4H2GA

Human ecto-5'-nucleotidase (cd73): crystal form ii (open) in complex with adenosine
Total Genus 184
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
184
sequence length
524
structure length
524
Chain Sequence
PWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHADEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTACAVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords 5'-nucleotidase
publication title Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling.
pubmed doi rcsb
source organism Homo sapiens
total genus 184
structure length 524
sequence length 524
ec nomenclature ec 3.1.3.5: 5'-nucleotidase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF02872 5_nucleotid_C 5'-nucleotidase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4h2gA01
3.90.780.10 Alpha Beta Alpha-Beta Complex 5'-nucleotidase; domain 2 5'-Nucleotidase, C-terminal domain 4h2gA02
2NPPC 3DSCA 4UT3B 5GTUA 1OIDA 2P6BA 1S8EA 4TUGA 4O24A 2BDXA 3V4YA 4H1SA 4G9JA 2USHA 2AHDA 3RL4A 4FCXA 5EQVA 5B8IA 4FBQA 1S3LA 3QG5C 4V0VA 5IOHA 4FBWA 2JOGA 3AUZA 3LL8A 5DNYA 3H64A 3ZTVA 3H60A 2DFJA 1V73A 1S3NA 3CK2A 3H62B 2WDFA 2ZBMA 4IL1A 2IE3C 3P71C 3JYFA 4YKEA 3N5UA 1WARA 1HP1A 1II7A 4MP0A 3H67A 4JA9A 1M63A 4H2FA 3K7VC 4FBKA 1MF8A 4NZVA 5J28A 4TUIA 1USHA 4H2BA 3K7WC 2WDDA 2XMOA 2YVTA 4XPNA 4J6OA 4O5GA 3FGAC 3QFMA 3E7BA 4WWLA 1T70A 1S70A 1UF3A 2Q8UA 3C5WC 4ORAA 4MOVA 1T71A 2GJUA 1S3MA 4UT2A 1NNWA 3PSOA 4HD0A 4O43A 4DT2A 4H1YP 4OR9A 1QFCA 1KBPA 4UT3A 1W24A 2HYPA 2BQ8X 2A22A 2CV9A 1Z2WA 3C9FA 4KBPA 5HPEA 1S95A 5F3WA 3H63A 4I5LC 4B2OA 3KBPA 4IYPC 1HO5A 3TGHA 4ORCA 4LU9A 3H68A 4ORBA 1AUIA 1OI8A 3PSNA 2HY1A 1HPUA 3H61A 3QFNA 3DW8C 1QHWA 4F0ZA 2BCDA 3QFKA 1XZWA 1JK7A 4UWQA 4KKZA 4DHLA 3HVQA 1IT6A 2QJCA 3H66A 1SU1A 1U32A 2QFRA 2WDEA 4H2IA 4V0XA 3EGHA 4DSYA 4ZVZA 4MOYA 5JPEA 3IB8A 4O4KA 2Z06A 4LACC 2NXFA 1TCOA 3AV0A 1XM7A 3GVEA 3IVEA 4M0VA 2Z72A 3EGGA 4V0WA 2IE4C 2WDCA 4H2GA 3QFOA 3IVDA 1Z2XA 2Z1AA 4LTYA 5JPFA 3ZU0A 5C1VA 1WAO1 4I5NC 1G5BA 2QFPA 3E7AA 4Q7FA 1UTEA 3ICFA 3THNA 3THOB 3RQZA 3H69A 5JJTA 2O8AA 2NYMC 2R17A 3RL5A 2KKNA 5INBA 2HYOA 4JA7A 3T1IA 3DSDA 2O8GA 3IB7A 3RL3A 2IAEC 1OIEA 1FJMA 2NYLC 4ZX2A
