1MF8A

Crystal structure of human calcineurin complexed with cyclosporin a and human cyclophilin
Total Genus 121
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
121
sequence length
352
structure length
352
Chain Sequence
AVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/isomerase/immunosuppressant
molecule keywords CALMODULIN-DEPENDENT CALCINEURIN A SUBUNIT, ALPHA ISOFORM
publication title Crystal Structure of Human Calcineurin Complexed with Cyclosporin a and Human Cyclophilin
pubmed doi rcsb
source organism Homo sapiens
total genus 121
structure length 352
sequence length 352
ec nomenclature ec 3.1.3.16: Protein-serine/threonine phosphatase.
pdb deposition date 2002-08-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 1mf8A00
4LACC 3QFOA 4V0WA 3IB7A 4FCXA 4J6OA 1WAO1 1S3MA 3H67A 3QFKA 3DSCA 3QFNA 2P6BA 4LU9A 5J28A 3KBPA 2A22A 3RL5A 1XM7A 4ZX2A 4IL1A 3H68A 1WARA 1S8EA 3EGHA 4B2OA 5JPEA 3DSDA 2JOGA 2NPPC 2XMOA 3H60A 4ORAA 3V4YA 3IVEA 3RL3A 5JJTA 4KBPA 4KKZA 4MOYA 5IOHA 4V0VA 2BCDA 3K7VC 3FGAC 3C9FA 4FBWA 5JPFA 2YVTA 4DT2A 1M63A 2GJUA 3EGGA 3P71C 3C5WC 1HO5A 4FBQA 1Z2XA 1XZWA 3QG5C 4H2GA 2IE4C 3N5UA 2DFJA 2Z1AA 2HYPA 3RQZA 3PSOA 5INBA 4O24A 3H66A 4JA9A 1T70A 3H69A 4ORCA 4ORBA 3PSNA 1FJMA 1HPUA 5C1VA 4O5GA 2NYLC 4V0XA 5DNYA 1S95A 1W24A 4H2BA 1U32A 2O8GA 2AHDA 3DW8C 2WDCA 1TCOA 2Z72A 3QFMA 2WDFA 5B8IA 4JA7A 3K7WC 3THNA 2QFPA 1V73A 4G9JA 2QJCA 4ZVZA 1AUIA 3GVEA 2R17A 3JYFA 4F0ZA 2HY1A 1JK7A 4UT3A 4XPNA 4H2IA 4MP0A 1OIDA 1OI8A 2IE3C 4DHLA 3TGHA 4Q7FA 3CK2A 3H61A 4O43A 4UT3B 4DSYA 4HD0A 5F3WA 4LTYA 3IB8A 4M0VA 3T1IA 3H64A 1T71A 2ZBMA 1S70A 1SU1A 2KKNA 5HPEA 2WDDA 1UF3A 3HVQA 2WDEA 1QHWA 2Q8UA 2QFRA 3ZU0A 3ZTVA 2Z06A 1UTEA 3AV0A 3RL4A 4NZVA 3THOB 4I5NC 1S3NA 1NNWA 4IYPC 3H63A 1QFCA 2USHA 1IT6A 1G5BA 3E7AA 3LL8A 4FBKA 4H2FA 4I5LC 1OIEA 1KBPA 1USHA 3E7BA 4H1YP 4H1SA 4YKEA 1II7A 2NXFA 2HYOA 3ICFA 2CV9A 4UWQA 2BDXA 3AUZA 1HP1A 2IAEC 4TUGA 3H62B 4O4KA 4OR9A 4WWLA 1MF8A 5GTUA 3IVDA 4TUIA 1Z2WA 1S3LA 2BQ8X 4MOVA 4UT2A 2O8AA 2NYMC 5EQVA
chains in the Genus database with same CATH superfamily
