4H2BA

Human ecto-5'-nucleotidase (cd73): crystal form ii (open) in complex with baicalin
Total Genus 187
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
187
sequence length
524
structure length
524
Chain Sequence
PWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANISASGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHADEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTSCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords 5'-nucleotidase
total genus 187
structure length 524
sequence length 524
ec nomenclature ec 3.1.3.5: 5'-nucleotidase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF02872 5_nucleotid_C 5'-nucleotidase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4h2bA01
3.90.780.10 Alpha Beta Alpha-Beta Complex 5'-nucleotidase; domain 2 5'-Nucleotidase, C-terminal domain 4h2bA02
3IVEA 4O4KA 5C1VA 1UTEA 1S95A 1WAO1 3V4YA 3N5UA 3C9FA 2Z06A 1QFCA 2IAEC 2WDDA 3QFNA 3AUZA 3TGHA 4O24A 2IE3C 3AV0A 4UWQA 3H62B 1HO5A 4LACC 2O8AA 3ICFA 4YKEA 2WDFA 5HPEA 5IOHA 3CK2A 1V73A 3H66A 4H2FA 5EQVA 5F3WA 1Z2WA 1UF3A 4V0VA 2Z72A 3H60A 1HPUA 4ZX2A 5DNYA 5GTUA 4TUGA 4O43A 2XMOA 2QFPA 4O5GA 5JPEA 2QFRA 3HVQA 4V0XA 4MP0A 3H63A 3RL3A 3RQZA 2NXFA 1S3LA 2O8GA 4LU9A 3DSDA 2DFJA 2AHDA 2IE4C 4ORCA 3T1IA 4MOYA 4OR9A 3QFKA 3PSOA 4NZVA 4LTYA 3RL4A 2NPPC 3QFMA 4H1SA 4V0WA 4KKZA 2KKNA 3K7WC 4FBQA 3ZTVA 4JA7A 4B2OA 4JA9A 3E7BA 3JYFA 1HP1A 1USHA 3C5WC 3DSCA 2QJCA 4ORAA 3ZU0A 3H61A 1II7A 3KBPA 4FBWA 4UT2A 3EGHA 4H1YP 1S3MA 4HD0A 1FJMA 3DW8C 4IYPC 4IL1A 1OI8A 4UT3A 4F0ZA 1JK7A 2A22A 1MF8A 1XM7A 1T70A 3H64A 3E7AA 3PSNA 2WDEA 4KBPA 2NYMC 4FCXA 2Z1AA 1Z2XA 4Q7FA 4H2IA 3IB8A 3THNA 3H69A 1TCOA 2R17A 3GVEA 1NNWA 4DT2A 1QHWA 4XPNA 3IVDA 5JPFA 4ORBA 2GJUA 3IB7A 3P71C 2BQ8X 4WWLA 1SU1A 1T71A 4TUIA 1WARA 1IT6A 4DHLA 1S8EA 1KBPA 1XZWA 2USHA 5B8IA 2BCDA 5J28A 2HYOA 4H2BA 4ZVZA 1S70A 1S3NA 1U32A 2WDCA 3K7VC 4I5NC 3H68A 4I5LC 2CV9A 1OIEA 2HYPA 3QG5C 4UT3B 2JOGA 2ZBMA 1AUIA 4G9JA 4DSYA 4MOVA 1M63A 2HY1A 2P6BA 4FBKA 5JJTA 3QFOA 3THOB 3H67A 3RL5A 4H2GA 3EGGA 3LL8A 4J6OA 2NYLC 2Q8UA 2YVTA 5INBA 3FGAC 2BDXA 1G5BA 1OIDA 4M0VA 1W24A
chains in the Genus database with same CATH superfamily
