLA 4J6OA 2R17A 5JJTA 1S70A 3E7AA 2YEQA 2USHA 5HPEA 3IB8A 4UT2A 4UT3A 1HP1A 3QFKA 1II7A 5C1VA 4LTYA 3QFOA 3EGGA 1MF8A 3DSCA 1XZWA 3C5WC 4FBQA 3ZU0A 2YVTA 4UWQA 4ZX2A 1JK7A 1TCOA 2O8GA 4O4KA 5B8IA 1S95A 3P71C 4IL1A 2A22A 1W24A 2IE3C 3IVDA 2IAEC 4DHLA 2IE4C 3ICFA 4XPNA 3K7VC 2BDXA 1USHA 4TUIA 1M63A 4V0VA 1OIDA 2HYPA 1NNWA 1XM7A 1QHWA 2NXFA 2NYMC 4FCXA 2P6BA 3K7WC 1IT6A 3E0JA 4G9JA 3T1IA 4KKZA 1S3LA 2ZOAA 4I5LC 1QFCA 3RL3A 2NPPC 3AV0A 3LL8A 1T70A 3GVEA 3QFNA 3DSDA 2BCDA 4ORBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1S3N A;  3CK2 A;  5JPF A;  5F3W A;  1WAO 1;  3H64 A;  5JPE A;  2CV9 A;  1V73 A;  4O5G A;  3N5U A;  2HY1 A;  4H1Y P;  2AHD A;  3QFM A;  3C9F A;  3H66 A;  2O8A A;  3E7B A;  4I5N C;  2ZBM A;  4MOY A;  4H2F A;  2NYL C;  4OR9 A;  3EGH A;  4V0X A;  4LAC C;  4MP0 A;  5IOH A;  4IYP C;  2Z72 A;  3AUZ A;  1U32 A;  4MOV A;  2HYO A;  3TGH A;  3IB7 A;  4KBP A;  2Z1A A;  2Q8U A;  4H2B A;  1WAR A;  1G5B A;  3RL4 A;  4DT2 A;  4UT3 B;  4B2O A;  2WDE A;  4FBK A;  3V4Y A;  4O24 A;  1S8E A;  3H69 A;  1FJM A;  4FBW A;  1T71 A;  4ORC A;  5J28 A;  1OI8 A;  4O43 A;  2QFP A;  1HPU A;  3PSO A;  3RL5 A;  3HVQ A;  4TUG A;  2GJU A;  1Z2X A;  3H63 A;  2WDF A;  3THN A;  1UTE A;  3H62 B;  5EQV A;  1OIE A;  1UF3 A;  4H2I A;  3THO B;  5DNY A;  4Q7F A;  4DSY A;  2WDD A;  2QFR A;  4WWL A;  4ZVZ A;  4LU9 A;  4V0W A;  4F0Z A;  2WDC A;  4JA7 A;  4YKE A;  2BQ8 X;  3RQZ A;  3QG5 C;  3PSN A;  1KBP A;  4M0V A;  2QJC A;  1S3M A;  3DW8 C;  1AUI A;  3H60 A;  1SU1 A;  5GTU A;  1HO5 A;  4NZV A;  3H67 A;  4H2G A;  1Z2W A;  5INB A;  4JA9 A;  4H1S A;  2JOG A;  2KKN A;  3H61 A;  2DFJ A;  3FGA C;  4ORA A;  3KBP A;  3IVE A;  4HD0 A;  3H68 A;  3JYF A;  3ZTV A;  2Z06 A;  2XMO A;  4J6O A;  2R17 A;  5JJT A;  1S70 A;  3E7A A;  2USH A;  5HPE A;  3IB8 A;  4UT2 A;  4UT3 A;  1HP1 A;  3QFK A;  1II7 A;  5C1V A;  4LTY A;  3QFO A;  3EGG A;  1MF8 A;  3DSC A;  1XZW A;  3C5W C;  4FBQ A;  3ZU0 A;  2YVT A;  4UWQ A;  4ZX2 A;  1JK7 A;  1TCO A;  2O8G A;  4O4K A;  5B8I A;  1S95 A;  3P71 C;  4IL1 A;  2A22 A;  1W24 A;  2IE3 C;  3IVD A;  2IAE C;  4DHL A;  2IE4 C;  3ICF A;  4XPN A;  3K7V C;  2BDX A;  1USH A;  4TUI A;  1M63 A;  4V0V A;  1OID A;  2HYP A;  1NNW A;  1XM7 A;  1QHW A;  2NXF A;  2NYM C;  4FCX A;  2P6B A;  3K7W C;  1IT6 A;  3T1I A;  4G9J A;  4KKZ A;  1S3L A;  4I5L C;  1QFC A;  3RL3 A;  2NPP C;  3AV0 A;  3LL8 A;  1T70 A;  3GVE A;  3QFN A;  3DSD A;  2BCD A;  4ORB A; 