4LACC 3QFOA 4V0WA 3IB7A 4FCXA 3E0JA 1WAO1 1S3MA 3H67A 3QFKA 4J6OA 3DSCA 3QFNA 2P6BA 4LU9A 5J28A 3KBPA 2A22A 3RL5A 1XM7A 4ZX2A 4IL1A 3H68A 3FLOA 1WARA 1S8EA 3EGHA 4B2OA 5JPEA 3DSDA 2JOGA 2NPPC 2XMOA 3H60A 4ORAA 3V4YA 3IVEA 3RL3A 5JJTA 2DXNA 4KBPA 4KKZA 4MOYA 5IOHA 4V0VA 2BCDA 3K7VC 3FGAC 3C9FA 4FBWA 5JPFA 2YVTA 4DT2A 1M63A 2GJUA 3EGGA 3P71C 3C5WC 1HO5A 4FBQA 1Z2XA 1XZWA 2ZO9B 3QG5C 2IE4C 4H2GA 3N5UA 2DFJA 2Z1AA 2HYPA 3RQZA 3PSOA 5INBA 2YEQA 4O24A 3H66A 4JA9A 1T70A 3H69A 4ORCA 4ORBA 3PSNA 1FJMA 1HPUA 5C1VA 2ZOAA 4O5GA 2NYLC 4V0XA 5DNYA 1S95A 1W24A 4H2BA 1U32A 2O8GA 2AHDA 3DW8C 2WDCA 1TCOA 2Z72A 3QFMA 2WDFA 5B8IA 4JA7A 3K7WC 3THNA 2QFPA 1V73A 4G9JA 2QJCA 4ZVZA 1AUIA 3GVEA 2R17A 3JYFA 4F0ZA 2HY1A 1JK7A 4UT3A 4XPNA 4H2IA 4MP0A 1OIDA 1OI8A 2IE3C 4DHLA 3TGHA 4Q7FA 3CK2A 3H61A 4O43A 4UT3B 4DSYA 4HD0A 5F3WA 4LTYA 3IB8A 4M0VA 3T1IA 3H64A 1T71A 2ZBMA 1S70A 1SU1A 2DXLA 2KKNA 2WDDA 1UF3A 3HVQA 2WDEA 5HPEA 1QHWA 2Q8UA 2QFRA 3ZU0A 3D03A 3ZTVA 2Z06A 1UTEA 3AV0A 3RL4A 4NZVA 3THOB 4I5NC 1S3NA 1NNWA 4IYPC 3H63A 1QFCA 2USHA 1IT6A 1G5BA 3E7AA 3LL8A 4FBKA 4H2FA 4I5LC 1OIEA 1KBPA 1USHA 3E7BA 4H1YP 4H1SA 4YKEA 1II7A 2NXFA 2HYOA 3ICFA 2CV9A 4UWQA 2BDXA 3AUZA 1HP1A 2IAEC 4TUGA 3H62B 4O4KA 4OR9A 4WWLA 1MF8A 5GTUA 3IVDA 4TUIA 1Z2WA 1S3LA 2BQ8X 4MOVA 4UT2A 2O8AA 2NYMC 5EQVA
chains in the Genus database with same CATH topology
4LACC 3QFOA 4V0WA 3IB7A 4FCXA 3E0JA 1WAO1 1S3MA 3H67A 3QFKA 4J6OA 3DSCA 3QFNA 2P6BA 4LU9A 5J28A 3KBPA 2A22A 3RL5A 1XM7A 4ZX2A 4IL1A 3H68A 3FLOA 1WARA 1S8EA 3EGHA 4B2OA 5JPEA 3DSDA 2JOGA 2NPPC 2XMOA 3H60A 4ORAA 3V4YA 3IVEA 3RL3A 5JJTA 2DXNA 4KBPA 4KKZA 4MOYA 5IOHA 4V0VA 2BCDA 3K7VC 3FGAC 3C9FA 4FBWA 5JPFA 2YVTA 4DT2A 1M63A 2GJUA 3EGGA 3P71C 3C5WC 1HO5A 4FBQA 1Z2XA 1XZWA 2ZO9B 3QG5C 2IE4C 4H2GA 3N5UA 2DFJA 2Z1AA 2HYPA 3RQZA 3PSOA 5INBA 2YEQA 4O24A 3H66A 4JA9A 1T70A 3H69A 4ORCA 4ORBA 3PSNA 1FJMA 1HPUA 5C1VA 2ZOAA 4O5GA 2NYLC 4V0XA 5DNYA 1S95A 1W24A 4H2BA 1U32A 2O8GA 2AHDA 3DW8C 2WDCA 1TCOA 2Z72A 3QFMA 2WDFA 5B8IA 4JA7A 3K7WC 3THNA 2QFPA 1V73A 4G9JA 2QJCA 4ZVZA 1AUIA 3GVEA 2R17A 3JYFA 4F0ZA 2HY1A 1JK7A 4UT3A 4XPNA 4H2IA 4MP0A 1OIDA 1OI8A 2IE3C 4DHLA 3TGHA 4Q7FA 3CK2A 3H61A 4O43A 4UT3B 4DSYA 4HD0A 5F3WA 4LTYA 3IB8A 4M0VA 3T1IA 3H64A 1T71A 2ZBMA 