4H2BA

Human ecto-5'-nucleotidase (cd73): crystal form ii (open) in complex with baicalin
Total Genus 187
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
187
sequence length
524
structure length
524
Chain Sequence
PWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANISASGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHADEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTSCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords 5'-nucleotidase
total genus 187
structure length 524
sequence length 524
ec nomenclature ec 3.1.3.5: 5'-nucleotidase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF02872 5_nucleotid_C 5'-nucleotidase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4h2bA01
3.90.780.10 Alpha Beta Alpha-Beta Complex 5'-nucleotidase; domain 2 5'-Nucleotidase, C-terminal domain 4h2bA02
1UF3A 4J6OA 1S3NA 4UT3A 2NYMC 1HO5A 2BQ8X 1KBPA 2YVTA 3DW8C 4XPNA 4TUIA 4ORAA 1T71A 5IOHA 1HPUA 4FBQA 4G9JA 1OIDA 3H67A 2AHDA 4YKEA 4UT2A 3CK2A 4LU9A 1T70A 2KKNA 4H1SA 3H63A 4DSYA 5INBA 2IE3C 3RL3A 4UT3B 3EGHA 5J28A 4ORBA 4IYPC 3THNA 1IT6A 1W24A 3HVQA 2NXFA 3H69A 2HY1A 3QFOA 3TGHA 2HYPA 2WDFA 4LTYA 1XZWA 1U32A 2WDCA 4H2IA 1QHWA 1S3LA 1V73A 3QFKA 3T1IA 3ZU0A 4DT2A 3H62B 1Z2WA 4V0WA 3IVEA 4ORCA 2DFJA 4F0ZA 4OR9A 4MOYA 4MOVA 2WDDA 4WWLA 3H68A 2QFPA 3GVEA 2QFRA 4HD0A 4ZX2A 2ZBMA 4IL1A 4LACC 2O8GA 4JA9A 4NZVA 1Z2XA 4O24A 3H64A 1TCOA 3P71C 1JK7A 4KKZA 5C1VA 3IB7A 3AUZA 4DHLA 1AUIA 1NNWA 3FGAC 1XM7A 5JPFA 1S70A 3JYFA 4Q7FA 2CV9A 3DSDA 3IB8A 5F3WA 3E7AA 3E7BA 4H2FA 4B2OA 2WDEA 2O8AA 3QG5C 2BDXA 2JOGA 4FBWA 3C5WC 3H61A 4O43A 1SU1A 4I5NC 1OI8A 2XMOA 3K7VC 2A22A 2IAEC 4FBKA 5EQVA 4H2GA 4KBPA 3RQZA 1S8EA 4O5GA 2Q8UA 3IVDA 5GTUA 5HPEA 2Z1AA 1WARA 1OIEA 3V4YA 4V0XA 4H1YP 3AV0A 2USHA 3H60A 2Z72A 2HYOA 2IE4C 1FJMA 3C9FA 2QJCA 1HP1A 3PSOA 3K7WC 2BCDA 1QFCA 3EGGA 4MP0A 2NYLC 4H2BA 3N5UA 4JA7A 3THOB 4M0VA 1S3MA 5DNYA 3ZTVA 3LL8A 4O4KA 1II7A 1S95A 3QFMA 3DSCA 3PSNA 2NPPC 4I5LC 5JPEA 2Z06A 1USHA 3RL5A 2R17A 1M63A 4V0VA 3QFNA 4TUGA 1G5BA 3H66A 2P6BA 1WAO1 3ICFA 4FCXA 5B8IA 1MF8A 2GJUA 5JJTA 3RL4A 3KBPA 4UWQA 1UTEA 4ZVZA
chains in the Genus database with same CATH superfamily
