4H2FA

Human ecto-5'-nucleotidase (cd73): crystal form i (open) in complex with adenosine
Total Genus 174
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
174
sequence length
524
structure length
524
Chain Sequence
PWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHADEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTACAVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords 5'-nucleotidase
total genus 174
structure length 524
sequence length 524
ec nomenclature ec 3.1.3.5: 5'-nucleotidase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF02872 5_nucleotid_C 5'-nucleotidase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4h2fA01
3.90.780.10 Alpha Beta Alpha-Beta Complex 5'-nucleotidase; domain 2 5'-Nucleotidase, C-terminal domain 4h2fA02
2BDXA 4KKZA 3E7AA 2HYOA 4V0VA 1Z2XA 4XPNA 3DSDA 4MOVA 4IL1A 3T1IA 2ZBMA 5B8IA 4O43A 2NXFA 3H66A 3EGGA 4ORCA 2Z1AA 3N5UA 2YVTA 2WDEA 4KBPA 4ORAA 2QFPA 1XZWA 3QFNA 3IB7A 2QJCA 4IYPC 2BCDA 1S3NA 3GVEA 1HO5A 3EGHA 3AV0A 4FCXA 3QFKA 3H61A 4ZX2A 3IB8A 4H2IA 4MOYA 2AHDA 1KBPA 1JK7A 4J6OA 5INBA 3TGHA 1HPUA 3RL3A 2HY1A 2A22A 2WDCA 1T71A 3RL4A 1QFCA 1OI8A 3PSNA 2NPPC 4M0VA 3E7BA 5DNYA 3H63A 3H67A 2Q8UA 1USHA 5HPEA 4F0ZA 4O5GA 3HVQA 2IE3C 3QFMA 4G9JA 4JA9A 4Q7FA 3QG5C 1S3MA 4ZVZA 4H2GA 3CK2A 1M63A 2O8GA 4LU9A 4V0WA 4DHLA 4H2BA 1T70A 4H2FA 3H62B 4LACC 3ZTVA 4DT2A 3V4YA 1MF8A 3C5WC 2BQ8X 3KBPA 4JA7A 3IVDA 2XMOA 5F3WA 2GJUA 3H69A 4H1SA 1UF3A 4O4KA 4MP0A 4UT2A 4O24A 5JPEA 1TCOA 1UTEA 3K7WC 1HP1A 3LL8A 4V0XA 1OIEA 1QHWA 3DSCA 1OIDA 2JOGA 3C9FA 2Z06A 4LTYA 3THOB 3QFOA 3RL5A 2CV9A 1SU1A 3RQZA 3AUZA 4WWLA 3H64A 1NNWA 4DSYA 1II7A 1S3LA 2P6BA 5J28A 2R17A 3ZU0A 3FGAC 3P71C 2KKNA 4HD0A 2NYMC 4I5NC 4UT3A 1WAO1 4FBQA 3DW8C 2WDDA 4I5LC 3IVEA 1W24A 2IE4C 5GTUA 5JPFA 2HYPA 4B2OA 1U32A 2O8AA 4UT3B 2USHA 1FJMA 3JYFA 5EQVA 2IAEC 1WARA 5IOHA 2NYLC 4ORBA 3ICFA 5JJTA 4TUGA 2Z72A 2WDFA 4TUIA 4YKEA 3H60A 1S70A 1XM7A 2DFJA 4NZVA 1G5BA 4FBWA 2QFRA 4UWQA 3H68A 4FBKA 1AUIA 4H1YP 3THNA 3K7VC 1S95A 4OR9A 5C1VA 3PSOA 1IT6A 1V73A 1S8EA 1Z2WA
chains in the Genus database with same CATH superfamily
