2BQ8X

Crystal structure of human purple acid phosphatase with an inhibitory conformation of the repression loop
Total Genus 103
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
103
sequence length
304
structure length
304
Chain Sequence
ATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQETFEDVFSDRSLRKVPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSDDFLSQQPERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLVKQLRPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSKRHQRKVPNGYLRFHYGTEDSLGGFAYVEISSKEMTVTYIEASGKSLFKTRLPRRARP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5
publication title Crystal Structures of Recombinant Human Purple Acid Phosphatase with and without an Inhibitory Conformation of the Repression Loop.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 103
structure length 304
sequence length 304
ec nomenclature ec 3.1.3.2: Acid phosphatase.
pdb deposition date 2005-04-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2bq8X00
2O8AA 2IE3C 1OIDA 4H1SA 2CV9A 5HPEA 1FJMA 3H64A 3K7VC 4MOVA 3FGAC 4H2IA 4KBPA 1S3NA 4V0WA 1HO5A 1S95A 4H2FA 2Z72A 4H2BA 2NPPC 3H69A 2USHA 3QG5C 4I5LC 5B8IA 2WDCA 3HVQA 3LL8A 2JOGA 2HY1A 3DW8C 4J6OA 1XM7A 4FBKA 3KBPA 2AHDA 4O5GA 1UTEA 4DSYA 3RL4A 2BDXA 3C9FA 5DNYA 5JPFA 1UF3A 4FBQA 1QFCA 4FBWA 2QFRA 1TCOA 3E7AA 3H61A 3C5WC 4FCXA 1HPUA 1S3MA 3AUZA 2NYLC 2O8GA 3QFNA 2QFPA 1MF8A 2GJUA 1IT6A 4UWQA 2P6BA 2NXFA 1G5BA 3H62B 2YVTA 4O4KA 3DSCA 4Q7FA 4DHLA 4NZVA 3IB8A 3ZTVA 3EGHA 1T70A 5EQVA 3N5UA 1WARA 4MOYA 3PSOA 3QFMA 1NNWA 2NYMC 1Z2WA 1JK7A 3T1IA 4KKZA 2BQ8X 1XZWA 2HYOA 2Q8UA 3H68A 3H63A 1M63A 5IOHA 5GTUA 3IVEA 3P71C 5C1VA 3V4YA 2KKNA 1S8EA 1OI8A 2IAEC 3JYFA 3THOB 2Z06A 4H2GA 5INBA 4UT2A 2WDEA 4TUIA 1OIEA 1SU1A 3RL5A 4UT3A 2WDFA 1WAO1 4V0XA 4IL1A 1S70A 3H67A 4ORAA 4I5NC 2Z1AA 4UT3B 1U32A 2R17A 3GVEA 4M0VA 4LTYA 1Z2XA 1II7A 1AUIA 3TGHA 3QFKA 3EGGA 4YKEA 3IVDA 3H60A 4JA7A 3ZU0A 5JPEA 4LACC 1W24A 1QHWA 3K7WC 4ZX2A 2ZBMA 2HYPA 4WWLA 5JJTA 3AV0A 4G9JA 4ORBA 4V0VA 2XMOA 5J28A 1S3LA 1T71A 4MP0A 4B2OA 3IB7A 3ICFA 4TUGA 3H66A 2BCDA 4HD0A 4ORCA 4IYPC 2DFJA 1KBPA 2A22A 3PSNA 4O24A 4ZVZA 4OR9A 3RL3A 3RQZA 3CK2A 3THNA 4H1YP 4DT2A 1USHA 4F0ZA 2IE4C 3QFOA 3E7BA 1HP1A 1V73A 2QJCA 2WDDA 4JA9A 4XPNA 3DSDA 5F3WA 4O43A 4LU9A