1UF3A 4J6OA 1S3NA 4UT3A 2NYMC 1HO5A 2BQ8X 1KBPA 2ZO9B 2YVTA 3DW8C 4XPNA 4TUIA 4ORAA 1T71A 5IOHA 1HPUA 4FBQA 3FLOA 4G9JA 1OIDA 3H67A 2AHDA 2ZOAA 4YKEA 4UT2A 3CK2A 4LU9A 1T70A 2KKNA 4H1SA 2DXLA 3H63A 4DSYA 5INBA 2IE3C 3RL3A 4UT3B 3EGHA 5J28A 4ORBA 4IYPC 3THNA 1IT6A 1W24A 3HVQA 2NXFA 3H69A 2HY1A 3QFOA 3TGHA 2HYPA 2WDFA 4LTYA 1XZWA 1U32A 2WDCA 4H2IA 1QHWA 1S3LA 1V73A 3QFKA 3T1IA 3ZU0A 4DT2A 3H62B 1Z2WA 4V0WA 3IVEA 4ORCA 2DFJA 4F0ZA 4OR9A 4MOYA 4MOVA 2WDDA 4WWLA 3H68A 2QFPA 3GVEA 2QFRA 4HD0A 4ZX2A 2ZBMA 4IL1A 4LACC 2O8GA 4JA9A 4NZVA 1Z2XA 4O24A 3H64A 1TCOA 3P71C 1JK7A 4KKZA 5C1VA 3IB7A 3AUZA 4DHLA 1AUIA 1NNWA 3FGAC 1XM7A 5JPFA 1S70A 3JYFA 4Q7FA 2CV9A 3DSDA 3E0JA 3IB8A 5F3WA 3E7AA 3E7BA 4H2FA 4B2OA 2WDEA 2O8AA 3QG5C 2BDXA 2JOGA 4FBWA 3C5WC 3H61A 4O43A 1SU1A 4I5NC 1OI8A 2XMOA 3K7VC 2A22A 2IAEC 4FBKA 5EQVA 4H2GA 4KBPA 3RQZA 1S8EA 4O5GA 2Q8UA 3IVDA 5GTUA 5HPEA 2Z1AA 1WARA 1OIEA 3V4YA 4V0XA 4H1YP 3AV0A 2USHA 3H60A 2Z72A 2HYOA 2IE4C 1FJMA 3C9FA 2QJCA 1HP1A 3PSOA 3K7WC 2BCDA 1QFCA 2DXNA 3EGGA 2YEQA 4MP0A 2NYLC 4H2BA 3N5UA 4JA7A 3THOB 4M0VA 1S3MA 5DNYA 3ZTVA 3LL8A 4O4KA 1II7A 1S95A 3QFMA 3DSCA 3PSNA 2NPPC 4I5LC 5JPEA 2Z06A 1USHA 3RL5A 2R17A 1M63A 4V0VA 3QFNA 4TUGA 1G5BA 3H66A 2P6BA 1WAO1 3ICFA 4FCXA 5B8IA 1MF8A 2GJUA 5JJTA 3RL4A 3KBPA 4UWQA 1UTEA 3D03A 4ZVZA
chains in the Genus database with same CATH topology
1UF3A 4J6OA 1S3NA 4UT3A 2NYMC 1HO5A 2BQ8X 1KBPA 2ZO9B 2YVTA 3DW8C 4XPNA 4TUIA 4ORAA 1T71A 5IOHA 1HPUA 4FBQA 3FLOA 4G9JA 1OIDA 3H67A 2AHDA 2ZOAA 4YKEA 4UT2A 3CK2A 4LU9A 1T70A 2KKNA 4H1SA 2DXLA 3H63A 4DSYA 5INBA 2IE3C 3RL3A 4UT3B 3EGHA 5J28A 4ORBA 4IYPC 3THNA 1IT6A 1W24A 3HVQA 2NXFA 3H69A 2HY1A 3QFOA 3TGHA 2HYPA 2WDFA 4LTYA 1XZWA 1U32A 2WDCA 4H2IA 1QHWA 1S3LA 1V73A 3QFKA 3T1IA 3ZU0A 4DT2A 3H62B 1Z2WA 4V0WA 3IVEA 4ORCA 2DFJA 4F0ZA 4OR9A 4MOYA 4MOVA 2WDDA 4WWLA 3H68A 2QFPA 3GVEA 2QFRA 4HD0A 4ZX2A 2ZBMA 4IL1A 4LACC 2O8GA 4JA9A 4NZVA 1Z2XA 4O24A 3H64A 1TCOA 3P71C 1JK7A 4KKZA 5C1VA 3IB7A 3AUZA 4DHLA 1AUIA 1NNWA 3FGAC 1XM7A 5JPFA 1S70A 3JYFA 4Q7FA 2CV9A 3DSDA 3E0JA 3IB8A 5F3WA 3E7AA 3E7BA 4H2FA 4B2OA 2WDEA 2O8AA 3QG5C 2BDXA 2JOGA 4FBWA 3C5WC 3H61A 4O43A 1SU1A 4I5NC 1OI8A 2XMOA 3K7VC 2A22A 2IAEC 4FBKA 5EQVA 