4H2BA

Human ecto-5'-nucleotidase (cd73): crystal form ii (open) in complex with baicalin
Total Genus 187
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
187
sequence length
524
structure length
524
Chain Sequence
PWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANISASGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHADEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTSCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords 5'-nucleotidase
publication title Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/hydrolase inhibitor
total genus 187
structure length 524
sequence length 524
ec nomenclature ec 3.1.3.5: 5'-nucleotidase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF02872 5_nucleotid_C 5'-nucleotidase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4h2bA01
3.90.780.10 Alpha Beta Alpha-Beta Complex 5'-nucleotidase; domain 2 5'-Nucleotidase, C-terminal domain 4h2bA02
2Q8UA 3HVQA 1M63A 1UTEA 2WDCA 4I5LC 2A22A 2P6BA 2ZBMA 1U32A 1WAO1 3IVEA 4V0VA 5HPEA 1MF8A 3P71C 1AUIA 4G9JA 3THOB 5J28A 1Z2WA 2QFRA 2QJCA 4FCXA 1JK7A 4JA9A 1KBPA 3QFKA 4B2OA 3K7WC 4LTYA 1V73A 3PSOA 3KBPA 4FBWA 2O8AA 4KKZA 3ZU0A 1S3LA 3IB8A 1HO5A 3H67A 3H66A 2HYPA 4NZVA 3K7VC 4Q7FA 1USHA 1QFCA 2GJUA 2NPPC 1UF3A 2HYOA 5JJTA 3DSDA 2IE3C 4O5GA 4UT3A 3EGHA 3IB7A 3CK2A 3H69A 3V4YA 4M0VA 3AV0A 5EQVA 4IYPC 1S8EA 2IE4C 4J6OA 1OIDA 3ZTVA 1TCOA 2BCDA 4FBKA 4O43A 4ZX2A 3H63A 1S70A 4ORCA 1FJMA 2DFJA 4ORBA 4H2IA 4LACC 3AUZA 1OIEA 5GTUA 3RL4A 1IT6A 2BDXA 4H1YP 3RQZA 2CV9A 2R17A 1S3NA 3QFOA 2JOGA 3N5UA 3LL8A 3QFMA 4UWQA 4O24A 1QHWA 3DW8C 4XPNA 4JA7A 3QFNA 5F3WA 1II7A 5IOHA 4MOVA 4ZVZA 2NYLC 4LU9A 4FBQA 3E7BA 4IL1A 4WWLA 5JPFA 2YVTA 3ICFA 4DHLA 5B8IA 1T71A 2Z06A 5C1VA 2XMOA 4MP0A 1XZWA 4UT2A 5INBA 4TUIA 2Z1AA 3IVDA 4DSYA 2QFPA 1Z2XA 2NYMC 3PSNA 5JPEA 5DNYA 3E7AA 4UT3B 2WDFA 4H2BA 4V0WA 3TGHA 3THNA 2HY1A 4ORAA 4YKEA 4V0XA 1SU1A 3H68A 4KBPA 4F0ZA 1OI8A 1HP1A 1T70A 2NXFA 2WDEA 3FGAC 3H60A 1W24A 2KKNA 1XM7A 1WARA 2IAEC 2USHA 3C5WC 3C9FA 3QG5C 2AHDA 4HD0A 3H64A 3T1IA 2BQ8X 3RL5A 2WDDA 3H62B 4H2GA 3RL3A 3DSCA 4OR9A 2O8GA 3GVEA 4H2FA 4TUGA 1S95A 4O4KA 4DT2A 2Z72A 3H61A 4H1SA 1G5BA 1S3MA 3EGGA 3JYFA 1HPUA 4I5NC 4MOYA 1NNWA