chains in the Genus database with same CATH superfamily
2NPPC 3DSCA 4UT3B 5GTUA 1OIDA 2P6BA 1S8EA 4TUGA 4O24A 2BDXA 3V4YA 4H1SA 4G9JA 2USHA 2AHDA 3RL4A 4FCXA 5EQVA 5B8IA 4FBQA 1S3LA 2ZOAA 3QG5C 4V0VA 5IOHA 4FBWA 2JOGA 3AUZA 3LL8A 5DNYA 3H64A 3ZTVA 2DXNA 3H60A 2DFJA 1V73A 1S3NA 3CK2A 3H62B 2WDFA 2ZBMA 4IL1A 2IE3C 3P71C 3JYFA 4YKEA 3N5UA 1WARA 1HP1A 1II7A 4MP0A 3H67A 4JA9A 1M63A 4H2FA 3K7VC 4FBKA 1MF8A 4NZVA 5J28A 4TUIA 1USHA 4H2BA 3K7WC 2WDDA 2XMOA 2YVTA 4XPNA 4J6OA 4O5GA 3FGAC 3FLOA 3QFMA 3E7BA 4WWLA 3D03A 1T70A 1S70A 1UF3A 2Q8UA 3C5WC 4ORAA 4MOVA 1T71A 2GJUA 1S3MA 4UT2A 1NNWA 3PSOA 4HD0A 4O43A 4DT2A 4H1YP 4OR9A 1QFCA 1KBPA 4UT3A 1W24A 2HYPA 2BQ8X 2A22A 2CV9A 1Z2WA 3C9FA 4KBPA 5HPEA 2ZO9B 1S95A 5F3WA 3H63A 4I5LC 4B2OA 3KBPA 4IYPC 1HO5A 3TGHA 4ORCA 4LU9A 3H68A 4ORBA 2YEQA 1AUIA 1OI8A 3PSNA 2HY1A 1HPUA 3H61A 3QFNA 3DW8C 1QHWA 4F0ZA 2BCDA 3QFKA 1XZWA 1JK7A 4UWQA 4KKZA 4DHLA 3HVQA 1IT6A 2QJCA 3H66A 1SU1A 1U32A 2QFRA 2WDEA 4H2IA 4V0XA 3EGHA 4DSYA 4ZVZA 4MOYA 5JPEA 3IB8A 4O4KA 2Z06A 4LACC 2NXFA 1TCOA 3AV0A 1XM7A 3GVEA 3IVEA 4M0VA 2Z72A 3EGGA 4V0WA 2IE4C 2WDCA 4H2GA 3QFOA 3IVDA 1Z2XA 2Z1AA 4LTYA 5JPFA 3ZU0A 5C1VA 1WAO1 4I5NC 1G5BA 2QFPA 3E7AA 4Q7FA 1UTEA 3ICFA 3THNA 3THOB 3RQZA 3H69A 2DXLA 5JJTA 2O8AA 2NYMC 2R17A 3RL5A 2KKNA 5INBA 2HYOA 4JA7A 3T1IA 3DSDA 2O8GA 3IB7A 3RL3A 2IAEC 1OIEA 1FJMA 3E0JA 2NYLC 4ZX2A
chains in the Genus database with same CATH topology
2NPPC 3DSCA 4UT3B 5GTUA 1OIDA 2P6BA 1S8EA 4TUGA 4O24A 2BDXA 3V4YA 4H1SA 4G9JA 2USHA 2AHDA 3RL4A 4FCXA 5EQVA 5B8IA 4FBQA 1S3LA 2ZOAA 3QG5C 4V0VA 5IOHA 4FBWA 2JOGA 3AUZA 3LL8A 5DNYA 3H64A 3ZTVA 2DXNA 3H60A 2DFJA 1V73A 1S3NA 3CK2A 3H62B 2WDFA 2ZBMA 4IL1A 2IE3C 3P71C 3JYFA 4YKEA 3N5UA 1WARA 1HP1A 1II7A 4MP0A 3H67A 4JA9A 1M63A 4H2FA 3K7VC 4FBKA 1MF8A 4NZVA 5J28A 4TUIA 1USHA 4H2BA 3K7WC 2WDDA 2XMOA 2YVTA 4XPNA 4J6OA 4O5GA 3FGAC 3FLOA 3QFMA 3E7BA 4WWLA 3D03A 1T70A 1S70A 1UF3A 2Q8UA 3C5WC 4ORAA 4MOVA 1T71A 2GJUA 1S3MA 4UT2A 1NNWA 3PSOA 4HD0A 4O43A 4DT2A 4H1YP 4OR9A 1QFCA 1KBPA 4UT3A 1W24A 2HYPA 2BQ8X 2A22A 2CV9A 1Z2WA 3C9FA 4KBPA 5HPEA 2ZO9B 1S95A 5F3WA 3H63A 4I5LC 4B2OA 3KBPA 4IYPC 1HO5A 3TGHA 4ORCA 4LU9A 3H68A 4ORBA 2YEQA 1AUIA 1OI8A 3PSNA 2HY1A 1HPUA 3H61A 3QFNA 