4H2FA

Human ecto-5'-nucleotidase (cd73): crystal form i (open) in complex with adenosine
Total Genus 174
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
174
sequence length
524
structure length
524
Chain Sequence
PWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHADEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTACAVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords 5'-nucleotidase
total genus 174
structure length 524
sequence length 524
ec nomenclature ec 3.1.3.5: 5'-nucleotidase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF02872 5_nucleotid_C 5'-nucleotidase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4h2fA01
3.90.780.10 Alpha Beta Alpha-Beta Complex 5'-nucleotidase; domain 2 5'-Nucleotidase, C-terminal domain 4h2fA02
4ORAA 4IYPC 3P71C 3QFKA 3DW8C 4ORCA 4LTYA 1UTEA 1G5BA 4WWLA 1AUIA 4MP0A 1IT6A 3JYFA 3EGGA 2BQ8X 2WDFA 3H66A 1XM7A 1QFCA 2QFRA 1WARA 4IL1A 3PSOA 5B8IA 2WDDA 4XPNA 1II7A 3C9FA 2A22A 2BDXA 3CK2A 5HPEA 1Z2WA 3H68A 4V0VA 3THNA 2CV9A 5JJTA 4OR9A 3QFOA 1S8EA 4H2IA 3THOB 3QG5C 3IB8A 4KBPA 4Q7FA 1XZWA 2IAEC 2NXFA 3ICFA 2XMOA 1NNWA 2NYLC 4FBQA 4UWQA 1OIDA 2IE4C 1S70A 2JOGA 1S95A 4DSYA 2QFPA 3IVEA 1OIEA 1Z2XA 4ZVZA 2HY1A 3RL5A 3RQZA 4TUGA 3QFNA 2Z06A 2WDEA 2WDCA 5EQVA 5DNYA 2O8AA 1KBPA 2O8GA 4M0VA 4O24A 3HVQA 4H2GA 5INBA 4V0XA 2NPPC 1U32A 3H62B 4MOYA 4UT3B 5IOHA 3H69A 3IVDA 4JA7A 3IB7A 3RL4A 4DHLA 2ZBMA 5J28A 4UT2A 2AHDA 5GTUA 2NYMC 2Z1AA 4LU9A 1SU1A 2DFJA 3AV0A 5JPFA 1S3MA 4I5LC 4G9JA 3ZTVA 1JK7A 1FJMA 3FGAC 3ZU0A 2KKNA 5C1VA 1MF8A 4O43A 3H60A 3T1IA 4F0ZA 3C5WC 3GVEA 4LACC 3E7AA 4FCXA 2QJCA 1T71A 4HD0A 4H2FA 4O4KA 1V73A 5F3WA 4H1YP 4MOVA 1WAO1 3AUZA 3DSCA 4H1SA 3TGHA 3K7WC 4ZX2A 4V0WA 4I5NC 2YVTA 1HO5A 2Z72A 4J6OA 3RL3A 3PSNA 1W24A 3DSDA 3QFMA 3EGHA 3V4YA 1S3NA 1S3LA 1T70A 1HP1A 1USHA 2GJUA 3H63A 5JPEA 4TUIA 1HPUA 3K7VC 2BCDA 2IE3C 4NZVA 2P6BA 4YKEA 3H67A 3N5UA 4ORBA 4DT2A 3H64A 1UF3A 2R17A 4FBKA 1M63A 4B2OA 4UT3A 4O5GA 4JA9A 3E7BA 2HYOA 2HYPA 1TCOA 3KBPA 4KKZA 2Q8UA 1OI8A 2USHA 3H61A 1QHWA 4H2BA 3LL8A 4FBWA
chains in the Genus database with same CATH superfamily
