4H2IA

Human ecto-5'-nucleotidase (cd73): crystal form iii (closed) in complex with ampcp
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
524
structure length
524
Chain Sequence
MWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHADEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords 5'-nucleotidase
publication title Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling.
pubmed doi rcsb
source organism Homo sapiens
total genus 177
structure length 524
sequence length 524
ec nomenclature ec 3.1.3.5: 5'-nucleotidase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF02872 5_nucleotid_C 5'-nucleotidase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4h2iA01
3.90.780.10 Alpha Beta Alpha-Beta Complex 5'-nucleotidase; domain 2 5'-Nucleotidase, C-terminal domain 4h2iA02
3C5WC 4JA7A 1T71A 3K7VC 4I5LC 4DT2A 1HPUA 1T70A 2A22A 3FGAC 4FBQA 3QG5C 4ORBA 1JK7A 2NYMC 2WDFA 3KBPA 2ZBMA 2Z1AA 3AV0A 1KBPA 5JJTA 1W24A 3H68A 3N5UA 1S3LA 5F3WA 1FJMA 4YKEA 3DSDA 1UF3A 1SU1A 3ICFA 4UWQA 1OI8A 2BQ8X 3IB8A 3THOB 3LL8A 1G5BA 4O4KA 2USHA 2NYLC 3IVDA 3RL4A 2WDCA 3DW8C 1HP1A 3IVEA 4H2FA 4J6OA 4G9JA 5C1VA 4DSYA 4I5NC 4O43A 3RL3A 4B2OA 3GVEA 2DFJA 3H67A 3H63A 4IYPC 4FCXA 3E7BA 4IL1A 4WWLA 3HVQA 2QFPA 3PSOA 5INBA 4M0VA 2GJUA 2YVTA 2O8AA 1OIDA 1USHA 3P71C 5GTUA 2BDXA 4KBPA 4OR9A 5JPFA 3H66A 3E7AA 3CK2A 2JOGA 2Z06A 4MOYA 1TCOA 2IE3C 5DNYA 1NNWA 2P6BA 1XZWA 2QFRA 4H2GA 4UT2A 3RQZA 1UTEA 3QFMA 3T1IA 5B8IA 4NZVA 3DSCA 2HY1A 4V0WA 2Q8UA 4MOVA 3QFKA 2Z72A 4V0VA 3JYFA 3TGHA 1V73A 2NPPC 4O24A 4F0ZA 1Z2WA 3QFNA 4DHLA 1S8EA 4FBKA 2WDEA 5HPEA 4UT3B 4XPNA 3QFOA 4ZX2A 1Z2XA 2XMOA 4LU9A 4LACC 3V4YA 4ORCA 3EGHA 3H62B 1OIEA 2BCDA 1AUIA 1WARA 4H1SA 4Q7FA 4TUIA 2WDDA 4LTYA 2HYOA 3RL5A 2CV9A 1QFCA 3EGGA 1S70A 4HD0A 1WAO1 3C9FA 4FBWA 3ZU0A 1IT6A 2O8GA 4H2IA 4ORAA 3THNA 4JA9A 3ZTVA 1S3NA 2QJCA 3H61A 2IAEC 3PSNA 1M63A 2NXFA 4ZVZA 1S95A 3AUZA 4H2BA 3H60A 2KKNA 2HYPA 1MF8A 1S3MA 3H69A 4V0XA 1HO5A 4H1YP 5JPEA 1II7A 2IE4C 4O5GA 4KKZA 5EQVA 3H64A 4UT3A 4MP0A 5J28A 4TUGA 2AHDA 1XM7A 3K7WC 2R17A 5IOHA 3IB7A 1QHWA 1U32A
chains in the Genus database with same CATH superfamily
