2IE3C

Structure of the protein phosphatase 2a core enzyme bound to tumor-inducing toxins
Total Genus 104
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
288
structure length
288
Chain Sequence
FTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins
pubmed doi rcsb
molecule tags Hydrolase/toxin
source organism Homo sapiens
molecule keywords Protein Phosphatase 2, regulatory subunit A (PR 65), alpha i
total genus 104
structure length 288
sequence length 288
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2006-09-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2ie3C00
1AUIA 1S70A 4JA9A 2Z06A 4NZVA 3QFMA 1KBPA 1U32A 2YVTA 4LACC 2XMOA 4F0ZA 1XZWA 2O8AA 2WDCA 4UT2A 1W24A 4KKZA 3PSOA 5DNYA 3FGAC 3QG5C 1HP1A 3DSDA 3IVDA 2Z1AA 3RQZA 4FBKA 3H61A 4DSYA 4H2FA 2QFPA 1OIEA 1QHWA 2NXFA 4B2OA 4ORAA 2A22A 2P6BA 4ZX2A 2IE3C 4IYPC 2NYMC 3H63A 2NYLC 3H64A 2BDXA 2R17A 4LU9A 4G9JA 1TCOA 2HYPA 3ICFA 3IB8A 3JYFA 2CV9A 4FCXA 4TUIA 4LTYA 3IVEA 3T1IA 4H2GA 3QFKA 1II7A 1IT6A 2O8GA 4KBPA 4IL1A 1S3LA 1M63A 4MOYA 2AHDA 1WARA 1UTEA 3GVEA 2Q8UA 3PSNA 4FBQA 4OR9A 3V4YA 4DT2A 4V0VA 4H1YP 3C9FA 5IOHA 2JOGA 1OI8A 1V73A 3HVQA 2IE4C 3LL8A 4H2BA 4V0WA 4ZVZA 3TGHA 4XPNA 3H67A 3DSCA 3P71C 4FBWA 3K7WC 2ZBMA 3KBPA 4J6OA 3E7BA 5B8IA 4H1SA 1Z2XA 3H68A 3K7VC 1S8EA 3C5WC 3CK2A 5F3WA 3RL4A 3EGGA 2USHA 4ORCA 4YKEA 4ORBA 2WDDA 4UT3B 1SU1A 2KKNA 1NNWA 1S3MA 1XM7A 5JJTA 1WAO1 1G5BA 2HY1A 1FJMA 1UF3A 3AUZA 1QFCA 3H62B 3ZU0A 4O24A 1T71A 3RL3A 4O4KA 3H69A 5C1VA 1T70A 2QJCA 1JK7A 2BCDA 4V0XA 3RL5A 1OIDA 2BQ8X 3N5UA 5GTUA 3ZTVA 4TUGA 3E7AA 4UT3A 2NPPC 3QFNA 5JPFA 2GJUA 2QFRA 2Z72A 3IB7A 4H2IA 3THOB 3DW8C 1MF8A 2IAEC 4UWQA 2HYOA 3AV0A 4WWLA 2WDFA 4I5LC 5J28A 1USHA 4HD0A 2WDEA 4MP0A 4Q7FA 1HO5A 3H66A 5JPEA 4O43A 4O5GA 4JA7A 3EGHA 5EQVA 4DHLA 5INBA 3QFOA 3H60A 4I5NC 1HPUA 1S3NA 1S95A 5HPEA 1Z2WA 4MOVA 4M0VA 3THNA 2DFJA
chains in the Genus database with same CATH superfamily
