4H2FA

Human ecto-5'-nucleotidase (cd73): crystal form i (open) in complex with adenosine
Total Genus 174
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
174
sequence length
524
structure length
524
Chain Sequence
PWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHADEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTACAVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords 5'-nucleotidase
publication title Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling.
pubmed doi rcsb
source organism Homo sapiens
total genus 174
structure length 524
sequence length 524
ec nomenclature ec 3.1.3.5: 5'-nucleotidase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF02872 5_nucleotid_C 5'-nucleotidase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4h2fA01
3.90.780.10 Alpha Beta Alpha-Beta Complex 5'-nucleotidase; domain 2 5'-Nucleotidase, C-terminal domain 4h2fA02
4F0ZA 4O24A 4V0WA 2Q8UA 3LL8A 3H63A 3PSOA 5B8IA 3C5WC 1UTEA 4FBWA 2WDDA 4DT2A 4UWQA 2JOGA 3P71C 1XM7A 1Z2WA 2BQ8X 1S95A 3K7VC 4H1YP 4O5GA 3RL4A 4OR9A 4ZX2A 3QFKA 4UT3A 4JA7A 1SU1A 4M0VA 2O8GA 1HP1A 4MOYA 1TCOA 3H69A 5JJTA 2YVTA 2NPPC 4J6OA 2BDXA 4KBPA 2HYOA 1S70A 2QFRA 3H62B 4XPNA 3E7BA 3ZU0A 4DHLA 1U32A 3RQZA 2NYMC 3IVEA 4H1SA 1MF8A 1HPUA 4HD0A 4ZVZA 2WDEA 1USHA 4MOVA 4TUIA 1W24A 2HY1A 4FBKA 1WARA 3H64A 3IB8A 1OIEA 3DSDA 4ORAA 3DSCA 4O43A 3IB7A 3IVDA 3K7WC 2Z1AA 2KKNA 4KKZA 4FBQA 3C9FA 3HVQA 4H2IA 4MP0A 5C1VA 4JA9A 5HPEA 2BCDA 3PSNA 1G5BA 2Z72A 1QHWA 3QFMA 3H67A 1XZWA 5JPEA 3E7AA 2Z06A 2P6BA 2IE3C 2GJUA 3THOB 1FJMA 4UT2A 1S3MA 5J28A 4IL1A 4H2FA 3H66A 2WDCA 3JYFA 3H68A 2NYLC 2HYPA 3KBPA 4V0XA 3RL5A 3T1IA 4IYPC 1UF3A 3ICFA 1WAO1 4H2GA 1Z2XA 4ORCA 3EGGA 4LU9A 4V0VA 4YKEA 2DFJA 1S3NA 2CV9A 3DW8C 1T70A 4G9JA 4I5LC 5DNYA 2ZBMA 3THNA 5EQVA 3V4YA 5F3WA 3AUZA 2XMOA 3EGHA 1V73A 1T71A 2R17A 3TGHA 2A22A 3FGAC 4I5NC 4TUGA 2IAEC 2IE4C 2USHA 3ZTVA 1OIDA 4UT3B 4O4KA 4B2OA 5JPFA 2QJCA 4Q7FA 1QFCA 1JK7A 3QG5C 1II7A 4H2BA 1M63A 3H60A 3CK2A 4LACC 5INBA 3GVEA 4ORBA 3QFOA 2O8AA 1HO5A 4LTYA 2WDFA 2QFPA 3RL3A 1KBPA 2NXFA 4NZVA 5IOHA 1IT6A 4FCXA 1AUIA 3H61A 3N5UA 4DSYA 3AV0A 1OI8A 2AHDA 3QFNA 1NNWA 1S8EA 4WWLA 1S3LA 5GTUA