#chains in the Genus database with same CATH topology
 1S3N A;  3CK2 A;  5JPF A;  5F3W A;  2ZO9 B;  1WAO 1;  2DXN A;  3H64 A;  5JPE A;  2CV9 A;  1V73 A;  4O5G A;  3N5U A;  2HY1 A;  4H1Y P;  2AHD A;  3QFM A;  3C9F A;  3H66 A;  2O8A A;  3E7B A;  4I5N C;  2ZBM A;  4MOY A;  4H2F A;  2NYL C;  4OR9 A;  3EGH A;  4V0X A;  4LAC C;  4MP0 A;  5IOH A;  4IYP C;  2Z72 A;  3AUZ A;  1U32 A;  4MOV A;  2HYO A;  3TGH A;  3IB7 A;  4KBP A;  2Z1A A;  2Q8U A;  4H2B A;  1WAR A;  1G5B A;  3RL4 A;  4DT2 A;  4UT3 B;  4B2O A;  2WDE A;  4FBK A;  3V4Y A;  4O24 A;  1S8E A;  3H69 A;  1FJM A;  4FBW A;  1T71 A;  4ORC A;  5J28 A;  1OI8 A;  4O43 A;  2QFP A;  1HPU A;  3PSO A;  3RL5 A;  3FLO A;  3HVQ A;  4TUG A;  2GJU A;  1Z2X A;  3H63 A;  2WDF A;  3THN A;  1UTE A;  3H62 B;  5EQV A;  1OIE A;  1UF3 A;  4H2I A;  3THO B;  5DNY A;  4Q7F A;  4DSY A;  2WDD A;  2QFR A;  4WWL A;  4ZVZ A;  4LU9 A;  4V0W A;  4F0Z A;  2WDC A;  3D03 A;  4JA7 A;  4YKE A;  2BQ8 X;  3RQZ A;  3QG5 C;  3PSN A;  1KBP A;  4M0V A;  2QJC A;  1S3M A;  3DW8 C;  1AUI A;  3H60 A;  1SU1 A;  5GTU A;  1HO5 A;  4NZV A;  3H67 A;  4H2G A;  1Z2W A;  5INB A;  4JA9 A;  4H1S A;  2JOG A;  2KKN A;  3H61 A;  2DFJ A;  3FGA C;  4ORA A;  3KBP A;  3IVE A;  4HD0 A;  3H68 A;  3JYF A;  3ZTV A;  2Z06 A;  2XMO A;  2DXL A;  4J6O A;  2R17 A;  5JJT A;  1S70 A;  3E7A A;  2YEQ A;  2USH A;  5HPE A;  3IB8 A;  4UT2 A;  4UT3 A;  1HP1 A;  3QFK A;  1II7 A;  5C1V A;  4LTY A;  3QFO A;  3EGG A;  1MF8 A;  3DSC A;  1XZW A;  3C5W C;  4FBQ A;  3ZU0 A;  2YVT A;  4UWQ A;  4ZX2 A;  1JK7 A;  1TCO A;  2O8G A;  4O4K A;  5B8I A;  1S95 A;  3P71 C;  4IL1 A;  2A22 A;  1W24 A;  2IE3 C;  3IVD A;  2IAE C;  4DHL A;  2IE4 C;  3ICF A;  4XPN A;  3K7V C;  2BDX A;  1USH A;  4TUI A;  1M63 A;  4V0V A;  1OID A;  2HYP A;  1NNW A;  1XM7 A;  1QHW A;  2NXF A;  2NYM C;  4FCX A;  2P6B A;  3K7W C;  1IT6 A;  3E0J A;  4G9J A;  3T1I A;  4KKZ A;  1S3L A;  2ZOA A;  4I5L C;  1QFC A;  3RL3 A;  2NPP C;  3AV0 A;  3LL8 A;  1T70 A;  3GVE A;  3QFN A;  3DSD A;  2BCD A;  4ORB A; 