chains in the Genus database with same CATH superfamily
2Q8UA 3HVQA 1M63A 1UTEA 2WDCA 4I5LC 2A22A 2P6BA 2ZBMA 1U32A 1WAO1 3IVEA 4V0VA 5HPEA 1MF8A 3P71C 1AUIA 4G9JA 3THOB 5J28A 1Z2WA 2QFRA 2QJCA 4FCXA 1JK7A 4JA9A 1KBPA 3QFKA 4B2OA 3K7WC 4LTYA 1V73A 3PSOA 3KBPA 4FBWA 2O8AA 4KKZA 3ZU0A 1S3LA 3IB8A 1HO5A 3H67A 3H66A 2ZO9B 2HYPA 4NZVA 3K7VC 4Q7FA 1USHA 1QFCA 2GJUA 2NPPC 1UF3A 2HYOA 5JJTA 3DSDA 2IE3C 4O5GA 4UT3A 3EGHA 3IB7A 3CK2A 3H69A 3V4YA 4M0VA 3AV0A 5EQVA 4IYPC 1S8EA 2IE4C 4J6OA 1OIDA 3ZTVA 1TCOA 2BCDA 2ZOAA 4FBKA 4O43A 3H63A 4ZX2A 1S70A 4ORCA 2DXNA 1FJMA 2DFJA 4ORBA 4H2IA 4LACC 3AUZA 1OIEA 5GTUA 3RL4A 1IT6A 2BDXA 4H1YP 3RQZA 2CV9A 2R17A 1S3NA 3QFOA 2JOGA 3N5UA 3LL8A 3QFMA 4UWQA 4O24A 1QHWA 3DW8C 4XPNA 4JA7A 3QFNA 5F3WA 1II7A 5IOHA 4MOVA 4ZVZA 2NYLC 4LU9A 4FBQA 3E7BA 4IL1A 4WWLA 5JPFA 2YVTA 3ICFA 4DHLA 5B8IA 1T71A 2Z06A 5C1VA 2XMOA 4MP0A 1XZWA 4UT2A 5INBA 4TUIA 2Z1AA 3IVDA 4DSYA 2QFPA 1Z2XA 2NYMC 3PSNA 5JPEA 5DNYA 3E7AA 4UT3B 2WDFA 4H2BA 4V0WA 3TGHA 3THNA 2DXLA 2HY1A 3E0JA 4ORAA 1SU1A 4V0XA 3H68A 4YKEA 4KBPA 4F0ZA 1OI8A 1HP1A 1T70A 2NXFA 2WDEA 3FGAC 3H60A 1W24A 2KKNA 3D03A 1XM7A 1WARA 2IAEC 2USHA 3C5WC 3C9FA 3FLOA 3QG5C 2AHDA 4HD0A 3H64A 3T1IA 2BQ8X 3RL5A 2WDDA 3H62B 4H2GA 3RL3A 3DSCA 4OR9A 2YEQA 2O8GA 3GVEA 4H2FA 4TUGA 1S95A 4O4KA 4DT2A 2Z72A 3H61A 4H1SA 1G5BA 1S3MA 3EGGA 3JYFA 1HPUA 4I5NC 4MOYA 1NNWA
chains in the Genus database with same CATH topology
2Q8UA 3HVQA 1M63A 1UTEA 2WDCA 4I5LC 2A22A 2P6BA 2ZBMA 1U32A 1WAO1 3IVEA 4V0VA 5HPEA 1MF8A 3P71C 1AUIA 4G9JA 3THOB 5J28A 1Z2WA 2QFRA 2QJCA 4FCXA 1JK7A 4JA9A 1KBPA 3QFKA 4B2OA 3K7WC 4LTYA 1V73A 3PSOA 3KBPA 4FBWA 2O8AA 4KKZA 3ZU0A 1S3LA 3IB8A 1HO5A 3H67A 3H66A 2ZO9B 2HYPA 4NZVA 3K7VC 4Q7FA 1USHA 1QFCA 2GJUA 2NPPC 1UF3A 2HYOA 5JJTA 3DSDA 2IE3C 4O5GA 4UT3A 3EGHA 3IB7A 3CK2A 3H69A 3V4YA 4M0VA 3AV0A 5EQVA 4IYPC 1S8EA 2IE4C 4J6OA 1OIDA 3ZTVA 1TCOA 2BCDA 2ZOAA 4FBKA 4O43A 3H63A 4ZX2A 1S70A 4ORCA 2DXNA 1FJMA 2DFJA 4ORBA 4H2IA 4LACC 3AUZA 1OIEA 5GTUA 3RL4A 1IT6A 2BDXA 4H1YP 3RQZA 2CV9A 2R17A 1S3NA 3QFOA 2JOGA 3N5UA 3LL8A 3QFMA 4UWQA 4O24A 1QHWA 3DW8C 4XPNA 4JA7A 3QFNA 5F3WA 1II7A 5IOHA 4MOVA 4ZVZA 2NYLC 4LU9A 4FBQA 3E7BA 4IL1A 4WWLA 5JPFA 2YVTA 3ICFA 4DHLA 5B8IA 1T71A 2Z06A 5C1VA 2XMOA 4MP0A 1XZWA 4UT2A 5INBA 4TUIA 2Z1AA 3IVDA 4DSYA 2QFPA 1Z2XA 2NYMC 3PSNA 5JPEA 5DNYA 3E7AA 4UT3B 2WDFA 4H2BA 4V0WA 3TGHA 3THNA 2DXLA 2HY1A 3E0JA 4ORAA 1SU1A 4V0XA 3H68A 4YKEA 4KBPA 4F0ZA 1OI8A 1HP1A 1T70A 2NXFA 2WDEA 3FGAC 3H60A 1W24A 2KKNA 3D03A 1XM7A 1WARA 2IAEC 2USHA 3C5WC 3C9FA 3FLOA 3QG5C 2AHDA 4HD0A 3H64A 3T1IA 2BQ8X 3RL5A 2WDDA 3H62B 4H2GA 3RL3A 3DSCA 4OR9A 2YEQA 2O8GA 3GVEA 4H2FA 4TUGA 1S95A 4O4KA 4DT2A 2Z72A 3H61A 4H1SA 1G5BA 1S3MA 3EGGA 3JYFA 1HPUA 4I5NC 4MOYA 1NNWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Q8U A;  3HVQ A;  1M63 A;  1UTE A;  2WDC A;  4I5L C;  2A22 A;  2P6B A;  2ZBM A;  1U32 A;  1WAO 1;  3IVE A;  4V0V A;  5HPE A;  1MF8 A;  3P71 C;  1AUI A;  4G9J A;  3THO B;  5J28 A;  1Z2W A;  2QFR A;  2QJC A;  4FCX A;  1JK7 A;  4JA9 A;  1KBP A;  3QFK A;  4B2O A;  3K7W C;  4LTY A;  1V73 A;  3PSO A;  3KBP A;  4FBW A;  2O8A A;  4KKZ A;  3ZU0 A;  1S3L A;  3IB8 A;  1HO5 A;  3H67 A;  3H66 A;  2HYP A;  4NZV A;  3K7V C;  4Q7F A;  1USH A;  1QFC A;  2GJU A;  2NPP C;  1UF3 A;  2HYO A;  5JJT A;  3DSD A;  2IE3 C;  4O5G A;  4UT3 A;  3EGH A;  3IB7 A;  3CK2 A;  3H69 A;  3V4Y A;  4M0V A;  3AV0 A;  5EQV A;  4IYP C;  1S8E A;  2IE4 C;  4J6O A;  1OID A;  3ZTV A;  1TCO A;  2BCD A;  4FBK A;  4O43 A;  4ZX2 A;  3H63 A;  1S70 A;  4ORC A;  1FJM A;  2DFJ A;  4ORB A;  4H2I A;  4LAC C;  3AUZ A;  1OIE A;  5GTU A;  3RL4 A;  1IT6 A;  2BDX A;  4H1Y P;  3RQZ A;  2CV9 A;  2R17 A;  1S3N A;  3QFO A;  2JOG A;  3N5U A;  3LL8 A;  3QFM A;  4UWQ A;  4O24 A;  1QHW A;  3DW8 C;  4XPN A;  4JA7 A;  3QFN A;  5F3W A;  1II7 A;  5IOH A;  4MOV A;  4ZVZ A;  2NYL C;  4LU9 A;  4FBQ A;  3E7B A;  4IL1 A;  4WWL A;  5JPF A;  2YVT A;  3ICF A;  4DHL A;  5B8I A;  1T71 A;  2Z06 A;  5C1V A;  2XMO A;  4MP0 A;  1XZW A;  4UT2 A;  5INB A;  4TUI A;  2Z1A A;  3IVD A;  4DSY A;  2QFP A;  1Z2X A;  2NYM C;  3PSN A;  5JPE A;  5DNY A;  3E7A A;  4UT3 B;  2WDF A;  4H2B A;  4V0W A;  3TGH A;  3THN A;  2HY1 A;  4ORA A;  4YKE A;  4V0X A;  1SU1 A;  3H68 A;  4KBP A;  4F0Z A;  1OI8 A;  1HP1 A;  1T70 A;  2NXF A;  2WDE A;  3FGA C;  3H60 A;  1W24 A;  2KKN A;  1XM7 A;  1WAR A;  2IAE C;  2USH A;  3C5W C;  3C9F A;  3QG5 C;  2AHD A;  4HD0 A;  3H64 A;  3T1I A;  2BQ8 X;  3RL5 A;  2WDD A;  3H62 B;  4H2G A;  3RL3 A;  3DSC A;  4OR9 A;  2O8G A;  3GVE A;  4H2F A;  4TUG A;  1S95 A;  4O4K A;  4DT2 A;  2Z72 A;  3H61 A;  4H1S A;  1G5B A;  1S3M A;  3EGG A;  3JYF A;  1HPU A;  4I5N C;  4MOY A;  1NNW A; 