4ORAA 4IYPC 3P71C 3QFKA 3DW8C 4ORCA 4LTYA 1UTEA 1G5BA 4WWLA 1AUIA 4MP0A 1IT6A 3JYFA 3EGGA 2BQ8X 2WDFA 3H66A 1XM7A 1QFCA 2QFRA 1WARA 4IL1A 3PSOA 5B8IA 2WDDA 4XPNA 1II7A 3C9FA 2A22A 2BDXA 3CK2A 5HPEA 1Z2WA 3D03A 3H68A 4V0VA 3THNA 2CV9A 5JJTA 4OR9A 3QFOA 1S8EA 4H2IA 3THOB 3QG5C 3IB8A 4KBPA 4Q7FA 1XZWA 2IAEC 2NXFA 3ICFA 2XMOA 1NNWA 2NYLC 4FBQA 4UWQA 1OIDA 2IE4C 1S70A 2JOGA 1S95A 4DSYA 2QFPA 3IVEA 1OIEA 2ZO9B 1Z2XA 4ZVZA 2HY1A 3RL5A 3RQZA 4TUGA 3QFNA 2Z06A 2WDEA 2ZOAA 2WDCA 5EQVA 5DNYA 2O8AA 1KBPA 2O8GA 4M0VA 4O24A 3HVQA 4H2GA 5INBA 2DXLA 4V0XA 2NPPC 1U32A 3H62B 4MOYA 4UT3B 5IOHA 3H69A 2DXNA 3IVDA 4JA7A 3IB7A 3RL4A 3E0JA 4DHLA 2ZBMA 5J28A 4UT2A 2AHDA 5GTUA 2NYMC 2Z1AA 4LU9A 3FLOA 1SU1A 2DFJA 3AV0A 5JPFA 1S3MA 4I5LC 4G9JA 3ZTVA 1JK7A 1FJMA 3FGAC 3ZU0A 2KKNA 5C1VA 1MF8A 4O43A 3H60A 3T1IA 4F0ZA 3C5WC 3GVEA 4LACC 3E7AA 4FCXA 2QJCA 1T71A 4HD0A 4H2FA 4O4KA 1V73A 5F3WA 4H1YP 4MOVA 1WAO1 3AUZA 3DSCA 4H1SA 3TGHA 3K7WC 4ZX2A 4V0WA 4I5NC 2YVTA 1HO5A 2Z72A 4J6OA 3RL3A 3PSNA 1W24A 3DSDA 3QFMA 3EGHA 3V4YA 1S3NA 1S3LA 1T70A 1HP1A 1USHA 2GJUA 2YEQA 3H63A 5JPEA 1HPUA 3K7VC 4TUIA 2BCDA 2IE3C 4NZVA 2P6BA 4YKEA 3H67A 3N5UA 4ORBA 4DT2A 3H64A 1UF3A 2R17A 4FBKA 1M63A 4B2OA 4UT3A 4O5GA 4JA9A 3E7BA 2HYOA 2HYPA 1TCOA 3KBPA 4KKZA 2Q8UA 1OI8A 2USHA 3H61A 1QHWA 4H2BA 3LL8A 4FBWA
chains in the Genus database with same CATH topology
4ORAA 4IYPC 3P71C 3QFKA 3DW8C 4ORCA 4LTYA 1UTEA 1G5BA 4WWLA 1AUIA 4MP0A 1IT6A 3JYFA 3EGGA 2BQ8X 2WDFA 3H66A 1XM7A 1QFCA 2QFRA 1WARA 4IL1A 3PSOA 5B8IA 2WDDA 4XPNA 1II7A 3C9FA 2A22A 2BDXA 3CK2A 5HPEA 1Z2WA 3D03A 3H68A 4V0VA 3THNA 2CV9A 5JJTA 4OR9A 3QFOA 1S8EA 4H2IA 3THOB 3QG5C 3IB8A 4KBPA 4Q7FA 1XZWA 2IAEC 2NXFA 3ICFA 2XMOA 1NNWA 2NYLC 4FBQA 4UWQA 1OIDA 2IE4C 1S70A 2JOGA 1S95A 4DSYA 2QFPA 3IVEA 1OIEA 2ZO9B 1Z2XA 4ZVZA 2HY1A 3RL5A 3RQZA 4TUGA 3QFNA 2Z06A 2WDEA 2ZOAA 2WDCA 5EQVA 5DNYA 2O8AA 1KBPA 2O8GA 4M0VA 4O24A 3HVQA 4H2GA 5INBA 2DXLA 4V0XA 2NPPC 1U32A 3H62B 4MOYA 4UT3B 5IOHA 3H69A 2DXNA 3IVDA 4JA7A 3IB7A 3RL4A 3E0JA 4DHLA 2ZBMA 5J28A 4UT2A 2AHDA 5GTUA 2NYMC 2Z1AA 4LU9A 3FLOA 1SU1A 2DFJA 3AV0A 5JPFA 1S3MA 4I5LC 4G9JA 3ZTVA 1JK7A 1FJMA 3FGAC 3ZU0A 2KKNA 5C1VA 1MF8A 4O43A 3H60A 3T1IA 4F0ZA 3C5WC 3GVEA 4LACC 3E7AA 