3FLOA

Crystal structure of the carboxyl-terminal domain of yeast dna polymerase alpha in complex with its b subunit
Total Genus 123
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
458
structure length
433
Chain Sequence
RTMRQNLQEASDVLDDQIESFTKIIQNHYKLSPNDFADPTIQSQSEIYAVGRIVPDSPTYDKFLNPESLSLETSRMGGVGRRVRLDLSQVNELSFFLGQIVAFKGKNANGDYFTVNSILPLPYPNSPVSTSQELQEFQANLEGSSLKVIVTCGPYFANDNFSLELLQEFIDSINNEVKPHVLIMFGPFIDITHPLIASGKLPNFPQFKTQPKTLDELFLKLFTPILKTISPHIQTVLIPSTKDAISNHAAYPQASLIRKALQLPKRNFKCMANPSSFQINEIYFGCSNVDTFKDLKEVIKGGTTSSRYRLDRVSEHILQQRRYYPIFPGSIRTHISGADLDVSYLGLTEFVGGFSPDIMIIPSELQHFARVVQNVVVINPGRFIRATGNRGSYAQITVQCPDLEDGKLTLVEGEEPVYLHNVWKRARVDLIAS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title 3D architecture of DNA Pol alpha reveals the functional core of multi-subunit replicative polymerases
pubmed doi rcsb
source organism Saccharomyces cerevisiae
molecule tags Transferase
molecule keywords DNA polymerase alpha subunit B
total genus 123
structure length 433
sequence length 458
chains with identical sequence C, E, G
ec nomenclature
pdb deposition date 2008-12-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04042 DNA_pol_E_B DNA polymerase alpha/epsilon subunit B
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.60 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 3floA02
3FLOA
chains in the Genus database with same CATH superfamily
3PSOA 1FJMA 2ZBMA 4FBWA 4TUIA 3H63A 4KKZA 5B8IA 1OI8A 3EGGA 3ICFA 2IE4C 3T1IA 3QFMA 4B2OA 3H66A 4Q7FA 1S3MA 4ORCA 4JA9A 4O43A 3RL3A 5JJTA 1V73A 1QFCA 3H68A 4LTYA 2HYPA 4ZVZA 2JOGA 4J6OA 1TCOA 4UT2A 3DSCA 2NYLC 3RL5A 3DSDA 2GJUA 2NXFA 1HP1A 3GVEA 3V4YA 3TGHA 2O8AA 4H1YP 3E7AA 3AV0A 3EGHA 2QFPA 4O5GA 3H64A 1G5BA 2USHA 3IVEA 3DW8C 4KBPA 5F3WA 4ORBA 5INBA 3IVDA 2ZOAA 2WDDA 2DXNA 4H2IA 3RL4A 1USHA 4DSYA 1WAO1 4V0VA 1T70A 3H61A 5GTUA 1KBPA 4H2FA 2ZO9B 1UF3A 3HVQA 4H2GA 1Z2WA 3E0JA 4G9JA 3PSNA 2A22A 1Z2XA 3JYFA 4UT3B 1JK7A 5HPEA 3H69A 1OIEA 3THOB 3N5UA 2XMOA 4LU9A 2BCDA 1XM7A 4O4KA 1SU1A 3K7VC 5IOHA 1OIDA 4MOYA 1U32A 3H62B 