2HYOA

Crystal structure of rv0805 n97a mutant
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
256
structure length
227
Chain Sequence
PRPDYVLLHISDTHLIDADDRLGELLEQLNQSGLRPDAIVFTGDLADKGEPAAYRKLRGLVEPFAAQLGAELVWVMGAHDDRAELRKFLLDEAPSMAPLDRVCMIDGLRIIVLDTSVPGHHHGEIRASQLGWLAEELATPAPDGTILALHHPPIPSVLDMAVTVELRDQAALGRVLRGTDVRAILAGHLHYSTNATFVGIPVSVASATCGCNLVHVYPDTVVHSVIP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
source organism Mycobacterium tuberculosis
publication title Structural and Biochemical Analysis of the Rv0805 Cyclic Nucleotide Phosphodiesterase from Mycobacterium tuberculosis.
pubmed doi rcsb
molecule keywords Rv0805N97A
total genus 70
structure length 227
sequence length 256
ec nomenclature ec 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
pdb deposition date 2006-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2hyoA00
3IB7A 2P6BA 4ORBA 4I5NC 5J28A 2NXFA 4DHLA 3RL3A 3EGHA 3H63A 3GVEA 2JOGA 2QJCA 3K7VC 4H1YP 1OI8A 1FJMA 3AV0A 1S3LA 3V4YA 1OIDA 1QHWA 1TCOA 2O8GA 4KBPA 3QFKA 4O4KA 4M0VA 2WDCA 3DW8C 4MP0A 4HD0A 3CK2A 3H66A 4O5GA 3C9FA 4IL1A 4DSYA 5DNYA 4O24A 3TGHA 3ZTVA 1QFCA 2NYLC 2QFPA 4ORAA 2Z1AA 2IAEC 4UT3A 1USHA 3H60A 4G9JA 3H62B 1U32A 4F0ZA 1WAO1 3KBPA 1S95A 2BCDA 1S3NA 2Z06A 3QFNA 2NPPC 5GTUA 5HPEA 1NNWA 1XZWA 3QG5C 3H64A 3RL5A 4ORCA 2XMOA 4TUGA 5JPEA 4FBQA 1T70A 4FBWA 3H68A 2AHDA 1MF8A 3AUZA 4UT3B 2IE4C 2HY1A 4J6OA 4MOVA 4FCXA 1M63A 2A22A 5JPFA 2WDDA 3IB8A 1UF3A 2HYOA 2QFRA 3IVDA 2GJUA 3IVEA 4LACC 5EQVA 3RQZA 2USHA 1AUIA 3E7BA 5F3WA 2ZBMA 4ZX2A 3K7WC 5JJTA 1V73A 4UWQA 5C1VA 4MOYA 2Z72A 4UT2A 1Z2XA 3H69A 3ICFA 1II7A 4O43A 5B8IA 1HP1A 4H1SA 1SU1A 4WWLA 5INBA 4NZVA 4V0WA 1KBPA 1W24A 4H2IA 1OIEA 1WARA 5IOHA 3PSOA 2IE3C 4XPNA 4FBKA 2HYPA 4ZVZA 1UTEA 2R17A 4OR9A 1XM7A 2DFJA 4H2BA 1HPUA 4TUIA 4V0XA 2YVTA 1S8EA 2BQ8X 2WDFA 4YKEA 4LU9A 2BDXA 2O8AA 3H61A 2CV9A 3T1IA 3JYFA 3THOB 4Q7FA 4DT2A 2Q8UA 2WDEA 4B2OA 1Z2WA 3RL4A 3QFOA 3LL8A 3QFMA 4IYPC 3ZU0A 3THNA 2NYMC 3FGAC 4JA9A 3PSNA 3HVQA 4H2GA 1S3MA 4KKZA 1G5BA 2KKNA 3DSCA 4V0VA 1S70A 4H2FA 3H67A 4I5LC 1HO5A 3C5WC 1IT6A 3N5UA 1T71A 4LTYA 3DSDA 3P71C 1JK7A 3E7AA 4JA7A 3EGGA
chains in the Genus database with same CATH superfamily