4FCXA 2QJCA 1T71A 4HD0A 4H2FA 4O4KA 1V73A 5F3WA 4H1YP 4MOVA 1WAO1 3AUZA 3DSCA 4H1SA 3TGHA 3K7WC 4ZX2A 4V0WA 4I5NC 2YVTA 1HO5A 2Z72A 4J6OA 3RL3A 3PSNA 1W24A 3DSDA 3QFMA 3EGHA 3V4YA 1S3NA 1S3LA 1T70A 1HP1A 1USHA 2GJUA 2YEQA 3H63A 5JPEA 1HPUA 3K7VC 4TUIA 2BCDA 2IE3C 4NZVA 2P6BA 4YKEA 3H67A 3N5UA 4ORBA 4DT2A 3H64A 1UF3A 2R17A 4FBKA 1M63A 4B2OA 4UT3A 4O5GA 4JA9A 3E7BA 2HYOA 2HYPA 1TCOA 3KBPA 4KKZA 2Q8UA 1OI8A 2USHA 3H61A 1QHWA 4H2BA 3LL8A 4FBWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ORA A;  4IYP C;  3P71 C;  3QFK A;  3DW8 C;  4ORC A;  4LTY A;  1UTE A;  1G5B A;  4WWL A;  1AUI A;  4MP0 A;  1IT6 A;  3JYF A;  3EGG A;  2BQ8 X;  2WDF A;  3H66 A;  1XM7 A;  1QFC A;  2QFR A;  1WAR A;  4IL1 A;  3PSO A;  5B8I A;  2WDD A;  4XPN A;  1II7 A;  3C9F A;  2A22 A;  2BDX A;  3CK2 A;  5HPE A;  1Z2W A;  3H68 A;  4V0V A;  3THN A;  2CV9 A;  5JJT A;  4OR9 A;  3QFO A;  1S8E A;  4H2I A;  3THO B;  3QG5 C;  3IB8 A;  4KBP A;  4Q7F A;  1XZW A;  2IAE C;  2NXF A;  3ICF A;  2XMO A;  1NNW A;  2NYL C;  4FBQ A;  4UWQ A;  1OID A;  2IE4 C;  1S70 A;  2JOG A;  1S95 A;  4DSY A;  2QFP A;  3IVE A;  1OIE A;  1Z2X A;  4ZVZ A;  2HY1 A;  3RL5 A;  3RQZ A;  4TUG A;  3QFN A;  2Z06 A;  2WDE A;  2WDC A;  5EQV A;  5DNY A;  2O8A A;  1KBP A;  2O8G A;  4M0V A;  4O24 A;  3HVQ A;  4H2G A;  5INB A;  4V0X A;  2NPP C;  1U32 A;  3H62 B;  4MOY A;  4UT3 B;  5IOH A;  3H69 A;  3IVD A;  4JA7 A;  3IB7 A;  3RL4 A;  4DHL A;  2ZBM A;  5J28 A;  4UT2 A;  2AHD A;  5GTU A;  2NYM C;  2Z1A A;  4LU9 A;  1SU1 A;  2DFJ A;  3AV0 A;  5JPF A;  1S3M A;  4I5L C;  4G9J A;  3ZTV A;  1JK7 A;  1FJM A;  3FGA C;  3ZU0 A;  2KKN A;  5C1V A;  1MF8 A;  4O43 A;  3H60 A;  3T1I A;  4F0Z A;  3C5W C;  3GVE A;  4LAC C;  3E7A A;  4FCX A;  2QJC A;  1T71 A;  4HD0 A;  4H2F A;  4O4K A;  1V73 A;  5F3W A;  4H1Y P;  4MOV A;  1WAO 1;  3AUZ A;  3DSC A;  4H1S A;  3TGH A;  3K7W C;  4ZX2 A;  4V0W A;  4I5N C;  2YVT A;  1HO5 A;  2Z72 A;  4J6O A;  3RL3 A;  3PSN A;  1W24 A;  3DSD A;  3QFM A;  3EGH A;  3V4Y A;  1S3N A;  1S3L A;  1T70 A;  1HP1 A;  1USH A;  2GJU A;  3H63 A;  5JPE A;  4TUI A;  1HPU A;  3K7V C;  2BCD A;  2IE3 C;  4NZV A;  2P6B A;  4YKE A;  3H67 A;  3N5U A;  4ORB A;  4DT2 A;  3H64 A;  1UF3 A;  2R17 A;  4FBK A;  1M63 A;  4B2O A;  4UT3 A;  4O5G A;  4JA9 A;  3E7B A;  2HYO A;  2HYP A;  1TCO A;  3KBP A;  4KKZ A;  2Q8U A;  1OI8 A;  2USH A;  3H61 A;  1QHW A;  4H2B A;  3LL8 A;  4FBW A; 