chains in the Genus database with same CATH superfamily
2O8AA 2IE3C 1OIDA 4H1SA 2CV9A 5HPEA 1FJMA 3H64A 3K7VC 4MOVA 3FGAC 4H2IA 4KBPA 1S3NA 4V0WA 1HO5A 1S95A 3E0JA 4H2FA 2Z72A 4H2BA 2NPPC 3H69A 2USHA 3QG5C 4I5LC 5B8IA 2WDCA 3HVQA 3LL8A 2JOGA 2HY1A 3DW8C 4J6OA 1XM7A 4FBKA 3KBPA 2AHDA 4O5GA 1UTEA 4DSYA 3RL4A 2BDXA 3C9FA 5DNYA 5JPFA 1UF3A 4FBQA 1QFCA 4FBWA 2QFRA 1TCOA 3E7AA 3H61A 3C5WC 4FCXA 1HPUA 1S3MA 3AUZA 2NYLC 2O8GA 3QFNA 2QFPA 1MF8A 2GJUA 1IT6A 4UWQA 2P6BA 2NXFA 4LU9A 1G5BA 3H62B 2YVTA 4O4KA 3DSCA 4Q7FA 4DHLA 4NZVA 3IB8A 3ZTVA 3EGHA 1T70A 5EQVA 3N5UA 2DXNA 1WARA 4MOYA 3PSOA 3QFMA 1NNWA 2NYMC 1Z2WA 1JK7A 3T1IA 4KKZA 2BQ8X 1XZWA 2HYOA 2Q8UA 3H68A 3H63A 1M63A 5IOHA 5GTUA 3IVEA 3P71C 3D03A 5C1VA 3V4YA 2KKNA 1S8EA 1OI8A 2IAEC 3JYFA 3THOB 2Z06A 4H2GA 5INBA 4UT2A 2WDEA 4TUIA 1OIEA 1SU1A 2ZO9B 3RL5A 2WDFA 4UT3A 1WAO1 4V0XA 4IL1A 1S70A 3H67A 4ORAA 4I5NC 2Z1AA 4UT3B 1U32A 2R17A 3GVEA 4M0VA 4LTYA 1Z2XA 1II7A 1AUIA 3FLOA 3TGHA 3QFKA 3EGGA 4YKEA 3IVDA 3H60A 4JA7A 3ZU0A 5JPEA 4LACC 1W24A 1QHWA 3K7WC 4ZX2A 2ZBMA 2HYPA 2ZOAA 4WWLA 5JJTA 3AV0A 4G9JA 4ORBA 4V0VA 2XMOA 5J28A 1S3LA 1T71A 4MP0A 4B2OA 2DXLA 3IB7A 3ICFA 4TUGA 3H66A 2BCDA 4HD0A 4ORCA 4IYPC 2DFJA 1KBPA 2A22A 3PSNA 4O24A 4ZVZA 4OR9A 3RL3A 3RQZA 3CK2A 3THNA 4H1YP 4DT2A 1USHA 4F0ZA 2IE4C 3QFOA 3E7BA 1HP1A 1V73A 2QJCA 2WDDA 4JA9A 4XPNA 3DSDA 5F3WA 4O43A 2YEQA
chains in the Genus database with same CATH topology
2O8AA 2IE3C 1OIDA 4H1SA 2CV9A 5HPEA 1FJMA 3H64A 3K7VC 4MOVA 3FGAC 4H2IA 4KBPA 1S3NA 4V0WA 1HO5A 1S95A 3E0JA 4H2FA 2Z72A 4H2BA 2NPPC 3H69A 2USHA 3QG5C 4I5LC 5B8IA 2WDCA 3HVQA 3LL8A 2JOGA 2HY1A 3DW8C 4J6OA 1XM7A 4FBKA 3KBPA 2AHDA 4O5GA 1UTEA 4DSYA 3RL4A 2BDXA 3C9FA 5DNYA 5JPFA 1UF3A 4FBQA 1QFCA 4FBWA 2QFRA 1TCOA 3E7AA 3H61A 3C5WC 4FCXA 1HPUA 1S3MA 3AUZA 2NYLC 2O8GA 3QFNA 2QFPA 1MF8A 2GJUA 1IT6A 4UWQA 2P6BA 2NXFA 4LU9A 1G5BA 3H62B 2YVTA 4O4KA 3DSCA 4Q7FA 4DHLA 4NZVA 3IB8A 3ZTVA 3EGHA 1T70A 5EQVA 3N5UA 2DXNA 1WARA 4MOYA 3PSOA 3QFMA 1NNWA 2NYMC 1Z2WA 1JK7A 3T1IA 4KKZA 2BQ8X 1XZWA 2HYOA 2Q8UA 3H68A 3H63A 1M63A 5IOHA 5GTUA 3IVEA 3P71C 3D03A 5C1VA 3V4YA 2KKNA 1S8EA 1OI8A 2IAEC 3JYFA 3THOB 2Z06A 4H2GA 5INBA 4UT2A 