1S70A 1SU1A 2DXLA 2KKNA 2WDDA 1UF3A 3HVQA 2WDEA 5HPEA 1QHWA 2Q8UA 2QFRA 3ZU0A 3D03A 3ZTVA 2Z06A 1UTEA 3AV0A 3RL4A 4NZVA 3THOB 4I5NC 1S3NA 1NNWA 4IYPC 3H63A 1QFCA 2USHA 1IT6A 1G5BA 3E7AA 3LL8A 4FBKA 4H2FA 4I5LC 1OIEA 1KBPA 1USHA 3E7BA 4H1YP 4H1SA 4YKEA 1II7A 2NXFA 2HYOA 3ICFA 2CV9A 4UWQA 2BDXA 3AUZA 1HP1A 2IAEC 4TUGA 3H62B 4O4KA 4OR9A 4WWLA 1MF8A 5GTUA 3IVDA 4TUIA 1Z2WA 1S3LA 2BQ8X 4MOVA 4UT2A 2O8AA 2NYMC 5EQVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LAC C;  3QFO A;  4V0W A;  3IB7 A;  4FCX A;  4J6O A;  1WAO 1;  1S3M A;  3H67 A;  3QFK A;  3DSC A;  3QFN A;  2P6B A;  4LU9 A;  5J28 A;  3KBP A;  2A22 A;  3RL5 A;  1XM7 A;  4ZX2 A;  4IL1 A;  3H68 A;  1WAR A;  1S8E A;  3EGH A;  4B2O A;  5JPE A;  3DSD A;  2JOG A;  2NPP C;  2XMO A;  3H60 A;  4ORA A;  3V4Y A;  3IVE A;  3RL3 A;  5JJT A;  4KBP A;  4KKZ A;  4MOY A;  5IOH A;  4V0V A;  2BCD A;  3K7V C;  3FGA C;  3C9F A;  4FBW A;  5JPF A;  2YVT A;  4DT2 A;  1M63 A;  2GJU A;  3EGG A;  3P71 C;  3C5W C;  1HO5 A;  4FBQ A;  1Z2X A;  1XZW A;  3QG5 C;  4H2G A;  2IE4 C;  3N5U A;  2DFJ A;  2Z1A A;  2HYP A;  3RQZ A;  3PSO A;  5INB A;  4O24 A;  3H66 A;  4JA9 A;  1T70 A;  3H69 A;  4ORC A;  4ORB A;  3PSN A;  1FJM A;  1HPU A;  5C1V A;  4O5G A;  2NYL C;  4V0X A;  5DNY A;  1S95 A;  1W24 A;  4H2B A;  1U32 A;  2O8G A;  2AHD A;  3DW8 C;  2WDC A;  1TCO A;  2Z72 A;  3QFM A;  2WDF A;  5B8I A;  4JA7 A;  3K7W C;  3THN A;  2QFP A;  1V73 A;  4G9J A;  2QJC A;  4ZVZ A;  1AUI A;  3GVE A;  2R17 A;  3JYF A;  4F0Z A;  2HY1 A;  1JK7 A;  4UT3 A;  4XPN A;  4H2I A;  4MP0 A;  1OID A;  1OI8 A;  2IE3 C;  4DHL A;  3TGH A;  4Q7F A;  3CK2 A;  3H61 A;  4O43 A;  4UT3 B;  4DSY A;  4HD0 A;  5F3W A;  4LTY A;  3IB8 A;  4M0V A;  3T1I A;  3H64 A;  1T71 A;  2ZBM A;  1S70 A;  1SU1 A;  2KKN A;  5HPE A;  2WDD A;  1UF3 A;  3HVQ A;  2WDE A;  1QHW A;  2Q8U A;  2QFR A;  3ZU0 A;  3ZTV A;  2Z06 A;  1UTE A;  3AV0 A;  3RL4 A;  4NZV A;  3THO B;  4I5N C;  1S3N A;  1NNW A;  4IYP C;  3H63 A;  1QFC A;  2USH A;  1IT6 A;  1G5B A;  3E7A A;  3LL8 A;  4FBK A;  4H2F A;  4I5L C;  1OIE A;  1KBP A;  1USH A;  3E7B A;  4H1Y P;  4H1S A;  4YKE A;  1II7 A;  2NXF A;  2HYO A;  3ICF A;  2CV9 A;  4UWQ A;  2BDX A;  3AUZ A;  1HP1 A;  2IAE C;  4TUG A;  3H62 B;  4O4K A;  4OR9 A;  4WWL A;  1MF8 A;  5GTU A;  3IVD A;  4TUI A;  1Z2W A;  1S3L A;  2BQ8 X;  4MOV A;  4UT2 A;  2O8A A;  2NYM C;  5EQV A; 
