5GTUA

Structural and mechanistic insights into regulation of the retromer coat by tbc1d5
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
186
structure length
186
Chain Sequence
MAGHRLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and mechanistic insights into regulation of the retromer coat by TBC1d5
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords Vacuolar protein sorting-associated protein 29
total genus 49
structure length 186
sequence length 186
ec nomenclature
pdb deposition date 2016-08-23
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 5gtuA00
3QG5C 2NYLC 5JJTA 4HD0A 2QFRA 3IB8A 2YVTA 1G5BA 2Q8UA 2HY1A 3C5WC 2Z06A 3JYFA 1S95A 5GTUA 3ZTVA 4TUIA 2KKNA 3H63A 4IYPC 2IE3C 4I5LC 4DHLA 2Z72A 3ICFA 2WDCA 4ORCA 2WDEA 4LU9A 4YKEA 1OI8A 4IL1A 4Q7FA 4ZVZA 3EGHA 1QFCA 3PSNA 1WAO1 5IOHA 5INBA 4MOVA 1MF8A 3RL4A 4JA7A 4MOYA 3IVDA 4O4KA 4NZVA 3RL5A 3DSCA 1HO5A 2BDXA 4H2BA 2IE4C 3IB7A 3ZU0A 5HPEA 1S3NA 1UTEA 3E7AA 1TCOA 1V73A 3RQZA 3QFNA 3E7BA 4XPNA 3K7WC 2HYPA 4O24A 2NXFA 2O8GA 1HPUA 3H62B 2O8AA 4M0VA 3H68A 2CV9A 1II7A 1KBPA 4FBQA 4O5GA 1OIEA 4KKZA 2QFPA 4KBPA 3T1IA 4V0VA 5JPEA 3K7VC 3AUZA 4H1SA 3H61A 2USHA 1Z2WA 3N5UA 4H2GA 1AUIA 4DT2A 1XM7A 2A22A 3FGAC 4H1YP 4ORBA 5JPFA 3H67A 1T71A 1W24A 3C9FA 1FJMA 1HP1A 2BQ8X 2WDDA 4V0XA 2ZBMA 4ORAA 4V0WA 2HYOA 1QHWA 4FBKA 4LACC 4B2OA 4H2FA 3IVEA 5J28A 3QFKA 1XZWA 1Z2XA 4G9JA 2Z1AA 2JOGA 1M63A 3QFOA 3RL3A 5F3WA 4H2IA 1T70A 4TUGA 1NNWA 3AV0A 5DNYA 3P71C 3THOB 1S70A 2GJUA 3EGGA 3LL8A 2IAEC 1SU1A 1U32A 1WARA 2P6BA 4UT3A 4J6OA 1IT6A 2R17A 4LTYA 2BCDA 3PSOA 3H60A 4DSYA 2DFJA 3DSDA 3H69A 2AHDA 4OR9A 3QFMA 4ZX2A 3H64A 2NPPC 3DW8C 4F0ZA 4JA9A 1OIDA 4FBWA 3KBPA 3THNA 1S8EA 2NYMC 4O43A 2QJCA 2XMOA 4WWLA 2WDFA 4UT2A 4FCXA 3HVQA 3TGHA 1UF3A 3CK2A 1USHA 4I5NC 5EQVA 5B8IA 4UWQA 1S3LA 5C1VA 4UT3B 3V4YA 3H66A 1JK7A 3GVEA 4MP0A 1S3MA
chains in the Genus database with same CATH superfamily