chains in the Genus database with same CATH superfamily
4F0ZA 4O24A 4V0WA 2ZO9B 2Q8UA 3LL8A 3H63A 3PSOA 5B8IA 3C5WC 1UTEA 4FBWA 2WDDA 4DT2A 4UWQA 2JOGA 3P71C 1XM7A 1Z2WA 2BQ8X 1S95A 3K7VC 4H1YP 4O5GA 3RL4A 4OR9A 4ZX2A 3QFKA 4UT3A 4JA7A 1SU1A 4M0VA 2O8GA 1HP1A 4MOYA 1TCOA 3H69A 5JJTA 2YVTA 2ZOAA 2NPPC 4J6OA 2BDXA 4KBPA 2DXNA 2HYOA 1S70A 2QFRA 3H62B 4XPNA 3E7BA 3ZU0A 4DHLA 1U32A 3RQZA 2NYMC 3IVEA 4H1SA 1MF8A 1HPUA 4HD0A 4ZVZA 2WDEA 1USHA 4MOVA 4TUIA 1W24A 2HY1A 4FBKA 1WARA 3H64A 3IB8A 1OIEA 3DSDA 2DXLA 4ORAA 3DSCA 4O43A 3IB7A 3IVDA 3K7WC 2Z1AA 2KKNA 4KKZA 4FBQA 3C9FA 3HVQA 4H2IA 4MP0A 5C1VA 4JA9A 5HPEA 2BCDA 3PSNA 1G5BA 2Z72A 1QHWA 3QFMA 3H67A 1XZWA 5JPEA 3E7AA 2Z06A 2P6BA 2IE3C 2GJUA 3THOB 1FJMA 4UT2A 1S3MA 5J28A 4IL1A 4H2FA 3H66A 2WDCA 3JYFA 3H68A 2NYLC 2HYPA 3KBPA 4V0XA 3RL5A 3T1IA 4IYPC 1UF3A 3ICFA 1WAO1 4H2GA 1Z2XA 4ORCA 3EGGA 4LU9A 4V0VA 4YKEA 2DFJA 1S3NA 2CV9A 3DW8C 1T70A 4G9JA 4I5LC 5DNYA 2ZBMA 3THNA 5EQVA 3V4YA 5F3WA 3AUZA 2XMOA 3EGHA 1V73A 1T71A 2R17A 3TGHA 2A22A 3FGAC 4I5NC 4TUGA 2IAEC 2IE4C 2USHA 3FLOA 1OIDA 4UT3B 4O4KA 3ZTVA 4B2OA 5JPFA 2QJCA 4Q7FA 1QFCA 1JK7A 3QG5C 1II7A 4H2BA 1M63A 3H60A 3CK2A 4LACC 3E0JA 5INBA 2YEQA 3GVEA 4ORBA 3QFOA 2O8AA 1HO5A 4LTYA 2WDFA 2QFPA 3RL3A 1KBPA 2NXFA 4NZVA 5IOHA 1IT6A 3D03A 4FCXA 1AUIA 3H61A 3N5UA 4DSYA 3AV0A 1OI8A 2AHDA 3QFNA 1NNWA 1S8EA 4WWLA 1S3LA 5GTUA
chains in the Genus database with same CATH topology
4F0ZA 4O24A 4V0WA 2ZO9B 2Q8UA 3LL8A 3H63A 3PSOA 5B8IA 3C5WC 1UTEA 4FBWA 2WDDA 4DT2A 4UWQA 2JOGA 3P71C 1XM7A 1Z2WA 2BQ8X 1S95A 3K7VC 4H1YP 4O5GA 3RL4A 4OR9A 4ZX2A 3QFKA 4UT3A 4JA7A 1SU1A 4M0VA 2O8GA 1HP1A 4MOYA 1TCOA 3H69A 5JJTA 2YVTA 2ZOAA 2NPPC 4J6OA 2BDXA 4KBPA 2DXNA 2HYOA 1S70A 2QFRA 3H62B 4XPNA 3E7BA 3ZU0A 4DHLA 1U32A 3RQZA 2NYMC 3IVEA 4H1SA 1MF8A 1HPUA 4HD0A 4ZVZA 2WDEA 1USHA 4MOVA 4TUIA 1W24A 2HY1A 4FBKA 1WARA 3H64A 3IB8A 1OIEA 3DSDA 2DXLA 4ORAA 3DSCA 4O43A 3IB7A 3IVDA 3K7WC 2Z1AA 2KKNA 4KKZA 4FBQA 3C9FA 3HVQA 4H2IA 4MP0A 5C1VA 4JA9A 5HPEA 2BCDA 3PSNA 1G5BA 2Z72A 1QHWA 3QFMA 3H67A 1XZWA 5JPEA 3E7AA 2Z06A 2P6BA 2IE3C 2GJUA 3THOB 1FJMA 4UT2A 1S3MA 5J28A 4IL1A 4H2FA 3H66A 2WDCA 3JYFA 3H68A 2NYLC 2HYPA 3KBPA 4V0XA 3RL5A 3T1IA 4IYPC 1UF3A 3ICFA 1WAO1 4H2GA 