#chains in the Genus database with same CATH topology
 4LAC C;  3QFO A;  4V0W A;  3IB7 A;  4FCX A;  3E0J A;  1WAO 1;  1S3M A;  3H67 A;  3QFK A;  4J6O A;  3DSC A;  3QFN A;  2P6B A;  4LU9 A;  5J28 A;  3KBP A;  2A22 A;  3RL5 A;  1XM7 A;  4ZX2 A;  4IL1 A;  3H68 A;  3FLO A;  1WAR A;  1S8E A;  3EGH A;  4B2O A;  5JPE A;  3DSD A;  2JOG A;  2NPP C;  2XMO A;  3H60 A;  4ORA A;  3V4Y A;  3IVE A;  3RL3 A;  5JJT A;  2DXN A;  4KBP A;  4KKZ A;  4MOY A;  5IOH A;  4V0V A;  2BCD A;  3K7V C;  3FGA C;  3C9F A;  4FBW A;  5JPF A;  2YVT A;  4DT2 A;  1M63 A;  2GJU A;  3EGG A;  3P71 C;  3C5W C;  1HO5 A;  4FBQ A;  1Z2X A;  1XZW A;  2ZO9 B;  3QG5 C;  2IE4 C;  4H2G A;  3N5U A;  2DFJ A;  2Z1A A;  2HYP A;  3RQZ A;  3PSO A;  5INB A;  2YEQ A;  4O24 A;  3H66 A;  4JA9 A;  1T70 A;  3H69 A;  4ORC A;  4ORB A;  3PSN A;  1FJM A;  1HPU A;  5C1V A;  2ZOA A;  4O5G A;  2NYL C;  4V0X A;  5DNY A;  1S95 A;  1W24 A;  4H2B A;  1U32 A;  2O8G A;  2AHD A;  3DW8 C;  2WDC A;  1TCO A;  2Z72 A;  3QFM A;  2WDF A;  5B8I A;  4JA7 A;  3K7W C;  3THN A;  2QFP A;  1V73 A;  4G9J A;  2QJC A;  4ZVZ A;  1AUI A;  3GVE A;  2R17 A;  3JYF A;  4F0Z A;  2HY1 A;  1JK7 A;  4UT3 A;  4XPN A;  4H2I A;  4MP0 A;  1OID A;  1OI8 A;  2IE3 C;  4DHL A;  3TGH A;  4Q7F A;  3CK2 A;  3H61 A;  4O43 A;  4UT3 B;  4DSY A;  4HD0 A;  5F3W A;  4LTY A;  3IB8 A;  4M0V A;  3T1I A;  3H64 A;  1T71 A;  2ZBM A;  1S70 A;  1SU1 A;  2DXL A;  2KKN A;  2WDD A;  1UF3 A;  3HVQ A;  2WDE A;  5HPE A;  1QHW A;  2Q8U A;  2QFR A;  3ZU0 A;  3D03 A;  3ZTV A;  2Z06 A;  1UTE A;  3AV0 A;  3RL4 A;  4NZV A;  3THO B;  4I5N C;  1S3N A;  1NNW A;  4IYP C;  3H63 A;  1QFC A;  2USH A;  1IT6 A;  1G5B A;  3E7A A;  3LL8 A;  4FBK A;  4H2F A;  4I5L C;  1OIE A;  1KBP A;  1USH A;  3E7B A;  4H1Y P;  4H1S A;  4YKE A;  1II7 A;  2NXF A;  2HYO A;  3ICF A;  2CV9 A;  4UWQ A;  2BDX A;  3AUZ A;  1HP1 A;  2IAE C;  4TUG A;  3H62 B;  4O4K A;  4OR9 A;  4WWL A;  1MF8 A;  5GTU A;  3IVD A;  4TUI A;  1Z2W A;  1S3L A;  2BQ8 X;  4MOV A;  4UT2 A;  2O8A A;  2NYM C;  5EQV A; 
