5IOHA

Repoman-pp1a (protein phosphatase 1, alpha isoform) holoenzyme complex
Total Genus 104
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
104
sequence length
293
structure length
293
Chain Sequence
LNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism.
pubmed doi rcsb
molecule tags Hydrolase/protein binding
source organism Homo sapiens
molecule keywords Serine/threonine-protein phosphatase PP1-alpha catalytic sub
total genus 104
structure length 293
sequence length 293
chains with identical sequence C
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2016-03-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF16891 STPPase_N Serine-threonine protein phosphatase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 5iohA00
1S70A 3AV0A 3EGHA 3IB8A 4FBQA 4H1YP 2NYMC 3H67A 4M0VA 1KBPA 1FJMA 2O8AA 4V0WA 2KKNA 1T71A 4FBKA 1T70A 4O24A 3K7VC 4DT2A 2WDCA 1S3MA 2USHA 2Q8UA 2A22A 4LTYA 3RQZA 3H62B 3H68A 3TGHA 1S3LA 2WDDA 2Z06A 4H2IA 4MOYA 3IVDA 3ZU0A 2GJUA 4UT3A 1Z2WA 3C5WC 3RL3A 1IT6A 1U32A 2O8GA 3H66A 3DSDA 2IE4C 1MF8A 3IB7A 5DNYA 2NPPC 2P6BA 1HPUA 3RL5A 3P71C 4TUGA 3QFMA 4H2FA 4IYPC 5C1VA 3K7WC 4ZX2A 4O43A 2Z72A 4TUIA 1W24A 5JPFA 3E7AA 4HD0A 4XPNA 4UT2A 3HVQA 3QG5C 1II7A 2IAEC 3H64A 3AUZA 1XM7A 2NXFA 3DW8C 4JA7A 2DFJA 3C9FA 1XZWA 4FBWA 4ORCA 1HO5A 3THNA 5INBA 4J6OA 1S3NA 4NZVA 5JJTA 1M63A 3QFNA 3EGGA 4DSYA 2WDEA 3IVEA 4H2BA 2Z1AA 3THOB 4LACC 3LL8A 1WAO1 3DSCA 2HYPA 1S95A 1AUIA 3H60A 3KBPA 2QFRA 1NNWA 3T1IA 3ZTVA 3H61A 1UTEA 4IL1A 2CV9A 4I5LC 4V0VA 4MP0A 2HY1A 2JOGA 4KBPA 3RL4A 1OIDA 5J28A 2QJCA 4UWQA 2ZBMA 2BCDA 4B2OA 3ICFA 2YVTA 1UF3A 4O5GA 4YKEA 4LU9A 1JK7A 3FGAC 3PSOA 2XMOA 4I5NC 4V0XA 1QFCA 1G5BA 4KKZA 1OIEA 1Z2XA 3N5UA 2BQ8X 2R17A 1TCOA 5JPEA 3V4YA 1V73A 4ORAA 1SU1A 2QFPA 4F0ZA 3QFKA 2BDXA 3H69A 4DHLA 2WDFA 1WARA 4FCXA 4O4KA 4ORBA 3QFOA 5EQVA 5GTUA 2AHDA 4MOVA 5B8IA 1S8EA 4Q7FA 5F3WA 4OR9A 1QHWA 5HPEA 3H63A 3GVEA 1HP1A 2HYOA 3CK2A 1USHA 4ZVZA 3PSNA 4G9JA 5IOHA 4H2GA 4JA9A 1OI8A 2IE3C 2NYLC 4H1SA 3JYFA 3E7BA 4WWLA 4UT3B
chains in the Genus database with same CATH superfamily
