5GTUA

Structural and mechanistic insights into regulation of the retromer coat by tbc1d5
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
186
structure length
186
Chain Sequence
MAGHRLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and mechanistic insights into regulation of the retromer coat by TBC1d5
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords Vacuolar protein sorting-associated protein 29
total genus 49
structure length 186
sequence length 186
ec nomenclature
pdb deposition date 2016-08-23
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.21.10 Alpha Beta 4-Layer Sandwich Purple Acid Phosphatase; chain A, domain 2 Purple Acid Phosphatase; chain A, domain 2 5gtuA00
4DSYA 2HY1A 2WDDA 2Z1AA 2ZBMA 2BCDA 3H67A 3ICFA 4OR9A 3H63A 3QFOA 5JPEA 2NYLC 2Z06A 4H2IA 2IE3C 2JOGA 4H2BA 2NYMC 2Z72A 1XZWA 4I5LC 4MOYA 1S8EA 2AHDA 2QFPA 4IYPC 4JA7A 1OI8A 1S70A 3QFKA 3RL4A 4TUIA 2CV9A 3FGAC 4ZX2A 4M0VA 4FCXA 1WARA 4FBWA 1II7A 1M63A 4H1SA 4O4KA 4V0VA 4YKEA 2BDXA 1TCOA 3PSOA 4G9JA 3KBPA 3E7AA 4B2OA 1S3MA 5JJTA 5B8IA 2Q8UA 1JK7A 1OIEA 3ZTVA 3C5WC 3EGHA 3RL3A 4LACC 2WDCA 1T70A 4ZVZA 2KKNA 4TUGA 1USHA 4LU9A 3THOB 4FBQA 3DSDA 1IT6A 2P6BA 2HYPA 2DFJA 3AV0A 4I5NC 3H64A 5J28A 1HO5A 3IVDA 4H2GA 4ORAA 4MOVA 1FJMA 1HPUA 2IE4C 2NXFA 3K7WC 4V0WA 1T71A 4WWLA 4ORCA 4IL1A 3IVEA 1MF8A 5GTUA 4KKZA 3C9FA 4FBKA 3E7BA 3HVQA 4O43A 4DT2A 1V73A 2YVTA 3H69A 2IAEC 3N5UA 3PSNA 1HP1A 2WDFA 3RL5A 3ZU0A 3H68A 1U32A 2WDEA 4XPNA 2QFRA 3AUZA 2O8GA 3JYFA 3QFNA 3K7VC 4NZVA 4UT2A 5C1VA 5DNYA 4O24A 2QJCA 3EGGA 3P71C 5HPEA 4H1YP 3H62B 2NPPC 3DW8C 1S3LA 4J6OA 1NNWA 3H61A 3H60A 1Z2WA 4Q7FA 3V4YA 1SU1A 3QFMA 4KBPA 5IOHA 3RQZA 5EQVA 3THNA 5JPFA 1OIDA 3IB8A 2R17A 1UTEA 2GJUA 1AUIA 4DHLA 2HYOA 4F0ZA 1G5BA 4V0XA 2XMOA 1WAO1 3QG5C 1W24A 2USHA 3T1IA 4O5GA 4UT3A 3IB7A 1UF3A 3CK2A 3TGHA 3DSCA 4HD0A 5F3WA 4MP0A 3LL8A 5INBA 1Z2XA 4UWQA 1QHWA 1QFCA 1S95A 2A22A 3GVEA 4LTYA 4UT3B 4ORBA 3H66A 2O8AA 4H2FA 1S3NA 1KBPA 2BQ8X 1XM7A 4JA9A
chains in the Genus database with same CATH superfamily
