2BQ8X

Crystal structure of human purple acid phosphatase with an inhibitory conformation of the repression loop
Total Genus 103
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
103
sequence length
304
structure length
304
Chain Sequence
ATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQETFEDVFSDRSLRKVPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSDDFLSQQPERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLVKQLRPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSKRHQRKVPNGYLRFHYGTEDSLGGFAYVEISSKEMTVTYIEASGKSLFKTRLPRRARP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5
publication title Crystal Structures of Recombinant Human Purple Acid Phosphatase with and without an Inhibitory Conformation of the Repression Loop.
pubmed doi rcsb
source organism Homo sapiens
total genus 103
structure length 304
sequence length 304
ec nomenclature ec 3.1.3.2: Acid phosphatase.
pdb deposition date 2005-04-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2bq8X00
4FBKA 5DNYA 2NYMC 1G5BA 2AHDA 3QG5C 3AUZA 2BCDA 1SU1A 4ORAA 3N5UA 5J28A 3AV0A 3H63A 2WDEA 3LL8A 4MP0A 4O24A 5HPEA 1AUIA 3ZTVA 5B8IA 1NNWA 1HO5A 3QFNA 2Z1AA 4LTYA 3THNA 3KBPA 3IB8A 1TCOA 1S95A 4H2GA 2Z72A 4H1SA 3ZU0A 4DHLA 5JPFA 4XPNA 2KKNA 3H69A 1HP1A 2IE3C 3C9FA 1USHA 1S3LA 1S8EA 4O43A 1S3NA 3H60A 3K7WC 4O4KA 4IL1A 4LU9A 2NXFA 1XM7A 2GJUA 4FBWA 3E7AA 2HY1A 4KBPA 1WAO1 2BQ8X 2IE4C 4F0ZA 2BDXA 2USHA 4IYPC 1Z2XA 3H64A 2IAEC 2NYLC 3QFOA 4G9JA 4H2FA 1FJMA 4V0XA 2WDCA 3IVDA 4UWQA 3RL4A 2P6BA 3JYFA 1IT6A 2DFJA 1S70A 4Q7FA 4DT2A 1QFCA 5GTUA 3THOB 2XMOA 1T70A 4LACC 2WDDA 5F3WA 4OR9A 4TUIA 1UF3A 3K7VC 3RQZA 1JK7A 4H2IA 2NPPC 1XZWA 2WDFA 1MF8A 3IVEA 4ORCA 4V0WA 4ORBA 4ZVZA 4DSYA 3IB7A 4YKEA 3EGHA 3DSDA 2JOGA 2A22A 3H62B 4KKZA 3H68A 5JPEA 3V4YA 3EGGA 2ZBMA 1UTEA 4TUGA 1II7A 1WARA 4HD0A 5JJTA 2Q8UA 4MOYA 1HPUA 2Z06A 1QHWA 4FCXA 4B2OA 1T71A 3H67A 3TGHA 1S3MA 2QFRA 3C5WC 3P71C 1U32A 2YVTA 4NZVA 2CV9A 4UT2A 4V0VA 1Z2WA 3DW8C 4ZX2A 2HYOA 4UT3A 4J6OA 5IOHA 3ICFA 2O8AA 3GVEA 2QJCA 4JA9A 3H66A 1OIEA 1M63A 3H61A 3QFMA 4I5LC 1OIDA 3PSOA 4H1YP 3T1IA 4H2BA 1KBPA 4WWLA 3E7BA 4I5NC 3QFKA 5C1VA 4JA7A 2HYPA 4O5GA 2QFPA 1OI8A 1W24A 5EQVA 3FGAC 4MOVA 4FBQA 3RL5A 3HVQA 5INBA 2O8GA 2R17A 4UT3B 3CK2A 1V73A 3DSCA 4M0VA 3PSNA 3RL3A
