1WARA

Recombinant human purple acid phosphatase expressed in pichia pastoris
Total Genus 109
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
109
sequence length
310
structure length
310
Chain Sequence
EAEAEFATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADFILSLGDNFYFTGVQDINDKRFQETFEDVFSDRSLRKVPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSDDFLSQQPERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHGPTHCLVKQLRPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSKRHQRKVPNGYLRFHYGTEDSLGGFAYVEISSKEMTVTYIEASGKSLFKTRLPRRARP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of Recombinant Human Purple Acid Phosphatase with and without an Inhibitory Conformation of the Repression Loop.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords HUMAN PURPLE ACID PHOSPHATASE
total genus 109
structure length 310
sequence length 310
ec nomenclature ec 3.1.3.2: Acid phosphatase.
pdb deposition date 2004-10-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00149 Metallophos Calcineurin-like phosphoesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 1warA00
1OIDA 5B8IA 1TCOA 3PSNA 2WDCA 4ZVZA 1S70A 1HP1A 4FBWA 3V4YA 3K7VC 3DSCA 5GTUA 2BCDA 4MOVA 1HPUA 3JYFA 5JPFA 3H61A 2BQ8X 2GJUA 3E7AA 4M0VA 3IVEA 1JK7A 4DSYA 1Z2XA 2CV9A 5HPEA 2HY1A 4V0WA 3QFOA 1SU1A 3LL8A 4JA7A 2USHA 1KBPA 2NPPC 2IAEC 1NNWA 2NYMC 3C5WC 4KKZA 2R17A 1S3MA 4H1SA 3THOB 1XM7A 4MOYA 3N5UA 1U32A 1QFCA 3THNA 4TUIA 3QFKA 3QFNA 4IYPC 4KBPA 3IVDA 4H2IA 3RQZA 5IOHA 2WDFA 3H60A 4I5NC 4YKEA 1OIEA 5JJTA 3RL5A 3CK2A 3ICFA 3T1IA 1QHWA 1XZWA 3H69A 4J6OA 3IB8A 5EQVA 1II7A 2P6BA 4HD0A 4O43A 1T70A 2WDDA 4O4KA 3QG5C 2ZBMA 3H68A 2NXFA 3K7WC 4IL1A 4G9JA 1W24A 3H62B 3PSOA 3H64A 1AUIA 2DFJA 2Z72A 1IT6A 1S95A 1UTEA 1S3NA 3DSDA 1WAO1 1Z2WA 4TUGA 3RL3A 4DHLA 4F0ZA 3HVQA 3DW8C 4LTYA 4O5GA 4V0VA 3AUZA 3QFMA 4ORCA 4MP0A 4V0XA 1S8EA 2YVTA 2KKNA 3EGGA 1WARA 2AHDA 2QFRA 3KBPA 3E7BA 2Z1AA 3ZTVA 1G5BA 2A22A 3GVEA 4H2FA 1FJMA 4B2OA 4ORAA 1UF3A 1T71A 5J28A 4UT2A 2QFPA 4DT2A 4H2GA 4WWLA 2Z06A 4LACC 1OI8A 3RL4A 3AV0A 4UT3B 4H2BA 5C1VA 2WDEA 1V73A 2JOGA 2Q8UA 4UWQA 4ORBA 2XMOA 4O24A 1USHA 2HYPA 3TGHA 3EGHA 4FBQA 3IB7A 3FGAC 3H63A 4FCXA 4FBKA 2BDXA 4ZX2A 2IE3C 5INBA 4I5LC 4LU9A 2IE4C 1M63A 2HYOA 2O8GA 1HO5A 4H1YP 2NYLC 2O8AA 3P71C 3C9FA 3H67A 5DNYA 5JPEA 3ZU0A 4XPNA 5F3WA 4OR9A 1S3LA 2QJCA 3H66A 4JA9A 4Q7FA 4UT3A 1MF8A 4NZVA
