4H2IA

Human ecto-5'-nucleotidase (cd73): crystal form iii (closed) in complex with ampcp
Total Genus 177
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
177
sequence length
524
structure length
524
Chain Sequence
MWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHADEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords 5'-nucleotidase
total genus 177
structure length 524
sequence length 524
ec nomenclature ec 3.1.3.5: 5'-nucleotidase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF02872 5_nucleotid_C 5'-nucleotidase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4h2iA01
3.90.780.10 Alpha Beta Alpha-Beta Complex 5'-nucleotidase; domain 2 5'-Nucleotidase, C-terminal domain 4h2iA02
3H66A 2Z72A 2NPPC 2WDFA 3QFOA 3C5WC 1WARA 5C1VA 3V4YA 2HYOA 3ZTVA 2Q8UA 4I5LC 4MOYA 1QHWA 2R17A 3P71C 4O24A 2A22A 1XM7A 4UT3A 3DSCA 2WDCA 1XZWA 4OR9A 2Z06A 2WDEA 4UWQA 1M63A 1IT6A 1HP1A 3QG5C 3LL8A 3E7AA 1NNWA 5JJTA 3IB7A 4XPNA 3RQZA 2BDXA 2DFJA 2KKNA 1KBPA 4HD0A 1OI8A 2NYMC 2O8GA 3RL4A 3ICFA 2QFRA 4H1YP 2BQ8X 4O5GA 1HPUA 4M0VA 3RL5A 3EGGA 1U32A 5EQVA 3IB8A 3DW8C 3JYFA 3HVQA 4G9JA 4KBPA 4JA7A 3K7VC 4O43A 3DSDA 3N5UA 5GTUA 3H61A 1HO5A 2JOGA 1W24A 1T71A 2HY1A 5JPFA 1USHA 3H68A 1JK7A 3FGAC 5B8IA 2ZBMA 1TCOA 4O4KA 3C9FA 4DSYA 4V0WA 2IE4C 4F0ZA 4MP0A 1UTEA 4NZVA 1S95A 1WAO1 1UF3A 3THNA 4B2OA 3AUZA 4FCXA 1G5BA 1OIEA 2O8AA 5DNYA 1Z2XA 3CK2A 3TGHA 4DHLA 4H2GA 1S3MA 3RL3A 4IL1A 4H2FA 4UT3B 2AHDA 4UT2A 4TUGA 3PSOA 2IE3C 2USHA 3IVDA 3GVEA 4IYPC 4MOVA 4LACC 1QFCA 4ZVZA 5HPEA 3H64A 4H2BA 4FBKA 4V0XA 3QFKA 5INBA 4LU9A 3QFMA 2NYLC 5J28A 1S3LA 1Z2WA 3ZU0A 1MF8A 3H67A 2YVTA 1S70A 3T1IA 4FBQA 4YKEA 2WDDA 1S8EA 4FBWA 2XMOA 1FJMA 3KBPA 3E7BA 4I5NC 4Q7FA 5IOHA 2CV9A 3H69A 1OIDA 3AV0A 3H60A 4LTYA 3IVEA 3K7WC 2P6BA 2QJCA 2HYPA 5F3WA 4ZX2A 2NXFA 2IAEC 2GJUA 4WWLA 1V73A 2BCDA 1II7A 4ORCA 4ORBA 3QFNA 4TUIA 4ORAA 1S3NA 1T70A 3H63A 1AUIA 4DT2A 2QFPA 4V0VA 5JPEA 4KKZA 1SU1A 4J6OA 3THOB 2Z1AA 3EGHA 4JA9A 3H62B 4H1SA 3PSNA 4H2IA
chains in the Genus database with same CATH superfamily