#chains in the Genus database with same CATH homology
 4LAC C;  3QFO A;  4V0W A;  3IB7 A;  4FCX A;  3E0J A;  1WAO 1;  1S3M A;  3H67 A;  3QFK A;  4J6O A;  3DSC A;  3QFN A;  2P6B A;  4LU9 A;  5J28 A;  3KBP A;  2A22 A;  3RL5 A;  1XM7 A;  4ZX2 A;  4IL1 A;  3H68 A;  3FLO A;  1WAR A;  1S8E A;  3EGH A;  4B2O A;  5JPE A;  3DSD A;  2JOG A;  2NPP C;  2XMO A;  3H60 A;  4ORA A;  3V4Y A;  3IVE A;  3RL3 A;  5JJT A;  2DXN A;  4KBP A;  4KKZ A;  4MOY A;  5IOH A;  4V0V A;  2BCD A;  3K7V C;  3FGA C;  3C9F A;  4FBW A;  5JPF A;  2YVT A;  4DT2 A;  1M63 A;  2GJU A;  3EGG A;  3P71 C;  3C5W C;  1HO5 A;  4FBQ A;  1Z2X A;  1XZW A;  2ZO9 B;  3QG5 C;  2IE4 C;  4H2G A;  3N5U A;  2DFJ A;  2Z1A A;  2HYP A;  3RQZ A;  3PSO A;  5INB A;  2YEQ A;  4O24 A;  3H66 A;  4JA9 A;  1T70 A;  3H69 A;  4ORC A;  4ORB A;  3PSN A;  1FJM A;  1HPU A;  5C1V A;  2ZOA A;  4O5G A;  2NYL C;  4V0X A;  5DNY A;  1S95 A;  1W24 A;  4H2B A;  1U32 A;  2O8G A;  2AHD A;  3DW8 C;  2WDC A;  1TCO A;  2Z72 A;  3QFM A;  2WDF A;  5B8I A;  4JA7 A;  3K7W C;  3THN A;  2QFP A;  1V73 A;  4G9J A;  2QJC A;  4ZVZ A;  1AUI A;  3GVE A;  2R17 A;  3JYF A;  4F0Z A;  2HY1 A;  1JK7 A;  4UT3 A;  4XPN A;  4H2I A;  4MP0 A;  1OID A;  1OI8 A;  2IE3 C;  4DHL A;  3TGH A;  4Q7F A;  3CK2 A;  3H61 A;  4O43 A;  4UT3 B;  4DSY A;  4HD0 A;  5F3W A;  4LTY A;  3IB8 A;  4M0V A;  3T1I A;  3H64 A;  1T71 A;  2ZBM A;  1S70 A;  1SU1 A;  2DXL A;  2KKN A;  2WDD A;  1UF3 A;  3HVQ A;  2WDE A;  5HPE A;  1QHW A;  2Q8U A;  2QFR A;  3ZU0 A;  3D03 A;  3ZTV A;  2Z06 A;  1UTE A;  3AV0 A;  3RL4 A;  4NZV A;  3THO B;  4I5N C;  1S3N A;  1NNW A;  4IYP C;  3H63 A;  1QFC A;  2USH A;  1IT6 A;  1G5B A;  3E7A A;  3LL8 A;  4FBK A;  4H2F A;  4I5L C;  1OIE A;  1KBP A;  1USH A;  3E7B A;  4H1Y P;  4H1S A;  4YKE A;  1II7 A;  2NXF A;  2HYO A;  3ICF A;  2CV9 A;  4UWQ A;  2BDX A;  3AUZ A;  1HP1 A;  2IAE C;  4TUG A;  3H62 B;  4O4K A;  4OR9 A;  4WWL A;  1MF8 A;  5GTU A;  3IVD A;  4TUI A;  1Z2W A;  1S3L A;  2BQ8 X;  4MOV A;  4UT2 A;  2O8A A;  2NYM C;  5EQV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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