1AUIA 1S70A 4JA9A 2Z06A 4NZVA 3QFMA 1KBPA 1U32A 2YVTA 4LACC 2XMOA 4F0ZA 1XZWA 2O8AA 2ZO9B 2WDCA 4UT2A 1W24A 4KKZA 3PSOA 5DNYA 3FGAC 3QG5C 1HP1A 3DSDA 3IVDA 2Z1AA 3RQZA 4FBKA 3H61A 4DSYA 4H2FA 2QFPA 1OIEA 1QHWA 2NXFA 4B2OA 4ORAA 2A22A 2P6BA 4ZX2A 2IE3C 4IYPC 2NYMC 3H63A 2NYLC 3H64A 2BDXA 2R17A 4LU9A 4G9JA 1TCOA 2HYPA 3ICFA 3IB8A 3JYFA 2CV9A 4FCXA 4TUIA 4LTYA 3IVEA 3T1IA 4H2GA 3QFKA 1II7A 1IT6A 2O8GA 4KBPA 4IL1A 1S3LA 1M63A 4MOYA 2AHDA 1WARA 1UTEA 3GVEA 2Q8UA 3PSNA 4FBQA 4OR9A 3V4YA 4DT2A 4V0VA 4H1YP 3C9FA 5IOHA 3D03A 2JOGA 1OI8A 1V73A 3HVQA 2IE4C 3LL8A 4H2BA 4V0WA 4ZVZA 3TGHA 4XPNA 2DXNA 3H67A 3DSCA 3P71C 4FBWA 3K7WC 2ZBMA 3KBPA 4J6OA 3E7BA 5B8IA 4H1SA 1Z2XA 3H68A 3K7VC 1S8EA 3C5WC 3CK2A 5F3WA 3RL4A 3EGGA 2USHA 4ORCA 4YKEA 4ORBA 2DXLA 2WDDA 3E0JA 4UT3B 1SU1A 2YEQA 2KKNA 1NNWA 1S3MA 1XM7A 5JJTA 1WAO1 1G5BA 2HY1A 1FJMA 1UF3A 3AUZA 1QFCA 3H62B 3FLOA 3ZU0A 4O24A 1T71A 3RL3A 4O4KA 3H69A 5C1VA 1T70A 2QJCA 1JK7A 2BCDA 4V0XA 3RL5A 1OIDA 2BQ8X 3N5UA 5GTUA 3ZTVA 4TUGA 3E7AA 4UT3A 2NPPC 3QFNA 5JPFA 2GJUA 2QFRA 2Z72A 3IB7A 4H2IA 3THOB 3DW8C 1MF8A 2IAEC 4UWQA 2HYOA 3AV0A 4WWLA 2WDFA 4I5LC 5J28A 1USHA 4HD0A 2WDEA 4MP0A 4Q7FA 1HO5A 3H66A 5JPEA 4O43A 4O5GA 4JA7A 3EGHA 5EQVA 4DHLA 5INBA 3QFOA 3H60A 4I5NC 1HPUA 1S3NA 1S95A 5HPEA 1Z2WA 4MOVA 4M0VA 3THNA 2DFJA 2ZOAA
chains in the Genus database with same CATH topology
1AUIA 1S70A 4JA9A 2Z06A 4NZVA 3QFMA 1KBPA 1U32A 2YVTA 4LACC 2XMOA 4F0ZA 1XZWA 2O8AA 2ZO9B 2WDCA 4UT2A 1W24A 4KKZA 3PSOA 5DNYA 3FGAC 3QG5C 1HP1A 3DSDA 3IVDA 2Z1AA 3RQZA 4FBKA 3H61A 4DSYA 4H2FA 2QFPA 1OIEA 1QHWA 2NXFA 4B2OA 4ORAA 2A22A 2P6BA 4ZX2A 2IE3C 4IYPC 2NYMC 3H63A 2NYLC 3H64A 2BDXA 2R17A 4LU9A 4G9JA 1TCOA 2HYPA 3ICFA 3IB8A 3JYFA 2CV9A 4FCXA 4TUIA 4LTYA 3IVEA 3T1IA 4H2GA 3QFKA 1II7A 1IT6A 2O8GA 4KBPA 4IL1A 1S3LA 1M63A 4MOYA 2AHDA 1WARA 1UTEA 3GVEA 2Q8UA 3PSNA 4FBQA 4OR9A 3V4YA 4DT2A 4V0VA 4H1YP 3C9FA 5IOHA 3D03A 2JOGA 1OI8A 1V73A 3HVQA 2IE4C 3LL8A 4H2BA 4V0WA 4ZVZA 3TGHA 4XPNA 2DXNA 3H67A 3DSCA 3P71C 4FBWA 3K7WC 2ZBMA 3KBPA 4J6OA 3E7BA 5B8IA 4H1SA 1Z2XA 3H68A 3K7VC 1S8EA 3C5WC 3CK2A 5F3WA 3RL4A 3EGGA 2USHA 4ORCA 4YKEA 4ORBA 2DXLA 2WDDA 3E0JA 4UT3B 1SU1A 2YEQA 2KKNA 1NNWA 1S3MA 1XM7A 5JJTA 1WAO1 1G5BA 2HY1A 1FJMA 1UF3A 3AUZA 1QFCA 3H62B 3FLOA 3ZU0A 4O24A 1T71A 3RL3A 4O4KA 3H69A 5C1VA 1T70A 2QJCA 1JK7A 2BCDA 4V0XA 