4H2GA 4KBPA 3RQZA 1S8EA 4O5GA 2Q8UA 3IVDA 5GTUA 5HPEA 2Z1AA 1WARA 1OIEA 3V4YA 4V0XA 4H1YP 3AV0A 2USHA 3H60A 2Z72A 2HYOA 2IE4C 1FJMA 3C9FA 2QJCA 1HP1A 3PSOA 3K7WC 2BCDA 1QFCA 2DXNA 3EGGA 2YEQA 4MP0A 2NYLC 4H2BA 3N5UA 4JA7A 3THOB 4M0VA 1S3MA 5DNYA 3ZTVA 3LL8A 4O4KA 1II7A 1S95A 3QFMA 3DSCA 3PSNA 2NPPC 4I5LC 5JPEA 2Z06A 1USHA 3RL5A 2R17A 1M63A 4V0VA 3QFNA 4TUGA 1G5BA 3H66A 2P6BA 1WAO1 3ICFA 4FCXA 5B8IA 1MF8A 2GJUA 5JJTA 3RL4A 3KBPA 4UWQA 1UTEA 3D03A 4ZVZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1UF3 A;  4J6O A;  1S3N A;  4UT3 A;  2NYM C;  1HO5 A;  2BQ8 X;  1KBP A;  2YVT A;  3DW8 C;  4XPN A;  4TUI A;  4ORA A;  1T71 A;  5IOH A;  1HPU A;  4FBQ A;  4G9J A;  1OID A;  3H67 A;  2AHD A;  4YKE A;  4UT2 A;  3CK2 A;  4LU9 A;  1T70 A;  2KKN A;  4H1S A;  3H63 A;  4DSY A;  5INB A;  2IE3 C;  3RL3 A;  4UT3 B;  3EGH A;  5J28 A;  4ORB A;  4IYP C;  3THN A;  1IT6 A;  1W24 A;  3HVQ A;  2NXF A;  3H69 A;  2HY1 A;  3QFO A;  3TGH A;  2HYP A;  2WDF A;  4LTY A;  1XZW A;  1U32 A;  2WDC A;  4H2I A;  1QHW A;  1S3L A;  1V73 A;  3QFK A;  3T1I A;  3ZU0 A;  4DT2 A;  3H62 B;  1Z2W A;  4V0W A;  3IVE A;  4ORC A;  2DFJ A;  4F0Z A;  4OR9 A;  4MOY A;  4MOV A;  2WDD A;  4WWL A;  3H68 A;  2QFP A;  3GVE A;  2QFR A;  4HD0 A;  4ZX2 A;  2ZBM A;  4IL1 A;  4LAC C;  2O8G A;  4JA9 A;  4NZV A;  1Z2X A;  4O24 A;  3H64 A;  1TCO A;  3P71 C;  1JK7 A;  4KKZ A;  5C1V A;  3IB7 A;  3AUZ A;  4DHL A;  1AUI A;  1NNW A;  3FGA C;  1XM7 A;  5JPF A;  1S70 A;  3JYF A;  4Q7F A;  2CV9 A;  3DSD A;  3IB8 A;  5F3W A;  3E7A A;  3E7B A;  4H2F A;  4B2O A;  2WDE A;  2O8A A;  3QG5 C;  2BDX A;  2JOG A;  4FBW A;  3C5W C;  3H61 A;  4O43 A;  1SU1 A;  4I5N C;  1OI8 A;  2XMO A;  3K7V C;  2A22 A;  2IAE C;  4FBK A;  5EQV A;  4H2G A;  4KBP A;  3RQZ A;  1S8E A;  4O5G A;  2Q8U A;  3IVD A;  5GTU A;  5HPE A;  2Z1A A;  1WAR A;  1OIE A;  3V4Y A;  4V0X A;  4H1Y P;  3AV0 A;  2USH A;  3H60 A;  2Z72 A;  2HYO A;  2IE4 C;  1FJM A;  3C9F A;  2QJC A;  1HP1 A;  3PSO A;  3K7W C;  2BCD A;  1QFC A;  3EGG A;  4MP0 A;  2NYL C;  4H2B A;  3N5U A;  4JA7 A;  3THO B;  4M0V A;  1S3M A;  5DNY A;  3ZTV A;  3LL8 A;  4O4K A;  1II7 A;  1S95 A;  3QFM A;  3DSC A;  3PSN A;  2NPP C;  4I5L C;  5JPE A;  2Z06 A;  1USH A;  3RL5 A;  2R17 A;  1M63 A;  4V0V A;  3QFN A;  4TUG A;  1G5B A;  3H66 A;  2P6B A;  1WAO 1;  3ICF A;  4FCX A;  5B8I A;  1MF8 A;  2GJU A;  5JJT A;  3RL4 A;  3KBP A;  4UWQ A;  1UTE A;  4ZVZ A; 