4DSYA 2HY1A 2WDDA 2Z1AA 2ZBMA 2BCDA 3H67A 3ICFA 4OR9A 3H63A 3QFOA 5JPEA 2NYLC 2Z06A 4H2IA 2IE3C 2JOGA 4H2BA 2NYMC 2Z72A 1XZWA 4I5LC 4MOYA 1S8EA 2AHDA 2QFPA 4IYPC 4JA7A 1OI8A 1S70A 3QFKA 3RL4A 4TUIA 2DXLA 3D03A 2CV9A 3FGAC 4ZX2A 4M0VA 4FCXA 1WARA 4FBWA 1II7A 1M63A 4H1SA 4O4KA 4V0VA 4YKEA 2BDXA 1TCOA 3PSOA 4G9JA 3KBPA 3E7AA 4B2OA 1S3MA 5JJTA 5B8IA 2Q8UA 1JK7A 2ZOAA 1OIEA 3ZTVA 3C5WC 3EGHA 3RL3A 4LACC 2WDCA 1T70A 4ZVZA 2KKNA 4TUGA 1USHA 4LU9A 3THOB 4FBQA 3DSDA 1IT6A 2P6BA 2HYPA 2DFJA 3AV0A 4I5NC 3H64A 5J28A 1HO5A 3IVDA 4H2GA 4ORAA 4MOVA 1FJMA 1HPUA 2IE4C 2NXFA 3K7WC 4V0WA 1T71A 4WWLA 4ORCA 4IL1A 3IVEA 1MF8A 5GTUA 4KKZA 2YEQA 3C9FA 4FBKA 3E7BA 3HVQA 4O43A 4DT2A 1V73A 2YVTA 3H69A 2IAEC 3N5UA 3PSNA 1HP1A 2WDFA 3RL5A 3ZU0A 3H68A 2ZO9B 1U32A 2WDEA 4XPNA 2QFRA 3AUZA 2O8GA 2DXNA 3JYFA 3QFNA 3K7VC 4NZVA 4UT2A 5C1VA 5DNYA 4O24A 2QJCA 3EGGA 3P71C 5HPEA 4H1YP 3H62B 2NPPC 3DW8C 1S3LA 4J6OA 1NNWA 3H61A 3H60A 1Z2WA 4Q7FA 3V4YA 1SU1A 3QFMA 4KBPA 5IOHA 3RQZA 5EQVA 3THNA 5JPFA 1OIDA 3IB8A 2R17A 1UTEA 2GJUA 1AUIA 4DHLA 2HYOA 3E0JA 1G5BA 4V0XA 4F0ZA 2XMOA 1WAO1 3QG5C 1W24A 2USHA 3T1IA 4O5GA 4UT3A 3IB7A 1UF3A 3CK2A 3TGHA 3DSCA 4HD0A 5F3WA 4MP0A 3LL8A 5INBA 1Z2XA 4UWQA 1QHWA 1QFCA 1S95A 2A22A 3GVEA 4LTYA 4UT3B 4ORBA 3H66A 3FLOA 2O8AA 4H2FA 1S3NA 1KBPA 2BQ8X 1XM7A 4JA9A
chains in the Genus database with same CATH topology
4DSYA 2HY1A 2WDDA 2Z1AA 2ZBMA 2BCDA 3H67A 3ICFA 4OR9A 3H63A 3QFOA 5JPEA 2NYLC 2Z06A 4H2IA 2IE3C 2JOGA 4H2BA 2NYMC 2Z72A 1XZWA 4I5LC 4MOYA 1S8EA 2AHDA 2QFPA 4IYPC 4JA7A 1OI8A 1S70A 3QFKA 3RL4A 4TUIA 2DXLA 3D03A 2CV9A 3FGAC 4ZX2A 4M0VA 4FCXA 1WARA 4FBWA 1II7A 1M63A 4H1SA 4O4KA 4V0VA 4YKEA 2BDXA 1TCOA 3PSOA 4G9JA 3KBPA 3E7AA 4B2OA 1S3MA 5JJTA 5B8IA 2Q8UA 1JK7A 2ZOAA 1OIEA 3ZTVA 3C5WC 3EGHA 3RL3A 4LACC 2WDCA 1T70A 4ZVZA 2KKNA 4TUGA 1USHA 4LU9A 3THOB 4FBQA 3DSDA 1IT6A 2P6BA 2HYPA 2DFJA 3AV0A 4I5NC 3H64A 5J28A 1HO5A 3IVDA 4H2GA 4ORAA 4MOVA 1FJMA 1HPUA 2IE4C 2NXFA 3K7WC 4V0WA 1T71A 4WWLA 4ORCA 4IL1A 3IVEA 1MF8A 5GTUA 4KKZA 2YEQA 3C9FA 4FBKA 3E7BA 3HVQA 4O43A 4DT2A 1V73A 2YVTA 3H69A 2IAEC 3N5UA 3PSNA 1HP1A 2WDFA 3RL5A 3ZU0A 3H68A 2ZO9B 1U32A 2WDEA 4XPNA 2QFRA 3AUZA 2O8GA 2DXNA 3JYFA 3QFNA 3K7VC 4NZVA 4UT2A 5C1VA 5DNYA 4O24A 2QJCA 3EGGA 3P71C 5HPEA 4H1YP 3H62B 2NPPC 3DW8C 1S3LA 