#chains in the Genus database with same CATH topology
 4ORA A;  4IYP C;  3P71 C;  3QFK A;  3DW8 C;  4ORC A;  4LTY A;  1UTE A;  1G5B A;  4WWL A;  1AUI A;  4MP0 A;  1IT6 A;  3JYF A;  3EGG A;  2BQ8 X;  2WDF A;  3H66 A;  1XM7 A;  1QFC A;  2QFR A;  1WAR A;  4IL1 A;  3PSO A;  5B8I A;  2WDD A;  4XPN A;  1II7 A;  3C9F A;  2A22 A;  2BDX A;  3CK2 A;  5HPE A;  1Z2W A;  3D03 A;  3H68 A;  4V0V A;  3THN A;  2CV9 A;  5JJT A;  4OR9 A;  3QFO A;  1S8E A;  4H2I A;  3THO B;  3QG5 C;  3IB8 A;  4KBP A;  4Q7F A;  1XZW A;  2IAE C;  2NXF A;  3ICF A;  2XMO A;  1NNW A;  2NYL C;  4FBQ A;  4UWQ A;  1OID A;  2IE4 C;  1S70 A;  2JOG A;  1S95 A;  4DSY A;  2QFP A;  3IVE A;  1OIE A;  2ZO9 B;  1Z2X A;  4ZVZ A;  2HY1 A;  3RL5 A;  3RQZ A;  4TUG A;  3QFN A;  2Z06 A;  2WDE A;  2ZOA A;  2WDC A;  5EQV A;  5DNY A;  2O8A A;  1KBP A;  2O8G A;  4M0V A;  4O24 A;  3HVQ A;  4H2G A;  5INB A;  2DXL A;  4V0X A;  2NPP C;  1U32 A;  3H62 B;  4MOY A;  4UT3 B;  5IOH A;  3H69 A;  2DXN A;  3IVD A;  4JA7 A;  3IB7 A;  3RL4 A;  3E0J A;  4DHL A;  2ZBM A;  5J28 A;  4UT2 A;  2AHD A;  5GTU A;  2NYM C;  2Z1A A;  4LU9 A;  3FLO A;  1SU1 A;  2DFJ A;  3AV0 A;  5JPF A;  1S3M A;  4I5L C;  4G9J A;  3ZTV A;  1JK7 A;  1FJM A;  3FGA C;  3ZU0 A;  2KKN A;  5C1V A;  1MF8 A;  4O43 A;  3H60 A;  3T1I A;  4F0Z A;  3C5W C;  3GVE A;  4LAC C;  3E7A A;  4FCX A;  2QJC A;  1T71 A;  4HD0 A;  4H2F A;  4O4K A;  1V73 A;  5F3W A;  4H1Y P;  4MOV A;  1WAO 1;  3AUZ A;  3DSC A;  4H1S A;  3TGH A;  3K7W C;  4ZX2 A;  4V0W A;  4I5N C;  2YVT A;  1HO5 A;  2Z72 A;  4J6O A;  3RL3 A;  3PSN A;  1W24 A;  3DSD A;  3QFM A;  3EGH A;  3V4Y A;  1S3N A;  1S3L A;  1T70 A;  1HP1 A;  1USH A;  2GJU A;  2YEQ A;  3H63 A;  5JPE A;  1HPU A;  3K7V C;  4TUI A;  2BCD A;  2IE3 C;  4NZV A;  2P6B A;  4YKE A;  3H67 A;  3N5U A;  4ORB A;  4DT2 A;  3H64 A;  1UF3 A;  2R17 A;  4FBK A;  1M63 A;  4B2O A;  4UT3 A;  4O5G A;  4JA9 A;  3E7B A;  2HYO A;  2HYP A;  1TCO A;  3KBP A;  4KKZ A;  2Q8U A;  1OI8 A;  2USH A;  3H61 A;  1QHW A;  4H2B A;  3LL8 A;  4FBW A; 
