4H2BA

Human ecto-5'-nucleotidase (cd73): crystal form ii (open) in complex with baicalin
Total Genus 187
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
187
sequence length
524
structure length
524
Chain Sequence
PWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANISASGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHADEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTSCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/hydrolase inhibitor
molecule keywords 5'-nucleotidase
publication title Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling.
pubmed doi rcsb
source organism Homo sapiens
total genus 187
structure length 524
sequence length 524
ec nomenclature ec 3.1.3.5: 5'-nucleotidase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF02872 5_nucleotid_C 5'-nucleotidase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4h2bA01
3.90.780.10 Alpha Beta Alpha-Beta Complex 5'-nucleotidase; domain 2 5'-Nucleotidase, C-terminal domain 4h2bA02
4H1YP 1NNWA 4UWQA 1Z2WA 1HO5A 3C9FA 3QFNA 1XZWA 3IVEA 4LACC 3THOB 3ZU0A 1HPUA 5JPFA 4V0VA 1OI8A 1XM7A 2O8GA 1USHA 4TUGA 2AHDA 3P71C 5EQVA 2IE3C 2WDDA 2R17A 4LU9A 3H64A 2BQ8X 3IVDA 4ZX2A 4H2IA 2NYLC 2WDCA 5HPEA 3PSNA 1QFCA 3FGAC 3K7WC 4F0ZA 1UF3A 1TCOA 5DNYA 4FBKA 1FJMA 3H67A 1HP1A 4FCXA 3QFKA 4OR9A 1WARA 1S3MA 1T71A 4IYPC 4H2FA 4ORAA 4KBPA 4V0XA 5JPEA 4NZVA 2DFJA 3AUZA 5C1VA 4I5LC 3RL3A 5J28A 4KKZA 2BCDA 4H2GA 1V73A 3C5WC 3H63A 3E7AA 1AUIA 2O8AA 5JJTA 4I5NC 2XMOA 4J6OA 3EGHA 1Z2XA 1U32A 3H60A 4MP0A 3DSDA 3EGGA 2QFRA 1IT6A 5F3WA 2QJCA 2IE4C 1T70A 3IB7A 2HYPA 2CV9A 4O5GA 4ZVZA 4IL1A 1M63A 4TUIA 4O43A 4DT2A 4DSYA 1MF8A 2YVTA 4XPNA 3QFMA 2ZBMA 3THNA 2USHA 3H69A 4Q7FA 2A22A 3IB8A 3HVQA 4YKEA 2JOGA 2HY1A 2QFPA 3DW8C 1UTEA 3H61A 1KBPA 1S8EA 3QG5C 2NPPC 2KKNA 4DHLA 4MOYA 4MOVA 4UT3A 1JK7A 3RL4A 3GVEA 2IAEC 1OIDA 3PSOA 3AV0A 4ORBA 2Z1AA 1OIEA 3CK2A 5B8IA 4HD0A 4O4KA 3KBPA 2HYOA 4B2OA 3DSCA 4V0WA 3T1IA 3TGHA 3RL5A 2GJUA 5INBA 3K7VC 2WDFA 1WAO1 4FBQA 4WWLA 4G9JA 1S95A 1SU1A 2BDXA 5IOHA 4UT3B 2Q8UA 2NYMC 3H66A 1S3NA 3LL8A 4FBWA 3V4YA 1QHWA 3H68A 1S70A 4H1SA 1W24A 1G5BA 1II7A 4H2BA 3H62B 3E7BA 2WDEA 4M0VA 2Z06A 2P6BA 4LTYA 3N5UA 2Z72A 1S3LA 4JA9A 2NXFA 3ICFA 3QFOA 4O24A 5GTUA 3JYFA 3ZTVA 4ORCA 3RQZA 4JA7A 4UT2A