1Z2XA 4ORCA 3EGGA 4LU9A 4V0VA 4YKEA 2DFJA 1S3NA 2CV9A 3DW8C 1T70A 4G9JA 4I5LC 5DNYA 2ZBMA 3THNA 5EQVA 3V4YA 5F3WA 3AUZA 2XMOA 3EGHA 1V73A 1T71A 2R17A 3TGHA 2A22A 3FGAC 4I5NC 4TUGA 2IAEC 2IE4C 2USHA 3FLOA 1OIDA 4UT3B 4O4KA 3ZTVA 4B2OA 5JPFA 2QJCA 4Q7FA 1QFCA 1JK7A 3QG5C 1II7A 4H2BA 1M63A 3H60A 3CK2A 4LACC 3E0JA 5INBA 2YEQA 3GVEA 4ORBA 3QFOA 2O8AA 1HO5A 4LTYA 2WDFA 2QFPA 3RL3A 1KBPA 2NXFA 4NZVA 5IOHA 1IT6A 3D03A 4FCXA 1AUIA 3H61A 3N5UA 4DSYA 3AV0A 1OI8A 2AHDA 3QFNA 1NNWA 1S8EA 4WWLA 1S3LA 5GTUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4F0Z A;  4O24 A;  4V0W A;  2Q8U A;  3LL8 A;  3H63 A;  3PSO A;  5B8I A;  3C5W C;  1UTE A;  4FBW A;  2WDD A;  4DT2 A;  4UWQ A;  2JOG A;  3P71 C;  1XM7 A;  1Z2W A;  2BQ8 X;  1S95 A;  3K7V C;  4H1Y P;  4O5G A;  3RL4 A;  4OR9 A;  4ZX2 A;  3QFK A;  4UT3 A;  4JA7 A;  1SU1 A;  4M0V A;  2O8G A;  1HP1 A;  4MOY A;  1TCO A;  3H69 A;  5JJT A;  2YVT A;  2NPP C;  4J6O A;  2BDX A;  4KBP A;  2HYO A;  1S70 A;  2QFR A;  3H62 B;  4XPN A;  3E7B A;  3ZU0 A;  4DHL A;  1U32 A;  3RQZ A;  2NYM C;  3IVE A;  4H1S A;  1MF8 A;  1HPU A;  4HD0 A;  4ZVZ A;  2WDE A;  1USH A;  4MOV A;  4TUI A;  1W24 A;  2HY1 A;  4FBK A;  1WAR A;  3H64 A;  3IB8 A;  1OIE A;  3DSD A;  4ORA A;  3DSC A;  4O43 A;  3IB7 A;  3IVD A;  3K7W C;  2Z1A A;  2KKN A;  4KKZ A;  4FBQ A;  3C9F A;  3HVQ A;  4H2I A;  4MP0 A;  5C1V A;  4JA9 A;  5HPE A;  2BCD A;  3PSN A;  1G5B A;  2Z72 A;  1QHW A;  3QFM A;  3H67 A;  1XZW A;  5JPE A;  3E7A A;  2Z06 A;  2P6B A;  2IE3 C;  2GJU A;  3THO B;  1FJM A;  4UT2 A;  1S3M A;  5J28 A;  4IL1 A;  4H2F A;  3H66 A;  2WDC A;  3JYF A;  3H68 A;  2NYL C;  2HYP A;  3KBP A;  4V0X A;  3RL5 A;  3T1I A;  4IYP C;  1UF3 A;  3ICF A;  1WAO 1;  4H2G A;  1Z2X A;  4ORC A;  3EGG A;  4LU9 A;  4V0V A;  4YKE A;  2DFJ A;  1S3N A;  2CV9 A;  3DW8 C;  1T70 A;  4G9J A;  4I5L C;  5DNY A;  2ZBM A;  3THN A;  5EQV A;  3V4Y A;  5F3W A;  3AUZ A;  2XMO A;  3EGH A;  1V73 A;  1T71 A;  2R17 A;  3TGH A;  2A22 A;  3FGA C;  4I5N C;  4TUG A;  2IAE C;  2IE4 C;  2USH A;  3ZTV A;  1OID A;  4UT3 B;  4O4K A;  4B2O A;  5JPF A;  2QJC A;  4Q7F A;  1QFC A;  1JK7 A;  3QG5 C;  1II7 A;  4H2B A;  1M63 A;  3H60 A;  3CK2 A;  4LAC C;  5INB A;  3GVE A;  4ORB A;  3QFO A;  2O8A A;  1HO5 A;  4LTY A;  2WDF A;  2QFP A;  3RL3 A;  1KBP A;  2NXF A;  4NZV A;  5IOH A;  1IT6 A;  4FCX A;  1AUI A;  3H61 A;  3N5U A;  4DSY A;  3AV0 A;  1OI8 A;  2AHD A;  3QFN A;  1NNW A;  1S8E A;  4WWL A;  1S3L A;  5GTU A; 