2WDEA 4TUIA 1OIEA 1SU1A 2ZO9B 3RL5A 2WDFA 4UT3A 1WAO1 4V0XA 4IL1A 1S70A 3H67A 4ORAA 4I5NC 2Z1AA 4UT3B 1U32A 2R17A 3GVEA 4M0VA 4LTYA 1Z2XA 1II7A 1AUIA 3FLOA 3TGHA 3QFKA 3EGGA 4YKEA 3IVDA 3H60A 4JA7A 3ZU0A 5JPEA 4LACC 1W24A 1QHWA 3K7WC 4ZX2A 2ZBMA 2HYPA 2ZOAA 4WWLA 5JJTA 3AV0A 4G9JA 4ORBA 4V0VA 2XMOA 5J28A 1S3LA 1T71A 4MP0A 4B2OA 2DXLA 3IB7A 3ICFA 4TUGA 3H66A 2BCDA 4HD0A 4ORCA 4IYPC 2DFJA 1KBPA 2A22A 3PSNA 4O24A 4ZVZA 4OR9A 3RL3A 3RQZA 3CK2A 3THNA 4H1YP 4DT2A 1USHA 4F0ZA 2IE4C 3QFOA 3E7BA 1HP1A 1V73A 2QJCA 2WDDA 4JA9A 4XPNA 3DSDA 5F3WA 4O43A 2YEQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O8A A;  2IE3 C;  1OID A;  4H1S A;  2CV9 A;  5HPE A;  1FJM A;  3H64 A;  3K7V C;  4MOV A;  3FGA C;  4H2I A;  4KBP A;  1S3N A;  4V0W A;  1HO5 A;  1S95 A;  4H2F A;  2Z72 A;  4H2B A;  2NPP C;  3H69 A;  2USH A;  3QG5 C;  4I5L C;  5B8I A;  2WDC A;  3HVQ A;  3LL8 A;  2JOG A;  2HY1 A;  3DW8 C;  4J6O A;  1XM7 A;  4FBK A;  3KBP A;  2AHD A;  4O5G A;  1UTE A;  4DSY A;  3RL4 A;  2BDX A;  3C9F A;  5DNY A;  5JPF A;  1UF3 A;  4FBQ A;  1QFC A;  4FBW A;  2QFR A;  1TCO A;  3E7A A;  3H61 A;  3C5W C;  4FCX A;  1HPU A;  1S3M A;  3AUZ A;  2NYL C;  2O8G A;  3QFN A;  2QFP A;  1MF8 A;  2GJU A;  1IT6 A;  4UWQ A;  2P6B A;  2NXF A;  1G5B A;  3H62 B;  2YVT A;  4O4K A;  3DSC A;  4Q7F A;  4DHL A;  4NZV A;  3IB8 A;  3ZTV A;  3EGH A;  1T70 A;  5EQV A;  3N5U A;  1WAR A;  4MOY A;  3PSO A;  3QFM A;  1NNW A;  2NYM C;  1Z2W A;  1JK7 A;  3T1I A;  4KKZ A;  2BQ8 X;  1XZW A;  2HYO A;  2Q8U A;  3H68 A;  3H63 A;  1M63 A;  5IOH A;  5GTU A;  3IVE A;  3P71 C;  5C1V A;  3V4Y A;  2KKN A;  1S8E A;  1OI8 A;  2IAE C;  3JYF A;  3THO B;  2Z06 A;  4H2G A;  5INB A;  4UT2 A;  2WDE A;  4TUI A;  1OIE A;  1SU1 A;  3RL5 A;  4UT3 A;  2WDF A;  1WAO 1;  4V0X A;  4IL1 A;  1S70 A;  3H67 A;  4ORA A;  4I5N C;  2Z1A A;  4UT3 B;  1U32 A;  2R17 A;  3GVE A;  4M0V A;  4LTY A;  1Z2X A;  1II7 A;  1AUI A;  3TGH A;  3QFK A;  3EGG A;  4YKE A;  3IVD A;  3H60 A;  4JA7 A;  3ZU0 A;  5JPE A;  4LAC C;  1W24 A;  1QHW A;  3K7W C;  4ZX2 A;  2ZBM A;  2HYP A;  4WWL A;  5JJT A;  3AV0 A;  4G9J A;  4ORB A;  4V0V A;  2XMO A;  5J28 A;  1S3L A;  1T71 A;  4MP0 A;  4B2O A;  3IB7 A;  3ICF A;  4TUG A;  3H66 A;  2BCD A;  4HD0 A;  4ORC A;  4IYP C;  2DFJ A;  1KBP A;  2A22 A;  3PSN A;  4O24 A;  4ZVZ A;  4OR9 A;  3RL3 A;  3RQZ A;  3CK2 A;  3THN A;  4H1Y P;  4DT2 A;  1USH A;  4F0Z A;  2IE4 C;  3QFO A;  3E7B A;  1HP1 A;  1V73 A;  2QJC A;  2WDD A;  4JA9 A;  4XPN A;  3DSD A;  5F3W A;  4O43 A;  4LU9 A; 