chains in the Genus database with same CATH superfamily
4FBKA 5DNYA 2NYMC 1G5BA 2AHDA 3QG5C 3AUZA 2BCDA 1SU1A 4ORAA 3N5UA 5J28A 3AV0A 3H63A 2WDEA 3LL8A 4MP0A 4O24A 5HPEA 1AUIA 3ZTVA 2ZOAA 1NNWA 1HO5A 3FLOA 3QFNA 2Z1AA 4LTYA 5B8IA 3THNA 3KBPA 3IB8A 1TCOA 1S95A 4H2GA 2Z72A 4H1SA 3ZU0A 4DHLA 5JPFA 4XPNA 2KKNA 3H69A 1HP1A 2IE3C 2DXNA 3C9FA 1USHA 1S3LA 1S8EA 4O43A 1S3NA 3H60A 3K7WC 4O4KA 4IL1A 4LU9A 2NXFA 1XM7A 2GJUA 4FBWA 3E7AA 2HY1A 4KBPA 1WAO1 2BQ8X 2IE4C 4F0ZA 2YEQA 2BDXA 2USHA 4IYPC 1Z2XA 3H64A 2IAEC 2NYLC 3QFOA 4G9JA 4H2FA 1FJMA 4V0XA 2WDCA 3IVDA 4UWQA 3RL4A 2P6BA 3JYFA 1IT6A 2DFJA 1S70A 4Q7FA 4DT2A 1QFCA 5GTUA 3THOB 2XMOA 1T70A 4LACC 2WDDA 5F3WA 4OR9A 4TUIA 1UF3A 3K7VC 3RQZA 1JK7A 4H2IA 2NPPC 1XZWA 2WDFA 1MF8A 3IVEA 4ORCA 4V0WA 4ORBA 4ZVZA 4DSYA 3IB7A 4YKEA 2ZO9B 3EGHA 3DSDA 2JOGA 2A22A 3H62B 4KKZA 3H68A 5JPEA 3V4YA 3EGGA 2ZBMA 1UTEA 4TUGA 1II7A 1WARA 4HD0A 5JJTA 2Q8UA 4MOYA 1HPUA 2Z06A 1QHWA 4FCXA 4B2OA 1T71A 3H67A 3TGHA 3D03A 1S3MA 2QFRA 3C5WC 3P71C 1U32A 2YVTA 4NZVA 2CV9A 4UT2A 4V0VA 3E0JA 1Z2WA 2DXLA 3DW8C 4ZX2A 2HYOA 4UT3A 4J6OA 5IOHA 3ICFA 2O8AA 3GVEA 2QJCA 4JA9A 3H66A 1OIEA 1M63A 3H61A 3QFMA 4I5LC 1OIDA 3PSOA 4H1YP 3T1IA 4H2BA 1KBPA 4WWLA 3E7BA 4I5NC 3QFKA 5C1VA 4JA7A 2HYPA 4O5GA 2QFPA 1OI8A 1W24A 5EQVA 3FGAC 4MOVA 4FBQA 3RL5A 3HVQA 5INBA 2O8GA 2R17A 4UT3B 3CK2A 1V73A 3DSCA 4M0VA 3PSNA 3RL3A
chains in the Genus database with same CATH topology
4FBKA 5DNYA 2NYMC 1G5BA 2AHDA 3QG5C 3AUZA 2BCDA 1SU1A 4ORAA 3N5UA 5J28A 3AV0A 3H63A 2WDEA 3LL8A 4MP0A 4O24A 5HPEA 1AUIA 3ZTVA 2ZOAA 1NNWA 1HO5A 3FLOA 3QFNA 2Z1AA 4LTYA 5B8IA 3THNA 3KBPA 3IB8A 1TCOA 1S95A 4H2GA 2Z72A 4H1SA 3ZU0A 4DHLA 5JPFA 4XPNA 2KKNA 3H69A 1HP1A 2IE3C 2DXNA 3C9FA 1USHA 1S3LA 1S8EA 4O43A 1S3NA 3H60A 3K7WC 4O4KA 4IL1A 4LU9A 2NXFA 1XM7A 2GJUA 4FBWA 3E7AA 2HY1A 4KBPA 1WAO1 2BQ8X 2IE4C 4F0ZA 2YEQA 2BDXA 2USHA 4IYPC 1Z2XA 3H64A 2IAEC 2NYLC 3QFOA 4G9JA 4H2FA 1FJMA 4V0XA 2WDCA 3IVDA 4UWQA 3RL4A 2P6BA 3JYFA 1IT6A 2DFJA 1S70A 4Q7FA 4DT2A 1QFCA 5GTUA 3THOB 2XMOA 1T70A 4LACC 2WDDA 5F3WA 4OR9A 4TUIA 1UF3A 3K7VC 3RQZA 1JK7A 4H2IA 2NPPC 1XZWA 2WDFA 1MF8A 3IVEA 4ORCA 4V0WA 4ORBA 4ZVZA 4DSYA 3IB7A 