3H66A 2Z72A 2NPPC 2WDFA 3QFOA 3C5WC 1WARA 5C1VA 3V4YA 2HYOA 2DXLA 3ZTVA 2Q8UA 4I5LC 4MOYA 1QHWA 2R17A 3P71C 4O24A 2A22A 1XM7A 4UT3A 3DSCA 2WDCA 1XZWA 4OR9A 2Z06A 2WDEA 4UWQA 1M63A 1IT6A 1HP1A 3QG5C 3LL8A 3E7AA 1NNWA 5JJTA 3E0JA 3IB7A 4XPNA 3RQZA 2BDXA 2DFJA 2KKNA 1KBPA 4HD0A 1OI8A 2NYMC 2O8GA 3RL4A 3ICFA 2QFRA 4H1YP 2BQ8X 4O5GA 1HPUA 4M0VA 3RL5A 3EGGA 1U32A 5EQVA 3IB8A 3DW8C 3JYFA 3HVQA 4G9JA 4KBPA 4JA7A 3K7VC 4O43A 3DSDA 3N5UA 5GTUA 3H61A 1HO5A 2JOGA 1W24A 1T71A 2HY1A 5JPFA 1USHA 3H68A 1JK7A 3FGAC 5B8IA 2ZBMA 1TCOA 4O4KA 3C9FA 4DSYA 4V0WA 2IE4C 4F0ZA 2ZOAA 4MP0A 1UTEA 4NZVA 1S95A 1WAO1 1UF3A 3THNA 4B2OA 3AUZA 4FCXA 1G5BA 1OIEA 2O8AA 5DNYA 1Z2XA 3CK2A 3TGHA 4DHLA 4H2GA 1S3MA 3RL3A 4IL1A 4H2FA 2ZO9B 4UT3B 2AHDA 4UT2A 4TUGA 3PSOA 2IE3C 2USHA 3FLOA 3IVDA 3GVEA 4IYPC 4MOVA 4LACC 1QFCA 4ZVZA 5HPEA 3H64A 4H2BA 4FBKA 4V0XA 3QFKA 5INBA 4LU9A 3QFMA 2NYLC 5J28A 1S3LA 1Z2WA 3ZU0A 1MF8A 3H67A 2YVTA 1S70A 3T1IA 4FBQA 4YKEA 2WDDA 1S8EA 4FBWA 2XMOA 1FJMA 3KBPA 3E7BA 4I5NC 3D03A 4Q7FA 2CV9A 3H69A 1OIDA 3AV0A 5IOHA 3H60A 4LTYA 3IVEA 3K7WC 2P6BA 2QJCA 2HYPA 5F3WA 4ZX2A 2NXFA 2IAEC 2DXNA 2GJUA 1V73A 2BCDA 1II7A 4WWLA 4ORCA 4ORBA 3QFNA 4TUIA 4ORAA 1S3NA 1T70A 3H63A 1AUIA 2YEQA 4DT2A 2QFPA 4V0VA 5JPEA 4KKZA 1SU1A 4J6OA 3THOB 2Z1AA 3EGHA 4JA9A 3H62B 4H1SA 3PSNA 4H2IA
chains in the Genus database with same CATH topology
3H66A 2Z72A 2NPPC 2WDFA 3QFOA 3C5WC 1WARA 5C1VA 3V4YA 2HYOA 2DXLA 3ZTVA 2Q8UA 4I5LC 4MOYA 1QHWA 2R17A 3P71C 4O24A 2A22A 1XM7A 4UT3A 3DSCA 2WDCA 1XZWA 4OR9A 2Z06A 2WDEA 4UWQA 1M63A 1IT6A 1HP1A 3QG5C 3LL8A 3E7AA 1NNWA 5JJTA 3E0JA 3IB7A 4XPNA 3RQZA 2BDXA 2DFJA 2KKNA 1KBPA 4HD0A 1OI8A 2NYMC 2O8GA 3RL4A 3ICFA 2QFRA 4H1YP 2BQ8X 4O5GA 1HPUA 4M0VA 3RL5A 3EGGA 1U32A 5EQVA 3IB8A 3DW8C 3JYFA 3HVQA 4G9JA 4KBPA 4JA7A 3K7VC 4O43A 3DSDA 3N5UA 5GTUA 3H61A 1HO5A 2JOGA 1W24A 1T71A 2HY1A 5JPFA 1USHA 3H68A 1JK7A 3FGAC 5B8IA 2ZBMA 1TCOA 4O4KA 3C9FA 4DSYA 4V0WA 2IE4C 4F0ZA 2ZOAA 4MP0A 1UTEA 4NZVA 1S95A 1WAO1 1UF3A 3THNA 4B2OA 3AUZA 4FCXA 1G5BA 1OIEA 2O8AA 5DNYA 1Z2XA 3CK2A 3TGHA 4DHLA 4H2GA 1S3MA 3RL3A 4IL1A 4H2FA 2ZO9B 4UT3B 2AHDA 4UT2A 4TUGA 3PSOA 2IE3C 2USHA 3FLOA 3IVDA 3GVEA 4IYPC 4MOVA 4LACC 1QFCA 4ZVZA 5HPEA 3H64A 4H2BA 4FBKA 4V0XA 3QFKA 5INBA 4LU9A 3QFMA 2NYLC 5J28A 1S3LA 1Z2WA 