chains in the Genus database with same CATH superfamily
4H1YP 1NNWA 4UWQA 1Z2WA 1HO5A 3C9FA 3QFNA 1XZWA 3IVEA 4LACC 3THOB 3ZU0A 1HPUA 5JPFA 4V0VA 1OI8A 1XM7A 2O8GA 1USHA 4TUGA 2AHDA 3P71C 5EQVA 2IE3C 2WDDA 2R17A 4LU9A 3H64A 2BQ8X 3IVDA 4ZX2A 4H2IA 2NYLC 2WDCA 5HPEA 3PSNA 1QFCA 3FGAC 3K7WC 4F0ZA 2DXLA 1UF3A 1TCOA 5DNYA 4FBKA 1FJMA 3H67A 1HP1A 4FCXA 3QFKA 4OR9A 1WARA 1S3MA 1T71A 4IYPC 4H2FA 4ORAA 4KBPA 4V0XA 3D03A 5JPEA 4NZVA 2DFJA 3AUZA 5C1VA 4I5LC 3RL3A 5J28A 4KKZA 2BCDA 4H2GA 1V73A 3C5WC 3H63A 3E7AA 1AUIA 2O8AA 5JJTA 4I5NC 2XMOA 4J6OA 3EGHA 1Z2XA 1U32A 3H60A 4MP0A 3DSDA 3EGGA 2QFRA 1IT6A 5F3WA 2QJCA 2IE4C 1T70A 3IB7A 2HYPA 2CV9A 4O5GA 4ZVZA 4IL1A 1M63A 4TUIA 4O43A 4DT2A 4DSYA 2ZOAA 1MF8A 2YVTA 4XPNA 3QFMA 2ZBMA 3THNA 2USHA 3H69A 4Q7FA 2A22A 3IB8A 3HVQA 4YKEA 2JOGA 3FLOA 2HY1A 2QFPA 3DW8C 1UTEA 3H61A 1KBPA 1S8EA 3QG5C 2NPPC 2KKNA 4DHLA 4MOYA 4MOVA 4UT3A 1JK7A 3RL4A 3GVEA 2IAEC 1OIDA 3PSOA 3AV0A 4ORBA 2Z1AA 1OIEA 3CK2A 5B8IA 4HD0A 4O4KA 3KBPA 2HYOA 4B2OA 3DSCA 4V0WA 3T1IA 3TGHA 3RL5A 2GJUA 5INBA 3K7VC 2WDFA 1WAO1 4FBQA 4WWLA 4G9JA 1S95A 1SU1A 2BDXA 5IOHA 4UT3B 2Q8UA 2NYMC 3H66A 1S3NA 3LL8A 4FBWA 3V4YA 1QHWA 3H68A 3E0JA 2ZO9B 1S70A 4H1SA 1W24A 2YEQA 1G5BA 1II7A 4H2BA 3H62B 3E7BA 2WDEA 4M0VA 2Z06A 2P6BA 4LTYA 3N5UA 2Z72A 1S3LA 4JA9A 2NXFA 2DXNA 3ICFA 3QFOA 4O24A 3JYFA 5GTUA 3ZTVA 4ORCA 3RQZA 4JA7A 4UT2A
chains in the Genus database with same CATH topology
4H1YP 1NNWA 4UWQA 1Z2WA 1HO5A 3C9FA 3QFNA 1XZWA 3IVEA 4LACC 3THOB 3ZU0A 1HPUA 5JPFA 4V0VA 1OI8A 1XM7A 2O8GA 1USHA 4TUGA 2AHDA 3P71C 5EQVA 2IE3C 2WDDA 2R17A 4LU9A 3H64A 2BQ8X 3IVDA 4ZX2A 4H2IA 2NYLC 2WDCA 5HPEA 3PSNA 1QFCA 3FGAC 3K7WC 4F0ZA 2DXLA 1UF3A 1TCOA 5DNYA 4FBKA 1FJMA 3H67A 1HP1A 4FCXA 3QFKA 4OR9A 1WARA 1S3MA 1T71A 4IYPC 4H2FA 4ORAA 4KBPA 4V0XA 3D03A 5JPEA 4NZVA 2DFJA 3AUZA 5C1VA 4I5LC 3RL3A 5J28A 4KKZA 2BCDA 4H2GA 1V73A 3C5WC 3H63A 3E7AA 1AUIA 2O8AA 5JJTA 4I5NC 2XMOA 4J6OA 3EGHA 1Z2XA 1U32A 3H60A 4MP0A 3DSDA 3EGGA 2QFRA 1IT6A 5F3WA 2QJCA 2IE4C 1T70A 3IB7A 2HYPA 2CV9A 4O5GA 4ZVZA 4IL1A 1M63A 4TUIA 4O43A 4DT2A 4DSYA 2ZOAA 1MF8A 2YVTA 4XPNA 3QFMA 2ZBMA 3THNA 2USHA 3H69A 4Q7FA 2A22A 