4YKEA 2ZO9B 3EGHA 3DSDA 2JOGA 2A22A 3H62B 4KKZA 3H68A 5JPEA 3V4YA 3EGGA 2ZBMA 1UTEA 4TUGA 1II7A 1WARA 4HD0A 5JJTA 2Q8UA 4MOYA 1HPUA 2Z06A 1QHWA 4FCXA 4B2OA 1T71A 3H67A 3TGHA 3D03A 1S3MA 2QFRA 3C5WC 3P71C 1U32A 2YVTA 4NZVA 2CV9A 4UT2A 4V0VA 3E0JA 1Z2WA 2DXLA 3DW8C 4ZX2A 2HYOA 4UT3A 4J6OA 5IOHA 3ICFA 2O8AA 3GVEA 2QJCA 4JA9A 3H66A 1OIEA 1M63A 3H61A 3QFMA 4I5LC 1OIDA 3PSOA 4H1YP 3T1IA 4H2BA 1KBPA 4WWLA 3E7BA 4I5NC 3QFKA 5C1VA 4JA7A 2HYPA 4O5GA 2QFPA 1OI8A 1W24A 5EQVA 3FGAC 4MOVA 4FBQA 3RL5A 3HVQA 5INBA 2O8GA 2R17A 4UT3B 3CK2A 1V73A 3DSCA 4M0VA 3PSNA 3RL3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FBK A;  5DNY A;  2NYM C;  1G5B A;  2AHD A;  3QG5 C;  3AUZ A;  2BCD A;  1SU1 A;  4ORA A;  3N5U A;  5J28 A;  3AV0 A;  3H63 A;  2WDE A;  3LL8 A;  4MP0 A;  4O24 A;  5HPE A;  1AUI A;  3ZTV A;  5B8I A;  1NNW A;  1HO5 A;  3QFN A;  2Z1A A;  4LTY A;  3THN A;  3KBP A;  3IB8 A;  1TCO A;  1S95 A;  4H2G A;  2Z72 A;  4H1S A;  3ZU0 A;  4DHL A;  5JPF A;  4XPN A;  2KKN A;  3H69 A;  1HP1 A;  2IE3 C;  3C9F A;  1USH A;  1S3L A;  1S8E A;  4O43 A;  1S3N A;  3H60 A;  3K7W C;  4O4K A;  4IL1 A;  4LU9 A;  2NXF A;  1XM7 A;  2GJU A;  4FBW A;  3E7A A;  2HY1 A;  4KBP A;  1WAO 1;  2BQ8 X;  2IE4 C;  4F0Z A;  2BDX A;  2USH A;  4IYP C;  1Z2X A;  3H64 A;  2IAE C;  2NYL C;  3QFO A;  4G9J A;  4H2F A;  1FJM A;  4V0X A;  2WDC A;  3IVD A;  4UWQ A;  3RL4 A;  2P6B A;  3JYF A;  1IT6 A;  2DFJ A;  1S70 A;  4Q7F A;  4DT2 A;  1QFC A;  5GTU A;  3THO B;  2XMO A;  1T70 A;  4LAC C;  2WDD A;  5F3W A;  4OR9 A;  4TUI A;  1UF3 A;  3K7V C;  3RQZ A;  1JK7 A;  4H2I A;  2NPP C;  1XZW A;  2WDF A;  1MF8 A;  3IVE A;  4ORC A;  4V0W A;  4ORB A;  4ZVZ A;  4DSY A;  3IB7 A;  4YKE A;  3EGH A;  3DSD A;  2JOG A;  2A22 A;  3H62 B;  4KKZ A;  3H68 A;  5JPE A;  3V4Y A;  3EGG A;  2ZBM A;  1UTE A;  4TUG A;  1II7 A;  1WAR A;  4HD0 A;  5JJT A;  2Q8U A;  4MOY A;  1HPU A;  2Z06 A;  1QHW A;  4FCX A;  4B2O A;  1T71 A;  3H67 A;  3TGH A;  1S3M A;  2QFR A;  3C5W C;  3P71 C;  1U32 A;  2YVT A;  4NZV A;  2CV9 A;  4UT2 A;  4V0V A;  1Z2W A;  3DW8 C;  4ZX2 A;  2HYO A;  4UT3 A;  4J6O A;  5IOH A;  3ICF A;  2O8A A;  3GVE A;  2QJC A;  4JA9 A;  3H66 A;  1OIE A;  1M63 A;  3H61 A;  3QFM A;  4I5L C;  1OID A;  3PSO A;  4H1Y P;  3T1I A;  4H2B A;  1KBP A;  4WWL A;  3E7B A;  4I5N C;  3QFK A;  5C1V A;  4JA7 A;  2HYP A;  4O5G A;  2QFP A;  1OI8 A;  1W24 A;  5EQV A;  3FGA C;  4MOV A;  4FBQ A;  3RL5 A;  3HVQ A;  5INB A;  2O8G A;  2R17 A;  4UT3 B;  3CK2 A;  1V73 A;  3DSC A;  4M0V A;  3PSN A;  3RL3 A; 
