4H2FA

Human ecto-5'-nucleotidase (cd73): crystal form i (open) in complex with adenosine
Total Genus 174
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
174
sequence length
524
structure length
524
Chain Sequence
PWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHADEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTACAVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords 5'-nucleotidase
publication title Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 174
structure length 524
sequence length 524
ec nomenclature ec 3.1.3.5: 5'-nucleotidase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF02872 5_nucleotid_C 5'-nucleotidase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4h2fA01
3.90.780.10 Alpha Beta Alpha-Beta Complex 5'-nucleotidase; domain 2 5'-Nucleotidase, C-terminal domain 4h2fA02
2QFPA 3QFOA 3ICFA 3H61A 4H2FA 3RL3A 3RL4A 4Q7FA 2HYOA 3JYFA 3DSCA 4UT2A 1OI8A 2O8GA 2AHDA 1W24A 1S70A 3C9FA 4V0XA 3IB7A 1Z2XA 4FCXA 4JA7A 3V4YA 5JPEA 4H2BA 3H63A 5INBA 2DFJA 1S8EA 1V73A 4FBKA 4ZVZA 3QFMA 1T70A 4B2OA 3E7BA 4XPNA 4O24A 5DNYA 4G9JA 3IVDA 3IVEA 4KKZA 2NYLC 1USHA 2IE3C 2KKNA 2BCDA 1MF8A 3DW8C 4KBPA 3QG5C 3H69A 4MOYA 1OIEA 1T71A 1WARA 3QFKA 5EQVA 1QHWA 4H1YP 4H1SA 4FBWA 4J6OA 1TCOA 4JA9A 2Z06A 3H68A 4LTYA 2BQ8X 4H2IA 4ORBA 2P6BA 2USHA 1OIDA 3THNA 5JJTA 3P71C 2ZBMA 2WDCA 3AV0A 4UWQA 2O8AA 3T1IA 1HP1A 4LU9A 4UT3A 1SU1A 4V0WA 2QJCA 2A22A 3H67A 3E7AA 3THOB 4YKEA 1KBPA 3KBPA 1JK7A 4M0VA 4TUGA 5JPFA 1UTEA 3TGHA 1NNWA 4H2GA 5HPEA 3GVEA 4MOVA 1S95A 5GTUA 3AUZA 3RQZA 2WDDA 3ZTVA 4DT2A 2GJUA 2HYPA 3PSOA 4FBQA 1UF3A 5B8IA 4NZVA 4ORAA 3H62B 3DSDA 4DHLA 1S3LA 2NYMC 2IE4C 4LACC 2XMOA 3CK2A 2WDEA 5IOHA 3LL8A 1FJMA 3QFNA 4DSYA 2BDXA 4OR9A 1Z2WA 2YVTA 3H60A 4O5GA 1HO5A 4WWLA 5J28A 4ZX2A 1HPUA 4ORCA 1II7A 2IAEC 4F0ZA 1QFCA 2Z72A 4I5NC 3C5WC 2WDFA 1XM7A 2Q8UA 3H64A 1S3MA 3IB8A 1G5BA 4HD0A 3FGAC 3EGHA 4MP0A 2NXFA 2Z1AA 2R17A 1AUIA 2QFRA 3EGGA 1IT6A 4O4KA 5C1VA 1WAO1 1S3NA 3H66A 3ZU0A 2JOGA 3K7WC 3K7VC 2HY1A 4V0VA 1XZWA 4IL1A 4I5LC 3HVQA 4O43A 2CV9A 3N5UA 4UT3B 2NPPC 3PSNA 3RL5A 4IYPC 1M63A 1U32A 4TUIA 5F3WA
chains in the Genus database with same CATH superfamily