2BDXA 4KKZA 2YEQA 3E7AA 2HYOA 4V0VA 1Z2XA 4XPNA 3DSDA 4MOVA 4IL1A 3T1IA 2ZBMA 5B8IA 2DXLA 4O43A 2NXFA 3H66A 3EGGA 4ORCA 2Z1AA 3N5UA 2YVTA 2WDEA 4KBPA 4ORAA 2QFPA 1XZWA 3QFNA 3IB7A 2QJCA 2ZOAA 4IYPC 2BCDA 1S3NA 3GVEA 2DXNA 1HO5A 3EGHA 3AV0A 4FCXA 3QFKA 3H61A 4ZX2A 3IB8A 4H2IA 4MOYA 2AHDA 1KBPA 1JK7A 4J6OA 5INBA 3TGHA 1HPUA 3RL3A 2HY1A 2A22A 2WDCA 1T71A 3RL4A 1QFCA 1OI8A 3PSNA 2NPPC 4M0VA 3E7BA 5DNYA 3H63A 3H67A 2Q8UA 1USHA 5HPEA 4F0ZA 4O5GA 3HVQA 2IE3C 3QFMA 4G9JA 4JA9A 4Q7FA 3QG5C 1S3MA 4ZVZA 4H2GA 3CK2A 1M63A 2O8GA 4LU9A 4V0WA 4DHLA 4H2BA 1T70A 4H2FA 3H62B 4LACC 3ZTVA 4DT2A 3V4YA 1MF8A 3C5WC 2BQ8X 3KBPA 4JA7A 3IVDA 2XMOA 5F3WA 2GJUA 3H69A 4H1SA 1UF3A 4O4KA 4MP0A 4UT2A 4O24A 5JPEA 1TCOA 1UTEA 3K7WC 1HP1A 3LL8A 4V0XA 1OIEA 1QHWA 3D03A 3DSCA 1OIDA 2JOGA 3C9FA 2Z06A 4LTYA 3THOB 3QFOA 3RL5A 2CV9A 1SU1A 3RQZA 3AUZA 4WWLA 3H64A 1NNWA 4DSYA 1II7A 1S3LA 2P6BA 5J28A 2R17A 3ZU0A 3FGAC 3P71C 2KKNA 4HD0A 2NYMC 4I5NC 4UT3A 1WAO1 4FBQA 3DW8C 2WDDA 3FLOA 3IVEA 1W24A 2IE4C 4I5LC 5GTUA 5JPFA 2HYPA 4B2OA 1U32A 3E0JA 2O8AA 4UT3B 2USHA 1FJMA 3JYFA 5EQVA 2IAEC 1WARA 5IOHA 2NYLC 4ORBA 3ICFA 5JJTA 4TUGA 2Z72A 2ZO9B 2WDFA 4TUIA 4YKEA 3H60A 1S70A 1XM7A 2DFJA 4NZVA 1G5BA 4FBWA 2QFRA 4UWQA 3H68A 4FBKA 1AUIA 4H1YP 3THNA 3K7VC 1S95A 4OR9A 5C1VA 3PSOA 1IT6A 1V73A 1S8EA 1Z2WA
chains in the Genus database with same CATH topology
2BDXA 4KKZA 2YEQA 3E7AA 2HYOA 4V0VA 1Z2XA 4XPNA 3DSDA 4MOVA 4IL1A 3T1IA 2ZBMA 5B8IA 2DXLA 4O43A 2NXFA 3H66A 3EGGA 4ORCA 2Z1AA 3N5UA 2YVTA 2WDEA 4KBPA 4ORAA 2QFPA 1XZWA 3QFNA 3IB7A 2QJCA 2ZOAA 4IYPC 2BCDA 1S3NA 3GVEA 2DXNA 1HO5A 3EGHA 3AV0A 4FCXA 3QFKA 3H61A 4ZX2A 3IB8A 4H2IA 4MOYA 2AHDA 1KBPA 1JK7A 4J6OA 5INBA 3TGHA 1HPUA 3RL3A 2HY1A 2A22A 2WDCA 1T71A 3RL4A 1QFCA 1OI8A 3PSNA 2NPPC 4M0VA 3E7BA 5DNYA 3H63A 3H67A 2Q8UA 1USHA 5HPEA 4F0ZA 4O5GA 3HVQA 2IE3C 3QFMA 4G9JA 4JA9A 4Q7FA 3QG5C 1S3MA 4ZVZA 4H2GA 3CK2A 1M63A 2O8GA 4LU9A 4V0WA 4DHLA 4H2BA 1T70A 4H2FA 3H62B 4LACC 3ZTVA 4DT2A 3V4YA 1MF8A 3C5WC 2BQ8X 3KBPA 4JA7A 3IVDA 2XMOA 5F3WA 2GJUA 3H69A 4H1SA 1UF3A 4O4KA 4MP0A 4UT2A 4O24A 5JPEA 1TCOA 1UTEA 3K7WC 1HP1A 3LL8A 4V0XA 1OIEA 1QHWA 3D03A 3DSCA 1OIDA 2JOGA 3C9FA 2Z06A 4LTYA 3THOB 3QFOA 3RL5A 2CV9A 1SU1A 3RQZA 3AUZA 4WWLA 3H64A 1NNWA 