3QG5C 2NYLC 5JJTA 4HD0A 2QFRA 3IB8A 2YVTA 1G5BA 2Q8UA 2HY1A 3C5WC 2Z06A 3JYFA 1S95A 5GTUA 3ZTVA 4TUIA 2KKNA 3H63A 4IYPC 2IE3C 4I5LC 4DHLA 2Z72A 3ICFA 2WDCA 4ORCA 2WDEA 4LU9A 4YKEA 1OI8A 4IL1A 4Q7FA 4ZVZA 3EGHA 1QFCA 3PSNA 1WAO1 5IOHA 5INBA 2DXLA 1MF8A 4MOVA 3RL4A 4JA7A 4MOYA 3IVDA 4O4KA 4NZVA 3RL5A 3DSCA 1HO5A 2BDXA 4H2BA 2IE4C 3IB7A 3ZU0A 5HPEA 1S3NA 1UTEA 3E7AA 1TCOA 1V73A 3RQZA 3QFNA 3E7BA 4XPNA 3K7WC 2HYPA 4O24A 2NXFA 2O8GA 1HPUA 3H62B 2O8AA 4M0VA 3H68A 2CV9A 1II7A 1KBPA 4FBQA 4O5GA 1OIEA 3E0JA 4KKZA 2QFPA 4KBPA 3T1IA 4V0VA 5JPEA 3K7VC 3AUZA 4H1SA 2ZOAA 3H61A 2USHA 1Z2WA 3N5UA 4H2GA 1AUIA 4DT2A 1XM7A 2A22A 3FGAC 4H1YP 4ORBA 5JPFA 3H67A 1T71A 1W24A 3C9FA 1FJMA 1HP1A 2BQ8X 2WDDA 4V0XA 2ZBMA 4ORAA 4V0WA 2HYOA 1QHWA 4FBKA 4LACC 4B2OA 4H2FA 3IVEA 5J28A 3QFKA 1XZWA 1Z2XA 4G9JA 2Z1AA 2JOGA 1M63A 3QFOA 3RL3A 5F3WA 4H2IA 1T70A 4TUGA 1NNWA 3AV0A 2DXNA 5DNYA 3P71C 3THOB 1S70A 2GJUA 3EGGA 3LL8A 2IAEC 3D03A 1SU1A 1U32A 1WARA 2P6BA 4UT3A 4J6OA 1IT6A 2R17A 4LTYA 2BCDA 3PSOA 3H60A 4DSYA 2DFJA 3DSDA 3H69A 2AHDA 4OR9A 3QFMA 4ZX2A 2YEQA 3H64A 2NPPC 3DW8C 4F0ZA 4JA9A 1OIDA 4FBWA 3KBPA 3THNA 1S8EA 2NYMC 2ZO9B 4O43A 2QJCA 2XMOA 4WWLA 2WDFA 4UT2A 4FCXA 3HVQA 3TGHA 1UF3A 3CK2A 1USHA 4I5NC 5EQVA 5B8IA 3FLOA 4UWQA 1S3LA 5C1VA 4UT3B 3V4YA 3H66A 1JK7A 3GVEA 4MP0A 1S3MA
chains in the Genus database with same CATH topology
3QG5C 2NYLC 5JJTA 4HD0A 2QFRA 3IB8A 2YVTA 1G5BA 2Q8UA 2HY1A 3C5WC 2Z06A 3JYFA 1S95A 5GTUA 3ZTVA 4TUIA 2KKNA 3H63A 4IYPC 2IE3C 4I5LC 4DHLA 2Z72A 3ICFA 2WDCA 4ORCA 2WDEA 4LU9A 4YKEA 1OI8A 4IL1A 4Q7FA 4ZVZA 3EGHA 1QFCA 3PSNA 1WAO1 5IOHA 5INBA 2DXLA 1MF8A 4MOVA 3RL4A 4JA7A 4MOYA 3IVDA 4O4KA 4NZVA 3RL5A 3DSCA 1HO5A 2BDXA 4H2BA 2IE4C 3IB7A 3ZU0A 5HPEA 1S3NA 1UTEA 3E7AA 1TCOA 1V73A 3RQZA 3QFNA 3E7BA 4XPNA 3K7WC 2HYPA 4O24A 2NXFA 2O8GA 1HPUA 3H62B 2O8AA 4M0VA 3H68A 2CV9A 1II7A 1KBPA 4FBQA 4O5GA 1OIEA 3E0JA 4KKZA 2QFPA 4KBPA 3T1IA 4V0VA 5JPEA 3K7VC 3AUZA 4H1SA 2ZOAA 3H61A 2USHA 1Z2WA 3N5UA 4H2GA 1AUIA 4DT2A 1XM7A 2A22A 3FGAC 4H1YP 4ORBA 5JPFA 3H67A 1T71A 1W24A 3C9FA 1FJMA 1HP1A 2BQ8X 2WDDA 4V0XA 2ZBMA 4ORAA 4V0WA 2HYOA 1QHWA 4FBKA 4LACC 4B2OA 4H2FA 3IVEA 5J28A 3QFKA 1XZWA 1Z2XA 4G9JA 2Z1AA 2JOGA 1M63A 3QFOA 3RL3A 5F3WA 4H2IA 1T70A 4TUGA 1NNWA 3AV0A 2DXNA 5DNYA 3P71C 3THOB 1S70A 2GJUA 3EGGA 3LL8A 2IAEC 3D03A 1SU1A 1U32A 1WARA 2P6BA 4UT3A 4J6OA 1IT6A 