3IB7A 2P6BA 4ORBA 4I5NC 5J28A 2NXFA 4DHLA 3RL3A 3EGHA 2YEQA 2ZOAA 3GVEA 2JOGA 2QJCA 3H63A 3K7VC 4H1YP 1OI8A 1FJMA 3AV0A 1S3LA 3V4YA 1OIDA 1QHWA 1TCOA 3E0JA 2DXLA 2O8GA 4KBPA 3QFKA 4O4KA 4M0VA 2WDCA 3DW8C 4MP0A 4HD0A 3CK2A 3H66A 4O5GA 3C9FA 4IL1A 4DSYA 5DNYA 4O24A 3TGHA 3ZTVA 1QFCA 2NYLC 2QFPA 4ORAA 2Z1AA 2IAEC 4UT3A 1USHA 3H60A 4G9JA 3H62B 1U32A 4F0ZA 1WAO1 3KBPA 1S95A 2BCDA 1S3NA 2Z06A 3QFNA 2NPPC 5GTUA 5HPEA 1NNWA 1XZWA 3QG5C 3H64A 3RL5A 4ORCA 2XMOA 4TUGA 5JPEA 4FBQA 1T70A 4FBWA 3H68A 2AHDA 1MF8A 2DXNA 3AUZA 4UT3B 2IE4C 2HY1A 4J6OA 4MOVA 4FCXA 1M63A 2A22A 5JPFA 2WDDA 3IB8A 1UF3A 2HYOA 2QFRA 3IVDA 2GJUA 3IVEA 4LACC 5EQVA 3RQZA 2USHA 1AUIA 3E7BA 5F3WA 2ZBMA 3D03A 4ZX2A 3K7WC 5JJTA 1V73A 4UWQA 5C1VA 4MOYA 2Z72A 4UT2A 1Z2XA 3H69A 3ICFA 1II7A 4O43A 5B8IA 1HP1A 4H1SA 1SU1A 4WWLA 5INBA 4NZVA 4V0WA 1KBPA 1W24A 4H2IA 1OIEA 1WARA 5IOHA 3PSOA 2IE3C 4XPNA 4FBKA 2HYPA 4ZVZA 1UTEA 2R17A 4OR9A 1XM7A 2DFJA 4H2BA 1HPUA 4TUIA 4V0XA 2YVTA 1S8EA 2BQ8X 2WDFA 2ZO9B 4YKEA 4LU9A 2BDXA 2O8AA 3H61A 2CV9A 3T1IA 3JYFA 3THOB 4Q7FA 4DT2A 2Q8UA 2WDEA 4B2OA 1Z2WA 3RL4A 3QFOA 3LL8A 3QFMA 4IYPC 3ZU0A 3THNA 2NYMC 3FGAC 4JA9A 3PSNA 3HVQA 4H2GA 3FLOA 1S3MA 4KKZA 1G5BA 2KKNA 3DSCA 4V0VA 1S70A 4H2FA 3H67A 4I5LC 1HO5A 3C5WC 1IT6A 3N5UA 1T71A 4LTYA 3DSDA 3P71C 1JK7A 3E7AA 4JA7A 3EGGA
chains in the Genus database with same CATH topology
3IB7A 2P6BA 4ORBA 4I5NC 5J28A 2NXFA 4DHLA 3RL3A 3EGHA 2YEQA 2ZOAA 3GVEA 2JOGA 2QJCA 3H63A 3K7VC 4H1YP 1OI8A 1FJMA 3AV0A 1S3LA 3V4YA 1OIDA 1QHWA 1TCOA 3E0JA 2DXLA 2O8GA 4KBPA 3QFKA 4O4KA 4M0VA 2WDCA 3DW8C 4MP0A 4HD0A 3CK2A 3H66A 4O5GA 3C9FA 4IL1A 4DSYA 5DNYA 4O24A 3TGHA 3ZTVA 1QFCA 2NYLC 2QFPA 4ORAA 2Z1AA 2IAEC 4UT3A 1USHA 3H60A 4G9JA 3H62B 1U32A 4F0ZA 1WAO1 3KBPA 1S95A 2BCDA 1S3NA 2Z06A 3QFNA 2NPPC 5GTUA 5HPEA 1NNWA 1XZWA 3QG5C 3H64A 3RL5A 4ORCA 2XMOA 4TUGA 5JPEA 4FBQA 1T70A 4FBWA 3H68A 2AHDA 1MF8A 2DXNA 3AUZA 4UT3B 2IE4C 2HY1A 4J6OA 4MOVA 4FCXA 1M63A 2A22A 5JPFA 2WDDA 3IB8A 1UF3A 2HYOA 2QFRA 3IVDA 2GJUA 3IVEA 4LACC 5EQVA 3RQZA 2USHA 1AUIA 3E7BA 5F3WA 2ZBMA 3D03A 4ZX2A 3K7WC 5JJTA 1V73A 4UWQA 5C1VA 4MOYA 2Z72A 4UT2A 1Z2XA 3H69A 3ICFA 1II7A 4O43A 5B8IA 1HP1A 4H1SA 1SU1A 4WWLA 5INBA 