#chains in the Genus database with same CATH topology
 1UF3 A;  4J6O A;  1S3N A;  4UT3 A;  2NYM C;  1HO5 A;  2BQ8 X;  1KBP A;  2ZO9 B;  2YVT A;  3DW8 C;  4XPN A;  4TUI A;  4ORA A;  1T71 A;  5IOH A;  1HPU A;  4FBQ A;  3FLO A;  4G9J A;  1OID A;  3H67 A;  2AHD A;  2ZOA A;  4YKE A;  4UT2 A;  3CK2 A;  4LU9 A;  1T70 A;  2KKN A;  4H1S A;  2DXL A;  3H63 A;  4DSY A;  5INB A;  2IE3 C;  3RL3 A;  4UT3 B;  3EGH A;  5J28 A;  4ORB A;  4IYP C;  3THN A;  1IT6 A;  1W24 A;  3HVQ A;  2NXF A;  3H69 A;  2HY1 A;  3QFO A;  3TGH A;  2HYP A;  2WDF A;  4LTY A;  1XZW A;  1U32 A;  2WDC A;  4H2I A;  1QHW A;  1S3L A;  1V73 A;  3QFK A;  3T1I A;  3ZU0 A;  4DT2 A;  3H62 B;  1Z2W A;  4V0W A;  3IVE A;  4ORC A;  2DFJ A;  4F0Z A;  4OR9 A;  4MOY A;  4MOV A;  2WDD A;  4WWL A;  3H68 A;  2QFP A;  3GVE A;  2QFR A;  4HD0 A;  4ZX2 A;  2ZBM A;  4IL1 A;  4LAC C;  2O8G A;  4JA9 A;  4NZV A;  1Z2X A;  4O24 A;  3H64 A;  1TCO A;  3P71 C;  1JK7 A;  4KKZ A;  5C1V A;  3IB7 A;  3AUZ A;  4DHL A;  1AUI A;  1NNW A;  3FGA C;  1XM7 A;  5JPF A;  1S70 A;  3JYF A;  4Q7F A;  2CV9 A;  3DSD A;  3E0J A;  3IB8 A;  5F3W A;  3E7A A;  3E7B A;  4H2F A;  4B2O A;  2WDE A;  2O8A A;  3QG5 C;  2BDX A;  2JOG A;  4FBW A;  3C5W C;  3H61 A;  4O43 A;  1SU1 A;  4I5N C;  1OI8 A;  2XMO A;  3K7V C;  2A22 A;  2IAE C;  4FBK A;  5EQV A;  4H2G A;  4KBP A;  3RQZ A;  1S8E A;  4O5G A;  2Q8U A;  3IVD A;  5GTU A;  5HPE A;  2Z1A A;  1WAR A;  1OIE A;  3V4Y A;  4V0X A;  4H1Y P;  3AV0 A;  2USH A;  3H60 A;  2Z72 A;  2HYO A;  2IE4 C;  1FJM A;  3C9F A;  2QJC A;  1HP1 A;  3PSO A;  3K7W C;  2BCD A;  1QFC A;  2DXN A;  3EGG A;  2YEQ A;  4MP0 A;  2NYL C;  4H2B A;  3N5U A;  4JA7 A;  3THO B;  4M0V A;  1S3M A;  5DNY A;  3ZTV A;  3LL8 A;  4O4K A;  1II7 A;  1S95 A;  3QFM A;  3DSC A;  3PSN A;  2NPP C;  4I5L C;  5JPE A;  2Z06 A;  1USH A;  3RL5 A;  2R17 A;  1M63 A;  4V0V A;  3QFN A;  4TUG A;  1G5B A;  3H66 A;  2P6B A;  1WAO 1;  3ICF A;  4FCX A;  5B8I A;  1MF8 A;  2GJU A;  5JJT A;  3RL4 A;  3KBP A;  4UWQ A;  1UTE A;  3D03 A;  4ZVZ A; 