#chains in the Genus database with same CATH topology
 4F0Z A;  4O24 A;  4V0W A;  2ZO9 B;  2Q8U A;  3LL8 A;  3H63 A;  3PSO A;  5B8I A;  3C5W C;  1UTE A;  4FBW A;  2WDD A;  4DT2 A;  4UWQ A;  2JOG A;  3P71 C;  1XM7 A;  1Z2W A;  2BQ8 X;  1S95 A;  3K7V C;  4H1Y P;  4O5G A;  3RL4 A;  4OR9 A;  4ZX2 A;  3QFK A;  4UT3 A;  4JA7 A;  1SU1 A;  4M0V A;  2O8G A;  1HP1 A;  4MOY A;  1TCO A;  3H69 A;  5JJT A;  2YVT A;  2ZOA A;  2NPP C;  4J6O A;  2BDX A;  4KBP A;  2DXN A;  2HYO A;  1S70 A;  2QFR A;  3H62 B;  4XPN A;  3E7B A;  3ZU0 A;  4DHL A;  1U32 A;  3RQZ A;  2NYM C;  3IVE A;  4H1S A;  1MF8 A;  1HPU A;  4HD0 A;  4ZVZ A;  2WDE A;  1USH A;  4MOV A;  4TUI A;  1W24 A;  2HY1 A;  4FBK A;  1WAR A;  3H64 A;  3IB8 A;  1OIE A;  3DSD A;  2DXL A;  4ORA A;  3DSC A;  4O43 A;  3IB7 A;  3IVD A;  3K7W C;  2Z1A A;  2KKN A;  4KKZ A;  4FBQ A;  3C9F A;  3HVQ A;  4H2I A;  4MP0 A;  5C1V A;  4JA9 A;  5HPE A;  2BCD A;  3PSN A;  1G5B A;  2Z72 A;  1QHW A;  3QFM A;  3H67 A;  1XZW A;  5JPE A;  3E7A A;  2Z06 A;  2P6B A;  2IE3 C;  2GJU A;  3THO B;  1FJM A;  4UT2 A;  1S3M A;  5J28 A;  4IL1 A;  4H2F A;  3H66 A;  2WDC A;  3JYF A;  3H68 A;  2NYL C;  2HYP A;  3KBP A;  4V0X A;  3RL5 A;  3T1I A;  4IYP C;  1UF3 A;  3ICF A;  1WAO 1;  4H2G A;  1Z2X A;  4ORC A;  3EGG A;  4LU9 A;  4V0V A;  4YKE A;  2DFJ A;  1S3N A;  2CV9 A;  3DW8 C;  1T70 A;  4G9J A;  4I5L C;  5DNY A;  2ZBM A;  3THN A;  5EQV A;  3V4Y A;  5F3W A;  3AUZ A;  2XMO A;  3EGH A;  1V73 A;  1T71 A;  2R17 A;  3TGH A;  2A22 A;  3FGA C;  4I5N C;  4TUG A;  2IAE C;  2IE4 C;  2USH A;  3FLO A;  1OID A;  4UT3 B;  4O4K A;  3ZTV A;  4B2O A;  5JPF A;  2QJC A;  4Q7F A;  1QFC A;  1JK7 A;  3QG5 C;  1II7 A;  4H2B A;  1M63 A;  3H60 A;  3CK2 A;  4LAC C;  3E0J A;  5INB A;  2YEQ A;  3GVE A;  4ORB A;  3QFO A;  2O8A A;  1HO5 A;  4LTY A;  2WDF A;  2QFP A;  3RL3 A;  1KBP A;  2NXF A;  4NZV A;  5IOH A;  1IT6 A;  3D03 A;  4FCX A;  1AUI A;  3H61 A;  3N5U A;  4DSY A;  3AV0 A;  1OI8 A;  2AHD A;  3QFN A;  1NNW A;  1S8E A;  4WWL A;  1S3L A;  5GTU A; 
