4H2GA

Human ecto-5'-nucleotidase (cd73): crystal form ii (open) in complex with adenosine
Total Genus 184
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
184
sequence length
524
structure length
524
Chain Sequence
PWELTILHTNDVHSRLEQTSEDSSKCVDASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLDSSIPEDPSIKADINKWRIKLDDYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHADEMFWNHVSMCILNGGGIRSPIDERNDGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTACAVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords 5'-nucleotidase
total genus 184
structure length 524
sequence length 524
ec nomenclature ec 3.1.3.5: 5'-nucleotidase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
A PF02872 5_nucleotid_C 5'-nucleotidase, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 4h2gA01
3.90.780.10 Alpha Beta Alpha-Beta Complex 5'-nucleotidase; domain 2 5'-Nucleotidase, C-terminal domain 4h2gA02
3DW8C 3EGGA 4V0XA 1XZWA 4DSYA 3CK2A 5B8IA 1U32A 2BDXA 1S95A 1MF8A 3N5UA 1W24A 4I5NC 3LL8A 3IVEA 3E7AA 3QFNA 1FJMA 2ZBMA 2WDDA 2IE4C 2WDCA 3PSOA 2HYOA 4WWLA 4UWQA 3QFKA 1SU1A 1S3LA 2NXFA 4V0VA 2JOGA 4FCXA 1UTEA 4MOYA 1KBPA 4NZVA 3H60A 4B2OA 3QG5C 3H68A 3K7WC 2CV9A 3DSCA 1QHWA 1M63A 1HO5A 4ZX2A 4M0VA 3THNA 2BQ8X 5EQVA 5F3WA 2NYMC 1OIEA 2Z1AA 3H62B 1S70A 3C5WC 3P71C 4LU9A 2WDEA 2O8AA 3H61A 1S3NA 2IAEC 3H66A 2HY1A 3QFOA 1AUIA 3H64A 3ICFA 5GTUA 4JA9A 5C1VA 4KBPA 3T1IA 4DHLA 4XPNA 2P6BA 1HPUA 3IVDA 2XMOA 3QFMA 3V4YA 4ORAA 4LACC 3HVQA 2R17A 3E7BA 4J6OA 3KBPA 3EGHA 5J28A 4I5LC 1T71A 1JK7A 2KKNA 4H1SA 3ZU0A 4FBKA 4FBQA 2A22A 4UT3B 2QFRA 2NYLC 4UT2A 4ORBA 5JJTA 4UT3A 4H2GA 3PSNA 3DSDA 4TUGA 1OIDA 1II7A 1T70A 2QFPA 2QJCA 2WDFA 2Q8UA 2BCDA 3FGAC 3JYFA 5HPEA 4H2FA 1WARA 1NNWA 1S3MA 1V73A 4MOVA 2DFJA 1IT6A 2GJUA 4ORCA 3ZTVA 4O24A 1QFCA 3RL3A 2HYPA 1G5BA 3H67A 1OI8A 3IB8A 4O5GA 3RL4A 1Z2XA 3C9FA 4Q7FA 4IYPC 1S8EA 1WAO1 4DT2A 5DNYA 3H69A 4V0WA 3H63A 4JA7A 4MP0A 1UF3A 2Z06A 5JPEA 4H2BA 3K7VC 3TGHA 4G9JA 1TCOA 2NPPC 5INBA 2USHA 2O8GA 1Z2WA 4H2IA 3RL5A 3AUZA 4O4KA 3THOB 5IOHA 4TUIA 5JPFA 4IL1A 2YVTA 4OR9A 4HD0A 3AV0A 1XM7A 4ZVZA 4LTYA 4O43A 4H1YP 4YKEA 2IE3C 3RQZA 2AHDA 4FBWA 4KKZA 1HP1A 2Z72A 3GVEA 4F0ZA 1USHA 3IB7A