4J6OA 1NNWA 3H61A 3H60A 1Z2WA 4Q7FA 3V4YA 1SU1A 3QFMA 4KBPA 5IOHA 3RQZA 5EQVA 3THNA 5JPFA 1OIDA 3IB8A 2R17A 1UTEA 2GJUA 1AUIA 4DHLA 2HYOA 3E0JA 1G5BA 4V0XA 4F0ZA 2XMOA 1WAO1 3QG5C 1W24A 2USHA 3T1IA 4O5GA 4UT3A 3IB7A 1UF3A 3CK2A 3TGHA 3DSCA 4HD0A 5F3WA 4MP0A 3LL8A 5INBA 1Z2XA 4UWQA 1QHWA 1QFCA 1S95A 2A22A 3GVEA 4LTYA 4UT3B 4ORBA 3H66A 3FLOA 2O8AA 4H2FA 1S3NA 1KBPA 2BQ8X 1XM7A 4JA9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DSY A;  2HY1 A;  2WDD A;  2Z1A A;  2ZBM A;  2BCD A;  3H67 A;  3ICF A;  4OR9 A;  3H63 A;  3QFO A;  5JPE A;  2NYL C;  2Z06 A;  4H2I A;  2IE3 C;  2JOG A;  4H2B A;  2NYM C;  2Z72 A;  1XZW A;  4I5L C;  4MOY A;  1S8E A;  2AHD A;  2QFP A;  4IYP C;  4JA7 A;  1OI8 A;  1S70 A;  3QFK A;  3RL4 A;  4TUI A;  2CV9 A;  3FGA C;  4ZX2 A;  4M0V A;  4FCX A;  1WAR A;  4FBW A;  1II7 A;  1M63 A;  4H1S A;  4O4K A;  4V0V A;  4YKE A;  2BDX A;  1TCO A;  3PSO A;  4G9J A;  3KBP A;  3E7A A;  4B2O A;  1S3M A;  5JJT A;  5B8I A;  2Q8U A;  1JK7 A;  1OIE A;  3ZTV A;  3C5W C;  3EGH A;  3RL3 A;  4LAC C;  2WDC A;  1T70 A;  4ZVZ A;  2KKN A;  4TUG A;  1USH A;  4LU9 A;  3THO B;  4FBQ A;  3DSD A;  1IT6 A;  2P6B A;  2HYP A;  2DFJ A;  3AV0 A;  4I5N C;  3H64 A;  5J28 A;  1HO5 A;  3IVD A;  4H2G A;  4ORA A;  4MOV A;  1FJM A;  1HPU A;  2IE4 C;  2NXF A;  3K7W C;  4V0W A;  1T71 A;  4WWL A;  4ORC A;  4IL1 A;  3IVE A;  1MF8 A;  5GTU A;  4KKZ A;  3C9F A;  4FBK A;  3E7B A;  3HVQ A;  4O43 A;  4DT2 A;  1V73 A;  2YVT A;  3H69 A;  2IAE C;  3N5U A;  3PSN A;  1HP1 A;  2WDF A;  3RL5 A;  3ZU0 A;  3H68 A;  1U32 A;  2WDE A;  4XPN A;  2QFR A;  3AUZ A;  2O8G A;  3JYF A;  3QFN A;  3K7V C;  4NZV A;  4UT2 A;  5C1V A;  5DNY A;  4O24 A;  2QJC A;  3EGG A;  3P71 C;  5HPE A;  4H1Y P;  3H62 B;  2NPP C;  3DW8 C;  1S3L A;  4J6O A;  1NNW A;  3H61 A;  3H60 A;  1Z2W A;  4Q7F A;  3V4Y A;  1SU1 A;  3QFM A;  4KBP A;  5IOH A;  3RQZ A;  5EQV A;  3THN A;  5JPF A;  1OID A;  3IB8 A;  2R17 A;  1UTE A;  2GJU A;  1AUI A;  4DHL A;  2HYO A;  4F0Z A;  1G5B A;  4V0X A;  2XMO A;  1WAO 1;  3QG5 C;  1W24 A;  2USH A;  3T1I A;  4O5G A;  4UT3 A;  3IB7 A;  1UF3 A;  3CK2 A;  3TGH A;  3DSC A;  4HD0 A;  5F3W A;  4MP0 A;  3LL8 A;  5INB A;  1Z2X A;  4UWQ A;  1QHW A;  1QFC A;  1S95 A;  2A22 A;  3GVE A;  4LTY A;  4UT3 B;  4ORB A;  3H66 A;  2O8A A;  4H2F A;  1S3N A;  1KBP A;  2BQ8 X;  1XM7 A;  4JA9 A; 