3IVEA 4O4KA 5C1VA 1UTEA 1S95A 1WAO1 3V4YA 3N5UA 3C9FA 2Z06A 1QFCA 2IAEC 2WDDA 3QFNA 3AUZA 3TGHA 4O24A 2IE3C 3AV0A 4UWQA 3H62B 1HO5A 4LACC 2O8AA 3ICFA 4YKEA 2WDFA 5HPEA 5IOHA 3CK2A 1V73A 3H66A 4H2FA 5EQVA 5F3WA 1Z2WA 1UF3A 4V0VA 2Z72A 3H60A 1HPUA 4ZX2A 5DNYA 5GTUA 4TUGA 4O43A 3E0JA 2XMOA 2QFPA 4O5GA 5JPEA 2QFRA 3HVQA 4V0XA 4MP0A 3H63A 3RL3A 3RQZA 2NXFA 1S3LA 2O8GA 4LU9A 3DSDA 2DXLA 2DFJA 2AHDA 2IE4C 4ORCA 3T1IA 4MOYA 4OR9A 3QFKA 3PSOA 4NZVA 4LTYA 3RL4A 2NPPC 3QFMA 4H1SA 4V0WA 4KKZA 2KKNA 3K7WC 4FBQA 3ZTVA 4JA7A 4B2OA 4JA9A 3E7BA 3JYFA 1HP1A 1USHA 3C5WC 3DSCA 2QJCA 4ORAA 3ZU0A 3H61A 1II7A 3KBPA 4FBWA 4UT2A 3EGHA 4H1YP 1S3MA 4HD0A 1FJMA 3DW8C 4IYPC 4IL1A 1OI8A 4UT3A 4F0ZA 1JK7A 2A22A 1MF8A 2ZOAA 1XM7A 1T70A 3H64A 3E7AA 3PSNA 2WDEA 4KBPA 2NYMC 4FCXA 2DXNA 2Z1AA 1Z2XA 4Q7FA 4H2IA 3IB8A 3THNA 3H69A 1TCOA 2R17A 3GVEA 1NNWA 4DT2A 1QHWA 4XPNA 3IVDA 5JPFA 4ORBA 2GJUA 3IB7A 3P71C 2BQ8X 4WWLA 2YEQA 1SU1A 1T71A 4TUIA 1WARA 1IT6A 4DHLA 1S8EA 1KBPA 1XZWA 2USHA 5B8IA 2BCDA 5J28A 2HYOA 4H2BA 4ZVZA 1S70A 2ZO9B 3D03A 1S3NA 2WDCA 1U32A 3K7VC 4I5NC 3H68A 4I5LC 2CV9A 1OIEA 2HYPA 3FLOA 3QG5C 2JOGA 4UT3B 2ZBMA 1AUIA 4G9JA 4DSYA 4MOVA 1M63A 2HY1A 2P6BA 4FBKA 5JJTA 3QFOA 3THOB 3H67A 3RL5A 4H2GA 3EGGA 3LL8A 4J6OA 2NYLC 2Q8UA 2YVTA 5INBA 3FGAC 2BDXA 1G5BA 1OIDA 4M0VA 1W24A
chains in the Genus database with same CATH topology
3IVEA 4O4KA 5C1VA 1UTEA 1S95A 1WAO1 3V4YA 3N5UA 3C9FA 2Z06A 1QFCA 2IAEC 2WDDA 3QFNA 3AUZA 3TGHA 4O24A 2IE3C 3AV0A 4UWQA 3H62B 1HO5A 4LACC 2O8AA 3ICFA 4YKEA 2WDFA 5HPEA 5IOHA 3CK2A 1V73A 3H66A 4H2FA 5EQVA 5F3WA 1Z2WA 1UF3A 4V0VA 2Z72A 3H60A 1HPUA 4ZX2A 5DNYA 5GTUA 4TUGA 4O43A 3E0JA 2XMOA 2QFPA 4O5GA 5JPEA 2QFRA 3HVQA 4V0XA 4MP0A 3H63A 3RL3A 3RQZA 2NXFA 1S3LA 2O8GA 4LU9A 3DSDA 2DXLA 2DFJA 2AHDA 2IE4C 4ORCA 3T1IA 4MOYA 4OR9A 3QFKA 3PSOA 4NZVA 4LTYA 3RL4A 2NPPC 3QFMA 4H1SA 4V0WA 4KKZA 2KKNA 3K7WC 4FBQA 3ZTVA 4JA7A 4B2OA 4JA9A 3E7BA 3JYFA 1HP1A 1USHA 3C5WC 3DSCA 2QJCA 4ORAA 3ZU0A 3H61A 1II7A 3KBPA 4FBWA 4UT2A 3EGHA 4H1YP 1S3MA 4HD0A 1FJMA 3DW8C 4IYPC 4IL1A 1OI8A 4UT3A 4F0ZA 1JK7A 2A22A 1MF8A 2ZOAA 1XM7A 1T70A 3H64A 3E7AA 3PSNA 2WDEA 4KBPA 2NYMC 4FCXA 2DXNA 2Z1AA 1Z2XA 4Q7FA 4H2IA 3IB8A 3THNA 3H69A 1TCOA 