#chains in the Genus database with same CATH topology
 4FBK A;  5DNY A;  2NYM C;  1G5B A;  2AHD A;  3QG5 C;  3AUZ A;  2BCD A;  1SU1 A;  4ORA A;  3N5U A;  5J28 A;  3AV0 A;  3H63 A;  2WDE A;  3LL8 A;  4MP0 A;  4O24 A;  5HPE A;  1AUI A;  3ZTV A;  2ZOA A;  1NNW A;  1HO5 A;  3FLO A;  3QFN A;  2Z1A A;  4LTY A;  5B8I A;  3THN A;  3KBP A;  3IB8 A;  1TCO A;  1S95 A;  4H2G A;  2Z72 A;  4H1S A;  3ZU0 A;  4DHL A;  5JPF A;  4XPN A;  2KKN A;  3H69 A;  1HP1 A;  2IE3 C;  2DXN A;  3C9F A;  1USH A;  1S3L A;  1S8E A;  4O43 A;  1S3N A;  3H60 A;  3K7W C;  4O4K A;  4IL1 A;  4LU9 A;  2NXF A;  1XM7 A;  2GJU A;  4FBW A;  3E7A A;  2HY1 A;  4KBP A;  1WAO 1;  2BQ8 X;  2IE4 C;  4F0Z A;  2YEQ A;  2BDX A;  2USH A;  4IYP C;  1Z2X A;  3H64 A;  2IAE C;  2NYL C;  3QFO A;  4G9J A;  4H2F A;  1FJM A;  4V0X A;  2WDC A;  3IVD A;  4UWQ A;  3RL4 A;  2P6B A;  3JYF A;  1IT6 A;  2DFJ A;  1S70 A;  4Q7F A;  4DT2 A;  1QFC A;  5GTU A;  3THO B;  2XMO A;  1T70 A;  4LAC C;  2WDD A;  5F3W A;  4OR9 A;  4TUI A;  1UF3 A;  3K7V C;  3RQZ A;  1JK7 A;  4H2I A;  2NPP C;  1XZW A;  2WDF A;  1MF8 A;  3IVE A;  4ORC A;  4V0W A;  4ORB A;  4ZVZ A;  4DSY A;  3IB7 A;  4YKE A;  2ZO9 B;  3EGH A;  3DSD A;  2JOG A;  2A22 A;  3H62 B;  4KKZ A;  3H68 A;  5JPE A;  3V4Y A;  3EGG A;  2ZBM A;  1UTE A;  4TUG A;  1II7 A;  1WAR A;  4HD0 A;  5JJT A;  2Q8U A;  4MOY A;  1HPU A;  2Z06 A;  1QHW A;  4FCX A;  4B2O A;  1T71 A;  3H67 A;  3TGH A;  3D03 A;  1S3M A;  2QFR A;  3C5W C;  3P71 C;  1U32 A;  2YVT A;  4NZV A;  2CV9 A;  4UT2 A;  4V0V A;  3E0J A;  1Z2W A;  2DXL A;  3DW8 C;  4ZX2 A;  2HYO A;  4UT3 A;  4J6O A;  5IOH A;  3ICF A;  2O8A A;  3GVE A;  2QJC A;  4JA9 A;  3H66 A;  1OIE A;  1M63 A;  3H61 A;  3QFM A;  4I5L C;  1OID A;  3PSO A;  4H1Y P;  3T1I A;  4H2B A;  1KBP A;  4WWL A;  3E7B A;  4I5N C;  3QFK A;  5C1V A;  4JA7 A;  2HYP A;  4O5G A;  2QFP A;  1OI8 A;  1W24 A;  5EQV A;  3FGA C;  4MOV A;  4FBQ A;  3RL5 A;  3HVQ A;  5INB A;  2O8G A;  2R17 A;  4UT3 B;  3CK2 A;  1V73 A;  3DSC A;  4M0V A;  3PSN A;  3RL3 A; 