3ZU0A 1MF8A 3H67A 2YVTA 1S70A 3T1IA 4FBQA 4YKEA 2WDDA 1S8EA 4FBWA 2XMOA 1FJMA 3KBPA 3E7BA 4I5NC 3D03A 4Q7FA 2CV9A 3H69A 1OIDA 3AV0A 5IOHA 3H60A 4LTYA 3IVEA 3K7WC 2P6BA 2QJCA 2HYPA 5F3WA 4ZX2A 2NXFA 2IAEC 2DXNA 2GJUA 1V73A 2BCDA 1II7A 4WWLA 4ORCA 4ORBA 3QFNA 4TUIA 4ORAA 1S3NA 1T70A 3H63A 1AUIA 2YEQA 4DT2A 2QFPA 4V0VA 5JPEA 4KKZA 1SU1A 4J6OA 3THOB 2Z1AA 3EGHA 4JA9A 3H62B 4H1SA 3PSNA 4H2IA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3H66 A;  2Z72 A;  2NPP C;  2WDF A;  3QFO A;  3C5W C;  1WAR A;  5C1V A;  3V4Y A;  2HYO A;  3ZTV A;  2Q8U A;  4I5L C;  4MOY A;  1QHW A;  2R17 A;  3P71 C;  4O24 A;  2A22 A;  1XM7 A;  4UT3 A;  3DSC A;  2WDC A;  1XZW A;  4OR9 A;  2Z06 A;  2WDE A;  4UWQ A;  1M63 A;  1IT6 A;  1HP1 A;  3QG5 C;  3LL8 A;  3E7A A;  1NNW A;  5JJT A;  3IB7 A;  4XPN A;  3RQZ A;  2BDX A;  2DFJ A;  2KKN A;  1KBP A;  4HD0 A;  1OI8 A;  2NYM C;  2O8G A;  3RL4 A;  3ICF A;  2QFR A;  4H1Y P;  2BQ8 X;  4O5G A;  1HPU A;  4M0V A;  3RL5 A;  3EGG A;  1U32 A;  5EQV A;  3IB8 A;  3DW8 C;  3JYF A;  3HVQ A;  4G9J A;  4KBP A;  4JA7 A;  3K7V C;  4O43 A;  3DSD A;  3N5U A;  5GTU A;  3H61 A;  1HO5 A;  2JOG A;  1W24 A;  1T71 A;  2HY1 A;  5JPF A;  1USH A;  3H68 A;  1JK7 A;  3FGA C;  5B8I A;  2ZBM A;  1TCO A;  4O4K A;  3C9F A;  4DSY A;  4V0W A;  2IE4 C;  4F0Z A;  4MP0 A;  1UTE A;  4NZV A;  1S95 A;  1WAO 1;  1UF3 A;  3THN A;  4B2O A;  3AUZ A;  4FCX A;  1G5B A;  1OIE A;  2O8A A;  5DNY A;  1Z2X A;  3CK2 A;  3TGH A;  4DHL A;  4H2G A;  1S3M A;  3RL3 A;  4IL1 A;  4H2F A;  4UT3 B;  2AHD A;  4UT2 A;  4TUG A;  3PSO A;  2IE3 C;  2USH A;  3IVD A;  3GVE A;  4IYP C;  4MOV A;  4LAC C;  1QFC A;  4ZVZ A;  5HPE A;  3H64 A;  4H2B A;  4FBK A;  4V0X A;  3QFK A;  5INB A;  4LU9 A;  3QFM A;  2NYL C;  5J28 A;  1S3L A;  1Z2W A;  3ZU0 A;  1MF8 A;  3H67 A;  2YVT A;  1S70 A;  3T1I A;  4FBQ A;  4YKE A;  2WDD A;  1S8E A;  4FBW A;  2XMO A;  1FJM A;  3KBP A;  3E7B A;  4I5N C;  4Q7F A;  5IOH A;  2CV9 A;  3H69 A;  1OID A;  3AV0 A;  3H60 A;  4LTY A;  3IVE A;  3K7W C;  2P6B A;  2QJC A;  2HYP A;  5F3W A;  4ZX2 A;  2NXF A;  2IAE C;  2GJU A;  4WWL A;  1V73 A;  2BCD A;  1II7 A;  4ORC A;  4ORB A;  3QFN A;  4TUI A;  4ORA A;  1S3N A;  1T70 A;  3H63 A;  1AUI A;  4DT2 A;  2QFP A;  4V0V A;  5JPE A;  4KKZ A;  1SU1 A;  4J6O A;  3THO B;  2Z1A A;  3EGH A;  4JA9 A;  3H62 B;  4H1S A;  3PSN A;  4H2I A; 