chains in the Genus database with same CATH superfamily
1OIDA 5B8IA 1TCOA 3PSNA 2WDCA 4ZVZA 1S70A 1HP1A 4FBWA 3V4YA 3K7VC 3DSCA 5GTUA 2BCDA 4MOVA 1HPUA 3JYFA 5JPFA 3H61A 2BQ8X 2GJUA 3E7AA 4M0VA 3IVEA 1JK7A 4DSYA 1Z2XA 2CV9A 5HPEA 2HY1A 4V0WA 3QFOA 1SU1A 3LL8A 4JA7A 2USHA 1KBPA 2NPPC 2IAEC 1NNWA 2NYMC 3C5WC 4KKZA 2R17A 1S3MA 4H1SA 3THOB 1XM7A 4MOYA 3N5UA 1U32A 1QFCA 3THNA 4TUIA 3QFKA 3QFNA 4IYPC 4KBPA 3IVDA 4H2IA 3RQZA 5IOHA 2WDFA 3H60A 4I5NC 4YKEA 1OIEA 5JJTA 3RL5A 3CK2A 3ICFA 3T1IA 1QHWA 1XZWA 3H69A 3FLOA 4J6OA 3IB8A 5EQVA 1II7A 2P6BA 4HD0A 4O43A 1T70A 2WDDA 4O4KA 3QG5C 2DXNA 2ZBMA 3H68A 2NXFA 3K7WC 2ZOAA 4IL1A 4G9JA 1W24A 3H62B 3PSOA 3H64A 1AUIA 2DFJA 2Z72A 1IT6A 1S95A 1UTEA 1S3NA 3DSDA 1WAO1 1Z2WA 4TUGA 3RL3A 4DHLA 4F0ZA 3HVQA 3DW8C 4LTYA 4O5GA 4V0VA 3AUZA 3QFMA 4ORCA 4MP0A 4V0XA 1S8EA 2YVTA 2KKNA 3EGGA 1WARA 2AHDA 2QFRA 3KBPA 3E0JA 3E7BA 2Z1AA 2YEQA 3ZTVA 1G5BA 2A22A 3GVEA 4H2FA 1FJMA 4B2OA 4ORAA 1UF3A 1T71A 5J28A 4UT2A 2QFPA 4DT2A 4H2GA 4WWLA 2Z06A 4LACC 1OI8A 3RL4A 3AV0A 4UT3B 4H2BA 5C1VA 2WDEA 1V73A 2JOGA 2Q8UA 4UWQA 4ORBA 2XMOA 4O24A 1USHA 2HYPA 3TGHA 3EGHA 4FBQA 3IB7A 3FGAC 3H63A 4FCXA 4FBKA 2DXLA 2BDXA 4ZX2A 2IE3C 2ZO9B 5INBA 4I5LC 4LU9A 2IE4C 1M63A 2HYOA 2O8GA 1HO5A 4H1YP 2NYLC 2O8AA 3D03A 3P71C 3C9FA 3H67A 5DNYA 5JPEA 3ZU0A 4XPNA 5F3WA 4OR9A 1S3LA 2QJCA 3H66A 4JA9A 4Q7FA 4UT3A 1MF8A 4NZVA
chains in the Genus database with same CATH topology
1OIDA 5B8IA 1TCOA 3PSNA 2WDCA 4ZVZA 1S70A 1HP1A 4FBWA 3V4YA 3K7VC 3DSCA 5GTUA 2BCDA 4MOVA 1HPUA 3JYFA 5JPFA 3H61A 2BQ8X 2GJUA 3E7AA 4M0VA 3IVEA 1JK7A 4DSYA 1Z2XA 2CV9A 5HPEA 2HY1A 4V0WA 3QFOA 1SU1A 3LL8A 4JA7A 2USHA 1KBPA 2NPPC 2IAEC 1NNWA 2NYMC 3C5WC 4KKZA 2R17A 1S3MA 4H1SA 3THOB 1XM7A 4MOYA 3N5UA 1U32A 1QFCA 3THNA 4TUIA 3QFKA 3QFNA 4IYPC 4KBPA 3IVDA 4H2IA 3RQZA 5IOHA 2WDFA 3H60A 4I5NC 4YKEA 1OIEA 5JJTA 3RL5A 3CK2A 3ICFA 3T1IA 1QHWA 1XZWA 3H69A 3FLOA 4J6OA 3IB8A 5EQVA 1II7A 2P6BA 4HD0A 4O43A 1T70A 2WDDA 4O4KA 3QG5C 2DXNA 2ZBMA 3H68A 2NXFA 3K7WC 2ZOAA 4IL1A 4G9JA 1W24A 3H62B 3PSOA 3H64A 1AUIA 2DFJA 2Z72A 1IT6A 1S95A 1UTEA 1S3NA 3DSDA 1WAO1 