#chains in the Genus database with same CATH topology
 2O8A A;  2IE3 C;  1OID A;  4H1S A;  2CV9 A;  5HPE A;  1FJM A;  3H64 A;  3K7V C;  4MOV A;  3FGA C;  4H2I A;  4KBP A;  1S3N A;  4V0W A;  1HO5 A;  1S95 A;  3E0J A;  4H2F A;  2Z72 A;  4H2B A;  2NPP C;  3H69 A;  2USH A;  3QG5 C;  4I5L C;  5B8I A;  2WDC A;  3HVQ A;  3LL8 A;  2JOG A;  2HY1 A;  3DW8 C;  4J6O A;  1XM7 A;  4FBK A;  3KBP A;  2AHD A;  4O5G A;  1UTE A;  4DSY A;  3RL4 A;  2BDX A;  3C9F A;  5DNY A;  5JPF A;  1UF3 A;  4FBQ A;  1QFC A;  4FBW A;  2QFR A;  1TCO A;  3E7A A;  3H61 A;  3C5W C;  4FCX A;  1HPU A;  1S3M A;  3AUZ A;  2NYL C;  2O8G A;  3QFN A;  2QFP A;  1MF8 A;  2GJU A;  1IT6 A;  4UWQ A;  2P6B A;  2NXF A;  4LU9 A;  1G5B A;  3H62 B;  2YVT A;  4O4K A;  3DSC A;  4Q7F A;  4DHL A;  4NZV A;  3IB8 A;  3ZTV A;  3EGH A;  1T70 A;  5EQV A;  3N5U A;  2DXN A;  1WAR A;  4MOY A;  3PSO A;  3QFM A;  1NNW A;  2NYM C;  1Z2W A;  1JK7 A;  3T1I A;  4KKZ A;  2BQ8 X;  1XZW A;  2HYO A;  2Q8U A;  3H68 A;  3H63 A;  1M63 A;  5IOH A;  5GTU A;  3IVE A;  3P71 C;  3D03 A;  5C1V A;  3V4Y A;  2KKN A;  1S8E A;  1OI8 A;  2IAE C;  3JYF A;  3THO B;  2Z06 A;  4H2G A;  5INB A;  4UT2 A;  2WDE A;  4TUI A;  1OIE A;  1SU1 A;  2ZO9 B;  3RL5 A;  2WDF A;  4UT3 A;  1WAO 1;  4V0X A;  4IL1 A;  1S70 A;  3H67 A;  4ORA A;  4I5N C;  2Z1A A;  4UT3 B;  1U32 A;  2R17 A;  3GVE A;  4M0V A;  4LTY A;  1Z2X A;  1II7 A;  1AUI A;  3FLO A;  3TGH A;  3QFK A;  3EGG A;  4YKE A;  3IVD A;  3H60 A;  4JA7 A;  3ZU0 A;  5JPE A;  4LAC C;  1W24 A;  1QHW A;  3K7W C;  4ZX2 A;  2ZBM A;  2HYP A;  2ZOA A;  4WWL A;  5JJT A;  3AV0 A;  4G9J A;  4ORB A;  4V0V A;  2XMO A;  5J28 A;  1S3L A;  1T71 A;  4MP0 A;  4B2O A;  2DXL A;  3IB7 A;  3ICF A;  4TUG A;  3H66 A;  2BCD A;  4HD0 A;  4ORC A;  4IYP C;  2DFJ A;  1KBP A;  2A22 A;  3PSN A;  4O24 A;  4ZVZ A;  4OR9 A;  3RL3 A;  3RQZ A;  3CK2 A;  3THN A;  4H1Y P;  4DT2 A;  1USH A;  4F0Z A;  2IE4 C;  3QFO A;  3E7B A;  1HP1 A;  1V73 A;  2QJC A;  2WDD A;  4JA9 A;  4XPN A;  3DSD A;  5F3W A;  4O43 A;  2YEQ A; 