2R17A 4LTYA 2BCDA 3PSOA 3H60A 4DSYA 2DFJA 3DSDA 3H69A 2AHDA 4OR9A 3QFMA 4ZX2A 2YEQA 3H64A 2NPPC 3DW8C 4F0ZA 4JA9A 1OIDA 4FBWA 3KBPA 3THNA 1S8EA 2NYMC 2ZO9B 4O43A 2QJCA 2XMOA 4WWLA 2WDFA 4UT2A 4FCXA 3HVQA 3TGHA 1UF3A 3CK2A 1USHA 4I5NC 5EQVA 5B8IA 3FLOA 4UWQA 1S3LA 5C1VA 4UT3B 3V4YA 3H66A 1JK7A 3GVEA 4MP0A 1S3MA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QG5 C;  2NYL C;  5JJT A;  4HD0 A;  2QFR A;  3IB8 A;  2YVT A;  1G5B A;  2Q8U A;  2HY1 A;  3C5W C;  2Z06 A;  3JYF A;  1S95 A;  5GTU A;  3ZTV A;  4TUI A;  2KKN A;  3H63 A;  4IYP C;  2IE3 C;  4I5L C;  4DHL A;  2Z72 A;  3ICF A;  2WDC A;  4ORC A;  2WDE A;  4LU9 A;  4YKE A;  1OI8 A;  4IL1 A;  4Q7F A;  4ZVZ A;  3EGH A;  1QFC A;  3PSN A;  1WAO 1;  5IOH A;  5INB A;  4MOV A;  1MF8 A;  3RL4 A;  4JA7 A;  4MOY A;  3IVD A;  4O4K A;  4NZV A;  3RL5 A;  3DSC A;  1HO5 A;  2BDX A;  4H2B A;  2IE4 C;  3IB7 A;  3ZU0 A;  5HPE A;  1S3N A;  1UTE A;  3E7A A;  1TCO A;  1V73 A;  3RQZ A;  3QFN A;  3E7B A;  4XPN A;  3K7W C;  2HYP A;  4O24 A;  2NXF A;  2O8G A;  1HPU A;  3H62 B;  2O8A A;  4M0V A;  3H68 A;  2CV9 A;  1II7 A;  1KBP A;  4FBQ A;  4O5G A;  1OIE A;  4KKZ A;  2QFP A;  4KBP A;  3T1I A;  4V0V A;  5JPE A;  3K7V C;  3AUZ A;  4H1S A;  3H61 A;  2USH A;  1Z2W A;  3N5U A;  4H2G A;  1AUI A;  4DT2 A;  1XM7 A;  2A22 A;  3FGA C;  4H1Y P;  4ORB A;  5JPF A;  3H67 A;  1T71 A;  1W24 A;  3C9F A;  1FJM A;  1HP1 A;  2BQ8 X;  2WDD A;  4V0X A;  2ZBM A;  4ORA A;  4V0W A;  2HYO A;  1QHW A;  4FBK A;  4LAC C;  4B2O A;  4H2F A;  3IVE A;  5J28 A;  3QFK A;  1XZW A;  1Z2X A;  4G9J A;  2Z1A A;  2JOG A;  1M63 A;  3QFO A;  3RL3 A;  5F3W A;  4H2I A;  1T70 A;  4TUG A;  1NNW A;  3AV0 A;  5DNY A;  3P71 C;  3THO B;  1S70 A;  2GJU A;  3EGG A;  3LL8 A;  2IAE C;  1SU1 A;  1U32 A;  1WAR A;  2P6B A;  4UT3 A;  4J6O A;  1IT6 A;  2R17 A;  4LTY A;  2BCD A;  3PSO A;  3H60 A;  4DSY A;  2DFJ A;  3DSD A;  3H69 A;  2AHD A;  4OR9 A;  3QFM A;  4ZX2 A;  3H64 A;  2NPP C;  3DW8 C;  4F0Z A;  4JA9 A;  1OID A;  4FBW A;  3KBP A;  3THN A;  1S8E A;  2NYM C;  4O43 A;  2QJC A;  2XMO A;  4WWL A;  2WDF A;  4UT2 A;  4FCX A;  3HVQ A;  3TGH A;  1UF3 A;  3CK2 A;  1USH A;  4I5N C;  5EQV A;  5B8I A;  4UWQ A;  1S3L A;  5C1V A;  4UT3 B;  3V4Y A;  3H66 A;  1JK7 A;  3GVE A;  4MP0 A;  1S3M A; 