#chains in the Genus database with same CATH topology
 2Q8U A;  3HVQ A;  1M63 A;  1UTE A;  2WDC A;  4I5L C;  2A22 A;  2P6B A;  2ZBM A;  1U32 A;  1WAO 1;  3IVE A;  4V0V A;  5HPE A;  1MF8 A;  3P71 C;  1AUI A;  4G9J A;  3THO B;  5J28 A;  1Z2W A;  2QFR A;  2QJC A;  4FCX A;  1JK7 A;  4JA9 A;  1KBP A;  3QFK A;  4B2O A;  3K7W C;  4LTY A;  1V73 A;  3PSO A;  3KBP A;  4FBW A;  2O8A A;  4KKZ A;  3ZU0 A;  1S3L A;  3IB8 A;  1HO5 A;  3H67 A;  3H66 A;  2ZO9 B;  2HYP A;  4NZV A;  3K7V C;  4Q7F A;  1USH A;  1QFC A;  2GJU A;  2NPP C;  1UF3 A;  2HYO A;  5JJT A;  3DSD A;  2IE3 C;  4O5G A;  4UT3 A;  3EGH A;  3IB7 A;  3CK2 A;  3H69 A;  3V4Y A;  4M0V A;  3AV0 A;  5EQV A;  4IYP C;  1S8E A;  2IE4 C;  4J6O A;  1OID A;  3ZTV A;  1TCO A;  2BCD A;  2ZOA A;  4FBK A;  4O43 A;  3H63 A;  4ZX2 A;  1S70 A;  4ORC A;  2DXN A;  1FJM A;  2DFJ A;  4ORB A;  4H2I A;  4LAC C;  3AUZ A;  1OIE A;  5GTU A;  3RL4 A;  1IT6 A;  2BDX A;  4H1Y P;  3RQZ A;  2CV9 A;  2R17 A;  1S3N A;  3QFO A;  2JOG A;  3N5U A;  3LL8 A;  3QFM A;  4UWQ A;  4O24 A;  1QHW A;  3DW8 C;  4XPN A;  4JA7 A;  3QFN A;  5F3W A;  1II7 A;  5IOH A;  4MOV A;  4ZVZ A;  2NYL C;  4LU9 A;  4FBQ A;  3E7B A;  4IL1 A;  4WWL A;  5JPF A;  2YVT A;  3ICF A;  4DHL A;  5B8I A;  1T71 A;  2Z06 A;  5C1V A;  2XMO A;  4MP0 A;  1XZW A;  4UT2 A;  5INB A;  4TUI A;  2Z1A A;  3IVD A;  4DSY A;  2QFP A;  1Z2X A;  2NYM C;  3PSN A;  5JPE A;  5DNY A;  3E7A A;  4UT3 B;  2WDF A;  4H2B A;  4V0W A;  3TGH A;  3THN A;  2DXL A;  2HY1 A;  3E0J A;  4ORA A;  1SU1 A;  4V0X A;  3H68 A;  4YKE A;  4KBP A;  4F0Z A;  1OI8 A;  1HP1 A;  1T70 A;  2NXF A;  2WDE A;  3FGA C;  3H60 A;  1W24 A;  2KKN A;  3D03 A;  1XM7 A;  1WAR A;  2IAE C;  2USH A;  3C5W C;  3C9F A;  3FLO A;  3QG5 C;  2AHD A;  4HD0 A;  3H64 A;  3T1I A;  2BQ8 X;  3RL5 A;  2WDD A;  3H62 B;  4H2G A;  3RL3 A;  3DSC A;  4OR9 A;  2YEQ A;  2O8G A;  3GVE A;  4H2F A;  4TUG A;  1S95 A;  4O4K A;  4DT2 A;  2Z72 A;  3H61 A;  4H1S A;  1G5B A;  1S3M A;  3EGG A;  3JYF A;  1HPU A;  4I5N C;  4MOY A;  1NNW A; 