#chains in the Genus database with same CATH homology
 4F0Z A;  4O24 A;  4V0W A;  2ZO9 B;  2Q8U A;  3LL8 A;  3H63 A;  3PSO A;  5B8I A;  3C5W C;  1UTE A;  4FBW A;  2WDD A;  4DT2 A;  4UWQ A;  2JOG A;  3P71 C;  1XM7 A;  1Z2W A;  2BQ8 X;  1S95 A;  3K7V C;  4H1Y P;  4O5G A;  3RL4 A;  4OR9 A;  4ZX2 A;  3QFK A;  4UT3 A;  4JA7 A;  1SU1 A;  4M0V A;  2O8G A;  1HP1 A;  4MOY A;  1TCO A;  3H69 A;  5JJT A;  2YVT A;  2ZOA A;  2NPP C;  4J6O A;  2BDX A;  4KBP A;  2DXN A;  2HYO A;  1S70 A;  2QFR A;  3H62 B;  4XPN A;  3E7B A;  3ZU0 A;  4DHL A;  1U32 A;  3RQZ A;  2NYM C;  3IVE A;  4H1S A;  1MF8 A;  1HPU A;  4HD0 A;  4ZVZ A;  2WDE A;  1USH A;  4MOV A;  4TUI A;  1W24 A;  2HY1 A;  4FBK A;  1WAR A;  3H64 A;  3IB8 A;  1OIE A;  3DSD A;  2DXL A;  4ORA A;  3DSC A;  4O43 A;  3IB7 A;  3IVD A;  3K7W C;  2Z1A A;  2KKN A;  4KKZ A;  4FBQ A;  3C9F A;  3HVQ A;  4H2I A;  4MP0 A;  5C1V A;  4JA9 A;  5HPE A;  2BCD A;  3PSN A;  1G5B A;  2Z72 A;  1QHW A;  3QFM A;  3H67 A;  1XZW A;  5JPE A;  3E7A A;  2Z06 A;  2P6B A;  2IE3 C;  2GJU A;  3THO B;  1FJM A;  4UT2 A;  1S3M A;  5J28 A;  4IL1 A;  4H2F A;  3H66 A;  2WDC A;  3JYF A;  3H68 A;  2NYL C;  2HYP A;  3KBP A;  4V0X A;  3RL5 A;  3T1I A;  4IYP C;  1UF3 A;  3ICF A;  1WAO 1;  4H2G A;  1Z2X A;  4ORC A;  3EGG A;  4LU9 A;  4V0V A;  4YKE A;  2DFJ A;  1S3N A;  2CV9 A;  3DW8 C;  1T70 A;  4G9J A;  4I5L C;  5DNY A;  2ZBM A;  3THN A;  5EQV A;  3V4Y A;  5F3W A;  3AUZ A;  2XMO A;  3EGH A;  1V73 A;  1T71 A;  2R17 A;  3TGH A;  2A22 A;  3FGA C;  4I5N C;  4TUG A;  2IAE C;  2IE4 C;  2USH A;  3FLO A;  1OID A;  4UT3 B;  4O4K A;  3ZTV A;  4B2O A;  5JPF A;  2QJC A;  4Q7F A;  1QFC A;  1JK7 A;  3QG5 C;  1II7 A;  4H2B A;  1M63 A;  3H60 A;  3CK2 A;  4LAC C;  3E0J A;  5INB A;  2YEQ A;  3GVE A;  4ORB A;  3QFO A;  2O8A A;  1HO5 A;  4LTY A;  2WDF A;  2QFP A;  3RL3 A;  1KBP A;  2NXF A;  4NZV A;  5IOH A;  1IT6 A;  3D03 A;  4FCX A;  1AUI A;  3H61 A;  3N5U A;  4DSY A;  3AV0 A;  1OI8 A;  2AHD A;  3QFN A;  1NNW A;  1S8E A;  4WWL A;  1S3L A;  5GTU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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