1S70A 3AV0A 3EGHA 3IB8A 4FBQA 4H1YP 2NYMC 3H67A 4M0VA 1KBPA 1FJMA 2O8AA 4V0WA 2KKNA 1T71A 4FBKA 3FLOA 1T70A 4O24A 3K7VC 4DT2A 2WDCA 1S3MA 2USHA 2Q8UA 2A22A 4LTYA 3RQZA 3H62B 3H68A 3TGHA 1S3LA 2WDDA 2Z06A 4H2IA 4MOYA 3IVDA 3ZU0A 2GJUA 4UT3A 1Z2WA 3C5WC 3RL3A 1IT6A 1U32A 2O8GA 3H66A 3DSDA 2IE4C 1MF8A 3IB7A 5DNYA 2NPPC 2P6BA 1HPUA 3RL5A 3P71C 4TUGA 3QFMA 4H2FA 4IYPC 5C1VA 3K7WC 4ZX2A 4O43A 2Z72A 4TUIA 2DXNA 1W24A 5JPFA 3E7AA 4HD0A 4XPNA 4UT2A 3HVQA 3QG5C 1II7A 2IAEC 3H64A 3AUZA 1XM7A 3D03A 2NXFA 3DW8C 4JA7A 2DFJA 3C9FA 1XZWA 4FBWA 4ORCA 1HO5A 3THNA 3E0JA 5INBA 4J6OA 1S3NA 4NZVA 5JJTA 1M63A 3QFNA 2ZOAA 3EGGA 4DSYA 2WDEA 3IVEA 4H2BA 2Z1AA 3THOB 4LACC 3LL8A 1WAO1 3DSCA 2HYPA 1S95A 1AUIA 3E7BA 3H60A 3KBPA 2QFRA 1NNWA 3T1IA 3ZTVA 3H61A 1UTEA 4IL1A 2CV9A 4I5LC 4V0VA 4MP0A 2HY1A 2JOGA 4KBPA 3RL4A 1OIDA 5J28A 2QJCA 4UWQA 2ZBMA 2BCDA 4B2OA 3ICFA 2YVTA 1UF3A 4O5GA 4YKEA 4LU9A 1JK7A 2DXLA 3FGAC 2XMOA 3PSOA 4I5NC 1QFCA 1G5BA 4V0XA 4KKZA 1OIEA 1Z2XA 2ZO9B 3N5UA 2BQ8X 2R17A 1TCOA 5JPEA 3V4YA 1V73A 4ORAA 1SU1A 2QFPA 4F0ZA 3QFKA 2BDXA 3H69A 4DHLA 2WDFA 1WARA 4FCXA 4O4KA 4ORBA 3QFOA 5EQVA 5GTUA 2AHDA 4MOVA 5B8IA 1S8EA 4Q7FA 5F3WA 4OR9A 1QHWA 5HPEA 3H63A 3GVEA 1HP1A 2HYOA 3CK2A 1USHA 4ZVZA 3PSNA 4G9JA 5IOHA 4H2GA 4JA9A 1OI8A 2IE3C 2NYLC 4H1SA 3JYFA 2YEQA 4WWLA 4UT3B
chains in the Genus database with same CATH topology
1S70A 3AV0A 3EGHA 3IB8A 4FBQA 4H1YP 2NYMC 3H67A 4M0VA 1KBPA 1FJMA 2O8AA 4V0WA 2KKNA 1T71A 4FBKA 3FLOA 1T70A 4O24A 3K7VC 4DT2A 2WDCA 1S3MA 2USHA 2Q8UA 2A22A 4LTYA 3RQZA 3H62B 3H68A 3TGHA 1S3LA 2WDDA 2Z06A 4H2IA 4MOYA 3IVDA 3ZU0A 2GJUA 4UT3A 1Z2WA 3C5WC 3RL3A 1IT6A 1U32A 2O8GA 3H66A 3DSDA 2IE4C 1MF8A 3IB7A 5DNYA 2NPPC 2P6BA 1HPUA 3RL5A 3P71C 4TUGA 3QFMA 4H2FA 4IYPC 5C1VA 3K7WC 4ZX2A 4O43A 2Z72A 4TUIA 2DXNA 1W24A 5JPFA 3E7AA 4HD0A 4XPNA 4UT2A 3HVQA 3QG5C 1II7A 2IAEC 3H64A 3AUZA 1XM7A 3D03A 2NXFA 3DW8C 4JA7A 2DFJA 3C9FA 1XZWA 4FBWA 4ORCA 1HO5A 3THNA 3E0JA 5INBA 4J6OA 1S3NA 4NZVA 5JJTA 1M63A 3QFNA 2ZOAA 3EGGA 4DSYA 2WDEA 3IVEA 4H2BA 2Z1AA 3THOB 4LACC 3LL8A 1WAO1 3DSCA 2HYPA 1S95A 1AUIA 3E7BA 3H60A 3KBPA 2QFRA 1NNWA 3T1IA 3ZTVA 3H61A 1UTEA 4IL1A 2CV9A 4I5LC 4V0VA 4MP0A 2HY1A 2JOGA 4KBPA 3RL4A 1OIDA 5J28A 2QJCA 4UWQA 2ZBMA 2BCDA 4B2OA 3ICFA 2YVTA 1UF3A 