3DW8C 1QHWA 4F0ZA 2BCDA 3QFKA 1XZWA 1JK7A 4UWQA 4KKZA 4DHLA 3HVQA 1IT6A 2QJCA 3H66A 1SU1A 1U32A 2QFRA 2WDEA 4H2IA 4V0XA 3EGHA 4DSYA 4ZVZA 4MOYA 5JPEA 3IB8A 4O4KA 2Z06A 4LACC 2NXFA 1TCOA 3AV0A 1XM7A 3GVEA 3IVEA 4M0VA 2Z72A 3EGGA 4V0WA 2IE4C 2WDCA 4H2GA 3QFOA 3IVDA 1Z2XA 2Z1AA 4LTYA 5JPFA 3ZU0A 5C1VA 1WAO1 4I5NC 1G5BA 2QFPA 3E7AA 4Q7FA 1UTEA 3ICFA 3THNA 3THOB 3RQZA 3H69A 2DXLA 5JJTA 2O8AA 2NYMC 2R17A 3RL5A 2KKNA 5INBA 2HYOA 4JA7A 3T1IA 3DSDA 2O8GA 3IB7A 3RL3A 2IAEC 1OIEA 1FJMA 3E0JA 2NYLC 4ZX2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NPP C;  3DSC A;  4UT3 B;  5GTU A;  1OID A;  2P6B A;  1S8E A;  4TUG A;  4O24 A;  2BDX A;  3V4Y A;  4H1S A;  4G9J A;  2USH A;  2AHD A;  3RL4 A;  4FCX A;  5EQV A;  5B8I A;  4FBQ A;  1S3L A;  3QG5 C;  4V0V A;  5IOH A;  4FBW A;  2JOG A;  3AUZ A;  3LL8 A;  5DNY A;  3H64 A;  3ZTV A;  3H60 A;  2DFJ A;  1V73 A;  1S3N A;  3CK2 A;  3H62 B;  2WDF A;  2ZBM A;  4IL1 A;  2IE3 C;  3P71 C;  3JYF A;  4YKE A;  3N5U A;  1WAR A;  1HP1 A;  1II7 A;  4MP0 A;  3H67 A;  4JA9 A;  1M63 A;  4H2F A;  3K7V C;  4FBK A;  1MF8 A;  4NZV A;  5J28 A;  4TUI A;  1USH A;  4H2B A;  3K7W C;  2WDD A;  2XMO A;  2YVT A;  4XPN A;  4J6O A;  4O5G A;  3FGA C;  3QFM A;  3E7B A;  4WWL A;  1T70 A;  1S70 A;  1UF3 A;  2Q8U A;  3C5W C;  4ORA A;  4MOV A;  1T71 A;  2GJU A;  1S3M A;  4UT2 A;  1NNW A;  3PSO A;  4HD0 A;  4O43 A;  4DT2 A;  4H1Y P;  4OR9 A;  1QFC A;  1KBP A;  4UT3 A;  1W24 A;  2HYP A;  2BQ8 X;  2A22 A;  2CV9 A;  1Z2W A;  3C9F A;  4KBP A;  5HPE A;  1S95 A;  5F3W A;  3H63 A;  4I5L C;  4B2O A;  3KBP A;  4IYP C;  1HO5 A;  3TGH A;  4ORC A;  4LU9 A;  3H68 A;  4ORB A;  1AUI A;  1OI8 A;  3PSN A;  2HY1 A;  1HPU A;  3H61 A;  3QFN A;  3DW8 C;  1QHW A;  4F0Z A;  2BCD A;  3QFK A;  1XZW A;  1JK7 A;  4UWQ A;  4KKZ A;  4DHL A;  3HVQ A;  1IT6 A;  2QJC A;  3H66 A;  1SU1 A;  1U32 A;  2QFR A;  2WDE A;  4H2I A;  4V0X A;  3EGH A;  4DSY A;  4ZVZ A;  4MOY A;  5JPE A;  3IB8 A;  4O4K A;  2Z06 A;  4LAC C;  2NXF A;  1TCO A;  3AV0 A;  1XM7 A;  3GVE A;  3IVE A;  4M0V A;  2Z72 A;  3EGG A;  4V0W A;  2IE4 C;  2WDC A;  4H2G A;  3QFO A;  3IVD A;  1Z2X A;  2Z1A A;  4LTY A;  5JPF A;  3ZU0 A;  5C1V A;  1WAO 1;  4I5N C;  1G5B A;  2QFP A;  3E7A A;  4Q7F A;  1UTE A;  3ICF A;  3THN A;  3THO B;  3RQZ A;  3H69 A;  5JJT A;  2O8A A;  2NYM C;  2R17 A;  3RL5 A;  2KKN A;  5INB A;  2HYO A;  4JA7 A;  3T1I A;  3DSD A;  2O8G A;  3IB7 A;  3RL3 A;  2IAE C;  1OIE A;  1FJM A;  2NYL C;  4ZX2 A; 