#chains in the Genus database with same CATH topology
 4DSY A;  2HY1 A;  2WDD A;  2Z1A A;  2ZBM A;  2BCD A;  3H67 A;  3ICF A;  4OR9 A;  3H63 A;  3QFO A;  5JPE A;  2NYL C;  2Z06 A;  4H2I A;  2IE3 C;  2JOG A;  4H2B A;  2NYM C;  2Z72 A;  1XZW A;  4I5L C;  4MOY A;  1S8E A;  2AHD A;  2QFP A;  4IYP C;  4JA7 A;  1OI8 A;  1S70 A;  3QFK A;  3RL4 A;  4TUI A;  2DXL A;  3D03 A;  2CV9 A;  3FGA C;  4ZX2 A;  4M0V A;  4FCX A;  1WAR A;  4FBW A;  1II7 A;  1M63 A;  4H1S A;  4O4K A;  4V0V A;  4YKE A;  2BDX A;  1TCO A;  3PSO A;  4G9J A;  3KBP A;  3E7A A;  4B2O A;  1S3M A;  5JJT A;  5B8I A;  2Q8U A;  1JK7 A;  2ZOA A;  1OIE A;  3ZTV A;  3C5W C;  3EGH A;  3RL3 A;  4LAC C;  2WDC A;  1T70 A;  4ZVZ A;  2KKN A;  4TUG A;  1USH A;  4LU9 A;  3THO B;  4FBQ A;  3DSD A;  1IT6 A;  2P6B A;  2HYP A;  2DFJ A;  3AV0 A;  4I5N C;  3H64 A;  5J28 A;  1HO5 A;  3IVD A;  4H2G A;  4ORA A;  4MOV A;  1FJM A;  1HPU A;  2IE4 C;  2NXF A;  3K7W C;  4V0W A;  1T71 A;  4WWL A;  4ORC A;  4IL1 A;  3IVE A;  1MF8 A;  5GTU A;  4KKZ A;  2YEQ A;  3C9F A;  4FBK A;  3E7B A;  3HVQ A;  4O43 A;  4DT2 A;  1V73 A;  2YVT A;  3H69 A;  2IAE C;  3N5U A;  3PSN A;  1HP1 A;  2WDF A;  3RL5 A;  3ZU0 A;  3H68 A;  2ZO9 B;  1U32 A;  2WDE A;  4XPN A;  2QFR A;  3AUZ A;  2O8G A;  2DXN A;  3JYF A;  3QFN A;  3K7V C;  4NZV A;  4UT2 A;  5C1V A;  5DNY A;  4O24 A;  2QJC A;  3EGG A;  3P71 C;  5HPE A;  4H1Y P;  3H62 B;  2NPP C;  3DW8 C;  1S3L A;  4J6O A;  1NNW A;  3H61 A;  3H60 A;  1Z2W A;  4Q7F A;  3V4Y A;  1SU1 A;  3QFM A;  4KBP A;  5IOH A;  3RQZ A;  5EQV A;  3THN A;  5JPF A;  1OID A;  3IB8 A;  2R17 A;  1UTE A;  2GJU A;  1AUI A;  4DHL A;  2HYO A;  3E0J A;  1G5B A;  4V0X A;  4F0Z A;  2XMO A;  1WAO 1;  3QG5 C;  1W24 A;  2USH A;  3T1I A;  4O5G A;  4UT3 A;  3IB7 A;  1UF3 A;  3CK2 A;  3TGH A;  3DSC A;  4HD0 A;  5F3W A;  4MP0 A;  3LL8 A;  5INB A;  1Z2X A;  4UWQ A;  1QHW A;  1QFC A;  1S95 A;  2A22 A;  3GVE A;  4LTY A;  4UT3 B;  4ORB A;  3H66 A;  3FLO A;  2O8A A;  4H2F A;  1S3N A;  1KBP A;  2BQ8 X;  1XM7 A;  4JA9 A; 