#chains in the Genus database with same CATH homology
 4FBK A;  5DNY A;  2NYM C;  1G5B A;  2AHD A;  3QG5 C;  3AUZ A;  2BCD A;  1SU1 A;  4ORA A;  3N5U A;  5J28 A;  3AV0 A;  3H63 A;  2WDE A;  3LL8 A;  4MP0 A;  4O24 A;  5HPE A;  1AUI A;  3ZTV A;  2ZOA A;  1NNW A;  1HO5 A;  3FLO A;  3QFN A;  2Z1A A;  4LTY A;  5B8I A;  3THN A;  3KBP A;  3IB8 A;  1TCO A;  1S95 A;  4H2G A;  2Z72 A;  4H1S A;  3ZU0 A;  4DHL A;  5JPF A;  4XPN A;  2KKN A;  3H69 A;  1HP1 A;  2IE3 C;  2DXN A;  3C9F A;  1USH A;  1S3L A;  1S8E A;  4O43 A;  1S3N A;  3H60 A;  3K7W C;  4O4K A;  4IL1 A;  4LU9 A;  2NXF A;  1XM7 A;  2GJU A;  4FBW A;  3E7A A;  2HY1 A;  4KBP A;  1WAO 1;  2BQ8 X;  2IE4 C;  4F0Z A;  2YEQ A;  2BDX A;  2USH A;  4IYP C;  1Z2X A;  3H64 A;  2IAE C;  2NYL C;  3QFO A;  4G9J A;  4H2F A;  1FJM A;  4V0X A;  2WDC A;  3IVD A;  4UWQ A;  3RL4 A;  2P6B A;  3JYF A;  1IT6 A;  2DFJ A;  1S70 A;  4Q7F A;  4DT2 A;  1QFC A;  5GTU A;  3THO B;  2XMO A;  1T70 A;  4LAC C;  2WDD A;  5F3W A;  4OR9 A;  4TUI A;  1UF3 A;  3K7V C;  3RQZ A;  1JK7 A;  4H2I A;  2NPP C;  1XZW A;  2WDF A;  1MF8 A;  3IVE A;  4ORC A;  4V0W A;  4ORB A;  4ZVZ A;  4DSY A;  3IB7 A;  4YKE A;  2ZO9 B;  3EGH A;  3DSD A;  2JOG A;  2A22 A;  3H62 B;  4KKZ A;  3H68 A;  5JPE A;  3V4Y A;  3EGG A;  2ZBM A;  1UTE A;  4TUG A;  1II7 A;  1WAR A;  4HD0 A;  5JJT A;  2Q8U A;  4MOY A;  1HPU A;  2Z06 A;  1QHW A;  4FCX A;  4B2O A;  1T71 A;  3H67 A;  3TGH A;  3D03 A;  1S3M A;  2QFR A;  3C5W C;  3P71 C;  1U32 A;  2YVT A;  4NZV A;  2CV9 A;  4UT2 A;  4V0V A;  3E0J A;  1Z2W A;  2DXL A;  3DW8 C;  4ZX2 A;  2HYO A;  4UT3 A;  4J6O A;  5IOH A;  3ICF A;  2O8A A;  3GVE A;  2QJC A;  4JA9 A;  3H66 A;  1OIE A;  1M63 A;  3H61 A;  3QFM A;  4I5L C;  1OID A;  3PSO A;  4H1Y P;  3T1I A;  4H2B A;  1KBP A;  4WWL A;  3E7B A;  4I5N C;  3QFK A;  5C1V A;  4JA7 A;  2HYP A;  4O5G A;  2QFP A;  1OI8 A;  1W24 A;  5EQV A;  3FGA C;  4MOV A;  4FBQ A;  3RL5 A;  3HVQ A;  5INB A;  2O8G A;  2R17 A;  4UT3 B;  3CK2 A;  1V73 A;  3DSC A;  4M0V A;  3PSN A;  3RL3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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