2R17A

Functional architecture of the retromer cargo-recognition complex
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
183
structure length
183
Chain Sequence
MMLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein transport
molecule keywords Vacuolar protein sorting-associated protein 29
publication title Functional architecture of the retromer cargo-recognition complex.
pubmed doi rcsb
source organism Homo sapiens
total genus 41
structure length 183
sequence length 183
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-08-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF12850 Metallophos_2 Calcineurin-like phosphoesterase superfamily domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 2r17A00
2IE3C 5C1VA 5B8IA 4MOVA 1TCOA 1MF8A 2A22A 1WAO1 4ORAA 4O5GA 2GJUA 4XPNA 2IE4C 3H60A 1V73A 5IOHA 2BQ8X 4LTYA 1FJMA 5EQVA 2WDCA 1W24A 1HP1A 2P6BA 3AUZA 3V4YA 3RL5A 1II7A 2CV9A 2YVTA 2KKNA 2Q8UA 4FBWA 1HO5A 3THOB 1IT6A 2HY1A 3IB8A 4O4KA 1JK7A 4ZVZA 4DSYA 3IVEA 2XMOA 3FGAC 1OIEA 3JYFA 3QFMA 1QFCA 3P71C 4M0VA 4H2IA 4O43A 3DSDA 1XM7A 4KKZA 2IAEC 5HPEA 3H68A 3H67A 2WDDA 3H63A 4MOYA 1WARA 1SU1A 2O8GA 3ZTVA 5INBA 3H61A 5F3WA 3EGHA 1M63A 1NNWA 3C9FA 4FBKA 1QHWA 1U32A 4O24A 4JA7A 4OR9A 2QJCA 3IB7A 3CK2A 4UT2A 4TUGA 2DFJA 3QFOA 4FBQA 3E7BA 4V0VA 2WDEA 3RL4A 2NYMC 4KBPA 1S95A 4HD0A 2HYOA 4JA9A 4B2OA 4J6OA 4F0ZA 5JJTA 4LU9A 4IYPC 3RL3A 4Q7FA 4UWQA 3DW8C 4ORCA 2BCDA 1Z2XA 2R17A 3H64A 4H2FA 3KBPA 1S70A 1AUIA 2USHA 1OIDA 1XZWA 3C5WC 3E7AA 3ICFA 3H62B 2NXFA 4LACC 2BDXA 3H69A 2Z1AA 2Z72A 4I5NC 1UTEA 3K7VC 1S3MA 2QFRA 3AV0A 3THNA 3QFNA 3LL8A 3H66A 5J28A 4MP0A 5JPFA 1OI8A 2AHDA 2O8AA 5JPEA 1UF3A 3QG5C 4YKEA 5DNYA 1KBPA 1S3NA 4IL1A 3TGHA 1USHA 4H1YP 4DHLA 4FCXA 3GVEA 2JOGA 4ORBA 1HPUA 4UT3B 2WDFA 3ZU0A 4H2BA 2QFPA 2ZBMA 3QFKA 5GTUA 3RQZA 1T70A 3IVDA 1G5BA 4TUIA 2NYLC 4H1SA 4DT2A 2NPPC 3EGGA 4G9JA 1S3LA 1T71A 4NZVA 4I5LC 4WWLA 4V0WA 3K7WC 4H2GA 2HYPA 1S8EA 4UT3A 3HVQA 3N5UA 3T1IA 4ZX2A 1Z2WA 3PSNA 2Z06A 3DSCA 4V0XA 3PSOA
chains in the Genus database with same CATH superfamily