1Z2WA 4TUGA 3RL3A 4DHLA 4F0ZA 3HVQA 3DW8C 4LTYA 4O5GA 4V0VA 3AUZA 3QFMA 4ORCA 4MP0A 4V0XA 1S8EA 2YVTA 2KKNA 3EGGA 1WARA 2AHDA 2QFRA 3KBPA 3E0JA 3E7BA 2Z1AA 2YEQA 3ZTVA 1G5BA 2A22A 3GVEA 4H2FA 1FJMA 4B2OA 4ORAA 1UF3A 1T71A 5J28A 4UT2A 2QFPA 4DT2A 4H2GA 4WWLA 2Z06A 4LACC 1OI8A 3RL4A 3AV0A 4UT3B 4H2BA 5C1VA 2WDEA 1V73A 2JOGA 2Q8UA 4UWQA 4ORBA 2XMOA 4O24A 1USHA 2HYPA 3TGHA 3EGHA 4FBQA 3IB7A 3FGAC 3H63A 4FCXA 4FBKA 2DXLA 2BDXA 4ZX2A 2IE3C 2ZO9B 5INBA 4I5LC 4LU9A 2IE4C 1M63A 2HYOA 2O8GA 1HO5A 4H1YP 2NYLC 2O8AA 3D03A 3P71C 3C9FA 3H67A 5DNYA 5JPEA 3ZU0A 4XPNA 5F3WA 4OR9A 1S3LA 2QJCA 3H66A 4JA9A 4Q7FA 4UT3A 1MF8A 4NZVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1OID A;  5B8I A;  1TCO A;  3PSN A;  2WDC A;  4ZVZ A;  1S70 A;  1HP1 A;  4FBW A;  3V4Y A;  3K7V C;  3DSC A;  5GTU A;  2BCD A;  4MOV A;  1HPU A;  3JYF A;  5JPF A;  3H61 A;  2BQ8 X;  2GJU A;  3E7A A;  4M0V A;  3IVE A;  1JK7 A;  4DSY A;  1Z2X A;  2CV9 A;  5HPE A;  2HY1 A;  4V0W A;  3QFO A;  1SU1 A;  3LL8 A;  4JA7 A;  2USH A;  1KBP A;  2NPP C;  2IAE C;  1NNW A;  2NYM C;  3C5W C;  4KKZ A;  2R17 A;  1S3M A;  4H1S A;  3THO B;  1XM7 A;  4MOY A;  3N5U A;  1U32 A;  1QFC A;  3THN A;  4TUI A;  3QFK A;  3QFN A;  4IYP C;  4KBP A;  3IVD A;  4H2I A;  3RQZ A;  5IOH A;  2WDF A;  3H60 A;  4I5N C;  4YKE A;  1OIE A;  5JJT A;  3RL5 A;  3CK2 A;  3ICF A;  3T1I A;  1QHW A;  1XZW A;  3H69 A;  4J6O A;  3IB8 A;  5EQV A;  1II7 A;  2P6B A;  4HD0 A;  4O43 A;  1T70 A;  2WDD A;  4O4K A;  3QG5 C;  2ZBM A;  3H68 A;  2NXF A;  3K7W C;  4IL1 A;  4G9J A;  1W24 A;  3H62 B;  3PSO A;  3H64 A;  1AUI A;  2DFJ A;  2Z72 A;  1IT6 A;  1S95 A;  1UTE A;  1S3N A;  3DSD A;  1WAO 1;  1Z2W A;  4TUG A;  3RL3 A;  4DHL A;  4F0Z A;  3HVQ A;  3DW8 C;  4LTY A;  4O5G A;  4V0V A;  3AUZ A;  3QFM A;  4ORC A;  4MP0 A;  4V0X A;  1S8E A;  2YVT A;  2KKN A;  3EGG A;  1WAR A;  2AHD A;  2QFR A;  3KBP A;  3E7B A;  2Z1A A;  3ZTV A;  1G5B A;  2A22 A;  3GVE A;  4H2F A;  1FJM A;  4B2O A;  4ORA A;  1UF3 A;  1T71 A;  5J28 A;  4UT2 A;  2QFP A;  4DT2 A;  4H2G A;  4WWL A;  2Z06 A;  4LAC C;  1OI8 A;  3RL4 A;  3AV0 A;  4UT3 B;  4H2B A;  5C1V A;  2WDE A;  1V73 A;  2JOG A;  2Q8U A;  4UWQ A;  4ORB A;  2XMO A;  4O24 A;  1USH A;  2HYP A;  3TGH A;  3EGH A;  4FBQ A;  3IB7 A;  3FGA C;  3H63 A;  4FCX A;  4FBK A;  2BDX A;  4ZX2 A;  2IE3 C;  5INB A;  4I5L C;  4LU9 A;  2IE4 C;  1M63 A;  2HYO A;  2O8G A;  1HO5 A;  4H1Y P;  2NYL C;  2O8A A;  3P71 C;  3C9F A;  3H67 A;  5DNY A;  5JPE A;  3ZU0 A;  4XPN A;  5F3W A;  4OR9 A;  1S3L A;  2QJC A;  3H66 A;  4JA9 A;  4Q7F A;  4UT3 A;  1MF8 A;  4NZV A; 
#chains in the Genus database with same CATH topology
 1OID A;  5B8I A;  1TCO A;  3PSN A;  2WDC A;  4ZVZ A;  1S70 A;  1HP1 A;  4FBW A;  3V4Y A;  3K7V C;  3DSC A;  5GTU A;  2BCD A;  4MOV A;  1HPU A;  3JYF A;  5JPF A;  3H61 A;  2BQ8 X;  2GJU A;  3E7A A;  4M0V A;  3IVE A;  1JK7 A;  4DSY A;  1Z2X A;  2CV9 A;  5HPE A;  2HY1 A;  4V0W A;  3QFO A;  1SU1 A;  3LL8 A;  4JA7 A;  2USH A;  1KBP A;  2NPP C;  2IAE C;  1NNW A;  2NYM C;  3C5W C;  4KKZ A;  2R17 A;  1S3M A;  4H1S A;  3THO B;  1XM7 A;  4MOY A;  3N5U A;  1U32 A;  1QFC A;  3THN A;  4TUI A;  3QFK A;  3QFN A;  4IYP C;  4KBP A;  3IVD A;  4H2I A;  3RQZ A;  5IOH A;  2WDF A;  3H60 A;  4I5N C;  4YKE A;  1OIE A;  5JJT A;  3RL5 A;  3CK2 A;  3ICF A;  3T1I A;  1QHW A;  1XZW A;  3H69 A;  3FLO A;  4J6O A;  3IB8 A;  5EQV A;  1II7 A;  2P6B A;  4HD0 A;  4O43 A;  1T70 A;  2WDD A;  4O4K A;  3QG5 C;  2DXN A;  2ZBM A;  3H68 A;  2NXF A;  3K7W C;  2ZOA A;  4IL1 A;  4G9J A;  1W24 A;  3H62 B;  3PSO A;  3H64 A;  1AUI A;  2DFJ A;  2Z72 A;  1IT6 A;  1S95 A;  1UTE A;  1S3N A;  3DSD A;  1WAO 1;  1Z2W A;  4TUG A;  3RL3 A;  4DHL A;  4F0Z A;  3HVQ A;  3DW8 C;  4LTY A;  4O5G A;  4V0V A;  3AUZ A;  3QFM A;  4ORC A;  4MP0 A;  4V0X A;  1S8E A;  2YVT A;  2KKN A;  3EGG A;  1WAR A;  2AHD A;  2QFR A;  3KBP A;  3E0J A;  3E7B A;  2Z1A A;  2YEQ A;  3ZTV A;  1G5B A;  2A22 A;  3GVE A;  4H2F A;  1FJM A;  4B2O A;  4ORA A;  1UF3 A;  1T71 A;  5J28 A;  4UT2 A;  2QFP A;  4DT2 A;  4H2G A;  4WWL A;  2Z06 A;  4LAC C;  1OI8 A;  3RL4 A;  3AV0 A;  4UT3 B;  4H2B A;  5C1V A;  2WDE A;  1V73 A;  2JOG A;  2Q8U A;  4UWQ A;  4ORB A;  2XMO A;  4O24 A;  1USH A;  2HYP A;  3TGH A;  3EGH A;  4FBQ A;  3IB7 A;  3FGA C;  3H63 A;  4FCX A;  4FBK A;  2DXL A;  2BDX A;  4ZX2 A;  2IE3 C;  2ZO9 B;  5INB A;  4I5L C;  4LU9 A;  2IE4 C;  1M63 A;  2HYO A;  2O8G A;  1HO5 A;  4H1Y P;  2NYL C;  2O8A A;  3D03 A;  3P71 C;  3C9F A;  3H67 A;  5DNY A;  5JPE A;  3ZU0 A;  4XPN A;  5F3W A;  4OR9 A;  1S3L A;  2QJC A;  3H66 A;  4JA9 A;  4Q7F A;  4UT3 A;  1MF8 A;  4NZV A; 