#chains in the Genus database with same CATH homology
 4DSY A;  2HY1 A;  2WDD A;  2Z1A A;  2ZBM A;  2BCD A;  3H67 A;  3ICF A;  4OR9 A;  3H63 A;  3QFO A;  5JPE A;  2NYL C;  2Z06 A;  4H2I A;  2IE3 C;  2JOG A;  4H2B A;  2NYM C;  2Z72 A;  1XZW A;  4I5L C;  4MOY A;  1S8E A;  2AHD A;  2QFP A;  4IYP C;  4JA7 A;  1OI8 A;  1S70 A;  3QFK A;  3RL4 A;  4TUI A;  2DXL A;  3D03 A;  2CV9 A;  3FGA C;  4ZX2 A;  4M0V A;  4FCX A;  1WAR A;  4FBW A;  1II7 A;  1M63 A;  4H1S A;  4O4K A;  4V0V A;  4YKE A;  2BDX A;  1TCO A;  3PSO A;  4G9J A;  3KBP A;  3E7A A;  4B2O A;  1S3M A;  5JJT A;  5B8I A;  2Q8U A;  1JK7 A;  2ZOA A;  1OIE A;  3ZTV A;  3C5W C;  3EGH A;  3RL3 A;  4LAC C;  2WDC A;  1T70 A;  4ZVZ A;  2KKN A;  4TUG A;  1USH A;  4LU9 A;  3THO B;  4FBQ A;  3DSD A;  1IT6 A;  2P6B A;  2HYP A;  2DFJ A;  3AV0 A;  4I5N C;  3H64 A;  5J28 A;  1HO5 A;  3IVD A;  4H2G A;  4ORA A;  4MOV A;  1FJM A;  1HPU A;  2IE4 C;  2NXF A;  3K7W C;  4V0W A;  1T71 A;  4WWL A;  4ORC A;  4IL1 A;  3IVE A;  1MF8 A;  5GTU A;  4KKZ A;  2YEQ A;  3C9F A;  4FBK A;  3E7B A;  3HVQ A;  4O43 A;  4DT2 A;  1V73 A;  2YVT A;  3H69 A;  2IAE C;  3N5U A;  3PSN A;  1HP1 A;  2WDF A;  3RL5 A;  3ZU0 A;  3H68 A;  2ZO9 B;  1U32 A;  2WDE A;  4XPN A;  2QFR A;  3AUZ A;  2O8G A;  2DXN A;  3JYF A;  3QFN A;  3K7V C;  4NZV A;  4UT2 A;  5C1V A;  5DNY A;  4O24 A;  2QJC A;  3EGG A;  3P71 C;  5HPE A;  4H1Y P;  3H62 B;  2NPP C;  3DW8 C;  1S3L A;  4J6O A;  1NNW A;  3H61 A;  3H60 A;  1Z2W A;  4Q7F A;  3V4Y A;  1SU1 A;  3QFM A;  4KBP A;  5IOH A;  3RQZ A;  5EQV A;  3THN A;  5JPF A;  1OID A;  3IB8 A;  2R17 A;  1UTE A;  2GJU A;  1AUI A;  4DHL A;  2HYO A;  3E0J A;  1G5B A;  4V0X A;  4F0Z A;  2XMO A;  1WAO 1;  3QG5 C;  1W24 A;  2USH A;  3T1I A;  4O5G A;  4UT3 A;  3IB7 A;  1UF3 A;  3CK2 A;  3TGH A;  3DSC A;  4HD0 A;  5F3W A;  4MP0 A;  3LL8 A;  5INB A;  1Z2X A;  4UWQ A;  1QHW A;  1QFC A;  1S95 A;  2A22 A;  3GVE A;  4LTY A;  4UT3 B;  4ORB A;  3H66 A;  3FLO A;  2O8A A;  4H2F A;  1S3N A;  1KBP A;  2BQ8 X;  1XM7 A;  4JA9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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