4O5GA 4YKEA 4LU9A 1JK7A 2DXLA 3FGAC 2XMOA 3PSOA 4I5NC 1QFCA 1G5BA 4V0XA 4KKZA 1OIEA 1Z2XA 2ZO9B 3N5UA 2BQ8X 2R17A 1TCOA 5JPEA 3V4YA 1V73A 4ORAA 1SU1A 2QFPA 4F0ZA 3QFKA 2BDXA 3H69A 4DHLA 2WDFA 1WARA 4FCXA 4O4KA 4ORBA 3QFOA 5EQVA 5GTUA 2AHDA 4MOVA 5B8IA 1S8EA 4Q7FA 5F3WA 4OR9A 1QHWA 5HPEA 3H63A 3GVEA 1HP1A 2HYOA 3CK2A 1USHA 4ZVZA 3PSNA 4G9JA 5IOHA 4H2GA 4JA9A 1OI8A 2IE3C 2NYLC 4H1SA 3JYFA 2YEQA 4WWLA 4UT3B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1S70 A;  3AV0 A;  3EGH A;  3IB8 A;  4FBQ A;  4H1Y P;  2NYM C;  3H67 A;  4M0V A;  1KBP A;  1FJM A;  2O8A A;  4V0W A;  2KKN A;  1T71 A;  4FBK A;  1T70 A;  4O24 A;  3K7V C;  4DT2 A;  2WDC A;  1S3M A;  2USH A;  2Q8U A;  2A22 A;  4LTY A;  3RQZ A;  3H62 B;  3H68 A;  3TGH A;  1S3L A;  2WDD A;  2Z06 A;  4H2I A;  4MOY A;  3IVD A;  3ZU0 A;  2GJU A;  4UT3 A;  1Z2W A;  3C5W C;  3RL3 A;  1IT6 A;  1U32 A;  2O8G A;  3H66 A;  3DSD A;  2IE4 C;  1MF8 A;  3IB7 A;  5DNY A;  2NPP C;  2P6B A;  1HPU A;  3RL5 A;  3P71 C;  4TUG A;  3QFM A;  4H2F A;  4IYP C;  5C1V A;  3K7W C;  4ZX2 A;  4O43 A;  2Z72 A;  4TUI A;  1W24 A;  5JPF A;  3E7A A;  4HD0 A;  4XPN A;  4UT2 A;  3HVQ A;  3QG5 C;  1II7 A;  2IAE C;  3H64 A;  3AUZ A;  1XM7 A;  2NXF A;  3DW8 C;  4JA7 A;  2DFJ A;  3C9F A;  1XZW A;  4FBW A;  4ORC A;  1HO5 A;  3THN A;  5INB A;  4J6O A;  1S3N A;  4NZV A;  5JJT A;  1M63 A;  3QFN A;  3EGG A;  4DSY A;  2WDE A;  3IVE A;  4H2B A;  2Z1A A;  3THO B;  4LAC C;  3LL8 A;  1WAO 1;  3DSC A;  2HYP A;  1S95 A;  1AUI A;  3H60 A;  3KBP A;  2QFR A;  1NNW A;  3T1I A;  3ZTV A;  3H61 A;  1UTE A;  4IL1 A;  2CV9 A;  4I5L C;  4V0V A;  4MP0 A;  2HY1 A;  2JOG A;  4KBP A;  3RL4 A;  1OID A;  5J28 A;  2QJC A;  4UWQ A;  2ZBM A;  2BCD A;  4B2O A;  3ICF A;  2YVT A;  1UF3 A;  4O5G A;  4YKE A;  4LU9 A;  1JK7 A;  3FGA C;  3PSO A;  2XMO A;  4I5N C;  4V0X A;  1QFC A;  1G5B A;  4KKZ A;  1OIE A;  1Z2X A;  3N5U A;  2BQ8 X;  2R17 A;  1TCO A;  5JPE A;  3V4Y A;  1V73 A;  4ORA A;  1SU1 A;  2QFP A;  4F0Z A;  3QFK A;  2BDX A;  3H69 A;  4DHL A;  2WDF A;  1WAR A;  4FCX A;  4O4K A;  4ORB A;  3QFO A;  5EQV A;  5GTU A;  2AHD A;  4MOV A;  5B8I A;  1S8E A;  4Q7F A;  5F3W A;  4OR9 A;  1QHW A;  5HPE A;  3H63 A;  3GVE A;  1HP1 A;  2HYO A;  3CK2 A;  1USH A;  4ZVZ A;  3PSN A;  4G9J A;  5IOH A;  4H2G A;  4JA9 A;  1OI8 A;  2IE3 C;  2NYL C;  4H1S A;  3JYF A;  3E7B A;  4WWL A;  4UT3 B; 