#chains in the Genus database with same CATH homology
 1S3N A;  3CK2 A;  5JPF A;  5F3W A;  2ZO9 B;  1WAO 1;  2DXN A;  3H64 A;  5JPE A;  2CV9 A;  1V73 A;  4O5G A;  3N5U A;  2HY1 A;  4H1Y P;  2AHD A;  3QFM A;  3C9F A;  3H66 A;  2O8A A;  3E7B A;  4I5N C;  2ZBM A;  4MOY A;  4H2F A;  2NYL C;  4OR9 A;  3EGH A;  4V0X A;  4LAC C;  4MP0 A;  5IOH A;  4IYP C;  2Z72 A;  3AUZ A;  1U32 A;  4MOV A;  2HYO A;  3TGH A;  3IB7 A;  4KBP A;  2Z1A A;  2Q8U A;  4H2B A;  1WAR A;  1G5B A;  3RL4 A;  4DT2 A;  4UT3 B;  4B2O A;  2WDE A;  4FBK A;  3V4Y A;  4O24 A;  1S8E A;  3H69 A;  1FJM A;  4FBW A;  1T71 A;  4ORC A;  5J28 A;  1OI8 A;  4O43 A;  2QFP A;  1HPU A;  3PSO A;  3RL5 A;  3FLO A;  3HVQ A;  4TUG A;  2GJU A;  1Z2X A;  3H63 A;  2WDF A;  3THN A;  1UTE A;  3H62 B;  5EQV A;  1OIE A;  1UF3 A;  4H2I A;  3THO B;  5DNY A;  4Q7F A;  4DSY A;  2WDD A;  2QFR A;  4WWL A;  4ZVZ A;  4LU9 A;  4V0W A;  4F0Z A;  2WDC A;  3D03 A;  4JA7 A;  4YKE A;  2BQ8 X;  3RQZ A;  3QG5 C;  3PSN A;  1KBP A;  4M0V A;  2QJC A;  1S3M A;  3DW8 C;  1AUI A;  3H60 A;  1SU1 A;  5GTU A;  1HO5 A;  4NZV A;  3H67 A;  4H2G A;  1Z2W A;  5INB A;  4JA9 A;  4H1S A;  2JOG A;  2KKN A;  3H61 A;  2DFJ A;  3FGA C;  4ORA A;  3KBP A;  3IVE A;  4HD0 A;  3H68 A;  3JYF A;  3ZTV A;  2Z06 A;  2XMO A;  2DXL A;  4J6O A;  2R17 A;  5JJT A;  1S70 A;  3E7A A;  2YEQ A;  2USH A;  5HPE A;  3IB8 A;  4UT2 A;  4UT3 A;  1HP1 A;  3QFK A;  1II7 A;  5C1V A;  4LTY A;  3QFO A;  3EGG A;  1MF8 A;  3DSC A;  1XZW A;  3C5W C;  4FBQ A;  3ZU0 A;  2YVT A;  4UWQ A;  4ZX2 A;  1JK7 A;  1TCO A;  2O8G A;  4O4K A;  5B8I A;  1S95 A;  3P71 C;  4IL1 A;  2A22 A;  1W24 A;  2IE3 C;  3IVD A;  2IAE C;  4DHL A;  2IE4 C;  3ICF A;  4XPN A;  3K7V C;  2BDX A;  1USH A;  4TUI A;  1M63 A;  4V0V A;  1OID A;  2HYP A;  1NNW A;  1XM7 A;  1QHW A;  2NXF A;  2NYM C;  4FCX A;  2P6B A;  3K7W C;  1IT6 A;  3E0J A;  4G9J A;  3T1I A;  4KKZ A;  1S3L A;  2ZOA A;  4I5L C;  1QFC A;  3RL3 A;  2NPP C;  3AV0 A;  3LL8 A;  1T70 A;  3GVE A;  3QFN A;  3DSD A;  2BCD A;  4ORB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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