2QFPA 3QFOA 3ICFA 3H61A 4H2FA 3RL3A 3RL4A 4Q7FA 2HYOA 3JYFA 3DSCA 4UT2A 1OI8A 2O8GA 2AHDA 1W24A 1S70A 3C9FA 4V0XA 3IB7A 1Z2XA 4FCXA 4JA7A 3V4YA 5JPEA 4H2BA 3H63A 5INBA 2DFJA 1S8EA 3ZU0A 1V73A 4FBKA 4ZVZA 3QFMA 1T70A 4B2OA 3E7BA 4XPNA 4O24A 5DNYA 4G9JA 3IVDA 3IVEA 4KKZA 2NYLC 1USHA 2IE3C 2KKNA 2BCDA 1MF8A 3DW8C 4KBPA 3QG5C 3H69A 4MOYA 1OIEA 3E0JA 1T71A 1WARA 3QFKA 5EQVA 1QHWA 4H1YP 4H1SA 4FBWA 4J6OA 1TCOA 4JA9A 2Z06A 3H68A 4LTYA 2BQ8X 4H2IA 4ORBA 2P6BA 2USHA 1OIDA 3THNA 5JJTA 3P71C 2ZBMA 2ZO9B 3D03A 2WDCA 3AV0A 4UWQA 2O8AA 3T1IA 1HP1A 4LU9A 4UT3A 2YEQA 1SU1A 4V0WA 2QJCA 2A22A 3H67A 3E7AA 3THOB 4YKEA 1KBPA 3KBPA 1JK7A 4M0VA 4TUGA 2DXLA 5JPFA 1UTEA 3TGHA 1NNWA 4H2GA 5HPEA 3GVEA 4MOVA 1S95A 5GTUA 3AUZA 3RQZA 2WDDA 3ZTVA 4DT2A 2GJUA 2HYPA 3PSOA 4FBQA 1UF3A 5B8IA 4NZVA 4ORAA 3H62B 3DSDA 3FLOA 4DHLA 1S3LA 2NYMC 2IE4C 4LACC 2XMOA 3CK2A 2WDEA 5IOHA 3LL8A 1FJMA 3QFNA 4DSYA 2BDXA 4OR9A 1Z2WA 2YVTA 3H60A 4O5GA 1HO5A 4WWLA 5J28A 4ZX2A 1HPUA 4ORCA 1II7A 2IAEC 4F0ZA 1QFCA 2Z72A 4I5NC 3C5WC 2WDFA 1XM7A 2Q8UA 3H64A 1S3MA 3IB8A 1G5BA 4HD0A 3FGAC 3EGHA 4MP0A 2NXFA 2Z1AA 2DXNA 2R17A 1AUIA 2QFRA 3EGGA 1IT6A 4O4KA 5C1VA 1WAO1 1S3NA 2ZOAA 3H66A 2JOGA 3K7WC 3K7VC 2HY1A 4V0VA 1XZWA 4IL1A 4I5LC 3HVQA 4O43A 2CV9A 3N5UA 4UT3B 2NPPC 3PSNA 3RL5A 4IYPC 1M63A 1U32A 4TUIA 5F3WA
chains in the Genus database with same CATH topology
2QFPA 3QFOA 3ICFA 3H61A 4H2FA 3RL3A 3RL4A 4Q7FA 2HYOA 3JYFA 3DSCA 4UT2A 1OI8A 2O8GA 2AHDA 1W24A 1S70A 3C9FA 4V0XA 3IB7A 1Z2XA 4FCXA 4JA7A 3V4YA 5JPEA 4H2BA 3H63A 5INBA 2DFJA 1S8EA 3ZU0A 1V73A 4FBKA 4ZVZA 3QFMA 1T70A 4B2OA 3E7BA 4XPNA 4O24A 5DNYA 4G9JA 3IVDA 3IVEA 4KKZA 2NYLC 1USHA 2IE3C 2KKNA 2BCDA 1MF8A 3DW8C 4KBPA 3QG5C 3H69A 4MOYA 1OIEA 3E0JA 1T71A 1WARA 3QFKA 5EQVA 1QHWA 4H1YP 4H1SA 4FBWA 4J6OA 1TCOA 4JA9A 2Z06A 3H68A 4LTYA 2BQ8X 4H2IA 4ORBA 2P6BA 2USHA 1OIDA 3THNA 5JJTA 3P71C 2ZBMA 2ZO9B 3D03A 2WDCA 3AV0A 4UWQA 2O8AA 3T1IA 1HP1A 4LU9A 4UT3A 2YEQA 1SU1A 4V0WA 2QJCA 2A22A 3H67A 3E7AA 3THOB 4YKEA 1KBPA 3KBPA 1JK7A 4M0VA 4TUGA 2DXLA 5JPFA 1UTEA 3TGHA 1NNWA 4H2GA 5HPEA 3GVEA 4MOVA 1S95A 5GTUA 3AUZA 3RQZA 2WDDA 3ZTVA 4DT2A 2GJUA 2HYPA 3PSOA 4FBQA 1UF3A 5B8IA 4NZVA 4ORAA 3H62B 3DSDA 3FLOA 4DHLA 