#chains in the Genus database with same CATH topology
 2NPP C;  3DSC A;  4UT3 B;  5GTU A;  1OID A;  2P6B A;  1S8E A;  4TUG A;  4O24 A;  2BDX A;  3V4Y A;  4H1S A;  4G9J A;  2USH A;  2AHD A;  3RL4 A;  4FCX A;  5EQV A;  5B8I A;  4FBQ A;  1S3L A;  2ZOA A;  3QG5 C;  4V0V A;  5IOH A;  4FBW A;  2JOG A;  3AUZ A;  3LL8 A;  5DNY A;  3H64 A;  3ZTV A;  2DXN A;  3H60 A;  2DFJ A;  1V73 A;  1S3N A;  3CK2 A;  3H62 B;  2WDF A;  2ZBM A;  4IL1 A;  2IE3 C;  3P71 C;  3JYF A;  4YKE A;  3N5U A;  1WAR A;  1HP1 A;  1II7 A;  4MP0 A;  3H67 A;  4JA9 A;  1M63 A;  4H2F A;  3K7V C;  4FBK A;  1MF8 A;  4NZV A;  5J28 A;  4TUI A;  1USH A;  4H2B A;  3K7W C;  2WDD A;  2XMO A;  2YVT A;  4XPN A;  4J6O A;  4O5G A;  3FGA C;  3FLO A;  3QFM A;  3E7B A;  4WWL A;  3D03 A;  1T70 A;  1S70 A;  1UF3 A;  2Q8U A;  3C5W C;  4ORA A;  4MOV A;  1T71 A;  2GJU A;  1S3M A;  4UT2 A;  1NNW A;  3PSO A;  4HD0 A;  4O43 A;  4DT2 A;  4H1Y P;  4OR9 A;  1QFC A;  1KBP A;  4UT3 A;  1W24 A;  2HYP A;  2BQ8 X;  2A22 A;  2CV9 A;  1Z2W A;  3C9F A;  4KBP A;  5HPE A;  2ZO9 B;  1S95 A;  5F3W A;  3H63 A;  4I5L C;  4B2O A;  3KBP A;  4IYP C;  1HO5 A;  3TGH A;  4ORC A;  4LU9 A;  3H68 A;  4ORB A;  2YEQ A;  1AUI A;  1OI8 A;  3PSN A;  2HY1 A;  1HPU A;  3H61 A;  3QFN A;  3DW8 C;  1QHW A;  4F0Z A;  2BCD A;  3QFK A;  1XZW A;  1JK7 A;  4UWQ A;  4KKZ A;  4DHL A;  3HVQ A;  1IT6 A;  2QJC A;  3H66 A;  1SU1 A;  1U32 A;  2QFR A;  2WDE A;  4H2I A;  4V0X A;  3EGH A;  4DSY A;  4ZVZ A;  4MOY A;  5JPE A;  3IB8 A;  4O4K A;  2Z06 A;  4LAC C;  2NXF A;  1TCO A;  3AV0 A;  1XM7 A;  3GVE A;  3IVE A;  4M0V A;  2Z72 A;  3EGG A;  4V0W A;  2IE4 C;  2WDC A;  4H2G A;  3QFO A;  3IVD A;  1Z2X A;  2Z1A A;  4LTY A;  5JPF A;  3ZU0 A;  5C1V A;  1WAO 1;  4I5N C;  1G5B A;  2QFP A;  3E7A A;  4Q7F A;  1UTE A;  3ICF A;  3THN A;  3THO B;  3RQZ A;  3H69 A;  2DXL A;  5JJT A;  2O8A A;  2NYM C;  2R17 A;  3RL5 A;  2KKN A;  5INB A;  2HYO A;  4JA7 A;  3T1I A;  3DSD A;  2O8G A;  3IB7 A;  3RL3 A;  2IAE C;  1OIE A;  1FJM A;  3E0J A;  2NYL C;  4ZX2 A; 