3C5WC 4JA7A 1T71A 3D03A 3K7VC 4I5LC 4DT2A 1HPUA 1T70A 2A22A 3FGAC 4FBQA 3QG5C 4ORBA 1JK7A 2NYMC 2WDFA 3KBPA 2ZBMA 2Z1AA 3AV0A 1KBPA 5JJTA 1W24A 3H68A 3N5UA 1S3LA 5F3WA 1FJMA 4YKEA 3DSDA 1UF3A 1SU1A 3ICFA 2ZO9B 2ZOAA 1OI8A 2BQ8X 3IB8A 4UWQA 3THOB 3LL8A 1G5BA 4O4KA 2USHA 2NYLC 3IVDA 3RL4A 2WDCA 3DW8C 1HP1A 3IVEA 4H2FA 4J6OA 4G9JA 5C1VA 4DSYA 4I5NC 4O43A 3RL3A 4B2OA 3GVEA 2DFJA 3H67A 3H63A 4IYPC 4FCXA 3E7BA 4IL1A 4WWLA 3HVQA 2QFPA 3PSOA 5INBA 4M0VA 2GJUA 2YVTA 2O8AA 1OIDA 3FLOA 1USHA 3P71C 5GTUA 2BDXA 4KBPA 4OR9A 5JPFA 3H66A 3E7AA 3CK2A 3E0JA 2JOGA 2Z06A 4MOYA 1TCOA 2IE3C 5DNYA 1NNWA 2P6BA 1XZWA 2QFRA 4H2GA 4UT2A 3RQZA 1UTEA 3QFMA 3T1IA 5B8IA 4NZVA 3DSCA 2HY1A 4V0WA 2Q8UA 4MOVA 3QFKA 2YEQA 2DXNA 2Z72A 4V0VA 3JYFA 2DXLA 3TGHA 1V73A 2NPPC 4O24A 4F0ZA 1Z2WA 3QFNA 4DHLA 1S8EA 4FBKA 2WDEA 5HPEA 4UT3B 4XPNA 3QFOA 4ZX2A 1Z2XA 2XMOA 4LU9A 4LACC 3V4YA 4ORCA 3EGHA 3H62B 1OIEA 2BCDA 1AUIA 1WARA 4H1SA 4Q7FA 4TUIA 2WDDA 4LTYA 2HYOA 3RL5A 2CV9A 1QFCA 3EGGA 1S70A 4HD0A 1WAO1 3C9FA 4FBWA 3ZU0A 1IT6A 2O8GA 4H2IA 4ORAA 3THNA 4JA9A 3ZTVA 1S3NA 2QJCA 3H61A 2IAEC 3PSNA 1M63A 2NXFA 4ZVZA 1S95A 3AUZA 4H2BA 3H60A 2KKNA 2HYPA 1MF8A 1S3MA 3H69A 4V0XA 1HO5A 4H1YP 5JPEA 1II7A 2IE4C 4O5GA 4KKZA 5EQVA 3H64A 4UT3A 4MP0A 5J28A 4TUGA 2AHDA 1XM7A 3K7WC 2R17A 5IOHA 3IB7A 1QHWA 1U32A
chains in the Genus database with same CATH topology
3C5WC 4JA7A 1T71A 3D03A 3K7VC 4I5LC 4DT2A 1HPUA 1T70A 2A22A 3FGAC 4FBQA 3QG5C 4ORBA 1JK7A 2NYMC 2WDFA 3KBPA 2ZBMA 2Z1AA 3AV0A 1KBPA 5JJTA 1W24A 3H68A 3N5UA 1S3LA 5F3WA 1FJMA 4YKEA 3DSDA 1UF3A 1SU1A 3ICFA 2ZO9B 2ZOAA 1OI8A 2BQ8X 3IB8A 4UWQA 3THOB 3LL8A 1G5BA 4O4KA 2USHA 2NYLC 3IVDA 3RL4A 2WDCA 3DW8C 1HP1A 3IVEA 4H2FA 4J6OA 4G9JA 5C1VA 4DSYA 4I5NC 4O43A 3RL3A 4B2OA 3GVEA 2DFJA 3H67A 3H63A 4IYPC 4FCXA 3E7BA 4IL1A 4WWLA 3HVQA 2QFPA 3PSOA 5INBA 4M0VA 2GJUA 2YVTA 2O8AA 1OIDA 3FLOA 1USHA 3P71C 5GTUA 2BDXA 4KBPA 4OR9A 5JPFA 3H66A 3E7AA 3CK2A 3E0JA 2JOGA 2Z06A 4MOYA 1TCOA 2IE3C 5DNYA 1NNWA 2P6BA 1XZWA 2QFRA 4H2GA 4UT2A 3RQZA 1UTEA 3QFMA 3T1IA 5B8IA 4NZVA 3DSCA 2HY1A 4V0WA 2Q8UA 4MOVA 3QFKA 2YEQA 2DXNA 2Z72A 4V0VA 3JYFA 2DXLA 3TGHA 1V73A 2NPPC 4O24A 4F0ZA 1Z2WA 3QFNA 4DHLA 1S8EA 4FBKA 2WDEA 5HPEA 4UT3B 4XPNA 3QFOA 4ZX2A 1Z2XA 