chains in the Genus database with same CATH superfamily
3DW8C 3EGGA 4V0XA 1XZWA 4DSYA 3CK2A 5B8IA 1U32A 2BDXA 1S95A 1MF8A 3N5UA 1W24A 4I5NC 3LL8A 3IVEA 3E7AA 3QFNA 1FJMA 2ZBMA 2WDDA 2IE4C 2WDCA 3PSOA 2HYOA 4WWLA 4UWQA 3QFKA 1SU1A 1S3LA 2NXFA 4V0VA 2JOGA 4FCXA 3FLOA 1UTEA 4MOYA 1KBPA 4NZVA 3D03A 3H60A 4B2OA 3QG5C 3H68A 3K7WC 2CV9A 3DSCA 1QHWA 1M63A 1HO5A 4ZX2A 4M0VA 3THNA 2BQ8X 5EQVA 5F3WA 2NYMC 1OIEA 2Z1AA 3H62B 1S70A 3C5WC 3P71C 4LU9A 2WDEA 2O8AA 3H61A 1S3NA 2DXNA 2IAEC 3H66A 2HY1A 3QFOA 1AUIA 3H64A 3ICFA 5GTUA 4JA9A 5C1VA 4KBPA 3E0JA 3T1IA 4DHLA 4XPNA 2P6BA 1HPUA 3IVDA 2XMOA 3QFMA 2YEQA 3V4YA 4ORAA 4LACC 3HVQA 2R17A 3E7BA 4J6OA 3KBPA 3EGHA 5J28A 4I5LC 1T71A 1JK7A 2KKNA 4H1SA 3ZU0A 4FBKA 4FBQA 2A22A 4UT3B 2QFRA 2NYLC 4UT2A 4ORBA 5JJTA 4UT3A 4H2GA 3PSNA 3DSDA 4TUGA 1OIDA 1II7A 2QFPA 1T70A 2QJCA 2WDFA 2Q8UA 2BCDA 3FGAC 3JYFA 5HPEA 4H2FA 1WARA 1NNWA 1S3MA 1V73A 4MOVA 2DFJA 1IT6A 2GJUA 2DXLA 4ORCA 3ZTVA 4O24A 1QFCA 3RL3A 2HYPA 1G5BA 3H67A 1OI8A 3IB8A 4O5GA 3RL4A 1Z2XA 3C9FA 4Q7FA 4IYPC 1S8EA 1WAO1 4DT2A 5DNYA 3H69A 4V0WA 3H63A 4JA7A 4MP0A 1UF3A 2ZOAA 2Z06A 5JPEA 4H2BA 3K7VC 3TGHA 2ZO9B 4G9JA 1TCOA 2NPPC 5INBA 2USHA 2O8GA 1Z2WA 4H2IA 3RL5A 3AUZA 4O4KA 3THOB 5IOHA 4TUIA 5JPFA 4IL1A 2YVTA 4OR9A 4HD0A 3AV0A 1XM7A 4ZVZA 4LTYA 4O43A 4H1YP 4YKEA 2IE3C 3RQZA 2AHDA 4FBWA 4KKZA 1HP1A 2Z72A 3GVEA 4F0ZA 1USHA 3IB7A
chains in the Genus database with same CATH topology
3DW8C 3EGGA 4V0XA 1XZWA 4DSYA 3CK2A 5B8IA 1U32A 2BDXA 1S95A 1MF8A 3N5UA 1W24A 4I5NC 3LL8A 3IVEA 3E7AA 3QFNA 1FJMA 2ZBMA 2WDDA 2IE4C 2WDCA 3PSOA 2HYOA 4WWLA 4UWQA 3QFKA 1SU1A 1S3LA 2NXFA 4V0VA 2JOGA 4FCXA 3FLOA 1UTEA 4MOYA 1KBPA 4NZVA 3D03A 3H60A 4B2OA 3QG5C 3H68A 3K7WC 2CV9A 3DSCA 1QHWA 1M63A 1HO5A 4ZX2A 4M0VA 3THNA 2BQ8X 5EQVA 5F3WA 2NYMC 1OIEA 2Z1AA 3H62B 1S70A 3C5WC 3P71C 4LU9A 2WDEA 2O8AA 3H61A 1S3NA 2DXNA 2IAEC 3H66A 2HY1A 3QFOA 1AUIA 3H64A 3ICFA 5GTUA 4JA9A 5C1VA 4KBPA 3E0JA 3T1IA 4DHLA 4XPNA 2P6BA 1HPUA 3IVDA 2XMOA 3QFMA 2YEQA 3V4YA 4ORAA 4LACC 3HVQA 2R17A 3E7BA 4J6OA 3KBPA 3EGHA 5J28A 4I5LC 1T71A 1JK7A 2KKNA 4H1SA 3ZU0A 4FBKA 4FBQA 2A22A 4UT3B 2QFRA 2NYLC 4UT2A 4ORBA 5JJTA 4UT3A 4H2GA 3PSNA 3DSDA 4TUGA 1OIDA 1II7A 2QFPA 1T70A 2QJCA 2WDFA 