#chains in the Genus database with same CATH topology
 1S70 A;  3AV0 A;  3EGH A;  3IB8 A;  4FBQ A;  4H1Y P;  2NYM C;  3H67 A;  4M0V A;  1KBP A;  1FJM A;  2O8A A;  4V0W A;  2KKN A;  1T71 A;  4FBK A;  3FLO A;  1T70 A;  4O24 A;  3K7V C;  4DT2 A;  2WDC A;  1S3M A;  2USH A;  2Q8U A;  2A22 A;  4LTY A;  3RQZ A;  3H62 B;  3H68 A;  3TGH A;  1S3L A;  2WDD A;  2Z06 A;  4H2I A;  4MOY A;  3IVD A;  3ZU0 A;  2GJU A;  4UT3 A;  1Z2W A;  3C5W C;  3RL3 A;  1IT6 A;  1U32 A;  2O8G A;  3H66 A;  3DSD A;  2IE4 C;  1MF8 A;  3IB7 A;  5DNY A;  2NPP C;  2P6B A;  1HPU A;  3RL5 A;  3P71 C;  4TUG A;  3QFM A;  4H2F A;  4IYP C;  5C1V A;  3K7W C;  4ZX2 A;  4O43 A;  2Z72 A;  4TUI A;  2DXN A;  1W24 A;  5JPF A;  3E7A A;  4HD0 A;  4XPN A;  4UT2 A;  3HVQ A;  3QG5 C;  1II7 A;  2IAE C;  3H64 A;  3AUZ A;  1XM7 A;  3D03 A;  2NXF A;  3DW8 C;  4JA7 A;  2DFJ A;  3C9F A;  1XZW A;  4FBW A;  4ORC A;  1HO5 A;  3THN A;  3E0J A;  5INB A;  4J6O A;  1S3N A;  4NZV A;  5JJT A;  1M63 A;  3QFN A;  2ZOA A;  3EGG A;  4DSY A;  2WDE A;  3IVE A;  4H2B A;  2Z1A A;  3THO B;  4LAC C;  3LL8 A;  1WAO 1;  3DSC A;  2HYP A;  1S95 A;  1AUI A;  3E7B A;  3H60 A;  3KBP A;  2QFR A;  1NNW A;  3T1I A;  3ZTV A;  3H61 A;  1UTE A;  4IL1 A;  2CV9 A;  4I5L C;  4V0V A;  4MP0 A;  2HY1 A;  2JOG A;  4KBP A;  3RL4 A;  1OID A;  5J28 A;  2QJC A;  4UWQ A;  2ZBM A;  2BCD A;  4B2O A;  3ICF A;  2YVT A;  1UF3 A;  4O5G A;  4YKE A;  4LU9 A;  1JK7 A;  2DXL A;  3FGA C;  2XMO A;  3PSO A;  4I5N C;  1QFC A;  1G5B A;  4V0X A;  4KKZ A;  1OIE A;  1Z2X A;  2ZO9 B;  3N5U A;  2BQ8 X;  2R17 A;  1TCO A;  5JPE A;  3V4Y A;  1V73 A;  4ORA A;  1SU1 A;  2QFP A;  4F0Z A;  3QFK A;  2BDX A;  3H69 A;  4DHL A;  2WDF A;  1WAR A;  4FCX A;  4O4K A;  4ORB A;  3QFO A;  5EQV A;  5GTU A;  2AHD A;  4MOV A;  5B8I A;  1S8E A;  4Q7F A;  5F3W A;  4OR9 A;  1QHW A;  5HPE A;  3H63 A;  3GVE A;  1HP1 A;  2HYO A;  3CK2 A;  1USH A;  4ZVZ A;  3PSN A;  4G9J A;  5IOH A;  4H2G A;  4JA9 A;  1OI8 A;  2IE3 C;  2NYL C;  4H1S A;  3JYF A;  2YEQ A;  4WWL A;  4UT3 B; 