2IE3C 5C1VA 5B8IA 4MOVA 1TCOA 1MF8A 2A22A 1WAO1 4ORAA 4O5GA 2GJUA 4XPNA 2IE4C 3H60A 1V73A 5IOHA 2BQ8X 4LTYA 1FJMA 5EQVA 2WDCA 1W24A 1HP1A 2P6BA 2YEQA 3AUZA 3V4YA 3RL5A 1II7A 2CV9A 2YVTA 2KKNA 2Q8UA 4FBWA 1HO5A 3THOB 1IT6A 2HY1A 3IB8A 4O4KA 1JK7A 2ZO9B 4ZVZA 4DSYA 3IVEA 2XMOA 3FGAC 1OIEA 3JYFA 3QFMA 1QFCA 3P71C 4M0VA 4H2IA 4O43A 3DSDA 1XM7A 4KKZA 2IAEC 5HPEA 3H68A 3D03A 2WDDA 3H63A 3H67A 4MOYA 1WARA 1SU1A 2O8GA 3ZTVA 5INBA 3H61A 5F3WA 3EGHA 1M63A 1NNWA 3C9FA 4FBKA 1QHWA 1U32A 4O24A 4JA7A 4OR9A 2QJCA 3IB7A 3CK2A 4UT2A 4TUGA 2DFJA 3QFOA 4FBQA 3E7BA 4V0VA 2WDEA 3RL4A 2NYMC 4KBPA 1S95A 4HD0A 2HYOA 4JA9A 4B2OA 3E0JA 4J6OA 4F0ZA 5JJTA 4LU9A 4IYPC 3RL3A 4Q7FA 4UWQA 3DW8C 4ORCA 2BCDA 1Z2XA 2R17A 3H64A 4H2FA 3KBPA 1S70A 1AUIA 2USHA 1OIDA 1XZWA 3C5WC 3E7AA 3ICFA 3H62B 2NXFA 4LACC 2BDXA 3H69A 2Z1AA 2Z72A 4I5NC 1UTEA 3K7VC 1S3MA 2QFRA 3AV0A 3THNA 3QFNA 3LL8A 3H66A 5J28A 4MP0A 5JPFA 1OI8A 2AHDA 2DXLA 2O8AA 5JPEA 1UF3A 3QG5C 3FLOA 4YKEA 1KBPA 1S3NA 4IL1A 3TGHA 5DNYA 1USHA 4H1YP 4DHLA 4FCXA 3GVEA 2JOGA 4ORBA 1HPUA 4UT3B 2WDFA 3ZU0A 4H2BA 2QFPA 2ZBMA 3QFKA 5GTUA 3RQZA 1T70A 3IVDA 1G5BA 4TUIA 2NYLC 2ZOAA 4H1SA 4DT2A 2NPPC 3EGGA 4G9JA 1S3LA 1T71A 4NZVA 4I5LC 2DXNA 4WWLA 4V0WA 3K7WC 4H2GA 2HYPA 1S8EA 4UT3A 3HVQA 3N5UA 3T1IA 4ZX2A 1Z2WA 3PSNA 2Z06A 3DSCA 4V0XA 3PSOA
chains in the Genus database with same CATH topology
2IE3C 5C1VA 5B8IA 4MOVA 1TCOA 1MF8A 2A22A 1WAO1 4ORAA 4O5GA 2GJUA 4XPNA 2IE4C 3H60A 1V73A 5IOHA 2BQ8X 4LTYA 1FJMA 5EQVA 2WDCA 1W24A 1HP1A 2P6BA 2YEQA 3AUZA 3V4YA 3RL5A 1II7A 2CV9A 2YVTA 2KKNA 2Q8UA 4FBWA 1HO5A 3THOB 1IT6A 2HY1A 3IB8A 4O4KA 1JK7A 2ZO9B 4ZVZA 4DSYA 3IVEA 2XMOA 3FGAC 1OIEA 3JYFA 3QFMA 1QFCA 3P71C 4M0VA 4H2IA 4O43A 3DSDA 1XM7A 4KKZA 2IAEC 5HPEA 3H68A 3D03A 2WDDA 3H63A 3H67A 4MOYA 1WARA 1SU1A 2O8GA 3ZTVA 5INBA 3H61A 5F3WA 3EGHA 1M63A 1NNWA 3C9FA 4FBKA 1QHWA 1U32A 4O24A 4JA7A 4OR9A 2QJCA 3IB7A 3CK2A 4UT2A 4TUGA 2DFJA 3QFOA 4FBQA 3E7BA 4V0VA 2WDEA 3RL4A 2NYMC 4KBPA 1S95A 4HD0A 2HYOA 4JA9A 4B2OA 3E0JA 4J6OA 4F0ZA 5JJTA 4LU9A 4IYPC 3RL3A 4Q7FA 4UWQA 3DW8C 4ORCA 2BCDA 1Z2XA 2R17A 3H64A 4H2FA 3KBPA 1S70A 1AUIA 2USHA 1OIDA 1XZWA 3C5WC 3E7AA 3ICFA 3H62B 2NXFA 4LACC 2BDXA 3H69A 2Z1AA 2Z72A 4I5NC 1UTEA 3K7VC 1S3MA 2QFRA 3AV0A 3THNA 3QFNA 3LL8A 3H66A 5J28A 