3IB8A 3HVQA 4YKEA 2JOGA 3FLOA 2HY1A 2QFPA 3DW8C 1UTEA 3H61A 1KBPA 1S8EA 3QG5C 2NPPC 2KKNA 4DHLA 4MOYA 4MOVA 4UT3A 1JK7A 3RL4A 3GVEA 2IAEC 1OIDA 3PSOA 3AV0A 4ORBA 2Z1AA 1OIEA 3CK2A 5B8IA 4HD0A 4O4KA 3KBPA 2HYOA 4B2OA 3DSCA 4V0WA 3T1IA 3TGHA 3RL5A 2GJUA 5INBA 3K7VC 2WDFA 1WAO1 4FBQA 4WWLA 4G9JA 1S95A 1SU1A 2BDXA 5IOHA 4UT3B 2Q8UA 2NYMC 3H66A 1S3NA 3LL8A 4FBWA 3V4YA 1QHWA 3H68A 3E0JA 2ZO9B 1S70A 4H1SA 1W24A 2YEQA 1G5BA 1II7A 4H2BA 3H62B 3E7BA 2WDEA 4M0VA 2Z06A 2P6BA 4LTYA 3N5UA 2Z72A 1S3LA 4JA9A 2NXFA 2DXNA 3ICFA 3QFOA 4O24A 3JYFA 5GTUA 3ZTVA 4ORCA 3RQZA 4JA7A 4UT2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4H1Y P;  1NNW A;  4UWQ A;  1Z2W A;  1HO5 A;  3C9F A;  3QFN A;  1XZW A;  3IVE A;  4LAC C;  3THO B;  3ZU0 A;  1HPU A;  5JPF A;  4V0V A;  1OI8 A;  1XM7 A;  2O8G A;  1USH A;  4TUG A;  2AHD A;  3P71 C;  5EQV A;  2IE3 C;  2WDD A;  2R17 A;  4LU9 A;  3H64 A;  2BQ8 X;  3IVD A;  4ZX2 A;  4H2I A;  2NYL C;  2WDC A;  5HPE A;  3PSN A;  1QFC A;  3FGA C;  3K7W C;  4F0Z A;  1UF3 A;  1TCO A;  5DNY A;  4FBK A;  1FJM A;  3H67 A;  1HP1 A;  4FCX A;  3QFK A;  4OR9 A;  1WAR A;  1S3M A;  1T71 A;  4IYP C;  4H2F A;  4ORA A;  4KBP A;  4V0X A;  5JPE A;  4NZV A;  2DFJ A;  3AUZ A;  5C1V A;  4I5L C;  3RL3 A;  5J28 A;  4KKZ A;  2BCD A;  4H2G A;  1V73 A;  3C5W C;  3H63 A;  3E7A A;  1AUI A;  2O8A A;  5JJT A;  4I5N C;  2XMO A;  4J6O A;  3EGH A;  1Z2X A;  1U32 A;  3H60 A;  4MP0 A;  3DSD A;  3EGG A;  2QFR A;  1IT6 A;  5F3W A;  2QJC A;  2IE4 C;  1T70 A;  3IB7 A;  2HYP A;  2CV9 A;  4O5G A;  4ZVZ A;  4IL1 A;  1M63 A;  4TUI A;  4O43 A;  4DT2 A;  4DSY A;  1MF8 A;  2YVT A;  4XPN A;  3QFM A;  2ZBM A;  3THN A;  2USH A;  3H69 A;  4Q7F A;  2A22 A;  3IB8 A;  3HVQ A;  4YKE A;  2JOG A;  2HY1 A;  2QFP A;  3DW8 C;  1UTE A;  3H61 A;  1KBP A;  1S8E A;  3QG5 C;  2NPP C;  2KKN A;  4DHL A;  4MOY A;  4MOV A;  4UT3 A;  1JK7 A;  3RL4 A;  3GVE A;  2IAE C;  1OID A;  3PSO A;  3AV0 A;  4ORB A;  2Z1A A;  1OIE A;  3CK2 A;  5B8I A;  4HD0 A;  4O4K A;  3KBP A;  2HYO A;  4B2O A;  3DSC A;  4V0W A;  3T1I A;  3TGH A;  3RL5 A;  2GJU A;  5INB A;  3K7V C;  2WDF A;  1WAO 1;  4FBQ A;  4WWL A;  4G9J A;  1S95 A;  1SU1 A;  2BDX A;  5IOH A;  4UT3 B;  2Q8U A;  2NYM C;  3H66 A;  1S3N A;  3LL8 A;  4FBW A;  3V4Y A;  1QHW A;  3H68 A;  1S70 A;  4H1S A;  1W24 A;  1G5B A;  1II7 A;  4H2B A;  3H62 B;  3E7B A;  2WDE A;  4M0V A;  2Z06 A;  2P6B A;  4LTY A;  3N5U A;  2Z72 A;  1S3L A;  4JA9 A;  2NXF A;  3ICF A;  3QFO A;  4O24 A;  5GTU A;  3JYF A;  3ZTV A;  4ORC A;  3RQZ A;  4JA7 A;  4UT2 A; 