2R17A 3GVEA 1NNWA 4DT2A 1QHWA 4XPNA 3IVDA 5JPFA 4ORBA 2GJUA 3IB7A 3P71C 2BQ8X 4WWLA 2YEQA 1SU1A 1T71A 4TUIA 1WARA 1IT6A 4DHLA 1S8EA 1KBPA 1XZWA 2USHA 5B8IA 2BCDA 5J28A 2HYOA 4H2BA 4ZVZA 1S70A 2ZO9B 3D03A 1S3NA 2WDCA 1U32A 3K7VC 4I5NC 3H68A 4I5LC 2CV9A 1OIEA 2HYPA 3FLOA 3QG5C 2JOGA 4UT3B 2ZBMA 1AUIA 4G9JA 4DSYA 4MOVA 1M63A 2HY1A 2P6BA 4FBKA 5JJTA 3QFOA 3THOB 3H67A 3RL5A 4H2GA 3EGGA 3LL8A 4J6OA 2NYLC 2Q8UA 2YVTA 5INBA 3FGAC 2BDXA 1G5BA 1OIDA 4M0VA 1W24A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IVE A;  4O4K A;  5C1V A;  1UTE A;  1S95 A;  1WAO 1;  3V4Y A;  3N5U A;  3C9F A;  2Z06 A;  1QFC A;  2IAE C;  2WDD A;  3QFN A;  3AUZ A;  3TGH A;  4O24 A;  2IE3 C;  3AV0 A;  4UWQ A;  3H62 B;  1HO5 A;  4LAC C;  2O8A A;  3ICF A;  4YKE A;  2WDF A;  5HPE A;  5IOH A;  3CK2 A;  1V73 A;  3H66 A;  4H2F A;  5EQV A;  5F3W A;  1Z2W A;  1UF3 A;  4V0V A;  2Z72 A;  3H60 A;  1HPU A;  4ZX2 A;  5DNY A;  5GTU A;  4TUG A;  4O43 A;  2XMO A;  2QFP A;  4O5G A;  5JPE A;  2QFR A;  3HVQ A;  4V0X A;  4MP0 A;  3H63 A;  3RL3 A;  3RQZ A;  2NXF A;  1S3L A;  2O8G A;  4LU9 A;  3DSD A;  2DFJ A;  2AHD A;  2IE4 C;  4ORC A;  3T1I A;  4MOY A;  4OR9 A;  3QFK A;  3PSO A;  4NZV A;  4LTY A;  3RL4 A;  2NPP C;  3QFM A;  4H1S A;  4V0W A;  4KKZ A;  2KKN A;  3K7W C;  4FBQ A;  3ZTV A;  4JA7 A;  4B2O A;  4JA9 A;  3E7B A;  3JYF A;  1HP1 A;  1USH A;  3C5W C;  3DSC A;  2QJC A;  4ORA A;  3ZU0 A;  3H61 A;  1II7 A;  3KBP A;  4FBW A;  4UT2 A;  3EGH A;  4H1Y P;  1S3M A;  4HD0 A;  1FJM A;  3DW8 C;  4IYP C;  4IL1 A;  1OI8 A;  4UT3 A;  4F0Z A;  1JK7 A;  2A22 A;  1MF8 A;  1XM7 A;  1T70 A;  3H64 A;  3E7A A;  3PSN A;  2WDE A;  4KBP A;  2NYM C;  4FCX A;  2Z1A A;  1Z2X A;  4Q7F A;  4H2I A;  3IB8 A;  3THN A;  3H69 A;  1TCO A;  2R17 A;  3GVE A;  1NNW A;  4DT2 A;  1QHW A;  4XPN A;  3IVD A;  5JPF A;  4ORB A;  2GJU A;  3IB7 A;  3P71 C;  2BQ8 X;  4WWL A;  1SU1 A;  1T71 A;  4TUI A;  1WAR A;  1IT6 A;  4DHL A;  1S8E A;  1KBP A;  1XZW A;  2USH A;  5B8I A;  2BCD A;  5J28 A;  2HYO A;  4H2B A;  4ZVZ A;  1S70 A;  1S3N A;  1U32 A;  2WDC A;  3K7V C;  4I5N C;  3H68 A;  4I5L C;  2CV9 A;  1OIE A;  2HYP A;  3QG5 C;  4UT3 B;  2JOG A;  2ZBM A;  1AUI A;  4G9J A;  4DSY A;  4MOV A;  1M63 A;  2HY1 A;  2P6B A;  4FBK A;  5JJT A;  3QFO A;  3THO B;  3H67 A;  3RL5 A;  4H2G A;  3EGG A;  3LL8 A;  4J6O A;  2NYL C;  2Q8U A;  2YVT A;  5INB A;  3FGA C;  2BDX A;  1G5B A;  1OID A;  4M0V A;  1W24 A; 