4MP0A 5JPFA 1OI8A 2AHDA 2DXLA 2O8AA 5JPEA 1UF3A 3QG5C 3FLOA 4YKEA 1KBPA 1S3NA 4IL1A 3TGHA 5DNYA 1USHA 4H1YP 4DHLA 4FCXA 3GVEA 2JOGA 4ORBA 1HPUA 4UT3B 2WDFA 3ZU0A 4H2BA 2QFPA 2ZBMA 3QFKA 5GTUA 3RQZA 1T70A 3IVDA 1G5BA 4TUIA 2NYLC 2ZOAA 4H1SA 4DT2A 2NPPC 3EGGA 4G9JA 1S3LA 1T71A 4NZVA 4I5LC 2DXNA 4WWLA 4V0WA 3K7WC 4H2GA 2HYPA 1S8EA 4UT3A 3HVQA 3N5UA 3T1IA 4ZX2A 1Z2WA 3PSNA 2Z06A 3DSCA 4V0XA 3PSOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2IE3 C;  5C1V A;  5B8I A;  4MOV A;  1TCO A;  1MF8 A;  2A22 A;  1WAO 1;  4ORA A;  4O5G A;  2GJU A;  4XPN A;  2IE4 C;  3H60 A;  1V73 A;  5IOH A;  2BQ8 X;  4LTY A;  1FJM A;  5EQV A;  2WDC A;  1W24 A;  1HP1 A;  2P6B A;  3AUZ A;  3V4Y A;  3RL5 A;  1II7 A;  2CV9 A;  2YVT A;  2KKN A;  2Q8U A;  4FBW A;  1HO5 A;  3THO B;  1IT6 A;  2HY1 A;  3IB8 A;  4O4K A;  1JK7 A;  4ZVZ A;  4DSY A;  3IVE A;  2XMO A;  3FGA C;  1OIE A;  3JYF A;  3QFM A;  1QFC A;  3P71 C;  4M0V A;  4H2I A;  4O43 A;  3DSD A;  1XM7 A;  4KKZ A;  2IAE C;  5HPE A;  3H68 A;  3H67 A;  2WDD A;  3H63 A;  4MOY A;  1WAR A;  1SU1 A;  2O8G A;  3ZTV A;  5INB A;  3H61 A;  5F3W A;  3EGH A;  1M63 A;  1NNW A;  3C9F A;  4FBK A;  1QHW A;  1U32 A;  4O24 A;  4JA7 A;  4OR9 A;  2QJC A;  3IB7 A;  3CK2 A;  4UT2 A;  4TUG A;  2DFJ A;  3QFO A;  4FBQ A;  3E7B A;  4V0V A;  2WDE A;  3RL4 A;  2NYM C;  4KBP A;  1S95 A;  4HD0 A;  2HYO A;  4JA9 A;  4B2O A;  4J6O A;  4F0Z A;  5JJT A;  4LU9 A;  4IYP C;  3RL3 A;  4Q7F A;  4UWQ A;  3DW8 C;  4ORC A;  2BCD A;  1Z2X A;  2R17 A;  3H64 A;  4H2F A;  3KBP A;  1S70 A;  1AUI A;  2USH A;  1OID A;  1XZW A;  3C5W C;  3E7A A;  3ICF A;  3H62 B;  2NXF A;  4LAC C;  2BDX A;  3H69 A;  2Z1A A;  2Z72 A;  4I5N C;  1UTE A;  3K7V C;  1S3M A;  2QFR A;  3AV0 A;  3THN A;  3QFN A;  3LL8 A;  3H66 A;  5J28 A;  4MP0 A;  5JPF A;  1OI8 A;  2AHD A;  2O8A A;  5JPE A;  1UF3 A;  3QG5 C;  4YKE A;  5DNY A;  1KBP A;  1S3N A;  4IL1 A;  3TGH A;  1USH A;  4H1Y P;  4DHL A;  4FCX A;  3GVE A;  2JOG A;  4ORB A;  1HPU A;  4UT3 B;  2WDF A;  3ZU0 A;  4H2B A;  2QFP A;  2ZBM A;  3QFK A;  5GTU A;  3RQZ A;  1T70 A;  3IVD A;  1G5B A;  4TUI A;  2NYL C;  4H1S A;  4DT2 A;  2NPP C;  3EGG A;  4G9J A;  1S3L A;  1T71 A;  4NZV A;  4I5L C;  4WWL A;  4V0W A;  3K7W C;  4H2G A;  2HYP A;  1S8E A;  4UT3 A;  3HVQ A;  3N5U A;  3T1I A;  4ZX2 A;  1Z2W A;  3PSN A;  2Z06 A;  3DSC A;  4V0X A;  3PSO A; 