#chains in the Genus database with same CATH topology
 4H1Y P;  1NNW A;  4UWQ A;  1Z2W A;  1HO5 A;  3C9F A;  3QFN A;  1XZW A;  3IVE A;  4LAC C;  3THO B;  3ZU0 A;  1HPU A;  5JPF A;  4V0V A;  1OI8 A;  1XM7 A;  2O8G A;  1USH A;  4TUG A;  2AHD A;  3P71 C;  5EQV A;  2IE3 C;  2WDD A;  2R17 A;  4LU9 A;  3H64 A;  2BQ8 X;  3IVD A;  4ZX2 A;  4H2I A;  2NYL C;  2WDC A;  5HPE A;  3PSN A;  1QFC A;  3FGA C;  3K7W C;  4F0Z A;  2DXL A;  1UF3 A;  1TCO A;  5DNY A;  4FBK A;  1FJM A;  3H67 A;  1HP1 A;  4FCX A;  3QFK A;  4OR9 A;  1WAR A;  1S3M A;  1T71 A;  4IYP C;  4H2F A;  4ORA A;  4KBP A;  4V0X A;  3D03 A;  5JPE A;  4NZV A;  2DFJ A;  3AUZ A;  5C1V A;  4I5L C;  3RL3 A;  5J28 A;  4KKZ A;  2BCD A;  4H2G A;  1V73 A;  3C5W C;  3H63 A;  3E7A A;  1AUI A;  2O8A A;  5JJT A;  4I5N C;  2XMO A;  4J6O A;  3EGH A;  1Z2X A;  1U32 A;  3H60 A;  4MP0 A;  3DSD A;  3EGG A;  2QFR A;  1IT6 A;  5F3W A;  2QJC A;  2IE4 C;  1T70 A;  3IB7 A;  2HYP A;  2CV9 A;  4O5G A;  4ZVZ A;  4IL1 A;  1M63 A;  4TUI A;  4O43 A;  4DT2 A;  4DSY A;  2ZOA A;  1MF8 A;  2YVT A;  4XPN A;  3QFM A;  2ZBM A;  3THN A;  2USH A;  3H69 A;  4Q7F A;  2A22 A;  3IB8 A;  3HVQ A;  4YKE A;  2JOG A;  3FLO A;  2HY1 A;  2QFP A;  3DW8 C;  1UTE A;  3H61 A;  1KBP A;  1S8E A;  3QG5 C;  2NPP C;  2KKN A;  4DHL A;  4MOY A;  4MOV A;  4UT3 A;  1JK7 A;  3RL4 A;  3GVE A;  2IAE C;  1OID A;  3PSO A;  3AV0 A;  4ORB A;  2Z1A A;  1OIE A;  3CK2 A;  5B8I A;  4HD0 A;  4O4K A;  3KBP A;  2HYO A;  4B2O A;  3DSC A;  4V0W A;  3T1I A;  3TGH A;  3RL5 A;  2GJU A;  5INB A;  3K7V C;  2WDF A;  1WAO 1;  4FBQ A;  4WWL A;  4G9J A;  1S95 A;  1SU1 A;  2BDX A;  5IOH A;  4UT3 B;  2Q8U A;  2NYM C;  3H66 A;  1S3N A;  3LL8 A;  4FBW A;  3V4Y A;  1QHW A;  3H68 A;  3E0J A;  2ZO9 B;  1S70 A;  4H1S A;  1W24 A;  2YEQ A;  1G5B A;  1II7 A;  4H2B A;  3H62 B;  3E7B A;  2WDE A;  4M0V A;  2Z06 A;  2P6B A;  4LTY A;  3N5U A;  2Z72 A;  1S3L A;  4JA9 A;  2NXF A;  2DXN A;  3ICF A;  3QFO A;  4O24 A;  3JYF A;  5GTU A;  3ZTV A;  4ORC A;  3RQZ A;  4JA7 A;  4UT2 A; 