#chains in the Genus database with same CATH homology
 2NPP C;  3DSC A;  4UT3 B;  5GTU A;  1OID A;  2P6B A;  1S8E A;  4TUG A;  4O24 A;  2BDX A;  3V4Y A;  4H1S A;  4G9J A;  2USH A;  2AHD A;  3RL4 A;  4FCX A;  5EQV A;  5B8I A;  4FBQ A;  1S3L A;  2ZOA A;  3QG5 C;  4V0V A;  5IOH A;  4FBW A;  2JOG A;  3AUZ A;  3LL8 A;  5DNY A;  3H64 A;  3ZTV A;  2DXN A;  3H60 A;  2DFJ A;  1V73 A;  1S3N A;  3CK2 A;  3H62 B;  2WDF A;  2ZBM A;  4IL1 A;  2IE3 C;  3P71 C;  3JYF A;  4YKE A;  3N5U A;  1WAR A;  1HP1 A;  1II7 A;  4MP0 A;  3H67 A;  4JA9 A;  1M63 A;  4H2F A;  3K7V C;  4FBK A;  1MF8 A;  4NZV A;  5J28 A;  4TUI A;  1USH A;  4H2B A;  3K7W C;  2WDD A;  2XMO A;  2YVT A;  4XPN A;  4J6O A;  4O5G A;  3FGA C;  3FLO A;  3QFM A;  3E7B A;  4WWL A;  3D03 A;  1T70 A;  1S70 A;  1UF3 A;  2Q8U A;  3C5W C;  4ORA A;  4MOV A;  1T71 A;  2GJU A;  1S3M A;  4UT2 A;  1NNW A;  3PSO A;  4HD0 A;  4O43 A;  4DT2 A;  4H1Y P;  4OR9 A;  1QFC A;  1KBP A;  4UT3 A;  1W24 A;  2HYP A;  2BQ8 X;  2A22 A;  2CV9 A;  1Z2W A;  3C9F A;  4KBP A;  5HPE A;  2ZO9 B;  1S95 A;  5F3W A;  3H63 A;  4I5L C;  4B2O A;  3KBP A;  4IYP C;  1HO5 A;  3TGH A;  4ORC A;  4LU9 A;  3H68 A;  4ORB A;  2YEQ A;  1AUI A;  1OI8 A;  3PSN A;  2HY1 A;  1HPU A;  3H61 A;  3QFN A;  3DW8 C;  1QHW A;  4F0Z A;  2BCD A;  3QFK A;  1XZW A;  1JK7 A;  4UWQ A;  4KKZ A;  4DHL A;  3HVQ A;  1IT6 A;  2QJC A;  3H66 A;  1SU1 A;  1U32 A;  2QFR A;  2WDE A;  4H2I A;  4V0X A;  3EGH A;  4DSY A;  4ZVZ A;  4MOY A;  5JPE A;  3IB8 A;  4O4K A;  2Z06 A;  4LAC C;  2NXF A;  1TCO A;  3AV0 A;  1XM7 A;  3GVE A;  3IVE A;  4M0V A;  2Z72 A;  3EGG A;  4V0W A;  2IE4 C;  2WDC A;  4H2G A;  3QFO A;  3IVD A;  1Z2X A;  2Z1A A;  4LTY A;  5JPF A;  3ZU0 A;  5C1V A;  1WAO 1;  4I5N C;  1G5B A;  2QFP A;  3E7A A;  4Q7F A;  1UTE A;  3ICF A;  3THN A;  3THO B;  3RQZ A;  3H69 A;  2DXL A;  5JJT A;  2O8A A;  2NYM C;  2R17 A;  3RL5 A;  2KKN A;  5INB A;  2HYO A;  4JA7 A;  3T1I A;  3DSD A;  2O8G A;  3IB7 A;  3RL3 A;  2IAE C;  1OIE A;  1FJM A;  3E0J A;  2NYL C;  4ZX2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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