#chains in the Genus database with same CATH homology
 2Q8U A;  3HVQ A;  1M63 A;  1UTE A;  2WDC A;  4I5L C;  2A22 A;  2P6B A;  2ZBM A;  1U32 A;  1WAO 1;  3IVE A;  4V0V A;  5HPE A;  1MF8 A;  3P71 C;  1AUI A;  4G9J A;  3THO B;  5J28 A;  1Z2W A;  2QFR A;  2QJC A;  4FCX A;  1JK7 A;  4JA9 A;  1KBP A;  3QFK A;  4B2O A;  3K7W C;  4LTY A;  1V73 A;  3PSO A;  3KBP A;  4FBW A;  2O8A A;  4KKZ A;  3ZU0 A;  1S3L A;  3IB8 A;  1HO5 A;  3H67 A;  3H66 A;  2ZO9 B;  2HYP A;  4NZV A;  3K7V C;  4Q7F A;  1USH A;  1QFC A;  2GJU A;  2NPP C;  1UF3 A;  2HYO A;  5JJT A;  3DSD A;  2IE3 C;  4O5G A;  4UT3 A;  3EGH A;  3IB7 A;  3CK2 A;  3H69 A;  3V4Y A;  4M0V A;  3AV0 A;  5EQV A;  4IYP C;  1S8E A;  2IE4 C;  4J6O A;  1OID A;  3ZTV A;  1TCO A;  2BCD A;  2ZOA A;  4FBK A;  4O43 A;  3H63 A;  4ZX2 A;  1S70 A;  4ORC A;  2DXN A;  1FJM A;  2DFJ A;  4ORB A;  4H2I A;  4LAC C;  3AUZ A;  1OIE A;  5GTU A;  3RL4 A;  1IT6 A;  2BDX A;  4H1Y P;  3RQZ A;  2CV9 A;  2R17 A;  1S3N A;  3QFO A;  2JOG A;  3N5U A;  3LL8 A;  3QFM A;  4UWQ A;  4O24 A;  1QHW A;  3DW8 C;  4XPN A;  4JA7 A;  3QFN A;  5F3W A;  1II7 A;  5IOH A;  4MOV A;  4ZVZ A;  2NYL C;  4LU9 A;  4FBQ A;  3E7B A;  4IL1 A;  4WWL A;  5JPF A;  2YVT A;  3ICF A;  4DHL A;  5B8I A;  1T71 A;  2Z06 A;  5C1V A;  2XMO A;  4MP0 A;  1XZW A;  4UT2 A;  5INB A;  4TUI A;  2Z1A A;  3IVD A;  4DSY A;  2QFP A;  1Z2X A;  2NYM C;  3PSN A;  5JPE A;  5DNY A;  3E7A A;  4UT3 B;  2WDF A;  4H2B A;  4V0W A;  3TGH A;  3THN A;  2DXL A;  2HY1 A;  3E0J A;  4ORA A;  1SU1 A;  4V0X A;  3H68 A;  4YKE A;  4KBP A;  4F0Z A;  1OI8 A;  1HP1 A;  1T70 A;  2NXF A;  2WDE A;  3FGA C;  3H60 A;  1W24 A;  2KKN A;  3D03 A;  1XM7 A;  1WAR A;  2IAE C;  2USH A;  3C5W C;  3C9F A;  3FLO A;  3QG5 C;  2AHD A;  4HD0 A;  3H64 A;  3T1I A;  2BQ8 X;  3RL5 A;  2WDD A;  3H62 B;  4H2G A;  3RL3 A;  3DSC A;  4OR9 A;  2YEQ A;  2O8G A;  3GVE A;  4H2F A;  4TUG A;  1S95 A;  4O4K A;  4DT2 A;  2Z72 A;  3H61 A;  4H1S A;  1G5B A;  1S3M A;  3EGG A;  3JYF A;  1HPU A;  4I5N C;  4MOY A;  1NNW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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