#chains in the Genus database with same CATH homology
 4H1Y P;  1NNW A;  4UWQ A;  1Z2W A;  1HO5 A;  3C9F A;  3QFN A;  1XZW A;  3IVE A;  4LAC C;  3THO B;  3ZU0 A;  1HPU A;  5JPF A;  4V0V A;  1OI8 A;  1XM7 A;  2O8G A;  1USH A;  4TUG A;  2AHD A;  3P71 C;  5EQV A;  2IE3 C;  2WDD A;  2R17 A;  4LU9 A;  3H64 A;  2BQ8 X;  3IVD A;  4ZX2 A;  4H2I A;  2NYL C;  2WDC A;  5HPE A;  3PSN A;  1QFC A;  3FGA C;  3K7W C;  4F0Z A;  2DXL A;  1UF3 A;  1TCO A;  5DNY A;  4FBK A;  1FJM A;  3H67 A;  1HP1 A;  4FCX A;  3QFK A;  4OR9 A;  1WAR A;  1S3M A;  1T71 A;  4IYP C;  4H2F A;  4ORA A;  4KBP A;  4V0X A;  3D03 A;  5JPE A;  4NZV A;  2DFJ A;  3AUZ A;  5C1V A;  4I5L C;  3RL3 A;  5J28 A;  4KKZ A;  2BCD A;  4H2G A;  1V73 A;  3C5W C;  3H63 A;  3E7A A;  1AUI A;  2O8A A;  5JJT A;  4I5N C;  2XMO A;  4J6O A;  3EGH A;  1Z2X A;  1U32 A;  3H60 A;  4MP0 A;  3DSD A;  3EGG A;  2QFR A;  1IT6 A;  5F3W A;  2QJC A;  2IE4 C;  1T70 A;  3IB7 A;  2HYP A;  2CV9 A;  4O5G A;  4ZVZ A;  4IL1 A;  1M63 A;  4TUI A;  4O43 A;  4DT2 A;  4DSY A;  2ZOA A;  1MF8 A;  2YVT A;  4XPN A;  3QFM A;  2ZBM A;  3THN A;  2USH A;  3H69 A;  4Q7F A;  2A22 A;  3IB8 A;  3HVQ A;  4YKE A;  2JOG A;  3FLO A;  2HY1 A;  2QFP A;  3DW8 C;  1UTE A;  3H61 A;  1KBP A;  1S8E A;  3QG5 C;  2NPP C;  2KKN A;  4DHL A;  4MOY A;  4MOV A;  4UT3 A;  1JK7 A;  3RL4 A;  3GVE A;  2IAE C;  1OID A;  3PSO A;  3AV0 A;  4ORB A;  2Z1A A;  1OIE A;  3CK2 A;  5B8I A;  4HD0 A;  4O4K A;  3KBP A;  2HYO A;  4B2O A;  3DSC A;  4V0W A;  3T1I A;  3TGH A;  3RL5 A;  2GJU A;  5INB A;  3K7V C;  2WDF A;  1WAO 1;  4FBQ A;  4WWL A;  4G9J A;  1S95 A;  1SU1 A;  2BDX A;  5IOH A;  4UT3 B;  2Q8U A;  2NYM C;  3H66 A;  1S3N A;  3LL8 A;  4FBW A;  3V4Y A;  1QHW A;  3H68 A;  3E0J A;  2ZO9 B;  1S70 A;  4H1S A;  1W24 A;  2YEQ A;  1G5B A;  1II7 A;  4H2B A;  3H62 B;  3E7B A;  2WDE A;  4M0V A;  2Z06 A;  2P6B A;  4LTY A;  3N5U A;  2Z72 A;  1S3L A;  4JA9 A;  2NXF A;  2DXN A;  3ICF A;  3QFO A;  4O24 A;  3JYF A;  5GTU A;  3ZTV A;  4ORC A;  3RQZ A;  4JA7 A;  4UT2 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...