#chains in the Genus database with same CATH topology
 3H66 A;  2Z72 A;  2NPP C;  2WDF A;  3QFO A;  3C5W C;  1WAR A;  5C1V A;  3V4Y A;  2HYO A;  2DXL A;  3ZTV A;  2Q8U A;  4I5L C;  4MOY A;  1QHW A;  2R17 A;  3P71 C;  4O24 A;  2A22 A;  1XM7 A;  4UT3 A;  3DSC A;  2WDC A;  1XZW A;  4OR9 A;  2Z06 A;  2WDE A;  4UWQ A;  1M63 A;  1IT6 A;  1HP1 A;  3QG5 C;  3LL8 A;  3E7A A;  1NNW A;  5JJT A;  3E0J A;  3IB7 A;  4XPN A;  3RQZ A;  2BDX A;  2DFJ A;  2KKN A;  1KBP A;  4HD0 A;  1OI8 A;  2NYM C;  2O8G A;  3RL4 A;  3ICF A;  2QFR A;  4H1Y P;  2BQ8 X;  4O5G A;  1HPU A;  4M0V A;  3RL5 A;  3EGG A;  1U32 A;  5EQV A;  3IB8 A;  3DW8 C;  3JYF A;  3HVQ A;  4G9J A;  4KBP A;  4JA7 A;  3K7V C;  4O43 A;  3DSD A;  3N5U A;  5GTU A;  3H61 A;  1HO5 A;  2JOG A;  1W24 A;  1T71 A;  2HY1 A;  5JPF A;  1USH A;  3H68 A;  1JK7 A;  3FGA C;  5B8I A;  2ZBM A;  1TCO A;  4O4K A;  3C9F A;  4DSY A;  4V0W A;  2IE4 C;  4F0Z A;  2ZOA A;  4MP0 A;  1UTE A;  4NZV A;  1S95 A;  1WAO 1;  1UF3 A;  3THN A;  4B2O A;  3AUZ A;  4FCX A;  1G5B A;  1OIE A;  2O8A A;  5DNY A;  1Z2X A;  3CK2 A;  3TGH A;  4DHL A;  4H2G A;  1S3M A;  3RL3 A;  4IL1 A;  4H2F A;  2ZO9 B;  4UT3 B;  2AHD A;  4UT2 A;  4TUG A;  3PSO A;  2IE3 C;  2USH A;  3FLO A;  3IVD A;  3GVE A;  4IYP C;  4MOV A;  4LAC C;  1QFC A;  4ZVZ A;  5HPE A;  3H64 A;  4H2B A;  4FBK A;  4V0X A;  3QFK A;  5INB A;  4LU9 A;  3QFM A;  2NYL C;  5J28 A;  1S3L A;  1Z2W A;  3ZU0 A;  1MF8 A;  3H67 A;  2YVT A;  1S70 A;  3T1I A;  4FBQ A;  4YKE A;  2WDD A;  1S8E A;  4FBW A;  2XMO A;  1FJM A;  3KBP A;  3E7B A;  4I5N C;  3D03 A;  4Q7F A;  2CV9 A;  3H69 A;  1OID A;  3AV0 A;  5IOH A;  3H60 A;  4LTY A;  3IVE A;  3K7W C;  2P6B A;  2QJC A;  2HYP A;  5F3W A;  4ZX2 A;  2NXF A;  2IAE C;  2DXN A;  2GJU A;  1V73 A;  2BCD A;  1II7 A;  4WWL A;  4ORC A;  4ORB A;  3QFN A;  4TUI A;  4ORA A;  1S3N A;  1T70 A;  3H63 A;  1AUI A;  2YEQ A;  4DT2 A;  2QFP A;  4V0V A;  5JPE A;  4KKZ A;  1SU1 A;  4J6O A;  3THO B;  2Z1A A;  3EGH A;  4JA9 A;  3H62 B;  4H1S A;  3PSN A;  4H2I A; 