#chains in the Genus database with same CATH homology
 4ORA A;  4IYP C;  3P71 C;  3QFK A;  3DW8 C;  4ORC A;  4LTY A;  1UTE A;  1G5B A;  4WWL A;  1AUI A;  4MP0 A;  1IT6 A;  3JYF A;  3EGG A;  2BQ8 X;  2WDF A;  3H66 A;  1XM7 A;  1QFC A;  2QFR A;  1WAR A;  4IL1 A;  3PSO A;  5B8I A;  2WDD A;  4XPN A;  1II7 A;  3C9F A;  2A22 A;  2BDX A;  3CK2 A;  5HPE A;  1Z2W A;  3D03 A;  3H68 A;  4V0V A;  3THN A;  2CV9 A;  5JJT A;  4OR9 A;  3QFO A;  1S8E A;  4H2I A;  3THO B;  3QG5 C;  3IB8 A;  4KBP A;  4Q7F A;  1XZW A;  2IAE C;  2NXF A;  3ICF A;  2XMO A;  1NNW A;  2NYL C;  4FBQ A;  4UWQ A;  1OID A;  2IE4 C;  1S70 A;  2JOG A;  1S95 A;  4DSY A;  2QFP A;  3IVE A;  1OIE A;  2ZO9 B;  1Z2X A;  4ZVZ A;  2HY1 A;  3RL5 A;  3RQZ A;  4TUG A;  3QFN A;  2Z06 A;  2WDE A;  2ZOA A;  2WDC A;  5EQV A;  5DNY A;  2O8A A;  1KBP A;  2O8G A;  4M0V A;  4O24 A;  3HVQ A;  4H2G A;  5INB A;  2DXL A;  4V0X A;  2NPP C;  1U32 A;  3H62 B;  4MOY A;  4UT3 B;  5IOH A;  3H69 A;  2DXN A;  3IVD A;  4JA7 A;  3IB7 A;  3RL4 A;  3E0J A;  4DHL A;  2ZBM A;  5J28 A;  4UT2 A;  2AHD A;  5GTU A;  2NYM C;  2Z1A A;  4LU9 A;  3FLO A;  1SU1 A;  2DFJ A;  3AV0 A;  5JPF A;  1S3M A;  4I5L C;  4G9J A;  3ZTV A;  1JK7 A;  1FJM A;  3FGA C;  3ZU0 A;  2KKN A;  5C1V A;  1MF8 A;  4O43 A;  3H60 A;  3T1I A;  4F0Z A;  3C5W C;  3GVE A;  4LAC C;  3E7A A;  4FCX A;  2QJC A;  1T71 A;  4HD0 A;  4H2F A;  4O4K A;  1V73 A;  5F3W A;  4H1Y P;  4MOV A;  1WAO 1;  3AUZ A;  3DSC A;  4H1S A;  3TGH A;  3K7W C;  4ZX2 A;  4V0W A;  4I5N C;  2YVT A;  1HO5 A;  2Z72 A;  4J6O A;  3RL3 A;  3PSN A;  1W24 A;  3DSD A;  3QFM A;  3EGH A;  3V4Y A;  1S3N A;  1S3L A;  1T70 A;  1HP1 A;  1USH A;  2GJU A;  2YEQ A;  3H63 A;  5JPE A;  1HPU A;  3K7V C;  4TUI A;  2BCD A;  2IE3 C;  4NZV A;  2P6B A;  4YKE A;  3H67 A;  3N5U A;  4ORB A;  4DT2 A;  3H64 A;  1UF3 A;  2R17 A;  4FBK A;  1M63 A;  4B2O A;  4UT3 A;  4O5G A;  4JA9 A;  3E7B A;  2HYO A;  2HYP A;  1TCO A;  3KBP A;  4KKZ A;  2Q8U A;  1OI8 A;  2USH A;  3H61 A;  1QHW A;  4H2B A;  3LL8 A;  4FBW A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...