#chains in the Genus database with same CATH topology
 2IE3 C;  5C1V A;  5B8I A;  4MOV A;  1TCO A;  1MF8 A;  2A22 A;  1WAO 1;  4ORA A;  4O5G A;  2GJU A;  4XPN A;  2IE4 C;  3H60 A;  1V73 A;  5IOH A;  2BQ8 X;  4LTY A;  1FJM A;  5EQV A;  2WDC A;  1W24 A;  1HP1 A;  2P6B A;  2YEQ A;  3AUZ A;  3V4Y A;  3RL5 A;  1II7 A;  2CV9 A;  2YVT A;  2KKN A;  2Q8U A;  4FBW A;  1HO5 A;  3THO B;  1IT6 A;  2HY1 A;  3IB8 A;  4O4K A;  1JK7 A;  2ZO9 B;  4ZVZ A;  4DSY A;  3IVE A;  2XMO A;  3FGA C;  1OIE A;  3JYF A;  3QFM A;  1QFC A;  3P71 C;  4M0V A;  4H2I A;  4O43 A;  3DSD A;  1XM7 A;  4KKZ A;  2IAE C;  5HPE A;  3H68 A;  3D03 A;  2WDD A;  3H63 A;  3H67 A;  4MOY A;  1WAR A;  1SU1 A;  2O8G A;  3ZTV A;  5INB A;  3H61 A;  5F3W A;  3EGH A;  1M63 A;  1NNW A;  3C9F A;  4FBK A;  1QHW A;  1U32 A;  4O24 A;  4JA7 A;  4OR9 A;  2QJC A;  3IB7 A;  3CK2 A;  4UT2 A;  4TUG A;  2DFJ A;  3QFO A;  4FBQ A;  3E7B A;  4V0V A;  2WDE A;  3RL4 A;  2NYM C;  4KBP A;  1S95 A;  4HD0 A;  2HYO A;  4JA9 A;  4B2O A;  3E0J A;  4J6O A;  4F0Z A;  5JJT A;  4LU9 A;  4IYP C;  3RL3 A;  4Q7F A;  4UWQ A;  3DW8 C;  4ORC A;  2BCD A;  1Z2X A;  2R17 A;  3H64 A;  4H2F A;  3KBP A;  1S70 A;  1AUI A;  2USH A;  1OID A;  1XZW A;  3C5W C;  3E7A A;  3ICF A;  3H62 B;  2NXF A;  4LAC C;  2BDX A;  3H69 A;  2Z1A A;  2Z72 A;  4I5N C;  1UTE A;  3K7V C;  1S3M A;  2QFR A;  3AV0 A;  3THN A;  3QFN A;  3LL8 A;  3H66 A;  5J28 A;  4MP0 A;  5JPF A;  1OI8 A;  2AHD A;  2DXL A;  2O8A A;  5JPE A;  1UF3 A;  3QG5 C;  3FLO A;  4YKE A;  1KBP A;  1S3N A;  4IL1 A;  3TGH A;  5DNY A;  1USH A;  4H1Y P;  4DHL A;  4FCX A;  3GVE A;  2JOG A;  4ORB A;  1HPU A;  4UT3 B;  2WDF A;  3ZU0 A;  4H2B A;  2QFP A;  2ZBM A;  3QFK A;  5GTU A;  3RQZ A;  1T70 A;  3IVD A;  1G5B A;  4TUI A;  2NYL C;  2ZOA A;  4H1S A;  4DT2 A;  2NPP C;  3EGG A;  4G9J A;  1S3L A;  1T71 A;  4NZV A;  4I5L C;  2DXN A;  4WWL A;  4V0W A;  3K7W C;  4H2G A;  2HYP A;  1S8E A;  4UT3 A;  3HVQ A;  3N5U A;  3T1I A;  4ZX2 A;  1Z2W A;  3PSN A;  2Z06 A;  3DSC A;  4V0X A;  3PSO A; 