3RL5A 1OIDA 2BQ8X 3N5UA 5GTUA 3ZTVA 4TUGA 3E7AA 4UT3A 2NPPC 3QFNA 5JPFA 2GJUA 2QFRA 2Z72A 3IB7A 4H2IA 3THOB 3DW8C 1MF8A 2IAEC 4UWQA 2HYOA 3AV0A 4WWLA 2WDFA 4I5LC 5J28A 1USHA 4HD0A 2WDEA 4MP0A 4Q7FA 1HO5A 3H66A 5JPEA 4O43A 4O5GA 4JA7A 3EGHA 5EQVA 4DHLA 5INBA 3QFOA 3H60A 4I5NC 1HPUA 1S3NA 1S95A 5HPEA 1Z2WA 4MOVA 4M0VA 3THNA 2DFJA 2ZOAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AUI A;  1S70 A;  4JA9 A;  2Z06 A;  4NZV A;  3QFM A;  1KBP A;  1U32 A;  2YVT A;  4LAC C;  2XMO A;  4F0Z A;  1XZW A;  2O8A A;  2WDC A;  4UT2 A;  1W24 A;  4KKZ A;  3PSO A;  5DNY A;  3FGA C;  3QG5 C;  1HP1 A;  3DSD A;  3IVD A;  2Z1A A;  3RQZ A;  4FBK A;  3H61 A;  4DSY A;  4H2F A;  2QFP A;  1OIE A;  1QHW A;  2NXF A;  4B2O A;  4ORA A;  2A22 A;  2P6B A;  4ZX2 A;  2IE3 C;  4IYP C;  2NYM C;  3H63 A;  2NYL C;  3H64 A;  2BDX A;  2R17 A;  4LU9 A;  4G9J A;  1TCO A;  2HYP A;  3ICF A;  3IB8 A;  3JYF A;  2CV9 A;  4FCX A;  4TUI A;  4LTY A;  3IVE A;  3T1I A;  4H2G A;  3QFK A;  1II7 A;  1IT6 A;  2O8G A;  4KBP A;  4IL1 A;  1S3L A;  1M63 A;  4MOY A;  2AHD A;  1WAR A;  1UTE A;  3GVE A;  2Q8U A;  3PSN A;  4FBQ A;  4OR9 A;  3V4Y A;  4DT2 A;  4V0V A;  4H1Y P;  3C9F A;  5IOH A;  2JOG A;  1OI8 A;  1V73 A;  3HVQ A;  2IE4 C;  3LL8 A;  4H2B A;  4V0W A;  4ZVZ A;  3TGH A;  4XPN A;  3H67 A;  3DSC A;  3P71 C;  4FBW A;  3K7W C;  2ZBM A;  3KBP A;  4J6O A;  3E7B A;  5B8I A;  4H1S A;  1Z2X A;  3H68 A;  3K7V C;  1S8E A;  3C5W C;  3CK2 A;  5F3W A;  3RL4 A;  3EGG A;  2USH A;  4ORC A;  4YKE A;  4ORB A;  2WDD A;  4UT3 B;  1SU1 A;  2KKN A;  1NNW A;  1S3M A;  1XM7 A;  5JJT A;  1WAO 1;  1G5B A;  2HY1 A;  1FJM A;  1UF3 A;  3AUZ A;  1QFC A;  3H62 B;  3ZU0 A;  4O24 A;  1T71 A;  3RL3 A;  4O4K A;  3H69 A;  5C1V A;  1T70 A;  2QJC A;  1JK7 A;  2BCD A;  4V0X A;  3RL5 A;  1OID A;  2BQ8 X;  3N5U A;  5GTU A;  3ZTV A;  4TUG A;  3E7A A;  4UT3 A;  2NPP C;  3QFN A;  5JPF A;  2GJU A;  2QFR A;  2Z72 A;  3IB7 A;  4H2I A;  3THO B;  3DW8 C;  1MF8 A;  2IAE C;  4UWQ A;  2HYO A;  3AV0 A;  4WWL A;  2WDF A;  4I5L C;  5J28 A;  1USH A;  4HD0 A;  2WDE A;  4MP0 A;  4Q7F A;  1HO5 A;  3H66 A;  5JPE A;  4O43 A;  4O5G A;  4JA7 A;  3EGH A;  5EQV A;  4DHL A;  5INB A;  3QFO A;  3H60 A;  4I5N C;  1HPU A;  1S3N A;  1S95 A;  5HPE A;  1Z2W A;  4MOV A;  4M0V A;  3THN A;  2DFJ A; 