2Q8UA 2BCDA 3FGAC 3JYFA 5HPEA 4H2FA 1WARA 1NNWA 1S3MA 1V73A 4MOVA 2DFJA 1IT6A 2GJUA 2DXLA 4ORCA 3ZTVA 4O24A 1QFCA 3RL3A 2HYPA 1G5BA 3H67A 1OI8A 3IB8A 4O5GA 3RL4A 1Z2XA 3C9FA 4Q7FA 4IYPC 1S8EA 1WAO1 4DT2A 5DNYA 3H69A 4V0WA 3H63A 4JA7A 4MP0A 1UF3A 2ZOAA 2Z06A 5JPEA 4H2BA 3K7VC 3TGHA 2ZO9B 4G9JA 1TCOA 2NPPC 5INBA 2USHA 2O8GA 1Z2WA 4H2IA 3RL5A 3AUZA 4O4KA 3THOB 5IOHA 4TUIA 5JPFA 4IL1A 2YVTA 4OR9A 4HD0A 3AV0A 1XM7A 4ZVZA 4LTYA 4O43A 4H1YP 4YKEA 2IE3C 3RQZA 2AHDA 4FBWA 4KKZA 1HP1A 2Z72A 3GVEA 4F0ZA 1USHA 3IB7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DW8 C;  3EGG A;  4V0X A;  1XZW A;  4DSY A;  3CK2 A;  5B8I A;  1U32 A;  2BDX A;  1S95 A;  1MF8 A;  3N5U A;  1W24 A;  4I5N C;  3LL8 A;  3IVE A;  3E7A A;  3QFN A;  1FJM A;  2ZBM A;  2WDD A;  2IE4 C;  2WDC A;  3PSO A;  2HYO A;  4WWL A;  4UWQ A;  3QFK A;  1SU1 A;  1S3L A;  2NXF A;  4V0V A;  2JOG A;  4FCX A;  1UTE A;  4MOY A;  1KBP A;  4NZV A;  3H60 A;  4B2O A;  3QG5 C;  3H68 A;  3K7W C;  2CV9 A;  3DSC A;  1QHW A;  1M63 A;  1HO5 A;  4ZX2 A;  4M0V A;  3THN A;  2BQ8 X;  5EQV A;  5F3W A;  2NYM C;  1OIE A;  2Z1A A;  3H62 B;  1S70 A;  3C5W C;  3P71 C;  4LU9 A;  2WDE A;  2O8A A;  3H61 A;  1S3N A;  2IAE C;  3H66 A;  2HY1 A;  3QFO A;  1AUI A;  3H64 A;  3ICF A;  5GTU A;  4JA9 A;  5C1V A;  4KBP A;  3T1I A;  4DHL A;  4XPN A;  2P6B A;  1HPU A;  3IVD A;  2XMO A;  3QFM A;  3V4Y A;  4ORA A;  4LAC C;  3HVQ A;  2R17 A;  3E7B A;  4J6O A;  3KBP A;  3EGH A;  5J28 A;  4I5L C;  1T71 A;  1JK7 A;  2KKN A;  4H1S A;  3ZU0 A;  4FBK A;  4FBQ A;  2A22 A;  4UT3 B;  2QFR A;  2NYL C;  4UT2 A;  4ORB A;  5JJT A;  4UT3 A;  4H2G A;  3PSN A;  3DSD A;  4TUG A;  1OID A;  1II7 A;  1T70 A;  2QFP A;  2QJC A;  2WDF A;  2Q8U A;  2BCD A;  3FGA C;  3JYF A;  5HPE A;  4H2F A;  1WAR A;  1NNW A;  1S3M A;  1V73 A;  4MOV A;  2DFJ A;  1IT6 A;  2GJU A;  4ORC A;  3ZTV A;  4O24 A;  1QFC A;  3RL3 A;  2HYP A;  1G5B A;  3H67 A;  1OI8 A;  3IB8 A;  4O5G A;  3RL4 A;  1Z2X A;  3C9F A;  4Q7F A;  4IYP C;  1S8E A;  1WAO 1;  4DT2 A;  5DNY A;  3H69 A;  4V0W A;  3H63 A;  4JA7 A;  4MP0 A;  1UF3 A;  2Z06 A;  5JPE A;  4H2B A;  3K7V C;  3TGH A;  4G9J A;  1TCO A;  2NPP C;  5INB A;  2USH A;  2O8G A;  1Z2W A;  4H2I A;  3RL5 A;  3AUZ A;  4O4K A;  3THO B;  5IOH A;  4TUI A;  5JPF A;  4IL1 A;  2YVT A;  4OR9 A;  4HD0 A;  3AV0 A;  1XM7 A;  4ZVZ A;  4LTY A;  4O43 A;  4H1Y P;  4YKE A;  2IE3 C;  3RQZ A;  2AHD A;  4FBW A;  4KKZ A;  1HP1 A;  2Z72 A;  3GVE A;  4F0Z A;  1USH A;  3IB7 A; 