#chains in the Genus database with same CATH topology
 3IVE A;  4O4K A;  5C1V A;  1UTE A;  1S95 A;  1WAO 1;  3V4Y A;  3N5U A;  3C9F A;  2Z06 A;  1QFC A;  2IAE C;  2WDD A;  3QFN A;  3AUZ A;  3TGH A;  4O24 A;  2IE3 C;  3AV0 A;  4UWQ A;  3H62 B;  1HO5 A;  4LAC C;  2O8A A;  3ICF A;  4YKE A;  2WDF A;  5HPE A;  5IOH A;  3CK2 A;  1V73 A;  3H66 A;  4H2F A;  5EQV A;  5F3W A;  1Z2W A;  1UF3 A;  4V0V A;  2Z72 A;  3H60 A;  1HPU A;  4ZX2 A;  5DNY A;  5GTU A;  4TUG A;  4O43 A;  3E0J A;  2XMO A;  2QFP A;  4O5G A;  5JPE A;  2QFR A;  3HVQ A;  4V0X A;  4MP0 A;  3H63 A;  3RL3 A;  3RQZ A;  2NXF A;  1S3L A;  2O8G A;  4LU9 A;  3DSD A;  2DXL A;  2DFJ A;  2AHD A;  2IE4 C;  4ORC A;  3T1I A;  4MOY A;  4OR9 A;  3QFK A;  3PSO A;  4NZV A;  4LTY A;  3RL4 A;  2NPP C;  3QFM A;  4H1S A;  4V0W A;  4KKZ A;  2KKN A;  3K7W C;  4FBQ A;  3ZTV A;  4JA7 A;  4B2O A;  4JA9 A;  3E7B A;  3JYF A;  1HP1 A;  1USH A;  3C5W C;  3DSC A;  2QJC A;  4ORA A;  3ZU0 A;  3H61 A;  1II7 A;  3KBP A;  4FBW A;  4UT2 A;  3EGH A;  4H1Y P;  1S3M A;  4HD0 A;  1FJM A;  3DW8 C;  4IYP C;  4IL1 A;  1OI8 A;  4UT3 A;  4F0Z A;  1JK7 A;  2A22 A;  1MF8 A;  2ZOA A;  1XM7 A;  1T70 A;  3H64 A;  3E7A A;  3PSN A;  2WDE A;  4KBP A;  2NYM C;  4FCX A;  2DXN A;  2Z1A A;  1Z2X A;  4Q7F A;  4H2I A;  3IB8 A;  3THN A;  3H69 A;  1TCO A;  2R17 A;  3GVE A;  1NNW A;  4DT2 A;  1QHW A;  4XPN A;  3IVD A;  5JPF A;  4ORB A;  2GJU A;  3IB7 A;  3P71 C;  2BQ8 X;  4WWL A;  2YEQ A;  1SU1 A;  1T71 A;  4TUI A;  1WAR A;  1IT6 A;  4DHL A;  1S8E A;  1KBP A;  1XZW A;  2USH A;  5B8I A;  2BCD A;  5J28 A;  2HYO A;  4H2B A;  4ZVZ A;  1S70 A;  2ZO9 B;  3D03 A;  1S3N A;  2WDC A;  1U32 A;  3K7V C;  4I5N C;  3H68 A;  4I5L C;  2CV9 A;  1OIE A;  2HYP A;  3FLO A;  3QG5 C;  2JOG A;  4UT3 B;  2ZBM A;  1AUI A;  4G9J A;  4DSY A;  4MOV A;  1M63 A;  2HY1 A;  2P6B A;  4FBK A;  5JJT A;  3QFO A;  3THO B;  3H67 A;  3RL5 A;  4H2G A;  3EGG A;  3LL8 A;  4J6O A;  2NYL C;  2Q8U A;  2YVT A;  5INB A;  3FGA C;  2BDX A;  1G5B A;  1OID A;  4M0V A;  1W24 A; 