#chains in the Genus database with same CATH topology
 1AUI A;  1S70 A;  4JA9 A;  2Z06 A;  4NZV A;  3QFM A;  1KBP A;  1U32 A;  2YVT A;  4LAC C;  2XMO A;  4F0Z A;  1XZW A;  2O8A A;  2ZO9 B;  2WDC A;  4UT2 A;  1W24 A;  4KKZ A;  3PSO A;  5DNY A;  3FGA C;  3QG5 C;  1HP1 A;  3DSD A;  3IVD A;  2Z1A A;  3RQZ A;  4FBK A;  3H61 A;  4DSY A;  4H2F A;  2QFP A;  1OIE A;  1QHW A;  2NXF A;  4B2O A;  4ORA A;  2A22 A;  2P6B A;  4ZX2 A;  2IE3 C;  4IYP C;  2NYM C;  3H63 A;  2NYL C;  3H64 A;  2BDX A;  2R17 A;  4LU9 A;  4G9J A;  1TCO A;  2HYP A;  3ICF A;  3IB8 A;  3JYF A;  2CV9 A;  4FCX A;  4TUI A;  4LTY A;  3IVE A;  3T1I A;  4H2G A;  3QFK A;  1II7 A;  1IT6 A;  2O8G A;  4KBP A;  4IL1 A;  1S3L A;  1M63 A;  4MOY A;  2AHD A;  1WAR A;  1UTE A;  3GVE A;  2Q8U A;  3PSN A;  4FBQ A;  4OR9 A;  3V4Y A;  4DT2 A;  4V0V A;  4H1Y P;  3C9F A;  5IOH A;  3D03 A;  2JOG A;  1OI8 A;  1V73 A;  3HVQ A;  2IE4 C;  3LL8 A;  4H2B A;  4V0W A;  4ZVZ A;  3TGH A;  4XPN A;  2DXN A;  3H67 A;  3DSC A;  3P71 C;  4FBW A;  3K7W C;  2ZBM A;  3KBP A;  4J6O A;  3E7B A;  5B8I A;  4H1S A;  1Z2X A;  3H68 A;  3K7V C;  1S8E A;  3C5W C;  3CK2 A;  5F3W A;  3RL4 A;  3EGG A;  2USH A;  4ORC A;  4YKE A;  4ORB A;  2DXL A;  2WDD A;  3E0J A;  4UT3 B;  1SU1 A;  2YEQ A;  2KKN A;  1NNW A;  1S3M A;  1XM7 A;  5JJT A;  1WAO 1;  1G5B A;  2HY1 A;  1FJM A;  1UF3 A;  3AUZ A;  1QFC A;  3H62 B;  3FLO A;  3ZU0 A;  4O24 A;  1T71 A;  3RL3 A;  4O4K A;  3H69 A;  5C1V A;  1T70 A;  2QJC A;  1JK7 A;  2BCD A;  4V0X A;  3RL5 A;  1OID A;  2BQ8 X;  3N5U A;  5GTU A;  3ZTV A;  4TUG A;  3E7A A;  4UT3 A;  2NPP C;  3QFN A;  5JPF A;  2GJU A;  2QFR A;  2Z72 A;  3IB7 A;  4H2I A;  3THO B;  3DW8 C;  1MF8 A;  2IAE C;  4UWQ A;  2HYO A;  3AV0 A;  4WWL A;  2WDF A;  4I5L C;  5J28 A;  1USH A;  4HD0 A;  2WDE A;  4MP0 A;  4Q7F A;  1HO5 A;  3H66 A;  5JPE A;  4O43 A;  4O5G A;  4JA7 A;  3EGH A;  5EQV A;  4DHL A;  5INB A;  3QFO A;  3H60 A;  4I5N C;  1HPU A;  1S3N A;  1S95 A;  5HPE A;  1Z2W A;  4MOV A;  4M0V A;  3THN A;  2DFJ A;  2ZOA A; 