#chains in the Genus database with same CATH topology
 3DW8 C;  3EGG A;  4V0X A;  1XZW A;  4DSY A;  3CK2 A;  5B8I A;  1U32 A;  2BDX A;  1S95 A;  1MF8 A;  3N5U A;  1W24 A;  4I5N C;  3LL8 A;  3IVE A;  3E7A A;  3QFN A;  1FJM A;  2ZBM A;  2WDD A;  2IE4 C;  2WDC A;  3PSO A;  2HYO A;  4WWL A;  4UWQ A;  3QFK A;  1SU1 A;  1S3L A;  2NXF A;  4V0V A;  2JOG A;  4FCX A;  3FLO A;  1UTE A;  4MOY A;  1KBP A;  4NZV A;  3D03 A;  3H60 A;  4B2O A;  3QG5 C;  3H68 A;  3K7W C;  2CV9 A;  3DSC A;  1QHW A;  1M63 A;  1HO5 A;  4ZX2 A;  4M0V A;  3THN A;  2BQ8 X;  5EQV A;  5F3W A;  2NYM C;  1OIE A;  2Z1A A;  3H62 B;  1S70 A;  3C5W C;  3P71 C;  4LU9 A;  2WDE A;  2O8A A;  3H61 A;  1S3N A;  2DXN A;  2IAE C;  3H66 A;  2HY1 A;  3QFO A;  1AUI A;  3H64 A;  3ICF A;  5GTU A;  4JA9 A;  5C1V A;  4KBP A;  3E0J A;  3T1I A;  4DHL A;  4XPN A;  2P6B A;  1HPU A;  3IVD A;  2XMO A;  3QFM A;  2YEQ A;  3V4Y A;  4ORA A;  4LAC C;  3HVQ A;  2R17 A;  3E7B A;  4J6O A;  3KBP A;  3EGH A;  5J28 A;  4I5L C;  1T71 A;  1JK7 A;  2KKN A;  4H1S A;  3ZU0 A;  4FBK A;  4FBQ A;  2A22 A;  4UT3 B;  2QFR A;  2NYL C;  4UT2 A;  4ORB A;  5JJT A;  4UT3 A;  4H2G A;  3PSN A;  3DSD A;  4TUG A;  1OID A;  1II7 A;  2QFP A;  1T70 A;  2QJC A;  2WDF A;  2Q8U A;  2BCD A;  3FGA C;  3JYF A;  5HPE A;  4H2F A;  1WAR A;  1NNW A;  1S3M A;  1V73 A;  4MOV A;  2DFJ A;  1IT6 A;  2GJU A;  2DXL A;  4ORC A;  3ZTV A;  4O24 A;  1QFC A;  3RL3 A;  2HYP A;  1G5B A;  3H67 A;  1OI8 A;  3IB8 A;  4O5G A;  3RL4 A;  1Z2X A;  3C9F A;  4Q7F A;  4IYP C;  1S8E A;  1WAO 1;  4DT2 A;  5DNY A;  3H69 A;  4V0W A;  3H63 A;  4JA7 A;  4MP0 A;  1UF3 A;  2ZOA A;  2Z06 A;  5JPE A;  4H2B A;  3K7V C;  3TGH A;  2ZO9 B;  4G9J A;  1TCO A;  2NPP C;  5INB A;  2USH A;  2O8G A;  1Z2W A;  4H2I A;  3RL5 A;  3AUZ A;  4O4K A;  3THO B;  5IOH A;  4TUI A;  5JPF A;  4IL1 A;  2YVT A;  4OR9 A;  4HD0 A;  3AV0 A;  1XM7 A;  4ZVZ A;  4LTY A;  4O43 A;  4H1Y P;  4YKE A;  2IE3 C;  3RQZ A;  2AHD A;  4FBW A;  4KKZ A;  1HP1 A;  2Z72 A;  3GVE A;  4F0Z A;  1USH A;  3IB7 A; 