#chains in the Genus database with same CATH homology
 3IVE A;  4O4K A;  5C1V A;  1UTE A;  1S95 A;  1WAO 1;  3V4Y A;  3N5U A;  3C9F A;  2Z06 A;  1QFC A;  2IAE C;  2WDD A;  3QFN A;  3AUZ A;  3TGH A;  4O24 A;  2IE3 C;  3AV0 A;  4UWQ A;  3H62 B;  1HO5 A;  4LAC C;  2O8A A;  3ICF A;  4YKE A;  2WDF A;  5HPE A;  5IOH A;  3CK2 A;  1V73 A;  3H66 A;  4H2F A;  5EQV A;  5F3W A;  1Z2W A;  1UF3 A;  4V0V A;  2Z72 A;  3H60 A;  1HPU A;  4ZX2 A;  5DNY A;  5GTU A;  4TUG A;  4O43 A;  3E0J A;  2XMO A;  2QFP A;  4O5G A;  5JPE A;  2QFR A;  3HVQ A;  4V0X A;  4MP0 A;  3H63 A;  3RL3 A;  3RQZ A;  2NXF A;  1S3L A;  2O8G A;  4LU9 A;  3DSD A;  2DXL A;  2DFJ A;  2AHD A;  2IE4 C;  4ORC A;  3T1I A;  4MOY A;  4OR9 A;  3QFK A;  3PSO A;  4NZV A;  4LTY A;  3RL4 A;  2NPP C;  3QFM A;  4H1S A;  4V0W A;  4KKZ A;  2KKN A;  3K7W C;  4FBQ A;  3ZTV A;  4JA7 A;  4B2O A;  4JA9 A;  3E7B A;  3JYF A;  1HP1 A;  1USH A;  3C5W C;  3DSC A;  2QJC A;  4ORA A;  3ZU0 A;  3H61 A;  1II7 A;  3KBP A;  4FBW A;  4UT2 A;  3EGH A;  4H1Y P;  1S3M A;  4HD0 A;  1FJM A;  3DW8 C;  4IYP C;  4IL1 A;  1OI8 A;  4UT3 A;  4F0Z A;  1JK7 A;  2A22 A;  1MF8 A;  2ZOA A;  1XM7 A;  1T70 A;  3H64 A;  3E7A A;  3PSN A;  2WDE A;  4KBP A;  2NYM C;  4FCX A;  2DXN A;  2Z1A A;  1Z2X A;  4Q7F A;  4H2I A;  3IB8 A;  3THN A;  3H69 A;  1TCO A;  2R17 A;  3GVE A;  1NNW A;  4DT2 A;  1QHW A;  4XPN A;  3IVD A;  5JPF A;  4ORB A;  2GJU A;  3IB7 A;  3P71 C;  2BQ8 X;  4WWL A;  2YEQ A;  1SU1 A;  1T71 A;  4TUI A;  1WAR A;  1IT6 A;  4DHL A;  1S8E A;  1KBP A;  1XZW A;  2USH A;  5B8I A;  2BCD A;  5J28 A;  2HYO A;  4H2B A;  4ZVZ A;  1S70 A;  2ZO9 B;  3D03 A;  1S3N A;  2WDC A;  1U32 A;  3K7V C;  4I5N C;  3H68 A;  4I5L C;  2CV9 A;  1OIE A;  2HYP A;  3FLO A;  3QG5 C;  2JOG A;  4UT3 B;  2ZBM A;  1AUI A;  4G9J A;  4DSY A;  4MOV A;  1M63 A;  2HY1 A;  2P6B A;  4FBK A;  5JJT A;  3QFO A;  3THO B;  3H67 A;  3RL5 A;  4H2G A;  3EGG A;  3LL8 A;  4J6O A;  2NYL C;  2Q8U A;  2YVT A;  5INB A;  3FGA C;  2BDX A;  1G5B A;  1OID A;  4M0V A;  1W24 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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