4NZVA 4V0WA 1KBPA 1W24A 4H2IA 1OIEA 1WARA 5IOHA 3PSOA 2IE3C 4XPNA 4FBKA 2HYPA 4ZVZA 1UTEA 2R17A 4OR9A 1XM7A 2DFJA 4H2BA 1HPUA 4TUIA 4V0XA 2YVTA 1S8EA 2BQ8X 2WDFA 2ZO9B 4YKEA 4LU9A 2BDXA 2O8AA 3H61A 2CV9A 3T1IA 3JYFA 3THOB 4Q7FA 4DT2A 2Q8UA 2WDEA 4B2OA 1Z2WA 3RL4A 3QFOA 3LL8A 3QFMA 4IYPC 3ZU0A 3THNA 2NYMC 3FGAC 4JA9A 3PSNA 3HVQA 4H2GA 3FLOA 1S3MA 4KKZA 1G5BA 2KKNA 3DSCA 4V0VA 1S70A 4H2FA 3H67A 4I5LC 1HO5A 3C5WC 1IT6A 3N5UA 1T71A 4LTYA 3DSDA 3P71C 1JK7A 3E7AA 4JA7A 3EGGA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3IB7 A;  2P6B A;  4ORB A;  4I5N C;  5J28 A;  2NXF A;  4DHL A;  3RL3 A;  3EGH A;  3H63 A;  3GVE A;  2JOG A;  2QJC A;  3K7V C;  4H1Y P;  1OI8 A;  1FJM A;  3AV0 A;  1S3L A;  3V4Y A;  1OID A;  1QHW A;  1TCO A;  2O8G A;  4KBP A;  3QFK A;  4O4K A;  4M0V A;  2WDC A;  3DW8 C;  4MP0 A;  4HD0 A;  3CK2 A;  3H66 A;  4O5G A;  3C9F A;  4IL1 A;  4DSY A;  5DNY A;  4O24 A;  3TGH A;  3ZTV A;  1QFC A;  2NYL C;  2QFP A;  4ORA A;  2Z1A A;  2IAE C;  4UT3 A;  1USH A;  3H60 A;  4G9J A;  3H62 B;  1U32 A;  4F0Z A;  1WAO 1;  3KBP A;  1S95 A;  2BCD A;  1S3N A;  2Z06 A;  3QFN A;  2NPP C;  5GTU A;  5HPE A;  1NNW A;  1XZW A;  3QG5 C;  3H64 A;  3RL5 A;  4ORC A;  2XMO A;  4TUG A;  5JPE A;  4FBQ A;  1T70 A;  4FBW A;  3H68 A;  2AHD A;  1MF8 A;  3AUZ A;  4UT3 B;  2IE4 C;  2HY1 A;  4J6O A;  4MOV A;  4FCX A;  1M63 A;  2A22 A;  5JPF A;  2WDD A;  3IB8 A;  1UF3 A;  2HYO A;  2QFR A;  3IVD A;  2GJU A;  3IVE A;  4LAC C;  5EQV A;  3RQZ A;  2USH A;  1AUI A;  3E7B A;  5F3W A;  2ZBM A;  4ZX2 A;  3K7W C;  5JJT A;  1V73 A;  4UWQ A;  5C1V A;  4MOY A;  2Z72 A;  4UT2 A;  1Z2X A;  3H69 A;  3ICF A;  1II7 A;  4O43 A;  5B8I A;  1HP1 A;  4H1S A;  1SU1 A;  4WWL A;  5INB A;  4NZV A;  4V0W A;  1KBP A;  1W24 A;  4H2I A;  1OIE A;  1WAR A;  5IOH A;  3PSO A;  2IE3 C;  4XPN A;  4FBK A;  2HYP A;  4ZVZ A;  1UTE A;  2R17 A;  4OR9 A;  1XM7 A;  2DFJ A;  4H2B A;  1HPU A;  4TUI A;  4V0X A;  2YVT A;  1S8E A;  2BQ8 X;  2WDF A;  4YKE A;  4LU9 A;  2BDX A;  2O8A A;  3H61 A;  2CV9 A;  3T1I A;  3JYF A;  3THO B;  4Q7F A;  4DT2 A;  2Q8U A;  2WDE A;  4B2O A;  1Z2W A;  3RL4 A;  3QFO A;  3LL8 A;  3QFM A;  4IYP C;  3ZU0 A;  3THN A;  2NYM C;  3FGA C;  4JA9 A;  3PSN A;  3HVQ A;  4H2G A;  1S3M A;  4KKZ A;  1G5B A;  2KKN A;  3DSC A;  4V0V A;  1S70 A;  4H2F A;  3H67 A;  4I5L C;  1HO5 A;  3C5W C;  1IT6 A;  3N5U A;  1T71 A;  4LTY A;  3DSD A;  3P71 C;  1JK7 A;  3E7A A;  4JA7 A;  3EGG A; 