2XMOA 4LU9A 4LACC 3V4YA 4ORCA 3EGHA 3H62B 1OIEA 2BCDA 1AUIA 1WARA 4H1SA 4Q7FA 4TUIA 2WDDA 4LTYA 2HYOA 3RL5A 2CV9A 1QFCA 3EGGA 1S70A 4HD0A 1WAO1 3C9FA 4FBWA 3ZU0A 1IT6A 2O8GA 4H2IA 4ORAA 3THNA 4JA9A 3ZTVA 1S3NA 2QJCA 3H61A 2IAEC 3PSNA 1M63A 2NXFA 4ZVZA 1S95A 3AUZA 4H2BA 3H60A 2KKNA 2HYPA 1MF8A 1S3MA 3H69A 4V0XA 1HO5A 4H1YP 5JPEA 1II7A 2IE4C 4O5GA 4KKZA 5EQVA 3H64A 4UT3A 4MP0A 5J28A 4TUGA 2AHDA 1XM7A 3K7WC 2R17A 5IOHA 3IB7A 1QHWA 1U32A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3C5W C;  4JA7 A;  1T71 A;  3K7V C;  4I5L C;  4DT2 A;  1HPU A;  1T70 A;  2A22 A;  3FGA C;  4FBQ A;  3QG5 C;  4ORB A;  1JK7 A;  2NYM C;  2WDF A;  3KBP A;  2ZBM A;  2Z1A A;  3AV0 A;  1KBP A;  5JJT A;  1W24 A;  3H68 A;  3N5U A;  1S3L A;  5F3W A;  1FJM A;  4YKE A;  3DSD A;  1UF3 A;  1SU1 A;  3ICF A;  4UWQ A;  1OI8 A;  2BQ8 X;  3IB8 A;  3THO B;  3LL8 A;  1G5B A;  4O4K A;  2USH A;  2NYL C;  3IVD A;  3RL4 A;  2WDC A;  3DW8 C;  1HP1 A;  3IVE A;  4H2F A;  4J6O A;  4G9J A;  5C1V A;  4DSY A;  4I5N C;  4O43 A;  3RL3 A;  4B2O A;  3GVE A;  2DFJ A;  3H67 A;  3H63 A;  4IYP C;  4FCX A;  3E7B A;  4IL1 A;  4WWL A;  3HVQ A;  2QFP A;  3PSO A;  5INB A;  4M0V A;  2GJU A;  2YVT A;  2O8A A;  1OID A;  1USH A;  3P71 C;  5GTU A;  2BDX A;  4KBP A;  4OR9 A;  5JPF A;  3H66 A;  3E7A A;  3CK2 A;  2JOG A;  2Z06 A;  4MOY A;  1TCO A;  2IE3 C;  5DNY A;  1NNW A;  2P6B A;  1XZW A;  2QFR A;  4H2G A;  4UT2 A;  3RQZ A;  1UTE A;  3QFM A;  3T1I A;  5B8I A;  4NZV A;  3DSC A;  2HY1 A;  4V0W A;  2Q8U A;  4MOV A;  3QFK A;  2Z72 A;  4V0V A;  3JYF A;  3TGH A;  1V73 A;  2NPP C;  4O24 A;  4F0Z A;  1Z2W A;  3QFN A;  4DHL A;  1S8E A;  4FBK A;  2WDE A;  5HPE A;  4UT3 B;  4XPN A;  3QFO A;  4ZX2 A;  1Z2X A;  2XMO A;  4LU9 A;  4LAC C;  3V4Y A;  4ORC A;  3EGH A;  3H62 B;  1OIE A;  2BCD A;  1AUI A;  1WAR A;  4H1S A;  4Q7F A;  4TUI A;  2WDD A;  4LTY A;  2HYO A;  3RL5 A;  2CV9 A;  1QFC A;  3EGG A;  1S70 A;  4HD0 A;  1WAO 1;  3C9F A;  4FBW A;  3ZU0 A;  1IT6 A;  2O8G A;  4H2I A;  4ORA A;  3THN A;  4JA9 A;  3ZTV A;  1S3N A;  2QJC A;  3H61 A;  2IAE C;  3PSN A;  1M63 A;  2NXF A;  4ZVZ A;  1S95 A;  3AUZ A;  4H2B A;  3H60 A;  2KKN A;  2HYP A;  1MF8 A;  1S3M A;  3H69 A;  4V0X A;  1HO5 A;  4H1Y P;  5JPE A;  1II7 A;  2IE4 C;  4O5G A;  4KKZ A;  5EQV A;  3H64 A;  4UT3 A;  4MP0 A;  5J28 A;  4TUG A;  2AHD A;  1XM7 A;  3K7W C;  2R17 A;  5IOH A;  3IB7 A;  1QHW A;  1U32 A; 