4DSYA 1II7A 1S3LA 2P6BA 5J28A 2R17A 3ZU0A 3FGAC 3P71C 2KKNA 4HD0A 2NYMC 4I5NC 4UT3A 1WAO1 4FBQA 3DW8C 2WDDA 3FLOA 3IVEA 1W24A 2IE4C 4I5LC 5GTUA 5JPFA 2HYPA 4B2OA 1U32A 3E0JA 2O8AA 4UT3B 2USHA 1FJMA 3JYFA 5EQVA 2IAEC 1WARA 5IOHA 2NYLC 4ORBA 3ICFA 5JJTA 4TUGA 2Z72A 2ZO9B 2WDFA 4TUIA 4YKEA 3H60A 1S70A 1XM7A 2DFJA 4NZVA 1G5BA 4FBWA 2QFRA 4UWQA 3H68A 4FBKA 1AUIA 4H1YP 3THNA 3K7VC 1S95A 4OR9A 5C1VA 3PSOA 1IT6A 1V73A 1S8EA 1Z2WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BDX A;  4KKZ A;  3E7A A;  2HYO A;  4V0V A;  1Z2X A;  4XPN A;  3DSD A;  4MOV A;  4IL1 A;  3T1I A;  2ZBM A;  5B8I A;  4O43 A;  2NXF A;  3H66 A;  3EGG A;  4ORC A;  2Z1A A;  3N5U A;  2YVT A;  2WDE A;  4KBP A;  4ORA A;  2QFP A;  1XZW A;  3QFN A;  3IB7 A;  2QJC A;  4IYP C;  2BCD A;  1S3N A;  3GVE A;  1HO5 A;  3EGH A;  3AV0 A;  4FCX A;  3QFK A;  3H61 A;  4ZX2 A;  3IB8 A;  4H2I A;  4MOY A;  2AHD A;  1KBP A;  1JK7 A;  4J6O A;  5INB A;  3TGH A;  1HPU A;  3RL3 A;  2HY1 A;  2A22 A;  2WDC A;  1T71 A;  3RL4 A;  1QFC A;  1OI8 A;  3PSN A;  2NPP C;  4M0V A;  3E7B A;  5DNY A;  3H63 A;  3H67 A;  2Q8U A;  1USH A;  5HPE A;  4F0Z A;  4O5G A;  3HVQ A;  2IE3 C;  3QFM A;  4G9J A;  4JA9 A;  4Q7F A;  3QG5 C;  1S3M A;  4ZVZ A;  4H2G A;  3CK2 A;  1M63 A;  2O8G A;  4LU9 A;  4V0W A;  4DHL A;  4H2B A;  1T70 A;  4H2F A;  3H62 B;  4LAC C;  3ZTV A;  4DT2 A;  3V4Y A;  1MF8 A;  3C5W C;  2BQ8 X;  3KBP A;  4JA7 A;  3IVD A;  2XMO A;  5F3W A;  2GJU A;  3H69 A;  4H1S A;  1UF3 A;  4O4K A;  4MP0 A;  4UT2 A;  4O24 A;  5JPE A;  1TCO A;  1UTE A;  3K7W C;  1HP1 A;  3LL8 A;  4V0X A;  1OIE A;  1QHW A;  3DSC A;  1OID A;  2JOG A;  3C9F A;  2Z06 A;  4LTY A;  3THO B;  3QFO A;  3RL5 A;  2CV9 A;  1SU1 A;  3RQZ A;  3AUZ A;  4WWL A;  3H64 A;  1NNW A;  4DSY A;  1II7 A;  1S3L A;  2P6B A;  5J28 A;  2R17 A;  3ZU0 A;  3FGA C;  3P71 C;  2KKN A;  4HD0 A;  2NYM C;  4I5N C;  4UT3 A;  1WAO 1;  4FBQ A;  3DW8 C;  2WDD A;  4I5L C;  3IVE A;  1W24 A;  2IE4 C;  5GTU A;  5JPF A;  2HYP A;  4B2O A;  1U32 A;  2O8A A;  4UT3 B;  2USH A;  1FJM A;  3JYF A;  5EQV A;  2IAE C;  1WAR A;  5IOH A;  2NYL C;  4ORB A;  3ICF A;  5JJT A;  4TUG A;  2Z72 A;  2WDF A;  4TUI A;  4YKE A;  3H60 A;  1S70 A;  1XM7 A;  2DFJ A;  4NZV A;  1G5B A;  4FBW A;  2QFR A;  4UWQ A;  3H68 A;  4FBK A;  1AUI A;  4H1Y P;  3THN A;  3K7V C;  1S95 A;  4OR9 A;  5C1V A;  3PSO A;  1IT6 A;  1V73 A;  1S8E A;  1Z2W A; 