#chains in the Genus database with same CATH homology
 3DW8 C;  3EGG A;  4V0X A;  1XZW A;  4DSY A;  3CK2 A;  5B8I A;  1U32 A;  2BDX A;  1S95 A;  1MF8 A;  3N5U A;  1W24 A;  4I5N C;  3LL8 A;  3IVE A;  3E7A A;  3QFN A;  1FJM A;  2ZBM A;  2WDD A;  2IE4 C;  2WDC A;  3PSO A;  2HYO A;  4WWL A;  4UWQ A;  3QFK A;  1SU1 A;  1S3L A;  2NXF A;  4V0V A;  2JOG A;  4FCX A;  3FLO A;  1UTE A;  4MOY A;  1KBP A;  4NZV A;  3D03 A;  3H60 A;  4B2O A;  3QG5 C;  3H68 A;  3K7W C;  2CV9 A;  3DSC A;  1QHW A;  1M63 A;  1HO5 A;  4ZX2 A;  4M0V A;  3THN A;  2BQ8 X;  5EQV A;  5F3W A;  2NYM C;  1OIE A;  2Z1A A;  3H62 B;  1S70 A;  3C5W C;  3P71 C;  4LU9 A;  2WDE A;  2O8A A;  3H61 A;  1S3N A;  2DXN A;  2IAE C;  3H66 A;  2HY1 A;  3QFO A;  1AUI A;  3H64 A;  3ICF A;  5GTU A;  4JA9 A;  5C1V A;  4KBP A;  3E0J A;  3T1I A;  4DHL A;  4XPN A;  2P6B A;  1HPU A;  3IVD A;  2XMO A;  3QFM A;  2YEQ A;  3V4Y A;  4ORA A;  4LAC C;  3HVQ A;  2R17 A;  3E7B A;  4J6O A;  3KBP A;  3EGH A;  5J28 A;  4I5L C;  1T71 A;  1JK7 A;  2KKN A;  4H1S A;  3ZU0 A;  4FBK A;  4FBQ A;  2A22 A;  4UT3 B;  2QFR A;  2NYL C;  4UT2 A;  4ORB A;  5JJT A;  4UT3 A;  4H2G A;  3PSN A;  3DSD A;  4TUG A;  1OID A;  1II7 A;  2QFP A;  1T70 A;  2QJC A;  2WDF A;  2Q8U A;  2BCD A;  3FGA C;  3JYF A;  5HPE A;  4H2F A;  1WAR A;  1NNW A;  1S3M A;  1V73 A;  4MOV A;  2DFJ A;  1IT6 A;  2GJU A;  2DXL A;  4ORC A;  3ZTV A;  4O24 A;  1QFC A;  3RL3 A;  2HYP A;  1G5B A;  3H67 A;  1OI8 A;  3IB8 A;  4O5G A;  3RL4 A;  1Z2X A;  3C9F A;  4Q7F A;  4IYP C;  1S8E A;  1WAO 1;  4DT2 A;  5DNY A;  3H69 A;  4V0W A;  3H63 A;  4JA7 A;  4MP0 A;  1UF3 A;  2ZOA A;  2Z06 A;  5JPE A;  4H2B A;  3K7V C;  3TGH A;  2ZO9 B;  4G9J A;  1TCO A;  2NPP C;  5INB A;  2USH A;  2O8G A;  1Z2W A;  4H2I A;  3RL5 A;  3AUZ A;  4O4K A;  3THO B;  5IOH A;  4TUI A;  5JPF A;  4IL1 A;  2YVT A;  4OR9 A;  4HD0 A;  3AV0 A;  1XM7 A;  4ZVZ A;  4LTY A;  4O43 A;  4H1Y P;  4YKE A;  2IE3 C;  3RQZ A;  2AHD A;  4FBW A;  4KKZ A;  1HP1 A;  2Z72 A;  3GVE A;  4F0Z A;  1USH A;  3IB7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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