#chains in the Genus database with same CATH topology
 3IB7 A;  2P6B A;  4ORB A;  4I5N C;  5J28 A;  2NXF A;  4DHL A;  3RL3 A;  3EGH A;  2YEQ A;  2ZOA A;  3GVE A;  2JOG A;  2QJC A;  3H63 A;  3K7V C;  4H1Y P;  1OI8 A;  1FJM A;  3AV0 A;  1S3L A;  3V4Y A;  1OID A;  1QHW A;  1TCO A;  3E0J A;  2DXL A;  2O8G A;  4KBP A;  3QFK A;  4O4K A;  4M0V A;  2WDC A;  3DW8 C;  4MP0 A;  4HD0 A;  3CK2 A;  3H66 A;  4O5G A;  3C9F A;  4IL1 A;  4DSY A;  5DNY A;  4O24 A;  3TGH A;  3ZTV A;  1QFC A;  2NYL C;  2QFP A;  4ORA A;  2Z1A A;  2IAE C;  4UT3 A;  1USH A;  3H60 A;  4G9J A;  3H62 B;  1U32 A;  4F0Z A;  1WAO 1;  3KBP A;  1S95 A;  2BCD A;  1S3N A;  2Z06 A;  3QFN A;  2NPP C;  5GTU A;  5HPE A;  1NNW A;  1XZW A;  3QG5 C;  3H64 A;  3RL5 A;  4ORC A;  2XMO A;  4TUG A;  5JPE A;  4FBQ A;  1T70 A;  4FBW A;  3H68 A;  2AHD A;  1MF8 A;  2DXN A;  3AUZ A;  4UT3 B;  2IE4 C;  2HY1 A;  4J6O A;  4MOV A;  4FCX A;  1M63 A;  2A22 A;  5JPF A;  2WDD A;  3IB8 A;  1UF3 A;  2HYO A;  2QFR A;  3IVD A;  2GJU A;  3IVE A;  4LAC C;  5EQV A;  3RQZ A;  2USH A;  1AUI A;  3E7B A;  5F3W A;  2ZBM A;  3D03 A;  4ZX2 A;  3K7W C;  5JJT A;  1V73 A;  4UWQ A;  5C1V A;  4MOY A;  2Z72 A;  4UT2 A;  1Z2X A;  3H69 A;  3ICF A;  1II7 A;  4O43 A;  5B8I A;  1HP1 A;  4H1S A;  1SU1 A;  4WWL A;  5INB A;  4NZV A;  4V0W A;  1KBP A;  1W24 A;  4H2I A;  1OIE A;  1WAR A;  5IOH A;  3PSO A;  2IE3 C;  4XPN A;  4FBK A;  2HYP A;  4ZVZ A;  1UTE A;  2R17 A;  4OR9 A;  1XM7 A;  2DFJ A;  4H2B A;  1HPU A;  4TUI A;  4V0X A;  2YVT A;  1S8E A;  2BQ8 X;  2WDF A;  2ZO9 B;  4YKE A;  4LU9 A;  2BDX A;  2O8A A;  3H61 A;  2CV9 A;  3T1I A;  3JYF A;  3THO B;  4Q7F A;  4DT2 A;  2Q8U A;  2WDE A;  4B2O A;  1Z2W A;  3RL4 A;  3QFO A;  3LL8 A;  3QFM A;  4IYP C;  3ZU0 A;  3THN A;  2NYM C;  3FGA C;  4JA9 A;  3PSN A;  3HVQ A;  4H2G A;  3FLO A;  1S3M A;  4KKZ A;  1G5B A;  2KKN A;  3DSC A;  4V0V A;  1S70 A;  4H2F A;  3H67 A;  4I5L C;  1HO5 A;  3C5W C;  1IT6 A;  3N5U A;  1T71 A;  4LTY A;  3DSD A;  3P71 C;  1JK7 A;  3E7A A;  4JA7 A;  3EGG A; 