#chains in the Genus database with same CATH topology
 3C5W C;  4JA7 A;  1T71 A;  3D03 A;  3K7V C;  4I5L C;  4DT2 A;  1HPU A;  1T70 A;  2A22 A;  3FGA C;  4FBQ A;  3QG5 C;  4ORB A;  1JK7 A;  2NYM C;  2WDF A;  3KBP A;  2ZBM A;  2Z1A A;  3AV0 A;  1KBP A;  5JJT A;  1W24 A;  3H68 A;  3N5U A;  1S3L A;  5F3W A;  1FJM A;  4YKE A;  3DSD A;  1UF3 A;  1SU1 A;  3ICF A;  2ZO9 B;  2ZOA A;  1OI8 A;  2BQ8 X;  3IB8 A;  4UWQ A;  3THO B;  3LL8 A;  1G5B A;  4O4K A;  2USH A;  2NYL C;  3IVD A;  3RL4 A;  2WDC A;  3DW8 C;  1HP1 A;  3IVE A;  4H2F A;  4J6O A;  4G9J A;  5C1V A;  4DSY A;  4I5N C;  4O43 A;  3RL3 A;  4B2O A;  3GVE A;  2DFJ A;  3H67 A;  3H63 A;  4IYP C;  4FCX A;  3E7B A;  4IL1 A;  4WWL A;  3HVQ A;  2QFP A;  3PSO A;  5INB A;  4M0V A;  2GJU A;  2YVT A;  2O8A A;  1OID A;  3FLO A;  1USH A;  3P71 C;  5GTU A;  2BDX A;  4KBP A;  4OR9 A;  5JPF A;  3H66 A;  3E7A A;  3CK2 A;  3E0J A;  2JOG A;  2Z06 A;  4MOY A;  1TCO A;  2IE3 C;  5DNY A;  1NNW A;  2P6B A;  1XZW A;  2QFR A;  4H2G A;  4UT2 A;  3RQZ A;  1UTE A;  3QFM A;  3T1I A;  5B8I A;  4NZV A;  3DSC A;  2HY1 A;  4V0W A;  2Q8U A;  4MOV A;  3QFK A;  2YEQ A;  2DXN A;  2Z72 A;  4V0V A;  3JYF A;  2DXL A;  3TGH A;  1V73 A;  2NPP C;  4O24 A;  4F0Z A;  1Z2W A;  3QFN A;  4DHL A;  1S8E A;  4FBK A;  2WDE A;  5HPE A;  4UT3 B;  4XPN A;  3QFO A;  4ZX2 A;  1Z2X A;  2XMO A;  4LU9 A;  4LAC C;  3V4Y A;  4ORC A;  3EGH A;  3H62 B;  1OIE A;  2BCD A;  1AUI A;  1WAR A;  4H1S A;  4Q7F A;  4TUI A;  2WDD A;  4LTY A;  2HYO A;  3RL5 A;  2CV9 A;  1QFC A;  3EGG A;  1S70 A;  4HD0 A;  1WAO 1;  3C9F A;  4FBW A;  3ZU0 A;  1IT6 A;  2O8G A;  4H2I A;  4ORA A;  3THN A;  4JA9 A;  3ZTV A;  1S3N A;  2QJC A;  3H61 A;  2IAE C;  3PSN A;  1M63 A;  2NXF A;  4ZVZ A;  1S95 A;  3AUZ A;  4H2B A;  3H60 A;  2KKN A;  2HYP A;  1MF8 A;  1S3M A;  3H69 A;  4V0X A;  1HO5 A;  4H1Y P;  5JPE A;  1II7 A;  2IE4 C;  4O5G A;  4KKZ A;  5EQV A;  3H64 A;  4UT3 A;  4MP0 A;  5J28 A;  4TUG A;  2AHD A;  1XM7 A;  3K7W C;  2R17 A;  5IOH A;  3IB7 A;  1QHW A;  1U32 A; 