#chains in the Genus database with same CATH topology
 2BDX A;  4KKZ A;  2YEQ A;  3E7A A;  2HYO A;  4V0V A;  1Z2X A;  4XPN A;  3DSD A;  4MOV A;  4IL1 A;  3T1I A;  2ZBM A;  5B8I A;  2DXL A;  4O43 A;  2NXF A;  3H66 A;  3EGG A;  4ORC A;  2Z1A A;  3N5U A;  2YVT A;  2WDE A;  4KBP A;  4ORA A;  2QFP A;  1XZW A;  3QFN A;  3IB7 A;  2QJC A;  2ZOA A;  4IYP C;  2BCD A;  1S3N A;  3GVE A;  2DXN A;  1HO5 A;  3EGH A;  3AV0 A;  4FCX A;  3QFK A;  3H61 A;  4ZX2 A;  3IB8 A;  4H2I A;  4MOY A;  2AHD A;  1KBP A;  1JK7 A;  4J6O A;  5INB A;  3TGH A;  1HPU A;  3RL3 A;  2HY1 A;  2A22 A;  2WDC A;  1T71 A;  3RL4 A;  1QFC A;  1OI8 A;  3PSN A;  2NPP C;  4M0V A;  3E7B A;  5DNY A;  3H63 A;  3H67 A;  2Q8U A;  1USH A;  5HPE A;  4F0Z A;  4O5G A;  3HVQ A;  2IE3 C;  3QFM A;  4G9J A;  4JA9 A;  4Q7F A;  3QG5 C;  1S3M A;  4ZVZ A;  4H2G A;  3CK2 A;  1M63 A;  2O8G A;  4LU9 A;  4V0W A;  4DHL A;  4H2B A;  1T70 A;  4H2F A;  3H62 B;  4LAC C;  3ZTV A;  4DT2 A;  3V4Y A;  1MF8 A;  3C5W C;  2BQ8 X;  3KBP A;  4JA7 A;  3IVD A;  2XMO A;  5F3W A;  2GJU A;  3H69 A;  4H1S A;  1UF3 A;  4O4K A;  4MP0 A;  4UT2 A;  4O24 A;  5JPE A;  1TCO A;  1UTE A;  3K7W C;  1HP1 A;  3LL8 A;  4V0X A;  1OIE A;  1QHW A;  3D03 A;  3DSC A;  1OID A;  2JOG A;  3C9F A;  2Z06 A;  4LTY A;  3THO B;  3QFO A;  3RL5 A;  2CV9 A;  1SU1 A;  3RQZ A;  3AUZ A;  4WWL A;  3H64 A;  1NNW A;  4DSY A;  1II7 A;  1S3L A;  2P6B A;  5J28 A;  2R17 A;  3ZU0 A;  3FGA C;  3P71 C;  2KKN A;  4HD0 A;  2NYM C;  4I5N C;  4UT3 A;  1WAO 1;  4FBQ A;  3DW8 C;  2WDD A;  3FLO A;  3IVE A;  1W24 A;  2IE4 C;  4I5L C;  5GTU A;  5JPF A;  2HYP A;  4B2O A;  1U32 A;  3E0J A;  2O8A A;  4UT3 B;  2USH A;  1FJM A;  3JYF A;  5EQV A;  2IAE C;  1WAR A;  5IOH A;  2NYL C;  4ORB A;  3ICF A;  5JJT A;  4TUG A;  2Z72 A;  2ZO9 B;  2WDF A;  4TUI A;  4YKE A;  3H60 A;  1S70 A;  1XM7 A;  2DFJ A;  4NZV A;  1G5B A;  4FBW A;  2QFR A;  4UWQ A;  3H68 A;  4FBK A;  1AUI A;  4H1Y P;  3THN A;  3K7V C;  1S95 A;  4OR9 A;  5C1V A;  3PSO A;  1IT6 A;  1V73 A;  1S8E A;  1Z2W A; 