3QG5C 2QFRA 3H60A 1XZWA 4V0XA 4TUGA 1W24A 2YVTA 4FBKA 4DHLA 4YKEA 5DNYA 4HD0A 3THNA 3C5WC 2CV9A 4MOVA 2NPPC 3QFKA 5EQVA 4O24A 2AHDA 5J28A 2DXLA 1WARA 1MF8A 2P6BA 3FLOA 4JA7A 3ZTVA 5JPFA 2HYOA 1HPUA 2YEQA 1S8EA 4H1SA 3ZU0A 3KBPA 1S3NA 2Z06A 3E7BA 3IB8A 3C9FA 3K7WC 1T71A 3LL8A 4I5LC 1UTEA 4XPNA 5C1VA 3P71C 3QFNA 4FCXA 1S95A 2WDCA 3CK2A 1HO5A 3H67A 2DFJA 4OR9A 2Z72A 1IT6A 3QFOA 1AUIA 4NZVA 2NYMC 2BQ8X 1S3LA 4LACC 2HY1A 1M63A 3RQZA 4WWLA 2R17A 4FBQA 4ZX2A 2KKNA 2O8GA 1S70A 5JPEA 4H2BA 1QHWA 4MP0A 4IYPC 2BDXA 2WDEA 1II7A 2QJCA 4I5NC 4ORAA 4IL1A 4V0WA 2IE3C 4M0VA 3AUZA 4UT3A 3FGAC 2IAEC 4DT2A 2Q8UA 2Z1AA 4UWQA 3D03A 2WDFA 3IB7A 4F0ZA 1NNWA
chains in the Genus database with same CATH topology
3PSOA 1FJMA 2ZBMA 4FBWA 4TUIA 3H63A 4KKZA 5B8IA 1OI8A 3EGGA 3ICFA 2IE4C 3T1IA 3QFMA 4B2OA 3H66A 4Q7FA 1S3MA 4ORCA 4JA9A 4O43A 3RL3A 5JJTA 1V73A 1QFCA 3H68A 4LTYA 2HYPA 4ZVZA 2JOGA 4J6OA 1TCOA 4UT2A 3DSCA 2NYLC 3RL5A 3DSDA 2GJUA 2NXFA 1HP1A 3GVEA 3V4YA 3TGHA 2O8AA 4H1YP 3E7AA 3AV0A 3EGHA 2QFPA 4O5GA 3H64A 1G5BA 2USHA 3IVEA 3DW8C 4KBPA 5F3WA 4ORBA 5INBA 3IVDA 2ZOAA 2WDDA 2DXNA 4H2IA 3RL4A 1USHA 4DSYA 1WAO1 4V0VA 1T70A 3H61A 5GTUA 1KBPA 4H2FA 2ZO9B 1UF3A 3HVQA 4H2GA 1Z2WA 3E0JA 4G9JA 3PSNA 2A22A 1Z2XA 3JYFA 4UT3B 1JK7A 5HPEA 3H69A 1OIEA 3THOB 3N5UA 2XMOA 4LU9A 2BCDA 1XM7A 4O4KA 1SU1A 3K7VC 5IOHA 1OIDA 4MOYA 1U32A 3H62B 3QG5C 2QFRA 3H60A 1XZWA 4V0XA 4TUGA 1W24A 2YVTA 4FBKA 4DHLA 4YKEA 5DNYA 4HD0A 3THNA 3C5WC 2CV9A 4MOVA 2NPPC 3QFKA 5EQVA 4O24A 2AHDA 5J28A 2DXLA 1WARA 1MF8A 2P6BA 3FLOA 4JA7A 3ZTVA 5JPFA 2HYOA 1HPUA 2YEQA 1S8EA 4H1SA 3ZU0A 3KBPA 1S3NA 2Z06A 3E7BA 3IB8A 3C9FA 3K7WC 1T71A 3LL8A 4I5LC 1UTEA 4XPNA 5C1VA 3P71C 3QFNA 4FCXA 1S95A 2WDCA 3CK2A 1HO5A 3H67A 2DFJA 4OR9A 2Z72A 1IT6A 3QFOA 1AUIA 4NZVA 2NYMC 2BQ8X 1S3LA 4LACC 2HY1A 1M63A 3RQZA 4WWLA 2R17A 4FBQA 4ZX2A 2KKNA 2O8GA 1S70A 5JPEA 4H2BA 1QHWA 4MP0A 4IYPC 2BDXA 2WDEA 1II7A 2QJCA 4I5NC 4ORAA 4IL1A 4V0WA 2IE3C 4M0VA 3AUZA 4UT3A 3FGAC 2IAEC 4DT2A 2Q8UA 2Z1AA 4UWQA 3D03A 2WDFA 3IB7A 4F0ZA 1NNWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FLO A; 