#chains in the Genus database with same CATH homology
 3H66 A;  2Z72 A;  2NPP C;  2WDF A;  3QFO A;  3C5W C;  1WAR A;  5C1V A;  3V4Y A;  2HYO A;  2DXL A;  3ZTV A;  2Q8U A;  4I5L C;  4MOY A;  1QHW A;  2R17 A;  3P71 C;  4O24 A;  2A22 A;  1XM7 A;  4UT3 A;  3DSC A;  2WDC A;  1XZW A;  4OR9 A;  2Z06 A;  2WDE A;  4UWQ A;  1M63 A;  1IT6 A;  1HP1 A;  3QG5 C;  3LL8 A;  3E7A A;  1NNW A;  5JJT A;  3E0J A;  3IB7 A;  4XPN A;  3RQZ A;  2BDX A;  2DFJ A;  2KKN A;  1KBP A;  4HD0 A;  1OI8 A;  2NYM C;  2O8G A;  3RL4 A;  3ICF A;  2QFR A;  4H1Y P;  2BQ8 X;  4O5G A;  1HPU A;  4M0V A;  3RL5 A;  3EGG A;  1U32 A;  5EQV A;  3IB8 A;  3DW8 C;  3JYF A;  3HVQ A;  4G9J A;  4KBP A;  4JA7 A;  3K7V C;  4O43 A;  3DSD A;  3N5U A;  5GTU A;  3H61 A;  1HO5 A;  2JOG A;  1W24 A;  1T71 A;  2HY1 A;  5JPF A;  1USH A;  3H68 A;  1JK7 A;  3FGA C;  5B8I A;  2ZBM A;  1TCO A;  4O4K A;  3C9F A;  4DSY A;  4V0W A;  2IE4 C;  4F0Z A;  2ZOA A;  4MP0 A;  1UTE A;  4NZV A;  1S95 A;  1WAO 1;  1UF3 A;  3THN A;  4B2O A;  3AUZ A;  4FCX A;  1G5B A;  1OIE A;  2O8A A;  5DNY A;  1Z2X A;  3CK2 A;  3TGH A;  4DHL A;  4H2G A;  1S3M A;  3RL3 A;  4IL1 A;  4H2F A;  2ZO9 B;  4UT3 B;  2AHD A;  4UT2 A;  4TUG A;  3PSO A;  2IE3 C;  2USH A;  3FLO A;  3IVD A;  3GVE A;  4IYP C;  4MOV A;  4LAC C;  1QFC A;  4ZVZ A;  5HPE A;  3H64 A;  4H2B A;  4FBK A;  4V0X A;  3QFK A;  5INB A;  4LU9 A;  3QFM A;  2NYL C;  5J28 A;  1S3L A;  1Z2W A;  3ZU0 A;  1MF8 A;  3H67 A;  2YVT A;  1S70 A;  3T1I A;  4FBQ A;  4YKE A;  2WDD A;  1S8E A;  4FBW A;  2XMO A;  1FJM A;  3KBP A;  3E7B A;  4I5N C;  3D03 A;  4Q7F A;  2CV9 A;  3H69 A;  1OID A;  3AV0 A;  5IOH A;  3H60 A;  4LTY A;  3IVE A;  3K7W C;  2P6B A;  2QJC A;  2HYP A;  5F3W A;  4ZX2 A;  2NXF A;  2IAE C;  2DXN A;  2GJU A;  1V73 A;  2BCD A;  1II7 A;  4WWL A;  4ORC A;  4ORB A;  3QFN A;  4TUI A;  4ORA A;  1S3N A;  1T70 A;  3H63 A;  1AUI A;  2YEQ A;  4DT2 A;  2QFP A;  4V0V A;  5JPE A;  4KKZ A;  1SU1 A;  4J6O A;  3THO B;  2Z1A A;  3EGH A;  4JA9 A;  3H62 B;  4H1S A;  3PSN A;  4H2I A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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