#chains in the Genus database with same CATH topology
 3QG5 C;  2NYL C;  5JJT A;  4HD0 A;  2QFR A;  3IB8 A;  2YVT A;  1G5B A;  2Q8U A;  2HY1 A;  3C5W C;  2Z06 A;  3JYF A;  1S95 A;  5GTU A;  3ZTV A;  4TUI A;  2KKN A;  3H63 A;  4IYP C;  2IE3 C;  4I5L C;  4DHL A;  2Z72 A;  3ICF A;  2WDC A;  4ORC A;  2WDE A;  4LU9 A;  4YKE A;  1OI8 A;  4IL1 A;  4Q7F A;  4ZVZ A;  3EGH A;  1QFC A;  3PSN A;  1WAO 1;  5IOH A;  5INB A;  2DXL A;  1MF8 A;  4MOV A;  3RL4 A;  4JA7 A;  4MOY A;  3IVD A;  4O4K A;  4NZV A;  3RL5 A;  3DSC A;  1HO5 A;  2BDX A;  4H2B A;  2IE4 C;  3IB7 A;  3ZU0 A;  5HPE A;  1S3N A;  1UTE A;  3E7A A;  1TCO A;  1V73 A;  3RQZ A;  3QFN A;  3E7B A;  4XPN A;  3K7W C;  2HYP A;  4O24 A;  2NXF A;  2O8G A;  1HPU A;  3H62 B;  2O8A A;  4M0V A;  3H68 A;  2CV9 A;  1II7 A;  1KBP A;  4FBQ A;  4O5G A;  1OIE A;  3E0J A;  4KKZ A;  2QFP A;  4KBP A;  3T1I A;  4V0V A;  5JPE A;  3K7V C;  3AUZ A;  4H1S A;  2ZOA A;  3H61 A;  2USH A;  1Z2W A;  3N5U A;  4H2G A;  1AUI A;  4DT2 A;  1XM7 A;  2A22 A;  3FGA C;  4H1Y P;  4ORB A;  5JPF A;  3H67 A;  1T71 A;  1W24 A;  3C9F A;  1FJM A;  1HP1 A;  2BQ8 X;  2WDD A;  4V0X A;  2ZBM A;  4ORA A;  4V0W A;  2HYO A;  1QHW A;  4FBK A;  4LAC C;  4B2O A;  4H2F A;  3IVE A;  5J28 A;  3QFK A;  1XZW A;  1Z2X A;  4G9J A;  2Z1A A;  2JOG A;  1M63 A;  3QFO A;  3RL3 A;  5F3W A;  4H2I A;  1T70 A;  4TUG A;  1NNW A;  3AV0 A;  2DXN A;  5DNY A;  3P71 C;  3THO B;  1S70 A;  2GJU A;  3EGG A;  3LL8 A;  2IAE C;  3D03 A;  1SU1 A;  1U32 A;  1WAR A;  2P6B A;  4UT3 A;  4J6O A;  1IT6 A;  2R17 A;  4LTY A;  2BCD A;  3PSO A;  3H60 A;  4DSY A;  2DFJ A;  3DSD A;  3H69 A;  2AHD A;  4OR9 A;  3QFM A;  4ZX2 A;  2YEQ A;  3H64 A;  2NPP C;  3DW8 C;  4F0Z A;  4JA9 A;  1OID A;  4FBW A;  3KBP A;  3THN A;  1S8E A;  2NYM C;  2ZO9 B;  4O43 A;  2QJC A;  2XMO A;  4WWL A;  2WDF A;  4UT2 A;  4FCX A;  3HVQ A;  3TGH A;  1UF3 A;  3CK2 A;  1USH A;  4I5N C;  5EQV A;  5B8I A;  3FLO A;  4UWQ A;  1S3L A;  5C1V A;  4UT3 B;  3V4Y A;  3H66 A;  1JK7 A;  3GVE A;  4MP0 A;  1S3M A; 