#chains in the Genus database with same CATH topology
 3PSO A;  1FJM A;  2ZBM A;  4FBW A;  4TUI A;  3H63 A;  4KKZ A;  5B8I A;  1OI8 A;  3EGG A;  3ICF A;  2IE4 C;  3T1I A;  3QFM A;  4B2O A;  3H66 A;  4Q7F A;  1S3M A;  4ORC A;  4JA9 A;  4O43 A;  3RL3 A;  5JJT A;  1V73 A;  1QFC A;  3H68 A;  4LTY A;  2HYP A;  4ZVZ A;  2JOG A;  4J6O A;  1TCO A;  4UT2 A;  3DSC A;  2NYL C;  3RL5 A;  3DSD A;  2GJU A;  2NXF A;  1HP1 A;  3GVE A;  3V4Y A;  3TGH A;  2O8A A;  4H1Y P;  3E7A A;  3AV0 A;  3EGH A;  2QFP A;  4O5G A;  3H64 A;  1G5B A;  2USH A;  3IVE A;  3DW8 C;  4KBP A;  5F3W A;  4ORB A;  5INB A;  3IVD A;  2ZOA A;  2WDD A;  2DXN A;  4H2I A;  3RL4 A;  1USH A;  4DSY A;  1WAO 1;  4V0V A;  1T70 A;  3H61 A;  5GTU A;  1KBP A;  4H2F A;  2ZO9 B;  1UF3 A;  3HVQ A;  4H2G A;  1Z2W A;  3E0J A;  4G9J A;  3PSN A;  2A22 A;  1Z2X A;  3JYF A;  4UT3 B;  1JK7 A;  5HPE A;  3H69 A;  1OIE A;  3THO B;  3N5U A;  2XMO A;  4LU9 A;  2BCD A;  1XM7 A;  4O4K A;  1SU1 A;  3K7V C;  5IOH A;  1OID A;  4MOY A;  1U32 A;  3H62 B;  3QG5 C;  2QFR A;  3H60 A;  1XZW A;  4V0X A;  4TUG A;  1W24 A;  2YVT A;  4FBK A;  4DHL A;  4YKE A;  5DNY A;  4HD0 A;  3THN A;  3C5W C;  2CV9 A;  4MOV A;  2NPP C;  3QFK A;  5EQV A;  4O24 A;  2AHD A;  5J28 A;  2DXL A;  1WAR A;  1MF8 A;  2P6B A;  3FLO A;  4JA7 A;  3ZTV A;  5JPF A;  2HYO A;  1HPU A;  2YEQ A;  1S8E A;  4H1S A;  3ZU0 A;  3KBP A;  1S3N A;  2Z06 A;  3E7B A;  3IB8 A;  3C9F A;  3K7W C;  1T71 A;  3LL8 A;  4I5L C;  1UTE A;  4XPN A;  5C1V A;  3P71 C;  3QFN A;  4FCX A;  1S95 A;  2WDC A;  3CK2 A;  1HO5 A;  3H67 A;  2DFJ A;  4OR9 A;  2Z72 A;  1IT6 A;  3QFO A;  1AUI A;  4NZV A;  2NYM C;  2BQ8 X;  1S3L A;  4LAC C;  2HY1 A;  1M63 A;  3RQZ A;  4WWL A;  2R17 A;  4FBQ A;  4ZX2 A;  2KKN A;  2O8G A;  1S70 A;  5JPE A;  4H2B A;  1QHW A;  4MP0 A;  4IYP C;  2BDX A;  2WDE A;  1II7 A;  2QJC A;  4I5N C;  4ORA A;  4IL1 A;  4V0W A;  2IE3 C;  4M0V A;  3AUZ A;  4UT3 A;  3FGA C;  2IAE C;  4DT2 A;  2Q8U A;  2Z1A A;  4UWQ A;  3D03 A;  2WDF A;  3IB7 A;  4F0Z A;  1NNW A; 
#chains in the Genus database with same CATH homology