#chains in the Genus database with same CATH homology
 1AUI A;  1S70 A;  4JA9 A;  2Z06 A;  4NZV A;  3QFM A;  1KBP A;  1U32 A;  2YVT A;  4LAC C;  2XMO A;  4F0Z A;  1XZW A;  2O8A A;  2ZO9 B;  2WDC A;  4UT2 A;  1W24 A;  4KKZ A;  3PSO A;  5DNY A;  3FGA C;  3QG5 C;  1HP1 A;  3DSD A;  3IVD A;  2Z1A A;  3RQZ A;  4FBK A;  3H61 A;  4DSY A;  4H2F A;  2QFP A;  1OIE A;  1QHW A;  2NXF A;  4B2O A;  4ORA A;  2A22 A;  2P6B A;  4ZX2 A;  2IE3 C;  4IYP C;  2NYM C;  3H63 A;  2NYL C;  3H64 A;  2BDX A;  2R17 A;  4LU9 A;  4G9J A;  1TCO A;  2HYP A;  3ICF A;  3IB8 A;  3JYF A;  2CV9 A;  4FCX A;  4TUI A;  4LTY A;  3IVE A;  3T1I A;  4H2G A;  3QFK A;  1II7 A;  1IT6 A;  2O8G A;  4KBP A;  4IL1 A;  1S3L A;  1M63 A;  4MOY A;  2AHD A;  1WAR A;  1UTE A;  3GVE A;  2Q8U A;  3PSN A;  4FBQ A;  4OR9 A;  3V4Y A;  4DT2 A;  4V0V A;  4H1Y P;  3C9F A;  5IOH A;  3D03 A;  2JOG A;  1OI8 A;  1V73 A;  3HVQ A;  2IE4 C;  3LL8 A;  4H2B A;  4V0W A;  4ZVZ A;  3TGH A;  4XPN A;  2DXN A;  3H67 A;  3DSC A;  3P71 C;  4FBW A;  3K7W C;  2ZBM A;  3KBP A;  4J6O A;  3E7B A;  5B8I A;  4H1S A;  1Z2X A;  3H68 A;  3K7V C;  1S8E A;  3C5W C;  3CK2 A;  5F3W A;  3RL4 A;  3EGG A;  2USH A;  4ORC A;  4YKE A;  4ORB A;  2DXL A;  2WDD A;  3E0J A;  4UT3 B;  1SU1 A;  2YEQ A;  2KKN A;  1NNW A;  1S3M A;  1XM7 A;  5JJT A;  1WAO 1;  1G5B A;  2HY1 A;  1FJM A;  1UF3 A;  3AUZ A;  1QFC A;  3H62 B;  3FLO A;  3ZU0 A;  4O24 A;  1T71 A;  3RL3 A;  4O4K A;  3H69 A;  5C1V A;  1T70 A;  2QJC A;  1JK7 A;  2BCD A;  4V0X A;  3RL5 A;  1OID A;  2BQ8 X;  3N5U A;  5GTU A;  3ZTV A;  4TUG A;  3E7A A;  4UT3 A;  2NPP C;  3QFN A;  5JPF A;  2GJU A;  2QFR A;  2Z72 A;  3IB7 A;  4H2I A;  3THO B;  3DW8 C;  1MF8 A;  2IAE C;  4UWQ A;  2HYO A;  3AV0 A;  4WWL A;  2WDF A;  4I5L C;  5J28 A;  1USH A;  4HD0 A;  2WDE A;  4MP0 A;  4Q7F A;  1HO5 A;  3H66 A;  5JPE A;  4O43 A;  4O5G A;  4JA7 A;  3EGH A;  5EQV A;  4DHL A;  5INB A;  3QFO A;  3H60 A;  4I5N C;  1HPU A;  1S3N A;  1S95 A;  5HPE A;  1Z2W A;  4MOV A;  4M0V A;  3THN A;  2DFJ A;  2ZOA A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...