#chains in the Genus database with same CATH homology
 2BDX A;  4KKZ A;  2YEQ A;  3E7A A;  2HYO A;  4V0V A;  1Z2X A;  4XPN A;  3DSD A;  4MOV A;  4IL1 A;  3T1I A;  2ZBM A;  5B8I A;  2DXL A;  4O43 A;  2NXF A;  3H66 A;  3EGG A;  4ORC A;  2Z1A A;  3N5U A;  2YVT A;  2WDE A;  4KBP A;  4ORA A;  2QFP A;  1XZW A;  3QFN A;  3IB7 A;  2QJC A;  2ZOA A;  4IYP C;  2BCD A;  1S3N A;  3GVE A;  2DXN A;  1HO5 A;  3EGH A;  3AV0 A;  4FCX A;  3QFK A;  3H61 A;  4ZX2 A;  3IB8 A;  4H2I A;  4MOY A;  2AHD A;  1KBP A;  1JK7 A;  4J6O A;  5INB A;  3TGH A;  1HPU A;  3RL3 A;  2HY1 A;  2A22 A;  2WDC A;  1T71 A;  3RL4 A;  1QFC A;  1OI8 A;  3PSN A;  2NPP C;  4M0V A;  3E7B A;  5DNY A;  3H63 A;  3H67 A;  2Q8U A;  1USH A;  5HPE A;  4F0Z A;  4O5G A;  3HVQ A;  2IE3 C;  3QFM A;  4G9J A;  4JA9 A;  4Q7F A;  3QG5 C;  1S3M A;  4ZVZ A;  4H2G A;  3CK2 A;  1M63 A;  2O8G A;  4LU9 A;  4V0W A;  4DHL A;  4H2B A;  1T70 A;  4H2F A;  3H62 B;  4LAC C;  3ZTV A;  4DT2 A;  3V4Y A;  1MF8 A;  3C5W C;  2BQ8 X;  3KBP A;  4JA7 A;  3IVD A;  2XMO A;  5F3W A;  2GJU A;  3H69 A;  4H1S A;  1UF3 A;  4O4K A;  4MP0 A;  4UT2 A;  4O24 A;  5JPE A;  1TCO A;  1UTE A;  3K7W C;  1HP1 A;  3LL8 A;  4V0X A;  1OIE A;  1QHW A;  3D03 A;  3DSC A;  1OID A;  2JOG A;  3C9F A;  2Z06 A;  4LTY A;  3THO B;  3QFO A;  3RL5 A;  2CV9 A;  1SU1 A;  3RQZ A;  3AUZ A;  4WWL A;  3H64 A;  1NNW A;  4DSY A;  1II7 A;  1S3L A;  2P6B A;  5J28 A;  2R17 A;  3ZU0 A;  3FGA C;  3P71 C;  2KKN A;  4HD0 A;  2NYM C;  4I5N C;  4UT3 A;  1WAO 1;  4FBQ A;  3DW8 C;  2WDD A;  3FLO A;  3IVE A;  1W24 A;  2IE4 C;  4I5L C;  5GTU A;  5JPF A;  2HYP A;  4B2O A;  1U32 A;  3E0J A;  2O8A A;  4UT3 B;  2USH A;  1FJM A;  3JYF A;  5EQV A;  2IAE C;  1WAR A;  5IOH A;  2NYL C;  4ORB A;  3ICF A;  5JJT A;  4TUG A;  2Z72 A;  2ZO9 B;  2WDF A;  4TUI A;  4YKE A;  3H60 A;  1S70 A;  1XM7 A;  2DFJ A;  4NZV A;  1G5B A;  4FBW A;  2QFR A;  4UWQ A;  3H68 A;  4FBK A;  1AUI A;  4H1Y P;  3THN A;  3K7V C;  1S95 A;  4OR9 A;  5C1V A;  3PSO A;  1IT6 A;  1V73 A;  1S8E A;  1Z2W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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