#chains in the Genus database with same CATH homology
 1S70 A;  3AV0 A;  3EGH A;  3IB8 A;  4FBQ A;  4H1Y P;  2NYM C;  3H67 A;  4M0V A;  1KBP A;  1FJM A;  2O8A A;  4V0W A;  2KKN A;  1T71 A;  4FBK A;  3FLO A;  1T70 A;  4O24 A;  3K7V C;  4DT2 A;  2WDC A;  1S3M A;  2USH A;  2Q8U A;  2A22 A;  4LTY A;  3RQZ A;  3H62 B;  3H68 A;  3TGH A;  1S3L A;  2WDD A;  2Z06 A;  4H2I A;  4MOY A;  3IVD A;  3ZU0 A;  2GJU A;  4UT3 A;  1Z2W A;  3C5W C;  3RL3 A;  1IT6 A;  1U32 A;  2O8G A;  3H66 A;  3DSD A;  2IE4 C;  1MF8 A;  3IB7 A;  5DNY A;  2NPP C;  2P6B A;  1HPU A;  3RL5 A;  3P71 C;  4TUG A;  3QFM A;  4H2F A;  4IYP C;  5C1V A;  3K7W C;  4ZX2 A;  4O43 A;  2Z72 A;  4TUI A;  2DXN A;  1W24 A;  5JPF A;  3E7A A;  4HD0 A;  4XPN A;  4UT2 A;  3HVQ A;  3QG5 C;  1II7 A;  2IAE C;  3H64 A;  3AUZ A;  1XM7 A;  3D03 A;  2NXF A;  3DW8 C;  4JA7 A;  2DFJ A;  3C9F A;  1XZW A;  4FBW A;  4ORC A;  1HO5 A;  3THN A;  3E0J A;  5INB A;  4J6O A;  1S3N A;  4NZV A;  5JJT A;  1M63 A;  3QFN A;  2ZOA A;  3EGG A;  4DSY A;  2WDE A;  3IVE A;  4H2B A;  2Z1A A;  3THO B;  4LAC C;  3LL8 A;  1WAO 1;  3DSC A;  2HYP A;  1S95 A;  1AUI A;  3E7B A;  3H60 A;  3KBP A;  2QFR A;  1NNW A;  3T1I A;  3ZTV A;  3H61 A;  1UTE A;  4IL1 A;  2CV9 A;  4I5L C;  4V0V A;  4MP0 A;  2HY1 A;  2JOG A;  4KBP A;  3RL4 A;  1OID A;  5J28 A;  2QJC A;  4UWQ A;  2ZBM A;  2BCD A;  4B2O A;  3ICF A;  2YVT A;  1UF3 A;  4O5G A;  4YKE A;  4LU9 A;  1JK7 A;  2DXL A;  3FGA C;  2XMO A;  3PSO A;  4I5N C;  1QFC A;  1G5B A;  4V0X A;  4KKZ A;  1OIE A;  1Z2X A;  2ZO9 B;  3N5U A;  2BQ8 X;  2R17 A;  1TCO A;  5JPE A;  3V4Y A;  1V73 A;  4ORA A;  1SU1 A;  2QFP A;  4F0Z A;  3QFK A;  2BDX A;  3H69 A;  4DHL A;  2WDF A;  1WAR A;  4FCX A;  4O4K A;  4ORB A;  3QFO A;  5EQV A;  5GTU A;  2AHD A;  4MOV A;  5B8I A;  1S8E A;  4Q7F A;  5F3W A;  4OR9 A;  1QHW A;  5HPE A;  3H63 A;  3GVE A;  1HP1 A;  2HYO A;  3CK2 A;  1USH A;  4ZVZ A;  3PSN A;  4G9J A;  5IOH A;  4H2G A;  4JA9 A;  1OI8 A;  2IE3 C;  2NYL C;  4H1S A;  3JYF A;  2YEQ A;  4WWL A;  4UT3 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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