#chains in the Genus database with same CATH homology
 2IE3 C;  5C1V A;  5B8I A;  4MOV A;  1TCO A;  1MF8 A;  2A22 A;  1WAO 1;  4ORA A;  4O5G A;  2GJU A;  4XPN A;  2IE4 C;  3H60 A;  1V73 A;  5IOH A;  2BQ8 X;  4LTY A;  1FJM A;  5EQV A;  2WDC A;  1W24 A;  1HP1 A;  2P6B A;  2YEQ A;  3AUZ A;  3V4Y A;  3RL5 A;  1II7 A;  2CV9 A;  2YVT A;  2KKN A;  2Q8U A;  4FBW A;  1HO5 A;  3THO B;  1IT6 A;  2HY1 A;  3IB8 A;  4O4K A;  1JK7 A;  2ZO9 B;  4ZVZ A;  4DSY A;  3IVE A;  2XMO A;  3FGA C;  1OIE A;  3JYF A;  3QFM A;  1QFC A;  3P71 C;  4M0V A;  4H2I A;  4O43 A;  3DSD A;  1XM7 A;  4KKZ A;  2IAE C;  5HPE A;  3H68 A;  3D03 A;  2WDD A;  3H63 A;  3H67 A;  4MOY A;  1WAR A;  1SU1 A;  2O8G A;  3ZTV A;  5INB A;  3H61 A;  5F3W A;  3EGH A;  1M63 A;  1NNW A;  3C9F A;  4FBK A;  1QHW A;  1U32 A;  4O24 A;  4JA7 A;  4OR9 A;  2QJC A;  3IB7 A;  3CK2 A;  4UT2 A;  4TUG A;  2DFJ A;  3QFO A;  4FBQ A;  3E7B A;  4V0V A;  2WDE A;  3RL4 A;  2NYM C;  4KBP A;  1S95 A;  4HD0 A;  2HYO A;  4JA9 A;  4B2O A;  3E0J A;  4J6O A;  4F0Z A;  5JJT A;  4LU9 A;  4IYP C;  3RL3 A;  4Q7F A;  4UWQ A;  3DW8 C;  4ORC A;  2BCD A;  1Z2X A;  2R17 A;  3H64 A;  4H2F A;  3KBP A;  1S70 A;  1AUI A;  2USH A;  1OID A;  1XZW A;  3C5W C;  3E7A A;  3ICF A;  3H62 B;  2NXF A;  4LAC C;  2BDX A;  3H69 A;  2Z1A A;  2Z72 A;  4I5N C;  1UTE A;  3K7V C;  1S3M A;  2QFR A;  3AV0 A;  3THN A;  3QFN A;  3LL8 A;  3H66 A;  5J28 A;  4MP0 A;  5JPF A;  1OI8 A;  2AHD A;  2DXL A;  2O8A A;  5JPE A;  1UF3 A;  3QG5 C;  3FLO A;  4YKE A;  1KBP A;  1S3N A;  4IL1 A;  3TGH A;  5DNY A;  1USH A;  4H1Y P;  4DHL A;  4FCX A;  3GVE A;  2JOG A;  4ORB A;  1HPU A;  4UT3 B;  2WDF A;  3ZU0 A;  4H2B A;  2QFP A;  2ZBM A;  3QFK A;  5GTU A;  3RQZ A;  1T70 A;  3IVD A;  1G5B A;  4TUI A;  2NYL C;  2ZOA A;  4H1S A;  4DT2 A;  2NPP C;  3EGG A;  4G9J A;  1S3L A;  1T71 A;  4NZV A;  4I5L C;  2DXN A;  4WWL A;  4V0W A;  3K7W C;  4H2G A;  2HYP A;  1S8E A;  4UT3 A;  3HVQ A;  3N5U A;  3T1I A;  4ZX2 A;  1Z2W A;  3PSN A;  2Z06 A;  3DSC A;  4V0X A;  3PSO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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