#chains in the Genus database with same CATH homology
 1UF3 A;  4J6O A;  1S3N A;  4UT3 A;  2NYM C;  1HO5 A;  2BQ8 X;  1KBP A;  2ZO9 B;  2YVT A;  3DW8 C;  4XPN A;  4TUI A;  4ORA A;  1T71 A;  5IOH A;  1HPU A;  4FBQ A;  3FLO A;  4G9J A;  1OID A;  3H67 A;  2AHD A;  2ZOA A;  4YKE A;  4UT2 A;  3CK2 A;  4LU9 A;  1T70 A;  2KKN A;  4H1S A;  2DXL A;  3H63 A;  4DSY A;  5INB A;  2IE3 C;  3RL3 A;  4UT3 B;  3EGH A;  5J28 A;  4ORB A;  4IYP C;  3THN A;  1IT6 A;  1W24 A;  3HVQ A;  2NXF A;  3H69 A;  2HY1 A;  3QFO A;  3TGH A;  2HYP A;  2WDF A;  4LTY A;  1XZW A;  1U32 A;  2WDC A;  4H2I A;  1QHW A;  1S3L A;  1V73 A;  3QFK A;  3T1I A;  3ZU0 A;  4DT2 A;  3H62 B;  1Z2W A;  4V0W A;  3IVE A;  4ORC A;  2DFJ A;  4F0Z A;  4OR9 A;  4MOY A;  4MOV A;  2WDD A;  4WWL A;  3H68 A;  2QFP A;  3GVE A;  2QFR A;  4HD0 A;  4ZX2 A;  2ZBM A;  4IL1 A;  4LAC C;  2O8G A;  4JA9 A;  4NZV A;  1Z2X A;  4O24 A;  3H64 A;  1TCO A;  3P71 C;  1JK7 A;  4KKZ A;  5C1V A;  3IB7 A;  3AUZ A;  4DHL A;  1AUI A;  1NNW A;  3FGA C;  1XM7 A;  5JPF A;  1S70 A;  3JYF A;  4Q7F A;  2CV9 A;  3DSD A;  3E0J A;  3IB8 A;  5F3W A;  3E7A A;  3E7B A;  4H2F A;  4B2O A;  2WDE A;  2O8A A;  3QG5 C;  2BDX A;  2JOG A;  4FBW A;  3C5W C;  3H61 A;  4O43 A;  1SU1 A;  4I5N C;  1OI8 A;  2XMO A;  3K7V C;  2A22 A;  2IAE C;  4FBK A;  5EQV A;  4H2G A;  4KBP A;  3RQZ A;  1S8E A;  4O5G A;  2Q8U A;  3IVD A;  5GTU A;  5HPE A;  2Z1A A;  1WAR A;  1OIE A;  3V4Y A;  4V0X A;  4H1Y P;  3AV0 A;  2USH A;  3H60 A;  2Z72 A;  2HYO A;  2IE4 C;  1FJM A;  3C9F A;  2QJC A;  1HP1 A;  3PSO A;  3K7W C;  2BCD A;  1QFC A;  2DXN A;  3EGG A;  2YEQ A;  4MP0 A;  2NYL C;  4H2B A;  3N5U A;  4JA7 A;  3THO B;  4M0V A;  1S3M A;  5DNY A;  3ZTV A;  3LL8 A;  4O4K A;  1II7 A;  1S95 A;  3QFM A;  3DSC A;  3PSN A;  2NPP C;  4I5L C;  5JPE A;  2Z06 A;  1USH A;  3RL5 A;  2R17 A;  1M63 A;  4V0V A;  3QFN A;  4TUG A;  1G5B A;  3H66 A;  2P6B A;  1WAO 1;  3ICF A;  4FCX A;  5B8I A;  1MF8 A;  2GJU A;  5JJT A;  3RL4 A;  3KBP A;  4UWQ A;  1UTE A;  3D03 A;  4ZVZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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