#chains in the Genus database with same CATH homology
 3IB7 A;  2P6B A;  4ORB A;  4I5N C;  5J28 A;  2NXF A;  4DHL A;  3RL3 A;  3EGH A;  2YEQ A;  2ZOA A;  3GVE A;  2JOG A;  2QJC A;  3H63 A;  3K7V C;  4H1Y P;  1OI8 A;  1FJM A;  3AV0 A;  1S3L A;  3V4Y A;  1OID A;  1QHW A;  1TCO A;  3E0J A;  2DXL A;  2O8G A;  4KBP A;  3QFK A;  4O4K A;  4M0V A;  2WDC A;  3DW8 C;  4MP0 A;  4HD0 A;  3CK2 A;  3H66 A;  4O5G A;  3C9F A;  4IL1 A;  4DSY A;  5DNY A;  4O24 A;  3TGH A;  3ZTV A;  1QFC A;  2NYL C;  2QFP A;  4ORA A;  2Z1A A;  2IAE C;  4UT3 A;  1USH A;  3H60 A;  4G9J A;  3H62 B;  1U32 A;  4F0Z A;  1WAO 1;  3KBP A;  1S95 A;  2BCD A;  1S3N A;  2Z06 A;  3QFN A;  2NPP C;  5GTU A;  5HPE A;  1NNW A;  1XZW A;  3QG5 C;  3H64 A;  3RL5 A;  4ORC A;  2XMO A;  4TUG A;  5JPE A;  4FBQ A;  1T70 A;  4FBW A;  3H68 A;  2AHD A;  1MF8 A;  2DXN A;  3AUZ A;  4UT3 B;  2IE4 C;  2HY1 A;  4J6O A;  4MOV A;  4FCX A;  1M63 A;  2A22 A;  5JPF A;  2WDD A;  3IB8 A;  1UF3 A;  2HYO A;  2QFR A;  3IVD A;  2GJU A;  3IVE A;  4LAC C;  5EQV A;  3RQZ A;  2USH A;  1AUI A;  3E7B A;  5F3W A;  2ZBM A;  3D03 A;  4ZX2 A;  3K7W C;  5JJT A;  1V73 A;  4UWQ A;  5C1V A;  4MOY A;  2Z72 A;  4UT2 A;  1Z2X A;  3H69 A;  3ICF A;  1II7 A;  4O43 A;  5B8I A;  1HP1 A;  4H1S A;  1SU1 A;  4WWL A;  5INB A;  4NZV A;  4V0W A;  1KBP A;  1W24 A;  4H2I A;  1OIE A;  1WAR A;  5IOH A;  3PSO A;  2IE3 C;  4XPN A;  4FBK A;  2HYP A;  4ZVZ A;  1UTE A;  2R17 A;  4OR9 A;  1XM7 A;  2DFJ A;  4H2B A;  1HPU A;  4TUI A;  4V0X A;  2YVT A;  1S8E A;  2BQ8 X;  2WDF A;  2ZO9 B;  4YKE A;  4LU9 A;  2BDX A;  2O8A A;  3H61 A;  2CV9 A;  3T1I A;  3JYF A;  3THO B;  4Q7F A;  4DT2 A;  2Q8U A;  2WDE A;  4B2O A;  1Z2W A;  3RL4 A;  3QFO A;  3LL8 A;  3QFM A;  4IYP C;  3ZU0 A;  3THN A;  2NYM C;  3FGA C;  4JA9 A;  3PSN A;  3HVQ A;  4H2G A;  3FLO A;  1S3M A;  4KKZ A;  1G5B A;  2KKN A;  3DSC A;  4V0V A;  1S70 A;  4H2F A;  3H67 A;  4I5L C;  1HO5 A;  3C5W C;  1IT6 A;  3N5U A;  1T71 A;  4LTY A;  3DSD A;  3P71 C;  1JK7 A;  3E7A A;  4JA7 A;  3EGG A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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