1S3LA 2NYMC 2IE4C 4LACC 2XMOA 3CK2A 2WDEA 5IOHA 3LL8A 1FJMA 3QFNA 4DSYA 2BDXA 4OR9A 1Z2WA 2YVTA 3H60A 4O5GA 1HO5A 4WWLA 5J28A 4ZX2A 1HPUA 4ORCA 1II7A 2IAEC 4F0ZA 1QFCA 2Z72A 4I5NC 3C5WC 2WDFA 1XM7A 2Q8UA 3H64A 1S3MA 3IB8A 1G5BA 4HD0A 3FGAC 3EGHA 4MP0A 2NXFA 2Z1AA 2DXNA 2R17A 1AUIA 2QFRA 3EGGA 1IT6A 4O4KA 5C1VA 1WAO1 1S3NA 2ZOAA 3H66A 2JOGA 3K7WC 3K7VC 2HY1A 4V0VA 1XZWA 4IL1A 4I5LC 3HVQA 4O43A 2CV9A 3N5UA 4UT3B 2NPPC 3PSNA 3RL5A 4IYPC 1M63A 1U32A 4TUIA 5F3WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QFP A;  3QFO A;  3ICF A;  3H61 A;  4H2F A;  3RL3 A;  3RL4 A;  4Q7F A;  2HYO A;  3JYF A;  3DSC A;  4UT2 A;  1OI8 A;  2O8G A;  2AHD A;  1W24 A;  1S70 A;  3C9F A;  4V0X A;  3IB7 A;  1Z2X A;  4FCX A;  4JA7 A;  3V4Y A;  5JPE A;  4H2B A;  3H63 A;  5INB A;  2DFJ A;  1S8E A;  1V73 A;  4FBK A;  4ZVZ A;  3QFM A;  1T70 A;  4B2O A;  3E7B A;  4XPN A;  4O24 A;  5DNY A;  4G9J A;  3IVD A;  3IVE A;  4KKZ A;  2NYL C;  1USH A;  2IE3 C;  2KKN A;  2BCD A;  1MF8 A;  3DW8 C;  4KBP A;  3QG5 C;  3H69 A;  4MOY A;  1OIE A;  1T71 A;  1WAR A;  3QFK A;  5EQV A;  1QHW A;  4H1Y P;  4H1S A;  4FBW A;  4J6O A;  1TCO A;  4JA9 A;  2Z06 A;  3H68 A;  4LTY A;  2BQ8 X;  4H2I A;  4ORB A;  2P6B A;  2USH A;  1OID A;  3THN A;  5JJT A;  3P71 C;  2ZBM A;  2WDC A;  3AV0 A;  4UWQ A;  2O8A A;  3T1I A;  1HP1 A;  4LU9 A;  4UT3 A;  1SU1 A;  4V0W A;  2QJC A;  2A22 A;  3H67 A;  3E7A A;  3THO B;  4YKE A;  1KBP A;  3KBP A;  1JK7 A;  4M0V A;  4TUG A;  5JPF A;  1UTE A;  3TGH A;  1NNW A;  4H2G A;  5HPE A;  3GVE A;  4MOV A;  1S95 A;  5GTU A;  3AUZ A;  3RQZ A;  2WDD A;  3ZTV A;  4DT2 A;  2GJU A;  2HYP A;  3PSO A;  4FBQ A;  1UF3 A;  5B8I A;  4NZV A;  4ORA A;  3H62 B;  3DSD A;  4DHL A;  1S3L A;  2NYM C;  2IE4 C;  4LAC C;  2XMO A;  3CK2 A;  2WDE A;  5IOH A;  3LL8 A;  1FJM A;  3QFN A;  4DSY A;  2BDX A;  4OR9 A;  1Z2W A;  2YVT A;  3H60 A;  4O5G A;  1HO5 A;  4WWL A;  5J28 A;  4ZX2 A;  1HPU A;  4ORC A;  1II7 A;  2IAE C;  4F0Z A;  1QFC A;  2Z72 A;  4I5N C;  3C5W C;  2WDF A;  1XM7 A;  2Q8U A;  3H64 A;  1S3M A;  3IB8 A;  1G5B A;  4HD0 A;  3FGA C;  3EGH A;  4MP0 A;  2NXF A;  2Z1A A;  2R17 A;  1AUI A;  2QFR A;  3EGG A;  1IT6 A;  4O4K A;  5C1V A;  1WAO 1;  1S3N A;  3H66 A;  3ZU0 A;  2JOG A;  3K7W C;  3K7V C;  2HY1 A;  4V0V A;  1XZW A;  4IL1 A;  4I5L C;  3HVQ A;  4O43 A;  2CV9 A;  3N5U A;  4UT3 B;  2NPP C;  3PSN A;  3RL5 A;  4IYP C;  1M63 A;  1U32 A;  4TUI A;  5F3W A; 