#chains in the Genus database with same CATH homology
 2O8A A;  2IE3 C;  1OID A;  4H1S A;  2CV9 A;  5HPE A;  1FJM A;  3H64 A;  3K7V C;  4MOV A;  3FGA C;  4H2I A;  4KBP A;  1S3N A;  4V0W A;  1HO5 A;  1S95 A;  3E0J A;  4H2F A;  2Z72 A;  4H2B A;  2NPP C;  3H69 A;  2USH A;  3QG5 C;  4I5L C;  5B8I A;  2WDC A;  3HVQ A;  3LL8 A;  2JOG A;  2HY1 A;  3DW8 C;  4J6O A;  1XM7 A;  4FBK A;  3KBP A;  2AHD A;  4O5G A;  1UTE A;  4DSY A;  3RL4 A;  2BDX A;  3C9F A;  5DNY A;  5JPF A;  1UF3 A;  4FBQ A;  1QFC A;  4FBW A;  2QFR A;  1TCO A;  3E7A A;  3H61 A;  3C5W C;  4FCX A;  1HPU A;  1S3M A;  3AUZ A;  2NYL C;  2O8G A;  3QFN A;  2QFP A;  1MF8 A;  2GJU A;  1IT6 A;  4UWQ A;  2P6B A;  2NXF A;  4LU9 A;  1G5B A;  3H62 B;  2YVT A;  4O4K A;  3DSC A;  4Q7F A;  4DHL A;  4NZV A;  3IB8 A;  3ZTV A;  3EGH A;  1T70 A;  5EQV A;  3N5U A;  2DXN A;  1WAR A;  4MOY A;  3PSO A;  3QFM A;  1NNW A;  2NYM C;  1Z2W A;  1JK7 A;  3T1I A;  4KKZ A;  2BQ8 X;  1XZW A;  2HYO A;  2Q8U A;  3H68 A;  3H63 A;  1M63 A;  5IOH A;  5GTU A;  3IVE A;  3P71 C;  3D03 A;  5C1V A;  3V4Y A;  2KKN A;  1S8E A;  1OI8 A;  2IAE C;  3JYF A;  3THO B;  2Z06 A;  4H2G A;  5INB A;  4UT2 A;  2WDE A;  4TUI A;  1OIE A;  1SU1 A;  2ZO9 B;  3RL5 A;  2WDF A;  4UT3 A;  1WAO 1;  4V0X A;  4IL1 A;  1S70 A;  3H67 A;  4ORA A;  4I5N C;  2Z1A A;  4UT3 B;  1U32 A;  2R17 A;  3GVE A;  4M0V A;  4LTY A;  1Z2X A;  1II7 A;  1AUI A;  3FLO A;  3TGH A;  3QFK A;  3EGG A;  4YKE A;  3IVD A;  3H60 A;  4JA7 A;  3ZU0 A;  5JPE A;  4LAC C;  1W24 A;  1QHW A;  3K7W C;  4ZX2 A;  2ZBM A;  2HYP A;  2ZOA A;  4WWL A;  5JJT A;  3AV0 A;  4G9J A;  4ORB A;  4V0V A;  2XMO A;  5J28 A;  1S3L A;  1T71 A;  4MP0 A;  4B2O A;  2DXL A;  3IB7 A;  3ICF A;  4TUG A;  3H66 A;  2BCD A;  4HD0 A;  4ORC A;  4IYP C;  2DFJ A;  1KBP A;  2A22 A;  3PSN A;  4O24 A;  4ZVZ A;  4OR9 A;  3RL3 A;  3RQZ A;  3CK2 A;  3THN A;  4H1Y P;  4DT2 A;  1USH A;  4F0Z A;  2IE4 C;  3QFO A;  3E7B A;  1HP1 A;  1V73 A;  2QJC A;  2WDD A;  4JA9 A;  4XPN A;  3DSD A;  5F3W A;  4O43 A;  2YEQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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