 3PSO A;  1FJM A;  2ZBM A;  4FBW A;  4TUI A;  3H63 A;  4KKZ A;  5B8I A;  1OI8 A;  3EGG A;  3ICF A;  2IE4 C;  3T1I A;  3QFM A;  4B2O A;  3H66 A;  4Q7F A;  1S3M A;  4ORC A;  4JA9 A;  4O43 A;  3RL3 A;  5JJT A;  1V73 A;  1QFC A;  3H68 A;  4LTY A;  2HYP A;  4ZVZ A;  2JOG A;  4J6O A;  1TCO A;  4UT2 A;  3DSC A;  2NYL C;  3RL5 A;  3DSD A;  2GJU A;  2NXF A;  1HP1 A;  3GVE A;  3V4Y A;  3TGH A;  2O8A A;  4H1Y P;  3E7A A;  3AV0 A;  3EGH A;  2QFP A;  4O5G A;  3H64 A;  1G5B A;  2USH A;  3IVE A;  3DW8 C;  4KBP A;  5F3W A;  4ORB A;  5INB A;  3IVD A;  2ZOA A;  2WDD A;  2DXN A;  4H2I A;  3RL4 A;  1USH A;  4DSY A;  1WAO 1;  4V0V A;  1T70 A;  3H61 A;  5GTU A;  1KBP A;  4H2F A;  2ZO9 B;  1UF3 A;  3HVQ A;  4H2G A;  1Z2W A;  3E0J A;  4G9J A;  3PSN A;  2A22 A;  1Z2X A;  3JYF A;  4UT3 B;  1JK7 A;  5HPE A;  3H69 A;  1OIE A;  3THO B;  3N5U A;  2XMO A;  4LU9 A;  2BCD A;  1XM7 A;  4O4K A;  1SU1 A;  3K7V C;  5IOH A;  1OID A;  4MOY A;  1U32 A;  3H62 B;  3QG5 C;  2QFR A;  3H60 A;  1XZW A;  4V0X A;  4TUG A;  1W24 A;  2YVT A;  4FBK A;  4DHL A;  4YKE A;  5DNY A;  4HD0 A;  3THN A;  3C5W C;  2CV9 A;  4MOV A;  2NPP C;  3QFK A;  5EQV A;  4O24 A;  2AHD A;  5J28 A;  2DXL A;  1WAR A;  1MF8 A;  2P6B A;  3FLO A;  4JA7 A;  3ZTV A;  5JPF A;  2HYO A;  1HPU A;  2YEQ A;  1S8E A;  4H1S A;  3ZU0 A;  3KBP A;  1S3N A;  2Z06 A;  3E7B A;  3IB8 A;  3C9F A;  3K7W C;  1T71 A;  3LL8 A;  4I5L C;  1UTE A;  4XPN A;  5C1V A;  3P71 C;  3QFN A;  4FCX A;  1S95 A;  2WDC A;  3CK2 A;  1HO5 A;  3H67 A;  2DFJ A;  4OR9 A;  2Z72 A;  1IT6 A;  3QFO A;  1AUI A;  4NZV A;  2NYM C;  2BQ8 X;  1S3L A;  4LAC C;  2HY1 A;  1M63 A;  3RQZ A;  4WWL A;  2R17 A;  4FBQ A;  4ZX2 A;  2KKN A;  2O8G A;  1S70 A;  5JPE A;  4H2B A;  1QHW A;  4MP0 A;  4IYP C;  2BDX A;  2WDE A;  1II7 A;  2QJC A;  4I5N C;  4ORA A;  4IL1 A;  4V0W A;  2IE3 C;  4M0V A;  3AUZ A;  4UT3 A;  3FGA C;  2IAE C;  4DT2 A;  2Q8U A;  2Z1A A;  4UWQ A;  3D03 A;  2WDF A;  3IB7 A;  4F0Z A;  1NNW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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