#chains in the Genus database with same CATH topology
 2QFP A;  3QFO A;  3ICF A;  3H61 A;  4H2F A;  3RL3 A;  3RL4 A;  4Q7F A;  2HYO A;  3JYF A;  3DSC A;  4UT2 A;  1OI8 A;  2O8G A;  2AHD A;  1W24 A;  1S70 A;  3C9F A;  4V0X A;  3IB7 A;  1Z2X A;  4FCX A;  4JA7 A;  3V4Y A;  5JPE A;  4H2B A;  3H63 A;  5INB A;  2DFJ A;  1S8E A;  3ZU0 A;  1V73 A;  4FBK A;  4ZVZ A;  3QFM A;  1T70 A;  4B2O A;  3E7B A;  4XPN A;  4O24 A;  5DNY A;  4G9J A;  3IVD A;  3IVE A;  4KKZ A;  2NYL C;  1USH A;  2IE3 C;  2KKN A;  2BCD A;  1MF8 A;  3DW8 C;  4KBP A;  3QG5 C;  3H69 A;  4MOY A;  1OIE A;  3E0J A;  1T71 A;  1WAR A;  3QFK A;  5EQV A;  1QHW A;  4H1Y P;  4H1S A;  4FBW A;  4J6O A;  1TCO A;  4JA9 A;  2Z06 A;  3H68 A;  4LTY A;  2BQ8 X;  4H2I A;  4ORB A;  2P6B A;  2USH A;  1OID A;  3THN A;  5JJT A;  3P71 C;  2ZBM A;  2ZO9 B;  3D03 A;  2WDC A;  3AV0 A;  4UWQ A;  2O8A A;  3T1I A;  1HP1 A;  4LU9 A;  4UT3 A;  2YEQ A;  1SU1 A;  4V0W A;  2QJC A;  2A22 A;  3H67 A;  3E7A A;  3THO B;  4YKE A;  1KBP A;  3KBP A;  1JK7 A;  4M0V A;  4TUG A;  2DXL A;  5JPF A;  1UTE A;  3TGH A;  1NNW A;  4H2G A;  5HPE A;  3GVE A;  4MOV A;  1S95 A;  5GTU A;  3AUZ A;  3RQZ A;  2WDD A;  3ZTV A;  4DT2 A;  2GJU A;  2HYP A;  3PSO A;  4FBQ A;  1UF3 A;  5B8I A;  4NZV A;  4ORA A;  3H62 B;  3DSD A;  3FLO A;  4DHL A;  1S3L A;  2NYM C;  2IE4 C;  4LAC C;  2XMO A;  3CK2 A;  2WDE A;  5IOH A;  3LL8 A;  1FJM A;  3QFN A;  4DSY A;  2BDX A;  4OR9 A;  1Z2W A;  2YVT A;  3H60 A;  4O5G A;  1HO5 A;  4WWL A;  5J28 A;  4ZX2 A;  1HPU A;  4ORC A;  1II7 A;  2IAE C;  4F0Z A;  1QFC A;  2Z72 A;  4I5N C;  3C5W C;  2WDF A;  1XM7 A;  2Q8U A;  3H64 A;  1S3M A;  3IB8 A;  1G5B A;  4HD0 A;  3FGA C;  3EGH A;  4MP0 A;  2NXF A;  2Z1A A;  2DXN A;  2R17 A;  1AUI A;  2QFR A;  3EGG A;  1IT6 A;  4O4K A;  5C1V A;  1WAO 1;  1S3N A;  2ZOA A;  3H66 A;  2JOG A;  3K7W C;  3K7V C;  2HY1 A;  4V0V A;  1XZW A;  4IL1 A;  4I5L C;  3HVQ A;  4O43 A;  2CV9 A;  3N5U A;  4UT3 B;  2NPP C;  3PSN A;  3RL5 A;  4IYP C;  1M63 A;  1U32 A;  4TUI A;  5F3W A; 