#chains in the Genus database with same CATH homology
 1OID A;  5B8I A;  1TCO A;  3PSN A;  2WDC A;  4ZVZ A;  1S70 A;  1HP1 A;  4FBW A;  3V4Y A;  3K7V C;  3DSC A;  5GTU A;  2BCD A;  4MOV A;  1HPU A;  3JYF A;  5JPF A;  3H61 A;  2BQ8 X;  2GJU A;  3E7A A;  4M0V A;  3IVE A;  1JK7 A;  4DSY A;  1Z2X A;  2CV9 A;  5HPE A;  2HY1 A;  4V0W A;  3QFO A;  1SU1 A;  3LL8 A;  4JA7 A;  2USH A;  1KBP A;  2NPP C;  2IAE C;  1NNW A;  2NYM C;  3C5W C;  4KKZ A;  2R17 A;  1S3M A;  4H1S A;  3THO B;  1XM7 A;  4MOY A;  3N5U A;  1U32 A;  1QFC A;  3THN A;  4TUI A;  3QFK A;  3QFN A;  4IYP C;  4KBP A;  3IVD A;  4H2I A;  3RQZ A;  5IOH A;  2WDF A;  3H60 A;  4I5N C;  4YKE A;  1OIE A;  5JJT A;  3RL5 A;  3CK2 A;  3ICF A;  3T1I A;  1QHW A;  1XZW A;  3H69 A;  3FLO A;  4J6O A;  3IB8 A;  5EQV A;  1II7 A;  2P6B A;  4HD0 A;  4O43 A;  1T70 A;  2WDD A;  4O4K A;  3QG5 C;  2DXN A;  2ZBM A;  3H68 A;  2NXF A;  3K7W C;  2ZOA A;  4IL1 A;  4G9J A;  1W24 A;  3H62 B;  3PSO A;  3H64 A;  1AUI A;  2DFJ A;  2Z72 A;  1IT6 A;  1S95 A;  1UTE A;  1S3N A;  3DSD A;  1WAO 1;  1Z2W A;  4TUG A;  3RL3 A;  4DHL A;  4F0Z A;  3HVQ A;  3DW8 C;  4LTY A;  4O5G A;  4V0V A;  3AUZ A;  3QFM A;  4ORC A;  4MP0 A;  4V0X A;  1S8E A;  2YVT A;  2KKN A;  3EGG A;  1WAR A;  2AHD A;  2QFR A;  3KBP A;  3E0J A;  3E7B A;  2Z1A A;  2YEQ A;  3ZTV A;  1G5B A;  2A22 A;  3GVE A;  4H2F A;  1FJM A;  4B2O A;  4ORA A;  1UF3 A;  1T71 A;  5J28 A;  4UT2 A;  2QFP A;  4DT2 A;  4H2G A;  4WWL A;  2Z06 A;  4LAC C;  1OI8 A;  3RL4 A;  3AV0 A;  4UT3 B;  4H2B A;  5C1V A;  2WDE A;  1V73 A;  2JOG A;  2Q8U A;  4UWQ A;  4ORB A;  2XMO A;  4O24 A;  1USH A;  2HYP A;  3TGH A;  3EGH A;  4FBQ A;  3IB7 A;  3FGA C;  3H63 A;  4FCX A;  4FBK A;  2DXL A;  2BDX A;  4ZX2 A;  2IE3 C;  2ZO9 B;  5INB A;  4I5L C;  4LU9 A;  2IE4 C;  1M63 A;  2HYO A;  2O8G A;  1HO5 A;  4H1Y P;  2NYL C;  2O8A A;  3D03 A;  3P71 C;  3C9F A;  3H67 A;  5DNY A;  5JPE A;  3ZU0 A;  4XPN A;  5F3W A;  4OR9 A;  1S3L A;  2QJC A;  3H66 A;  4JA9 A;  4Q7F A;  4UT3 A;  1MF8 A;  4NZV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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