#chains in the Genus database with same CATH homology
 3QG5 C;  2NYL C;  5JJT A;  4HD0 A;  2QFR A;  3IB8 A;  2YVT A;  1G5B A;  2Q8U A;  2HY1 A;  3C5W C;  2Z06 A;  3JYF A;  1S95 A;  5GTU A;  3ZTV A;  4TUI A;  2KKN A;  3H63 A;  4IYP C;  2IE3 C;  4I5L C;  4DHL A;  2Z72 A;  3ICF A;  2WDC A;  4ORC A;  2WDE A;  4LU9 A;  4YKE A;  1OI8 A;  4IL1 A;  4Q7F A;  4ZVZ A;  3EGH A;  1QFC A;  3PSN A;  1WAO 1;  5IOH A;  5INB A;  2DXL A;  1MF8 A;  4MOV A;  3RL4 A;  4JA7 A;  4MOY A;  3IVD A;  4O4K A;  4NZV A;  3RL5 A;  3DSC A;  1HO5 A;  2BDX A;  4H2B A;  2IE4 C;  3IB7 A;  3ZU0 A;  5HPE A;  1S3N A;  1UTE A;  3E7A A;  1TCO A;  1V73 A;  3RQZ A;  3QFN A;  3E7B A;  4XPN A;  3K7W C;  2HYP A;  4O24 A;  2NXF A;  2O8G A;  1HPU A;  3H62 B;  2O8A A;  4M0V A;  3H68 A;  2CV9 A;  1II7 A;  1KBP A;  4FBQ A;  4O5G A;  1OIE A;  3E0J A;  4KKZ A;  2QFP A;  4KBP A;  3T1I A;  4V0V A;  5JPE A;  3K7V C;  3AUZ A;  4H1S A;  2ZOA A;  3H61 A;  2USH A;  1Z2W A;  3N5U A;  4H2G A;  1AUI A;  4DT2 A;  1XM7 A;  2A22 A;  3FGA C;  4H1Y P;  4ORB A;  5JPF A;  3H67 A;  1T71 A;  1W24 A;  3C9F A;  1FJM A;  1HP1 A;  2BQ8 X;  2WDD A;  4V0X A;  2ZBM A;  4ORA A;  4V0W A;  2HYO A;  1QHW A;  4FBK A;  4LAC C;  4B2O A;  4H2F A;  3IVE A;  5J28 A;  3QFK A;  1XZW A;  1Z2X A;  4G9J A;  2Z1A A;  2JOG A;  1M63 A;  3QFO A;  3RL3 A;  5F3W A;  4H2I A;  1T70 A;  4TUG A;  1NNW A;  3AV0 A;  2DXN A;  5DNY A;  3P71 C;  3THO B;  1S70 A;  2GJU A;  3EGG A;  3LL8 A;  2IAE C;  3D03 A;  1SU1 A;  1U32 A;  1WAR A;  2P6B A;  4UT3 A;  4J6O A;  1IT6 A;  2R17 A;  4LTY A;  2BCD A;  3PSO A;  3H60 A;  4DSY A;  2DFJ A;  3DSD A;  3H69 A;  2AHD A;  4OR9 A;  3QFM A;  4ZX2 A;  2YEQ A;  3H64 A;  2NPP C;  3DW8 C;  4F0Z A;  4JA9 A;  1OID A;  4FBW A;  3KBP A;  3THN A;  1S8E A;  2NYM C;  2ZO9 B;  4O43 A;  2QJC A;  2XMO A;  4WWL A;  2WDF A;  4UT2 A;  4FCX A;  3HVQ A;  3TGH A;  1UF3 A;  3CK2 A;  1USH A;  4I5N C;  5EQV A;  5B8I A;  3FLO A;  4UWQ A;  1S3L A;  5C1V A;  4UT3 B;  3V4Y A;  3H66 A;  1JK7 A;  3GVE A;  4MP0 A;  1S3M A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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