#chains in the Genus database with same CATH homology
 3C5W C;  4JA7 A;  1T71 A;  3D03 A;  3K7V C;  4I5L C;  4DT2 A;  1HPU A;  1T70 A;  2A22 A;  3FGA C;  4FBQ A;  3QG5 C;  4ORB A;  1JK7 A;  2NYM C;  2WDF A;  3KBP A;  2ZBM A;  2Z1A A;  3AV0 A;  1KBP A;  5JJT A;  1W24 A;  3H68 A;  3N5U A;  1S3L A;  5F3W A;  1FJM A;  4YKE A;  3DSD A;  1UF3 A;  1SU1 A;  3ICF A;  2ZO9 B;  2ZOA A;  1OI8 A;  2BQ8 X;  3IB8 A;  4UWQ A;  3THO B;  3LL8 A;  1G5B A;  4O4K A;  2USH A;  2NYL C;  3IVD A;  3RL4 A;  2WDC A;  3DW8 C;  1HP1 A;  3IVE A;  4H2F A;  4J6O A;  4G9J A;  5C1V A;  4DSY A;  4I5N C;  4O43 A;  3RL3 A;  4B2O A;  3GVE A;  2DFJ A;  3H67 A;  3H63 A;  4IYP C;  4FCX A;  3E7B A;  4IL1 A;  4WWL A;  3HVQ A;  2QFP A;  3PSO A;  5INB A;  4M0V A;  2GJU A;  2YVT A;  2O8A A;  1OID A;  3FLO A;  1USH A;  3P71 C;  5GTU A;  2BDX A;  4KBP A;  4OR9 A;  5JPF A;  3H66 A;  3E7A A;  3CK2 A;  3E0J A;  2JOG A;  2Z06 A;  4MOY A;  1TCO A;  2IE3 C;  5DNY A;  1NNW A;  2P6B A;  1XZW A;  2QFR A;  4H2G A;  4UT2 A;  3RQZ A;  1UTE A;  3QFM A;  3T1I A;  5B8I A;  4NZV A;  3DSC A;  2HY1 A;  4V0W A;  2Q8U A;  4MOV A;  3QFK A;  2YEQ A;  2DXN A;  2Z72 A;  4V0V A;  3JYF A;  2DXL A;  3TGH A;  1V73 A;  2NPP C;  4O24 A;  4F0Z A;  1Z2W A;  3QFN A;  4DHL A;  1S8E A;  4FBK A;  2WDE A;  5HPE A;  4UT3 B;  4XPN A;  3QFO A;  4ZX2 A;  1Z2X A;  2XMO A;  4LU9 A;  4LAC C;  3V4Y A;  4ORC A;  3EGH A;  3H62 B;  1OIE A;  2BCD A;  1AUI A;  1WAR A;  4H1S A;  4Q7F A;  4TUI A;  2WDD A;  4LTY A;  2HYO A;  3RL5 A;  2CV9 A;  1QFC A;  3EGG A;  1S70 A;  4HD0 A;  1WAO 1;  3C9F A;  4FBW A;  3ZU0 A;  1IT6 A;  2O8G A;  4H2I A;  4ORA A;  3THN A;  4JA9 A;  3ZTV A;  1S3N A;  2QJC A;  3H61 A;  2IAE C;  3PSN A;  1M63 A;  2NXF A;  4ZVZ A;  1S95 A;  3AUZ A;  4H2B A;  3H60 A;  2KKN A;  2HYP A;  1MF8 A;  1S3M A;  3H69 A;  4V0X A;  1HO5 A;  4H1Y P;  5JPE A;  1II7 A;  2IE4 C;  4O5G A;  4KKZ A;  5EQV A;  3H64 A;  4UT3 A;  4MP0 A;  5J28 A;  4TUG A;  2AHD A;  1XM7 A;  3K7W C;  2R17 A;  5IOH A;  3IB7 A;  1QHW A;  1U32 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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