#chains in the Genus database with same CATH homology
 2QFP A;  3QFO A;  3ICF A;  3H61 A;  4H2F A;  3RL3 A;  3RL4 A;  4Q7F A;  2HYO A;  3JYF A;  3DSC A;  4UT2 A;  1OI8 A;  2O8G A;  2AHD A;  1W24 A;  1S70 A;  3C9F A;  4V0X A;  3IB7 A;  1Z2X A;  4FCX A;  4JA7 A;  3V4Y A;  5JPE A;  4H2B A;  3H63 A;  5INB A;  2DFJ A;  1S8E A;  3ZU0 A;  1V73 A;  4FBK A;  4ZVZ A;  3QFM A;  1T70 A;  4B2O A;  3E7B A;  4XPN A;  4O24 A;  5DNY A;  4G9J A;  3IVD A;  3IVE A;  4KKZ A;  2NYL C;  1USH A;  2IE3 C;  2KKN A;  2BCD A;  1MF8 A;  3DW8 C;  4KBP A;  3QG5 C;  3H69 A;  4MOY A;  1OIE A;  3E0J A;  1T71 A;  1WAR A;  3QFK A;  5EQV A;  1QHW A;  4H1Y P;  4H1S A;  4FBW A;  4J6O A;  1TCO A;  4JA9 A;  2Z06 A;  3H68 A;  4LTY A;  2BQ8 X;  4H2I A;  4ORB A;  2P6B A;  2USH A;  1OID A;  3THN A;  5JJT A;  3P71 C;  2ZBM A;  2ZO9 B;  3D03 A;  2WDC A;  3AV0 A;  4UWQ A;  2O8A A;  3T1I A;  1HP1 A;  4LU9 A;  4UT3 A;  2YEQ A;  1SU1 A;  4V0W A;  2QJC A;  2A22 A;  3H67 A;  3E7A A;  3THO B;  4YKE A;  1KBP A;  3KBP A;  1JK7 A;  4M0V A;  4TUG A;  2DXL A;  5JPF A;  1UTE A;  3TGH A;  1NNW A;  4H2G A;  5HPE A;  3GVE A;  4MOV A;  1S95 A;  5GTU A;  3AUZ A;  3RQZ A;  2WDD A;  3ZTV A;  4DT2 A;  2GJU A;  2HYP A;  3PSO A;  4FBQ A;  1UF3 A;  5B8I A;  4NZV A;  4ORA A;  3H62 B;  3DSD A;  3FLO A;  4DHL A;  1S3L A;  2NYM C;  2IE4 C;  4LAC C;  2XMO A;  3CK2 A;  2WDE A;  5IOH A;  3LL8 A;  1FJM A;  3QFN A;  4DSY A;  2BDX A;  4OR9 A;  1Z2W A;  2YVT A;  3H60 A;  4O5G A;  1HO5 A;  4WWL A;  5J28 A;  4ZX2 A;  1HPU A;  4ORC A;  1II7 A;  2IAE C;  4F0Z A;  1QFC A;  2Z72 A;  4I5N C;  3C5W C;  2WDF A;  1XM7 A;  2Q8U A;  3H64 A;  1S3M A;  3IB8 A;  1G5B A;  4HD0 A;  3FGA C;  3EGH A;  4MP0 A;  2NXF A;  2Z1A A;  2DXN A;  2R17 A;  1AUI A;  2QFR A;  3EGG A;  1IT6 A;  4O4K A;  5C1V A;  1WAO 1;  1S3N A;  2ZOA A;  3H66 A;  2JOG A;  3K7W C;  3K7V C;  2HY1 A;  4V0V A;  1XZW A;  4IL1 A;  4I5L C;  3HVQ A;  4O43 A;  2CV9 A;  3N5U A;  4UT3 B;  2NPP C;  3PSN A;  3RL5 A;  4IYP C;  1M63 A;  1U32 A;  4TUI A;  5F3W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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